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ITGA9 Gene

protein-coding   GIFtS: 65
GCID: GC03P037468

Integrin, Alpha 9

  See ITGA9-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 91 2     ALPHA-RLC2
Integrin Alpha-RLC2 3     ITGA4L2
Alpha 4-Like1     RLC2
integrin1     Integrin Alpha-92

External Ids:    HGNC: 61451   Entrez Gene: 36802   Ensembl: ENSG000001446687   OMIM: 6039635   UniProtKB: Q137973   

Export aliases for ITGA9 gene to outside databases

Previous GC identifers: GC03P036794 GC03P037306 GC03P037454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA9 Gene:
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an
alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene,
when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin.
Expression of this gene has been found to be upregulated in small cell lung cancers. (provided by RefSeq, Jul
2008)

GeneCards Summary for ITGA9 Gene:
ITGA9 (integrin, alpha 9) is a protein-coding gene. Diseases associated with ITGA9 include congenital muscular dystrophy with hyperlaxity. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797
Function: Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence
A-E-I-D-G-I-E-L in cytotactin

Gene Wiki entry for ITGA9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA9 gene promoter:
         HTF   NRSF form 1   NRSF form 2   HNF-1A   CREB   FOXO4   deltaCREB   HNF-1   ZID   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ITGA9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p21.3

ITGA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA9 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P037468:  view genomic region     (about GC identifiers)

Start:
37,493,606 bp from pter      End:
37,865,005 bp from pter
Size:
371,400 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797 (See protein sequence)
Recommended Name: Integrin alpha-9 precursor  
Size: 1035 amino acids; 114489 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1
Secondary accessions: Q14638

Explore the universe of human proteins at neXtProt for ITGA9: NX_Q13797

Explore proteomics data for ITGA9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn225, Asn476, Asn493, Asn612, Asn654, Asn658, Asn672, Asn676, Asn807, Asn854,
                                 Asn904
  • Modification sites at PhosphoSitePlus

  • See ITGA9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002198.2  
    ENSEMBL proteins: 
     ENSP00000397258   ENSP00000264741   ENSP00000406533  
    Reactome Protein details: Q13797

    ITGA9 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA9 (Integrin alpha 9 beta 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA9
    OriGene Protein Over-expression Lysate for ITGA9
    OriGene MassSpec for ITGA9
    OriGene Custom Protein Services for ITGA9
    GenScript Custom Purified and Recombinant Proteins Services for ITGA9
    Novus Biologicals ITGA9 Protein
    Novus Biologicals ITGA9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA9 

    ITGA9 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA9
    R&D Systems Antibodies for ITGA9 (Integrin alpha 9)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITGA9
    Novus Biologicals ITGA9 Antibodies
    Abcam antibodies for ITGA9 (P05556, Q13797)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ITGA9
    LSBio Antibodies in human, mouse, rat for ITGA9

    ITGA9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGA9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry Q13797

    ProtoNet protein and cluster: Q13797

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    Find genes that share domains with ITGA9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA9_HUMAN, Q13797
    Function: Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence
    A-E-I-D-G-I-E-L in cytotactin
    Induction: Up-regulated in small cell lung cancers (SCLC)

         Genatlas biochemistry entry for ITGA9:
    integrin,alpha 9,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,expressed in lung,small intestine and other cell lines,protein complexing with ITGB1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005518collagen binding IEA--
    GO:0043236laminin binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGA9           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itga9):
     cardiovascular system  growth/size/body  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  normal  respiratory system  vision/eye 

    Find genes that share phenotypes with ITGA9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ITGA9: Itga9tm1(KOMP)Vlcg Itga9tm1Des

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA9

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA9:
    hsa-mir-484 (MIRT041874), hsa-mir-194-5p (MIRT005895)

    Block miRNA regulation of human, mouse, rat ITGA9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA9 (see all 18):
    hsa-miR-194* hsa-miR-520f hsa-miR-125a-5p hsa-miR-148b hsa-miR-137 hsa-miR-331-3p hsa-miR-340 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidITGA9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA9
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA9

    Clone
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    OriGene clones in human, mouse for ITGA9 (see all 8)
    OriGene ORF clones in mouse, rat for ITGA9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA9 (NM_002207)
    Sino Biological Human cDNA Clone for ITGA9
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA9
    Addgene plasmids for ITGA9 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA9_HUMAN, Q13797: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS8245132
    GO:0009925basal plasma membrane IEA--
    GO:0016020membrane ----
    GO:0034679alpha9-beta1 integrin complex IEA--

    Find genes that share ontologies with ITGA9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA9 About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with ITGA9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA9 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 BioSystems Pathways for ITGA9
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    3 Reactome Pathways for ITGA9
        ECM proteoglycans
    Signal transduction by L1
    Integrin cell surface interactions


    Selected Kegg Pathways  (Kegg details for ITGA9) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA9: 
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ITGA9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA9 (Q137973 ENSP000002647414) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FIGFO439153, ENSP000002979044I2D: score=1 STRING: ENSP00000297904
    ITGB7P260103, ENSP000002670824I2D: score=1 STRING: ENSP00000267082
    SAT1P216733, ENSP000003685724I2D: score=1 STRING: ENSP00000368572
    SPP1P104513, ENSP000003785174I2D: score=1 STRING: ENSP00000378517
    ITGB1P055563, ENSP000003640944I2D: score=3 STRING: ENSP00000364094
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IGI--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007411axon guidance TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030593neutrophil chemotaxis IEA--

    Find genes that share ontologies with ITGA9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGA9 (ITA9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGA9 gene: 
    NM_002207.2  

    Unigene Cluster for ITGA9:

    Integrin, alpha 9
    Hs.113157  [show with all ESTs]
    Unigene Representative Sequence: BX647350
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000422441(uc003chc.3) ENST00000264741(uc003chd.3) ENST00000461533
    ENST00000411817
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA9 (see all 18):
    hsa-miR-194* hsa-miR-520f hsa-miR-125a-5p hsa-miR-148b hsa-miR-137 hsa-miR-331-3p hsa-miR-340 hsa-miR-125b
    SwitchGear 3'UTR luciferase reporter plasmidITGA9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGA9
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA9
    Clone
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    GenScript: all cDNA clones in your preferred vector: ITGA9 (NM_002207)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA9
    Addgene plasmids for ITGA9 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA9
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA9
      QuantiFast Probe-based Assays in human, mouse, rat ITGA9

    Additional mRNA sequence: 

    AK026826.1 AK123884.1 BC030198.1 BX647350.1 D25303.1 L24158.1 

    4 DOTS entries:

    DT.112847  DT.410451  DT.120860776  DT.99929251 

    Selected AceView cDNA sequences (see all 97):

    BM700418 AA039668 BM670533 BQ574863 NM_002207 F11449 BF968873 AI094384 
    CD692166 BM972331 AA613179 CD243463 AA039686 AA922648 BX478742 L24158 
    AI949812 AI143386 AI084810 F09111 Z45898 AI279388 BC030198 AK026826 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGAATAA
    ITGA9 Expression
    About this image


    ITGA9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
             Limbal corneal epithelial stem cells
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hindlimb Dorsal Muscle
    ITGA9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113157

    UniProtKB/Swiss-Prot: ITA9_HUMAN, Q13797
    Tissue specificity: In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle,
    skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA9: 
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA9
    QuantiTect SYBR Green Assays in human, mouse, rat ITGA9
    QuantiFast Probe-based Assays in human, mouse, rat ITGA9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ITGA9 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga91 , 5 integrin alpha 91, 5 85.76(n)1
    89.08(a)1
      9 (70.32 cM)5
    1040991  NM_133721.21  NP_598482.21 
     1186066905 
    chicken
    (Gallus gallus)
    Aves ITGA91 integrin, alpha 9 77.27(n)
    81.37(a)
      420757  NM_001012858.1  NP_001012876.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA96
    integrin, alpha 9
    78(a)
    1 ↔ 1
    6(44033690-44406588)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itga91 integrin, alpha 9 71.3(n)
    75.47(a)
      100494771  XM_004915354.1  XP_004915411.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc634742 similar to integrin alpha 9 74.45(n)   394012  BC054897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaPS53 cell-matrix adhesion cell adhesion
    receptor
    25(a)
    (best of 3)
      59E4   --


    ENSEMBL Gene Tree for ITGA9 (if available)
    TreeFam Gene Tree for ITGA9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA9 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA42  
    ITGA102  
    6 SIMAP similar genes for ITGA9 using alignment to 4 protein entries:     ITA9_HUMAN (see all proteins):
    ITGA4    IA4    ITGA3    ITGA5    ITGA2B    ITGA7

    Find genes that share paralogs with ITGA9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA9 (see all 7713)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0360734
    A breast cancer sample4--see VAR_0360732 R C mis40--------
    rs1823379801,2
    --37423977(+) GCTAAG/TTTTTT 1 -- us2k10--------
    rs1433872651,2
    C--37424120(+) TCTTT-/CAACAA 1 -- us2k10--------
    rs1451535561,2
    --37424139(+) CATCTA/GCCTAA 1 -- us2k10--------
    rs1866463481,2
    --37424157(+) ACTGAG/TCTGGG 1 -- us2k10--------
    rs1925168541,2
    --37424158(+) CTGAGC/GTGGGC 1 -- us2k10--------
    rs1389766611,2
    --37424273(+) TGAGAC/TAGAGG 1 -- us2k10--------
    rs1840105461,2
    --37424279(+) AGAGGA/CATGTG 1 -- us2k10--------
    rs1421381251,2
    --37424496(+) TGTGTA/GTGGAT 1 -- us2k10--------
    rs1885037751,2
    --37424598(+) GAGATC/TGGGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGA9 (37493606 - 37743606 bp, first 250kb of ITGA9)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGA9 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725157CNV Deletion23290073
    esv1688032CNV Deletion17803354
    esv1931472CNV Deletion18987734
    esv2673591CNV Deletion23128226
    esv1011375CNV Insertion20482838
    nsv3763CNV Insertion18451855
    esv1009667CNV Insertion20482838
    esv1186705CNV Insertion17803354
    nsv3764CNV Insertion18451855
    esv273307CNV Insertion20981092

    Human Gene Mutation Database (HGMD): ITGA9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA9
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603963    OMIM disorders: --

    1 disease for ITGA9:    
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    congenital muscular dystrophy with hyperlaxity

    1 disease from the University of Copenhagen DISEASES database for ITGA9:
    Lymphedema

    Find genes that share disorders with ITGA9           About GenesLikeMe

    Genetic Association Database (GAD): ITGA9
    Human Genome Epidemiology (HuGE) Navigator: ITGA9 (6 documents)

    Export disorders for ITGA9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA9 gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with ITGA9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. (PubMed id 8245132)1, 2, 3, 9 Palmer E.L.... Sheppard D. (J. Cell Biol. 1993)
    2. Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancer. (PubMed id 8290272)1, 2, 3 Hibi K.... Takahashi T. (Oncogene 1994)
    3. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PubMed id 22359512)1, 4 Demirkan A....Schmitz G. (PLoS Genet. 2012)
    4. Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population. (PubMed id 20414254)1, 4 Hong K.W....Oh B. (J. Hum. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Blood pressure and hypertension are associated with 7 loci in the Japanese population. (PubMed id 20479155)1, 4 Takeuchi F....Kato N. (Circulation 2010)
    7. A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. (PubMed id 19478819)1, 4 Ng C.C....Mushiroda T. (J. Hum. Genet. 2009)
    8. A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy. (PubMed id 18973153)1, 4 Ma G.C....Chen M. (Prenat. Diagn. 2008)
    9. Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. (PubMed id 19686679)1, 9 Bazigou E....Makinen T. (Dev. Cell 2009)
    10. Integrin I+9I^1 promotes malignant tumor growth and metastasis by potentiating epithelial-mesenchymal transition. (PubMed id 22370635)1 Gupta S.K....Vlahakis N.E. (Oncogene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3680 HGNC: 6145 AceView: ITGA9 Ensembl:ENSG00000144668 euGenes: HUgn3680
    ECgene: ITGA9 Kegg: 3680 H-InvDB: ITGA9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGA9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGA9 gene:
    Search GeneIP for patents involving ITGA9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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