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ITGA6 Gene

protein-coding   GIFtS: 71
GCID: GC02P173256

Integrin, Alpha 6

  See ITGA6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 61 2     ITGA6B2
VLA-62 3     Integrin Alpha-62
CD49 Antigen-Like Family Member F2 3     Integrin Alpha6B2
CD49f2     CD49f Antigen3

External Ids:    HGNC: 61421   Entrez Gene: 36552   Ensembl: ENSG000000914097   OMIM: 1475565   UniProtKB: P232293   

Export aliases for ITGA6 gene to outside databases

Previous GC identifers: GC02P171344 GC02P171953 GC02P173494 GC02P173117 GC02P173000 GC02P165170


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA6 Gene:
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins
composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in
different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with
beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface
mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq, Jul 2008)

GeneCards Summary for ITGA6 Gene:
ITGA6 (integrin, alpha 6) is a protein-coding gene. Diseases associated with ITGA6 include duodenal atresia, and itga6-related epidermolysis bullosa with pyloric atresia. GO annotations related to this gene include integrin binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA6_HUMAN, P23229
Function: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor
for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome

Gene Wiki entry for ITGA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA6 gene promoter:
         Max1   p53   AP-1   ATF-2   MyoD   FOXO4   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA6 promoter sequence
   Search Chromatin IP Primers for ITGA6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

ITGA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P173256:  view genomic region     (about GC identifiers)

Start:
173,292,082 bp from pter      End:
173,371,181 bp from pter
Size:
79,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITA6_HUMAN, P23229 (See protein sequence)
Recommended Name: Integrin alpha-6 precursor  
Size: 1130 amino acids; 126606 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with
RAB21
Sequence caution: Sequence=BAG57680.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RMU9 B4DG69 B4DKB8 C4AM96 G5E9H1 Q08443 Q0MRC7 Q14646 Q16508 Q53RX7
Q59HB7 Q86VL6 Q9UCT1 Q9UN03
Alternative splicing: 8 isoforms:  P23229-1   P23229-2   P23229-3   P23229-4   P23229-5   P23229-6   P23229-7   P23229-9   
(Contains a phosphoserine at position 1103)

Explore the universe of human proteins at neXtProt for ITGA6: NX_P23229

Explore proteomics data for ITGA6 at MOPED

Post-translational modifications: 

  • Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation.
    Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction
    of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand1
  • In invasive prostate cancer ITGA6 undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent
    manner enhancing cell invasion and migration in vitro1
  • Glycosylation2 at Asn78, Asn223, Asn323, Asn409, Asn770, Asn787, Asn930, Asn966, Asn997
  • Modification sites at PhosphoSitePlus

  • See ITGA6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000201.2  NP_001073286.1  

    ENSEMBL proteins: 
     ENSP00000413470   ENSP00000386614   ENSP00000264107   ENSP00000406694   ENSP00000394169  
     ENSP00000386896   ENSP00000388435   ENSP00000264106   ENSP00000364369   ENSP00000341078  
    Reactome Protein details: P23229

    ITGA6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA6 (Integrin alpha 6 beta 4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA6
    OriGene Protein Over-expression Lysate for ITGA6
    OriGene MassSpec for ITGA6
    OriGene Custom Protein Services for ITGA6
    GenScript Custom Purified and Recombinant Proteins Services for ITGA6
    Novus Biologicals ITGA6 Proteins
    Novus Biologicals ITGA6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA6 

    ITGA6 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA6
    R&D Systems Antibodies for ITGA6 (Integrin alpha 6/CD49f)
    Cell Signaling Technology (CST) Antibodies for ITGA6 
    OriGene Antibodies for ITGA6
    OriGene Custom Antibody Services for ITGA6
    Novus Biologicals ITGA6 Antibodies
    Abcam antibodies for ITGA6
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGA6
    LSBio Antibodies in human, mouse, rat for ITGA6

    ITGA6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA6
    R&D Systems Proteome Profiler Antibody Arrays for ITGA6 (Integrin alpha 6/CD49f)
    GenScript Custom Assay Services for ITGA6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGA6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    4 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p

    Graphical View of Domain Structure for InterPro Entry P23229

    ProtoNet protein and cluster: P23229

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA6_HUMAN, P23229
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    Find genes that share domains with ITGA6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA6_HUMAN, P23229
    Function: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor
    for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome

         Genatlas biochemistry entry for ITGA6:
    integrin,alpha 6 cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,component of VLA-6 receptor and of hemidesmosomes,mediating cell-extracellular matrix interactions also
    involved in the fertilization of ova and embryonic development,dimerizing with ITGB1 (laminin receptor) or ITGB4
    (component of hemidesmosome)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI--
    GO:0032403protein complex binding ----
    GO:0043236laminin binding IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGA6           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for ITGA6:
     Decreased focal adhesion (FA)   Increased S DNA content  Increased cell number in G1, s  Increased cilium length after  
     S arrest 

         Selected MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itga6) (see all 19):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system  immune system 
     integument  limbs/digits/tail  mortality/aging  nervous system  other 

    Find genes that share phenotypes with ITGA6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itga6tm1Egl for ITGA6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA6:
    hsa-mir-34a-5p (MIRT025291), hsa-mir-15b-5p (MIRT046458), hsa-mir-1 (MIRT023546), hsa-mir-30a-5p (MIRT028474), hsa-mir-32-5p (MIRT028271)

    Block miRNA regulation of human, mouse, rat ITGA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA6 (see all 53):
    hsa-miR-3164 hsa-miR-300 hsa-miR-199a-3p hsa-miR-29a hsa-miR-25 hsa-miR-30d hsa-miR-105 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidITGA6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA6
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA6

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA6 (see all 11)
    OriGene ORF clones in mouse, rat for ITGA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGA6 (NM_001079818)
    Sino Biological Human cDNA Clone for ITGA6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA6
    Addgene plasmids for ITGA6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA6
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA6_HUMAN, P23229: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytoskeleton2
    cytosol2
    peroxisome2
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0005913cell-cell adherens junction IEA--
    GO:0008305integrin complex ----
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with ITGA6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA6 About   (see all 39)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Alpha6-Beta4 Integrin Signaling Pathway
    Alpha6-Beta4 Integrin Signaling Pathway
    Type I hemidesmosome assembly0.00
    4Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64


    Find genes that share SuperPaths with ITGA6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA6 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for ITGA6
        Angiogenesis
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ITGA6
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    Selected BioSystems Pathways for ITGA6 (see all 8)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Alpha6-Beta4 Integrin Signaling Pathway
    Arrhythmogenic right ventricular cardiomyopathy
    a6b1 and a6b4 Integrin signaling


    Selected Reactome Pathways for ITGA6 (see all 6)
        Laminin interactions
    Integrin cell surface interactions
    Type I hemidesmosome assembly
    Assembly of collagen fibrils and other multimeric structures
    Basigin interactions


    Selected Kegg Pathways  (Kegg details for ITGA6) (see all 12):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA6: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA6 (P232291, 2, 3 ENSP000003868964) via UniProtKB, MINT, STRING, and/or I2D (see all 180)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055562, 3, ENSP000003640944MINT-8407185 I2D: score=5 STRING: ENSP00000364094
    CD63P089622, 3, ENSP000002578574MINT-8407185 I2D: score=2 STRING: ENSP00000257857
    ITGB4P161441, 3, ENSP000002001814EBI-2436548,EBI-948678 I2D: score=2 STRING: ENSP00000200181
    PDIA3P301012, 3MINT-4301321 I2D: score=1 
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007044cell-substrate junction assembly TAS9185503
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0010811positive regulation of cell-substrate adhesion IEA--

    Find genes that share ontologies with ITGA6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGA6 (ITA6)

    Selected Novoseek inferred chemical compound relationships for ITGA6 gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    kalinin 76.2 3 17129354 (1), 8705822 (1), 7551559 (1)
    sikvav 63 2 17591960 (1), 17235355 (1)
    matrigel 57.5 5 12356873 (1), 1280276 (1), 16154099 (1), 19405119 (1) (see all 5)
    yigsr 54.2 1 8035652 (1)
    hpvs 25.6 1 16376962 (1)
    retinoic acid 21.6 7 8704182 (3), 17379860 (1), 16261612 (1), 8609714 (1) (see all 5)
    heparan sulfate 15 3 16376962 (2)
    herbimycin a 13.1 1 9358755 (1)
    retinoid 4.27 1 9024307 (1)
    agarose 0 1 8929432 (1)



    Find genes that share compounds with ITGA6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGA6 gene (2 alternative transcripts): 
    NM_000210.2  NM_001079818.1  

    Unigene Cluster for ITGA6:

    Integrin, alpha 6
    Hs.133397  [show with all ESTs]
    Unigene Representative Sequence: NM_000210
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412899 ENST00000409532 ENST00000264107 ENST00000442250(uc010fql.2 uc010fqk.1)
    ENST00000458358 ENST00000409080 ENST00000497107 ENST00000416789 ENST00000469534
    ENST00000470259 ENST00000475302 ENST00000264106(uc002uhp.1) ENST00000375221(uc002uho.1)
    ENST00000343713(uc010zdy.1 uc010fqm.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA6 (see all 53):
    hsa-miR-3164 hsa-miR-300 hsa-miR-199a-3p hsa-miR-29a hsa-miR-25 hsa-miR-30d hsa-miR-105 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidITGA6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGA6
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA6
    Clone
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    OriGene clones in human, mouse for ITGA6 (see all 11)
    OriGene ORF clones in mouse, rat for ITGA6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGA6 (NM_001079818)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA6
    Addgene plasmids for ITGA6 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA6
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA6
      QuantiFast Probe-based Assays in human, mouse, rat ITGA6

    Additional mRNA sequence: 

    AB208842.1 AF401206.1 AK294436.1 AK296496.1 AK307777.1 AK311695.1 BC007002.1 BC050585.1 
    BC136455.1 BC136456.1 DQ858220.1 EF491782.1 EF491790.1 EF491812.1 S66196.1 S66213.1 
    X53586.1 X59512.1 

    16 DOTS entries:

    DT.100797201  DT.95166149  DT.65285734  DT.449080  DT.120966874  DT.95360545  DT.92449387  DT.86852253 
    DT.120966835  DT.100797203  DT.120966832  DT.100797199  DT.40249838  DT.120966784  DT.418472  DT.95166144 

    Selected AceView cDNA sequences (see all 359):

    BC050585 F01918 AL121316 AI601268 AA344846 BP354305 AW590978 AI745043 
    AI742407 AA814514 H13417 BM800707 BU620869 BU633378 F04601 AW516434 
    BQ224040 AI095118 AI478635 BM828809 AA353560 BU629997 AW439417 AA969146 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITGA6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a ·
    SP1:                                                                                                                                                  -     -   
    SP2:                                                                                                                                                  -     -   
    SP3:                                                                                                                                            -     -     -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b
    SP1:                          -                                 
    SP2:                          -           -     -               
    SP3:                          -                                 
    SP4:                          -                                 
    SP5:                                                            


    ECgene alternative splicing isoforms for ITGA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAGAAATT
    ITGA6 Expression
    About this image


    ITGA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 8 entries
             2-Cell Embryo Zygote
             Human embryonic stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 6 entries
             2-Cell Embryo Zygote
     
     Zygote (Early Embryonic Tissues)    fully expand to see all 5 entries
             2-Cell Embryo Zygote
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
     
     Eye (Sensory Organs)    fully expand to see all 7 entries
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
             Limbal epithelial stem cells (family)
    ITGA6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.133397

    UniProtKB/Swiss-Prot: ITA6_HUMAN, P23229
    Tissue specificity: Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment
    X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon,
    duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the
    ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic
    segment A and isoforms containing segment B are detected while in others, only isoforms containing one
    cytoplasmic segment are found (segment A in epidermis and segment B in kidney)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA6: 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Mesenchymal Stem Cell in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ITGA6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga61 , 5 integrin alpha 61, 5 86.77(n)1
    93.13(a)1
      2 (42.79 cM)5
    164031  NM_001277970.11  NP_001264899.11 
     717456165 
    chicken
    (Gallus gallus)
    Aves ITGA61 integrin, alpha 6 72.59(n)
    72.36(a)
      396226  NM_205289.1  NP_990620.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA66
    integrin, alpha 6
    62(a)
    1 ↔ 1
    GL343353.1(149469-212940)
    African clawed frog
    (Xenopus laevis)
    Amphibia INTA62 integrin alpha 6 subunit 75.99(n)    L35051.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itga6a1 integrin, alpha 6a 63.58(n)
    64.43(a)
      503893  XM_005167410.1  XP_005167467.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mew1 , 3 wing morphogenesis cell adhesion
    receptor3
    multiple edematous wings1
    29(a)
    (best of 2)3
    44.71(n)1
    34.85(a)1
      322751  NM_078590.21  NP_511145.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ina-11 , 3 Integrin alpha chain3
    ina-11
    27(a)3
    46.52(n)1
    33.3(a)1
      III(9240086-9244462)3
    1762961  NM_066631.41  NP_499032.11 


    ENSEMBL Gene Tree for ITGA6 (if available)
    TreeFam Gene Tree for ITGA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA6 gene
    ITGA12  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    4 SIMAP similar genes for ITGA6 using alignment to 3 protein entries:     ITA6_HUMAN (see all proteins):
    ITGA7 variant protein    ITGA7    ITGA3    ITGA4

    Find genes that share paralogs with ITGA6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA6 (see all 1942)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1505624841,2
    Cuntested1172702332(+) ACCCTC/TGTGTC 2 -- int10--------
    rs21416981,2
    C,F,H--172685064(-) TGGTTG/ACTGAA 2 -- us2k134Minor allele frequency- A:0.15NS EA NA WA CSA 3205
    rs1904725501,2
    --172685096(+) CTGGCC/TGAGTA 2 -- us2k10--------
    rs760585341,2
    C,F--172685231(+) TGCAAG/ATACTT 2 -- us2k12Minor allele frequency- A:0.07NA EA 240
    rs714152981,2
    C,F--172685443(+) CTGTGG/AGGACC 2 -- us2k13Minor allele frequency- A:0.04NA 124
    rs1409997871,2
    --172685452(+) CCCTTA/GATGAT 2 -- us2k10--------
    rs730234721,2
    C,F--172685464(+) TTCACG/ACAGCT 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1467500861,2
    --172685590(+) TTCCAA/GTGCAG 2 -- us2k10--------
    rs1488334351,2
    --172685706(+) ACCATG/TGGGTT 2 -- us2k10--------
    rs1434570981,2
    --172685832(+) ATATAG/TGCTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGA6 (173292082 - 173371181 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ITGA6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677918CNV Deletion23128226
    esv269531CNV Insertion20981092
    esv272846CNV Insertion20981092
    nsv875414CNV Gain21882294

    Human Gene Mutation Database (HGMD): ITGA6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA6
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 147556   
    OMIM disorders: 226730  
    UniProtKB/Swiss-Prot: ITA6_HUMAN, P23229
  • Epidermolysis bullosa letalis, with pyloric atresia (EB-PA) [MIM:226730]: An autosomal recessive,
    frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable
    effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and
    gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation
    rather than a scarring process secondary to epidermolysis bullosa. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 12 diseases for ITGA6:    
    About MalaCards
    duodenal atresia    itga6-related epidermolysis bullosa with pyloric atresia    epidermolysis bullosa, junctional, with pyloric stenosis    cicatricial pemphigoid
    skin disease    epidermolysis bullosa with pyloric atresia    ocular cicatricial pemphigoid    bullous skin disease
    mucous membrane pemphigoid    junctional epidermolysis bullosa    gastrointestinal stromal tumor    bullous pemphigoid

    3 diseases from the University of Copenhagen DISEASES database for ITGA6:
    Epidermolysis bullosa     Bullous pemphigoid     Cancer

    Find genes that share disorders with ITGA6           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGA6 gene (see all 51)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pyloric atresia 88.4 7 14675179 (2), 18779879 (1), 9546354 (1), 18955862 (1) (see all 6)
    epidermolysis bullosa junctional 82.9 6 18779879 (1), 9158140 (1), 9804362 (1), 14675179 (1) (see all 6)
    eb-pa 81.3 2 9892956 (1), 11328943 (1)
    lethal junctional epidermolysis bullosa 73.1 1 14675179 (1)
    pemphigoid bullous 71.3 17 11669480 (2), 16126949 (2), 9205513 (1), 9389789 (1) (see all 14)
    epidermolysis bullosa 69.5 10 8712842 (3), 9742403 (1), 9546354 (1), 1694890 (1) (see all 6)
    pemphigoid cicatricial 61.4 1 16810295 (1)
    ocular cicatricial pemphigoid 41 1 16810295 (1)
    metastasis 37.9 22 15679046 (4), 8105045 (4), 7681030 (2), 10048983 (1) (see all 13)
    tumors 35.3 50 7586806 (4), 7681030 (2), 8344495 (2), 10717240 (2) (see all 28)

    GeneTests: ITGA6
    GeneReviews: ITGA6
    Genetic Association Database (GAD): ITGA6
    Human Genome Epidemiology (HuGE) Navigator: ITGA6 (11 documents)

    Export disorders for ITGA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA6 gene, integrated from 10 sources (see all 443):
    (articles sorted by number of sources associating them with ITGA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrin alpha6 cleavage: a novel modification to modulate cell migration. (PubMed id 17303120)1, 2, 9 Pawar S.C....Cress A.E. (Exp. Cell Res. 2007)
    2. Inherited genetic markers discovered to date are able to identify a significant number of men at considerably elevated risk for prostate cancer. (PubMed id 20878950)1, 4 Sun J....Xu J. (Prostate 2011)
    3. Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. (PubMed id 20485444)1, 4 Wang Y....Huang W. (J. Hum. Genet. 2010)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    5. Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. (PubMed id 20564319)1, 4 Kim S.T....Sun J. (Prostate 2010)
    6. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. (PubMed id 19767753)1, 4 Eeles R.A....Easton D.F. (Nat. Genet. 2009)
    7. Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PubMed id 18550570)1, 4 Brendle A....FAPrsti A. (Carcinogenesis 2008)
    8. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    9. An alternatively spliced exon in the extracellular domain of the human alpha 6 integrin subunit -- functional analysis of the alpha 6 integrin variants. (PubMed id 7583007)1, 2 Delwel G.O.... Sonnenberg A. (Cell Adhes. Commun. 1995)
    10. The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor. (PubMed id 8360143)1, 2 Hogervorst F.... Sonnenberg A. (J. Biol. Chem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3655 HGNC: 6142 AceView: ITGA6 Ensembl:ENSG00000091409 euGenes: HUgn3655
    ECgene: ITGA6 Kegg: 3655 H-InvDB: ITGA6

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGA6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA6 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ITGA6[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGA6 gene:
    Search GeneIP for patents involving ITGA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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