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Aliases for ITGA9 Gene

Aliases for ITGA9 Gene

  • Integrin Subunit Alpha 9 2 3 5
  • Integrin Alpha-RLC 3 4
  • Integrin, Alpha 9 2 3
  • Integrin Alpha 9 3
  • Alpha 4-Like 2
  • Integrin 2
  • ITGA4L 3
  • RLC 3

External Ids for ITGA9 Gene

Previous GeneCards Identifiers for ITGA9 Gene

  • GC03P036794
  • GC03P037306
  • GC03P037454

Summaries for ITGA9 Gene

Entrez Gene Summary for ITGA9 Gene

  • This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA9 Gene

ITGA9 (Integrin Subunit Alpha 9) is a Protein Coding gene. Diseases associated with ITGA9 include Congenital Muscular Dystrophy With Hyperlaxity and Muir-Torre Syndrome. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. GO annotations related to this gene include collagen binding and laminin binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA9 Gene

  • Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Gene Wiki entry for ITGA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA9 Gene

Genomics for ITGA9 Gene

Regulatory Elements for ITGA9 Gene

Enhancers for ITGA9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITGA9 on UCSC Golden Path with GeneCards custom track

Promoters for ITGA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITGA9 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGA9 Gene

37,452,115 bp from pter
37,823,514 bp from pter
371,400 bases
Plus strand

Genomic View for ITGA9 Gene

Genes around ITGA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA9 Gene

Proteins for ITGA9 Gene

  • Protein details for ITGA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrin alpha-9
    Protein Accession:
    Secondary Accessions:
    • Q14638

    Protein attributes for ITGA9 Gene

    1035 amino acids
    Molecular mass:
    114489 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus).

neXtProt entry for ITGA9 Gene

Proteomics data for ITGA9 Gene at MOPED

Post-translational modifications for ITGA9 Gene

  • Glycosylation at Asn 225, Asn 476, Asn 493, Asn 612, Asn 654, Asn 658, Asn 672, Asn 676, Asn 807, Asn 854, and Asn 904
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGA9 (Integrin alpha 9)

No data available for DME Specific Peptides for ITGA9 Gene

Domains & Families for ITGA9 Gene

Gene Families for ITGA9 Gene

Suggested Antigen Peptide Sequences for ITGA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA9: view

Function for ITGA9 Gene

Molecular function for ITGA9 Gene

GENATLAS Biochemistry:
integrin,alpha 9,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,expressed in lung,small intestine and other cell lines,protein complexing with ITGB1
UniProtKB/Swiss-Prot Function:
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
UniProtKB/Swiss-Prot Induction:
Up-regulated in small cell lung cancers (SCLC).
genes like me logo Genes that share phenotypes with ITGA9: view

Animal Models for ITGA9 Gene

MGI Knock Outs for ITGA9:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGA9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA9 Gene

Localization for ITGA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ITGA9 Gene COMPARTMENTS Subcellular localization image for ITGA9 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009925 basal plasma membrane IEA --
GO:0034679 integrin alpha9-beta1 complex IEA --
genes like me logo Genes that share ontologies with ITGA9: view

Pathways & Interactions for ITGA9 Gene

genes like me logo Genes that share pathways with ITGA9: view

Gene Ontology (GO) - Biological Process for ITGA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0030593 neutrophil chemotaxis IEA --
genes like me logo Genes that share ontologies with ITGA9: view

No data available for SIGNOR curated interactions for ITGA9 Gene

Drugs & Compounds for ITGA9 Gene

(1) Drugs for ITGA9 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
RGD (Arg-Gly-Asp) Peptides Pharma Inhibits integrin binding to RGD motifs 0

(1) ApexBio Compounds for ITGA9 Gene

Compound Action Cas Number
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
genes like me logo Genes that share compounds with ITGA9: view

Transcripts for ITGA9 Gene

Unigene Clusters for ITGA9 Gene

Integrin, alpha 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA9 Gene

No ASD Table

Relevant External Links for ITGA9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITGA9 Gene

mRNA expression in normal human tissues for ITGA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA9 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for ITGA9 Gene

This gene is overexpressed in Stomach (9.3), Heart (8.8), and Fetal gut (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ITGA9 Gene

SOURCE GeneReport for Unigene cluster for ITGA9 Gene Hs.113157

mRNA Expression by UniProt/SwissProt for ITGA9 Gene

Tissue specificity: In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
genes like me logo Genes that share expression patterns with ITGA9: view

Protein tissue co-expression partners for ITGA9 Gene

- Elite partner

Primer Products

Orthologs for ITGA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITGA9 35
  • 90.18 (n)
  • 92.95 (a)
ITGA9 36
  • 92 (a)
(Canis familiaris)
Mammalia ITGA9 35
  • 91.01 (n)
  • 94.33 (a)
ITGA9 36
  • 94 (a)
(Mus musculus)
Mammalia Itga9 35
  • 85.76 (n)
  • 89.08 (a)
Itga9 16
Itga9 36
  • 90 (a)
(Pan troglodytes)
Mammalia ITGA9 35
  • 99.48 (n)
  • 99.42 (a)
ITGA9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Itga9 35
  • 85.32 (n)
  • 88.97 (a)
(Monodelphis domestica)
Mammalia ITGA9 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ITGA9 36
  • 84 (a)
(Gallus gallus)
Aves ITGA9 35
  • 77.27 (n)
  • 81.37 (a)
ITGA9 36
  • 80 (a)
(Anolis carolinensis)
Reptilia ITGA9 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itga9 35
  • 71.3 (n)
  • 75.47 (a)
(Danio rerio)
Actinopterygii itga9 35
  • 63.12 (n)
  • 61.61 (a)
zgc63474 35
itga9 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaPS4 37
  • 23 (a)
alphaPS5 37
  • 25 (a)
scb 37
  • 25 (a)
alphaPS4 36
  • 20 (a)
alphaPS5 36
  • 22 (a)
scb 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea ina-1 37
  • 25 (a)
Species with no ortholog for ITGA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA9 Gene

Gene Tree for ITGA9 (if available)
Gene Tree for ITGA9 (if available)

Paralogs for ITGA9 Gene

(6) SIMAP similar genes for ITGA9 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITGA9: view

Variants for ITGA9 Gene

Sequence variations from dbSNP and Humsavar for ITGA9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_036073 A breast cancer sample
rs267561 - 37,533,460(-) TCTCT(C/T)CTGGA reference, missense
rs149811 -- 37,515,780(+) GTTGC(C/T)TAgga intron-variant
rs149812 -- 37,518,371(+) GGCTT(C/T)ATTTT intron-variant
rs149813 -- 37,464,439(-) gtgtt(C/T)aaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA9 Gene

Variant ID Type Subtype PubMed ID
nsv876704 CNV Gain 21882294
nsv518574 CNV Gain 19592680
nsv876705 CNV Loss 21882294
nsv876706 CNV Loss 21882294
nsv522176 CNV Loss 19592680
esv24143 CNV Gain 19812545
nsv3763 CNV Insertion 18451855
esv1931472 CNV Deletion 18987734
esv1688032 CNV Deletion 17803354
esv271963 CNV Insertion 20981092
esv273307 CNV Insertion 20981092
esv2725157 CNV Deletion 23290073
nsv876707 CNV Gain 21882294
nsv508910 CNV Insertion 20534489
nsv834666 CNV Gain+Loss 17160897
esv1009667 CNV Insertion 20482838
esv1186705 CNV Insertion 17803354
esv1011375 CNV Insertion 20482838
esv28634 CNV Gain 19812545
nsv3764 CNV Insertion 18451855
nsv3765 CNV Loss 18451855
nsv527466 CNV Loss 19592680
esv2673591 CNV Deletion 23128226
esv23441 CNV Loss 19812545
dgv1447e1 CNV Complex 17122850

Variation tolerance for ITGA9 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.68; 57.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA9 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA9 Gene

Disorders for ITGA9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ITGA9 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
congenital muscular dystrophy with hyperlaxity
  • cmdh
muir-torre syndrome
  • cutaneous sebaceous neoplasms and keratoacanthomas multiple with gastrointestinal and other carcinomas
lynch syndrome
  • colorectal cancer, hereditary nonpolyposis, type 1
- elite association - COSMIC cancer census association via MalaCards
Search ITGA9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGA9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ITGA9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA9 Gene

Publications for ITGA9 Gene

  1. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. (PMID: 8245132) Palmer E.L. … Sheppard D. (J. Cell Biol. 1993) 2 3 4 23 67
  2. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. (PMID: 19686679) Bazigou E. … Makinen T. (Dev. Cell 2009) 3 23
  3. Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer. (PMID: 8290272) Hibi K. … Takahashi T. (Oncogene 1994) 2 3
  4. Association of p75(NTR) and I+9I^1 integrin modulates NGF-dependent cellular responses. (PMID: 25748048) Ventresca E.M. … Marcinkiewicz C. (Cell. Signal. 2015) 3
  5. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3

Products for ITGA9 Gene

Sources for ITGA9 Gene