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Aliases for ITGAD Gene

Aliases for ITGAD Gene

  • Integrin, Alpha D 2 3
  • CD11 Antigen-Like Family Member D 3 4
  • Leukointegrin Alpha D 3 4
  • CD11D 3 6
  • ADB2 3 4
  • Integrin Alpha-D 3
  • CD11d Antigen 4

External Ids for ITGAD Gene

Summaries for ITGAD Gene

GeneCards Summary for ITGAD Gene

ITGAD (Integrin, Alpha D) is a Protein Coding gene. Diseases associated with ITGAD include chronic monocytic leukemia. Among its related pathways are Regulation of actin cytoskeleton and TGF-Beta Pathway. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGAD Gene

  • Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood

Gene Wiki entry for ITGAD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAD Gene

Genomics for ITGAD Gene

Genomic Location for ITGAD Gene

Start:
31,393,312 bp from pter
End:
31,426,505 bp from pter
Size:
33,194 bases
Orientation:
Plus strand

Genomic View for ITGAD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAD Gene

Regulatory Elements for ITGAD Gene

Proteins for ITGAD Gene

  • Protein details for ITGAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13349-ITAD_HUMAN
    Recommended name:
    Integrin alpha-D
    Protein Accession:
    Q13349
    Secondary Accessions:
    • Q15575
    • Q15576

    Protein attributes for ITGAD Gene

    Size:
    1161 amino acids
    Molecular mass:
    126758 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2
    SequenceCaution:
    • Sequence=AAB60634.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

neXtProt entry for ITGAD Gene

Proteomics data for ITGAD Gene at MOPED

Post-translational modifications for ITGAD Gene

  • Glycosylation at Asn59, Asn87, Asn99, Asn391, Asn690, Asn732, Asn872, Asn956, and Asn1045

Other Protein References for ITGAD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGAD Gene

Domains for ITGAD Gene

Gene Families for ITGAD Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

UniProtKB/Swiss-Prot:

ITAD_HUMAN
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage:
    • Q13349
  • Contains 1 VWFA domain.:
    • Q13349
Family:
  • Belongs to the integrin alpha chain family.:
    • Q13349
Similarity:
  • Contains 7 FG-GAP repeats.:
    • Q13349
genes like me logo Genes that share domains with ITGAD: view

Function for ITGAD Gene

Molecular function for ITGAD Gene

GENATLAS Biochemistry: integrin,alpha D,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,arrayed in tandem with ITGAX (CD11C),dimerizing with ITGB2 in fibrinogen,C3b receptor
UniProtKB/Swiss-Prot Function: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood

Gene Ontology (GO) - Molecular Function for ITGAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGAD: view
genes like me logo Genes that share phenotypes with ITGAD: view

Animal Models for ITGAD Gene

MGI Knock Outs for ITGAD:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ITGAD Gene

Localization for ITGAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAD Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGAD Gene COMPARTMENTS Subcellular localization image for ITGAD gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex TAS 20187620
GO:0009986 cell surface IC 20563599
genes like me logo Genes that share ontologies with ITGAD: view

Pathways for ITGAD Gene

genes like me logo Genes that share pathways with ITGAD: view

Pathways by source for ITGAD Gene

Gene Ontology (GO) - Biological Process for ITGAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 9841932
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0034113 heterotypic cell-cell adhesion IMP 20563599
GO:0050798 activated T cell proliferation IEA --
genes like me logo Genes that share ontologies with ITGAD: view

Transcripts for ITGAD Gene

mRNA/cDNA for ITGAD Gene

(15) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITGAD Gene

Integrin, alpha D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: - - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1:
SP2:
SP3:

Relevant External Links for ITGAD Gene

GeneLoc Exon Structure for
ITGAD
ECgene alternative splicing isoforms for
ITGAD

Expression for ITGAD Gene

mRNA expression in normal human tissues for ITGAD Gene

mRNA differential expression in normal tissues according to GTEx for ITGAD Gene

This gene is overexpressed in Spleen (32.5) and Whole Blood (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGAD Gene

SOURCE GeneReport for Unigene cluster for ITGAD Gene Hs.679163

mRNA Expression by UniProt/SwissProt for ITGAD Gene

Q13349-ITAD_HUMAN
Tissue specificity: Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages
genes like me logo Genes that share expressions with ITGAD: view

Orthologs for ITGAD Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAD 36
  • 95.63 (n)
  • 94.71 (a)
ITGAD 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGAD 36
  • 82.14 (n)
  • 75.06 (a)
ITGAD 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 77 (a)
OneToMany
ITGAD 36
  • 84.09 (n)
  • 80.21 (a)
ITGAD 37
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Itgad 36
  • 79.47 (n)
  • 73.48 (a)
Itgad 16
Itgad 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
-- 37
  • 60 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
-- 37
  • 54 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Itgad 36
  • 79.72 (n)
  • 73.89 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 46 (a)
ManyToMany
-- 37
  • 44 (a)
ManyToMany
-- 37
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-32n7.4 37
  • 36 (a)
ManyToMany
Species with no ortholog for ITGAD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAD Gene

ENSEMBL:
Gene Tree for ITGAD (if available)
TreeFam:
Gene Tree for ITGAD (if available)

Paralogs for ITGAD Gene

Selected SIMAP similar genes for ITGAD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITGAD: view

Variants for ITGAD Gene

Sequence variations from dbSNP and Humsavar for ITGAD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2230430 -- 31,411,497(+) CCAGC(A/G)TCAGC reference, missense
rs2454907 -- 31,393,181(+) CCAGG(A/G)TGTTG upstream-variant-2KB
rs2454908 -- 31,399,864(-) TGCCC(A/G)CCACC intron-variant
rs2454909 -- 31,399,627(-) AACCT(A/G)GCTTC intron-variant
rs2454910 -- 31,398,670(-) cccat(C/T)tctac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAD Gene

Variant ID Type Subtype PubMed ID
nsv833194 CNV Loss 17160897
esv2714194 CNV Deletion 23290073
nsv905747 CNV Gain 21882294
esv25470 CNV Gain 19812545
dgv2673n71 CNV Loss 21882294
nsv905751 CNV Loss 21882294

Relevant External Links for ITGAD Gene

HapMap Linkage Disequilibrium report
ITGAD

Disorders for ITGAD Gene

(1) University of Copenhagen DISEASES for ITGAD Gene

genes like me logo Genes that share disorders with ITGAD: view

No data available for UniProtKB/Swiss-Prot for ITGAD Gene

Publications for ITGAD Gene

  1. Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. (PMID: 8666289) Wong D.A. … Springer T.A. (Gene 1996) 2 3 4
  2. Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. (PMID: 9598326) Shelley C.S. … Arnaout M.A. (Genomics 1998) 2 3 23
  3. Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins. (PMID: 12429998) Noti J.D. (Int. J. Mol. Med. 2002) 3 23
  4. A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM- 3. (PMID: 8777714) Van der Vieren M. … Gallatin W.M. (Immunity 1995) 3 4
  5. Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM- 1). (PMID: 9841932) Grayson M.H. … Bochner B.S. (J. Exp. Med. 1998) 3 4

Products for ITGAD Gene

Sources for ITGAD Gene

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