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ITGA8 Gene

protein-coding   GIFtS: 64
GCID: GC10M015555

Integrin, Alpha 8

  See ITGA8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 81 2
Integrin Alpha-82
RHDA15

External Ids:    HGNC: 61441   Entrez Gene: 85162   Ensembl: ENSG000000779437   OMIM: 6040635   UniProtKB: P537083   

Export aliases for ITGA8 gene to outside databases

Previous GC identifers: GC10M015541 GC10M015709 GC10M015563 GC10M015599


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ITGA8 Gene:
ITGA8 (integrin, alpha 8) is a protein-coding gene. Diseases associated with ITGA8 include renal hypodysplasia/aplasia 1, and renal agenesis. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708
Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating
the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array
of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney
genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory
and motor neurons

Gene Wiki entry for ITGA8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA8 gene promoter:
         GR   RP58   ATF-2   FOXD1   CRE-BP1   MEF-2A   AREB6   c-Myb   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA8 promoter sequence
   Search Chromatin IP Primers for ITGA8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p13   HGNC cytogenetic band: 10p13

ITGA8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M015555:  view genomic region     (about GC identifiers)

Start:
15,555,948 bp from pter      End:
15,762,124 bp from pter
Size:
206,177 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708 (See protein sequence)
Recommended Name: Integrin alpha-8 precursor  
Size: 1063 amino acids; 117474 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-8 associates with beta-1
Secondary accessions: B0YJ31 Q5VX94

Explore the universe of human proteins at neXtProt for ITGA8: NX_P53708

Explore proteomics data for ITGA8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn81, Asn122, Asn177, Asn239, Asn302, Asn311, Asn504, Asn601, Asn605, Asn719,
                                 Asn737, Asn753, Asn780, Asn896, Asn923, Asn1005
  • Modification sites at PhosphoSitePlus

  • See ITGA8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003629.1  
    ENSEMBL proteins: 
     ENSP00000367316  
    Reactome Protein details: P53708

    ITGA8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA8
    OriGene Protein Over-expression Lysate for ITGA8
    OriGene MassSpec for ITGA8
    OriGene Custom Protein Services for ITGA8
    GenScript Custom Purified and Recombinant Proteins Services for ITGA8
    Novus Biologicals ITGA8 Protein
    Novus Biologicals ITGA8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA8 

    ITGA8 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA8
    R&D Systems Antibodies for ITGA8 (Integrin alpha 8)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ITGA8
    Novus Biologicals ITGA8 Antibodies
    Abcam antibodies for ITGA8
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ITGA8
    LSBio Antibodies in human, mouse, rat for ITGA8

    ITGA8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGA8
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGA8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P53708

    ProtoNet protein and cluster: P53708

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    Find genes that share domains with ITGA8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA8_HUMAN, P53708
    Function: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating
    the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array
    of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney
    genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory
    and motor neurons

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGA8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGA8:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Itga8):
     behavior/neurological  cellular  hearing/vestibular/ear  mortality/aging  nervous system 
     renal/urinary system  respiratory system 

    Find genes that share phenotypes with ITGA8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itga8tm1Lfr for ITGA8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA8

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA8:
    hsa-mir-615-3p (MIRT040247), hsa-mir-183-5p (MIRT047150)

    Block miRNA regulation of human, mouse, rat ITGA8 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITGA8
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA8
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA8

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA8 (see all 6)
    OriGene ORF clones in mouse, rat for ITGA8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA8 (NM_003638)
    Sino Biological Human cDNA Clone for ITGA8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA8
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA8_HUMAN, P53708: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    extracellular1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS7768999
    GO:0014069postsynaptic density IEA--
    GO:0032591dendritic spine membrane IEA--
    GO:0034678alpha8-beta1 integrin complex TAS--

    Find genes that share ontologies with ITGA8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA8 About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with ITGA8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA8 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 GeneGo (Thomson Reuters) Pathways for ITGA8
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion PLAU signaling

    3 BioSystems Pathways for ITGA8
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    3 Reactome Pathways for ITGA8
        Molecules associated with elastic fibres
    ECM proteoglycans
    Integrin cell surface interactions


    Selected Kegg Pathways  (Kegg details for ITGA8) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA8: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA8 (P537083 ENSP000003673164) via UniProtKB, MINT, STRING, and/or I2D (see all 123)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055563, ENSP000003640944I2D: score=4 STRING: ENSP00000364094
    FN1P027513, ENSP000003468394I2D: score=1 STRING: ENSP00000346839
    QKIQ96PU83, ENSP000003549514I2D: score=1 STRING: ENSP00000354951
    NPNTQ6UXI93, ENSP000003693234I2D: score=2 STRING: ENSP00000369323
    VTNP040043, ENSP000002262184I2D: score=1 STRING: ENSP00000226218
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0007160cell-matrix adhesion NAS7768999
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007399nervous system development ----
    GO:0007420brain development IEA--

    Find genes that share ontologies with ITGA8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGA8 (ITA8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGA8 gene: 
    NM_003638.1  

    Unigene Cluster for ITGA8:

    Integrin, alpha 8
    Hs.171311  [show with all ESTs]
    Unigene Representative Sequence: NM_003638
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378076(uc001ioc.1 uc010qcb.1) ENST00000477064 ENST00000468882

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA8 using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGA8
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA8
    Clone
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    GenScript: all cDNA clones in your preferred vector: ITGA8 (NM_003638)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA8
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA8
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA8
      QuantiFast Probe-based Assays in human, mouse, rat ITGA8

    Additional mRNA sequence: 

    AK297740.1 AK308240.1 L36531.1 

    4 DOTS entries:

    DT.312805  DT.312806  DT.91671353  DT.95091367 

    Selected AceView cDNA sequences (see all 40):

    AA131272 AI658695 AI521164 BF446919 F01262 BX106890 BF437627 NM_003638 
    AA630195 BF437411 CB963509 CA395504 AA599597 AI023787 L36531 CA388792 
    AA131323 AA779994 BX092288 M85929 CD241892 CD357514 AL697739 AI193623 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAAGAAAAA
    ITGA8 Expression
    About this image


    ITGA8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Mesoderm-like cells
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Head Mesenchyme (Muscoskeletal System)
             Frontonasal Process
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
    ITGA8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.171311

    UniProtKB/Swiss-Prot: ITA8_HUMAN, P53708
    Tissue specificity: Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and
    hepatic stellar cells and vascular and visceral smooth muscle (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA8: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA8
    QuantiTect SYBR Green Assays in human, mouse, rat ITGA8
    QuantiFast Probe-based Assays in human, mouse, rat ITGA8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ITGA8 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga81 , 5 integrin alpha 81, 5 86.03(n)1
    89.17(a)1
      2 (9.12 cM)5
    2412261  NM_001001309.21  NP_001001309.11 
     121066325 
    chicken
    (Gallus gallus)
    Aves ITGA81 integrin, alpha 8 76.16(n)
    77.45(a)
      396225  NM_205288.1  NP_990619.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA86
    integrin, alpha 8
    71(a)
    1 ↔ 1
    6(18898759-19032889)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itga81 integrin, alpha 8 70.86(n)
    72.8(a)
      100487624  XM_002939028.2  XP_002939074.2 
    zebrafish
    (Danio rerio)
    Actinopterygii itga86
    integrin, alpha 8
    62(a)
    1 ↔ 1
    16(30612031-30742249) ENSDARG00000078717
    fruit fly
    (Drosophila melanogaster)
    Insecta scb3
    if1
    calcium-dependent cell-matrix adhesion
    cell adhesion more3
    inflated1
    27(a)
    (best of 3)3
    45.31(n)1
    33.72(a)1
      326611  NM_001169307.11  NP_001162778.11 
    worm
    (Caenorhabditis elegans)
    Secernentea pat-21 pat-2 45.93(n)
    33.98(a)
      176240  NM_066547.3  NP_498948.1 


    ENSEMBL Gene Tree for ITGA8 (if available)
    TreeFam Gene Tree for ITGA8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA8 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    3 SIMAP similar genes for ITGA8 using alignment to 1 protein entry:     ITA8_HUMAN:
    ITGAV    ITGA5    ITGA2B

    Find genes that share paralogs with ITGA8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA8 (see all 4927)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112597201,2
    F--15471274(+) TCCATG/TGGATA 1 -- ds5001 ese30--------
    rs1824311061,2
    --15471330(+) ATCAGG/TCATTT 1 -- ds50010--------
    rs22965111,2
    C,F,A,H--15471380(-) AGAGAC/TGAAAT 1 -- ds5001 ese336Minor allele frequency- T:0.31EA NS NA WA CSA 4589
    rs1865645651,2
    --15471432(+) CATACA/GCATTT 1 -- ds50010--------
    rs79002941,2
    C--15471498(+) CTGATG/AGCTTC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1906225991,2
    --15471505(+) CTTCTC/TCAGCT 1 -- ds50010--------
    rs93332531,2
    C,F--15471554(-) GAAATT/GGTCCT 1 -- ds50015Minor allele frequency- G:0.07NS CSA WA 262
    rs112597211,2
    --15471563(+) TCTCCA/GAAGTG 1 -- ds50010--------
    rs1142595611,2
    F--15471569(+) AAGTGC/TGGTGT 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs93332521,2
    C,F--15471706(-) AAAAAA/-GAAGA 1 -- ut31 trp34Minor allele frequency- -:0.01NS NA 140

    HapMap Linkage Disequilibrium report for ITGA8 (15555948 - 15762124 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGA8 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656916CNV Deletion23128226
    esv2498205CNV Deletion19546169
    nsv894902CNV Loss21882294
    nsv516700CNV Loss19592680
    dgv38n21CNV Gain19592680
    nsv524808CNV Gain19592680
    nsv894903CNV Gain21882294
    esv32914CNV Gain17666407
    nsv523569CNV Gain19592680
    nsv831795CNV Gain17160897

    Human Gene Mutation Database (HGMD): ITGA8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA8
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 604063   
    OMIM disorders: 191830  
    2 diseases for ITGA8:    
    About MalaCards
    renal hypodysplasia/aplasia 1    renal agenesis


    Find genes that share disorders with ITGA8           About GenesLikeMe

    Genetic Association Database (GAD): ITGA8
    Human Genome Epidemiology (HuGE) Navigator: ITGA8 (3 documents)

    Export disorders for ITGA8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for ITGA8 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with ITGA8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. (PubMed id 7768999)1, 2, 3, 9 Schnapp L.M.... Pytela R. (J. Cell Sci. 1995)
    2. Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). (PubMed id 15579315)1, 2, 9 Ekwa-Ekoka C.... Schnapp L.M. (Matrix Biol. 2004)
    3. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. (PubMed id 18277079)1, 4, 9 Zeltner R....Hartner A. (Nephron Clin Pract 2008)
    4. Genome-wide association study reveals genetic risk underlying Parkinson's disease. (PubMed id 19915575)1, 4 SimA^n-SA!nchez J....Gasser T. (Nat. Genet. 2009)
    5. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    8. Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. (PubMed id 12415008)1, 2 Lu M.... Schnapp L.M. (J. Cell Sci. 2002)
    9. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. (PubMed id 10504498)1, 2 Hartner A.... Sterzel R.B. (Kidney Int. 1999)
    10. Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle. (PubMed id 23142384)1 Kitchen C.M....Miano J.M. (Gene 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 8516 HGNC: 6144 AceView: ITGA8 Ensembl:ENSG00000077943 euGenes: HUgn8516
    ECgene: ITGA8 Kegg: 8516 H-InvDB: ITGA8

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGA8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA8 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/itga8/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ITGA8 gene:
    Search GeneIP for patents involving ITGA8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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