Aliases for ITGA3 Gene
External Ids for ITGA3 Gene
Previous HGNC Symbols for ITGA3 Gene
Previous GeneCards Identifiers for ITGA3 Gene
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]
GeneCards Summary for ITGA3 Gene
ITGA3 (Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor)) is a Protein Coding gene. Diseases associated with ITGA3 include lrba-related common variable immune deficiency and interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include protein heterodimerization activity and integrin binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA3 Gene
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.