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Aliases for ITGA9 Gene

Aliases for ITGA9 Gene

  • Integrin, Alpha 9 2 3
  • Integrin Alpha-RLC 3 4
  • Integrin Alpha-9 3
  • Alpha 4-Like 2
  • Integrin 2
  • ITGA4L 3
  • RLC 3

External Ids for ITGA9 Gene

Previous GeneCards Identifiers for ITGA9 Gene

  • GC03P036794
  • GC03P037306
  • GC03P037454

Summaries for ITGA9 Gene

Entrez Gene Summary for ITGA9 Gene

  • This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA9 Gene

ITGA9 (Integrin, Alpha 9) is a Protein Coding gene. Diseases associated with ITGA9 include congenital muscular dystrophy with hyperlaxity. Among its related pathways are PI3K-Akt signaling pathway and GPCR Pathway. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA9 Gene

  • Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.

Gene Wiki entry for ITGA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA9 Gene

Genomics for ITGA9 Gene

Regulatory Elements for ITGA9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGA9 Gene

37,452,115 bp from pter
37,823,514 bp from pter
371,400 bases
Plus strand

Genomic View for ITGA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA9 Gene

Proteins for ITGA9 Gene

  • Protein details for ITGA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrin alpha-9
    Protein Accession:
    Secondary Accessions:
    • Q14638

    Protein attributes for ITGA9 Gene

    1035 amino acids
    Molecular mass:
    114489 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-9 (ITGA9) associates with beta-1 (ITGB1). Integrin ITGA9:ITGB1 interacts with FBLN5 (via N-terminus).

neXtProt entry for ITGA9 Gene

Proteomics data for ITGA9 Gene at MOPED

Post-translational modifications for ITGA9 Gene

  • Glycosylation at Asn225, Asn476, Asn493, Asn612, Asn654, Asn658, Asn672, Asn676, Asn807, Asn854, and Asn904
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGA9 (Integrin alpha 9)

No data available for DME Specific Peptides for ITGA9 Gene

Domains for ITGA9 Gene

Gene Families for ITGA9 Gene

Suggested Antigen Peptide Sequences for ITGA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA9: view

Function for ITGA9 Gene

Molecular function for ITGA9 Gene

GENATLAS Biochemistry:
integrin,alpha 9,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,expressed in lung,small intestine and other cell lines,protein complexing with ITGB1
UniProtKB/Swiss-Prot Function:
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin.
UniProtKB/Swiss-Prot Induction:
Up-regulated in small cell lung cancers (SCLC).

Gene Ontology (GO) - Molecular Function for ITGA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005518 collagen binding IEA --
GO:0043236 laminin binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGA9: view
genes like me logo Genes that share phenotypes with ITGA9: view

Animal Models for ITGA9 Gene

MGI Knock Outs for ITGA9:

Animal Model Products

miRNA for ITGA9 Gene

miRTarBase miRNAs that target ITGA9

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA9

Clone Products

  • Addgene plasmids for ITGA9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGA9 Gene

Localization for ITGA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA9 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ITGA9 Gene COMPARTMENTS Subcellular localization image for ITGA9 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex TAS 8245132
GO:0009925 basal plasma membrane IEA --
GO:0016020 membrane --
GO:0034679 integrin alpha9-beta1 complex IEA --
genes like me logo Genes that share ontologies with ITGA9: view

Pathways for ITGA9 Gene

genes like me logo Genes that share pathways with ITGA9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ITGA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IGI 21060781
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007411 axon guidance TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030593 neutrophil chemotaxis IEA --
genes like me logo Genes that share ontologies with ITGA9: view

Drugs for ITGA9 Gene

(1) ApexBio Compounds for ITGA9 Gene

Compound Action Cas Number
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs [99896-85-2]
genes like me logo Genes that share compounds with ITGA9: view

Transcripts for ITGA9 Gene

mRNA/cDNA for ITGA9 Gene

Unigene Clusters for ITGA9 Gene

Integrin, alpha 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA9

Clone Products

  • Addgene plasmids for ITGA9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA9 Gene

No ASD Table

Relevant External Links for ITGA9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITGA9 Gene

mRNA expression in normal human tissues for ITGA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA9 Gene

This gene is overexpressed in Artery - Aorta (4.1).

Protein differential expression in normal tissues for ITGA9 Gene

This gene is overexpressed in Stomach (9.3), Heart (8.8), and Fetal gut (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGA9 Gene

SOURCE GeneReport for Unigene cluster for ITGA9 Gene Hs.113157

mRNA Expression by UniProt/SwissProt for ITGA9 Gene

Tissue specificity: In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
genes like me logo Genes that share expressions with ITGA9: view

Expression partners for ITGA9 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for ITGA9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITGA9 35
  • 90.18 (n)
  • 92.95 (a)
ITGA9 36
  • 92 (a)
(Canis familiaris)
Mammalia ITGA9 35
  • 91.01 (n)
  • 94.33 (a)
ITGA9 36
  • 94 (a)
(Mus musculus)
Mammalia Itga9 35
  • 85.76 (n)
  • 89.08 (a)
Itga9 16
Itga9 36
  • 90 (a)
(Pan troglodytes)
Mammalia ITGA9 35
  • 99.48 (n)
  • 99.42 (a)
ITGA9 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Itga9 35
  • 85.32 (n)
  • 88.97 (a)
(Monodelphis domestica)
Mammalia ITGA9 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ITGA9 36
  • 84 (a)
(Gallus gallus)
Aves ITGA9 35
  • 77.27 (n)
  • 81.37 (a)
ITGA9 36
  • 80 (a)
(Anolis carolinensis)
Reptilia ITGA9 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itga9 35
  • 71.3 (n)
  • 75.47 (a)
(Danio rerio)
Actinopterygii itga9 35
  • 63.12 (n)
  • 61.61 (a)
zgc63474 35
itga9 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaPS4 37
  • 23 (a)
alphaPS5 37
  • 25 (a)
scb 37
  • 25 (a)
alphaPS4 36
  • 20 (a)
alphaPS5 36
  • 22 (a)
scb 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea ina-1 37
  • 25 (a)
Species with no ortholog for ITGA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA9 Gene

Gene Tree for ITGA9 (if available)
Gene Tree for ITGA9 (if available)

Paralogs for ITGA9 Gene

(6) SIMAP similar genes for ITGA9 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITGA9: view

Variants for ITGA9 Gene

Sequence variations from dbSNP and Humsavar for ITGA9 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs149811 -- 37,515,780(+) GTTGC(C/T)TAgga intron-variant
rs149812 -- 37,518,371(+) GGCTT(C/T)ATTTT intron-variant
rs149813 -- 37,464,439(-) gtgtt(C/T)aaaga intron-variant
rs149814 -- 37,464,879(-) CCTCT(A/G)ACCAC intron-variant
rs149815 -- 37,467,060(-) GAGTG(A/G)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA9 Gene

Variant ID Type Subtype PubMed ID
nsv876704 CNV Gain 21882294
nsv518574 CNV Gain 19592680
nsv876705 CNV Loss 21882294
nsv876706 CNV Loss 21882294
nsv522176 CNV Loss 19592680
esv24143 CNV Gain 19812545
nsv3763 CNV Insertion 18451855
esv1931472 CNV Deletion 18987734
esv1688032 CNV Deletion 17803354
esv271963 CNV Insertion 20981092
esv273307 CNV Insertion 20981092
esv2725157 CNV Deletion 23290073
nsv876707 CNV Gain 21882294
nsv508910 CNV Insertion 20534489
nsv834666 CNV Gain+Loss 17160897
esv1009667 CNV Insertion 20482838
esv1186705 CNV Insertion 17803354
esv1011375 CNV Insertion 20482838
esv28634 CNV Gain 19812545
nsv3764 CNV Insertion 18451855
nsv3765 CNV Loss 18451855
nsv527466 CNV Loss 19592680
esv2673591 CNV Deletion 23128226
esv23441 CNV Loss 19812545
dgv1447e1 CNV Complex 17122850

Relevant External Links for ITGA9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA9 Gene

Disorders for ITGA9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ITGA9 Gene in MalaCards »

(1) Disease for ITGA9 Gene

(1) University of Copenhagen DISEASES for ITGA9 Gene

Relevant External Links for ITGA9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ITGA9: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ITGA9 Gene

Publications for ITGA9 Gene

  1. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. (PMID: 8245132) Palmer E.L. … Sheppard D. (J. Cell Biol. 1993) 2 3 4 23
  2. Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer. (PMID: 8290272) Hibi K. … Takahashi T. (Oncogene 1994) 2 3 4
  3. A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. (PMID: 18973153) Ma G.C. … Chen M. (Prenat. Diagn. 2008) 3 48
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48
  5. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PMID: 20479155) Takeuchi F. … Kato N. (Circulation 2010) 3 48

Products for ITGA9 Gene

  • Addgene plasmids for ITGA9

Sources for ITGA9 Gene

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