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Aliases for ITGA4 Gene

Aliases for ITGA4 Gene

  • Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor) 2 3
  • CD49D 3 4 6
  • CD49 Antigen-Like Family Member D 3 4
  • VLA-4 Subunit Alpha 3 4
  • Integrin Alpha-IV 3 4
  • Very Late Activation Protein 4 Receptor, Alpha 4 Subunit 3
  • Antigen CD49D, Alpha-4 Subunit Of VLA-4 Receptor 3
  • Integrin Alpha-4 Subunit 3
  • Integrin Alpha 4 3
  • Integrin Alpha-4 3
  • 269C Wild Type 3
  • CD49d Antigen 4
  • IA4 3

External Ids for ITGA4 Gene

Previous HGNC Symbols for ITGA4 Gene

  • CD49D

Previous GeneCards Identifiers for ITGA4 Gene

  • GC02P180528
  • GC02P181004
  • GC02P182285
  • GC02P182524
  • GC02P182525
  • GC02P182146
  • GC02P182029
  • GC02P174178

Summaries for ITGA4 Gene

Entrez Gene Summary for ITGA4 Gene

  • The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA4 Gene

ITGA4 (Integrin, Alpha 4 (Antigen CD49D, Alpha 4 Subunit Of VLA-4 Receptor)) is a Protein Coding gene. Diseases associated with ITGA4 include chronic venous insufficiency and breast sarcoma. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include fibronectin binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA4 Gene

  • Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Tocris Summary for ITGA4 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA4 Gene

Genomics for ITGA4 Gene

Regulatory Elements for ITGA4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGA4 Gene

Start:
181,456,892 bp from pter
End:
181,537,747 bp from pter
Size:
80,856 bases
Orientation:
Plus strand

Genomic View for ITGA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA4 Gene

Proteins for ITGA4 Gene

  • Protein details for ITGA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13612-ITA4_HUMAN
    Recommended name:
    Integrin alpha-4
    Protein Accession:
    P13612
    Secondary Accessions:
    • D3DPG4
    • Q7Z4L6

    Protein attributes for ITGA4 Gene

    Size:
    1032 amino acids
    Molecular mass:
    114900 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Interacts with AMICA1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling AMICA1 homodimerization.
    SequenceCaution:
    • Sequence=AAB59613.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305}; Sequence=CAA34852.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ITGA4 Gene

    Alternative splice isoforms for ITGA4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA4 Gene

Proteomics data for ITGA4 Gene at MOPED

Post-translational modifications for ITGA4 Gene

  • Phosphorylation on Ser-1027 inhibits PXN binding.
  • Ubiquitination at Lys95, Lys116, Lys149, Lys190, Lys241, Lys280, Lys289, Lys363, Lys590, Lys614, Lys760, Lys771, Lys867, Lys892, and Lys1028
  • Glycosylation at Asn79, Asn138, Asn229, Asn480, Asn518, Asn538, Asn626, Asn645, Asn660, Asn806, and Asn821
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGA4 (Integrin alpha 4/CD49d)
  • Cell Signaling Technology (CST) Antibodies for ITGA4 (ITGA4)

No data available for DME Specific Peptides for ITGA4 Gene

Domains for ITGA4 Gene

Gene Families for ITGA4 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGA4 Gene

Graphical View of Domain Structure for InterPro Entry

P13612

UniProtKB/Swiss-Prot:

ITA4_HUMAN :
  • P13612
Domain:
  • The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA4: view

Function for ITGA4 Gene

Molecular function for ITGA4 Gene

GENATLAS Biochemistry: integrin,alpha 4,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,component of VLA-4 receptor,dimerizing with ITGB1 or ITGB7 in fibronectin,VCAM1 receptors
UniProtKB/Swiss-Prot Function: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.

Gene Ontology (GO) - Molecular Function for ITGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IEA --
GO:0005515 protein binding IPI 10604475
GO:0046872 metal ion binding IEA --
GO:0050839 cell adhesion molecule binding IPI 12869515
genes like me logo Genes that share ontologies with ITGA4: view
genes like me logo Genes that share phenotypes with ITGA4: view

Animal Models for ITGA4 Gene

MGI Knock Outs for ITGA4:

Animal Model Products

miRNA for ITGA4 Gene

miRTarBase miRNAs that target ITGA4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA4 Gene

Localization for ITGA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA4 Gene COMPARTMENTS Subcellular localization image for ITGA4 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 2
extracellular 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ITGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ITGA4: view

Pathways for ITGA4 Gene

genes like me logo Genes that share pathways with ITGA4: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ITGA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0003366 cell-matrix adhesion involved in ameboidal cell migration IMP 23986478
GO:0007155 cell adhesion --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA --
GO:0007159 leukocyte cell-cell adhesion IDA 1715889
genes like me logo Genes that share ontologies with ITGA4: view

Compounds for ITGA4 Gene

(5) Tocris Compounds for ITGA4 Gene

Compound Action Cas Number
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0]
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 [327613-57-0]
Eptifibatide Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation [188627-80-7]
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5]

(2) Drugbank Compounds for ITGA4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Natalizumab
  • Anti-alpha4 integrin
189261-10-7 target antibody
Tinzaparin
9041-08-1 target inhibitor

(50) Novoseek inferred chemical compound relationships for ITGA4 Gene

Compound -log(P) Hits PubMed IDs
natalizumab 91.7 83
slex 69 17
slea 63 4
elan 54.3 3
alpha e 43 1
genes like me logo Genes that share compounds with ITGA4: view

Transcripts for ITGA4 Gene

Unigene Clusters for ITGA4 Gene

Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITGA4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA4 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^
SP1: - - - - -
SP2:
SP3: -
SP4: - - -
SP5:
SP6: - - -
SP7:
SP8:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ITGA4 Gene

GeneLoc Exon Structure for
ITGA4
ECgene alternative splicing isoforms for
ITGA4

Expression for ITGA4 Gene

mRNA expression in normal human tissues for ITGA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA4 Gene

This gene is overexpressed in Whole Blood (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA4 Gene

SOURCE GeneReport for Unigene cluster for ITGA4 Gene Hs.440955

genes like me logo Genes that share expressions with ITGA4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ITGA4 Gene

Orthologs for ITGA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA4 35
  • 99.35 (n)
  • 99.42 (a)
ITGA4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA4 35
  • 87.47 (n)
  • 85.76 (a)
ITGA4 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA4 35
  • 87.99 (n)
  • 87.89 (a)
ITGA4 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga4 35
  • 84.21 (n)
  • 84.88 (a)
Itga4 16
Itga4 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA4 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA4 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga4 35
  • 84.5 (n)
  • 84.5 (a)
chicken
(Gallus gallus)
Aves ITGA4 35
  • 69.57 (n)
  • 62.35 (a)
ITGA4 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA4 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397839 35
tropical clawed frog
(Silurana tropicalis)
Amphibia itga4 35
  • 63.04 (n)
  • 55.73 (a)
zebrafish
(Danio rerio)
Actinopterygii itga4 35
  • 60.02 (n)
  • 56.04 (a)
itga4 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alphaPS4 36
  • 21 (a)
ManyToMany
alphaPS5 36
  • 23 (a)
ManyToMany
scb 36
  • 22 (a)
ManyToMany
scb 37
  • 27 (a)
alphaPS5 37
  • 26 (a)
alphaPS4 37
  • 24 (a)
Species with no ortholog for ITGA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA4 Gene

ENSEMBL:
Gene Tree for ITGA4 (if available)
TreeFam:
Gene Tree for ITGA4 (if available)

Paralogs for ITGA4 Gene

Selected SIMAP similar genes for ITGA4 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ITGA4: view

Variants for ITGA4 Gene

Sequence variations from dbSNP and Humsavar for ITGA4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs149724 -- 181,494,438(+) CCCCA(C/T)CTCTA intron-variant
rs149725 -- 181,460,749(+) TCTGT(A/G)TGTTA intron-variant
rs155085 -- 181,498,313(+) AAGAC(A/T)TTTAT intron-variant
rs155086 -- 181,475,500(-) GTTAT(C/T)CAAAT intron-variant
rs155087 -- 181,476,947(-) tgcct(A/G)ctttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA4 Gene

Variant ID Type Subtype PubMed ID
nsv834476 CNV Gain 17160897
nsv3063 CNV Insertion 18451855
nsv819894 CNV Loss 19587683
esv2620400 CNV Deletion 19546169
esv1979132 CNV Deletion 18987734
esv3344 CNV Deletion 18987735
esv2721204 CNV Deletion 23290073
esv2517753 CNV Deletion 19546169
esv6797 CNV Loss 19470904
esv1005604 CNV Deletion 20482838
esv1571329 CNV Deletion 17803354
nsv819063 CNV Loss 19587683

Relevant External Links for ITGA4 Gene

HapMap Linkage Disequilibrium report
ITGA4
Human Gene Mutation Database (HGMD)
ITGA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA4 Gene

Disorders for ITGA4 Gene

(91) Novoseek inferred disease relationships for ITGA4 Gene

Disease -log(P) Hits PubMed IDs
leukoencephalopathy progressive multifocal 68.6 5
multiple sclerosis 64.4 33
inflammation 55.9 43
myeloma 50.9 19
multiple sclerosis relapsing-remitting 48.5 4

Relevant External Links for ITGA4

Genetic Association Database (GAD)
ITGA4
Human Genome Epidemiology (HuGE) Navigator
ITGA4
genes like me logo Genes that share disorders with ITGA4: view

No data available for UniProtKB/Swiss-Prot for ITGA4 Gene

Publications for ITGA4 Gene

  1. Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. (PMID: 11533025) Han J. … Ginsberg M.H. (J. Biol. Chem. 2001) 3 4 23
  2. A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion. (PMID: 9488735) Iida J. … McCarthy J.B. (J. Biol. Chem. 1998) 3 4 23
  3. ITGA4 polymorphisms and susceptibility to multiple sclerosis. (PMID: 17689671) O'Doherty C. … Vandenbroeck K. (J. Neuroimmunol. 2007) 3 23 48
  4. Association of the alpha4 integrin subunit gene (ITGA4) with autism. (PMID: 19259978) Correia C. … Vicente A.M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23 48
  5. CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma. (PMID: 18697202) Lee E.J. … Kim D.H. (Int. J. Cancer 2008) 3 23

Products for ITGA4 Gene

Sources for ITGA4 Gene

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