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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA3 Gene

protein-coding   GIFtS: 68
GCID: GC17P048133

Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3...

(Previous name: antigen identified by monoclonal antibody J143)
(Previous symbol: MSK18)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 3 (Antigen CD49C, Alpha 3 Subunit Of VLA-3
Receptor)1 2
     GAP-B32
MSK181 2 3     ILNEB2
GAPB32 3 5     VCA-22
Antigen Identified By Monoclonal Antibody J1431 2     VL3A2
Galactoprotein B32 3     VLA3a2
FRP-22 3     Integrin Alpha-32
CD49 Antigen-Like Family Member C2 3     Very Late Activation Protein 3 Receptor, Alpha-3 Subunit2
VLA-3 Subunit Alpha2 3     CD49c Antigen3
CD49C2 5     

External Ids:    HGNC: 61391   Entrez Gene: 36752   Ensembl: ENSG000000058847   OMIM: 6050255   UniProtKB: P260063   

Export aliases for ITGA3 gene to outside databases

Previous GC identifers: GC17P047940 GC17P050613 GC17P048475 GC17P048608 GC17P045488 GC17P043500


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA3 Gene:
The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane
proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene
encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield
disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with
many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have
been identified for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for ITGA3 Gene: 
ITGA3 (integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)) is a protein-coding gene. Diseases associated with ITGA3 include hydrocele, and erythema multiforme, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include protein binding and metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
Function: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and
CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration

Gene Wiki entry for ITGA3 (CD49c) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA3 gene promoter:
         GR   STAT5B   Sp1   GR-beta   STAT1beta   AP-4   Nkx2-5   HEN1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.33

ITGA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P048133:  view genomic region     (about GC identifiers)

Start:
48,133,332 bp from pter      End:
48,167,849 bp from pter
Size:
34,518 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006 (See protein sequence)
Recommended Name: Integrin alpha-3 precursor  
Size: 1051 amino acids; 116612 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: A7E246 B7ZM80 B9EGQ1 D3DTX4 D3DTX5
Alternative splicing: 2 isoforms:  P26006-2   P26006-1   

Explore the universe of human proteins at neXtProt for ITGA3: NX_P26006

Explore proteomics data for ITGA3 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol
    12-myristate 13-acetate stimulation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P26006

  • ITGA3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002195.1  NP_005492.1  

    ENSEMBL proteins: 
     ENSP00000422826   ENSP00000315190   ENSP00000007722   ENSP00000466652   ENSP00000425980  
     ENSP00000426142   ENSP00000467851   ENSP00000446133  
    Reactome Protein details: P26006
    Human Recombinant Protein Products for ITGA3: 
    EMD Millipore Purified and/or Recombinant ITGA3 Protein
    R&D Systems Recombinant & Natural Proteins for ITGA3 (Integrin alpha 3 beta 1/VLA-3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ITGA3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ITGA3
    GenScript Custom Purified and Recombinant Proteins Services for ITGA3
    Novus Biologicals ITGA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009986cell surface IDA--
    GO:0016323basolateral plasma membrane IEA--
    GO:0045202synapse IEA--

    ITGA3 for ontologies           About GeneDecksing



    ITGA3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA3
    R&D Systems Antibodies for ITGA3 (Integrin alpha 3/CD49c)
    Browse OriGene Antibodies
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    GenScript Custom Superior Antibodies Services for ITGA3
    Novus Biologicals ITGA3 Antibodies
    Abcam antibodies for ITGA3
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ITGA3
    LSBio Antibodies in human, mouse, rat for ITGA3 

    Assay Products for ITGA3: 
    EMD Millipore Kits and Assays for the Analysis of ITGA3
    OriGene Custom Assay Services for ITGA3
    R&D Systems Proteome Profiler Antibody Arrays for ITGA3 (Integrin alpha 3/CD49c)
    GenScript Custom Assay Services for ITGA3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    4 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p

    Graphical View of Domain Structure for InterPro Entry P26006

    ProtoNet protein and cluster: P26006

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA3_HUMAN, P26006
    Function: Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and
    CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration

         Genatlas biochemistry entry for ITGA3:
    integrin,alpha 3,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB1 in fibronectin,laminin,collagen receptors

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14676841
    GO:0046872metal ion binding IEA--
         
    ITGA3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ITGA3:
     Decreased TP53 protein express  Decreased focal adhesion (FA)   Increased HPV18 LCR reporter a 

         15 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itga3):
     behavior/neurological  cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  integument  limbs/digits/tail 
     mortality/aging  nervous system  renal/urinary system  respiratory system  vision/eye 

    ITGA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itga3tm1Jak for ITGA3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA3
    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA3 (see all 43):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-223 hsa-miR-124 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidITGA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA3
    Sirion Biotech Customized adenovirus for overexpression of ITGA3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGA3 (see all 13)
    OriGene ORF clones in mouse, rat for ITGA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ITGA3 (NM_005501)
    Sino Biological Human cDNA Clone for ITGA3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA3
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA3 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA3 

    Cell Line
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    Search LifeMap BioReagents cell lines for ITGA3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA3 About   (see all 33)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for ITGA3
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA3 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for ITGA3
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Integrin-mediated cell adhesion and migration

    5/7 BioSystems Pathways for ITGA3 (see all 7)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    IL23-mediated signaling events
    CXCR4-mediated signaling events


    5        Reactome Pathways for ITGA3
        Hemostasis
    Integrin cell surface interactions
    Signal Transduction
    Basigin interactions
    Cell surface interactions at the vascular wall


    5/10         Kegg Pathways  (Kegg details for ITGA3) (see all 10):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage
    Regulation of actin cytoskeleton


    ITGA3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for ITGA3 (P260062, 3 ENSP000000077224) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FHL2Q141922, 3, ENSP000003229094MINT-15432 MINT-15431 I2D: score=5 STRING: ENSP00000322909
    PDIA3P301012, 3MINT-4301442 I2D: score=1 
    ITGB1P055563, ENSP000003640944I2D: score=8 STRING: ENSP00000364094
    CD151P485093, ENSP000003241014I2D: score=3 STRING: ENSP00000324101
    TIMP2P160353, ENSP000002627684I2D: score=3 STRING: ENSP00000262768
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion TAS1655803
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007596blood coagulation TAS--

    ITGA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGA3 (ITA3)

    4 Novoseek inferred chemical compound relationships for ITGA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 16.6 1 7894073 (1)
    retinoid 15.6 1 8915849 (1)
    tyrosine 0 1 1717976 (1)
    serine 0 1 7945369 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGA3 / ITA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA3 gene (2 alternative transcripts): 
    NM_002204.2  NM_005501.2  

    Unigene Cluster for ITGA3:

    Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
    Hs.265829  [show with all ESTs]
    Unigene Representative Sequence: NM_002204
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506401 ENST00000505306(uc010dbl.3 uc010dbm.3) ENST00000320031
    ENST00000007722 ENST00000508100 ENST00000570989 ENST00000512553 ENST00000505552
    ENST00000510809 ENST00000505612 ENST00000506827 ENST00000507771 ENST00000515147
    ENST00000504417 ENST00000506437 ENST00000514834 ENST00000544892
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA3 (see all 43):
    hsa-miR-300 hsa-miR-199a-3p hsa-miR-139-5p hsa-miR-624* hsa-miR-486-3p hsa-miR-223 hsa-miR-124 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidITGA3 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA3

    Additional mRNA sequence: 

    AK095140.1 AK289961.1 AK293323.1 AK303384.1 BC015344.1 BC043917.1 BC136636.1 BC144328.1 
    BC150190.1 D01038.1 M59911.1 

    19 DOTS entries:

    DT.100824860  DT.97847933  DT.92459193  DT.100042412  DT.95304537  DT.95329616  DT.91678095  DT.102842887 
    DT.100708481  DT.120949772  DT.120949792  DT.120949798  DT.91844016  DT.95290566  DT.95304474  DT.95304480 
    DT.95304536  DT.97860840  DT.91974466 

    24/578 AceView cDNA sequences (see all 578):

    BQ891699 BQ222520 CB131111 BG680667 CB306966 BQ918770 BQ958923 CB143053 
    BG752716 AK095140 CB142419 AW247291 BU527785 CA415758 CA488457 BI836691 
    BG163308 BQ932054 CA489607 CA487327 R55537 CB141168 BQ073731 CB150198 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA3 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a ·
    SP1:                                            -                       -                       -                                               -               
    SP2:                                            -                       -                       -                                                               
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24 ^ 25
    SP1:        -                       -                                                   
    SP2:        -                       -                                                   
    SP3:        -                       -     -     -     -     -     -     -     -         
    SP4:                                                                                    
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for ITGA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA3 expression in normal human tissues (normalized intensities)      ITGA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACTGTAGC
    ITGA3 Expression
    About this image


    ITGA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 20 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Somite (Muscoskeletal System)    fully expand to see all 16 entries
             Mononuclear Myocytes Cervical Primary Hypaxial Myotome
     
     Limb (Muscoskeletal System)    fully expand to see all 9 entries
             Mesenchymal Condensate Cells Zeugopod
             limb/forelimb   
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             brain/hindbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Mesenchymal Condensate Cells Zeugopod
             sensory organ/ear/inner ear   

    See ITGA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA3

    SOURCE GeneReport for Unigene cluster: Hs.265829

    UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
    Tissue specificity: Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both
    isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly
    expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA3 (see all 7): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Wound Healing in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ITGA3 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga31 , 5 integrin alpha 31, 5 85.14(n)1
    86.26(a)1
      11 (59.01 cM)5
    164001  NM_013565.21  NP_038593.11 
     950444745 
    chicken
    (Gallus gallus)
    Aves ITGA31 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of more 68.51(n)
    65.06(a)
      373946  NM_204146.1  NP_989477.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA36
    integrin, alpha 3 (antigen CD49C, alpha 3 subunit ...
    60(a)
    1 ↔ 1
    6(77195620-77265779)
    African clawed frog
    (Xenopus laevis)
    Amphibia itga3-A2 integrin alpha 3 subunit 74.13(n)    L43057.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itga3b1 integrin, alpha 3b 55.16(n)
    47.89(a)
      100331874  NM_001190309.1  NP_001177238.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mew3 wing morphogenesis cell adhesion
    receptor
    29(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea ina-13 Integrin alpha chain 27(a)   III(9240086-9244462)   --


    ENSEMBL Gene Tree for ITGA3 (if available)
    TreeFam Gene Tree for ITGA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA3 gene
    ITGA12  ITGA62  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  
    7 SIMAP similar genes for ITGA3 using alignment to 7 protein entries:     ITA3_HUMAN (see all proteins):
    ITGA2B    ITGA9    ITGA4    ITGA10    ITGA7    ITGA7 variant protein
    ITGA6

    ITGA3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ITGA3
    PGOHUM00000248171


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1015 SNPs in ITGA3 are shown (see all 1015)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0688084
    Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB)4--see VAR_0688082 R P mis40--------
    rs2010604991,2
    Cuntested149168734(+) ACAAGA/C/GGACCT 4 R syn10--------
    rs1821013921,2
    --43498537(+) GGCAGA/GTAACC 2 -- us2k10--------
    rs1507332551,2
    --43498557(+) TCTGTC/TTTCTC 2 -- us2k10--------
    rs1135694381,2
    C,F--48150968(+) CACACG/ACACAC 2 -- int12Minor allele frequency- A:0.50CSA 4
    rs32168951,2
    C--48153906(-) CACCA-/CCCCCCCC 2 -- int10--------
    rs20181341,2
    C,F,A--48157869(-) AAATCA/TCACAC 2 -- int19Minor allele frequency- T:0.12NA PA CSA WA EA 616
    rs1130890191,2
    C--48159836(+) GTGCCC/TGGCCT 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs358331651,2
    C--48160223(+) CTTCC-/CACCCA 2 -- int10--------
    rs711469621,2
    C--48163574(+) GTATA-/AT/TATATATTAGATTA
    TATATATTATACATGTATAA
    ATATA
    2 -- int11NA 2

    HapMap Linkage Disequilibrium report for ITGA3 (48133332 - 48167849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ITGA3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509660CNV Insertion20534489
    esv993321CNV Insertion20482838
    esv1740779CNV Insertion17803354
    nsv833474CNV Loss17160897
    dgv3226n71CNV Loss21882294
    nsv908588CNV Loss21882294
    dgv3225n71CNV Loss21882294
    nsv908590CNV Loss21882294


    Human Gene Mutation Database (HGMD): ITGA3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA3
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605025    OMIM disorders: --

    UniProtKB/Swiss-Prot: ITA3_HUMAN, P26006
  • Interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital (ILNEB)
    [MIM:614748]: A multiorgan disorder characterized by congenital nephrotic syndrome, interstitial lung disease,
    and epidermolysis bullosa. The respiratory and renal features predominate, and lung involvement accounts for the
    lethal course of the disease. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 20/61 diseases for ITGA3 (see all 61):    About MalaCards
    hydrocele    erythema multiforme    glanders    focal segmental glomerulosclerosis
    oral lichen planus    fibrosarcoma    thrombophilia    lichen planus
    small cell carcinoma    epidermolysis bullosa    pancreatic ductal adenocarcinoma    hernia
    seminoma    proteinuria    interstitial lung disease    gout
    tonsillitis    bladder carcinoma    kaposi's sarcoma    basal cell carcinoma


    ITGA3 for disorders           About GeneDecksing

    10/14 Novoseek inferred disease relationships for ITGA3 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma squamous cell 25.8 1 19674850 (1)
    tumors 21.7 10 11115543 (2), 8178927 (1), 8548871 (1), 7518760 (1) (see all 6)
    metastasis 21.2 1 11115543 (1)
    melanoma 20.9 2 10487289 (1), 7628538 (1)
    carcinoma 19.6 1 9713359 (1)
    fibrosarcoma 16.3 2 8125150 (1), 7518760 (1)
    carcinoma basal cell 14.4 2 2033490 (1), 9598011 (1)
    adenocarcinoma 7.65 3 16489176 (1), 12680208 (1), 19674850 (1)
    colon cancer 0 2 11115543 (2)
    cancer lung 0 2 19674850 (1)

    Genetic Association Database (GAD): ITGA3
    Human Genome Epidemiology (HuGE) Navigator: ITGA3 (13 documents)

    Export disorders for ITGA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA3 gene, integrated from 9 sources (see all 265):
    (articles sorted by number of sources associating them with ITGA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. (PubMed id 1655803)1, 2, 3, 9 Takada Y.... Hemler M.E. (1991)
    2. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3. (PubMed id 1714443)1, 2, 9 Tsuji T.... Osawa T. (1991)
    3. The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. (PubMed id 9111516)1, 2, 9 de Melker A.A.... Sonnenberg A. (1997)
    4. Integrin a3 mutations with kidney, lung, and skin dise ase. (PubMed id 22512483)1, 2 Has C....Laube G.F. (2012)
    5. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (2009)
    6. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    7. Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. (PubMed id 18384059)1, 4 Kahler A.K....Andreassen O.A. (2008)
    8. Polymorphisms in predicted microRNA binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. (PubMed id 18550570)1, 4 Brendle A....Forsti A. (2008)
    9. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3675 HGNC: 6139 AceView: ITGA3 Ensembl:ENSG00000005884 euGenes: HUgn3675
    ECgene: ITGA3 Kegg: 3675 H-InvDB: ITGA3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA3 gene:
    Search GeneIP for patents involving ITGA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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