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ITGA5 Gene

protein-coding   GIFtS: 72
GCID: GC12M054789

Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide)


(Previous symbol: FNRA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide)1 2     VLA5A2 5
FNRA1 2 3 5     CD49e2
Fibronectin Receptor Subunit Alpha2 3     Fibronectin Receptor, Alpha Subunit2
Integrin Alpha-F2 3     Integrin Alpha-52
VLA-52 3     Very Late Activation Protein 5, Alpha Subunit2
CD49 Antigen-Like Family Member E2 3     CD49e Antigen3

External Ids:    HGNC: 61411   Entrez Gene: 36782   Ensembl: ENSG000001616387   OMIM: 1356205   UniProtKB: P086483   

Export aliases for ITGA5 gene to outside databases

Previous GC identifers: GC12M054915 GC12M054505 GC12M053075 GC12M051828


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA5 Gene:
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane
proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5
undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy
chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to
participate in cell-surface mediated signalling. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA5 Gene:
ITGA5 (integrin, alpha 5 (fibronectin receptor, alpha polypeptide)) is a protein-coding gene. Diseases associated with ITGA5 include gastric cardia adenocarcinoma, and adenomyosis. GO annotations related to this gene include integrin binding and vascular endothelial growth factor receptor 2 binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648
Function: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D
in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance
angiogenesis in Kaposi's sarcoma lesions

summary for ITGA5 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA5 gene promoter:
         AP-2alpha isoform 3   AP-1   ATF-2   AP-2alpha isoform 2   PPAR-gamma1   PPAR-gamma2   AP-2alpha isoform 4   c-Jun   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA5 promoter sequence
   Search Chromatin IP Primers for ITGA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q11-q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q11-q13

ITGA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054789:  view genomic region     (about GC identifiers)

Start:
54,789,045 bp from pter      End:
54,813,244 bp from pter
Size:
24,200 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648 (See protein sequence)
Recommended Name: Integrin alpha-5 precursor  
Size: 1049 amino acids; 114536 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21
and COMP. Interacts with HIV-1 Tat. Interacts with CIB1
2 PDB 3D structures from and Proteopedia for ITGA5:
3VI3 (3D)        3VI4 (3D)    
Secondary accessions: Q96HA5

Explore the universe of human proteins at neXtProt for ITGA5: NX_P08648

Explore proteomics data for ITGA5 at MOPED

Post-translational modifications: 

  • Proteolytic cleavage by PCSK5 mediates activation of the precursor1
  • Ubiquitination2 at Lys215
  • Glycosylation2 at Asn84, Asn182, Asn297, Asn307, Asn316, Asn524, Asn530, Asn593, Asn609, Asn675,
                                 Asn712, Asn724, Asn771, Asn773, Asn868
  • Modification sites at PhosphoSitePlus

  • See ITGA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002196.2  
    ENSEMBL proteins: 
     ENSP00000293379   ENSP00000450267   ENSP00000405865   ENSP00000447347  
    Reactome Protein details: P08648

    ITGA5 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ITGA5 Protein
    R&D Systems Recombinant & Natural Proteins for ITGA5 (Integrin alpha 5 beta 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ITGA5
    OriGene Protein Over-expression Lysate for ITGA5
    OriGene MassSpec for ITGA5
    OriGene Custom Protein Services for ITGA5
    GenScript Custom Purified and Recombinant Proteins Services for ITGA5
    Novus Biologicals ITGA5 Protein
    Novus Biologicals ITGA5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ITGA5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA5
    R&D Systems Antibodies for ITGA5 (Integrin alpha 5/CD49e)
    Cell Signaling Technology (CST) Antibodies for ITGA5 
    OriGene Antibodies for ITGA5
    OriGene Custom Antibody Services for ITGA5
    Novus Biologicals ITGA5 Antibodies
    Abcam antibodies for ITGA5
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGA5
    LSBio Antibodies in human, mouse, rat for ITGA5

    ITGA5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA5
    R&D Systems ELISAs for ITGA5 (Integrin alpha 5/CD49e, Integrin alpha 5 beta 1)         (see all)
    GenScript Custom Assay Services for ITGA5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P08648

    ProtoNet protein and cluster: P08648

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA5_HUMAN, P08648
    Function: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D
    in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance
    angiogenesis in Kaposi's sarcoma lesions

         Genatlas biochemistry entry for ITGA5:
    integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra
    cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various
    signaling molecules within cells,complexing with ITGB1 in fibronectin receptor

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005154epidermal growth factor receptor binding IEA--
    GO:0005161platelet-derived growth factor receptor binding TAS19267251
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI14970227
    GO:0043184vascular endothelial growth factor receptor 2 binding TAS19267251
         
    ITGA5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ITGA5:
     Increased cell number in G1, s  Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itga5):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     mortality/aging  nervous system  normal 

    ITGA5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGA5: Itga5tm1Hyn Itga5tm2.1Hyn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA5:
    hsa-mir-31-5p (MIRT004976), hsa-mir-484 (MIRT042174), hsa-mir-1229-3p (MIRT036327), hsa-mir-148b-3p (MIRT007314), hsa-mir-183-5p (MIRT047079), hsa-mir-92a-3p (MIRT003031), hsa-mir-98-5p (MIRT027753)

    Block miRNA regulation of human, mouse, rat ITGA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA5 (see all 57):
    hsa-miR-194* hsa-miR-1321 hsa-miR-328 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidITGA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA5
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA5

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA5 (see all 6)
    OriGene ORF clones in mouse, rat for ITGA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA5 (NM_002205)
    Sino Biological Human cDNA Clone for ITGA5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA5
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA5_HUMAN, P08648: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    cytosol2
    extracellular2
    golgi apparatus2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle TAS11919189
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005911colocalizes with cell-cell junction IDA14970227
    GO:0005925colocalizes with focal adhesion IDA14970227

    ITGA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA5 About   (see all 46)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3VEGFR3 signaling in lymphatic endothelium
    VEGFR3 signaling in lymphatic endothelium
    Fibronectin matrix formation0.00
    4Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGA5
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA5 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 Cell Signaling Technology (CST) Pathways for ITGA5
        Angiogenesis
    Adhesion

    Selected GeneGo (Thomson Reuters) Pathways for ITGA5 (see all 8)
        Cell adhesion Integrin inside-out signaling
    Signal transduction PTEN pathway
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Development VEGF-family signaling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    Selected BioSystems Pathways for ITGA5 (see all 8)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Syndecan-2-mediated signaling events
    VEGFR3 signaling in lymphatic endothelium


    5 Reactome Pathways for ITGA5
        Signal transduction by L1
    Integrin cell surface interactions
    Elastic fibre formation
    Fibronectin matrix formation
    Cell surface interactions at the vascular wall


    Selected Kegg Pathways  (Kegg details for ITGA5) (see all 14):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage


    ITGA5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA5 (see all 8): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA5 (P086481, 2, 3 ENSP000002933794) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENGP178131, 2EBI-1382311,EBI-2834630 MINT-8410638 MINT-8415270 MINT-8415254 MINT-8415288
    ITGB1P055562, 3, ENSP000003640944MINT-8216012 MINT-8216001 I2D: score=4 STRING: ENSP00000364094
    FN1P027512, 3, ENSP000003468394MINT-1781205 I2D: score=5 STRING: ENSP00000346839
    CTGFP292792, 3, ENSP000003569544MINT-1781238 I2D: score=1 STRING: ENSP00000356954
    SPP1P104513, ENSP000003785174I2D: score=3 STRING: ENSP00000378517
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis TAS19267251
    GO:0007044cell-substrate junction assembly IEA--
    GO:0007155cell adhesion TAS2454952
    GO:0007157heterophilic cell-cell adhesion IEA--
    GO:0007159leukocyte cell-cell adhesion IEA--

    ITGA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ITGA5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    7 Novoseek inferred chemical compound relationships for ITGA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    grgdsp 69.6 5 1701798 (1), 8509148 (1), 2365089 (1), 7648723 (1)
    tyrosine 23 3 7561105 (1), 9230816 (1), 10934648 (1)
    procollagen 18.5 2 11721465 (2)
    agarose 0 1 7782460 (1)
    thymidine 0 1 7519154 (1)
    calcium 0 1 14988150 (1)
    vegf 0 2 12844402 (1), 11715447 (1)



    ITGA5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITGA5 gene: 
    NM_002205.2  

    Unigene Cluster for ITGA5:

    Integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
    Hs.505654  [show with all ESTs]
    Unigene Representative Sequence: NM_002205
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552564 ENST00000293379(uc001sga.3 uc010sow.1 uc009znp.1)
    ENST00000547197 ENST00000549601 ENST00000552431 ENST00000552387 ENST00000552583
    ENST00000551564 ENST00000550141 ENST00000551861 ENST00000435631 ENST00000553071
    ENST00000547744
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA5 (see all 57):
    hsa-miR-194* hsa-miR-1321 hsa-miR-328 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-25 hsa-miR-128 hsa-miR-486-3p
    SwitchGear 3'UTR luciferase reporter plasmidITGA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGA5
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA5
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA5 (see all 6)
    OriGene ORF clones in mouse, rat for ITGA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA5 (NM_002205)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ITGA5
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA5
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA5
      QuantiFast Probe-based Assays in human, mouse, rat ITGA5

    Additional mRNA sequence: 

    AK291570.1 AK304696.1 AK311051.1 AK312414.1 AY429549.1 BC008786.2 M13918.2 X06256.1 

    Selected DOTS entries (see all 29):

    DT.92444607  DT.450714  DT.95243875  DT.95290467  DT.92444616  DT.121187784  DT.101985272  DT.121187844 
    DT.100717875  DT.100826365  DT.101968049  DT.121187892  DT.121187903  DT.95290161  DT.100008646  DT.121187835 
    DT.95141155  DT.95378585  DT.102833192  DT.121187837  DT.121187876  DT.121187897  DT.40123880  DT.95141150 

    Selected AceView cDNA sequences (see all 464):

    BX356797 BU541744 AA729855 CN483393 BM510584 BQ045330 BI517848 BU627164 
    N51038 BP341896 AA418731 BU542603 CA422878 BQ926389 AA588807 AA370076 
    CA306044 AL703365 BU846469 AA303865 BX397849 AW089568 AI262538 AI459715 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITGA5 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c ·
    SP1:        -     -                                                           -                                         -     -                                 
    SP2:                                                                                                                    -     -                                 
    SP3:                                                                                                                    -     -                             -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19d ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a · 32b · 32c · 32d
    SP1:                                                                    -                       -                       -                           
    SP2:                                                                                            -                       -                           
    SP3:  -     -     -                                                                                                                                 
    SP4:                                                                                            -                                                   
    SP5:                                                                                      -     -                       -                           


    ECgene alternative splicing isoforms for ITGA5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCAACAG
    ITGA5 Expression
    About this image


    ITGA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Limb (Muscoskeletal System)    fully expand to see all 6 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells (HYNR-CS inj)
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (HYNR-CS inj)
    ITGA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.505654
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA5 (see all 8): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Endothelial Cell Biology in human mouse rat
              Atherosclerosis in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ITGA5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga51 , 5 integrin alpha 5 (fibronectin receptor alpha)1, 5 87.45(n)1
    90.75(a)1
      15 (58.90 cM)5
    164021  NM_010577.31  NP_034707.31 
     1033442865 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    20(a)
    many ↔ many
    14(15101013-15111601)
    lizard
    (Anolis carolinensis)
    Reptilia ITGA56
    integrin, alpha 5 (fibronectin receptor, alpha pol...
    66(a)
    1 ↔ 1
    GL343250.1(1639533-1757915)
    African clawed frog
    (Xenopus laevis)
    Amphibia itga5-A2 integrin alpha5 subunit 76.9(n)    U12683.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570599862   -- 78(n)    57059986 
    fruit fly
    (Drosophila melanogaster)
    Insecta if3 maintenance of protein localization
    cell adhesion more
    31(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F54F2.13 Vitronectin receptor alpha subunit 30(a)
    (best of 2)
      III(8890624-8896700)   --


    ENSEMBL Gene Tree for ITGA5 (if available)
    TreeFam Gene Tree for ITGA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA5 gene
    ITGA12  ITGA62  ITGA32  ITGAE2  ITGA72  ITGAD2  ITGA82  ITGA2B2  
    ITGAV2  ITGAM2  ITGAX2  ITGA112  ITGAL2  ITGA22  ITGA92  ITGA102  
    ITGA42  
    5 SIMAP similar genes for ITGA5 using alignment to 4 protein entries:     ITA5_HUMAN (see all proteins):
    ITGAV    ITGA8    ITGA2B    ITGA9    ITGA4

    ITGA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA5 (see all 616)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450277491,2
    --54622062(+) GTGATA/TATGTA 1 -- ds50010--------
    rs1475967901,2
    C--54622215(+) ATTTTA/CTGAAC 1 -- ds50010--------
    rs1420484701,2
    --54622262(+) GCATTC/TTGCTC 1 -- ds50010--------
    rs1895789671,2
    --54622290(+) GAGAAC/GAGGTT 1 -- ds50010--------
    rs1147484021,2
    C,F--54622412(+) AGGGAG/ACCTAG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1430615431,2
    --54622437(+) TTTCTA/GGGGGG 1 -- ds50010--------
    rs1483569361,2
    --54622482(+) AGAGAA/GATAGG 1 -- ds50010--------
    rs1818778421,2
    --54622513(+) GCTTGC/GTTCCA 1 -- ds50010--------
    rs11348801,2
    C,F,H--54622659(-) TCTCTC/TTGCCC 1 -- ut31 ese34Minor allele frequency- T:0.02MN NS NA 288
    rs96531,2
    C,F,A,H--54622665(-) CCCTCA/CTCTCT 1 -- ut3114Minor allele frequency- C:0.07MN EA NS NA WA 1784

    HapMap Linkage Disequilibrium report for ITGA5 (54789045 - 54813244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ITGA5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745915CNV Deletion23290073

    Human Gene Mutation Database (HGMD): ITGA5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA5
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 135620    OMIM disorders: --

    Selected diseases for ITGA5 (see all 65):    
    About MalaCards
    gastric cardia adenocarcinoma    adenomyosis    alport syndrome    leiomyomatosis
    pertussis    shigellosis    cytomegalovirus infection    abdominal aortic aneurysm
    endometriosis    age related macular degeneration    myeloma    aortic aneurysm
    lymphoblastic leukemia    hypertrophic cardiomyopathy    endotheliitis    tonsillitis
    scleroderma    chondrosarcoma    kaposi's sarcoma    transitional cell carcinoma

    2 diseases from the University of Copenhagen DISEASES database for ITGA5:
    Myeloma     Leukemia

    ITGA5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ITGA5 gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 33.3 8 8797890 (2), 7919345 (1), 9575147 (1)
    colon carcinoma 20.7 4 8612688 (2), 9430710 (1), 11169447 (1)
    lymphoblastic leukemia acute 20 3 7768307 (1), 11750103 (1)
    melanoma 19.3 4 7779718 (1), 8006453 (1), 7657531 (1)
    hepatocellular carcinoma 16.1 5 11244970 (2), 9772498 (2), 10888226 (1)
    rheumatoid arthritis 15.9 1 8853226 (1)
    tumors 14.2 13 10794159 (2), 10730274 (1), 8830331 (1), 1386557 (1) (see all 9)
    metastasis 13.4 6 9772498 (2), 18381440 (1), 11244970 (1), 1386557 (1) (see all 5)
    leukemia 7.9 1 8350618 (1)
    metastatic melanoma 5.77 1 1386557 (1)

    Genetic Association Database (GAD): ITGA5
    Human Genome Epidemiology (HuGE) Navigator: ITGA5 (1 document)

    Export disorders for ITGA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA5 gene, integrated from 10 sources (see all 443):
    (articles sorted by number of sources associating them with ITGA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor. (PubMed id 22451694)1, 2 Nagae M.... Takagi J. (J. Cell Biol. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. (PubMed id 16051604)1, 2 Chen F.-H.... Lawler J. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. (PubMed id 14596610)1, 2 Krokhin O.V....Wilkins J.A. (Biochemistry 2003)
    6. The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. (PubMed id 10397733)1, 2 Barillari G.... Ensoli B. (Blood 1999)
    7. The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter. (PubMed id 1834647)1, 2 Birkenmeier T.M.... Dean D.C. (J. Biol. Chem. 1991)
    8. Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. (PubMed id 2454952)1, 3 Sosnoski D.M....Bennett J.S. (J. Clin. Invest. 1988)
    9. Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. (PubMed id 2450560)1, 2 Fitzgerald L.A....Phillips D.R. (Biochemistry 1987)
    10. Amino acid sequence of the human fibronectin receptor. (PubMed id 2958481)1, 2 Argraves W.S....Ruoslahti E. (J. Cell Biol. 1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3678 HGNC: 6141 AceView: ITGA5 Ensembl:ENSG00000161638 euGenes: HUgn3678
    ECgene: ITGA5 Kegg: 3678 H-InvDB: ITGA5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGA5 gene:
    Search GeneIP for patents involving ITGA5

    Licensable Technologies for ITGA5 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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