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ITGA4 Gene

protein-coding   GIFtS: 73
GCID: GC02P182285

Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4...


(Previous symbol: CD49D)
  See ITGA4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4
Receptor)1 2
     Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor2
CD49D1 2 3 5     Integrin Alpha 42
Integrin Alpha-IV2 3     Integrin Alpha-42
CD49 Antigen-Like Family Member D2 3     Integrin Alpha-4 Subunit2
VLA-4 Subunit Alpha2 3     Very Late Activation Protein 4 Receptor, Alpha 4 Subunit2
269C Wild Type2     CD49d Antigen3
IA42     

External Ids:    HGNC: 61401   Entrez Gene: 36762   Ensembl: ENSG000001152327   OMIM: 1929755   UniProtKB: P136123   

Export aliases for ITGA4 gene to outside databases

Previous GC identifers: GC02P180528 GC02P181004 GC02P182524 GC02P182525 GC02P182146 GC02P182029 GC02P174178


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA4 Gene:
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric
integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain.
Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked
cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA4 Gene:
ITGA4 (integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)) is a protein-coding gene. Diseases associated with ITGA4 include chronic venous insufficiency, and venous insufficiency. GO annotations related to this gene include fibronectin binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612
Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or
more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for
VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a
receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4
triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic
T-cell interactions with target cells

summary for ITGA4 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA4 (CD49d) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA4 gene promoter:
         STAT1   STAT1beta   STAT1alpha   CREB   IRF-2   POU2F1   Ik-2   deltaCREB   Pax-4a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGA4 promoter sequence
   Search Chromatin IP Primers for ITGA4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.3   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31-q32

ITGA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA4 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P182285:  view genomic region     (about GC identifiers)

Start:
182,321,619 bp from pter      End:
182,402,474 bp from pter
Size:
80,856 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612 (See protein sequence)
Recommended Name: Integrin alpha-4 precursor  
Size: 1032 amino acids; 114900 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two
non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN,
LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with
AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1
homodimerization
Sequence caution: Sequence=AAB59613.1; Type=Frameshift; Positions=13; Sequence=CAA34852.1; Type=Frameshift;
Positions=13;
3 PDB 3D structures from and Proteopedia for ITGA4:
3V4P (3D)        3V4V (3D)        4HKC (3D)    
Secondary accessions: D3DPG4

Explore the universe of human proteins at neXtProt for ITGA4: NX_P13612

Explore proteomics data for ITGA4 at MOPED

Post-translational modifications: 

  • Phosphorylation on Ser-1027 inhibits PXN binding1
  • Ubiquitination2 at Lys95, Lys116, Lys149, Lys190, Lys241, Lys280, Lys289, Lys363, Lys590, Lys614,
                                 Lys760, Lys771, Lys867, Lys892, Lys1028
  • Glycosylation2 at Asn79, Asn138, Asn229, Asn480, Asn518, Asn538, Asn626, Asn645, Asn660, Asn806,
                                 Asn821
  • Modification sites at PhosphoSitePlus

  • See ITGA4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000876.3  
    ENSEMBL proteins: 
     ENSP00000340149   ENSP00000380227   ENSP00000233573  
    Reactome Protein details: P13612

    ITGA4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA4 (Integrin alpha 4 beta 1, Integrin alpha 4 beta 7/LPAM-1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA4
    OriGene Protein Over-expression Lysate for ITGA4
    OriGene MassSpec for ITGA4
    OriGene Custom Protein Services for ITGA4
    GenScript Custom Purified and Recombinant Proteins Services for ITGA4
    Novus Biologicals ITGA4 Proteins
    Novus Biologicals ITGA4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA4 

     
    antibodies-online proteins for ITGA4 (2 products) 

     
    antibodies-online peptides for ITGA4

    ITGA4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA4
    R&D Systems Antibodies for ITGA4 (Integrin alpha 4/CD49d)
    Cell Signaling Technology (CST) Antibodies for ITGA4 
    OriGene Antibodies for ITGA4
    OriGene Custom Antibody Services for ITGA4
    Novus Biologicals ITGA4 Antibodies
    Abcam antibodies for ITGA4 (P05556, P13612)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ITGA4
    antibodies-online antibodies for ITGA4 (259 products) 

    ITGA4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA4
    R&D Systems Proteome Profiler Antibody Arrays for ITGA4 (Integrin alpha 4/CD49d)
    GenScript Custom Assay Services for ITGA4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGA4 
    antibodies-online kits for ITGA4 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P13612

    ProtoNet protein and cluster: P13612

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612
    Domain: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    Find genes that share domains with ITGA4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA4_HUMAN, P13612
    Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or
    more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for
    VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a
    receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4
    triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic
    T-cell interactions with target cells

         Genatlas biochemistry entry for ITGA4:
    integrin,alpha 4,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,component of VLA-4 receptor,dimerizing with ITGB1 or ITGB7 in fibronectin,VCAM1 receptors

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001968fibronectin binding IEA--
    GO:0005515protein binding IPI10604475
    GO:0046872metal ion binding IEA--
    GO:0050839cell adhesion molecule binding IPI12869515
         
    Find genes that share ontologies with ITGA4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ITGA4:
     Decreased Salmonella-containin  Large nuclei 

         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Itga4):
     cardiovascular system  cellular  craniofacial  embryogenesis  hematopoietic system 
     immune system  mortality/aging 

    Find genes that share phenotypes with ITGA4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itga4tm1Hyn for ITGA4

       genOway: Develop your customized and physiologically relevant rodent model for ITGA4

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA4:
    hsa-mir-30c-5p (MIRT007135)

    Block miRNA regulation of human, mouse, rat ITGA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA4 (see all 35):
    hsa-miR-106a hsa-miR-301a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidITGA4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA4
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA4

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA4 (see all 6)
    OriGene ORF clones in mouse, rat for ITGA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA4 (NM_000885)
    Sino Biological Human cDNA Clone for ITGA4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA4
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA4_HUMAN, P13612: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    peroxisome2
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface IDA1715889
    GO:0070062extracellular vesicular exosome IDA12519789

    Find genes that share ontologies with ITGA4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA4 About   (see all 35)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with ITGA4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA4 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ITGA4
        Adhesion

    2 Tocris Bioscience Pathways for ITGA4
        NF-kappaB Pathway
    MAPK Pathway

    2 GeneGo (Thomson Reuters) Pathways for ITGA4
        Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Immune response Role of integrins in NK cells cytotoxicity

    Selected BioSystems Pathways for ITGA4 (see all 6)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    a4b1 and a4b7 Integrin signaling
    Paxillin-independent events mediated by a4b1 and a4b7


    3 Reactome Pathways for ITGA4
        Integrin cell surface interactions
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
    Cell surface interactions at the vascular wall


    Selected Kegg Pathways  (Kegg details for ITGA4) (see all 12):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Cell adhesion molecules (CAMs)
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA4 (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA4 (P136121, 2, 3 ENSP000003802274) via UniProtKB, MINT, STRING, and/or I2D (see all 133)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055561, 3, ENSP000003640944EBI-703044,EBI-703066 I2D: score=2 STRING: ENSP00000364094
    PXNP490231, 3, ENSP000002283074EBI-703044,EBI-702209 I2D: score=3 STRING: ENSP00000228307
    YWHAZP631042, 3, ENSP000003095034MINT-8008939 I2D: score=1 STRING: ENSP00000309503
    TGFB1I1O432941, 3, ENSP000003783324EBI-703044,EBI-1051449 I2D: score=2 STRING: ENSP00000378332
    EEDO755303, ENSP000002633604I2D: score=4 STRING: ENSP00000263360
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001974blood vessel remodeling IEA--
    GO:0007155cell adhesion ----
    GO:0007157heterophilic cell-cell adhesion IEA--
    GO:0007159leukocyte cell-cell adhesion IDA1715889
    GO:0007229integrin-mediated signaling pathway IEA--

    Find genes that share ontologies with ITGA4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ITGA4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    2 DrugBank Compounds for ITGA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NatalizumabAnti-alpha4 integrin (see all 2)189261-10-7targetantibody16268663 11752352 17461891 16634035 9389694
    Tinzaparin-- 9041-08-1targetinhibitor19888514

    Selected Novoseek inferred chemical compound relationships for ITGA4 gene (see all 50)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    natalizumab 91.7 102 19188571 (4), 20453514 (4), 19283860 (3), 19278014 (3) (see all 60)
    slex 69 21 9430509 (3), 8547121 (1), 12580864 (1), 16689823 (1) (see all 15)
    slea 63 5 9430509 (3), 9733622 (1)
    elan 54.3 3 15851719 (1), 16848686 (1), 14758775 (1)
    alpha e 43 1 9683663 (1)
    rantes 39.5 5 18700028 (2), 8855287 (1), 7542307 (1), 9155832 (1)
    rgd peptide 37.5 1 8260708 (1)
    grgdsp 37.3 2 1701798 (1)
    fmlp 32 3 15242880 (1), 14525968 (1)
    cytochalasin d 27.1 1 11274763 (1)



    Find genes that share compounds with ITGA4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGA4 gene: 
    NM_000885.4  

    Unigene Cluster for ITGA4:

    Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
    Hs.440955  [show with all ESTs]
    Unigene Representative Sequence: NM_000885
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476089 ENST00000339307 ENST00000397033(uc002unu.3 uc002unv.3)
    ENST00000465522(uc010zfl.1) ENST00000233573 ENST00000484404 ENST00000478440
    ENST00000473002 ENST00000490435 ENST00000476824(uc010frj.1) ENST00000468948

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA4 (see all 35):
    hsa-miR-106a hsa-miR-301a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidITGA4 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITGA4
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA4
    Clone
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    OriGene clones in human, mouse for ITGA4 (see all 6)
    OriGene ORF clones in mouse, rat for ITGA4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA4 (NM_000885)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA4
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA4
      QuantiFast Probe-based Assays in human, mouse, rat ITGA4

    Additional mRNA sequence: 

    AB208885.1 AJ504733.1 AJ508356.1 AJ510246.1 AJ510247.1 AJ510248.1 AJ510249.1 AK124630.1 
    AK303220.1 AK303478.1 AK310610.1 AK311738.1 BC016671.2 BC055419.1 BC080190.1 L12002.1 
    X16983.1 

    12 DOTS entries:

    DT.97840348  DT.112809  DT.100757359  DT.100687935  DT.92423249  DT.203154  DT.75151267  DT.91996310 
    DT.92423246  DT.92423248  DT.100650668  DT.120966512 

    Selected AceView cDNA sequences (see all 142):

    AI363371 AJ713338 AW499866 AI708160 CR618530 BU729877 AW770102 BQ024633 
    CB528856 AA768667 CR608655 AA490846 AA780167 AA908980 BC016671 BX495101 
    AI611787 AJ510246 AI393378 CR618928 AW207267 BG389093 BX492953 AW518281 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITGA4 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
    SP1:                                      -                 -           -                                   -                                   -               
    SP2:                                                                                                                                                            
    SP3:                                      -                                                                                                                     
    SP4:                                      -                 -           -                                                                                       
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:              -                                                                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ITGA4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ITGA4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTTTAAAA
    ITGA4 Expression
    About this image


    ITGA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Epicardial Progenitors Cells Epicardium
     
     Chorion (Extraembryonic Tissues)
             Chorionic Ectoderm Cells Chorion Bilayer
     
     Placenta (Extraembryonic Tissues)
             Chorionic Ectoderm Cells Chorion Bilayer
     
     Adipose (Muscoskeletal System)    fully expand to see all 3 entries
             Body Subcutaneous White Adipose
             Adipose-derived stromal cells
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Testicular Interstitial Cells Testis Interstitium
             Seminiferous Tubules
    ITGA4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440955
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA4 (see all 6): 
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Wound Healing in human mouse rat
              Cell Junction PathwayFinder in human mouse rat
              Focal Adhesions in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA4
    QuantiTect SYBR Green Assays in human, mouse, rat ITGA4
    QuantiFast Probe-based Assays in human, mouse, rat ITGA4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ITGA4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga41 , 5 integrin alpha 41, 5 84.21(n)1
    84.88(a)1
      2 (47.38 cM)5
    164011  NM_010576.31  NP_034706.31 
     792554265 
    chicken
    (Gallus gallus)
    Aves ITGA41 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of more 69.57(n)
    62.35(a)
      424121  XM_421974.4  XP_421974.3 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA46
    integrin, alpha 4 (antigen CD49D, alpha 4 subunit ...
    62(a)
    1 ↔ 1
    GL343455.1(592230-641495)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3978392 integrin alpha 4 76.84(n)    U54497.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itga41 integrin alpha 4 60.02(n)
    56.04(a)
      100331333  XM_002663413.3  XP_002663459.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta scb3 calcium-dependent cell-matrix adhesion
    cell adhesion more
    27(a)
    (best of 3)
        --


    ENSEMBL Gene Tree for ITGA4 (if available)
    TreeFam Gene Tree for ITGA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA4 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  
    ITGA102  
    8 SIMAP similar genes for ITGA4 using alignment to 6 protein entries:     ITA4_HUMAN (see all proteins):
    IA4    ITGA9    ITGA3    ITGA2B    ITGAV    ITGA5
    ITGA6    ITGA7 variant protein

    Find genes that share paralogs with ITGA4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA4 (see all 2060)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38359611,2
    C--181781860(-) GAGAC-/AT/TA 
            
    AAACA
    1 -- int11NA 2
    rs1113866651,2
    C,F--182319660(+) TTTTTT/ATAAAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1898282411,2
    --182319669(+) AGCAAC/TATGAA 1 -- us2k10--------
    rs1440912851,2
    --182319692(+) CCTGCC/TAACAT 1 -- us2k10--------
    rs1810148011,2
    --182319707(+) AAAAGC/TGAGCT 1 -- us2k10--------
    rs1145174041,2
    F--182319753(+) CTAACG/TTGAGG 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1153030371,2
    C,F--182319757(+) CGTGAG/AGTAAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1856384301,2
    --182319825(+) AAAGTC/GCTGCC 1 -- us2k10--------
    rs1551381,2
    C,F,H--182319878(-) ATTCGT/GTTCAT 1 -- us2k115Minor allele frequency- G:0.05NS EA NA WA 1952
    rs1486956711,2
    --182319879(+) TGAAAC/TGAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITGA4 (182321619 - 182402474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGA4 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2517753CNV Deletion19546169
    esv2721204CNV Deletion23290073
    esv2620400CNV Deletion19546169
    esv1571329CNV Deletion17803354
    esv1979132CNV Deletion18987734
    esv1005604CNV Deletion20482838
    esv3344CNV Deletion18987735
    nsv3063CNV Insertion18451855
    nsv819063CNV Loss19587683
    esv6797CNV Loss19470904

    Human Gene Mutation Database (HGMD): ITGA4
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ITGA4
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192975    OMIM disorders: --

    10 diseases for ITGA4:    
    About MalaCards
    chronic venous insufficiency    venous insufficiency    breast sarcoma    pediatric multiple sclerosis
    chronic venous leg ulcers    coronary restenosis    carpal tunnel syndrome    progressive multifocal leukoencephalopathy
    myeloma    multiple sclerosis

    6 diseases from the University of Copenhagen DISEASES database for ITGA4:
    Progressive multifocal leukoencephalopathy     Multiple sclerosis     Asthma     Crohn's disease
    Eosinophilia     Multiple myeloma

    Find genes that share disorders with ITGA4           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGA4 gene (see all 91)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukoencephalopathy progressive multifocal 68.6 5 20442571 (1), 16827596 (1), 16932490 (1), 15947080 (1) (see all 5)
    multiple sclerosis 64.4 35 17689671 (2), 11544011 (1), 16052610 (1), 18465535 (1) (see all 32)
    inflammation 55.9 49 11857637 (3), 16918513 (3), 9399955 (2), 9516132 (2) (see all 37)
    myeloma 50.9 49 14688392 (3), 11378537 (3), 8797890 (2), 7861616 (1) (see all 14)
    multiple sclerosis relapsing-remitting 48.5 4 20442571 (1), 19064754 (1), 18673197 (1), 18836525 (1)
    encephalomyelitis 46.6 7 9840619 (2), 7530745 (1), 8857744 (1), 10626664 (1) (see all 6)
    necrosis 44 25 1709380 (1), 7488336 (1), 9058776 (1), 19309716 (1) (see all 21)
    inflammatory bowel diseases 35.7 3 16856112 (1), 12943458 (1), 17253580 (1)
    eosinophilia 32.1 8 11408770 (5), 9399955 (1), 8906116 (1)
    demyelinating diseases 31.6 1 16268663 (1)

    Genetic Association Database (GAD): ITGA4
    Human Genome Epidemiology (HuGE) Navigator: ITGA4 (15 documents)

    Export disorders for ITGA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA4 gene, integrated from 10 sources (see all 945):
    (articles sorted by number of sources associating them with ITGA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of the alpha4 integrin subunit gene (ITGA4) with autism. (PubMed id 19259978)1, 4, 9 Correia C....Vicente A.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    2. ITGA4 polymorphisms and susceptibility to multiple sclerosis. (PubMed id 17689671)1, 4, 9 O'Doherty C....Vandenbroeck K. (J. Neuroimmunol. 2007)
    3. Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. (PubMed id 11533025)1, 2, 9 Han J....Ginsberg M.H. (J. Biol. Chem. 2001)
    4. A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. (PubMed id 9488735)1, 2, 9 Iida J.... McCarthy J.B. (J. Biol. Chem. 1998)
    5. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. (PubMed id 21738478)1, 4 Okada Y....Kamatani N. (PLoS Genet. 2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Fine mapping and association studies in a candidate region for autism on chromosome 2q31-q32. (PubMed id 18846500)1, 4 Conroy J....Gallagher L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    10. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3676 HGNC: 6140 AceView: ITGA4 Ensembl:ENSG00000115232 euGenes: HUgn3676
    ECgene: ITGA4 Kegg: 3676 H-InvDB: ITGA4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGA4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGA4 gene:
    Search GeneIP for patents involving ITGA4

    Licensable Technologies for ITGA4 gene:
    Weizmann Institute:Enrichment of Repopulating Stem Cells For Clinical Protocols
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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