Aliases for ITGA6 Gene
External Ids for ITGA6 Gene
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGA6 Gene
ITGA6 (Integrin, Alpha 6) is a Protein Coding gene. Diseases associated with ITGA6 include duodenal atresia and itga6-related epidermolysis bullosa with pyloric atresia. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include integrin binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA6 Gene
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.