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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGA4 Gene

protein-coding GIFtS: 72
GCID: GC02P182285

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4...

(Previous symbol: CD49D)

Explore 115 diseases affiliated with
ITGA4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor)¹ ²		IA4²
CD49D¹ ² ³ ⁵		Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor²
Integrin Alpha-IV² ³		Integrin Alpha 4²
CD49 Antigen-Like Family Member D² ³		Integrin Alpha-4²
VLA-4 Subunit Alpha² ³		Integrin Alpha-4 Subunit²
CD49d¹		Very Late Activation Protein 4 Receptor, Alpha 4 Subunit²
269C Wild Type²		CD49d Antigen³

External Ids:	HGNC: 6140¹	Entrez Gene: 3676²	Ensembl: ENSG00000115232⁷	OMIM: 192975⁵	UniProtKB: P13612³

Export aliases for ITGA4 gene to outside databases

Previous GC identifers: GC02P180528 GC02P181004 GC02P182524 GC02P182525 GC02P182146 GC02P182029 GC02P174178

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA4:

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral

membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other

integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain

associates with either beta 1 chain or beta 7 chain. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612

Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more

domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1.

Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for

MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic

aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions

with target cells

summary for ITGA4:

Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as

heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and

contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell

attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,

-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with

proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal

adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have

a significant role in cell signaling and can activate protein kinases involved in the regulation of cell

growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbbeta3)

is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets

with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA4 (CD49d)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGA4 gene promoter:
STAT1 STAT1beta STAT1alpha CREB IRF-2 POU2F1 Ik-2 deltaCREB Pax-4a RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ITGA4 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGA4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.3 Ensembl cytogenetic band: 2q31.3 HGNC cytogenetic band: 2q31-q32

ITGA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA4 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P182285: view genomic region (about GC identifiers)

Start:	182,321,619 bp from pter	End:	182,402,474 bp from pter
Size:	80,856 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612 (See protein sequence)

Recommended Name: Integrin alpha-4 precursor

Size: 1032 amino acids; 114900 Da

Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently

associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and

TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan

Subcellular location: Membrane; Single-pass type I membrane protein

Sequence caution: Sequence=AAB59613.1; Type=Frameshift; Positions=13; Sequence=CAA34852.1; Type=Frameshift;

Positions=13;

2 PDB 3D structures from and Proteopedia for ITGA4:

3V4P (3D)

3V4V (3D)

Secondary accessions: D3DPG4

Explore the universe of human proteins at neXtProt for ITGA4: NX_P13612

Post-translational modifications:

Phosphorylation on Ser-1027 inhibits PXN binding¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13612

ITGA4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000876.3

ENSEMBL proteins:

ENSP00000340149 ENSP00000380227 ENSP00000233573

Reactome Protein details: P13612
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ITGA4 (Integrin alpha 4 beta 1, Integrin alpha 4 beta 7/LPAM-1)
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	Novus Biologicals ITGA4 Proteins Novus Biologicals ITGA4 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	IDA	1715889

ITGA4 for ontologies About GeneDecksing

ITGA4 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA4
	R&D Systems Antibodies for ITGA4 (Integrin alpha 4/CD49d)
	Cell Signaling Technology (CST) Antibodies for ITGA4
	OriGene Antibodies (see all 5): ITGA4 OriGene Custom Antibody Services for ITGA4
	GenScript Custom Superior Antibodies Services for ITGA4
	Novus Biologicals ITGA4 Antibodies
	Abcam antibodies for ITGA4
	Browse Antibodies at Uscn
	ThermoFisher Antibody for ITGA4

Assay Products for ITGA4:

	EMD Millipore Kits and Assays for the Analysis of ITGA4
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for ITGA4 (Integrin alpha 4/CD49d)
	GenScript Custom Assay Services for ITGA4
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGA4 for domains About GeneDecksing

5 InterPro domains/families:

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P13612

ProtoNet protein and cluster: P13612

3 Blocks protein families:

IPB000413 Integrins alpha chain

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612

Domain: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITA4_HUMAN, P13612

Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more

domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1.

Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for

MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic

aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions

with target cells

Genatlas biochemistry entry for ITGA4:

integrin,alpha 4,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,component of VLA-4 receptor,dimerizing with ITGB1 or ITGB7 in fibronectin,VCAM1 receptors

miRNA Products:		OriGene 3'-UTR Clone: ITGA4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA4
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA4 (see all 35):
		hsa-miR-106a hsa-miR-301a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: ITGA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA4 (see all 7) OriGene shRNA RFP: ITGA4 OriGene siRNA: ITGA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGA4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGA4 (NM_000885)
		Sino Biological Human cDNA Clone for ITGA4
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGA4
		Search LifeMap BioReagents cell lines for ITGA4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA4

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001968	fibronectin binding	IEA	--
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	IPI	--
GO:0046872	metal ion binding	IEA	--

ITGA4 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for ITGA4:

Decreased Salmonella-containin

Large nuclei

Animal Models:
Mouse knock-out Itga4^tm1Hyn for ITGA4
7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Itga4):

cardiovascular system	cellular	craniofacial	embryogenesis	hematopoietic system
immune system	mortality/aging

ITGA4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

Focal Adhesion

	Focal Adhesion	1.00			Integrin-mediated cell adhesion	0.38
	Focal adhesion	0.66			HGF Pathway	0.24

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ITGA4

	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Role of integrins in NK cells cytotoxicity

5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA4 (see all 33)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

1 Cell Signaling Technology (CST) Pathway for ITGA4

Adhesion

2 Tocris Bioscience Pathways for ITGA4

	NF-kappaB Pathway
	MAPK Pathway

2 GeneGo (Thomson Reuters) Pathways for ITGA4

	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Immune response Role of integrins in NK cells cytotoxicity

5/6 BioSystems Pathways for ITGA4 (see all 6)

	Integrin-mediated cell adhesion
	Focal Adhesion
	Arrhythmogenic right ventricular cardiomyopathy
	a4b1 and a4b7 Integrin signaling
	Paxillin-dependent events mediated by a4b1

5/7 Reactome Pathways for ITGA4 (see all 7)

	Hemostasis
	Integrin cell surface interactions
	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
	Signal Transduction
	Adaptive Immune System

5/11 Kegg Pathways (Kegg details for ITGA4) (see all 11):

	Focal adhesion
	ECM-receptor interaction
	Cell adhesion molecules (CAMs)
	Hematopoietic cell lineage
	Leukocyte transendothelial migration

ITGA4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGA4

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/132 Interacting proteins for ITGA4 (P13612^{1, 2, 3} ENSP00000380227⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB1	P05556¹^,³, ENSP00000364094⁴	EBI-703044,EBI-4289597 I2D: score=2 STRING: ENSP00000364094
PXN	P49023¹^,³, ENSP00000228307⁴	EBI-703044,EBI-702209 I2D: score=3 STRING: ENSP00000228307
YWHAZ	P63104²^,³, ENSP00000309503⁴	MINT-8008939 I2D: score=1 STRING: ENSP00000309503
TGFB1I1	O43294¹^,³, ENSP00000378332⁴	EBI-703044,EBI-1051449 I2D: score=2 STRING: ENSP00000378332
EED	O75530³, ENSP00000263360⁴	I2D: score=4 STRING: ENSP00000263360

About this table

Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001974	blood vessel remodeling	IEA	--
GO:0007155	cell adhesion	--	--
GO:0007157	heterophilic cell-cell adhesion	IEA	--
GO:0007159	leukocyte cell-cell adhesion	IDA	1715889
GO:0007229	integrin-mediated signaling pathway	IEA	--

ITGA4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGA4 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ITGA4 available from Tocris Bioscience About this table

Compound	Action	CAS #
LDV FITC	Fluorescent ligand for�alpha4beta1 (VLA-4)	[1207610-07-8]

2 DrugBank Compounds for ITGA4 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Natalizumab	Anti-alpha4 integrin (see all 2)	189261-10-7	target	antibody	16268663 11752352 17461891 16634035 9389694
Tinzaparin	--	9041-08-1	target	inhibitor	19888514

10/50 Novoseek chemical compound relationships for ITGA4 gene (see all 50) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
natalizumab	91.7	102	19188571 (4), 20453514 (4), 19283860 (3), 19278014 (3) (see all 60)
slex	69	21	9430509 (3), 8547121 (1), 12580864 (1), 16689823 (1) (see all 15)
slea	63	5	9430509 (3), 9733622 (1)
elan	54.3	3	15851719 (1), 16848686 (1), 14758775 (1)
alpha e	43	1	9683663 (1)
rantes	39.5	5	18700028 (2), 8855287 (1), 7542307 (1), 9155832 (1)
rgd peptide	37.5	1	8260708 (1)
grgdsp	37.3	2	1701798 (1)
fmlp	32	3	15242880 (1), 14525968 (1)
cytochalasin d	27.1	1	11274763 (1)

Search CenterWatch for drugs/clinical trials and news about ITGA4 / ITA4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGA4 gene:

NM_000885.4

Unigene Cluster for ITGA4:

Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Hs.440955 [show with all ESTs]

Unigene Representative Sequence: NM_000885

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000476089 ENST00000339307 ENST00000397033(uc002unu.3 uc002unv.3)

ENST00000465522(uc010zfl.1) ENST00000233573 ENST00000484404 ENST00000478440

ENST00000473002 ENST00000490435 ENST00000476824(uc010frj.1) ENST00000468948

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA4
		8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA4 (see all 35):
		hsa-miR-106a hsa-miR-301a hsa-miR-578 hsa-miR-30d hsa-miR-519a hsa-miR-30a hsa-miR-93 hsa-miR-526b*

		SwitchGear 3'UTR luciferase reporter plasmid: ITGA4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA4 (see all 7) OriGene shRNA RFP: ITGA4 OriGene siRNA: ITGA4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA4 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGA4 (NM_000885)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGA4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGA4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA4

Additional cDNA sequence:

AB208885.1 AJ504733.1 AJ508356.1 AJ510246.1 AJ510247.1 AJ510248.1 AJ510249.1 AK124630.1

AK303220.1 AK303478.1 AK310610.1 AK311738.1 BC016671.2 BC055419.1 BC080190.1 L12002.1

X16983.1

13 DOTS entries:

DT.97840348 DT.112809 DT.100757359 DT.100687935 DT.92423249 DT.203154 DT.75151267 DT.91996310

DT.99946353 DT.92423246 DT.92423248 DT.100650668 DT.120966512

24/142 AceView cDNA sequences (see all 142):

AW207267 CR618928 BU729877 AA490846 BC016671 AI363371 AI708160 AI393378

CR618530 AW770102 AA780167 CR608655 AJ713338 BX495101 CR608570 BG389093

BX492953 AL135563 AW499866 AW518281 CB528856 AJ510246 AA768667 AI611787

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA4 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^	16a	·	16b	^	17	^
SP1:													-						-				-												-												-
SP2:
SP3:													-
SP4:													-						-				-
SP5:

ExUns:	18	^	19	^	20a	·	20b	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29a	·	29b
SP1:					-
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ITGA4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGA4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTTAAAA

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ITGA4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Chorion

Chorion Bilayer

Chorionic Ectoderm Cells

Selective marker (cell-identifying gene)

Extraembryonic Tissues, Placenta

Heart

Epicardium

Epicardial Progenitors Cells

Epicardium

Kidney

Reproductive System

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

HNK1+p75+ cells (Derivation of neural...)

See ITGA4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGA4

SOURCE GeneReport for Unigene cluster: Hs.440955

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA4 (see all 6):

Extracellular Matrix & Adhesion Molecules in human mouse rat

Wound Healing in human mouse rat

Cell Junction PathwayFinder in human mouse rat

Focal Adhesions in human mouse rat

Cell Motility in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGA4 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITGA4¹	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of more	69.43(n) 62.07(a)		424121 XM_421974.3 XP_421974.3
lizard (Anolis carolinensis)	Reptilia	ITGA4⁶	--	62(a)	1 ↔ 1	GL343455.1(592477-641483)
African clawed frog (Xenopus laevis)	Amphibia	LOC397839²	integrin alpha 4	76.84(n)		U54497.1
zebrafish (Danio rerio)	Actinopterygii	LOC100331333¹	integrin alpha-4-like	60.14(n) 56.17(a)		100331333 XM_002663413.2 XP_002663459.2
fruit fly (Drosophila melanogaster)	Insecta	scb³	calcium-dependent cell-matrix adhesion cell adhesion more	27(a) (best of 3)		--

ENSEMBL Gene Tree for ITGA4 (if available)
TreeFam Gene Tree for ITGA4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGA4 gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA11² ITGA2²

ITGA5² ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGAL² ITGA9²

ITGA10²

9 SIMAP similar genes for ITGA4 using alignment to 6 protein entries: ITA4_HUMAN (see all proteins):

IA4 ITGA9 ITGA3 ITGA2B ITGA5 ITGAV

ITGA6 ITGA7 variant protein ITGA7

ITGA4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73026489^1,2	C,	--	174257886(+)	`ATCAAG/ACATAC`	7	--	int¹		2		WA	120
rs140533145^1,2	C,	--	174258095(+)	`TATTTC/TCTTGG`	7	--	int¹		0	--	--	--	--
rs59627849^1,2	C	--	174258153(+)	`GTGTTTACAAGTAT AAGTGTT/-ACCTT`	7	--	int¹		1		NA	2
rs2368213^1,2	C,F,	--	174258253(+)	`TGAGAC/TGACAG`	7	--	int¹ ese³		1		WA	118
rs183833132^1,2	C,	--	174258254(+)	`GAGACA/GACAGC`	7	--	int¹		0	--	--	--	--
rs11553355^1,2	C,	--	174258452(+)	`GTGGCC/TGAATT`	7	--	nc-transcript-variantut3¹		0	--	--	--	--
rs138526637^1,2	C,	--	174258564(+)	`CCTAAC/TTGATG`	7	--	nc-transcript-variantut3¹		0	--	--	--	--
rs189163426^1,2	C,	--	174258569(+)	`TTGATC/GAAAGT`	7	--	nc-transcript-variantut3¹		0	--	--	--	--
rs78381893^1,2	C,F,	--	174258731(+)	`TGTATC/TGTTAT`	7	--	nc-transcript-variantut3¹		1		WA	118
rs16867441^1,2	C,F,H,	--	174258732(+)	`GTATCG/ATTATA`	7	--	nc-transcript-variantut3¹		9		NA NS WA	1046

HapMap Linkage Disequilibrium report for ITGA4 (182321619 - 182402474 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ITGA4
8 Indels: 45910 41909 61866 58938 26503 98070 58939 40393
Human Gene Mutation Database (HGMD): ITGA4

SABiosciences Cancer Mutation PCR Assays

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DNA2.0 Custom Variant and Variant Library Synthesis for ITGA4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGA4 for disorders           About GeneDecksing

OMIM gene information: 192975    OMIM disorders: --

20/115 diseases for ITGA4 (see all 115):    About MalaCards

b-cell non-hodgkin lymphoma hypersensitivity reaction type ii disease progressive multifocal leukoencephalopathy non-hodgkin lymphoma

chronic venous leg ulcers severe combined immunodeficiency mycosis fungoides carpal tunnel syndrome

venous insufficiency blood clots waldenstrom macroglobulinemia malt lymphoma

combined immunodeficiency hemorrhagic fever arteriosclerosis obliterans inflammatory bowel disease

pediatric multiple sclerosis crescentic glomerulonephritis beta thalassemia primary biliary cirrhosis

3 diseases from the University of Copenhagen DISEASES database for ITGA4:

Progressive multifocal leukoencephalopathy Multiple sclerosis Inflammatory bowel disease

10/91 Novoseek disease relationships for ITGA4 gene (see all 91) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukoencephalopathy progressive multifocal	68.6	5	20442571 (1), 16827596 (1), 16932490 (1), 15947080 (1) (see all 5)
multiple sclerosis	64.4	35	17689671 (2), 11544011 (1), 16052610 (1), 18465535 (1) (see all 32)
inflammation	55.9	49	11857637 (3), 16918513 (3), 9399955 (2), 9516132 (2) (see all 37)
myeloma	50.9	49	14688392 (3), 11378537 (3), 8797890 (2), 7861616 (1) (see all 14)
multiple sclerosis relapsing-remitting	48.5	4	20442571 (1), 19064754 (1), 18673197 (1), 18836525 (1)
encephalomyelitis	46.6	7	9840619 (2), 7530745 (1), 8857744 (1), 10626664 (1) (see all 6)
necrosis	44	25	1709380 (1), 7488336 (1), 9058776 (1), 19309716 (1) (see all 21)
inflammatory bowel diseases	35.7	3	16856112 (1), 12943458 (1), 17253580 (1)
eosinophilia	32.1	8	11408770 (5), 9399955 (1), 8906116 (1)
demyelinating diseases	31.6	1	16268663 (1)

Genetic Association Database (GAD): ITGA4
Human Genome Epidemiology (HuGE) Navigator: ITGA4 (15 documents)

Export disorders for ITGA4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGA4 gene, integrated from 9 sources (see all 926):
(articles sorted by number of sources associating them with ITGA4)

Utopia: connect your pdf to the dynamic
world of online information

Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. (PubMed id 11533025)^{1, 2, 9} Han J....Ginsberg M.H. (2001)
A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. (PubMed id 9488735)^{1, 2, 9} Iida J.... McCarthy J.B. (1998)
Polymorphism of the alpha4-subunit of VLA-4 integrin and bone marrow transplantation. (PubMed id 15257952)^{1, 4} Heymann G.A....Salama A. (2004)
Frequencies of alpha4 A3061G variants and identification of three new variants of the human integrin alpha4-subunit. (PubMed id 12686501)^{1, 4} Heymann G.A.... Salama A. (2003)
Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. (PubMed id 10604475)^{1, 2} Liu S....Ginsberg M.H. (1999)
Identification of two variants of the human integrin alpha 4 subunit. (PubMed id 8643114)^{1, 2} Szabo M.C. and McIntyre B.W. (1995)
Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. (PubMed id 1730718)^{1, 2} Teixido J.... Hemler M.E. (1992)
Mapping of the human VLA-alpha 4 gene to chromosome 2q31-q32. (PubMed id 1537388)^{1, 3} Fernandez-Ruiz E....Sanchez-Madrid F. (1992)
A single mRNA encodes the alpha 150 and alpha 80/70 forms of the alpha subunit of VLA4. (PubMed id 1551405)^{1, 2} Rubio M.... Corbi-Lopez A.L. (1992)
Characterization of the alpha 4 integrin gene promoter. (PubMed id 2034655)^{1, 2} Rosen G.D.... Dean D.C. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3676	HGNC: 6140	AceView: ITGA4	Ensembl:ENSG00000115232	euGenes: HUgn3676
ECgene: ITGA4	Kegg: 3676	H-InvDB: ITGA4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGA4	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGA4	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGA4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGA4 gene:
Search GeneIP for patents involving ITGA4

Licensable Technologies for ITGA4 gene:

Weizmann Institute:

Enrichment of Repopulating Stem Cells For Clinical Protocols

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Leg Ulcer
Nephritis
Leukemia T-Cell
IMMUNE DISORDER
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AIDS
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ITGA4 Gene

integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4...

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