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Aliases for ITGA8 Gene

Aliases for ITGA8 Gene

  • Integrin, Alpha 8 2 3
  • RHDA1 6

External Ids for ITGA8 Gene

Previous GeneCards Identifiers for ITGA8 Gene

  • GC10M015541
  • GC10M015709
  • GC10M015563
  • GC10M015599

Summaries for ITGA8 Gene

Entrez Gene Summary for ITGA8 Gene

  • Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

GeneCards Summary for ITGA8 Gene

ITGA8 (Integrin, Alpha 8) is a Protein Coding gene. Diseases associated with ITGA8 include renal hypodysplasia/aplasia 1. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. An important paralog of this gene is ITGA2.

UniProtKB/Swiss-Prot for ITGA8 Gene

  • Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

Gene Wiki entry for ITGA8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA8 Gene

Genomics for ITGA8 Gene

Regulatory Elements for ITGA8 Gene

Genomic Location for ITGA8 Gene

Start:
15,513,949 bp from pter
End:
15,720,329 bp from pter
Size:
206,381 bases
Orientation:
Minus strand

Genomic View for ITGA8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA8 Gene

Proteins for ITGA8 Gene

  • Protein details for ITGA8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53708-ITA8_HUMAN
    Recommended name:
    Integrin alpha-8
    Protein Accession:
    P53708
    Secondary Accessions:
    • B0YJ31
    • Q5VX94

    Protein attributes for ITGA8 Gene

    Size:
    1063 amino acids
    Molecular mass:
    117474 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-8 associates with beta-1

neXtProt entry for ITGA8 Gene

Proteomics data for ITGA8 Gene at MOPED

Post-translational modifications for ITGA8 Gene

  • Glycosylation at Asn81, Asn122, Asn177, Asn239, Asn302, Asn311, Asn504, Asn601, Asn605, Asn719, Asn737, Asn753, Asn780, Asn896, Asn923, and Asn1005
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGA8 (Integrin alpha 8)

No data available for DME Specific Peptides for ITGA8 Gene

Domains for ITGA8 Gene

Gene Families for ITGA8 Gene

HGNC:
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGA8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53708

UniProtKB/Swiss-Prot:

ITA8_HUMAN :
  • P53708
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA8: view

Function for ITGA8 Gene

Molecular function for ITGA8 Gene

UniProtKB/Swiss-Prot Function:
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

Gene Ontology (GO) - Molecular Function for ITGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGA8: view
genes like me logo Genes that share phenotypes with ITGA8: view

Animal Models for ITGA8 Gene

MGI Knock Outs for ITGA8:

miRNA for ITGA8 Gene

miRTarBase miRNAs that target ITGA8

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA8 Gene

Localization for ITGA8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA8 Gene

Membrane; Single-pass type I membrane protein. Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA8 Gene COMPARTMENTS Subcellular localization image for ITGA8 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 24439109
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex TAS 7768999
GO:0009986 cell surface IDA 24439109
genes like me logo Genes that share ontologies with ITGA8: view

Pathways for ITGA8 Gene

genes like me logo Genes that share pathways with ITGA8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ITGA8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development IEA --
GO:0001822 kidney development IMP 24439109
GO:0007160 cell-matrix adhesion NAS 7768999
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007420 brain development IEA --
genes like me logo Genes that share ontologies with ITGA8: view

Transcripts for ITGA8 Gene

mRNA/cDNA for ITGA8 Gene

Unigene Clusters for ITGA8 Gene

Integrin, alpha 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA8 Gene

No ASD Table

Relevant External Links for ITGA8 Gene

GeneLoc Exon Structure for
ITGA8
ECgene alternative splicing isoforms for
ITGA8

Expression for ITGA8 Gene

mRNA expression in normal human tissues for ITGA8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA8 Gene

This gene is overexpressed in Artery - Aorta (18.0), Artery - Coronary (9.1), Artery - Tibial (6.0), and Esophagus - Gastroesophageal Junction (5.1).

Protein differential expression in normal tissues for ITGA8 Gene

This gene is overexpressed in Liver (24.6), Urinary Bladder (9.3), Fetal gut (7.8), and Prostate (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGA8 Gene

SOURCE GeneReport for Unigene cluster for ITGA8 Gene Hs.171311

mRNA Expression by UniProt/SwissProt for ITGA8 Gene

P53708-ITA8_HUMAN
Tissue specificity: Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
genes like me logo Genes that share expressions with ITGA8: view

In Situ Assay Products

No data available for Expression partners for ITGA8 Gene

Orthologs for ITGA8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGA8 35
  • 89.36 (n)
  • 90.77 (a)
ITGA8 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA8 35
  • 88.97 (n)
  • 90.56 (a)
ITGA8 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga8 35
  • 86.03 (n)
  • 89.17 (a)
Itga8 16
Itga8 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGA8 35
  • 99.44 (n)
  • 99.34 (a)
ITGA8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga8 35
  • 85.84 (n)
  • 89.08 (a)
oppossum
(Monodelphis domestica)
Mammalia ITGA8 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA8 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA8 35
  • 76.16 (n)
  • 77.45 (a)
ITGA8 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA8 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga8 35
  • 70.86 (n)
  • 72.8 (a)
zebrafish
(Danio rerio)
Actinopterygii itga8 36
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alphaPS4 37
  • 26 (a)
alphaPS5 37
  • 26 (a)
scb 37
  • 27 (a)
if 35
  • 45.31 (n)
  • 33.72 (a)
if 36
  • 23 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000032 35
  • 45.09 (n)
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-2 35
  • 45.93 (n)
  • 33.98 (a)
pat-2 36
  • 26 (a)
OneToMany
Species with no ortholog for ITGA8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA8 Gene

ENSEMBL:
Gene Tree for ITGA8 (if available)
TreeFam:
Gene Tree for ITGA8 (if available)

Paralogs for ITGA8 Gene

Selected SIMAP similar genes for ITGA8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITGA8: view

Variants for ITGA8 Gene

Sequence variations from dbSNP and Humsavar for ITGA8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs13664 -- 15,514,323(-) CAATC(A/C)GTTCT utr-variant-3-prime
rs764565 -- 15,549,971(+) GATGT(G/T)GTTTG intron-variant
rs764566 -- 15,549,854(+) AAGGG(A/G)TTAGT intron-variant
rs867754 -- 15,705,275(-) GAGCA(A/G)AAGGA intron-variant
rs878319 -- 15,515,322(-) AGTTT(C/T)GGGTC utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ITGA8 Gene

Variant ID Type Subtype PubMed ID
nsv894900 CNV Gain 21882294
nsv523569 CNV Gain 19592680
nsv524808 CNV Gain 19592680
dgv38n21 CNV Gain 19592680
esv2656916 CNV Deletion 23128226
nsv516700 CNV Loss 19592680
esv2498205 CNV Deletion 19546169
esv32914 CNV Gain 17666407
nsv894902 CNV Loss 21882294
nsv894903 CNV Gain 21882294
nsv831795 CNV Gain 17160897

Relevant External Links for ITGA8 Gene

HapMap Linkage Disequilibrium report
ITGA8
Human Gene Mutation Database (HGMD)
ITGA8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA8 Gene

Disorders for ITGA8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ITGA8 Gene in MalaCards »

(1) Diseases for ITGA8 Gene including...

(1) OMIM Diseases for ITGA8 Gene (604063)

UniProtKB/Swiss-Prot

ITA8_HUMAN
  • Renal hypodysplasia/aplasia 1 (RHDA1) [MIM:191830]: A perinatally lethal renal disease encompassing a spectrum of kidney development defects, including renal agenesis, bilateral renal aplasia, hypoplasia, (cystic) dysplasia, and severe obstructive uropathy. {ECO:0000269 PubMed:24439109}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ITGA8

Genetic Association Database (GAD)
ITGA8
Human Genome Epidemiology (HuGE) Navigator
ITGA8
genes like me logo Genes that share disorders with ITGA8: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ITGA8 Gene

Publications for ITGA8 Gene

  1. Sequence and tissue distribution of the human integrin alpha 8 subunit: a beta 1-associated alpha subunit expressed in smooth muscle cells. (PMID: 7768999) Schnapp L.M. … Pytela R. (J. Cell Sci. 1995) 2 3 4 23
  2. A promoter polymorphism of the alpha 8 integrin gene and the progression of autosomal-dominant polycystic kidney disease. (PMID: 18277079) Zeltner R. … Hartner A. (Nephron Clin Pract 2008) 3 23 48
  3. Genomic organization and sequence variation of the human integrin subunit alpha8 gene (ITGA8). (PMID: 15579315) Ekwa-Ekoka C. … Schnapp L.M. (Matrix Biol. 2004) 3 4 23
  4. Integrin alpha8beta1 mediates adhesion to LAP-TGFbeta1. (PMID: 12415008) Lu M. … Schnapp L.M. (J. Cell Sci. 2002) 3 4
  5. Alpha8 integrin in glomerular mesangial cells and in experimental glomerulonephritis. (PMID: 10504498) Hartner A. … Sterzel R.B. (Kidney Int. 1999) 3 4

Products for ITGA8 Gene

Sources for ITGA8 Gene

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