Aliases for ITGAE Gene
External Ids for ITGAE Gene
Previous GeneCards Identifiers for ITGAE Gene
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGAE Gene
ITGAE (Integrin Subunit Alpha E) is a Protein Coding gene. Diseases associated with ITGAE include Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. An important paralog of this gene is ITGAM.
UniProtKB/Swiss-Prot for ITGAE Gene
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers.