Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGAE Gene

protein-coding   GIFtS: 60
GCID: GC17M003617

Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1;
Alpha Polypeptide)1 2
     HUMINAE2
Integrin Alpha-IEL2 3     Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide2
Mucosal Lymphocyte 1 Antigen2 3     Integrin Alpha-E2
HML-1 Antigen2 3     CD103 Antigen3
CD1032     

External Ids:    HGNC: 61471   Entrez Gene: 36822   Ensembl: ENSG000000834577   OMIM: 6046825   UniProtKB: P385703   

Export aliases for ITGAE gene to outside databases

Previous GC identifers: GC17M003930 GC17M003960 GC17M003568 GC17M003824 GC17M003564 GC17M003513


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAE Gene:
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene
encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular
domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein
forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is
preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in
adhesion, it may serve as an accessory molecule for IEL activation. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGAE Gene: 
ITGAE (integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)) is a protein-coding gene. Diseases associated with ITGAE include nephropathic cystinosis, and cystinosis, and among its related super-pathways are Integrin-mediated cell adhesion and FAK1 Signaling. GO annotations related to this gene include metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial
T-lymphocytes to epithelial cell monolayers

Gene Wiki entry for ITGAE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGAE gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   AML1a   Nkx3-1 v1   Nkx3-1 v2   MZF-1   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGAE promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGAE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

ITGAE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAE gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003617:  view genomic region     (about GC identifiers)

Start:
3,617,919 bp from pter      End:
3,704,537 bp from pter
Size:
86,619 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570 (See protein sequence)
Recommended Name: Integrin alpha-E precursor  
Size: 1179 amino acids; 130159 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains
linked by a disulfide bond. Alpha-E associates with beta-7
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q17RS6 Q9NZU9

Explore the universe of human proteins at neXtProt for ITGAE: NX_P38570

Explore proteomics data for ITGAE at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P38570

  • ITGAE Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGAE Protein Expression
    REFSEQ proteins: NP_002199.3  
    ENSEMBL proteins: 
     ENSP00000263087   ENSP00000467977  
    Reactome Protein details: P38570
    Human Recombinant Protein Products for ITGAE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGAE
    OriGene Protein Over-expression Lysate for ITGAE
    OriGene MassSpec for ITGAE 
    OriGene Custom Protein Services for ITGAE
    GenScript Custom Purified and Recombinant Proteins Services for ITGAE
    Novus Biologicals ITGAE Protein
    Novus Biologicals ITGAE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--

    ITGAE for ontologies           About GeneDecksing



    ITGAE Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAE
    R&D Systems Antibodies for ITGAE (Integrin alpha E/CD103)
    OriGene Antibodies for ITGAE
    OriGene Custom Antibody Services for ITGAE
    GenScript Custom Superior Antibodies Services for ITGAE
    Novus Biologicals ITGAE Antibodies
    Abcam antibodies for ITGAE
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ITGAE
    LSBio Antibodies in human, mouse, rat for ITGAE 

    Assay Products for ITGAE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAE
    R&D Systems Proteome Profiler Antibody Arrays for ITGAE (Integrin alpha E/CD103)
    GenScript Custom Assay Services for ITGAE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P38570

    ProtoNet protein and cluster: P38570

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGAE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAE_HUMAN, P38570
    Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial
    T-lymphocytes to epithelial cell monolayers
    Induction: Integrin alpha-E/beta-7 is induced by TGFB1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ITGAE for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itgae):
     hematopoietic system  immune system 

    ITGAE for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itgaetm1Cmp for ITGAE

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGAE 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGAE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAE 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAE 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGAE
    SwitchGear 3'UTR luciferase reporter plasmidITGAE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAE
    Sirion Biotech Customized adenovirus for overexpression of ITGAE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGAE (see all 8)
    OriGene ORF clones in mouse, rat for ITGAE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAE (NM_002208)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE
    Sirion Biotech Customized lentivirus for stable overexpression of ITGAE 
                         Customized lentivirus expression plasmids for stable overexpression of ITGAE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAE
    Search LifeMap BioReagents cell lines for ITGAE
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGAE About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    RhoA Pathway0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAE (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGAE
        Focal Adhesion
    Integrin-mediated cell adhesion
    E-cadherin signaling in the nascent adherens junction

    2        Reactome Pathways for ITGAE
        Integrin cell surface interactions
    Signal Transduction


    1         Kegg Pathway  (Kegg details for ITGAE):
        Regulation of actin cytoskeleton


    ITGAE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITGAE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for ITGAE (P385702, 3 ENSP000002630874) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHFRQ96EP12, 3, ENSP000003205574MINT-65140 I2D: score=4 STRING: ENSP00000320557
    EEDO755303, ENSP000002633604I2D: score=5 STRING: ENSP00000263360
    ITGB7P260103, ENSP000002670824I2D: score=3 STRING: ENSP00000267082
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    ITGAE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGAE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGAE (ITAE)

    1 Novoseek inferred chemical compound relationship for ITGAE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha e 86.9 4 11867163 (2), 10737767 (1), 15093560 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGAE / ITAE

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGAE gene: 
    NM_002208.4  

    Unigene Cluster for ITGAE:

    Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
    Hs.513867  [show with all ESTs]
    Unigene Representative Sequence: L25851
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572179(uc002fwn.4) ENST00000263087(uc002fwo.4) ENST00000572433
    ENST00000571937 ENST00000570415 ENST00000570360 ENST00000571185 ENST00000574026
    ENST00000572121
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGAE
    SwitchGear 3'UTR luciferase reporter plasmidITGAE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAE
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAE (see all 8)
    OriGene ORF clones in mouse, rat for ITGAE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAE (NM_002208)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE
    Sirion Biotech Customized lentivirus for stable overexpression of ITGAE 
                         Customized lentivirus expression plasmids for stable overexpression of ITGAE 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAE

    Additional mRNA sequence: 

    AF289864.1 AK097567.1 BC113436.1 BC117207.1 L25851.2 

    12 DOTS entries:

    DT.441861  DT.92426789  DT.75107961  DT.97768637  DT.87002140  DT.95368901  DT.120992626  DT.92426792 
    DT.95198501  DT.95368899  DT.97823164  DT.402551 

    24/158 AceView cDNA sequences (see all 158):

    BF056043 BM825485 AW027978 AK097567 BG758439 AW002498 BE504062 BE218259 
    CA309601 AI652636 AI278238 CD678015 BE550470 AI824883 AI817823 AA503512 
    CA438028 CD369106 CF130501 AI205492 AA569942 BF449000 AI132981 W74608 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGAE expression in normal human tissues (normalized intensities)      ITGAE embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGTTGG
    ITGAE Expression
    About this image


    ITGAE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen

    See ITGAE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGAE

    SOURCE GeneReport for Unigene cluster: Hs.513867

    UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
    Tissue specificity: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are
    located between mucosal epithelial cells

        SABiosciences Custom PCR Arrays for ITGAE
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAE
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAE
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGAE gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgae1 , 5 integrin alpha E, epithelial-associated1, 5 78.9(n)1
    70.71(a)1
      11 (45.22 cM)5
    164071  NM_008399.21  NP_032425.21 
     730905835 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367051 integrin alpha-E-like 48.75(n)
    38.06(a)
      100536705  XM_003200028.1  XP_003200076.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaPS46
    scb6
    (see all 3)
    scab
    (see all 3)
    17(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(11146272-11150371)
    2R(11136290-11146003)


    ENSEMBL Gene Tree for ITGAE (if available)
    TreeFam Gene Tree for ITGAE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGAE gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  

    ITGAE for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ITGAE
    PGOHUM00000243168


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2279 SNPs in ITGAE are shown (see all 2279)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0088854
    ----see VAR_0088852 C S mis40--------
    VAR_0088844
    ----see VAR_0088842 D E mis40--------
    rs711533901,2
    C--3514757(+) TTTCC-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs668349601,2
    C--3534552(+) TTGTA-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs65027411,2
    C,A--3617456(+) gacctC/Tgtgat 1 -- ds50010--------
    rs1849425481,2
    --3617543(+) TTTGAA/GATGGA 1 -- ds50010--------
    rs1901467471,2
    --3617591(+) ATCTCA/GGCTCA 1 -- ds50010--------
    rs80686181,2
    C,F,A--3617667(+) caggcG/Acccgc 1 -- ds50013Minor allele frequency- A:0.50NA 6
    rs80670471,2
    C--3617727(+) atgttA/Ggctag 1 -- ds50010--------
    rs129386231,2
    C,F--3617730(+) TTGGCT/CAGGAT 1 -- ds50015Minor allele frequency- C:0.40NA 10

    HapMap Linkage Disequilibrium report for ITGAE (3617919 - 3704537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ITGAE:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv996976CNV Deletion20482838
    esv1749908CNV Insertion17803354
    esv1004185CNV Insertion20482838
    nsv1949CNV Insertion18451855
    nsv833342CNV Loss17160897
    nsv907571CNV Loss21882294
    esv24017CNV Loss19812545
    nsv1948CNV Loss18451855
    nsv907570CNV Gain21882294
    nsv469791CNV Complex16826518


    Human Gene Mutation Database (HGMD): ITGAE
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAE
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604682    OMIM disorders: --

    20/31 diseases for ITGAE (see all 31):    About MalaCards
    nephropathic cystinosis    cystinosis    splenic marginal zone lymphoma    mycosis fungoides
    hairy cell leukemia    pulmonary sarcoidosis    macroglobulinemia    dengue hemorrhagic fever
    cutaneous t cell lymphoma    sarcoidosis    t-cell leukemia    adult t-cell leukemia
    hemorrhagic fever    tonsillitis    chronic myeloid leukemia    inflammatory bowel disease
    celiac disease    esophageal cancer    pancreatic cancer    b-cell lymphomas

    4 diseases from the University of Copenhagen DISEASES database for ITGAE:
    Hairy cell leukemia     Lymphoma     Kawasaki disease     Celiac disease

    ITGAE for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for ITGAE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell cutaneous 40.1 1 8864917 (1)
    mycosis fungoides 38.6 1 7977645 (1)
    inflammatory bowel diseases 29.3 2 14532999 (2)
    lymphoma 25.2 2 7977645 (1), 8780585 (1)
    lymphoma t-cell 24.9 1 8780585 (1)
    pancreatic cancer 11.3 2 12434297 (2)
    necrosis 1.57 1 12434297 (1)
    tumors 0.97 2 8780585 (1), 19638592 (1)
    leukemia 0 1 1697100 (1)
    renal disease 0 1 12717221 (1)

    Genetic Association Database (GAD): ITGAE
    Human Genome Epidemiology (HuGE) Navigator: ITGAE (8 documents)

    Export disorders for ITGAE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGAE gene, integrated from 9 sources (see all 95):
    (articles sorted by number of sources associating them with ITGAE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. (PubMed id 8119947)1, 2, 3, 9 Shaw S.K....Parker C.M. (1994)
    2. A family of beta 7 integrins on human mucosal lymphocytes. (PubMed id 1542691)1, 2, 9 Parker C.M.... Brenner M.B. (1992)
    3. Disease association of the CD103 polymorphisms in Tai wan Chinese Graves' ophthalmopathy patients. (PubMed id 20417566)1, 4 Liu Y.H....Tsai F.J. (2010)
    4. Dengue hemorrhagic fever is associated with polymorph isms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. (2009)
    7. Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography. (PubMed id 19604725)1, 4 Heron M....Van den Bosch J.M. (2009)
    8. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    9. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (2008)
    10. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3682 HGNC: 6147 AceView: ITGAE Ensembl:ENSG00000083457 euGenes: HUgn3682
    ECgene: ITGAE Kegg: 3682 H-InvDB: ITGAE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGAE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGAE gene:
    Search GeneIP for patents involving ITGAE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAE
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ITGAE (Integrin alpha E/CD103)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ITGAE (Integrin alpha E/CD103)  
     OriGene Antibodies for ITGAE   OriGene RNAi products in human, mouse, rat for ITGAE  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGAE  
     OriGene MassSpec something-or-other for ITGAE   OriGene clones in human, mouse for ITGAE  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGAE   OriGene Purified Protein for ITGAE  
     OriGene ORF clones in mouse, rat for ITGAE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGAE   OriGene Custom Protein Services for ITGAE  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGAE
     QIAGEN SeqTarget long-range PCR primers for resequencing ITGAE
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAE
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAE
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAE
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
     GenScript Custom Purified and Recombinant Proteins Services for ITGAE GenScript cDNA clones with any tag delivered in your preferred vector for ITGAE
     GenScript Custom Assay Services for ITGAE GenScript Custom Superior Antibodies Services for ITGAE
     GenScript Custom overexpressing Cell Line Services for ITGAE CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ITGAE promoter
     Search Chromatin IP Primers for ITGAE
     RT2 qPCR Primer Assay in human, mouse, rat ITGAE
     Search GNC Networks for ITGAE
     SABiosciences PCR Arrays including human, mouse, rat ITGAE
     Search Tocris compounds for ITGAE (ITAE)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITGAE antibodies
     ITGAE proteins
     ITGAE lysates
     Antibodies for ITGAE
     See all of Abcam's Antibodies, Kits and Proteins for ITGAE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ITGAE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE
     SwitchGear 3'UTR luciferase reporter plasmids for ITGAE
     SwitchGear Promoter luciferase reporter plasmids for ITGAE
     ThermoFisher Antibodies for ITGAE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGAE
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGAE
    Customized:
     lentivirus for stable overexpression of ITGAE
     lentivirus expression plasmids for stable overexpression of ITGAE
     adenovirus for overexpression of ITGAE
     LSBio Antibodies in human, mouse, rat for ITGAE
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGAE gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4