Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGAD Gene

protein-coding   GIFtS: 56
GCID: GC16P031405

Integrin, Alpha D

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha D1 2     CD11D2 5
Leukointegrin Alpha D2 3     Integrin Alpha-D2
ADB22 3     CD11d Antigen3
CD11 Antigen-Like Family Member D2 3     

External Ids:    HGNC: 61461   Entrez Gene: 36812   Ensembl: ENSG000001568867   OMIM: 6024535   UniProtKB: Q133493   

Export aliases for ITGAD gene to outside databases

Previous GC identifers: GC16U990033 GC16P031901 GC16P031401 GC16P031440 GC16P031312 GC16P028964


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ITGAD Gene: 
ITGAD (integrin, alpha D) is a protein-coding gene. Diseases associated with ITGAD include chronic monocytic leukemia, and monocytic leukemia, and among its related super-pathways are Integrin-mediated cell adhesion and FAK1 Signaling. GO annotations related to this gene include metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITAD_HUMAN, Q13349
Function: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic
process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate
matter, and senescent erythrocytes from the blood

Gene Wiki entry for ITGAD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGAD gene promoter:
         AhR   ER-alpha   RP58   Elk-1   p53   CUTL1   LCR-F1   Ik-3   Arnt   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGAD promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGAD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p13.1-p11

ITGAD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGAD gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031405:  view genomic region     (about GC identifiers)

Start:
31,404,633 bp from pter      End:
31,437,826 bp from pter
Size:
33,194 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITAD_HUMAN, Q13349 (See protein sequence)
Recommended Name: Integrin alpha-D precursor  
Size: 1161 amino acids; 126758 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAB60634.1; Type=Miscellaneous discrepancy;
Secondary accessions: Q15575 Q15576

Explore the universe of human proteins at neXtProt for ITGAD: NX_Q13349

Explore proteomics data for ITGAD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13349

  • ITGAD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGAD Protein Expression
    REFSEQ proteins: NP_005344.2  
    ENSEMBL proteins: 
     ENSP00000373854  
    Reactome Protein details: Q13349
    Human Recombinant Protein Products for ITGAD: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGAD
    OriGene Protein Over-expression Lysate for ITGAD
    OriGene MassSpec for ITGAD 
    OriGene Custom Protein Services for ITGAD
    GenScript Custom Purified and Recombinant Proteins Services for ITGAD
    Novus Biologicals ITGAD Protein
    Novus Biologicals ITGAD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS--

    ITGAD for ontologies           About GeneDecksing



    ITGAD Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITGAD
    GenScript Custom Superior Antibodies Services for ITGAD
    Novus Biologicals ITGAD Antibodies
    Search for Antibodies for ITGAD at Abcam
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ITGAD
    Search LSBio for Antibodies for ITGAD 

    Assay Products for ITGAD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGAD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGAD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q13349

    ProtoNet protein and cluster: Q13349

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITAD_HUMAN, Q13349
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGAD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITAD_HUMAN, Q13349
    Function: Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic
    process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate
    matter, and senescent erythrocytes from the blood

         Genatlas biochemistry entry for ITGAD:
    integrin,alpha D,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,arrayed in tandem with ITGAX (CD11C),dimerizing with ITGB2 in fibrinogen,C3b receptor

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ITGAD for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itgad):
     cellular  hematopoietic system  homeostasis/metabolism  immune system 

    ITGAD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGAD: Itgadtm1Bll Itgadtm1.1Zimm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGAD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGAD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGAD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGAD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGAD
    SwitchGear 3'UTR luciferase reporter plasmidITGAD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGAD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGAD
    Sirion Biotech Customized adenovirus for overexpression of ITGAD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGAD (see all 8)
    OriGene ORF clones in mouse, rat for ITGAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAD (NM_005353)
    Sino Biological Human cDNA Clone for ITGAD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAD
    Sirion Biotech Customized lentivirus for stable overexpression of ITGAD 
                         Customized lentivirus expression plasmids for stable overexpression of ITGAD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGAD
    Search LifeMap BioReagents cell lines for ITGAD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGAD About   (see all 19)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66
    RhoA Pathway0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/35 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGAD (see all 35)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 BioSystems Pathways for ITGAD
        Focal Adhesion
    Integrin-mediated cell adhesion


    2        Reactome Pathways for ITGAD
        Integrin cell surface interactions
    Signal Transduction


    1         Kegg Pathway  (Kegg details for ITGAD):
        Regulation of actin cytoskeleton


    ITGAD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGAD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for ITGAD (Q133493 ENSP000003738544) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051073, ENSP000003032424I2D: score=4 STRING: ENSP00000303242
    ICAM3P329423, ENSP000001602624I2D: score=3 STRING: ENSP00000160262
    VCAM1P193203, ENSP000002947284I2D: score=3 STRING: ENSP00000294728
    VTNP040043I2D: score=1 
    FGAENSP000003063614STRING: ENSP00000306361
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response NAS9841932
    GO:0007160cell-matrix adhesion NAS--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0016337cell-cell adhesion NAS--
    GO:0050798activated T cell proliferation IEA--

    ITGAD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGAD (ITAD)

    Search CenterWatch for drugs/clinical trials and news about ITGAD / ITAD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGAD gene: 
    NM_005353.2  

    Unigene Cluster for ITGAD:

    Integrin, alpha D
    Hs.679163  [show with all ESTs]
    Unigene Representative Sequence: AB208945
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389202(uc002ebv.1 uc010cap.1) ENST00000444228(uc010vfl.1 uc002ebw.1)
    ENST00000567308
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGAD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGAD
    SwitchGear 3'UTR luciferase reporter plasmidITGAD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGAD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAD
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGAD (see all 8)
    OriGene ORF clones in mouse, rat for ITGAD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGAD (NM_005353)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGAD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAD
    Sirion Biotech Customized lentivirus for stable overexpression of ITGAD 
                         Customized lentivirus expression plasmids for stable overexpression of ITGAD 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAD

    Additional mRNA sequence: 

    AB208945.1 AK097160.1 AK125016.1 AK301028.1 U37028.1 

    4 DOTS entries:

    DT.92000497  DT.99934184  DT.101958707  DT.95143139 

    3 AceView cDNA sequences:

    U37028 AK097160 BQ711865 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ITGAD    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                -                                                                           
    SP2:                                                                                -                                                                           
    SP3:                          -     -                 -                                                                                                         

    ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for ITGAD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGAD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATGAGGAT
    ITGAD Expression
    About this image


    See ITGAD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGAD

    SOURCE GeneReport for Unigene cluster: Hs.679163

    UniProtKB/Swiss-Prot: ITAD_HUMAN, Q13349
    Tissue specificity: Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes
    and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on
    splenic red pulp macrophages

        SABiosciences Custom PCR Arrays for ITGAD
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGAD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGAD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGAD gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itgad1 , 5 integrin, alpha D1, 5 79.41(n)1
    73.48(a)1
      7 (70.00 cM)5
    3819241  NM_001029872.31  NP_001025043.31 
     1281543765 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    46(a)
    44(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343220.1(2388207-2422669)
    GL343220.1(2431120-2468441)
    zebrafish
    (Danio rerio)
    Actinopterygii itgam6
    si:dkey-32n7.46
    si:dkey-32n7.4
    37(a)
    34(a)
    many ↔ many
    many ↔ many
    12(4829625-4848263)
    12(4794914-4825546)
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaPS56
    scb6
    (see all 3)
    scab
    (see all 3)
    20(a)
    17(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2R(19444333-19447720)
    2R(11136290-11146003)


    ENSEMBL Gene Tree for ITGAD (if available)
    TreeFam Gene Tree for ITGAD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGAD gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  
    4 SIMAP similar genes for ITGAD using alignment to 1 protein entry:     ITAD_HUMAN:
    ITGAX    ITGAM    FLJ00114    ITGAL

    ITGAD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/908 SNPs in ITGAD are shown (see all 908)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1488744351,2
    C--31402931(+) CTCCCA/TAAGTG 1 -- us2k10--------
    rs1898517801,2
    --31403063(+) TTCCTA/GAGCTT 1 -- us2k10--------
    rs129324291,2
    C--31403145(+) aatctC/Tgactc 1 -- us2k1 tfbs36Minor allele frequency- T:0.00NA WA CSA 11
    rs1510644641,2
    C--31403275(+) TTTCAA/CCATAT 1 -- us2k10--------
    rs1814984791,2
    --31403333(+) TCAGCC/TTCTCA 1 -- us2k10--------
    rs80590291,2
    C,F--31403587(+) tggatG/Ttggtg 1 -- us2k11Minor allele frequency- T:0.12WA 118
    rs802796551,2
    C,F--31403598(+) GCTCAC/TGCCTG 1 -- us2k12Minor allele frequency- T:0.03WA 120
    rs1409701551,2
    --31403674(+) TGGGCA/GACATA 1 -- us2k10--------
    rs1501978571,2
    --31403681(+) CATAGA/TGCGAT 1 -- us2k10--------
    rs1387999841,2
    C--31403771(+) GGGAGA/GATTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGAD (31404633 - 31437826 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ITGAD:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2714194CNV Deletion23290073
    nsv833194CNV Loss17160897
    dgv2673n71CNV Loss21882294
    nsv905751CNV Loss21882294
    nsv905747CNV Gain21882294
    esv25470CNV Gain19812545


    Human Gene Mutation Database (HGMD): ITGAD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGAD
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGAD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602453    OMIM disorders: --

    4 diseases for ITGAD:    About MalaCards
    chronic monocytic leukemia    monocytic leukemia    obesity    leukemia

    1 disease from the University of Copenhagen DISEASES database for ITGAD:
    Chronic monocytic leukemia

    ITGAD for disorders           About GeneDecksing


    Export disorders for ITGAD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGAD gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with ITGAD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. (PubMed id 8666289)1, 2, 3 Wong D.A.... Springer T.A. (1996)
    2. Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb. (PubMed id 9598326)1, 3, 9 Shelley C.S....Arnaout M.A. (1998)
    3. Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3. (PubMed id 10722744)1, 2 Noti J.D.... Dillon J.D. (2000)
    4. The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1. (PubMed id 10438935)1, 2 Van der Vieren M.... Staunton D.E. (1999)
    5. Alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM- 1). (PubMed id 9841932)1, 2 Grayson M.H.... Bochner B.S. (1998)
    6. A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM- 3. (PubMed id 8777714)1, 2 Van der Vieren M.... Gallatin W.M. (1995)
    7. Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins. (PubMed id 12429998)1, 9 Noti J.D. (2002)
    8. On the potential involvement of CD11d in co-stimulati ng the production of interferon-I^ by natural killer cells upon interaction with neutrophils via intercellular adhesion molecule-3. (PubMed id 21712539)1 Costantini C....Cassatella M.A. (2011)
    9. Inflammatory phenotyping identifies CD11d as a gene m arkedly induced in white adipose tissue in obese rodents and women. (PubMed id 21508205)1 Thomas A.P....Adams S.H. (2011)
    10. The extracellular domain of CD11d regulates its cell surface expression. (PubMed id 19571252)1 McKillop W.M....Dekaban G.A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3681 HGNC: 6146 AceView: ITGAD Ensembl:ENSG00000156886 euGenes: HUgn3681
    ECgene: ITGAD Kegg: 3681 H-InvDB: ITGAD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGAD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGAD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGAD gene:
    Search GeneIP for patents involving ITGAD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ITGAD  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGAD  
     OriGene MassSpec something-or-other for ITGAD   OriGene clones in human, mouse for ITGAD  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGAD   OriGene Purified Protein for ITGAD  
     OriGene ORF clones in mouse, rat for ITGAD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGAD   OriGene Custom Protein Services for ITGAD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGAD
     QIAGEN SeqTarget long-range PCR primers for resequencing ITGAD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGAD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGAD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGAD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGAD
     GenScript Custom Purified and Recombinant Proteins Services for ITGAD GenScript cDNA clones with any tag delivered in your preferred vector for ITGAD
     GenScript Custom Assay Services for ITGAD GenScript Custom Superior Antibodies Services for ITGAD
     GenScript Custom overexpressing Cell Line Services for ITGAD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ITGAD promoter
     Search Chromatin IP Primers for ITGAD
     RT2 qPCR Primer Assay in human, mouse, rat ITGAD
     GNC Network for ITGAD
     SABiosciences PCR Arrays including human, mouse, rat ITGAD
     Search Tocris compounds for ITGAD (ITAD)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ITGAD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITGAD antibodies
     ITGAD proteins
     ITGAD lysates
     Search for Antibodies for ITGAD at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ITGAD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ITGAD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGAD
     SwitchGear 3'UTR luciferase reporter plasmids for ITGAD
     SwitchGear Promoter luciferase reporter plasmids for ITGAD
     ThermoFisher Antibodies for ITGAD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGAD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGAD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGAD
    Customized:
     lentivirus for stable overexpression of ITGAD
     lentivirus expression plasmids for stable overexpression of ITGAD
     adenovirus for overexpression of ITGAD
     Search LSBio for Antibodies for ITGAD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGAD gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4