ITGA5 Gene
protein-coding GIFtS : 70 GCID: GC12 M054789
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) FNRA )
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Aliasesfor ITGA5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide) 1 2 CD49 Antigen-Like Family Member E2 3 FNRA1 2 3 5 VLA5A2 5 CD49e1 2 Fibronectin Receptor, Alpha Subunit2 Fibronectin Receptor Subunit Alpha2 3 Integrin Alpha-52 Integrin Alpha-F2 3 Very Late Activation Protein 5, Alpha Subunit2 VLA-52 3 CD49e Antigen3
Export aliases for ITGA5 gene to outside databases Previous GC identifers: GC12M054915 GC12M054505 GC12M053075 GC12M051828
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Summariesfor ITGA5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ITGA5 : The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648 Function : Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in itsligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions summary
for ITGA5 : Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist asheterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated andcontain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cellattachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes withproteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focaladhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also havea significant role in cell signaling and can activate protein kinases involved in the regulation of cellgrowth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbbeta3)is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of plateletswith fibrin, and so has a vital role in blood clot formation. Gene Wiki entry for ITGA5
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Genomic Viewsfor ITGA5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ITGA5 gene promoter:AP-2alpha isoform 3 AP-1 ATF-2 AP-2alpha isoform 2 PPAR-gamma1 PPAR-gamma2 AP-2alpha isoform 4 c-Jun AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for ITGA5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q11-q13 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q11-q13 ITGA5 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M054789: view genomic region
(about GC identifiers )
Start: 54,789,045 bp from pter End:
54,813,244 bp from pter
Size: 24,200 bases Orientation:
minus strand
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Proteinsfor ITGA5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648 See
protein sequence )Recommended Name: Size : 1049 amino acids; 114536 DaSubunit : Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linkedby a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat
Subcellular location : Membrane; Single-pass type I membrane protein2 PDB 3D structures from :3VI3 (3D) 3VI4 (3D) Secondary accessions : Q96HA5Explore the universe of human proteins at neXtProt for ITGA5: NX_P08648 Post-translational modifications:
Proteolytic cleavage by PCSK5 mediates activation of the precursor1 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P08648 ITGA5 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002196.2 ENSEMBL proteins: ENSP00000293379 ENSP00000450267 ENSP00000405865 ENSP00000447347 Reactome Protein details: P08648 Human Recombinant Protein Products: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing ITGA5 Antibody Products: Assay Products for ITGA5:
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Protein
Domains /for ITGA5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P08648 ProtoNet protein and cluster: P08648
3 Blocks protein families : IPB000413 IPB013513 IPB013517 UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648 Similarity : Belongs to the integrin alpha chain familySimilarity : Contains 7 FG-GAP repeats
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Functionfor ITGA5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ITA5_HUMAN, P08648 Function : Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in itsligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions
Genatlas biochemistry entry for ITGA5 integrin,alpha 5 component of VLA-5 receptor,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,complexing with ITGB1 in fibronectin receptor Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ITGA5 (NM_002205 ) Sino Biological Human cDNA Clone for ITGA5 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITGA5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ITGA5
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA5
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing 2 GenomeRNAi human phenotypes for ITGA5 :Animal Models: Itga5 tm2.1Hyn Itga5 tm1Hyn 8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Itga5) :About GeneDecksing
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Pathways & Interactionsfor ITGA5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/44 super-pathways (see all 44 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Cell adhesion_Integrin-mediated cell adhesion and migration 2 Integrin Pathway 3 Apoptotic Pathways in Synovial Fibroblasts 4 Axon guidance 5 Actin Nucleation by ARP-WASP Complex
Pathway sources See GeneCards unified pathways Show all pathways 5/8 (see all 8 )1 5/33 (see all 33 )2 5/8 (see all 8 )5/8 (see all 8 ) 5/12 (see all 12 )5/11 (Kegg details for ITGA5) (see all 11 ):About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA5 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/142 Interacting proteins for ITGA5 (P08648 1 , 2 , 3 ENSP00000293379 4 via UniProtKB, MINT, STRING , and/or I2D (see all 142 )About this table Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ITGA5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for ITGA5 available from Tocris Bioscience About this table Compound Action
CAS
# RGDS peptide Integrin binding sequence; inhibits integrin receptor function [91037-65-9] Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitor [154303-05-6]
7 Novoseek chemical compound relationships for ITGA5 gene About this table ITGA5 / ITA5
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Transcriptsfor ITGA5 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ITGA5 gene: NM_002205.2 Unigene Cluster for ITGA5:
Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) Hs.505654 [show with all ESTs ] Unigene Representative Sequence: NM_002205 13 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000552564 ENST00000293379 (uc001sga.3 uc010sow.1 uc009znp.1 )ENST00000547197 ENST00000549601 ENST00000552431 ENST00000552387 ENST00000552583 ENST00000551564 ENST00000550141 ENST00000551861 ENST00000435631 ENST00000553071 ENST00000547744 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ITGA5 (NM_002205 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITGA5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ITGA5
Additional cDNA sequence: AK291570.1 AK304696.1 AK311051.1 AK312414.1 AY429549.1 BC008786.2 M13918.2 X06256.1
24/29 DOTS entries (see all 29 ): DT.92444607 DT.450714
DT.95243875 DT.95290467 DT.92444616 DT.121187784 DT.101985272 DT.121187844 DT.100717875 DT.100826365 DT.101968049 DT.121187892 DT.121187903 DT.95290161 DT.100008646 DT.121187835 DT.95141155 DT.95378585 DT.102833192 DT.121187837 DT.121187876 DT.121187897 DT.40123880 DT.95141150 24/464 AceView cDNA sequences (see all 464 ):
BQ575931 AU132943 AA729855 AV654005 BQ045330 H41009 CA389046 BM511420 AI278366 AI042429 BF916470 BX397849 BU541744 BQ026801 BI517848 CD614214 AA418731 BU846469 BU687569 AI500496 BQ300772 AW193228 CA454382 AL549331 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA5 (see all 10 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b · 19c · SP1 : - - - - - SP2 : - - SP3 : - - - SP4 : SP5 :
ExUns: 19d ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30a · 30b ^ 31a · 31b · 31c ^ 32a · 32b · 32c · 32d SP1 : - - - SP2 : - - SP3 : - - - SP4 : - SP5 : - - -
ECgene alternative splicing isoforms for ITGA5
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Expression for ITGA5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ITGA5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATGGCAACAG
About this image ITGA5 expression in embryonic tissues and stem cells About this table See ITGA5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ITGA5 SOURCE GeneReport for Unigene cluster: Hs.505654 SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA5 (see all 8 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA5
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Orthologsfor ITGA5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ITGA5 gene from 5/18 species (see all 18 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
lizard Reptilia ----
--
72(a) 54(a)
1 ↔ many1 ↔ many
GL343250.1(1685961-1736878) GL343250.1(1739464-1752370)
African clawed frog Amphibia itga5-A2
integrin alpha5 subunit
76.9(n)
U12683.1
zebrafish Actinopterygii 570599862
--
78(n)
57059986
fruit fly Insecta if3
maintenance of protein localization cellmore
31(a)
--
worm Secernentea F54F2.13
Vitronectin receptor alpha subunit
30(a)
III(8890624-8896700) --
ENSEMBL Gene Tree for ITGA5 (if available)TreeFam Gene Tree for ITGA5 (if available)
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Paralogsfor ITGA5 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ITGA5 gene ITGA1 2 ITGA6 2 ITGA3 2 ITGA7 2 ITGA8 2 ITGAM 2 ITGA11 2 ITGA2 2 ITGAE 2 ITGAD 2 ITGA2B 2 ITGAV 2 ITGAX 2 ITGAL 2 ITGA9 2 ITGA4 2 ITGA10 2 5 SIMAP similar genes for ITGA5 using alignment to 4 protein entries: ITA5_HUMAN (see all proteins ):ITGAV ITGA8 ITGA2B ITGA9 ITGA4 About GeneDecksing
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Genomic Variantsfor ITGA5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 12 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for ITGA5 (54789045 - 54813244 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ITGA5: -- Human Gene Mutation Database (HGMD) : ITGA5 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor ITGA5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 135620
OMIM disorders : --20/63 (see all 63 ): About MalaCards age related macular degeneration abdominal aortic aneurysm blood clots aortic aneurysm macular degeneration lymphoblastic leukemia alport syndrome cytomegalovirus infection inflammatory bowel disease transitional cell carcinoma leiomyomatosis acute lymphoblastic leukemia rheumatoid arthritis fanconi's anemia ulcerative colitis kaposi's sarcoma squamous cell carcinoma adenomyosis colon carcinoma multiple myeloma 1 disease from the University of Copenhagen DISEASES database for ITGA5 :Myeloma 10/13 Novoseek disease relationships for ITGA5 gene (see all 13 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
myeloma
33.3
8
8797890 (2), 7919345 (1), 9575147 (1)
colon carcinoma
20.7
4
8612688 (2), 9430710 (1), 11169447 (1)
lymphoblastic leukemia acute
20
3
7768307 (1), 11750103 (1)
melanoma
19.3
4
7779718 (1), 8006453 (1), 7657531 (1)
hepatocellular carcinoma
16.1
5
11244970 (2), 9772498 (2), 10888226 (1)
rheumatoid arthritis
15.9
1
8853226 (1)
tumors
14.2
13
10794159 (2), 10730274 (1), 8830331 (1), 1386557 (1) (see all 9 )
metastasis
13.4
6
9772498 (2), 18381440 (1), 11244970 (1), 1386557 (1) (see all 5 )
leukemia
7.9
1
8350618 (1)
metastatic melanoma
5.77
1
1386557 (1)
Human Genome Epidemiology (HuGE) Navigator: ITGA5 (1 document)Export disorders for ITGA5 gene to outside databases
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Publicationsfor ITGA5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ITGA5 gene, integrated from 9 sources (see all 421 ):(articles sorted by number of sources associating them with ITGA5) Utopia : connect your pdf to the dynamic
Crystal structure of a5b1 integrin ectodomain: atomic details of the fibronectin receptor. (PubMed id 22451694) 1 , 2 (2012) Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. (PubMed id 16051604) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. (PubMed id 14596610) 1 , 2 (2003) The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. (PubMed id 10397733) 1 , 2 (1999) The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter. (PubMed id 1834647) 1 , 2 (1991) Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa. (PubMed id 2454952) 1 , 3(1988) Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. (PubMed id 2450560) 1 , 2 (1987) Amino acid sequence of the human fibronectin receptor. (PubMed id 2958481) 1 , 2 (1987) The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. (PubMed id 3033641) 1 , 2 (1987)
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External Searches for ITGA5 gene
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Genome Databases showing ITGA5 gene
(According to
Entrez Gene ,
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Specialized Databases showing ITGA5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for ITGA5 gene: ITGA5 Licensable Technologies for ITGA5 gene: GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ITGA5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for ITGA5 OriGene shRNA RFP for ITGA5 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for ITGA5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ITGA5 OriGene 3'-UTR Clone for ITGA5 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for ITGA5 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ITGA5 OriGene Custom Protein Services for ITGA5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGA5 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for ITGA5
Tocris compounds for ITGA5
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA5
ThermoFisher Antibody for ITGA5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ITGA5
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summary
for 
and Proteopedia 
for ITGA5:
BioSystems Pathways for ITGA5 (
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Selective marker
Microarrays
In-situ hybridization
