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Aliases for ITGA3 Gene

Aliases for ITGA3 Gene

  • Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor) 2 3
  • GAPB3 3 4 6
  • Antigen Identified By Monoclonal Antibody J143 2 3
  • CD49 Antigen-Like Family Member C 3 4
  • VLA-3 Subunit Alpha 3 4
  • Galactoprotein B3 3 4
  • MSK18 3 4
  • CD49C 3 6
  • ILNEB 3 6
  • FRP-2 3 4
  • Very Late Activation Protein 3 Receptor, Alpha-3 Subunit 3
  • Integrin Alpha-3 3
  • CD49c Antigen 4
  • GAP-B3 3
  • VCA-2 3
  • VLA3a 3
  • VL3A 3

External Ids for ITGA3 Gene

Previous HGNC Symbols for ITGA3 Gene

  • MSK18

Previous GeneCards Identifiers for ITGA3 Gene

  • GC17P047940
  • GC17P050613
  • GC17P048475
  • GC17P048608
  • GC17P045488
  • GC17P048133
  • GC17P043500

Summaries for ITGA3 Gene

Entrez Gene Summary for ITGA3 Gene

  • The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for ITGA3 Gene

ITGA3 (Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor)) is a Protein Coding gene. Diseases associated with ITGA3 include interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital and interstitial lung disease. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA3 Gene

  • Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Gene Wiki entry for ITGA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA3 Gene

Genomics for ITGA3 Gene

Regulatory Elements for ITGA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGA3 Gene

Start:
50,055,968 bp from pter
End:
50,090,485 bp from pter
Size:
34,518 bases
Orientation:
Plus strand

Genomic View for ITGA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA3 Gene

Proteins for ITGA3 Gene

  • Protein details for ITGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26006-ITA3_HUMAN
    Recommended name:
    Integrin alpha-3
    Protein Accession:
    P26006
    Secondary Accessions:
    • A7E246
    • B7ZM80
    • B9EGQ1
    • D3DTX4
    • D3DTX5

    Protein attributes for ITGA3 Gene

    Size:
    1051 amino acids
    Molecular mass:
    116612 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner.

    Alternative splice isoforms for ITGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA3 Gene

Proteomics data for ITGA3 Gene at MOPED

Post-translational modifications for ITGA3 Gene

  • Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
  • Glycosylation at Asn86, Asn107, Asn265, Asn500, Asn511, Asn573, Asn605, Asn656, Asn697, Asn841, Asn857, Asn926, Asn935, and Asn969
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA3 Gene

Antibody Products

  • R&D Systems Antibodies for ITGA3 (Integrin alpha 3/CD49c)

No data available for DME Specific Peptides for ITGA3 Gene

Domains for ITGA3 Gene

Gene Families for ITGA3 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Graphical View of Domain Structure for InterPro Entry

P26006

UniProtKB/Swiss-Prot:

ITA3_HUMAN :
  • P26006
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA3: view

Function for ITGA3 Gene

Molecular function for ITGA3 Gene

GENATLAS Biochemistry:
integrin,alpha 3,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB1 in fibronectin,laminin,collagen receptors
UniProtKB/Swiss-Prot Function:
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Gene Ontology (GO) - Molecular Function for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 24220332
GO:0001968 fibronectin binding IEA --
GO:0002020 protease binding IPI 10455171
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 14676841
genes like me logo Genes that share ontologies with ITGA3: view
genes like me logo Genes that share phenotypes with ITGA3: view

Animal Models for ITGA3 Gene

MGI Knock Outs for ITGA3:

miRNA for ITGA3 Gene

miRTarBase miRNAs that target ITGA3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA3 Gene

Localization for ITGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA3 Gene

Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269 PubMed:10455171}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA3 Gene COMPARTMENTS Subcellular localization image for ITGA3 gene
Compartment Confidence
plasma membrane 4
golgi apparatus 3
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex TAS 1655803
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 19581412
genes like me logo Genes that share ontologies with ITGA3: view

Pathways for ITGA3 Gene

genes like me logo Genes that share pathways with ITGA3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007155 cell adhesion --
GO:0007160 cell-matrix adhesion TAS 1655803
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with ITGA3: view

Compounds for ITGA3 Gene

(4) Novoseek inferred chemical compound relationships for ITGA3 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 16.6 1
retinoid 15.6 1
tyrosine 0 1
serine 0 1
genes like me logo Genes that share compounds with ITGA3: view

Transcripts for ITGA3 Gene

Unigene Clusters for ITGA3 Gene

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: - -
SP3: - - - - - - - - -
SP4:
SP5: -
SP6: -
SP7: - - - - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for ITGA3 Gene

GeneLoc Exon Structure for
ITGA3
ECgene alternative splicing isoforms for
ITGA3

Expression for ITGA3 Gene

mRNA expression in normal human tissues for ITGA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ITGA3 Gene

This gene is overexpressed in Liver (26.7), Bone (12.0), and Amniocyte (10.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA3 Gene

SOURCE GeneReport for Unigene cluster for ITGA3 Gene Hs.265829

mRNA Expression by UniProt/SwissProt for ITGA3 Gene

P26006-ITA3_HUMAN
Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
genes like me logo Genes that share expressions with ITGA3: view

Expression partners for ITGA3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ITGA3 Gene

Orthologs for ITGA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGA3 35
  • 89.55 (n)
  • 90.05 (a)
ITGA3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA3 35
  • 89.52 (n)
  • 89.96 (a)
ITGA3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga3 35
  • 85.14 (n)
  • 86.26 (a)
Itga3 16
Itga3 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGA3 35
  • 99.16 (n)
  • 99.2 (a)
ITGA3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga3 35
  • 84.82 (n)
  • 85.98 (a)
oppossum
(Monodelphis domestica)
Mammalia ITGA3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA3 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA3 35
  • 67.85 (n)
  • 63.93 (a)
lizard
(Anolis carolinensis)
Reptilia ITGA3 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494331 35
  • 58.37 (n)
  • 55.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia itga3-A 35
zebrafish
(Danio rerio)
Actinopterygii itga3a 36
  • 40 (a)
OneToMany
itga3b 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta alphaPS5 37
  • 25 (a)
mew 37
  • 29 (a)
mew 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ina-1 37
  • 27 (a)
ina-1 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
ManyToMany
CSA.6547 36
  • 29 (a)
ManyToMany
Species with no ortholog for ITGA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA3 Gene

ENSEMBL:
Gene Tree for ITGA3 (if available)
TreeFam:
Gene Tree for ITGA3 (if available)

Paralogs for ITGA3 Gene

Selected SIMAP similar genes for ITGA3 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ITGA3 Gene

genes like me logo Genes that share paralogs with ITGA3: view

Variants for ITGA3 Gene

Sequence variations from dbSNP and Humsavar for ITGA3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs199147 -- 50,058,203(-) AACCC(C/G)TTTTG intron-variant
rs756847 -- 50,080,685(-) AAAAC(A/G)AAATA intron-variant
rs756848 -- 50,080,557(-) AAAGG(C/T)CATTT intron-variant
rs875511 -- 50,081,837(-) GTGGA(C/T)GTGAC intron-variant
rs878070 -- 50,065,611(-) CCACC(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA3 Gene

Variant ID Type Subtype PubMed ID
nsv833474 CNV Loss 17160897
nsv908588 CNV Loss 21882294
nsv509660 CNV Insertion 20534489
nsv908590 CNV Loss 21882294
dgv3225n71 CNV Loss 21882294
esv993321 CNV Insertion 20482838
esv1740779 CNV Insertion 17803354
dgv3226n71 CNV Loss 21882294

Relevant External Links for ITGA3 Gene

HapMap Linkage Disequilibrium report
ITGA3
Human Gene Mutation Database (HGMD)
ITGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA3 Gene

Disorders for ITGA3 Gene

(1) OMIM Diseases for ITGA3 Gene (605025)

UniProtKB/Swiss-Prot

ITA3_HUMAN
  • Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB) [MIM:614748]: A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. {ECO:0000269 PubMed:22512483}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(14) Novoseek inferred disease relationships for ITGA3 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 25.8 1
tumors 21.7 7
metastasis 21.2 1
melanoma 20.9 2
carcinoma 19.6 1

Relevant External Links for ITGA3

Genetic Association Database (GAD)
ITGA3
Human Genome Epidemiology (HuGE) Navigator
ITGA3
genes like me logo Genes that share disorders with ITGA3: view

No data available for University of Copenhagen DISEASES and Genatlas for ITGA3 Gene

Publications for ITGA3 Gene

  1. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. (PMID: 1655803) Takada Y. … Hemler M.E. (J. Cell Biol. 1991) 2 3 4 23
  2. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. (PMID: 1714443) Tsuji T. … Osawa T. (J. Biochem. 1991) 3 4 23
  3. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. (PMID: 9111516) de Melker A.A. … Sonnenberg A. (Lab. Invest. 1997) 3 4 23
  4. Enhancement of metastatic activity of colon cancer as influenced by expression of cell surface antigens. (PMID: 9733622) Okazaki K. … Itoh H. (J. Surg. Res. 1998) 3 23
  5. Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. (PMID: 10929059) Ammon C. … Kreutz M. (Immunology 2000) 3 23

Products for ITGA3 Gene

Sources for ITGA3 Gene

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