Aliases for ITGAD Gene
External Ids for ITGAD Gene
Previous GeneCards Identifiers for ITGAD Gene
This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for ITGAD Gene
ITGAD (Integrin Subunit Alpha D) is a Protein Coding gene. Diseases associated with ITGAD include Chronic Monocytic Leukemia. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. An important paralog of this gene is ITGAX.
UniProtKB/Swiss-Prot for ITGAD Gene
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.