Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ITGA3 Gene

Aliases for ITGA3 Gene

  • Integrin Subunit Alpha 3 2 3 5
  • Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor) 2 3
  • Antigen Identified By Monoclonal Antibody J143 2 3
  • Alpha 3 Subunit Of VLA-3 Receptor 2 3
  • CD49 Antigen-Like Family Member C 3 4
  • Galactoprotein B3 3 4
  • Antigen CD49C 2 3
  • MSK18 3 4
  • FRP-2 3 4
  • GAPB3 3 4
  • Very Late Activation Protein 3 Receptor, Alpha-3 Subunit 3
  • Testicular Tissue Protein Li 96 3
  • Testicular Tissue Protein Li 98 3
  • VLA-3 Subunit Alpha 4
  • Integrin Alpha 3 3
  • Integrin Alpha-3 3
  • CD49c Antigen 4
  • GAP-B3 3
  • CD49C 3
  • ILNEB 3
  • VCA-2 3
  • VLA3a 3
  • VL3A 3

External Ids for ITGA3 Gene

Previous HGNC Symbols for ITGA3 Gene

  • MSK18

Previous GeneCards Identifiers for ITGA3 Gene

  • GC17P047940
  • GC17P050613
  • GC17P048475
  • GC17P048608
  • GC17P045488
  • GC17P048133
  • GC17P043500

Summaries for ITGA3 Gene

Entrez Gene Summary for ITGA3 Gene

  • The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

GeneCards Summary for ITGA3 Gene

ITGA3 (Integrin Subunit Alpha 3) is a Protein Coding gene. Diseases associated with ITGA3 include Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital and Lrba-Related Common Variable Immune Deficiency. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and CXCR4-mediated signaling events. GO annotations related to this gene include protein heterodimerization activity and integrin binding. An important paralog of this gene is ITGA7.

UniProtKB/Swiss-Prot for ITGA3 Gene

  • Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Gene Wiki entry for ITGA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA3 Gene

Genomics for ITGA3 Gene

Regulatory Elements for ITGA3 Gene

Enhancers for ITGA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F050046 1.5 FANTOM5 ENCODE 11.4 +0.9 947 21.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF143 FOS DEK ZNF263 SP3 PDK2 LOC105371824 ENSG00000250282 ITGA3 COL1A1 ENSG00000262837 DLX3 ENSG00000248172 SAMD14 LOC284080
GH17F050026 1.5 FANTOM5 Ensembl ENCODE 5.2 -28.1 -28068 3.4 TBP SIN3A RAD21 RFX5 ELK1 ZNF366 ZNF143 RCOR1 FOS ZNF391 ITGA3 LRRC59 XYLT2 LOC284080 ENSG00000248172
GH17F050079 0.9 ENCODE 7 +24.7 24652 2.4 CBX3 ARID4B SIN3A ZNF48 RAD21 ZNF121 ZNF143 CREM EGR2 ZNF202 ENSG00000262837 ENSG00000250282 ENSG00000253730 SGCA HILS1 ENSG00000248172 DLX3 ITGA3 LOC284080 ENSG00000276851
GH17F050107 1.2 Ensembl ENCODE 4.7 +54.8 54753 6.4 ZFP64 ARID4B ZNF48 ZNF121 ELK1 FOS ZNF263 REST ZNF623 ZNF518A PDK2 ENSG00000262837 COL1A1 ENSG00000253730 SGCA HILS1 ENSG00000248172 DLX3 CACNA1G-AS1 SAMD14
GH17F050095 1.1 ENCODE 4.7 +39.6 39592 3.4 HDGF MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PDK2 NXPH3 ITGA3 ENSG00000275025
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITGA3 on UCSC Golden Path with GeneCards custom track

Promoters for ITGA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001348628 532 3001 PKNOX1 SIN3A FEZF1 ZNF121 GLIS2 KLF7 DEK SP3 ZHX2 REST

Genomic Location for ITGA3 Gene

Chromosome:
17
Start:
50,055,968 bp from pter
End:
50,090,485 bp from pter
Size:
34,518 bases
Orientation:
Plus strand

Genomic View for ITGA3 Gene

Genes around ITGA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA3 Gene

Proteins for ITGA3 Gene

  • Protein details for ITGA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26006-ITA3_HUMAN
    Recommended name:
    Integrin alpha-3
    Protein Accession:
    P26006
    Secondary Accessions:
    • A7E246
    • B7ZM80
    • B9EGQ1
    • D3DTX4
    • D3DTX5

    Protein attributes for ITGA3 Gene

    Size:
    1051 amino acids
    Molecular mass:
    116612 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner.

    Alternative splice isoforms for ITGA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA3 Gene

Post-translational modifications for ITGA3 Gene

  • Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation.
  • Glycosylation at Asn 86, Asn 107, Asn 265, Asn 500, Asn 511, Asn 573, Asn 605, Asn 656, Asn 697, Asn 841, Asn 857, Asn 926, Asn 935, and Asn 969
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ITGA3 Gene

Domains & Families for ITGA3 Gene

Gene Families for ITGA3 Gene

Graphical View of Domain Structure for InterPro Entry

P26006

UniProtKB/Swiss-Prot:

ITA3_HUMAN :
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA3: view

Function for ITGA3 Gene

Molecular function for ITGA3 Gene

GENATLAS Biochemistry:
integrin,alpha 3,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB1 in fibronectin,laminin,collagen receptors
UniProtKB/Swiss-Prot Function:
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.

Gene Ontology (GO) - Molecular Function for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI 24220332
GO:0001968 fibronectin binding IEA --
GO:0002020 protease binding IPI 10455171
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 1911778
genes like me logo Genes that share ontologies with ITGA3: view
genes like me logo Genes that share phenotypes with ITGA3: view

Human Phenotype Ontology for ITGA3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITGA3 Gene

MGI Knock Outs for ITGA3:

Animal Model Products

miRNA for ITGA3 Gene

miRTarBase miRNAs that target ITGA3

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ITGA3 (Integrin alpha 3/CD49c)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGA3 Gene

Localization for ITGA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA3 Gene

Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Note=Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. {ECO:0000269 PubMed:10455171}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITGA3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0008305 integrin complex IEA,TAS 1655803
GO:0009897 external side of plasma membrane IEA --
GO:0009986 cell surface IDA 19581412
genes like me logo Genes that share ontologies with ITGA3: view

Pathways & Interactions for ITGA3 Gene

genes like me logo Genes that share pathways with ITGA3: view

Gene Ontology (GO) - Biological Process for ITGA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0007155 cell adhesion IEA --
GO:0007160 cell-matrix adhesion TAS 1655803
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with ITGA3: view

No data available for SIGNOR curated interactions for ITGA3 Gene

Drugs & Compounds for ITGA3 Gene

(2) Drugs for ITGA3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ITGA3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGA3: view

Transcripts for ITGA3 Gene

Unigene Clusters for ITGA3 Gene

Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for ITGA3 (Integrin alpha 3/CD49c)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a ·
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5:
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - -
SP8:
SP9:
SP10:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
SP1: - -
SP2: - -
SP3: - - - - - - - - -
SP4:
SP5: -
SP6: -
SP7: - - - - - - - - - - -
SP8:
SP9:
SP10:

Relevant External Links for ITGA3 Gene

GeneLoc Exon Structure for
ITGA3
ECgene alternative splicing isoforms for
ITGA3

Expression for ITGA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ITGA3 Gene

Protein differential expression in normal tissues from HIPED for ITGA3 Gene

This gene is overexpressed in Liver (26.7), Bone (12.0), and Amniocyte (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGA3 Gene



Protein tissue co-expression partners for ITGA3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ITGA3 Gene:

ITGA3

SOURCE GeneReport for Unigene cluster for ITGA3 Gene:

Hs.265829

mRNA Expression by UniProt/SwissProt for ITGA3 Gene:

P26006-ITA3_HUMAN
Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
genes like me logo Genes that share expression patterns with ITGA3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ITGA3 Gene

Orthologs for ITGA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA3 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia ITGA3 34 35
  • 89.55 (n)
dog
(Canis familiaris)
Mammalia ITGA3 34 35
  • 89.52 (n)
mouse
(Mus musculus)
Mammalia Itga3 34 16 35
  • 85.14 (n)
rat
(Rattus norvegicus)
Mammalia Itga3 34
  • 84.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA3 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA3 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA3 34
  • 67.85 (n)
lizard
(Anolis carolinensis)
Reptilia ITGA3 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494331 34
  • 58.37 (n)
African clawed frog
(Xenopus laevis)
Amphibia itga3-A 34
zebrafish
(Danio rerio)
Actinopterygii itga3b 35
  • 46 (a)
OneToMany
itga3a 35
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mew 36 35
  • 29 (a)
alphaPS5 36
  • 25 (a)
worm
(Caenorhabditis elegans)
Secernentea ina-1 36 35
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6547 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
Species where no ortholog for ITGA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA3 Gene

ENSEMBL:
Gene Tree for ITGA3 (if available)
TreeFam:
Gene Tree for ITGA3 (if available)

Paralogs for ITGA3 Gene

Pseudogenes.org Pseudogenes for ITGA3 Gene

genes like me logo Genes that share paralogs with ITGA3: view

Variants for ITGA3 Gene

Sequence variations from dbSNP and Humsavar for ITGA3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs140781106 Pathogenic, Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB) [MIM:614748] 50,076,642(+) GATGC(A/C/G)GGCAG nc-transcript-variant, reference, missense
rs797044989 Pathogenic 50,074,452(+) GGGCC(C/T)GGCCC nc-transcript-variant, reference, missense
rs797045048 Pathogenic 50,077,122(+) GCCCC(A/G)TGAGT splice-donor-variant
rs540704248 Likely pathogenic 50,077,024(+) CGTGA(C/G/T)GAACA nc-transcript-variant, reference, missense
rs1042182 -- 50,079,473(+) AGGCG(C/G)CGACA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ITGA3 Gene

Variant ID Type Subtype PubMed ID
nsv954572 CNV deletion 24416366
nsv833474 CNV loss 17160897
nsv509660 CNV insertion 20534489
nsv1142222 CNV tandem duplication 24896259
esv993321 CNV insertion 20482838
esv3418171 CNV duplication 20981092
esv1740779 CNV insertion 17803354

Variation tolerance for ITGA3 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA3 Gene

Human Gene Mutation Database (HGMD)
ITGA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA3 Gene

Disorders for ITGA3 Gene

MalaCards: The human disease database

(11) MalaCards diseases for ITGA3 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital
  • interstitial lung disease, nephrotic syndrome and epidermolysis bullosa, congenital
lrba-related common variable immune deficiency
  • immunodeficiency, common variable, 8, with autoimmunity
hydrocele
  • testicular hydrocele
interstitial lung disease
  • ild
villous adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards
Search ITGA3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ITA3_HUMAN
  • Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB) [MIM:614748]: A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the lethal course of the disease. {ECO:0000269 PubMed:22512483}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ITGA3

Genetic Association Database (GAD)
ITGA3
Human Genome Epidemiology (HuGE) Navigator
ITGA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGA3
genes like me logo Genes that share disorders with ITGA3: view

No data available for Genatlas for ITGA3 Gene

Publications for ITGA3 Gene

  1. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. (PMID: 1655803) Takada Y. … Hemler M.E. (J. Cell Biol. 1991) 2 3 4 22 64
  2. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. (PMID: 9111516) de Melker A.A. … Sonnenberg A. (Lab. Invest. 1997) 3 4 22 64
  3. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. (PMID: 1714443) Tsuji T. … Osawa T. (J. Biochem. 1991) 3 4 22 64
  4. Integrin alpha3 mutations with kidney, lung, and skin disease. (PMID: 22512483) Has C. … Laube G.F. (N. Engl. J. Med. 2012) 3 4 64
  5. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PMID: 19339270) Canova C. … Brennan P. (Cancer Res. 2009) 3 46 64

Products for ITGA3 Gene

Sources for ITGA3 Gene

Content
Loading form....