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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA8 Gene

protein-coding   GIFtS: 63
GCID: GC10M015599

Integrin, Alpha 8

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 81 2
Integrin Alpha-82

External Ids:    HGNC: 61441   Entrez Gene: 85162   Ensembl: ENSG000000779437   OMIM: 6040635   UniProtKB: P537083   

Export aliases for ITGA8 gene to outside databases

Previous GC identifers: GC10M015541 GC10M015709 GC10M015563


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ITGA8 Gene: 
ITGA8 (integrin, alpha 8) is a protein-coding gene. Diseases associated with ITGA8 include keratopathy, and bullous keratopathy, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708
Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating
the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array
of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney
genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory
and motor neurons

Gene Wiki entry for ITGA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008705.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA8 gene promoter:
         GR   RP58   ATF-2   FOXD1   CRE-BP1   MEF-2A   AREB6   c-Myb   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA8 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

ITGA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M015599:  view genomic region     (about GC identifiers)

Start:
15,555,948 bp from pter      End:
15,762,124 bp from pter
Size:
206,177 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708 (See protein sequence)
Recommended Name: Integrin alpha-8 precursor  
Size: 1063 amino acids; 117474 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-8 associates with beta-1
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: B0YJ31 Q5VX94

Explore the universe of human proteins at neXtProt for ITGA8: NX_P53708

Explore proteomics data for ITGA8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53708

  • ITGA8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA8 Protein Expression
    REFSEQ proteins: NP_003629.1  
    ENSEMBL proteins: 
     ENSP00000367316  
    Reactome Protein details: P53708
    Human Recombinant Protein Products for ITGA8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA8
    OriGene Protein Over-expression Lysate for ITGA8
    OriGene MassSpec for ITGA8 
    OriGene Custom Protein Services for ITGA8
    GenScript Custom Purified and Recombinant Proteins Services for ITGA8
    Novus Biologicals ITGA8 Protein
    Novus Biologicals ITGA8 Lysate
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for ITGA8 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS7768999
    GO:0034678alpha8-beta1 integrin complex TAS--
    GO:0045177apical part of cell IEA--

    ITGA8 for ontologies           About GeneDecksing



    ITGA8 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA8
    R&D Systems Antibodies for ITGA8 (Integrin alpha 8)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITGA8
    GenScript Custom Superior Antibodies Services for ITGA8
    Novus Biologicals ITGA8 Antibodies
    Abcam antibodies for ITGA8
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for ITGA8
    LSBio Antibodies in human, mouse, rat for ITGA8 

    Assay Products for ITGA8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGA8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P53708

    ProtoNet protein and cluster: P53708

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGA8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA8_HUMAN, P53708
    Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating
    the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array
    of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney
    genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory
    and motor neurons

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    ITGA8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGA8:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itga8):
     behavior/neurological  cellular  hearing/vestibular/ear  mortality/aging  nervous system 
     renal/urinary system  respiratory system 

    ITGA8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itga8tm1Lfr for ITGA8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGA8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA8

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ITGA8
    Sirion Biotech Customized adenovirus for overexpression of ITGA8

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGA8 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA8 (NM_003638)
    Sino Biological Human cDNA Clone for ITGA8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA8
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA8 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA8 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA8 About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    ECM proteoglycans0.38
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ITGA8
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion PLAU signaling

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA8 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 GeneGo (Thomson Reuters) Pathways for ITGA8
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion PLAU signaling

    3 BioSystems Pathways for ITGA8
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    5/6        Reactome Pathways for ITGA8 (see all 6)
        ECM proteoglycans
    Molecules associated with elastic fibres
    Extracellular matrix organization
    Integrin cell surface interactions
    Elastic fibre formation


    5/8         Kegg Pathways  (Kegg details for ITGA8) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Regulation of actin cytoskeleton


    ITGA8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/106 Interacting proteins for ITGA8 (P537083 ENSP000003673164) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=1 STRING: ENSP00000346839
    ITGB1P055563, ENSP000003640944I2D: score=4 STRING: ENSP00000364094
    ITGA3P260063, ENSP000000077224I2D: score=1 STRING: ENSP00000007722
    NPNTQ6UXI93, ENSP000003693234I2D: score=2 STRING: ENSP00000369323
    VTNP040043, ENSP000002262184I2D: score=1 STRING: ENSP00000226218
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0007160cell-matrix adhesion NAS7768999
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007399nervous system development IEA--
    GO:0007613memory IEA--

    ITGA8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGA8 (ITA8)

    Search CenterWatch for drugs/clinical trials and news about ITGA8 / ITA8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA8 gene: 
    NM_003638.1  

    Unigene Cluster for ITGA8:

    Integrin, alpha 8
    Hs.171311  [show with all ESTs]
    Unigene Representative Sequence: NM_003638
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378076(uc001ioc.1 uc010qcb.1) ENST00000477064 ENST00000468882


    miRNA
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGA8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA8
    Clone
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    GenScript: all cDNA clones in your preferred vector: ITGA8 (NM_003638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA8
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                         Customized lentivirus expression plasmids for stable overexpression of ITGA8 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA8

    Additional mRNA sequence: 

    AK297740.1 AK308240.1 L36531.1 

    4 DOTS entries:

    DT.312805  DT.312806  DT.91671353  DT.95091367 

    24/40 AceView cDNA sequences (see all 40):

    AI521164 NM_003638 AA131272 BF437627 BF446919 AI658695 BX106890 F01262 
    CB963509 AL697739 BX092288 AI685895 AA630195 AA297173 AA131323 CD357514 
    CD241892 AW771675 CA395504 M85929 AA599597 AI193623 AI023787 AA779994 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA8 expression in normal human tissues (normalized intensities)      ITGA8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGAAAAA
    ITGA8 Expression
    About this image


    ITGA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Lower Urinary Tract (Muscoskeletal System)    fully expand to see all 2 entries
             Human Bladder Smooth Muscle Cells (HBdSMC)   
             urethra   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Conventional Dendritic Cells I Spleen
             plasma cells   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
             DKK1-induced cells ( Derivation of cardiomyocytes from pluripotent stem cells and...
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Gingival Fibroblasts (HGF)   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles

    See ITGA8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA8

    SOURCE GeneReport for Unigene cluster: Hs.171311

    UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708
    Tissue specificity: Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and
    hepatic stellar cells and vascular and visceral smooth muscle (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA8: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA8
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGA8 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga81 , 5 integrin alpha 81, 5 86.03(n)1
    89.17(a)1
      2 (9.12 cM)5
    2412261  NM_001001309.21  NP_001001309.11 
     121066325 
    chicken
    (Gallus gallus)
    Aves ITGA81 integrin, alpha 8 76.03(n)
    77.33(a)
      396225  NM_205288.1  NP_990619.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA86
    integrin, alpha 8
    71(a)
    1 ↔ 1
    6(18898759-19032889)
    zebrafish
    (Danio rerio)
    Actinopterygii itga86
    integrin, alpha 8
    62(a)
    1 ↔ 1
    16(30612031-30742249)
    worm
    (Caenorhabditis elegans)
    Secernentea pat-21 Protein PAT-2 45.88(n)
    34.15(a)
      176240  NM_066547.2  NP_498948.1 


    ENSEMBL Gene Tree for ITGA8 (if available)
    TreeFam Gene Tree for ITGA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA8 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  
    3 SIMAP similar genes for ITGA8 using alignment to 1 protein entry:     ITA8_HUMAN:
    ITGAV    ITGA5    ITGA2B

    ITGA8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4927 SNPs in ITGA8 are shown (see all 4927)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0346824
    ----see VAR_0346822 V L mis40--------
    VAR_0186784
    ----see VAR_0186782 V A mis40--------
    rs112597201,2
    F--15471274(+) TCCATG/TGGATA 1 -- ds5001 ese30--------
    rs1824311061,2
    --15471330(+) ATCAGG/TCATTT 1 -- ds50010--------
    rs22965111,2
    C,F,A,H--15471380(-) AGAGAC/TGAAAT 1 -- ds5001 ese336Minor allele frequency- T:0.31EA NS NA WA CSA 4589
    rs1865645651,2
    --15471432(+) CATACA/GCATTT 1 -- ds50010--------
    rs79002941,2
    C--15471498(+) CTGATG/AGCTTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1906225991,2
    --15471505(+) CTTCTC/TCAGCT 1 -- ds50010--------
    rs93332531,2
    C,F--15471554(-) GAAATT/GGTCCT 1 -- ds50015Minor allele frequency- G:0.07NS CSA WA 262
    rs112597211,2
    --15471563(+) TCTCCA/GAAGTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ITGA8 (15555948 - 15762124 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for ITGA8 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2656916CNV Deletion23128226
    esv2498205CNV Deletion19546169
    nsv894902CNV Loss21882294
    nsv516700CNV Loss19592680
    dgv38n21CNV Gain19592680
    nsv524808CNV Gain19592680
    nsv894903CNV Gain21882294
    esv32914CNV Gain17666407
    nsv523569CNV Gain19592680
    nsv831795CNV Gain17160897


    Human Gene Mutation Database (HGMD): ITGA8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA8
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604063    OMIM disorders: --

    15 diseases for ITGA8:    About MalaCards
    keratopathy    bullous keratopathy    laryngeal squamous cell carcinoma    polycystic kidney disease
    kidney disease    laryngitis    hypertrophic cardiomyopathy    glomerulonephritis
    parkinson's disease    dilated cardiomyopathy    squamous cell carcinoma    alzheimer's disease
    melanoma    neuronitis    hepatitis


    ITGA8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ITGA8
    Human Genome Epidemiology (HuGE) Navigator: ITGA8 (3 documents)

    Export disorders for ITGA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA8 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with ITGA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. (PubMed id 7768999)1, 2, 3, 9 Schnapp L.M.... Pytela R. (1995)
    2. Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). (PubMed id 15579315)1, 2, 9 Ekwa-Ekoka C.... Schnapp L.M. (2004)
    3. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. (PubMed id 18277079)1, 4, 9 Zeltner R....Hartner A. (2008)
    4. Genome-wide association study reveals genetic risk un derlying Parkinson's disease. (PubMed id 19915575)1, 4 SimA^n-SA!nchez J....Gasser T. (2009)
    5. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    8. Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. (PubMed id 12415008)1, 2 Lu M.... Schnapp L.M. (2002)
    9. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. (PubMed id 10504498)1, 2 Hartner A.... Sterzel R.B. (1999)
    10. Expression and promoter analysis of a highly restricte d integrin alpha gene in vascular smooth muscle. (PubMed id 23142384)1 Kitchen C.M....Miano J.M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8516 HGNC: 6144 AceView: ITGA8 Ensembl:ENSG00000077943 euGenes: HUgn8516
    ECgene: ITGA8 Kegg: 8516 H-InvDB: ITGA8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA8 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/itga8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA8 gene:
    Search GeneIP for patents involving ITGA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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