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Aliases for ITGAD Gene

Aliases for ITGAD Gene

  • Integrin Subunit Alpha D 2 3 5
  • CD11 Antigen-Like Family Member D 3 4
  • Leukointegrin Alpha D 3 4
  • ADB2 3 4
  • Beta-2 Integrin AlphaD Subunit 3
  • Integrin, Alpha D 2
  • Integrin Alpha-D 3
  • CD11d Antigen 4
  • CD11D 3

External Ids for ITGAD Gene

Previous GeneCards Identifiers for ITGAD Gene

  • GC16U990033
  • GC16P031901
  • GC16P031401
  • GC16P031440
  • GC16P031312
  • GC16P028964

Summaries for ITGAD Gene

Entrez Gene Summary for ITGAD Gene

  • This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for ITGAD Gene

ITGAD (Integrin Subunit Alpha D) is a Protein Coding gene. Diseases associated with ITGAD include Chronic Monocytic Leukemia. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Apoptotic Pathways in Synovial Fibroblasts. An important paralog of this gene is ITGAX.

UniProtKB/Swiss-Prot for ITGAD Gene

  • Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Gene Wiki entry for ITGAD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGAD Gene

Genomics for ITGAD Gene

Regulatory Elements for ITGAD Gene

Enhancers for ITGAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F031507 1.1 ENCODE 5.2 +115.5 115507 3.3 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF143 ENSG00000261475 ENSG00000260267 VN1R64P ENSG00000261648 VN1R65P ENSG00000260568 VN1R3 NDUFA3P6 RBM22P13 IGHV3OR16-9
GH16F031483 1.1 Ensembl ENCODE 4.2 +91.6 91571 1.7 ELF3 MLX ARID4B DMAP1 RAD21 RARA MIXL1 EGR2 THAP11 KLF11 LOC105371171 ZNF843 ITGAD SLC5A2
GH16F031386 1.1 Ensembl ENCODE 0.4 -6.6 -6607 0.9 TBP MXI1 JUN MAX SIN3A BMI1 ZIC2 ZFHX2 GATA3 SCRT2 ENSG00000260304 ITGAX PYCARD COX6A2 HSD3B7 SETD1A PRSS36 STX4 STX1B ZNF764
GH16F031385 0.6 Ensembl ENCODE 0.4 -7.3 -7341 0.2 FOS ITGAX PYCARD COX6A2 HSD3B7 SETD1A PRSS36 STX4 STX1B GC16M031380 ITGAD
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITGAD on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGAD Gene

Chromosome:
16
Start:
31,393,241 bp from pter
End:
31,426,513 bp from pter
Size:
33,273 bases
Orientation:
Plus strand

Genomic View for ITGAD Gene

Genes around ITGAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGAD Gene

Proteins for ITGAD Gene

  • Protein details for ITGAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13349-ITAD_HUMAN
    Recommended name:
    Integrin alpha-D
    Protein Accession:
    Q13349
    Secondary Accessions:
    • Q15575
    • Q15576

    Protein attributes for ITGAD Gene

    Size:
    1161 amino acids
    Molecular mass:
    126758 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.
    SequenceCaution:
    • Sequence=AAB60634.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

neXtProt entry for ITGAD Gene

Post-translational modifications for ITGAD Gene

  • Glycosylation at Asn 59, Asn 87, Asn 99, Asn 391, Asn 690, Asn 732, Asn 872, Asn 956, and Asn 1045
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITGAD Gene

Domains & Families for ITGAD Gene

Gene Families for ITGAD Gene

Graphical View of Domain Structure for InterPro Entry

Q13349

UniProtKB/Swiss-Prot:

ITAD_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGAD: view

Function for ITGAD Gene

Molecular function for ITGAD Gene

GENATLAS Biochemistry:
integrin,alpha D,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,arrayed in tandem with ITGAX (CD11C),dimerizing with ITGB2 in fibrinogen,C3b receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Gene Ontology (GO) - Molecular Function for ITGAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGAD: view
genes like me logo Genes that share phenotypes with ITGAD: view

Animal Models for ITGAD Gene

MGI Knock Outs for ITGAD:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ITGAD Gene

Localization for ITGAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGAD Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGAD gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ITGAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex TAS 20187620
GO:0009986 cell surface IC 20563599
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ITGAD: view

Pathways & Interactions for ITGAD Gene

genes like me logo Genes that share pathways with ITGAD: view

Gene Ontology (GO) - Biological Process for ITGAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response NAS 9841932
GO:0007155 cell adhesion IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0034113 heterotypic cell-cell adhesion IMP 20563599
genes like me logo Genes that share ontologies with ITGAD: view

No data available for SIGNOR curated interactions for ITGAD Gene

Transcripts for ITGAD Gene

mRNA/cDNA for ITGAD Gene

(16) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ITGAD Gene

Integrin, alpha D:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGAD Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: - - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
SP1:
SP2:
SP3:

Relevant External Links for ITGAD Gene

GeneLoc Exon Structure for
ITGAD
ECgene alternative splicing isoforms for
ITGAD

Expression for ITGAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGAD Gene

mRNA differential expression in normal tissues according to GTEx for ITGAD Gene

This gene is overexpressed in Spleen (x32.5) and Whole Blood (x7.1).

Protein differential expression in normal tissues from HIPED for ITGAD Gene

This gene is overexpressed in Blymphocyte (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGAD Gene



Protein tissue co-expression partners for ITGAD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGAD Gene:

ITGAD

SOURCE GeneReport for Unigene cluster for ITGAD Gene:

Hs.679163

mRNA Expression by UniProt/SwissProt for ITGAD Gene:

Q13349-ITAD_HUMAN
Tissue specificity: Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
genes like me logo Genes that share expression patterns with ITGAD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ITGAD Gene

Orthologs for ITGAD Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGAD 34 35
  • 95.63 (n)
dog
(Canis familiaris)
Mammalia ITGAD 34 35
  • 84.09 (n)
-- 35
  • 77 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ITGAD 34 35
  • 82.14 (n)
rat
(Rattus norvegicus)
Mammalia Itgad 34
  • 79.72 (n)
mouse
(Mus musculus)
Mammalia Itgad 34 16 35
  • 79.47 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 54 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 45 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-32n7.4 35
  • 36 (a)
ManyToMany
Species where no ortholog for ITGAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGAD Gene

ENSEMBL:
Gene Tree for ITGAD (if available)
TreeFam:
Gene Tree for ITGAD (if available)

Paralogs for ITGAD Gene

(4) SIMAP similar genes for ITGAD Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITGAD: view

Variants for ITGAD Gene

Sequence variations from dbSNP and Humsavar for ITGAD Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs193921125 Uncertain significance 31,423,169(+) AAATG(A/C)AAGAG nc-transcript-variant, reference, missense
rs111249239 -- 31,424,552(+) GCTGG(C/T)GCTCA nc-transcript-variant, reference, missense
rs111341754 -- 31,403,612(+) AGGCC(C/T)GACGT nc-transcript-variant, reference, missense
rs111401292 -- 31,392,478(+) AGGCT(A/G)CAGTG upstream-variant-2KB
rs11150621 -- 31,395,435(+) TGGCT(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGAD Gene

Variant ID Type Subtype PubMed ID
nsv953804 CNV deletion 24416366
nsv833194 CNV loss 17160897
nsv1066280 CNV gain 25217958
nsv1061980 CNV gain 25217958
nsv1059610 CNV gain 25217958
esv3638400 CNV loss 21293372
esv3638399 CNV loss 21293372
esv3638398 CNV gain 21293372
esv2714194 CNV deletion 23290073
esv25470 CNV gain 19812545
dgv503e214 CNV gain 21293372

Variation tolerance for ITGAD Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.20; 52.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGAD Gene

Disorders for ITGAD Gene

MalaCards: The human disease database

(1) MalaCards diseases for ITGAD Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic monocytic leukemia
  • leukemia, myeloid
- elite association - COSMIC cancer census association via MalaCards
Search ITGAD in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGAD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGAD
genes like me logo Genes that share disorders with ITGAD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGAD Gene

Publications for ITGAD Gene

  1. Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. (PMID: 9598326) Shelley C.S. … Arnaout M.A. (Genomics 1998) 2 3 22 64
  2. Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. (PMID: 8666289) Wong D.A. … Springer T.A. (Gene 1996) 2 3 4 64
  3. Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins. (PMID: 12429998) Noti J.D. (Int. J. Mol. Med. 2002) 3 22 64
  4. Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3. (PMID: 10722744) Noti J.D. … Dillon J.D. (J. Biol. Chem. 2000) 3 4 64
  5. The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1. (PMID: 10438935) Van der Vieren M. … Staunton D.E. (J. Immunol. 1999) 3 4 64

Products for ITGAD Gene

Sources for ITGAD Gene

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