Aliases for ITGA6 Gene
External Ids for ITGA6 Gene
Previous GeneCards Identifiers for ITGA6 Gene
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for ITGA6 Gene
ITGA6 (Integrin Subunit Alpha 6) is a Protein Coding gene. Diseases associated with ITGA6 include Epidermolysis Bullosa, Junctional, With Pyloric Stenosis and Itga6-Related Epidermolysis Bullosa With Pyloric Atresia. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include protein complex binding and laminin binding. An important paralog of this gene is ITGA7.
UniProtKB/Swiss-Prot for ITGA6 Gene
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).