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Aliases for ITGA4 Gene

Aliases for ITGA4 Gene

  • Integrin Subunit Alpha 4 2 3 5
  • Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor) 2 3
  • Alpha 4 Subunit Of VLA-4 Receptor 2 3
  • CD49 Antigen-Like Family Member D 3 4
  • VLA-4 Subunit Alpha 3 4
  • Integrin Alpha-IV 3 4
  • Antigen CD49D 2 3
  • CD49D 3 4
  • Very Late Activation Protein 4 Receptor, Alpha 4 Subunit 3
  • Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor 3
  • Integrin Alpha-4 Subunit 3
  • Integrin Alpha 4 3
  • 269C Wild Type 3
  • CD49d Antigen 4
  • IA4 3

External Ids for ITGA4 Gene

Previous HGNC Symbols for ITGA4 Gene

  • CD49D

Previous GeneCards Identifiers for ITGA4 Gene

  • GC02P180528
  • GC02P181004
  • GC02P182285
  • GC02P182524
  • GC02P182525
  • GC02P182146
  • GC02P182029
  • GC02P174178

Summaries for ITGA4 Gene

Entrez Gene Summary for ITGA4 Gene

  • The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

GeneCards Summary for ITGA4 Gene

ITGA4 (Integrin Subunit Alpha 4) is a Protein Coding gene. Diseases associated with ITGA4 include progressive multifocal leukoencephalopathy and breast sarcoma. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include cell adhesion molecule binding and fibronectin binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA4 Gene

  • Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Tocris Summary for ITGA4 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. Under physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding.

Gene Wiki entry for ITGA4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA4 Gene

Genomics for ITGA4 Gene

Regulatory Elements for ITGA4 Gene

Genomic Location for ITGA4 Gene

Chromosome:
2
Start:
181,456,892 bp from pter
End:
181,537,747 bp from pter
Size:
80,856 bases
Orientation:
Plus strand

Genomic View for ITGA4 Gene

Genes around ITGA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA4 Gene

Proteins for ITGA4 Gene

  • Protein details for ITGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13612-ITA4_HUMAN
    Recommended name:
    Integrin alpha-4
    Protein Accession:
    P13612
    Secondary Accessions:
    • D3DPG4
    • Q7Z4L6

    Protein attributes for ITGA4 Gene

    Size:
    1032 amino acids
    Molecular mass:
    114900 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.
    SequenceCaution:
    • Sequence=AAB59613.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305}; Sequence=CAA34852.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ITGA4 Gene

    Alternative splice isoforms for ITGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA4 Gene

Proteomics data for ITGA4 Gene at MOPED

Post-translational modifications for ITGA4 Gene

  • Phosphorylation on Ser-1027 inhibits PXN binding.
  • Ubiquitination at Lys 95, Lys 116, Lys 149, Lys 190, Lys 241, Lys 280, Lys 289, Lys 363, Lys 590, Lys 614, Lys 760, Lys 771, Lys 867, Lys 892, and Lys 1028
  • Glycosylation at Asn 79, Asn 138, Asn 229, Asn 480, Asn 518, Asn 538, Asn 626, Asn 645, Asn 660, Asn 806, and Asn 821
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA4 Gene

Antibody Products

  • R&D Systems Antibodies for ITGA4 (Integrin alpha 4/CD49d)
  • Cell Signaling Technology (CST) Antibodies for ITGA4 (ITGA4)

No data available for DME Specific Peptides for ITGA4 Gene

Domains & Families for ITGA4 Gene

Gene Families for ITGA4 Gene

Suggested Antigen Peptide Sequences for ITGA4 Gene

Graphical View of Domain Structure for InterPro Entry

P13612

UniProtKB/Swiss-Prot:

ITA4_HUMAN :
  • The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA4: view

Function for ITGA4 Gene

Molecular function for ITGA4 Gene

GENATLAS Biochemistry:
integrin,alpha 4,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,component of VLA-4 receptor,dimerizing with ITGB1 or ITGB7 in fibronectin,VCAM1 receptors
UniProtKB/Swiss-Prot Function:
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Gene Ontology (GO) - Molecular Function for ITGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA --
GO:0015026 coreceptor activity TAS 23125415
GO:0050839 cell adhesion molecule binding IEA,IPI 12869515
genes like me logo Genes that share ontologies with ITGA4: view
genes like me logo Genes that share phenotypes with ITGA4: view

Animal Models for ITGA4 Gene

MGI Knock Outs for ITGA4:

Animal Model Products

  • Taconic Biosciences Mouse Models for ITGA4

miRNA for ITGA4 Gene

miRTarBase miRNAs that target ITGA4

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA4 Gene

Localization for ITGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA4 Gene COMPARTMENTS Subcellular localization image for ITGA4 gene
Compartment Confidence
extracellular 5
plasma membrane 5
peroxisome 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for ITGA4 Gene

Pathways & Interactions for ITGA4 Gene

genes like me logo Genes that share pathways with ITGA4: view

SIGNOR curated interactions for ITGA4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion IMP 18308860
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007596 blood coagulation TAS --
GO:0030183 B cell differentiation IC 1715889
genes like me logo Genes that share ontologies with ITGA4: view

Drugs & Compounds for ITGA4 Gene

(31) Drugs for ITGA4 Gene - From: Novoseek, DGIdb, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Natalizumab Approved, Investigational Pharma antibody, Target 93
Vedolizumab Approved Pharma Target, antibody 37
Tinzaparin Approved Pharma Target, inhibitor 37
ATL1102 Investigational Pharma antisense, Target 0
R1295 Investigational Pharma antagonist, Target 0

(33) Additional Compounds for ITGA4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Echistatin, alpha1 isoform
154303-05-6
GR 144053 trihydrochloride
1215333-48-4
Leukadherin 1
344897-95-6

(5) Tocris Compounds for ITGA4 Gene

Compound Action Cas Number
A 205804 Selective inhibitor of E-selectin and ICAM-1 expression 251992-66-2
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
GR 144053 trihydrochloride Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic 1215333-48-4
Leukadherin 1 Allosteric activator of CD11b/CD18 344897-95-6
MNS Selective inhibitor of Src and Syk 1485-00-3

(1) ApexBio Compounds for ITGA4 Gene

Compound Action Cas Number
RGD (Arg-Gly-Asp) Peptides Inhibits integrin binding to RGD motifs 99896-85-2
genes like me logo Genes that share compounds with ITGA4: view

Transcripts for ITGA4 Gene

Unigene Clusters for ITGA4 Gene

Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
SP1: - - - - -
SP2:
SP3: -
SP4: - - -
SP5:
SP6: - - -
SP7:
SP8:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ITGA4 Gene

GeneLoc Exon Structure for
ITGA4
ECgene alternative splicing isoforms for
ITGA4

Expression for ITGA4 Gene

mRNA expression in normal human tissues for ITGA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA4 Gene

This gene is overexpressed in Whole Blood (x5.9).

Protein differential expression in normal tissues from HIPED for ITGA4 Gene

This gene is overexpressed in Lymph node (17.2), CD8 Tcells (13.8), Peripheral blood mononuclear cells (9.3), and Spleen (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA4 Gene



SOURCE GeneReport for Unigene cluster for ITGA4 Gene Hs.440955

genes like me logo Genes that share expression patterns with ITGA4: view

Protein tissue co-expression partners for ITGA4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ITGA4 Gene

Orthologs for ITGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGA4 35
  • 87.47 (n)
  • 85.76 (a)
ITGA4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA4 35
  • 87.99 (n)
  • 87.89 (a)
ITGA4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga4 35
  • 84.21 (n)
  • 84.88 (a)
Itga4 16
Itga4 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGA4 35
  • 99.35 (n)
  • 99.42 (a)
ITGA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga4 35
  • 84.5 (n)
  • 84.5 (a)
oppossum
(Monodelphis domestica)
Mammalia ITGA4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA4 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA4 35
  • 69.57 (n)
  • 62.35 (a)
ITGA4 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA4 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga4 35
  • 63.04 (n)
  • 55.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397839 35
zebrafish
(Danio rerio)
Actinopterygii itga4 35
  • 60.02 (n)
  • 56.04 (a)
itga4 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alphaPS4 37
  • 24 (a)
alphaPS5 37
  • 26 (a)
scb 37
  • 27 (a)
alphaPS4 36
  • 21 (a)
ManyToMany
alphaPS5 36
  • 23 (a)
ManyToMany
scb 36
  • 22 (a)
ManyToMany
Species with no ortholog for ITGA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA4 Gene

ENSEMBL:
Gene Tree for ITGA4 (if available)
TreeFam:
Gene Tree for ITGA4 (if available)

Paralogs for ITGA4 Gene

(8) SIMAP similar genes for ITGA4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ITGA4: view

Variants for ITGA4 Gene

Sequence variations from dbSNP and Humsavar for ITGA4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1143676 - 181,530,618(+) AGTCC(A/G)GTTCT reference, missense
rs35322532 - 181,511,753(-) TGCAG(A/T)AACCT reference, missense
rs1143675 - 181,529,581(+) TAGTG(C/T)GGAAA reference, missense
rs149724 -- 181,494,438(+) CCCCA(C/T)CTCTA intron-variant
rs149725 -- 181,460,749(+) TCTGT(A/G)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA4 Gene

Variant ID Type Subtype PubMed ID
nsv834476 CNV Gain 17160897
nsv3063 CNV Insertion 18451855
nsv819894 CNV Loss 19587683
esv2620400 CNV Deletion 19546169
esv1979132 CNV Deletion 18987734
esv3344 CNV Deletion 18987735
esv2721204 CNV Deletion 23290073
esv2517753 CNV Deletion 19546169
esv6797 CNV Loss 19470904
esv1005604 CNV Deletion 20482838
esv1571329 CNV Deletion 17803354
nsv819063 CNV Loss 19587683

Variation tolerance for ITGA4 Gene

Residual Variation Intolerance Score: 5.69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 59.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA4 Gene

HapMap Linkage Disequilibrium report
ITGA4
Human Gene Mutation Database (HGMD)
ITGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA4 Gene

Disorders for ITGA4 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ITGA4 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ITGA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITGA4

Genetic Association Database (GAD)
ITGA4
Human Genome Epidemiology (HuGE) Navigator
ITGA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGA4
genes like me logo Genes that share disorders with ITGA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA4 Gene

Publications for ITGA4 Gene

  1. Association of the alpha4 integrin subunit gene (ITGA4) with autism. (PMID: 19259978) Correia C. … Vicente A.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 48 67
  2. Aberrant DNA methylation of integrin alpha4: a potential novel role for metastasis of cholangiocarcinoma. (PMID: 19655168) Uhm K.O. … Park S.H. (J. Cancer Res. Clin. Oncol. 2010) 3 23
  3. Co-engagement of alpha(4)beta(1) integrin (VLA-4) and CD4 or CD8 is necessary to induce maximal Erk1/2 phosphorylation and cytokine production in human T cells. (PMID: 19815047) Kim T.K. … Komanduri K.V. (Hum. Immunol. 2010) 3 23
  4. Apoptotic death of hematopoietic tumor cells through potentiated and sustained adhesion to fibronectin via VLA-4. (PMID: 20007695) Saito Y. … Fukai F. (J. Biol. Chem. 2010) 3 23
  5. Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma. (PMID: 18850009) Noborio-Hatano K. … Ozawa K. (Oncogene 2009) 3 23

Products for ITGA4 Gene

Sources for ITGA4 Gene

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