Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGAE Gene

protein-coding   GIFtS: 60
GCID: GC17M003617

integrin, alpha E (antigen CD103, human mucosal lymphocyte...

 Explore 35 diseases affiliated with
ITGAE via our new
 Human Malady Compendium 
Biological research products
for ITGAE
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Integrin, Alpha E (Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha
Polypeptide)1 2
     HML-1 Antigen2 3
CD1031 2     Antigen CD103, Human Mucosal Lymphocyte Antigen 1; Alpha Polypeptide2
HUMINAE1 2     Integrin Alpha-E2
Integrin Alpha-IEL2 3     CD103 Antigen3
Mucosal Lymphocyte 1 Antigen2 3     

External Ids:    HGNC: 61471   Entrez Gene: 36822   Ensembl: ENSG000000834577   OMIM: 6046825   UniProtKB: P385703   

Export aliases for ITGAE gene to outside databases

Previous GC identifers: GC17M003930 GC17M003960 GC17M003568 GC17M003824 GC17M003564 GC17M003513


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGAE:
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes
an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding
disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin
binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human
intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory
molecule for IEL activation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes
to epithelial cell monolayers

Gene Wiki entry for ITGAE


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGAE gene promoter:
         Nkx3-1   RFX1   Nkx3-1 v4   AML1a   Nkx3-1 v1   Nkx3-1 v2   MZF-1   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGAE promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGAE

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13

ITGAE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAE gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M003617:  view genomic region     (about GC identifiers)

Start:
3,617,919 bp from pter      End:
3,704,537 bp from pter
Size:
86,619 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570 (See protein sequence)
Recommended Name: Integrin alpha-E precursor  
Size: 1179 amino acids; 130159 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked
by a disulfide bond. Alpha-E associates with beta-7
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q17RS6 Q9NZU9

Explore the universe of human proteins at neXtProt for ITGAE: NX_P38570

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P38570

  • ITGAE Protein expression data from MOPED and PaxDb:    About this image 
    ITGAE Protein Expression
    REFSEQ proteins: NP_002199.3  
    ENSEMBL proteins: 
     ENSP00000263087   ENSP00000467977  
    Reactome Protein details: P38570
    Human Recombinant Protein Products for ITGAE: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ITGAE
    OriGene Protein Over-expression Lysate: ITGAE
    OriGene Custom Protein Services for ITGAE 
    GenScript Custom Purified and Recombinant Proteins Services for ITGAE
    Novus Biologicals ITGAE Protein
    Novus Biologicals ITGAE Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--

    ITGAE for ontologies           About GeneDecksing



    ITGAE Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAE
    R&D Systems Antibodies for ITGAE (Integrin alpha E/CD103)
    OriGene Antibodies: ITGAE
    OriGene Custom Antibody Services for ITGAE 
    GenScript Custom Superior Antibodies Services for ITGAE
    Novus Biologicals ITGAE Antibodies
    Abcam antibodies for ITGAE 
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for ITGAE

    Assay Products for ITGAE: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for ITGAE (Integrin alpha E/CD103)
    GenScript Custom Assay Services for ITGAE
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ITGAE for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000413 Integrin_alpha
     IPR013519 Int_alpha_beta-p
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry P38570

    ProtoNet protein and cluster: P38570

    4 Blocks protein families:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAE_HUMAN, P38570
    Function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes
    to epithelial cell monolayers
    Induction: Integrin alpha-E/beta-7 is induced by TGFB1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0046872metal ion binding IEA--
         
    ITGAE for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itgae):
     hematopoietic system  immune system 

    ITGAE for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Itgaetm1Cmp for ITGAE
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITGAE 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: ITGAE
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGAE
    SwitchGear 3'UTR luciferase reporter plasmidITGAE 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAE (see all 7)
    OriGene shRNA RFP: ITGAE
    OriGene siRNA: ITGAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAE
    Sirion Biotech Custom design and validation of potent shRNA sequences against ITGAE 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAE
    Sirion Biotech Customized adenovirus for overexpression of ITGAE 
    Sirion Biotech Customized adenovirus for potent knockdown of ITGAE

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAE (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ITGAE (NM_002208)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAE
    Search LifeMap BioReagents cell lines for ITGAE
    Sirion Biotech Customized stable knockdown cell line services for ITGAE 
    Sirion Biotech Customized inducible knockdown cell line services for ITGAE
    Sirion Biotech Customized stable overexpressing cell line services for ITGAE
    Sirion Biotech Customized inducible overexpressing cell line services for ITGAE

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/19 super-pathways (see all 19About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    Integrin Pathway1.00
    UPA-UPAR Pathway0.51
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    2Rho Family GTPases
    Rho Family GTPases1.00
    MAPK Signaling0.51
    ERK Signaling0.61
    ILK Signaling0.45
    Molecular Mechanisms of Cancer0.51
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.52
    Rac1 Pathway0.58
    Rap1 Pathway0.42
    Glioma Invasiveness0.54
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex1.00
    RhoA Pathway0.35
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.34
    5Focal Adhesion
    Focal Adhesion1.00
    HGF Pathway0.24
    Integrin-mediated cell adhesion0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/34 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAE (see all 34)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGAE 
        Focal Adhesion
    Integrin-mediated cell adhesion
    E-cadherin signaling in the nascent adherens junction

    2        Reactome Pathways for ITGAE
        Integrin cell surface interactions
    Signal Transduction


    1         Kegg Pathway  (Kegg details for ITGAE):
        Regulation of actin cytoskeleton


    ITGAE for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITGAE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for ITGAE (P385702, 3 ENSP000002630874) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHFRQ96EP12, 3, ENSP000003205574MINT-65140 I2D: score=4 STRING: ENSP00000320557
    EEDO755303, ENSP000002633604I2D: score=5 STRING: ENSP00000263360
    ITGB7P260103, ENSP000002670824I2D: score=3 STRING: ENSP00000267082
    CDH1P128303, ENSP000002617694I2D: score=1 STRING: ENSP00000261769
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    ITGAE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGAE for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGAE
    1 Novoseek chemical compound relationship for ITGAE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha e 86.9 4 11867163 (2), 10737767 (1), 15093560 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGAE / ITAE 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGAE gene: 
    NM_002208.4  

    Unigene Cluster for ITGAE:

    Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
    Hs.513867  [show with all ESTs]
    Unigene Representative Sequence: L25851
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572179(uc002fwn.4) ENST00000263087(uc002fwo.4) ENST00000572433
    ENST00000571937 ENST00000570415 ENST00000570360 ENST00000571185 ENST00000574026
    ENST00000572121

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ITGAE
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAE
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGAE
    SwitchGear 3'UTR luciferase reporter plasmidITGAE 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAE (see all 7)
    OriGene shRNA RFP: ITGAE
    OriGene siRNA: ITGAE
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAE
    Sirion Biotech Custom design and validation of potent shRNA sequences against ITGAE 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAE (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAE
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ITGAE (NM_002208)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAE
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGAE
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAE
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAE

    Additional cDNA sequence: 

    AF289864.1 AK097567.1 BC113436.1 BC117207.1 L25851.2 

    12 DOTS entries:

    DT.441861  DT.92426789  DT.75107961  DT.97768637  DT.87002140  DT.95368901  DT.120992626  DT.92426792 
    DT.95198501  DT.95368899  DT.97823164  DT.402551 

    24/158 AceView cDNA sequences (see all 158):

    BM825485 CA309360 AK097567 CD678015 BF449000 BF056043 AI652636 CA438028 
    BE501043 AA195282 AI205492 AA503512 AI132981 AF289864 BE550470 BU739725 
    AI824883 AW002498 CD369106 BG758439 BE504062 AA569942 AI127585 CF130501 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGAE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCTGTTGG
    ITGAE Expression
    About this image
    See ITGAE Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGAE

    SOURCE GeneReport for Unigene cluster: Hs.513867

    UniProtKB/Swiss-Prot: ITAE_HUMAN, P38570
    Tissue specificity: Expressed on a subclass of T-lymphocytes known as intra-epithelial lymphocytes which are located
    between mucosal epithelial cells

        SABiosciences Custom PCR Arrays for ITGAE
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGAE
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAE
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAE
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGAE gene from 3/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    15(a)
    possible ortholog
    GL343516.1(252432-271527)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005367051 integrin alpha-E-like 48.75(n)
    38.06(a)
      100536705  XM_003200028.1  XP_003200076.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scb6
    alphaPS46
    (see all 3)
    alphaPS4
    (see all 3)
    16(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(11136290-11146003)
    2R(11146272-11150371)


    ENSEMBL Gene Tree for ITGAE (if available)
    TreeFam Gene Tree for ITGAE (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGAE gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  

    ITGAE for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ITGAE
    PGOHUM00000243168


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1919 NCBI SNPs in ITGAE are shown (see all 1919    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs65027411,2
    C,A--3617456(+) gacctC/Tgtgat 1 -- ds50010--------
    rs1849425481,2
    --3617543(+) TTTGAA/GATGGA 1 -- ds50010--------
    rs1901467471,2
    --3617591(+) ATCTCA/GGCTCA 1 -- ds50010--------
    rs80686181,2
    C,F,A--3617667(+) CAGGCG/ACCCGC 1 -- ds50013Minor allele frequency- A:0.50NA 6
    rs80670471,2
    C--3617727(+) atgttA/Ggctag 1 -- ds50010--------
    rs129386231,2
    C,F--3617730(+) TTGGCT/CAGGAT 1 -- ds50015Minor allele frequency- C:0.40NA 10
    rs98994131,2
    C,F,A--3617736(+) AGGATA/GGTCTC 1 -- ds50015Minor allele frequency- G:0.40NA 10
    rs129478261,2
    C,F--3617778(+) GCCTCC/TCAAAG 1 -- ds50016Minor allele frequency- T:0.42NA CSA 12
    rs98988221,2
    C,F,A--3617799(+) acaggC/Tgtgag 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs129457541,2
    C,F--3617816(+) TGCCCG/AGCCAC 1 -- ds50017Minor allele frequency- A:0.44NA CSA EA 250

    HapMap Linkage Disequilibrium report for ITGAE (3617919 - 3704537 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ITGAE
         2 CNVs: 4982 67113
    Human Gene Mutation Database (HGMD): ITGAE

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGAE
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ITGAE for disorders           About GeneDecksing

    OMIM gene information: 604682    OMIM disorders: --

    20/35 diseases for ITGAE (see all 35):    About MalaCards
    splenic marginal zone lymphoma    nephropathic cystinosis    mycosis fungoides    dengue hemorrhagic fever
    hemorrhagic fever    inflammatory bowel disease    cystinosis    b-cell lymphomas
    hairy cell leukemia    adult t-cell leukemia    chronic lymphocytic leukemia    chronic myeloid leukemia
    pulmonary sarcoidosis    lymphocytic leukemia    leukemia/lymphoma    myeloid leukemia
    t-cell leukemia    cutaneous t cell lymphoma    sarcoidosis    leukemia

    3 diseases from the University of Copenhagen DISEASES database for ITGAE:
    Hairy cell leukemia     Lymphoma     Celiac disease

    10/11 Novoseek disease relationships for ITGAE gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell cutaneous 40.1 1 8864917 (1)
    mycosis fungoides 38.6 1 7977645 (1)
    inflammatory bowel diseases 29.3 2 14532999 (2)
    lymphoma 25.2 2 7977645 (1), 8780585 (1)
    lymphoma t-cell 24.9 1 8780585 (1)
    pancreatic cancer 11.3 2 12434297 (2)
    necrosis 1.57 1 12434297 (1)
    tumors 0.97 2 8780585 (1), 19638592 (1)
    leukemia 0 1 1697100 (1)
    renal disease 0 1 12717221 (1)

    Human Genome Epidemiology (HuGE) Navigator: ITGAE (8 documents)

    Export disorders for ITGAE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGAE gene, integrated from 9 sources (see all 94):
    (articles sorted by number of sources associating them with ITGAE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. (PubMed id 8119947)1, 2, 3, 9 Shaw S.K....Parker C.M. (1994)
    2. A family of beta 7 integrins on human mucosal lymphocytes. (PubMed id 1542691)1, 2, 9 Parker C.M.... Brenner M.B. (1992)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion. (PubMed id 10673275)1, 2 Touchman J.W....Green E.D. (2000)
    5. The role of alpha and beta chains in ligand recognition by beta 7 integrins. (PubMed id 10837471)1, 2 Higgins J.M.G....Brenner M.B. (2000)
    6. CD103 is a marker for alloantigen-induced regulatory CD8+ T cells. (PubMed id 16920912)1, 9 Uss E....ten Berge I.J. (2006)
    7. T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy? (PubMed id 12434297)1, 9 French J.J....Kirby J.A. (2002)
    8. Differential expression of homing receptor CD103 on lamina propria lymphocytes and association of CD103 with epithelial adhesion molecules in inflammatory bowel disease. (PubMed id 14532999)1, 9 Oshitani N....Arakawa T. (2003)
    9. Role of integrin CD103 in promoting destruction of renal allografts by CD8 T cells. (PubMed id 15196058)1, 9 Hadley G. (2004)
    10. E-cadherin-mediated interactions of thymic epithelial cells with CD103+ thymocytes lead to enhanced thymocyte cell proliferation. (PubMed id 12414996)1, 9 Kutlesa S....Klein G. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3682 HGNC: 6147 AceView: ITGAE Ensembl:ENSG00000083457 euGenes: HUgn3682
    ECgene: ITGAE Kegg: 3682 H-InvDB: ITGAE

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGAE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGAE gene:
    Search GeneIP for patents involving ITGAE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGAE
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ITGAE (Integrin alpha E/CD103)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents for ITGAE (Integrin alpha E/CD103)  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ITGAE   OriGene shRNA RFP for ITGAE  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGAE   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGAE  
     OriGene Protein Over-expression Lysate for ITGAE   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ITGAE   OriGene 3'-UTR Clone for ITGAE  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAE   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGAE  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ITGAE   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGAE   OriGene Custom Protein Services for ITGAE  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGAE
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGAE
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAE
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAE
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAE
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAE
     GenScript Custom Purified and Recombinant Proteins Services for ITGAE GenScript cDNA clones with any tag delivered in your preferred vector for ITGAE
     GenScript Custom Assay Services for ITGAE GenScript Custom Superior Antibodies Services for ITGAE
     GenScript Custom overexpressing Cell Line Services for ITGAE CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ITGAE promoter
     Search Chromatin IP Primers for ITGAE
     RT2 qPCR Primer Assay in human, mouse, rat ITGAE
     Search GNC Networks for ITGAE
     SABiosciences PCR Arrays including human, mouse, rat ITGAE
     Search Tocris compounds for ITGAE
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITGAE antibodies
     ITGAE proteins
     ITGAE lysates
     Antibodies for ITGAE
     See all of Abcam's Antibodies, Kits and Proteins for ITGAE
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for ITGAE
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAE
     SwitchGear 3'UTR luciferase reporter plasmids for ITGAE
     SwitchGear Promoter luciferase reporter plasmids for ITGAE
     ThermoFisher Antibodies for ITGAE
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAE
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ITGAE
    Sirion Biotech Customized:
     stable knockdown cell line services for ITGAE
     inducible knockdown cell line services for ITGAE
     design and validation of potent shRNA sequences against ITGAE
     adenovirus for potent knockdown of ITGAE
     adenovirus for overexpression of ITGAE
     stable overexpressing cell line services for ITGAE
     inducible overexpressing cell line services for ITGAE
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGAE gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4