Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA4 Gene

protein-coding   GIFtS: 72
GCID: GC02P182285

Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4...


(Previous symbol: CD49D)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4
Receptor)1 2
     Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor2
CD49D1 2 3 5     Integrin Alpha 42
Integrin Alpha-IV2 3     Integrin Alpha-42
CD49 Antigen-Like Family Member D2 3     Integrin Alpha-4 Subunit2
VLA-4 Subunit Alpha2 3     Very Late Activation Protein 4 Receptor, Alpha 4 Subunit2
269C Wild Type2     CD49d Antigen3
IA42     

External Ids:    HGNC: 61401   Entrez Gene: 36762   Ensembl: ENSG000001152327   OMIM: 1929755   UniProtKB: P136123   

Export aliases for ITGA4 gene to outside databases

Previous GC identifers: GC02P180528 GC02P181004 GC02P182524 GC02P182525 GC02P182146 GC02P182029 GC02P174178


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA4 Gene:
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric
integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain.
Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked
cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA4 Gene: 
ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)) is a protein-coding gene. Diseases associated with ITGA4 include venous insufficiency, and pediatric multiple sclerosis, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include fibronectin binding and metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612
Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or
more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for
VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a
receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4
triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic
T-cell interactions with target cells

summary for ITGA4 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA4 (CD49d) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA4 gene promoter:
         STAT1   STAT1beta   STAT1alpha   CREB   IRF-2   POU2F1   Ik-2   deltaCREB   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.3   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31-q32

ITGA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P182285:  view genomic region     (about GC identifiers)

Start:
182,321,619 bp from pter      End:
182,402,474 bp from pter
Size:
80,856 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612 (See protein sequence)
Recommended Name: Integrin alpha-4 precursor  
Size: 1032 amino acids; 114900 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two
non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN,
LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAB59613.1; Type=Frameshift; Positions=13; Sequence=CAA34852.1; Type=Frameshift;
Positions=13;
2 PDB 3D structures from and Proteopedia for ITGA4:
3V4P (3D)        3V4V (3D)    
Secondary accessions: D3DPG4

Explore the universe of human proteins at neXtProt for ITGA4: NX_P13612

Explore proteomics data for ITGA4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation on Ser-1027 inhibits PXN binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13612

  • ITGA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA4 Protein Expression
    REFSEQ proteins: NP_000876.3  
    ENSEMBL proteins: 
     ENSP00000340149   ENSP00000380227   ENSP00000233573  
    Reactome Protein details: P13612
    Human Recombinant Protein Products for ITGA4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA4 (Integrin alpha 4 beta 1, Integrin alpha 4 beta 7/LPAM-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA4
    OriGene Protein Over-expression Lysate for ITGA4
    OriGene MassSpec for ITGA4 
    OriGene Custom Protein Services for ITGA4
    GenScript Custom Purified and Recombinant Proteins Services for ITGA4
    Novus Biologicals ITGA4 Proteins
    Novus Biologicals ITGA4 Lysate
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for ITGA4 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface IDA1715889
    GO:0070062extracellular vesicular exosome IDA12519789

    ITGA4 for ontologies           About GeneDecksing



    ITGA4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA4
    R&D Systems Antibodies for ITGA4 (Integrin alpha 4/CD49d)
    Cell Signaling Technology (CST) Antibodies for ITGA4 
    OriGene Antibodies for ITGA4
    OriGene Custom Antibody Services for ITGA4
    GenScript Custom Superior Antibodies Services for ITGA4
    Novus Biologicals ITGA4 Antibodies
    Abcam antibodies for ITGA4
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for ITGA4
    LSBio Antibodies in human, mouse, rat for ITGA4 

    Assay Products for ITGA4: 
    EMD Millipore Kits and Assays for the Analysis of ITGA4
    OriGene Custom Assay Services for ITGA4
    R&D Systems Proteome Profiler Antibody Arrays for ITGA4 (Integrin alpha 4/CD49d)
    GenScript Custom Assay Services for ITGA4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P13612

    ProtoNet protein and cluster: P13612

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612
    Domain: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA4_HUMAN, P13612
    Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or
    more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for
    VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a
    receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4
    triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic
    T-cell interactions with target cells

         Genatlas biochemistry entry for ITGA4:
    integrin,alpha 4,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,component of VLA-4 receptor,dimerizing with ITGB1 or ITGB7 in fibronectin,VCAM1 receptors

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI10604475
    GO:0046872metal ion binding IEA--
         
    ITGA4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ITGA4:
     Decreased Salmonella-containin  Large nuclei 

         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Itga4):
     cardiovascular system  cellular  craniofacial  embryogenesis  hematopoietic system 
     immune system  mortality/aging 

    ITGA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itga4tm1Hyn for ITGA4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA4
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA4 (see all 35):
    hsa-miR-106a hsa-miR-301a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidITGA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA4
    Sirion Biotech Customized adenovirus for overexpression of ITGA4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGA4 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA4 (NM_000885)
    Sino Biological Human cDNA Clone for ITGA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA4 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA4
    Search LifeMap BioReagents cell lines for ITGA4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA4 About   (see all 36)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ITGA4
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Role of integrins in NK cells cytotoxicity

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA4 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ITGA4
        Adhesion

    2 Tocris Bioscience Pathways for ITGA4
        NF-kappaB Pathway
    MAPK Pathway

    2 GeneGo (Thomson Reuters) Pathways for ITGA4
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Role of integrins in NK cells cytotoxicity

    5/6 BioSystems Pathways for ITGA4 (see all 6)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Paxillin-dependent events mediated by a4b1
    a4b1 and a4b7 Integrin signaling


    5/7        Reactome Pathways for ITGA4 (see all 7)
        Hemostasis
    Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Signal Transduction
    Adaptive Immune System


    5/12         Kegg Pathways  (Kegg details for ITGA4) (see all 12):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage


    ITGA4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for ITGA4 (P136121, 2, 3 ENSP000003802274) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055561, 3, ENSP000003640944EBI-703044,EBI-703066 I2D: score=2 STRING: ENSP00000364094
    PXNP490231, 3, ENSP000002283074EBI-703044,EBI-702209 I2D: score=3 STRING: ENSP00000228307
    YWHAZP631042, 3, ENSP000003095034MINT-8008939 I2D: score=1 STRING: ENSP00000309503
    TGFB1I1O432941, 3, ENSP000003783324EBI-703044,EBI-1051449 I2D: score=2 STRING: ENSP00000378332
    EEDO755303, ENSP000002633604I2D: score=4 STRING: ENSP00000263360
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling IEA--
    GO:0007155cell adhesion ----
    GO:0007157heterophilic cell-cell adhesion IEA--
    GO:0007159leukocyte cell-cell adhesion IDA1715889
    GO:0007229integrin-mediated signaling pathway IEA--

    ITGA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ITGA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    2 DrugBank Compounds for ITGA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NatalizumabAnti-alpha4 integrin (see all 2)189261-10-7targetantibody16268663 11752352 17461891 16634035 9389694
    Tinzaparin-- 9041-08-1targetinhibitor19888514

    10/50 Novoseek inferred chemical compound relationships for ITGA4 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    natalizumab 91.7 102 19188571 (4), 20453514 (4), 19283860 (3), 19278014 (3) (see all 60)
    slex 69 21 9430509 (3), 8547121 (1), 12580864 (1), 16689823 (1) (see all 15)
    slea 63 5 9430509 (3), 9733622 (1)
    elan 54.3 3 15851719 (1), 16848686 (1), 14758775 (1)
    alpha e 43 1 9683663 (1)
    rantes 39.5 5 18700028 (2), 8855287 (1), 7542307 (1), 9155832 (1)
    rgd peptide 37.5 1 8260708 (1)
    grgdsp 37.3 2 1701798 (1)
    fmlp 32 3 15242880 (1), 14525968 (1)
    cytochalasin d 27.1 1 11274763 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGA4 / ITA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA4 gene: 
    NM_000885.4  

    Unigene Cluster for ITGA4:

    Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    Hs.440955  [show with all ESTs]
    Unigene Representative Sequence: NM_000885
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476089 ENST00000339307 ENST00000397033(uc002unu.3 uc002unv.3)
    ENST00000465522(uc010zfl.1) ENST00000233573 ENST00000484404 ENST00000478440
    ENST00000473002 ENST00000490435 ENST00000476824(uc010frj.1) ENST00000468948

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA4
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA4 (see all 35):
    hsa-miR-106a hsa-miR-301a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidITGA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA4
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA4 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA4 (NM_000885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA4 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGA4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA4

    Additional mRNA sequence: 

    AB208885.1 AJ504733.1 AJ508356.1 AJ510246.1 AJ510247.1 AJ510248.1 AJ510249.1 AK124630.1 
    AK303220.1 AK303478.1 AK310610.1 AK311738.1 BC016671.2 BC055419.1 BC080190.1 L12002.1 
    X16983.1 

    12 DOTS entries:

    DT.97840348  DT.112809  DT.100757359  DT.100687935  DT.92423249  DT.203154  DT.75151267  DT.91996310 
    DT.92423246  DT.92423248  DT.100650668  DT.120966512 

    24/142 AceView cDNA sequences (see all 142):

    AW770102 AW207267 BG389093 AL135563 CR608570 CR618530 CR608655 BU729877 
    AJ510246 AI611787 AA768667 AW499866 CR618928 AI363371 BX492953 AW518281 
    AJ713338 CB528856 BQ024633 AA780167 AA490846 AI393378 BC016671 AA908980 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
    SP1:                                      -                 -           -                                   -                                   -               
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:                                      -                 -           -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:              -                                                                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ITGA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA4 expression in normal human tissues (normalized intensities)      ITGA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTAAAA
    ITGA4 Expression
    About this image


    ITGA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 5 entries
             Monocytes Peripheral Blood
             Umbilical cord blood-derived hematopoietic stem cells
             nk cells   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Epicardial Progenitors Cells Epicardium
             mouse/organ system/cardiovascular system   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Bud
             limb/hindlimb   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
             Seminiferous Tubules
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
             Adipose-derived stromal cells

    See ITGA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA4

    SOURCE GeneReport for Unigene cluster: Hs.440955
        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA4 (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITGA4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGA4 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga41 , 5 integrin alpha 41, 5 84.21(n)1
    84.88(a)1
      2 (47.38 cM)5
    164011  NM_010576.31  NP_034706.31 
     792554265 
    chicken
    (Gallus gallus)
    Aves ITGA41 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of more 69.43(n)
    62.07(a)
      424121  XM_421974.3  XP_421974.3 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA46
    integrin, alpha 4 (antigen CD49D, alpha 4 subunit ...
    61(a)
    1 ↔ 1
    GL343455.1(592230-641495)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978392 integrin alpha 4 76.84(n)    U54497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003313331 integrin alpha-4-like 60.14(n)
    56.17(a)
      100331333  XM_002663413.2  XP_002663459.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta scb3 calcium-dependent cell-matrix adhesion
    cell adhesion more
    27(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for ITGA4 (if available)
    TreeFam Gene Tree for ITGA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA4 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  
    ITGA102  
    8 SIMAP similar genes for ITGA4 using alignment to 6 protein entries:     ITA4_HUMAN (see all proteins):
    IA4    ITGA9    ITGA3    ITGA2B    ITGAV    ITGA5
    ITGA6    ITGA7 variant protein

    ITGA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2060 SNPs in ITGA4 are shown (see all 2060)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38359611,2
    C--181781860(-) GAGAC-/AT/TA 
            
    AAACA
    1 -- int11NA 2
    rs1113866651,2
    C,F--182319660(+) TTTTTT/ATAAAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1898282411,2
    --182319669(+) AGCAAC/TATGAA 1 -- us2k10--------
    rs1440912851,2
    --182319692(+) CCTGCC/TAACAT 1 -- us2k10--------
    rs1810148011,2
    --182319707(+) AAAAGC/TGAGCT 1 -- us2k10--------
    rs1145174041,2
    F--182319753(+) CTAACG/TTGAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1153030371,2
    C,F--182319757(+) CGTGAG/AGTAAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1856384301,2
    --182319825(+) AAAGTC/GCTGCC 1 -- us2k10--------
    rs1551381,2
    C,F,H--182319878(-) ATTCGT/GTTCAT 1 -- us2k115Minor allele frequency- G:0.05NS EA NA WA 1952
    rs1486956711,2
    --182319879(+) TGAAAC/TGAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGA4 (182321619 - 182402474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for ITGA4 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2517753CNV Deletion19546169
    esv2721204CNV Deletion23290073
    esv2620400CNV Deletion19546169
    esv1571329CNV Deletion17803354
    esv1979132CNV Deletion18987734
    esv1005604CNV Deletion20482838
    esv3344CNV Deletion18987735
    nsv3063CNV Insertion18451855
    nsv819063CNV Loss19587683
    esv6797CNV Loss19470904


    Human Gene Mutation Database (HGMD): ITGA4
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ITGA4
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 192975    OMIM disorders: --

    20/105 diseases for ITGA4 (see all 105):    About MalaCards
    venous insufficiency    pediatric multiple sclerosis    coronary restenosis    chronic venous leg ulcers
    arteriosclerosis obliterans    hemorrhagic fever with renal syndrome    progressive multifocal leukoencephalopathy    carpal tunnel syndrome
    crescentic glomerulonephritis    allergic conjunctivitis    blood clots    allergic encephalomyelitis
    malt lymphoma    myeloma    arteriosclerosis    waldenstrom macroglobulinemia
    multiple sclerosis    macroglobulinemia    plasmacytoma    viral hepatitis

    6 diseases from the University of Copenhagen DISEASES database for ITGA4:
    Progressive multifocal leukoencephalopathy     Multiple sclerosis     Asthma     Crohn's disease
    Eosinophilia     Multiple myeloma

    ITGA4 for disorders           About GeneDecksing

    10/91 Novoseek inferred disease relationships for ITGA4 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukoencephalopathy progressive multifocal 68.6 5 20442571 (1), 16827596 (1), 16932490 (1), 15947080 (1) (see all 5)
    multiple sclerosis 64.4 35 17689671 (2), 11544011 (1), 16052610 (1), 18465535 (1) (see all 32)
    inflammation 55.9 49 11857637 (3), 16918513 (3), 9399955 (2), 9516132 (2) (see all 37)
    myeloma 50.9 49 14688392 (3), 11378537 (3), 8797890 (2), 7861616 (1) (see all 14)
    multiple sclerosis relapsing-remitting 48.5 4 20442571 (1), 19064754 (1), 18673197 (1), 18836525 (1)
    encephalomyelitis 46.6 7 9840619 (2), 7530745 (1), 8857744 (1), 10626664 (1) (see all 6)
    necrosis 44 25 1709380 (1), 7488336 (1), 9058776 (1), 19309716 (1) (see all 21)
    inflammatory bowel diseases 35.7 3 16856112 (1), 12943458 (1), 17253580 (1)
    eosinophilia 32.1 8 11408770 (5), 9399955 (1), 8906116 (1)
    demyelinating diseases 31.6 1 16268663 (1)

    Genetic Association Database (GAD): ITGA4
    Human Genome Epidemiology (HuGE) Navigator: ITGA4 (15 documents)

    Export disorders for ITGA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA4 gene, integrated from 9 sources (see all 935):
    (articles sorted by number of sources associating them with ITGA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of the alpha4 integrin subunit gene (ITGA4) with autism. (PubMed id 19259978)1, 4, 9 Correia C....Vicente A.M. (2009)
    2. ITGA4 polymorphisms and susceptibility to multiple sclerosis. (PubMed id 17689671)1, 4, 9 O'Doherty C....Vandenbroeck K. (2007)
    3. Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. (PubMed id 11533025)1, 2, 9 Han J....Ginsberg M.H. (2001)
    4. A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. (PubMed id 9488735)1, 2, 9 Iida J.... McCarthy J.B. (1998)
    5. Identification of nine novel loci associated with whi te blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (2009)
    10. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3676 HGNC: 6140 AceView: ITGA4 Ensembl:ENSG00000115232 euGenes: HUgn3676
    ECgene: ITGA4 Kegg: 3676 H-InvDB: ITGA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA4 gene:
    Search GeneIP for patents involving ITGA4

    Licensable Technologies for ITGA4 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA4
     Browse Small Molecules at EMD Millipore
     EMD Millipore Kits and Assays for the Analysis of ITGA4
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ITGA4 (Integrin alpha 4/CD49d)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for ITGA4 (Integrin alpha 4 beta 1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for ITGA4 (Integrin alpha 4/CD49d)  
     OriGene Antibodies for ITGA4   OriGene RNAi products in human, mouse, rat for ITGA4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGA4  
     OriGene MassSpec something-or-other for ITGA4   OriGene clones in human, mouse for ITGA4  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGA4   OriGene Purified Protein for ITGA4  
     OriGene ORF clones in mouse, rat for ITGA4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGA4   OriGene Custom Protein Services for ITGA4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITGA4
     QIAGEN SeqTarget long-range PCR primers for resequencing ITGA4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA4
     GenScript Custom Purified and Recombinant Proteins Services for ITGA4 GenScript cDNA clones with any tag delivered in your preferred vector for ITGA4
     GenScript Custom Assay Services for ITGA4 GenScript Custom Superior Antibodies Services for ITGA4
     GenScript Custom overexpressing Cell Line Services for ITGA4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ITGA4 

     Regulatory tfbs in ITGA4 promoter
     Search Chromatin IP Primers for ITGA4
     RT2 qPCR Primer Assay in human, mouse, rat ITGA4
     GNC Network for ITGA4
     SABiosciences PCR Arrays including human, mouse, rat ITGA4
     Tocris compounds for ITGA4
     Browse Sino Biological Proteins and Antibodies
     Cell Lysates for ITGA4
     cDNA Clones for ITGA4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ITGA4 antibodies
     ITGA4 proteins
     ITGA4 lysates
     Antibodies for ITGA4
     See all of Abcam's Antibodies, Kits and Proteins for ITGA4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ITGA4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA4
     SwitchGear 3'UTR luciferase reporter plasmids for ITGA4
     SwitchGear Promoter luciferase reporter plasmids for ITGA4
     ThermoFisher Antibody for ITGA4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA4
    Customized:
     lentivirus for stable overexpression of ITGA4
     lentivirus expression plasmids for stable overexpression of ITGA4
     adenovirus for overexpression of ITGA4
     LSBio Antibodies in human, mouse, rat for ITGA4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGA4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4