Aliases for ITGAE Gene
External Ids for ITGAE Gene
Previous GeneCards Identifiers for ITGAE Gene
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGAE Gene
ITGAE (Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide)) is a Protein Coding gene. Diseases associated with ITGAE include splenic marginal zone lymphoma and enteropathy-associated t-cell lymphoma. Among its related pathways are Regulation of actin cytoskeleton and TGF-Beta Pathway. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGAE Gene
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers