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Aliases for ITGA5 Gene

Aliases for ITGA5 Gene

  • Integrin Subunit Alpha 5 2 3 5
  • Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide) 2 3
  • Fibronectin Receptor, Alpha Polypeptide 2 3
  • Fibronectin Receptor Subunit Alpha 3 4
  • CD49 Antigen-Like Family Member E 3 4
  • Integrin Alpha-F 3 4
  • VLA-5 3 4
  • FNRA 3 4
  • Very Late Activation Protein 5, Alpha Subunit 3
  • Fibronectin Receptor, Alpha Subunit 3
  • Integrin Alpha-5 3
  • CD49e Antigen 4
  • CD49e 3
  • VLA5A 3

External Ids for ITGA5 Gene

Previous HGNC Symbols for ITGA5 Gene

  • FNRA

Previous GeneCards Identifiers for ITGA5 Gene

  • GC12M054915
  • GC12M054505
  • GC12M053075
  • GC12M054789
  • GC12M051828

Summaries for ITGA5 Gene

Entrez Gene Summary for ITGA5 Gene

  • The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

GeneCards Summary for ITGA5 Gene

ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Colon Carcinoma In Situ and Retinitis Pigmentosa 60. Among its related pathways are Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Hematopoietic cell lineage. GO annotations related to this gene include integrin binding and epidermal growth factor receptor binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA5 Gene

  • Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).

  • (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:24478423). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).

Tocris Summary for ITGA5 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGA5 Gene

Additional gene information for ITGA5 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA5 Gene

Genomics for ITGA5 Gene

Regulatory Elements for ITGA5 Gene

Enhancers for ITGA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H054354 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +61.5 61459 6.6 FEZF1 YBX1 YY1 ZNF143 SP3 MCM3 NFYC MEF2D ZNF610 GLIS1 SP1 PCBP2 ENSG00000258344 CBX5 GPR84 ZNF385A MAP3K12 ATF7 LOC100652999 HNRNPA1
GH12H054392 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +25.8 25775 2 HDAC1 TBL1XR1 RAD21 CBX5 ZNF143 RUNX3 SMARCA5 ZNF654 ZC3H11A REST GPR84 GTSF1 ITGA5 ZNF385A MIR148B HNRNPA1 RNU6-950P COPZ1 TARBP2 NCKAP1L
GH12H054381 1.6 Ensembl ENCODE dbSUPER 11.7 +32.7 32720 10.5 HDGF PKNOX1 FOS SP3 ZNF592 SMARCA4 GLIS1 ZNF624 NBN HMBOX1 LOC105378250 GPR84 OR10A7 OR6C74 MAP3K12 ZNF385A MIR148B ITGA5 RNU6-950P COPZ1
GH12H054367 1.6 Ensembl ENCODE dbSUPER 10.9 +49.1 49121 4.9 PKNOX1 ARNT SIN3A ZNF2 ZNF143 DEK ZC3H11A REST SMARCB1 ZNF592 MIR148B MAP3K12 ENSG00000260470 CBX5 ITGA5 GPR84 FLJ12825 ZNF385A HNRNPA1
GH12H054439 1.3 Ensembl ENCODE dbSUPER 12.2 -20.3 -20336 1 CTCF ARNT MAX ZNF384 RAD21 RFX5 CC2D1A SMC3 ZNF143 IKZF2 GTSF1 ITGA5 ZNF385A GPR84 NCKAP1L RNU6-950P COPZ1 LINC01154
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITGA5 on UCSC Golden Path with GeneCards custom track

Promoters for ITGA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052365 960 2201 SIN3A GLIS2 FOS ATF7 SP3 REST SMARCB1 ZNF623 SMARCA4 GLIS1

Genomic Locations for ITGA5 Gene

Genomic Locations for ITGA5 Gene
chr12:54,395,261-54,419,460
(GRCh38/hg38)
Size:
24,200 bases
Orientation:
Minus strand
chr12:54,789,045-54,813,244
(GRCh37/hg19)

Genomic View for ITGA5 Gene

Genes around ITGA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA5 Gene

Proteins for ITGA5 Gene

  • Protein details for ITGA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08648-ITA5_HUMAN
    Recommended name:
    Integrin alpha-5
    Protein Accession:
    P08648
    Secondary Accessions:
    • Q96HA5

    Protein attributes for ITGA5 Gene

    Size:
    1049 amino acids
    Molecular mass:
    114536 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with CIB1. ITGA5:ITGB1 interacts with NOV. ITGA5:ITGB1 interacts with FBN1 (PubMed:12807887, PubMed:17158881).
    • (Microbial infection) Integrin ITGA5:ITGB1 interacts with human metapneumovirus fusion protein.
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human parvovirus B19 capsid proteins.
    • (Microbial infection) Interacts with HIV-1 Tat.

    Three dimensional structures from OCA and Proteopedia for ITGA5 Gene

neXtProt entry for ITGA5 Gene

Post-translational modifications for ITGA5 Gene

  • Proteolytic cleavage by PCSK5 mediates activation of the precursor.
  • Ubiquitination at isoforms=215
  • Glycosylation at posLast=8484, isoforms=182, isoforms=297, posLast=307307, posLast=316316, isoforms=524, isoforms=530, isoforms=593, isoforms=609, posLast=675675, isoforms=712, isoforms=724, posLast=771771, posLast=773773, and posLast=868868
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA5 Gene

Antibody Products

  • R&D Systems Antibodies for ITGA5 (Integrin alpha 5/CD49e)
  • Cell Signaling Technology (CST) Antibodies for ITGA5 (ITGA5)

No data available for DME Specific Peptides for ITGA5 Gene

Domains & Families for ITGA5 Gene

Gene Families for ITGA5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ITGA5 Gene

Graphical View of Domain Structure for InterPro Entry

P08648

UniProtKB/Swiss-Prot:

ITA5_HUMAN :
  • Belongs to the integrin alpha chain family.
Family:
  • Belongs to the integrin alpha chain family.
genes like me logo Genes that share domains with ITGA5: view

Function for ITGA5 Gene

Molecular function for ITGA5 Gene

GENATLAS Biochemistry:
integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor
UniProtKB/Swiss-Prot Function:
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for human metapneumovirus (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:24478423). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions (PubMed:10397733).

Gene Ontology (GO) - Molecular Function for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005161 platelet-derived growth factor receptor binding TAS 19267251
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 12695522
genes like me logo Genes that share ontologies with ITGA5: view
genes like me logo Genes that share phenotypes with ITGA5: view

Animal Models for ITGA5 Gene

MGI Knock Outs for ITGA5:

Clone Products

  • Addgene plasmids for ITGA5
  • R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA5 Gene

Localization for ITGA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA5 Gene

Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA5 gene
Compartment Confidence
plasma membrane 5
nucleus 3
endoplasmic reticulum 3
golgi apparatus 3
extracellular 2
cytoskeleton 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle TAS 11919189
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS,IEA --
genes like me logo Genes that share ontologies with ITGA5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ITGA5 Gene

Pathways & Interactions for ITGA5 Gene

genes like me logo Genes that share pathways with ITGA5: view

Pathways by source for ITGA5 Gene

SIGNOR curated interactions for ITGA5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis TAS 19267251
GO:0007044 cell-substrate junction assembly IEA --
GO:0007155 cell adhesion TAS 2454952
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0007159 leukocyte cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with ITGA5: view

Drugs & Compounds for ITGA5 Gene

(17) Drugs for ITGA5 Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Resveratrol Experimental, Investigational Pharma Target 123
Cilengitide Investigational Pharma inhibitor Integrin inhibitor for αvβ3 and αvβ5, Integrins 0
Cyclo (-RGDfK) Pharma Inhibitor of αvβ3 integrin 0
RGD (Arg-Gly-Asp) Peptides Pharma Inhibits integrin binding to RGD motifs 0
Zaurategrast Pharma Integrin inhibitor 0

(5) Additional Compounds for ITGA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for ITGA5 Gene

Compound Action Cas Number
A 205804 Selective inhibitor of E-selectin and ICAM-1 expression 251992-66-2
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
GR 144053 trihydrochloride Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic 1215333-48-4
Obtustatin Potent and selective alpha1beta1 inhibitor
P11 Potent antagonist of alphavbeta3-vitronectin interaction; antiangiogenic 848644-86-0

(4) ApexBio Compounds for ITGA5 Gene

Compound Action Cas Number
Cilengitide Integrin inhibitor for αvβ3 and αvβ5 188968-51-6
Cyclo (-RGDfK) Inhibitor of αvβ3 integrin 161552-03-0
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
Zaurategrast Integrin inhibitor 455264-31-0
genes like me logo Genes that share compounds with ITGA5: view

Drug Products

Transcripts for ITGA5 Gene

Unigene Clusters for ITGA5 Gene

Integrin, alpha 5 (fibronectin receptor, alpha polypeptide):
Representative Sequences:

Clone Products

  • Addgene plasmids for ITGA5
  • R&D Systems cDNA Clones for ITGA5 (Integrin alpha 5/CD49e)

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ·
SP1: - - - - -
SP2: - -
SP3: - - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 19d ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a · 32b · 32c · 32d
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: -
SP8: -
SP9:
SP10:

Relevant External Links for ITGA5 Gene

GeneLoc Exon Structure for
ITGA5
ECgene alternative splicing isoforms for
ITGA5

Expression for ITGA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITGA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA5 Gene

This gene is overexpressed in Artery - Tibial (x8.6) and Colon - Sigmoid (x6.1).

Protein differential expression in normal tissues from HIPED for ITGA5 Gene

This gene is overexpressed in Urinary Bladder (22.7), Seminal vesicle (10.5), and Colon muscle (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGA5 Gene



NURSA nuclear receptor signaling pathways regulating expression of ITGA5 Gene:

ITGA5

SOURCE GeneReport for Unigene cluster for ITGA5 Gene:

Hs.505654

Evidence on tissue expression from TISSUES for ITGA5 Gene

  • Liver(4.3)
  • Lung(4)
  • Nervous system(3.3)
  • Bone marrow(2.9)
  • Blood(2.8)
  • Intestine(2.5)
  • Heart(2.2)
  • Kidney(2.1)
  • Muscle(2.1)
  • Skin(2.1)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ITGA5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITGA5 Gene

Orthologs for ITGA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA5 33 34
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia ITGA5 33 34
  • 90.44 (n)
dog
(Canis familiaris)
Mammalia ITGA5 33 34
  • 88.37 (n)
mouse
(Mus musculus)
Mammalia Itga5 33 16 34
  • 87.45 (n)
rat
(Rattus norvegicus)
Mammalia Itga5 33
  • 87.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA5 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 20 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ITGA5 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga5 33
  • 65.84 (n)
Str.3950 33
African clawed frog
(Xenopus laevis)
Amphibia itga5-A 33
zebrafish
(Danio rerio)
Actinopterygii itga5 33 34
  • 61.05 (n)
fruit fly
(Drosophila melanogaster)
Insecta if 35 34
  • 31 (a)
alphaPS4 35
  • 26 (a)
alphaPS5 35
  • 26 (a)
scb 35
  • 24 (a)
worm
(Caenorhabditis elegans)
Secernentea F54F2.1 35
  • 30 (a)
pat-2 34
  • 26 (a)
OneToMany
ina-1 35
  • 25 (a)
Species where no ortholog for ITGA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA5 Gene

ENSEMBL:
Gene Tree for ITGA5 (if available)
TreeFam:
Gene Tree for ITGA5 (if available)

Paralogs for ITGA5 Gene

(5) SIMAP similar genes for ITGA5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ITGA5: view

Variants for ITGA5 Gene

Sequence variations from dbSNP and Humsavar for ITGA5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000195737 -- 54,396,683(+) GCTTC(-/TGTT)TGTTT intron-variant
rs1000212357 -- 54,411,113(+) TGCCT(C/T)GGCCT intron-variant
rs1000214590 -- 54,420,616(+) AGATC(A/G)CTTTT intron-variant, upstream-variant-2KB
rs1000378670 -- 54,414,220(+) CCCTG(C/T)CAACA intron-variant
rs1000676153 -- 54,415,108(+) GCGCC(A/G)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA5 Gene

Variant ID Type Subtype PubMed ID
esv2745915 CNV deletion 23290073
esv3549239 CNV deletion 23714750
nsv559000 CNV loss 21841781

Variation tolerance for ITGA5 Gene

Residual Variation Intolerance Score: 5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA5 Gene

Human Gene Mutation Database (HGMD)
ITGA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA5 Gene

Disorders for ITGA5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ITGA5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
colon carcinoma in situ
  • carcinoma in situ of colon
retinitis pigmentosa 60
  • rp60
congenital epulis
  • congenital epulides
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search ITGA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGA5

Genetic Association Database (GAD)
ITGA5
Human Genome Epidemiology (HuGE) Navigator
ITGA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGA5
genes like me logo Genes that share disorders with ITGA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA5 Gene

Publications for ITGA5 Gene

  1. Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis. (PMID: 24478423) Wei Y … Li J (Journal of virology 2014) 3 4 60
  2. Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity. (PMID: 24011356) Freeman TC … Parise LV (Biochemistry 2013) 3 4 60
  3. Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor. (PMID: 22451694) Nagae M … Takagi J (The Journal of cell biology 2012) 3 4 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. VLA-5-mediated adhesion to fibronectin accelerates hemin-stimulated erythroid differentiation of K562 cells through induction of VLA-4 expression. (PMID: 19460753) Tanaka R … Fukai F (The Journal of biological chemistry 2009) 3 22 60

Products for ITGA5 Gene

  • Addgene plasmids for ITGA5

Sources for ITGA5 Gene