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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA3 Gene

protein-coding   GIFtS: 65
GCID: GC17P048133

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3...

(Previous name: antigen identified by monoclonal antibody J143 )
(Previous symbol: MSK18)
 Explore 65 diseases affiliated with
ITGA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITGA3    

Aliases
for ITGA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3 Receptor)1 2     CD49 Antigen-Like Family Member C2 3
MSK181 2 3     VLA-3 Subunit Alpha2 3
GAPB32 3 5     CD49C2 5
GAP-B31 2     CD49c1
VCA-21 2     ILNEB2
VLA3a1 2     VL3A2
Antigen Identified By Monoclonal Antibody J1431 2     Integrin Alpha-32
Galactoprotein B32 3     Very Late Activation Protein 3 Receptor, Alpha-3 Subunit2
FRP-22 3     CD49c Antigen3

External Ids:    HGNC: 61391   Entrez Gene: 36752   Ensembl: ENSG000000058847   OMIM: 6050255   UniProtKB: P260063   

Export aliases for ITGA3 gene to outside databases

Previous GC identifers: GC17P047940 GC17P050613 GC17P048475 GC17P048608 GC17P045488 GC17P043500


Summaries
for ITGA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ITGA3:
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane
proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene
encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield
disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many
extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been
identified for this gene. (provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
Function: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and
CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration

Gene Wiki entry for ITGA3 (CD49c)


Genomic Views
for ITGA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA3 gene promoter:
         GR   STAT5B   Sp1   GR-beta   STAT1beta   AP-4   Nkx2-5   HEN1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

ITGA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048133:  view genomic region     (about GC identifiers)

Start:
 48,133,332 bp from pter      End:
 48,167,849 bp from pter
Size:
 34,518 bases      Orientation:
 plus strand

Proteins
for ITGA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006 (See protein sequence)
Recommended Name: Integrin alpha-3 precursor  
Size: 1051 amino acids; 116612 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked
by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A7E246 B7ZM80 B9EGQ1 D3DTX4 D3DTX5
Alternative splicing: 2 isoforms:  P26006-2   P26006-1   

Explore the universe of human proteins at neXtProt for ITGA3: NX_P26006

Post-translational modifications:

  • Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol
    • 12-myristate 13-acetate stimulation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26006

    • ITGA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_002195.1  NP_005492.1  

    ENSEMBL proteins: 
     ENSP00000422826   ENSP00000315190   ENSP00000007722   ENSP00000466652   ENSP00000425980  
     ENSP00000426142   ENSP00000467851   ENSP00000446133  
    Reactome Protein details: P26006
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant ITGA3 Protein
    R&D Systems Recombinant & Natural Proteins for ITGA3 (Integrin alpha 3 beta 1/VLA-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 2): ITGA3
    OriGene Custom Protein Services for ITGA3 
    GenScript Custom Purified and Recombinant Proteins Services for ITGA3
    Novus Biologicals ITGA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009986cell surface IDA--
    GO:0016323basolateral plasma membrane IEA--
    GO:0019717synaptosome ----


    ITGA3 for ontologies           About GeneDecksing



    ITGA3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA3
    R&D Systems Antibodies for ITGA3 (Integrin alpha 3/CD49c)
    Browse OriGene Antibodies
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    Novus Biologicals ITGA3 Antibodies
    Search for Antibodies for ITGA3 at Abcam  
    Browse Antibodies at Uscn
    ThermoFisher Antibodies for ITGA3

    Assay Products for ITGA3: 
    EMD Millipore Kits and Assays for the Analysis of ITGA3
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems Multiplex/Array Assay Kits & Reagents for ITGA3 (Integrin alpha 3/CD49c)
    GenScript Custom Assay Services for ITGA3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ITGA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITGA3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000413 Integrin_alpha
     IPR013519 Int_alpha_beta-p
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2

    Graphical View of Domain Structure for InterPro Entry P26006

    ProtoNet protein and cluster: P26006

    3 Blocks protein families:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    Function
    for ITGA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
    Function: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and
    CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration

         Genatlas biochemistry entry for ITGA3:
    integrin,alpha 3,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB1 in fibronectin,laminin,collagen receptors

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): ITGA3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA3
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA3 (see all 43):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-223 hsa-miR-124 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: ITGA3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA3 (see all 7)
    OriGene shRNA RFP: ITGA3
    OriGene siRNA: ITGA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ITGA3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGA3 (NM_005501)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA3 

    Cell Line
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    Search LifeMap BioReagents cell lines for ITGA3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI1911778
    GO:0046872metal ion binding IEA--


    ITGA3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ITGA3:
     Decreased TP53 protein express  Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Itga3tm1Jak for ITGA3
         15 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Itga3):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  renal/urinary system  respiratory system  vision/eye 

    ITGA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ITGA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/32 super-pathways (see all 32) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cytoskeleton remodeling Integrin outside-in signaling0.37
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cell adhesion_Endothelial cell contacts by non-junctional mechanisms0.21
    		Cytoskeleton remodeling_Integrin outside-in signaling0.37
    		Cell adhesion Endothelial cell contacts by non-junctional mechanisms0.21
    2Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    3Apoptotic Pathways in Synovial Fibroblasts
    		PPAR Pathway0.66
    		Actin-Based Motility by Rho Family GTPases0.52
    		Rac1 Pathway0.58
    		Rap1 Pathway0.42
    		Glioma Invasiveness0.54
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		RhoA Pathway0.35
    		Actin Nucleation and Branching0.66
    		CDC42 Pathway0.34
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    		MAPK Signaling0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for ITGA3
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA3 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for ITGA3
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration

    5/7 BioSystems Pathways for ITGA3 (see all 7) 
        Integrin-mediated cell adhesion
    Focal Adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Arf6 trafficking events
    CXCR4-mediated signaling events

    5        Reactome Pathways for ITGA3
        Hemostasis
    Integrin cell surface interactions
    Signal Transduction
    Basigin interactions
    Cell surface interactions at the vascular wall


    5/9         Kegg Pathways  (Kegg details for ITGA3) (see all 9):
        Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage
    Regulation of actin cytoskeleton
    Pathways in cancer


    ITGA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for ITGA3 (P260062, 3 ENSP000000077224) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDIA3P301012, 3MINT-4301442 I2D: score=1 
    FHL2Q141922, 3, ENSP000003229094MINT-15432 MINT-15431 I2D: score=5 STRING: ENSP00000322909
    LGALS8O002143, ENSP000003095764I2D: score=4 STRING: ENSP00000309576
    CD151P485093, ENSP000003241014I2D: score=3 STRING: ENSP00000324101
    TSPAN4O148173, ENSP000003243044I2D: score=3 STRING: ENSP00000324304
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion TAS1655803
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007596blood coagulation TAS--


    ITGA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITGA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGA3
    4 Novoseek chemical compound relationships for ITGA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 16.6 1 7894073 (1)
    retinoid 15.6 1 8915849 (1)
    tyrosine 0 1 1717976 (1)
    serine 0 1 7945369 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGA3 / ITA3 

    Transcripts
    for ITGA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITGA3 gene (2 alternative transcripts): 
    NM_002204.2  NM_005501.2  

    Unigene Cluster for ITGA3:

    Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
    Hs.265829  [show with all ESTs]
    Unigene Representative Sequence: NM_002204
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506401 ENST00000505306(uc010dbl.3 uc010dbm.3) ENST00000320031
    ENST00000007722 ENST00000508100 ENST00000570989 ENST00000512553 ENST00000505552
    ENST00000510809 ENST00000505612 ENST00000506827 ENST00000507771 ENST00000515147
    ENST00000504417 ENST00000506437 ENST00000514834 ENST00000544892

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA3 (see all 43):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-223 hsa-miR-124 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: ITGA3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA3 (see all 7)
    OriGene shRNA RFP: ITGA3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA3
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA3

    Additional cDNA sequence: 

    AK095140.1 AK289961.1 AK293323.1 AK303384.1 BC015344.1 BC043917.1 BC136636.1 BC144328.1 
    BC150190.1 D01038.1 M59911.1 

    19 DOTS entries:

    DT.100824860  DT.97847933  DT.92459193  DT.100042412  DT.95304537  DT.95329616  DT.91678095  DT.102842887 
    DT.100708481  DT.120949772  DT.120949792  DT.120949798  DT.91844016  DT.95290566  DT.95304474  DT.95304480 
    DT.95304536  DT.97860840  DT.91974466 

    24/578 AceView cDNA sequences (see all 578):

    CA488434 CN482350 CD614202 F02626 BI836691 AW338639 BQ073731 BC043917 
    BC015344 BQ958923 R69418 AK091950 BG164865 AI493178 BQ919472 BG680667 
    BG752716 BU165775 BM552440 CB142419 BI063590 CA488457 T29886 BU541036 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a ·
    SP1:                                            -                       -                       -                                               -               
    SP2:                                            -                       -                       -                                                               
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:        -                       -                                                   
    SP2:        -                       -                                                   
    SP3:        -                       -     -     -     -     -     -     -     -         
    SP4:                                                                                    
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for ITGA3

    Expression
    for ITGA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACTGTAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITGA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbAutopodMesenchymal Condensate CellsBone, Cartilage
    LimbForelimb Dorsal MusclesMononuclear MyocytesSkeletal Muscle
    LimbForelimb Ventral MusclesMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Dorsal MuscleMononuclear MyocytesSkeletal Muscle
    LimbHindlimb Ventral MuscleMononuclear MyocytesSkeletal Muscle
    LimbStylopodMesenchymal Condensate CellsBone, Cartilage
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Skeletal MuscleThoracic Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Epaxial MyotomeMononuclear MyocytesSkeletal Muscle
    SomiteCervical Hypaxial MyotomeMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See ITGA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA3

    SOURCE GeneReport for Unigene cluster: Hs.265829

    UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
    Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms
    are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on
    vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA3 (see all 7): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGA3
    Browse OriGene validated miRNA SYBR primer pairs
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA3

    Orthologs
    for ITGA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ITGA3 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ITGA31 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of more 68.51(n)
    65.06(a)    		   373946  NM_204146.1  NP_989477.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ITGA36
    		 --
    		 59(a)
    		 1 ↔ 1
    		 6(77231145-77253236)
    African clawed frog
    (Xenopus laevis)    		 Amphibia itga3-A2 integrin alpha 3 subunit 74.13(n)    L43057.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii itga3b1 integrin, alpha 3b 55.16(n)
    47.89(a)    		   100331874  NM_001190309.1  NP_001177238.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mew3 wing morphogenesis cell adhesion receptor 29(a)
    (best of 2)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea ina-13 Integrin alpha chain 27(a)   III(9240086-9244462)   --


    ENSEMBL Gene Tree for ITGA3 (if available)
    TreeFam Gene Tree for ITGA3 (if available) 

    Paralogs
    for ITGA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA3 gene
    ITGA12  ITGA62  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    7 SIMAP similar genes for ITGA3 using alignment to 7 protein entries:     ITA3_HUMAN (see all proteins):
    ITGA2B    ITGA9    ITGA4    ITGA10    ITGA6    ITGA7
    ITGA7 variant protein

    ITGA3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ITGA3
    PGOHUM00000248171


    Genomic Variants
    for ITGA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/743 NCBI SNPs in ITGA3 are shown (see all 743)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2010604991,2
    		C,other48155460(+) ACAAGA/C/GGACCT 6 R S syn1 mis10--------
    rs98900771,2
    		C,F,A,H,--48131460(+) AGAGCA/GCCCCA 3 -- us2k1 int1 tfbs317Minor allele frequency- G:0.30NS EA NA WA CSA 1210
    rs1390459221,2
    		--48131627(+) GCCTCA/GTTTTT 3 -- us2k1 int10--------
    rs570661511,2
    		C,--48131632(+) ATTTTT/CCTCGT 3 -- us2k1 int17Minor allele frequency- C:0.31WA CSA NA EA 363
    rs1159430601,2
    		C,--48131641(+) GTTTTA/GAAACA 3 -- us2k1 int10--------
    rs1899339431,2
    		--48131646(+) AAAACA/GGAGAT 3 -- us2k1 int10--------
    rs1153611431,2
    		--48131647(+) AAACAG/CAGATA 3 -- us2k1 int11Minor allele frequency- C:0.01WA 118
    rs1136875651,2
    		--48131798(+) AGGGTG/AGCTCA 3 -- us2k1 int11Minor allele frequency- A:0.50CSA 2
    rs1857981501,2
    		--48131843(+) GTGGAG/TCACGA 3 -- us2k1 int10--------
    rs19815161,2
    		C,F,A,--48131919(-) TGCCCG/AGCTAA 3 -- us2k1 int13Minor allele frequency- A:0.33NA WA 6

    HapMap Linkage Disequilibrium report for ITGA3 (48133332 - 48167849 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ITGA3: --
    Human Gene Mutation Database (HGMD): ITGA3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITGA3
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA3

    Disorders / Diseases
    for ITGA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITGA3 for disorders           About GeneDecksing

    OMIM gene information: 605025    OMIM disorders: --

    UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
  • Defects in ITGA3 are the cause of interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa,
    • congenital (ILNEB) [MIM:614748]. A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial
    lung disease, and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts
    for the lethal course of the disease

    20/65 diseases for ITGA3 (see all 65):    About MalaCards
    focal segmental glomerulosclerosis    lichen planus    oral lichen planus    erythema multiforme
    myocardial infarction    oral squamous cell carcinoma    acute myocardial infarction    squamous cell carcinoma
    hydrocele    pancreatic ductal adenocarcinoma    hearing loss    glomerulosclerosis
    basal cell carcinoma    chronic lymphocytic leukemia    small cell carcinoma    lymphocytic leukemia
    glanders    kaposi's sarcoma    thrombophilia    fibrosarcoma

    10/14 Novoseek disease relationships for ITGA3 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 25.8 1 19674850 (1)
    tumors 21.7 10 11115543 (2), 8178927 (1), 8548871 (1), 7518760 (1) (see all 6)
    metastasis 21.2 1 11115543 (1)
    melanoma 20.9 2 10487289 (1), 7628538 (1)
    carcinoma 19.6 1 9713359 (1)
    fibrosarcoma 16.3 2 8125150 (1), 7518760 (1)
    carcinoma basal cell 14.4 2 2033490 (1), 9598011 (1)
    adenocarcinoma 7.65 3 16489176 (1), 12680208 (1), 19674850 (1)
    colon cancer 0 2 11115543 (2)
    cancer lung 0 2 19674850 (1)

    Genetic Association Database (GAD): ITGA3
    Human Genome Epidemiology (HuGE) Navigator: ITGA3 (13 documents)

    Export disorders for ITGA3 gene to outside databases

    Publications
    for ITGA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA3 gene, integrated from 9 sources (see all 256):
    (articles sorted by number of sources associating them with ITGA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. (PubMed id 1655803)1, 2, 3, 9 Takada Y.... Hemler M.E. (1991)
    2. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. (PubMed id 1714443)1, 2, 9 Tsuji T.... Osawa T. (1991)
    3. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. (PubMed id 9111516)1, 2, 9 de Melker A.A.... Sonnenberg A. (1997)
    4. Integrin a3 mutations with kidney, lung, and skin dise ase. (PubMed id 22512483)1, 2 Has C....Laube G.F. (2012)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Association of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients. (PubMed id 15346842)1, 4 Ni Y....Lei L. (2004)
    7. Prognosis of young ischemic stroke in Taiwan: impact of prothrombotic genetic polymorphisms. (PubMed id 15351855)1, 4 Yeh P.S....Ke D.S. (2004)
    8. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. (PubMed id 15181153)1, 2 Fukushi J.... Stallcup W.B. (2004)
    9. Genetic polymorphisms associated with thrombophilia and vascular disease in women with unexplained late intrauterine fetal death: a multicenter study. (PubMed id 14706682)1, 4 Hefler L....Tempfer C. (2004)
    10. Effect of glycoprotein IIIa PlA2 polymorphism on outcome of patients with stable coronary artery disease and effect of smoking. (PubMed id 15194015)1, 4 Lopes N.H....Krieger J.E. (2004)

    External Searches for ITGA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITGA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3675 HGNC: 6139 AceView: ITGA3 Ensembl:ENSG00000005884 euGenes: HUgn3675
    ECgene: ITGA3 Kegg: 3675 H-InvDB: ITGA3

    Other Databases showing ITGA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ITGA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ITGA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITGA3 gene:
    Search GeneIP for patents involving ITGA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ITGA3 gene

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    About This Section

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