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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA2B Gene

protein-coding   GIFtS: 72
GCID: GC17M042460

Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa...

(Previous names: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa...)
(Previous symbol: GP2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex,
Antigen CD41)1 2
     CD412
GP2B1 2 3 5     GT2
Platelet Membrane Glycoprotein IIb2 3     GTA2
GPIIb2 3     HPA32
GPalpha IIb2 3     Integrin Alpha-IIb2
CD41B2 5     Platelet Fibrinogen Receptor, Alpha Subunit2
Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen
CD41B)1
     Platelet-Specific Antigen BAK2
BDPLT162     ITGAB3
BDPLT22     CD41 Antigen3

External Ids:    HGNC: 61381   Entrez Gene: 36742   Ensembl: ENSG000000059617   OMIM: 6077595   UniProtKB: P085143   

Export aliases for ITGA2B gene to outside databases

Previous GC identifers: GC17M042191 GC17M044626 GC17M042924 GC17M039805 GC17M038213


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA2B Gene:
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an
alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked
light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a
crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to
adhesion, integrins are known to participate in cell-surface mediated signalling. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA2B Gene: 
ITGA2B (integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)) is a protein-coding gene. Diseases associated with ITGA2B include thrombasthenia, and glanzmann's thrombasthenia, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include extracellular matrix binding and identical protein binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin,
thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the
sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3
brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid
platelet aggregation which physically plugs ruptured endothelial cell surface

summary for ITGA2B Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA2B gene promoter:
         AML1a   Nkx2-5   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA2B promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.32

ITGA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA2B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M042460:  view genomic region     (about GC identifiers)

Start:
42,449,548 bp from pter      End:
42,466,873 bp from pter
Size:
17,326 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514 (See protein sequence)
Recommended Name: Integrin alpha-IIb precursor  
Size: 1039 amino acids; 113377 Da
Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain
linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181
Subcellular location: Membrane; Single-pass type I membrane protein
6/35 PDB 3D structures from and Proteopedia for ITGA2B (see all 35):
1DPK (3D)        1DPQ (3D)        1JX5 (3D)        1KUP (3D)        1KUZ (3D)        1M8O (3D)    
Secondary accessions: B2RCY8 O95366 Q14443 Q17R67
Alternative splicing: 3 isoforms:  P08514-1   P08514-2   P08514-3   

Explore the universe of human proteins at neXtProt for ITGA2B: NX_P08514

Explore proteomics data for ITGA2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08514

  • ITGA2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA2B Protein Expression
    REFSEQ proteins: NP_000410.2  
    ENSEMBL proteins: 
     ENSP00000465534   ENSP00000467269   ENSP00000262407   ENSP00000340536   ENSP00000366268  
    Reactome Protein details: P08514
    Human Recombinant Protein Products for ITGA2B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA2B (Integrin alpha 2b beta 3)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ITGA2B
    OriGene Protein Over-expression Lysate for ITGA2B
    OriGene MassSpec for ITGA2B 
    OriGene Custom Protein Services for ITGA2B
    GenScript Custom Purified and Recombinant Proteins Services for ITGA2B
    Novus Biologicals ITGA2B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS2439501
    GO:0005925focal adhesion IEA--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--

    ITGA2B for ontologies           About GeneDecksing



    ITGA2B Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA2B
    R&D Systems Antibodies for ITGA2B (Integrin alpha 2b/CD41)
    Cell Signaling Technology (CST) Antibodies for ITGA2B 
    OriGene Antibodies for ITGA2B
    OriGene Custom Antibody Services for ITGA2B
    GenScript Custom Superior Antibodies Services for ITGA2B
    Novus Biologicals ITGA2B Antibodies
    Abcam antibodies for ITGA2B
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ITGA2B
    LSBio Antibodies in human, mouse, rat for ITGA2B 

    Assay Products for ITGA2B: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGA2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P08514

    ProtoNet protein and cluster: P08514

    3 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats


    ITGA2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA2B_HUMAN, P08514
    Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin,
    thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the
    sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3
    brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid
    platelet aggregation which physically plugs ruptured endothelial cell surface

         Genatlas biochemistry entry for ITGA2B:
    integrin,alpha 2B,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB3 in fibrinogen,fibronectin,von Willebrand factor,vitronectin,thrombospondin receptors

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14681217
    GO:0042802identical protein binding IPI11606749
    GO:0046872metal ion binding IEA--
    GO:0050840extracellular matrix binding IEA--
         
    ITGA2B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGA2B:
     Increased circadian period len 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Itga2b):
     cardiovascular system  cellular  digestive/alimentary  embryogenesis  hematopoietic system 
     homeostasis/metabolism  immune system  reproductive system 

    ITGA2B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itga2btm1Tlr for ITGA2B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA2B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA2B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA2B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA2B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ITGA2B
    SwitchGear 3'UTR luciferase reporter plasmidITGA2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA2B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA2B

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of ITGA2B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGA2B (see all 7)
    OriGene ORF clones in mouse, rat for ITGA2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA2B (NM_000419)
    Sino Biological Human cDNA Clone for ITGA2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2B
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA2B 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA2B 

    Cell Line
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    Search LifeMap BioReagents cell lines for ITGA2B
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA2B About   (see all 36)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    ECM proteoglycans0.38
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ITGA2B
        Cell adhesion Integrin inside-out signaling

    1 R&D Systems Pathway for ITGA2B
        Articular Cartilage Extracellular Matrix

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA2B (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    1 Cell Signaling Technology (CST) Pathway for ITGA2B
        Adhesion

    1 GeneGo (Thomson Reuters) Pathway for ITGA2B
        Cell adhesion Integrin inside-out signaling

    5/6 BioSystems Pathways for ITGA2B (see all 6)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Signaling events mediated by PTP1B
    Arf6 signaling events


    5/16        Reactome Pathways for ITGA2B (see all 16)
        Hemostasis
    L1CAM interactions
    Integrin cell surface interactions
    Developmental Biology
    p130Cas linkage to MAPK signaling for integrins

    1 PharmGKB Pathway for ITGA2B
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/10         Kegg Pathways  (Kegg details for ITGA2B) (see all 10):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage
    Regulation of actin cytoskeleton


    ITGA2B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/120 Interacting proteins for ITGA2B (P085141, 2, 3 ENSP000002624074) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB3P051061, 2, 3EBI-702693,EBI-702847 MINT-7261298 MINT-7261237 MINT-7261175 MINT-7261217 MINT-7261198 MINT-7261279 MINT-7261157 MINT-7261259 I2D: score=6 
    COL2A1P024583, ENSP000003698894I2D: score=3 STRING: ENSP00000369889
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    CALRP277973, ENSP000003208664I2D: score=2 STRING: ENSP00000320866
    CD36P166713, ENSP000003081654I2D: score=2 STRING: ENSP00000308165
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0007155cell adhesion TAS10429193
    GO:0007160cell-matrix adhesion IEA--
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007411axon guidance TAS--

    ITGA2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA2B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ITGA2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    2 DrugBank Compounds for ITGA2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tirofiban-- 144494-65-5targetantagonist11342206 11929319 12057986 11076818 11565896 20210689
    Abciximab7E3 (see all 4)143653-53-6targetantagonist18510478 12749745 19499855

    10/13 Novoseek inferred chemical compound relationships for ITGA2B gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 74.9 42 8191392 (4), 7566578 (3), 1705115 (2), 9227689 (2) (see all 29)
    adp 59.8 11 16769603 (1), 20305399 (1), 7794942 (1), 17869981 (1)
    12-o-tetradecanoylphorbol 13-acetate 30.3 3 1893970 (2), 1779468 (1)
    gf 109203x 20.7 1 8547633 (1)
    abciximab 20 2 11224490 (1), 16261288 (1)
    arachidonic acid 18.1 2 20305399 (1)
    isoleucine 5.13 1 2350579 (1)
    lysine 0 2 1744141 (1), 11122161 (1)
    cytosine 0 2 15886807 (1), 11091187 (1)
    calcium 0 15 8916916 (4), 2039481 (2), 16431050 (1), 7508443 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about ITGA2B / ITA2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA2B gene: 
    NM_000419.3  

    Unigene Cluster for ITGA2B:

    Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
    Hs.411312  [show with all ESTs]
    Unigene Representative Sequence: NM_000419
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588098 ENST00000587295 ENST00000262407(uc002igt.1 uc002igu.1)
    ENST00000592462 ENST00000592226 ENST00000591990 ENST00000589645 ENST00000592075
    ENST00000592253 ENST00000592944 ENST00000353281 ENST00000377068
    miRNA
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    OriGene ORF clones in mouse, rat for ITGA2B
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    GenScript: all cDNA clones in your preferred vector: ITGA2B (NM_000419)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2B
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA2B 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA2B 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA2B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA2B

    Additional mRNA sequence: 

    AF098114.1 AK297155.1 AK303081.1 AK315335.1 BC117443.1 BC126442.1 DQ841705.1 J02764.1 
    M18085.1 M34480.1 X06831.1 

    6 DOTS entries:

    DT.410560  DT.75171864  DT.95158168  DT.100653263  DT.120970941  DT.121645427 

    24/99 AceView cDNA sequences (see all 99):

    J02764 BM145891 BX281671 BQ068277 CA433534 NM_000419 AF098114 R28994 
    BX116497 BC030200 AW204899 BI821446 BE018845 BF513348 BM920426 M18085 
    AL048974 BX438406 AI199038 BX331871 BI756161 CB854857 BX442835 BI918426 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -           -                                                     -                                                                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                -                                                                                                                           
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                          -                           
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ITGA2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA2B expression in normal human tissues (normalized intensities)      ITGA2B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAGGTCG
    ITGA2B Expression
    About this image


    ITGA2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 18 entries
             Megakaryocytes Hematopoietic Bone Marrow
             Hematopoietic progenitor cells ( Generation of hematopoietic progenitor cells, megakaryocytes...
             Fetal Liver CD36+ Cells   
             cord blood   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Liver Lobule
             Fetal Liver CD36+ Cells   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             bone marrow   
     
     Yolk Sac (Extraembryonic Tissues)    fully expand to see all 2 entries
             Erythroid Progenitor Cells Definitive Yolk Sac
     
     Thymus (Hematopoietic System)
             Hematopoietic Stem Cells Thymus

    See ITGA2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA2B

    SOURCE GeneReport for Unigene cluster: Hs.411312

    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
    Tissue specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in
    reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate
    adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells

        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA2B: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA2B gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga2b1 , 5 integrin alpha 2b1, 5 82.51(n)1
    80.95(a)1
      11 (66.29 cM)5
    163991  NM_010575.21  NP_034705.21 
     1024532975 
    chicken
    (Gallus gallus)
    Aves --
    --
    18(a)
    possible ortholog
    14(15101013-15111601)
    lizard
    (Anolis carolinensis)
    Reptilia ITGA2B6
    integrin, alpha 2b (platelet glycoprotein IIb of I...
    48(a)
    1 ↔ 1
    6(64000512-64058099)
    zebrafish
    (Danio rerio)
    Actinopterygii itga2b1 integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa more 52.8(n)
    44.85(a)
      445380  NM_001003857.1  NP_001003857.1 


    ENSEMBL Gene Tree for ITGA2B (if available)
    TreeFam Gene Tree for ITGA2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA2B gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  
    7 SIMAP similar genes for ITGA2B using alignment to 8 protein entries:     ITA2B_HUMAN (see all proteins):
    ITGA3    ITGA7    ITGA8    ITGA4    ITGA5    ITGAV
    ITGA9

    ITGA2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
    Polymorphism: Position 874 is associated with platelet-specific alloantigen HPA-3/BAK/LEK. HPA-3A/BAK(A)/LEK(A)
    has Ile-874 and HPA-3B/BAK(B)/LEK(B) has Ser-874. HPA-3B is involved in neonatal alloimmune thrombocytopenia
    (NAIT or NATP)


    10/592 SNPs in ITGA2B are shown (see all 592)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0304514
    Glanzmann thrombasthenia (GT)4--see VAR_0304512 L P mis40--------
    VAR_0304664
    Glanzmann thrombasthenia (GT)4--see VAR_0304662 V M mis40--------
    VAR_0039824
    Glanzmann thrombasthenia (GT)4--see VAR_0039822 Q P mis40--------
    VAR_0304604
    Glanzmann thrombasthenia (GT)4--see VAR_0304602 I T mis40--------
    VAR_0304624
    Glanzmann thrombasthenia (GT)4--see VAR_0304622 L V mis40--------
    VAR_0304484
    Glanzmann thrombasthenia (GT)4--see VAR_0304482 Y H mis40--------
    VAR_0304574
    Glanzmann thrombasthenia (GT)4--see VAR_0304572 G R mis40--------
    VAR_0304564
    Glanzmann thrombasthenia (GT)4--see VAR_0304562 I T mis40--------
    VAR_0304454
    Glanzmann thrombasthenia (GT)4--see VAR_0304452 L P mis40--------
    VAR_0098864
    Glanzmann thrombasthenia (GT)4--see VAR_0098862 P L mis40--------

    HapMap Linkage Disequilibrium report for ITGA2B (42449548 - 42466873 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ITGA2B:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3175n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): ITGA2B

    Locus Specific Mutation Databases (LSDB): ITGA2B
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607759   
    OMIM disorders: 273800  
    UniProtKB/Swiss-Prot: ITA2B_HUMAN, P08514
  • Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is
    characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into
    types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and
    lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at
    reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 20/58 diseases for ITGA2B (see all 58):    About MalaCards
    thrombasthenia    glanzmann's thrombasthenia    basilar artery occlusion    thrombasthenia of glanzmann and naegeli, itga2b-related
    hemorrhagic fever with renal syndrome    bernard-soulier syndrome    gas gangrene    intermediate coronary syndrome
    megakaryocytic leukemia    autoimmune thrombocytopenic purpura    purpura    macrothrombocytopenia
    blood clots    takayasu's arteritis    heparin-induced thrombocytopenia    von willebrand's disease
    myelitis    thrombocytopenia    retinal vein occlusion    sickle cell anemia

    12 diseases from the University of Copenhagen DISEASES database for ITGA2B:
    Glanzmann's thrombasthenia     Myocardial infarction     Intermediate coronary syndrome     Thrombocytopenia
    Coronary heart disease     Bernard-Soulier syndrome     Cerebrovascular accident     Autoimmune thrombocytopenic purpura
    Atherosclerosis     Von Willebrand's disease     Leukemia     Diabetes mellitus

    ITGA2B for disorders           About GeneDecksing

    10/21 Novoseek inferred disease relationships for ITGA2B gene (see all 21)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glanzmann thrombasthenia 94.6 31 1967954 (3), 20020534 (2), 1635160 (1), 7794942 (1) (see all 26)
    bernard-soulier syndrome 73.7 1 8457642 (1)
    posttransfusion purpura 64.1 1 15678278 (1)
    platelet disorder 60.9 1 16793673 (1)
    coagulopathy 58.1 3 1967954 (1), 20020534 (1), 9695977 (1)
    thrombocytopenia 53 4 12724616 (1), 15678278 (1), 15157339 (1), 2301979 (1)
    erythroleukemia 49.6 2 2351656 (1), 10575637 (1)
    autoimmune thrombocytopenia 40 1 15678278 (1)
    purpura thrombocytopenic 39.7 1 7605170 (1)
    leukemia 27.1 2 8750618 (1), 7539513 (1)

    Genatlas disease: ITGA2B
    Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)

    Genetic Association Database (GAD): ITGA2B
    Human Genome Epidemiology (HuGE) Navigator: ITGA2B (65 documents)

    Export disorders for ITGA2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA2B gene, integrated from 9 sources (see all 535):
    (articles sorted by number of sources associating them with ITGA2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Double heterozygosity of the GPIIb gene in a Swiss patient with Glanzmann's thrombasthenia. (PubMed id 9734640)1, 2, 9 Ruan J.... Nurden A.T. (1998)
    2. Glanzmann thrombasthenia resulting from a single amino acid substitution between the second and third calcium-binding domains of GPIIb. Role of the GPIIb amino terminus in integrin subunit association. (PubMed id 7706461)1, 2, 9 Wilcox D.A.... Newman P.J. (1995)
    3. Glanzmann thrombasthenia secondary to a Gly273-->Asp mutation adjacent to the first calcium-binding domain of platelet glycoprotein IIb. (PubMed id 8282784)1, 2, 9 Poncz M.... Bennett J.S. (1994)
    4. GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. (PubMed id 2345548)1, 2, 9 Frachet P....Marguerie G. (1990)
    5. Molecular genetic analysis of a compound heterozygote for the glycoprotein (GP) IIb gene associated with Glanzmann's thrombasthenia: disruption of the 674-687 disulfide bridge in GPIIb prevents surface exposure of GPIIb-IIIa complexes. (PubMed id 9920835)1, 2, 9 Gonzalez-Manchon C.... Parrilla R. (1999)
    6. Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs. (PubMed id 2351656)1, 2, 9 Bray P.F.... Shuman M.A. (1990)
    7. Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen system. (PubMed id 2350579)1, 2, 9 Lyman S.... Newman P.J. (1990)
    8. Organization of the gene for platelet glycoprotein IIb. (PubMed id 2322558)1, 2, 9 Heidenreich R.... Poncz M. (1990)
    9. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PubMed id 15227729)1, 4, 9 Park S....Jang Y. (2004)
    10. Human platelet alloantigens HPA-1, HPA-2, and HPA-3 p olymorphisms associated with extent of severe coronary artery disease. (PubMed id 19562259)1, 4, 9 Abboud N....Mahjoub T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3674 HGNC: 6138 AceView: ITGA2B Ensembl:ENSG00000005961 euGenes: HUgn3674
    ECgene: ITGA2B Kegg: 3674 H-InvDB: ITGA2B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA2B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA2B Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGA2B

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA2B gene:
    Search GeneIP for patents involving ITGA2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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