Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA9 Gene

protein-coding   GIFtS: 65
GCID: GC03P037468

Integrin, Alpha 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 91 2     ALPHA-RLC2
Integrin Alpha-RLC2 3     ITGA4L2
Alpha 4-Like1     RLC2
integrin1     Integrin Alpha-92

External Ids:    HGNC: 61451   Entrez Gene: 36802   Ensembl: ENSG000001446687   OMIM: 6039635   UniProtKB: Q137973   

Export aliases for ITGA9 gene to outside databases

Previous GC identifers: GC03P036794 GC03P037306 GC03P037454


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA9 Gene:
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an
alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene,
when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin.
Expression of this gene has been found to be upregulated in small cell lung cancers. (provided by RefSeq, Jul
2008)

GeneCards Summary for ITGA9 Gene: 
ITGA9 (integrin, alpha 9) is a protein-coding gene. Diseases associated with ITGA9 include lynch syndrome, and lung cancer, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797
Function: Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence
A-E-I-D-G-I-E-L in cytotactin

Gene Wiki entry for ITGA9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA9 gene promoter:
         HTF   NRSF form 1   NRSF form 2   HNF-1A   CREB   FOXO4   deltaCREB   HNF-1   ZID   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ITGA9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

ITGA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P037468:  view genomic region     (about GC identifiers)

Start:
37,493,606 bp from pter      End:
37,865,005 bp from pter
Size:
371,400 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797 (See protein sequence)
Recommended Name: Integrin alpha-9 precursor  
Size: 1035 amino acids; 114489 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q14638

Explore the universe of human proteins at neXtProt for ITGA9: NX_Q13797

Explore proteomics data for ITGA9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13797

  • ITGA9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA9 Protein Expression
    REFSEQ proteins: NP_002198.2  
    ENSEMBL proteins: 
     ENSP00000397258   ENSP00000264741   ENSP00000406533  
    Reactome Protein details: Q13797
    Human Recombinant Protein Products for ITGA9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA9 (Integrin alpha 9 beta 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA9
    OriGene Protein Over-expression Lysate for ITGA9
    OriGene MassSpec for ITGA9 
    OriGene Custom Protein Services for ITGA9
    GenScript Custom Purified and Recombinant Proteins Services for ITGA9
    Novus Biologicals ITGA9 Protein
    Novus Biologicals ITGA9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009925basal plasma membrane IEA--

    ITGA9 for ontologies           About GeneDecksing



    ITGA9 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA9
    R&D Systems Antibodies for ITGA9 (Integrin alpha 9)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITGA9
    GenScript Custom Superior Antibodies Services for ITGA9
    Novus Biologicals ITGA9 Antibodies
    Abcam antibodies for ITGA9
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ITGA9
    LSBio Antibodies in human, mouse, rat for ITGA9 

    Assay Products for ITGA9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA9
    R&D Systems Proteome Profiler Antibody Arrays for ITGA9 (Integrin alpha 9)
    GenScript Custom Assay Services for ITGA9
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry Q13797

    ProtoNet protein and cluster: Q13797

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGA9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA9_HUMAN, Q13797
    Function: Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence
    A-E-I-D-G-I-E-L in cytotactin
    Induction: Up-regulated in small cell lung cancers (SCLC)

         Genatlas biochemistry entry for ITGA9:
    integrin,alpha 9,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,expressed in lung,small intestine and other cell lines,protein complexing with ITGB1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ITGA9 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Itga9):
     cardiovascular system  growth/size  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  normal  respiratory system  vision/eye 

    ITGA9 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGA9: Itga9tm1(KOMP)Vlcg Itga9tm1Des

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA9 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA9:
    hsa-mir-194 (MIRT005895)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA9
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA9 (see all 18):
    hsa-miR-194* hsa-miR-520f hsa-miR-125a-5p hsa-miR-148b hsa-miR-137 hsa-miR-331-3p hsa-miR-340 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidITGA9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA9
    Sirion Biotech Customized adenovirus for overexpression of ITGA9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGA9 (see all 8)
    OriGene ORF clones in mouse, rat for ITGA9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA9 (NM_002207)
    Sino Biological Human cDNA Clone for ITGA9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA9
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA9 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA9
    Search LifeMap BioReagents cell lines for ITGA9
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA9 About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    ECM proteoglycans0.38
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA9 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGA9
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    5/8        Reactome Pathways for ITGA9 (see all 8)
        Signal transduction by L1
    ECM proteoglycans
    L1CAM interactions
    Extracellular matrix organization
    Developmental Biology


    5/8         Kegg Pathways  (Kegg details for ITGA9) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Regulation of actin cytoskeleton


    ITGA9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITGA9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for ITGA9 (Q137973 ENSP000002647414) via UniProtKB, MINT, STRING, and/or I2D (see all 108)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIGFO439153, ENSP000002979044I2D: score=1 STRING: ENSP00000297904
    ITGB7P260103, ENSP000002670824I2D: score=1 STRING: ENSP00000267082
    SAT1P216733, ENSP000003685724I2D: score=1 STRING: ENSP00000368572
    SPP1P104513, ENSP000003785174I2D: score=1 STRING: ENSP00000378517
    ITGB1P055563, ENSP000003640944I2D: score=3 STRING: ENSP00000364094
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IGI--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007411axon guidance TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030593neutrophil chemotaxis IEA--

    ITGA9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGA9 (ITA9)

    Search CenterWatch for drugs/clinical trials and news about ITGA9 / ITA9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA9 gene: 
    NM_002207.2  

    Unigene Cluster for ITGA9:

    Integrin, alpha 9
    Hs.113157  [show with all ESTs]
    Unigene Representative Sequence: BX647350
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422441(uc003chc.3) ENST00000264741(uc003chd.3) ENST00000461533
    ENST00000411817
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA9
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA9 (see all 18):
    hsa-miR-194* hsa-miR-520f hsa-miR-125a-5p hsa-miR-148b hsa-miR-137 hsa-miR-331-3p hsa-miR-340 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidITGA9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA9
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA9 (see all 8)
    OriGene ORF clones in mouse, rat for ITGA9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA9 (NM_002207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA9
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA9 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA9 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGA9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA9

    Additional mRNA sequence: 

    AK026826.1 AK123884.1 BC030198.1 BX647350.1 D25303.1 L24158.1 

    4 DOTS entries:

    DT.112847  DT.410451  DT.120860776  DT.99929251 

    24/97 AceView cDNA sequences (see all 97):

    BQ574863 AI084810 BX478742 BF968873 AA922648 F11449 Z45898 NM_002207 
    AA613179 BM670533 BM700418 L24158 AA039686 BC030198 CD243463 AK026826 
    AI094384 CD692166 BM972331 AI279388 AA039668 F09111 AI143386 BQ003513 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA9 expression in normal human tissues (normalized intensities)      ITGA9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGAATAA
    ITGA9 Expression
    About this image


    ITGA9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             S-shaped Body
             visceral organ/metanephros/nephrogenic zone   
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    See ITGA9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA9

    SOURCE GeneReport for Unigene cluster: Hs.113157

    UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797
    Tissue specificity: In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle,
    skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers

        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA9: 
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGA9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGA9 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga91 , 5 integrin alpha 91, 5 86.44(n)1
    90.05(a)1
      9 (70.32 cM)5
    1040991  NM_133721.21  NP_598482.21 
     1186066905 
    chicken
    (Gallus gallus)
    Aves ITGA91 integrin, alpha 9 76.78(n)
    80.45(a)
      420757  NM_001012858.1  NP_001012876.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA96
    integrin, alpha 9
    78(a)
    1 ↔ 1
    6(44033690-44406588)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc634742 similar to integrin alpha 9 74.45(n)   394012  BC054897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaPS53 cell-matrix adhesion cell adhesion
    receptor
    25(a)
    (best of 3)
      59E4   --


    ENSEMBL Gene Tree for ITGA9 (if available)
    TreeFam Gene Tree for ITGA9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA9 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA102  
    ITGA42  
    6 SIMAP similar genes for ITGA9 using alignment to 4 protein entries:     ITA9_HUMAN (see all proteins):
    ITGA4    IA4    ITGA3    ITGA5    ITGA2B    ITGA7

    ITGA9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7713 SNPs in ITGA9 are shown (see all 7713)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360734
    A breast cancer sample4--see VAR_0360732 R C mis40--------
    rs1823379801,2
    --37423977(+) GCTAAG/TTTTTT 1 -- us2k10--------
    rs1433872651,2
    C--37424120(+) TCTTT-/CAACAA 1 -- us2k10--------
    rs1451535561,2
    --37424139(+) CATCTA/GCCTAA 1 -- us2k10--------
    rs1866463481,2
    --37424157(+) ACTGAG/TCTGGG 1 -- us2k10--------
    rs1925168541,2
    --37424158(+) CTGAGC/GTGGGC 1 -- us2k10--------
    rs1389766611,2
    --37424273(+) TGAGAC/TAGAGG 1 -- us2k10--------
    rs1840105461,2
    --37424279(+) AGAGGA/CATGTG 1 -- us2k10--------
    rs1421381251,2
    --37424496(+) TGTGTA/GTGGAT 1 -- us2k10--------
    rs1885037751,2
    --37424598(+) GAGATC/TGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGA9 (37493606 - 37743606 bp, first 250kb of ITGA9)

    Structural Variations
         Database of Genomic Variants (DGV) 10/25 variations for ITGA9 (see all 25):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725157CNV Deletion23290073
    esv1688032CNV Deletion17803354
    esv1931472CNV Deletion18987734
    esv2673591CNV Deletion23128226
    esv1011375CNV Insertion20482838
    nsv3763CNV Insertion18451855
    esv1009667CNV Insertion20482838
    esv1186705CNV Insertion17803354
    nsv3764CNV Insertion18451855
    esv273307CNV Insertion20981092


    Human Gene Mutation Database (HGMD): ITGA9
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA9
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603963    OMIM disorders: --

    16 diseases for ITGA9:    About MalaCards
    lynch syndrome    lung cancer    lymphedema    pandas
    hypertrophic cardiomyopathy    medulloblastoma    essential hypertension    rhabdomyosarcoma
    dilated cardiomyopathy    nasopharyngitis    hypertension    arthritis
    colorectal cancer    melanoma    endotheliitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ITGA9:
    Lymphedema

    ITGA9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ITGA9
    Human Genome Epidemiology (HuGE) Navigator: ITGA9 (6 documents)

    Export disorders for ITGA9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA9 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with ITGA9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. (PubMed id 8245132)1, 2, 3, 9 Palmer E.L.... Sheppard D. (1993)
    2. Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer. (PubMed id 8290272)1, 2, 3 Hibi K.... Takahashi T. (1994)
    3. Genome-wide association study identifies novel loci as sociated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (2012)
    4. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PubMed id 20414254)1, 4 Hong K.W....Oh B. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (2010)
    7. A genome-wide association study identifies ITGA9 conf erring risk of nasopharyngeal carcinoma. (PubMed id 19478819)1, 4 Ng C.C....Mushiroda T. (2009)
    8. A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. (PubMed id 18973153)1, 4 Ma G.C....Chen M. (2008)
    9. Integrin-alpha9 is required for fibronectin matrix as sembly during lymphatic valve morphogenesis. (PubMed id 19686679)1, 9 Bazigou E....Makinen T. (2009)
    10. Integrin a9b1 promotes malignant tumor growth and meta stasis by potentiating epithelial-mesenchymal transition. (PubMed id 22370635)1 Gupta S.K....Vlahakis N.E. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3680 HGNC: 6145 AceView: ITGA9 Ensembl:ENSG00000144668 euGenes: HUgn3680
    ECgene: ITGA9 Kegg: 3680 H-InvDB: ITGA9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA9 gene:
    Search GeneIP for patents involving ITGA9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA9
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ITGA9 (Integrin alpha 9)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ITGA9 (Integrin alpha 9 beta 1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ITGA9 (Integrin alpha 9)  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ITGA9  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGA9  
     OriGene MassSpec something-or-other for ITGA9   OriGene clones in human, mouse for ITGA9  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGA9   OriGene Purified Protein for ITGA9  
     OriGene ORF clones in mouse, rat for ITGA9   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGA9   OriGene Custom Protein Services for ITGA9  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGA9
     QIAGEN SeqTarget long-range PCR primers for resequencing ITGA9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA9
     GenScript Custom Purified and Recombinant Proteins Services for ITGA9 GenScript cDNA clones with any tag delivered in your preferred vector for ITGA9
     GenScript Custom Assay Services for ITGA9 GenScript Custom Superior Antibodies Services for ITGA9
     GenScript Custom overexpressing Cell Line Services for ITGA9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ITGA9 promoter
     Search Chromatin IP Primers for ITGA9
     RT2 qPCR Primer Assay in human, mouse, rat ITGA9
     Search GNC Networks for ITGA9
     SABiosciences PCR Arrays including human, mouse, rat ITGA9
     Search Tocris compounds for ITGA9 (ITA9)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ITGA9
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITGA9 antibodies
     ITGA9 proteins
     ITGA9 lysates
     Antibodies for ITGA9
     See all of Abcam's Antibodies, Kits and Proteins for ITGA9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ITGA9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA9
     SwitchGear 3'UTR luciferase reporter plasmids for ITGA9
     Browse SwitchGear Promoter luciferase reporter plasmids for ITGA9
     ThermoFisher Antibodies for ITGA9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA9
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA9
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA9
    Customized:
     lentivirus for stable overexpression of ITGA9
     lentivirus expression plasmids for stable overexpression of ITGA9
     adenovirus for overexpression of ITGA9
     LSBio Antibodies in human, mouse, rat for ITGA9
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGA9 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4