Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ITGA2B Gene

protein-coding   GIFtS: 72
GCID: GC17M042460

Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa...

(Previous names: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa...)
(Previous symbol: GP2B)
  See ITGA2B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex,
Antigen CD41)1 2
     Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen
CD41B)1
GP2B1 2 3 5     CD412
Platelet Membrane Glycoprotein IIb2 3     GTA2
GPIIb2 3     HPA32
GPalpha IIb2 3     Integrin Alpha-IIb2
BDPLT162 5     Platelet Fibrinogen Receptor, Alpha Subunit2
BDPLT22 5     Platelet-Specific Antigen BAK2
CD41B2 5     ITGAB3
GT2 5     CD41 Antigen3

External Ids:    HGNC: 61381   Entrez Gene: 36742   Ensembl: ENSG000000059617   OMIM: 6077595   UniProtKB: P085143   

Export aliases for ITGA2B gene to outside databases

Previous GC identifers: GC17M042191 GC17M044626 GC17M042924 GC17M039805 GC17M038213


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ITGA2B Gene:
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an
alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked
light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a
crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to
adhesion, integrins are known to participate in cell-surface mediated signalling. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA2B Gene:
ITGA2B (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)) is a protein-coding gene. Diseases associated with ITGA2B include thrombasthenia, and bleeding disorder, platelet-type, 16, autosomal dominant. GO annotations related to this gene include extracellular matrix binding and identical protein binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin,
thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the
sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3
brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid
platelet aggregation which physically plugs ruptured endothelial cell surface

summary for ITGA2B Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA2B gene promoter:
         AML1a   Nkx2-5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA2B promoter sequence
   Search Chromatin IP Primers for ITGA2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.32

ITGA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA2B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042460:  view genomic region     (about GC identifiers)

Start:
42,449,548 bp from pter      End:
42,466,873 bp from pter
Size:
17,326 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514 (See protein sequence)
Recommended Name: Integrin alpha-IIb precursor  
Size: 1039 amino acids; 113377 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts with CIB1
Selected PDB 3D structures from and Proteopedia for ITGA2B (see all 36):
1DPK (3D)        1DPQ (3D)        1JX5 (3D)        1KUP (3D)        1KUZ (3D)        1M8O (3D)    
Secondary accessions: B2RCY8 O95366 Q14443 Q17R67
Alternative splicing: 3 isoforms:  P08514-1   P08514-2   P08514-3   

Explore the universe of human proteins at neXtProt for ITGA2B: NX_P08514

Explore proteomics data for ITGA2B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn46, Asn280, Asn601, Asn711, Ile874, Ser878, Asn962
  • Modification sites at PhosphoSitePlus

  • See ITGA2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000410.2  
    ENSEMBL proteins: 
     ENSP00000465534   ENSP00000467269   ENSP00000262407   ENSP00000340536   ENSP00000366268  
    Reactome Protein details: P08514

    ITGA2B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA2B (Integrin alpha 2b beta 3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA2B
    OriGene Protein Over-expression Lysate for ITGA2B
    OriGene MassSpec for ITGA2B
    OriGene Custom Protein Services for ITGA2B
    GenScript Custom Purified and Recombinant Proteins Services for ITGA2B
    Novus Biologicals ITGA2B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA2B 

     
    Search antibodies-online for proteins for ITGA2B 

     
    antibodies-online peptides for ITGA2B

    ITGA2B Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA2B
    R&D Systems Antibodies for ITGA2B (Integrin alpha 2b/CD41)
    Cell Signaling Technology (CST) Antibodies for ITGA2B 
    OriGene Antibodies for ITGA2B
    OriGene Custom Antibody Services for ITGA2B
    Novus Biologicals ITGA2B Antibodies
    Abcam antibodies for ITGA2B
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ITGA2B
    antibodies-online antibodies for ITGA2B 

    ITGA2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGA2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ITGA2B 
    antibodies-online kits for ITGA2B (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P08514

    ProtoNet protein and cluster: P08514

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    Find genes that share domains with ITGA2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA2B_HUMAN, P08514
    Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin,
    thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the
    sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3
    brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid
    platelet aggregation which physically plugs ruptured endothelial cell surface

         Genatlas biochemistry entry for ITGA2B:
    integrin,alpha 2B,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB3 in fibrinogen,fibronectin,von Willebrand factor,vitronectin,thrombospondin receptors

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14681217
    GO:0042802identical protein binding IPI11606749
    GO:0046872metal ion binding IEA--
    GO:0050840extracellular matrix binding IEA--
    GO:0070051fibrinogen binding IEA--
         
    Find genes that share ontologies with ITGA2B           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGA2B:
     Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Itga2b):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  reproductive system 

    Find genes that share phenotypes with ITGA2B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itga2btm1Tlr for ITGA2B

       genOway: Develop your customized and physiologically relevant rodent model for ITGA2B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ITGA2B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITGA2B
    SwitchGear 3'UTR luciferase reporter plasmidITGA2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA2B
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA2B

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA2B (see all 6)
    OriGene ORF clones in mouse, rat for ITGA2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA2B (NM_000419)
    Sino Biological Human cDNA Clone for ITGA2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2B
    Addgene plasmids for ITGA2B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA2B
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA2B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ITA2B_HUMAN, P08514: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    plasma membrane4
    cytoskeleton2
    nucleus2
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS2439501
    GO:0005925focal adhesion IEA--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--

    Find genes that share ontologies with ITGA2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ITGA2B About   (see all 38)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5Integrin alphaIIb beta3 signaling
    Integrin alphaIIb beta3 signaling0.73
    GRB2-SOS provides linkage to MAPK signaling for Intergrins0.00
    Platelet Aggregation (Plug Formation)0.73
    p130Cas linkage to MAPK signaling for integrins0.00


    Find genes that share SuperPaths with ITGA2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGA2B
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA2B (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ITGA2B
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ITGA2B
        Cell adhesion Integrin inside-out signaling

    Selected BioSystems Pathways for ITGA2B (see all 6)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Arf6 signaling events
    Signaling events mediated by PTP1B


    Selected Reactome Pathways for ITGA2B (see all 7)
        ECM proteoglycans
    Signal transduction by L1
    Integrin cell surface interactions
    Platelet degranulation
    Integrin alphaIIb beta3 signaling

    1 PharmGKB Pathway for ITGA2B
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ITGA2B) (see all 11):
        Rap1 signaling pathway
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA2B: 
              Osteogenesis in human mouse rat
              Focal Adhesions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA2B (P085141, 2, 3 ENSP000002624074) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB3P051061, 2, 3EBI-702693,EBI-702847 MINT-7261298 MINT-7261237 MINT-7261175 MINT-7261217 MINT-7261198 MINT-7261279 MINT-7261157 MINT-7261259 I2D: score=6 
    COL2A1P024583, ENSP000003698894I2D: score=3 STRING: ENSP00000369889
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    CALRP277973, ENSP000003208664I2D: score=2 STRING: ENSP00000320866
    CD36P166713, ENSP000003081654I2D: score=2 STRING: ENSP00000308165
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0007155cell adhesion TAS10429193
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    Find genes that share ontologies with ITGA2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ITGA2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    2 DrugBank Compounds for ITGA2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tirofiban-- 144494-65-5targetantagonist11342206 11929319 12057986 11076818 11565896 20210689
    Abciximab7E3 (see all 4)143653-53-6targetantagonist18510478 12749745 19499855

    Selected Novoseek inferred chemical compound relationships for ITGA2B gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 74.9 42 8191392 (4), 7566578 (3), 1705115 (2), 9227689 (2) (see all 29)
    adp 59.8 11 16769603 (1), 20305399 (1), 7794942 (1), 17869981 (1)
    12-o-tetradecanoylphorbol 13-acetate 30.3 3 1893970 (2), 1779468 (1)
    gf 109203x 20.7 1 8547633 (1)
    abciximab 20 2 11224490 (1), 16261288 (1)
    arachidonic acid 18.1 2 20305399 (1)
    isoleucine 5.13 1 2350579 (1)
    lysine 0 2 1744141 (1), 11122161 (1)
    cytosine 0 2 15886807 (1), 11091187 (1)
    calcium 0 15 8916916 (4), 2039481 (2), 16431050 (1), 7508443 (1) (see all 7)



    Find genes that share compounds with ITGA2B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ITGA2B gene: 
    NM_000419.3  

    Unigene Cluster for ITGA2B:

    Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
    Hs.411312  [show with all ESTs]
    Unigene Representative Sequence: NM_000419
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588098 ENST00000587295 ENST00000262407(uc002igt.1 uc002igu.1)
    ENST00000592462 ENST00000592226 ENST00000591990 ENST00000589645 ENST00000592075
    ENST00000592253 ENST00000592944 ENST00000353281 ENST00000377068
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA2B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ITGA2B
    SwitchGear 3'UTR luciferase reporter plasmidITGA2B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ITGA2B
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA2B
    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA2B (see all 6)
    OriGene ORF clones in mouse, rat for ITGA2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA2B (NM_000419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2B
    Addgene plasmids for ITGA2B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA2B
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA2B
      QuantiFast Probe-based Assays in human, mouse, rat ITGA2B

    Additional mRNA sequence: 

    AF098114.1 AK297155.1 AK303081.1 AK315335.1 BC117443.1 BC126442.1 DQ841705.1 J02764.1 
    M18085.1 M34480.1 X06831.1 

    6 DOTS entries:

    DT.410560  DT.75171864  DT.95158168  DT.100653263  DT.120970941  DT.121645427 

    Selected AceView cDNA sequences (see all 99):

    BI821446 BX116497 R28994 AF098114 AW204899 BF513348 BM920426 BM145891 
    BQ068277 M18085 BC030200 J02764 CA433534 BE018845 BX281671 NM_000419 
    AI479375 BI909264 AW997241 AW513968 AI991183 BI918426 BX333935 BI824672 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -           -                                                     -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                          -                           
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ITGA2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ITGA2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGGTCG
    ITGA2B Expression
    About this image


    ITGA2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 10 entries
             Megakaryocytes Hematopoietic Bone Marrow
             Megakaryocytes-like cells
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 2 entries
             Erythroid Progenitor Cells Definitive Yolk Sac
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)
             Primitive Erythrocytes Extraembryonic Blood Islands
     
     Thymus (Hematopoietic System)
             Hematopoietic Stem Cells Thymus
     
     Liver (Hepatobiliary System)
             Liver Lobule
    ITGA2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411312

    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
    Tissue specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in
    reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate
    adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA2B: 
              Osteogenesis in human mouse rat
              Focal Adhesions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA2B
    QuantiTect SYBR Green Assays in human, mouse, rat ITGA2B
    QuantiFast Probe-based Assays in human, mouse, rat ITGA2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ITGA2B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga2b1 , 5 integrin alpha 2b1, 5 82.47(n)1
    81.05(a)1
      11 (66.29 cM)5
    163991  NM_010575.21  NP_034705.21 
     1024532975 
    chicken
    (Gallus gallus)
    Aves ITGA2B6
    integrin, alpha 2b (platelet glycoprotein IIb of I...
    55(a)
    1 ↔ 1
    JH375701.1(21-1625)
    lizard
    (Anolis carolinensis)
    Reptilia ITGA2B6
    integrin, alpha 2b (platelet glycoprotein IIb of I...
    48(a)
    1 ↔ 1
    6(64000512-64058099)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itga2b.11 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), gene 1 less 53.18(n)
    47.46(a)
      100158580  XM_004918645.1  XP_004918702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itga2b1 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) less 52.5(n)
    44.22(a)
      445380  NM_001003857.1  NP_001003857.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaPS43 cell-matrix adhesion cell adhesion
    receptor
    27(a)
    (best of 3)
      51E11   --
    worm
    (Caenorhabditis elegans)
    Secernentea pat-26
    Protein PAT-2 (pat-2) mRNA, complete cds
    24(a)
    1 → many
    III(8818902-8825270) WBGene00003929


    ENSEMBL Gene Tree for ITGA2B (if available)
    TreeFam Gene Tree for ITGA2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ITGA2B gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    7 SIMAP similar genes for ITGA2B using alignment to 8 protein entries:     ITA2B_HUMAN (see all proteins):
    ITGA3    ITGA7    ITGA8    ITGA4    ITGA5    ITGAV
    ITGA9

    Find genes that share paralogs with ITGA2B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    ITA2B_HUMAN, P08514: Position 874 is associated with platelet-specific alloantigen HPA-3/BAK/LEK. HPA-3A/BAK(A)/LEK(A)
    has Ile-874 and HPA-3B/BAK(B)/LEK(B) has Ser-874. HPA-3B is involved in neonatal alloimmune thrombocytopenia
    (NAIT or NATP)


    Selected SNPs for ITGA2B (see all 596)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0304514
    Glanzmann thrombasthenia (GT)4--see VAR_0304512 L P mis40--------
    VAR_0304664
    Glanzmann thrombasthenia (GT)4--see VAR_0304662 V M mis40--------
    VAR_0039824
    Glanzmann thrombasthenia (GT)4--see VAR_0039822 Q P mis40--------
    VAR_0304604
    Glanzmann thrombasthenia (GT)4--see VAR_0304602 I T mis40--------
    VAR_0304624
    Glanzmann thrombasthenia (GT)4--see VAR_0304622 L V mis40--------
    VAR_0304484
    Glanzmann thrombasthenia (GT)4--see VAR_0304482 Y H mis40--------
    VAR_0304574
    Glanzmann thrombasthenia (GT)4--see VAR_0304572 G R mis40--------
    VAR_0304564
    Glanzmann thrombasthenia (GT)4--see VAR_0304562 I T mis40--------
    VAR_0304454
    Glanzmann thrombasthenia (GT)4--see VAR_0304452 L P mis40--------
    VAR_0098864
    Glanzmann thrombasthenia (GT)4--see VAR_0098862 P L mis40--------

    HapMap Linkage Disequilibrium report for ITGA2B (42449548 - 42466873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ITGA2B:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3175n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): ITGA2B
    Locus Specific Mutation Databases (LSDB): ITGA2B

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA2B
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607759   
    OMIM disorders: 273800  187800  
    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
  • Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is
    characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into
    types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and
    lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at
    reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital
    macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected
    individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet
    functional abnormalities. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 18 diseases for ITGA2B:    
    About MalaCards
    thrombasthenia    bleeding disorder, platelet-type, 16, autosomal dominant    glanzmann's thrombasthenia    thrombocytopenia, neonatal alloimmune, bak antigen related
    thrombasthenia of glanzmann and naegeli, itga2b-related    macrothrombocytopenia, autosomal dominant, tubb1-related    intermediate coronary syndrome    calpainopathy
    fetal and neonatal alloimmune thrombocytopenia    hemorrhagic fever with renal syndrome    arteriovenous fistula    bernard-soulier syndrome
    myelitis    autoimmune thrombocytopenic purpura    purpura    megakaryocytic leukemia
    thrombocytopenia    myocardial infarction

    12 diseases from the University of Copenhagen DISEASES database for ITGA2B:
    Glanzmann's thrombasthenia     Myocardial infarction     Intermediate coronary syndrome     Thrombocytopenia
    Coronary heart disease     Bernard-Soulier syndrome     Cerebrovascular accident     Autoimmune thrombocytopenic purpura
    Atherosclerosis     Von Willebrand's disease     Leukemia     Diabetes mellitus

    Find genes that share disorders with ITGA2B           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ITGA2B gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 94.6 31 1967954 (3), 20020534 (2), 1635160 (1), 7794942 (1) (see all 26)
    bernard-soulier syndrome 73.7 1 8457642 (1)
    posttransfusion purpura 64.1 1 15678278 (1)
    platelet disorder 60.9 1 16793673 (1)
    coagulopathy 58.1 3 1967954 (1), 20020534 (1), 9695977 (1)
    thrombocytopenia 53 4 12724616 (1), 15678278 (1), 15157339 (1), 2301979 (1)
    erythroleukemia 49.6 2 2351656 (1), 10575637 (1)
    autoimmune thrombocytopenia 40 1 15678278 (1)
    purpura thrombocytopenic 39.7 1 7605170 (1)
    leukemia 27.1 2 8750618 (1), 7539513 (1)

    Genatlas disease: ITGA2B
    Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)

    Genetic Association Database (GAD): ITGA2B
    Human Genome Epidemiology (HuGE) Navigator: ITGA2B (65 documents)

    Export disorders for ITGA2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ITGA2B gene, integrated from 10 sources (see all 552):
    (articles sorted by number of sources associating them with ITGA2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Double heterozygosity of the GPIIb gene in a Swiss patient with Glanzmann's thrombasthenia. (PubMed id 9734640)1, 2, 9 Ruan J.... Nurden A.T. (Br. J. Haematol. 1998)
    2. Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. (PubMed id 7706461)1, 2, 9 Wilcox D.A.... Newman P.J. (J. Clin. Invest. 1995)
    3. Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. (PubMed id 8282784)1, 2, 9 Poncz M.... Bennett J.S. (J. Clin. Invest. 1994)
    4. GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. (PubMed id 2345548)1, 2, 9 Frachet P....Marguerie G. (Mol. Biol. Rep. 1990)
    5. Molecular genetic analysis of a compound heterozygote for the glycoprotein (GP) IIb gene associated with Glanzmann's thrombasthenia: disruption of the 674-687 disulfide bridge in GPIIb prevents surface exposure of GPIIb-IIIa complexes. (PubMed id 9920835)1, 2, 9 Gonzalez-Manchon C.... Parrilla R. (Blood 1999)
    6. Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs. (PubMed id 2351656)1, 2, 9 Bray P.F.... Shuman M.A. (J. Biol. Chem. 1990)
    7. Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen system. (PubMed id 2350579)1, 2, 9 Lyman S.... Newman P.J. (Blood 1990)
    8. Organization of the gene for platelet glycoprotein IIb. (PubMed id 2322558)1, 2, 9 Heidenreich R.... Poncz M. (Biochemistry 1990)
    9. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PubMed id 15227729)1, 4, 9 Park S....Jang Y. (Yonsei Med. J. 2004)
    10. Human platelet alloantigens HPA-1, HPA-2, and HPA-3 polymorphisms associated with extent of severe coronary artery disease. (PubMed id 19562259)1, 4, 9 Abboud N....Mahjoub T. (J. Thromb. Thrombolysis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3674 HGNC: 6138 AceView: ITGA2B Ensembl:ENSG00000005961 euGenes: HUgn3674
    ECgene: ITGA2B Kegg: 3674 H-InvDB: ITGA2B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ITGA2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA2B Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ITGA2B[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ITGA2B gene:
    Search GeneIP for patents involving ITGA2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA2B
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for ITGA2B (Integrin alpha 2b/CD41)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for ITGA2B (Integrin alpha 2b beta 3)   Browse Stem Cell Products  
     cDNA Clones for ITGA2B (Integrin alpha 2b/CD41)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ITGA2B   OriGene RNAi products in human, mouse, rat for ITGA2B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ITGA2B  
     OriGene MassSpec for ITGA2B   OriGene clones in human, mouse for ITGA2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for ITGA2B   OriGene Purified Protein for ITGA2B  
     OriGene ORF clones in mouse, rat for ITGA2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ITGA2B   OriGene Custom Protein Services for ITGA2B  

     
     
     Block miRNA regulation of human, mouse, rat ITGA2B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ITGA2B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA2B Predesigned siRNA for gene silencing in human, mouse, rat ITGA2B
     QuantiFast Probe-based Assays in human, mouse, rat ITGA2B QuantiTect SYBR Green Assays in human, mouse, rat ITGA2B
     PCR Arrays including human, mouse, rat ITGA2B Search Chromatin IP Primers for ITGA2B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA2B  GeneGlobe Interaction Network for ITGA2B
     Regulatory tfbs in ITGA2B promoter
     GenScript Custom Purified and Recombinant Proteins Services for ITGA2B GenScript cDNA clones with any tag delivered in your preferred vector for ITGA2B
     GenScript Custom Assay Services for ITGA2B GenScript Custom overexpressing Cell Line Services for ITGA2B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ITGA2B 

     Tocris compounds for ITGA2B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ITGA2B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ITGA2B antibodies
     ITGA2B lysates
     Antibodies for ITGA2B
     See all of Abcam's Antibodies, Kits and Proteins for ITGA2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA2B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2B
     SwitchGear 3'UTR luciferase reporter plasmids for ITGA2B
     SwitchGear Promoter luciferase reporter plasmids for ITGA2B
     ThermoFisher Antibodies for ITGA2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2B
     Browse compounds at ApexBio
     Addgene plasmids for ITGA2B
      Search eBioscience for proteins for ITGA2B
      Search eBioscience for elisas for ITGA2B
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ITGA2B
     antibodies-online antibodies for ITGA2B
     antibodies-online kits for ITGA2B (4 products)
     antibodies-online peptides for ITGA2B
      Search antibodies-online for proteins for ITGA2B
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ITGA2B gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4