Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ITGAE Gene

protein-coding   GIFtS: 61
GCID: GC17M003617

Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte...

  See ITGAE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1;
Alpha Polypeptide)1 2
     HUMINAE2
Integrin Alpha-IEL2 3     Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide2
Mucosal Lymphocyte 1 Antigen2 3     Integrin Alpha-E2
HML-1 Antigen2 3     CD103 Antigen3
CD1032     

External Ids:    HGNC: 61471   Entrez Gene: 36822   Ensembl: ENSG000000834577   OMIM: 6046825   UniProtKB: P385703   

Export aliases for ITGAE gene to outside databases

Previous GC identifers: GC17M003930 GC17M003960 GC17M003568 GC17M003824 GC17M003564 GC17M003513


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ITGAE Gene:
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene
encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular
domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein
forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is
preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in
adhesion, it may serve as an accessory molecule for IEL activation. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGAE Gene:
ITGAE (integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)) is a protein-coding gene. Diseases associated with ITGAE include nephropathic cystinosis, and cystinosis. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial
T-lymphocytes to epithelial cell monolayers

Gene Wiki entry for ITGAE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGAE gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   AML1a   Nkx3-1 v1   Nkx3-1 v2   MZF-1   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGAE promoter sequence
   Search Chromatin IP Primers for ITGAE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGAE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

ITGAE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAE gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003617:  view genomic region     (about GC identifiers)

Start:
3,617,919 bp from pter      End:
3,704,537 bp from pter
Size:
86,619 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570 (See protein sequence)
Recommended Name: Integrin alpha-E precursor  
Size: 1179 amino acids; 130159 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains
linked by a disulfide bond. Alpha-E associates with beta-7
Secondary accessions: Q17RS6 Q9NZU9

Explore the universe of human proteins at neXtProt for ITGAE: NX_P38570

Explore proteomics data for ITGAE at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn49, Asn271, Asn321, Asn444, Asn726, Asn782, Asn857, Asn934, Asn954, Asn1065,
                                 Asn1096
  • Modification sites at PhosphoSitePlus

  • See ITGAE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002199.3  
    ENSEMBL proteins: 
     ENSP00000263087   ENSP00000467977  
    Reactome Protein details: P38570

    ITGAE Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGAE
    OriGene Protein Over-expression Lysate for ITGAE
    OriGene MassSpec for ITGAE
    OriGene Custom Protein Services for ITGAE
    GenScript Custom Purified and Recombinant Proteins Services for ITGAE
    Novus Biologicals ITGAE Protein
    Novus Biologicals ITGAE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGAE 

     
    antibodies-online proteins for ITGAE (3 products) 

     
    antibodies-online peptides for ITGAE

    ITGAE Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAE
    R&D Systems Antibodies for ITGAE (Integrin alpha E/CD103)
    OriGene Antibodies for ITGAE
    OriGene Custom Antibody Services for ITGAE
    Novus Biologicals ITGAE Antibodies
    Abcam antibodies for ITGAE
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ITGAE
    antibodies-online antibodies for ITGAE (189 products) 

    ITGAE Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAE
    R&D Systems Proteome Profiler Antibody Arrays for ITGAE (Integrin alpha E/CD103)
    GenScript Custom Assay Services for ITGAE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGAE 
    antibodies-online kits for ITGAE (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P38570

    ProtoNet protein and cluster: P38570

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGAE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAE_HUMAN, P38570
    Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial
    T-lymphocytes to epithelial cell monolayers
    Induction: Integrin alpha-E/beta-7 is induced by TGFB1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGAE           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itgae):
     hematopoietic system  immune system 

    Find genes that share phenotypes with ITGAE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itgaetm1Cmp for ITGAE

       genOway: Develop your customized and physiologically relevant rodent model for ITGAE

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ITGAE using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITGAE
    SwitchGear 3'UTR luciferase reporter plasmidITGAE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGAE
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAE

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAE

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAE (see all 7)
    OriGene ORF clones in mouse, rat for ITGAE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAE (NM_002208)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAE
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGAE 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ITAE_HUMAN, P38570: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with ITGAE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ITGAE About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal Adhesion0.65
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35


    Find genes that share SuperPaths with ITGAE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGAE (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGAE
        Focal Adhesion
    Integrin-mediated cell adhesion
    E-cadherin signaling in the nascent adherens junction

    1 Reactome Pathway for ITGAE
        Integrin cell surface interactions


    1 Kegg Pathway  (Kegg details for ITGAE):
        Regulation of actin cytoskeleton

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITGAE
    Interactions:

        Search GeneGlobe Interaction Network for ITGAE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGAE (P385702, 3 ENSP000002630874) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHFRQ96EP12, 3, ENSP000003205574MINT-65140 I2D: score=4 STRING: ENSP00000320557
    EEDO755303, ENSP000002633604I2D: score=5 STRING: ENSP00000263360
    ITGB7P260103, ENSP000002670824I2D: score=3 STRING: ENSP00000267082
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CTNNA1ENSP000003046694STRING: ENSP00000304669
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with ITGAE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGAE (ITAE)

    1 Novoseek inferred chemical compound relationship for ITGAE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha e 86.9 4 11867163 (2), 10737767 (1), 15093560 (1)



    Find genes that share compounds with ITGAE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ITGAE gene: 
    NM_002208.4  

    Unigene Cluster for ITGAE:

    Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
    Hs.513867  [show with all ESTs]
    Unigene Representative Sequence: L25851
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572179(uc002fwn.4) ENST00000263087(uc002fwo.4) ENST00000572433
    ENST00000571937 ENST00000570415 ENST00000570360 ENST00000571185 ENST00000574026
    ENST00000572121
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGAE using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITGAE
    SwitchGear 3'UTR luciferase reporter plasmidITGAE 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGAE
    Predesigned siRNA for gene silencing in human, mouse, rat ITGAE
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAE (see all 7)
    OriGene ORF clones in mouse, rat for ITGAE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAE (NM_002208)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAE
      QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
      QuantiFast Probe-based Assays in human, mouse, rat ITGAE

    Additional mRNA sequence: 

    AF289864.1 AK097567.1 BC113436.1 BC117207.1 L25851.2 

    12 DOTS entries:

    DT.441861  DT.92426789  DT.75107961  DT.97768637  DT.87002140  DT.95368901  DT.120992626  DT.92426792 
    DT.95198501  DT.95368899  DT.97823164  DT.402551 

    Selected AceView cDNA sequences (see all 158):

    AA195282 AI824883 BF056043 AI205492 AK097567 W74608 CA309601 CA867593 
    BE504059 AI817823 AA569942 CA438028 BE504062 BE501043 AW002498 CD678015 
    AW027978 BE550470 CF130501 BG758439 BM825485 AI185633 BE218259 AI127585 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ITGAE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCTGTTGG
    ITGAE Expression
    About this image


    ITGAE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
    ITGAE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGAE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513867

    UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
    Tissue specificity: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are
    located between mucosal epithelial cells

        Custom PCR Arrays for ITGAE
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAE
    QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
    QuantiFast Probe-based Assays in human, mouse, rat ITGAE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for ITGAE gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgae1 , 5 integrin alpha E, epithelial-associated1, 5 78.81(n)1
    70.63(a)1
      11 (45.22 cM)5
    164071  NM_008399.21  NP_032425.21 
     730905835 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    24(a)
    many ↔ many
    GL343516.1(357601-389538)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367051 integrin alpha-E-like 48.06(n)
    36.83(a)
      100536705  XM_003200028.2  XP_003200076.2 


    ENSEMBL Gene Tree for ITGAE (if available)
    TreeFam Gene Tree for ITGAE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ITGAE gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  

    Find genes that share paralogs with ITGAE           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ITGAE
    PGOHUM00000243168


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ITGAE (see all 2279)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs711533901,2
    C--3514757(+) TTTCC-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs668349601,2
    C--3534552(+) TTGTA-/T/TT  
            
    TTTTT
    1 -- int11NA 2
    rs65027411,2
    C,A--3617456(+) gacctC/Tgtgat 1 -- ds50010--------
    rs1849425481,2
    --3617543(+) TTTGAA/GATGGA 1 -- ds50010--------
    rs1901467471,2
    --3617591(+) ATCTCA/GGCTCA 1 -- ds50010--------
    rs80686181,2
    C,F,A--3617667(+) caggcG/Acccgc 1 -- ds50013Minor allele frequency- A:0.50NA 6
    rs80670471,2
    C--3617727(+) atgttA/Ggctag 1 -- ds50010--------
    rs129386231,2
    C,F--3617730(+) TTGGCT/CAGGAT 1 -- ds50015Minor allele frequency- C:0.40NA 10
    rs98994131,2
    C,F,A--3617736(+) AGGATA/GGTCTC 1 -- ds50015Minor allele frequency- G:0.40NA 10
    rs129478261,2
    C,F--3617778(+) GCCTCC/TCAAAG 1 -- ds50016Minor allele frequency- T:0.42NA CSA 12

    HapMap Linkage Disequilibrium report for ITGAE (3617919 - 3704537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ITGAE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv996976CNV Deletion20482838
    esv1749908CNV Insertion17803354
    esv1004185CNV Insertion20482838
    nsv1949CNV Insertion18451855
    nsv833342CNV Loss17160897
    nsv907571CNV Loss21882294
    esv24017CNV Loss19812545
    nsv1948CNV Loss18451855
    nsv907570CNV Gain21882294
    nsv469791CNV Complex16826518

    Human Gene Mutation Database (HGMD): ITGAE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAE
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604682    OMIM disorders: --

    2 diseases for ITGAE:    
    About MalaCards
    nephropathic cystinosis    cystinosis

    4 diseases from the University of Copenhagen DISEASES database for ITGAE:
    Hairy cell leukemia     Lymphoma     Kawasaki disease     Celiac disease

    Find genes that share disorders with ITGAE           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGAE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell cutaneous 40.1 1 8864917 (1)
    mycosis fungoides 38.6 1 7977645 (1)
    inflammatory bowel diseases 29.3 2 14532999 (2)
    lymphoma 25.2 2 7977645 (1), 8780585 (1)
    lymphoma t-cell 24.9 1 8780585 (1)
    pancreatic cancer 11.3 2 12434297 (2)
    necrosis 1.57 1 12434297 (1)
    tumors 0.97 2 8780585 (1), 19638592 (1)
    leukemia 0 1 1697100 (1)
    renal disease 0 1 12717221 (1)

    Genetic Association Database (GAD): ITGAE
    Human Genome Epidemiology (HuGE) Navigator: ITGAE (8 documents)

    Export disorders for ITGAE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ITGAE gene, integrated from 10 sources (see all 96):
    (articles sorted by number of sources associating them with ITGAE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. (PubMed id 8119947)1, 2, 3, 9 Shaw S.K....Parker C.M. (J. Biol. Chem. 1994)
    2. A family of beta 7 integrins on human mucosal lymphocytes. (PubMed id 1542691)1, 2, 9 Parker C.M.... Brenner M.B. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    3. Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients. (PubMed id 20417566)1, 4 Liu Y.H....Tsai F.J. (Ophthalmology 2010)
    4. Dengue hemorrhagic fever is associated with polymorphisms in JAK1. (PubMed id 20588308)1, 4 Silva L.K....Teixeira M.G. (Eur. J. Hum. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)
    7. Effect of variation in ITGAE on risk of sarcoidosis, CD103 expression, and chest radiography. (PubMed id 19604725)1, 4 Heron M....Van den Bosch J.M. (Clin. Immunol. 2009)
    8. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (Cancer Res. 2008)
    9. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    10. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)1, 4 Shiffman D....Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3682 HGNC: 6147 AceView: ITGAE Ensembl:ENSG00000083457 euGenes: HUgn3682
    ECgene: ITGAE Kegg: 3682 H-InvDB: ITGAE

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ITGAE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ITGAE gene:
    Search GeneIP for patents involving ITGAE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAE
     
     EMD Millipore genomic analysis products

      
     Antibodies for ITGAE (Integrin alpha E/CD103)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for ITGAE (Integrin alpha E/CD103)   Proteome Profiler Antibody Arrays for ITGAE (Integrin alpha E/CD103)  
     OriGene Antibodies for ITGAE   OriGene RNAi products in human, mouse, rat for ITGAE  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGAE  
     OriGene MassSpec for ITGAE   OriGene clones in human, mouse for ITGAE  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGAE   OriGene Purified Protein for ITGAE  
     OriGene ORF clones in mouse, rat for ITGAE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGAE   OriGene Custom Protein Services for ITGAE  

     
     
     Block miRNA regulation of human, mouse, rat ITGAE using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ITGAE
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGAE Predesigned siRNA for gene silencing in human, mouse, rat ITGAE
     QuantiFast Probe-based Assays in human, mouse, rat ITGAE QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
     Custom PCR Arrays for ITGAE Search Chromatin IP Primers for ITGAE
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGAE  Search GeneGlobe Interaction Network for ITGAE
     Regulatory tfbs in ITGAE promoter
     GenScript Custom Purified and Recombinant Proteins Services for ITGAE GenScript cDNA clones with any tag delivered in your preferred vector for ITGAE
     GenScript Custom Assay Services for ITGAE GenScript Custom overexpressing Cell Line Services for ITGAE
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ITGAE (ITAE)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ITGAE antibodies
     ITGAE proteins
     ITGAE lysates
     Antibodies for ITGAE
     See all of Abcam's Antibodies, Kits and Proteins for ITGAE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ITGAE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE
     SwitchGear 3'UTR luciferase reporter plasmids for ITGAE
     SwitchGear Promoter luciferase reporter plasmids for ITGAE
     ThermoFisher Antibodies for ITGAE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE
     Browse compounds at ApexBio
     Search Addgene for plasmids for ITGAE
      Search eBioscience for proteins for ITGAE
      Search eBioscience for elisas for ITGAE
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ITGAE
     antibodies-online antibodies for ITGAE (189 products)
     antibodies-online kits for ITGAE (2 products)
     antibodies-online peptides for ITGAE
     antibodies-online proteins for ITGAE (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGAE gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4