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Aliases for ITGA2B Gene

Aliases for ITGA2B Gene

  • Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41) 2 3
  • GP2B 3 4 6
  • Platelet Membrane Glycoprotein IIb 3 4
  • GPalpha IIb 3 4
  • BDPLT16 3 6
  • BDPLT2 3 6
  • CD41B 3 6
  • GPIIb 3 4
  • GT 3 6
  • Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41B) 2
  • Protein Phosphatase 1, Regulatory Subunit 93 3
  • Platelet Fibrinogen Receptor, Alpha Subunit 3
  • Platelet-Specific Antigen BAK 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 93 2
  • Integrin Alpha-IIb 3
  • CD41 Antigen 4
  • PPP1R93 3
  • ITGAB 4
  • CD41 3
  • HPA3 3
  • GTA 3

External Ids for ITGA2B Gene

Previous HGNC Symbols for ITGA2B Gene

  • GP2B

Previous GeneCards Identifiers for ITGA2B Gene

  • GC17M042191
  • GC17M044626
  • GC17M042460
  • GC17M042924
  • GC17M039805
  • GC17M038213

Summaries for ITGA2B Gene

Entrez Gene Summary for ITGA2B Gene

  • ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA2B Gene

ITGA2B (Integrin, Alpha 2b (Platelet Glycoprotein IIb Of IIb/IIIa Complex, Antigen CD41)) is a Protein Coding gene. Diseases associated with ITGA2B include glanzmann thrombasthenia and bleeding disorder, platelet-type, 16, autosomal dominant. Among its related pathways are PI3K-Akt signaling pathway and Ras signaling pathway. GO annotations related to this gene include identical protein binding and extracellular matrix binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA2B Gene

  • Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface

Tocris Summary for ITGA2B Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA2B Gene

Genomics for ITGA2B Gene

Regulatory Elements for ITGA2B Gene

Transcription factor binding sites by QIAGEN in the ITGA2B gene promoter:

Genomic Location for ITGA2B Gene

Start:
44,372,180 bp from pter
End:
44,389,505 bp from pter
Size:
17,326 bases
Orientation:
Minus strand

Genomic View for ITGA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA2B Gene

Proteins for ITGA2B Gene

  • Protein details for ITGA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08514-ITA2B_HUMAN
    Recommended name:
    Integrin alpha-IIb
    Protein Accession:
    P08514
    Secondary Accessions:
    • B2RCY8
    • O95366
    • Q14443
    • Q17R67

    Protein attributes for ITGA2B Gene

    Size:
    1039 amino acids
    Molecular mass:
    113377 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for ITGA2B Gene

    Alternative splice isoforms for ITGA2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA2B Gene

Proteomics data for ITGA2B Gene at MOPED

Post-translational modifications for ITGA2B Gene

  • Glycosylation at Asn46, Asn280, Asn601, Asn711, Ile874, Ser878, and Asn962
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGA2B (Integrin alpha 2b/CD41)
  • Cell Signaling Technology (CST) Antibodies for ITGA2B (ITGA2b)

No data available for DME Specific Peptides for ITGA2B Gene

Domains for ITGA2B Gene

Gene Families for ITGA2B Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Graphical View of Domain Structure for InterPro Entry

P08514

UniProtKB/Swiss-Prot:

ITA2B_HUMAN :
  • P08514
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA2B: view

Function for ITGA2B Gene

Molecular function for ITGA2B Gene

GENATLAS Biochemistry: integrin,alpha 2B,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB3 in fibrinogen,fibronectin,von Willebrand factor,vitronectin,thrombospondin receptors
UniProtKB/Swiss-Prot Function: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface

Gene Ontology (GO) - Molecular Function for ITGA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14681217
GO:0042802 identical protein binding IPI 11606749
GO:0046872 metal ion binding IEA --
GO:0050840 extracellular matrix binding IEA --
GO:0070051 fibrinogen binding IEA --
genes like me logo Genes that share ontologies with ITGA2B: view
genes like me logo Genes that share phenotypes with ITGA2B: view

Animal Models for ITGA2B Gene

MGI Knock Outs for ITGA2B:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA2B

Clone Products

  • R&D Systems cDNA Clones for ITGA2B (Integrin alpha 2b/CD41)

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ITGA2B Gene

Localization for ITGA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA2B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA2B Gene COMPARTMENTS Subcellular localization image for ITGA2B gene
Compartment Confidence
extracellular 4
plasma membrane 4
cytoskeleton 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITGA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2439501
GO:0005925 focal adhesion IEA --
GO:0008305 integrin complex IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ITGA2B: view

Pathways for ITGA2B Gene

genes like me logo Genes that share pathways with ITGA2B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ITGA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0007155 cell adhesion TAS 10429193
GO:0007160 cell-matrix adhesion IEA --
GO:0007229 integrin-mediated signaling pathway IDA 23382103
genes like me logo Genes that share ontologies with ITGA2B: view

Compounds for ITGA2B Gene

(5) Tocris Compounds for ITGA2B Gene

Compound Action Cas Number
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0]
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 [327613-57-0]
Eptifibatide Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation [188627-80-7]
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5]

(2) Drugbank Compounds for ITGA2B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Abciximab
  • 7E3
143653-53-6 target antagonist
Tirofiban
144494-65-5 target antagonist

(13) Novoseek inferred chemical compound relationships for ITGA2B Gene

Compound -log(P) Hits PubMed IDs
fibrinogen 74.9 38
adp 59.8 4
12-o-tetradecanoylphorbol 13-acetate 30.3 3
gf 109203x 20.7 1
abciximab 20 2
genes like me logo Genes that share compounds with ITGA2B: view

Transcripts for ITGA2B Gene

Unigene Clusters for ITGA2B Gene

Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA2B

Clone Products

  • R&D Systems cDNA Clones for ITGA2B (Integrin alpha 2b/CD41)

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ITGA2B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - -
SP2:
SP3:
SP4: -
SP5:

ExUns: 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30
SP1: -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for ITGA2B Gene

GeneLoc Exon Structure for
ITGA2B
ECgene alternative splicing isoforms for
ITGA2B

Expression for ITGA2B Gene

mRNA expression in normal human tissues for ITGA2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA2B Gene

This gene is overexpressed in Whole Blood (28.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGA2B Gene

SOURCE GeneReport for Unigene cluster for ITGA2B Gene Hs.411312

mRNA Expression by UniProt/SwissProt for ITGA2B Gene

P08514-ITA2B_HUMAN
Tissue specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells
genes like me logo Genes that share expressions with ITGA2B: view

In Situ Assay Products

Orthologs for ITGA2B Gene

This gene was present in the common ancestor of animals.

Orthologs for ITGA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA2B 35
  • 99.49 (n)
  • 99.42 (a)
ITGA2B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA2B 35
  • 84.72 (n)
  • 80.04 (a)
ITGA2B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA2B 35
  • 86.08 (n)
  • 83.4 (a)
ITGA2B 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga2b 35
  • 82.47 (n)
  • 81.05 (a)
Itga2b 16
Itga2b 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA2B 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Itga2b 35
  • 81.8 (n)
  • 78.65 (a)
chicken
(Gallus gallus)
Aves ITGA2B 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA2B 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga2b.1 35
  • 53.18 (n)
  • 47.46 (a)
zebrafish
(Danio rerio)
Actinopterygii itga2b 35
  • 52.5 (n)
  • 44.22 (a)
itga2b 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta if 36
  • 20 (a)
OneToMany
scb 37
  • 25 (a)
alphaPS5 37
  • 26 (a)
alphaPS4 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea pat-2 36
  • 24 (a)
OneToMany
Species with no ortholog for ITGA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITGA2B Gene

ENSEMBL:
Gene Tree for ITGA2B (if available)
TreeFam:
Gene Tree for ITGA2B (if available)

Paralogs for ITGA2B Gene

Selected SIMAP similar genes for ITGA2B Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ITGA2B: view

Variants for ITGA2B Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA2B Gene

P08514-ITA2B_HUMAN
Position 874 is associated with platelet-specific alloantigen HPA-3/BAK/LEK. HPA-3A/BAK(A)/LEK(A) has Ile-874 and HPA-3B/BAK(B)/LEK(B) has Ser-874. HPA-3B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP)

Sequence variations from dbSNP and Humsavar for ITGA2B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs5910 -- 44,372,421(-) CAGGT(C/T)GGCTT reference, synonymous-codon
rs5911 Pathogenic, - 44,375,697(+) TGGGG(A/C)TGGGC missense, reference
rs5912 -- 44,379,752(-) CTACC(A/G)CCCAC synonymous-codon, reference
rs5913 -- 44,374,686(-) CCCCC(A/G)CTCAG synonymous-codon, reference
rs5914 - 44,374,700(-) TCCCC(A/T)ATGCG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ITGA2B Gene

Variant ID Type Subtype PubMed ID
dgv3175n71 CNV Loss 21882294

Relevant External Links for ITGA2B Gene

HapMap Linkage Disequilibrium report
ITGA2B
Human Gene Mutation Database (HGMD)
ITGA2B
Locus Specific Mutation Databases (LSDB)
ITGA2B

Disorders for ITGA2B Gene

(2) OMIM Diseases for ITGA2B Gene (607759)

UniProtKB/Swiss-Prot

ITA2B_HUMAN
  • Glanzmann thrombasthenia (GT) [MIM:273800]: A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. {ECO:0000269 PubMed:10607701, ECO:0000269 PubMed:11798398, ECO:0000269 PubMed:12083483, ECO:0000269 PubMed:12181054, ECO:0000269 PubMed:12424194, ECO:0000269 PubMed:12506038, ECO:0000269 PubMed:15099289, ECO:0000269 PubMed:15219201, ECO:0000269 PubMed:17018384, ECO:0000269 PubMed:20020534, ECO:0000269 PubMed:7508443, ECO:0000269 PubMed:7706461, ECO:0000269 PubMed:8282784, ECO:0000269 PubMed:8704171, ECO:0000269 PubMed:9215749, ECO:0000269 PubMed:9473221, ECO:0000269 PubMed:9722314, ECO:0000269 PubMed:9734640, ECO:0000269 PubMed:9763559, ECO:0000269 PubMed:9920835}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Bleeding disorder, platelet-type 16 (BDPLT16) [MIM:187800]: An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. {ECO:0000269 PubMed:21454453, ECO:0000269 PubMed:9834222}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(21) Novoseek inferred disease relationships for ITGA2B Gene

Disease -log(P) Hits PubMed IDs
glanzmann thrombasthenia 94.6 29
bernard-soulier syndrome 73.7 1
posttransfusion purpura 64.1 1
platelet disorder 60.9 1
coagulopathy 58.1 3

Genatlas disease for ITGA2B Gene

Glanzmann thrombasthenia (GpIIb-GpIIIa complex deficiency)

Relevant External Links for ITGA2B

Genetic Association Database (GAD)
ITGA2B
Human Genome Epidemiology (HuGE) Navigator
ITGA2B
genes like me logo Genes that share disorders with ITGA2B: view

Publications for ITGA2B Gene

  1. GPIIb and GPIIIa amino acid sequences deduced from human megakaryocyte cDNAs. (PMID: 2345548) Frachet P. … Marguerie G. (Mol. Biol. Rep. 1990) 3 4 23
  2. Polymorphism of human platelet membrane glycoprotein IIb associated with the Baka/Bakb alloantigen system. (PMID: 2350579) Lyman S. … Newman P.J. (Blood 1990) 3 4 23
  3. Human platelets and megakaryocytes contain alternately spliced glycoprotein IIb mRNAs. (PMID: 2351656) Bray P.F. … Shuman M.A. (J. Biol. Chem. 1990) 3 4 23
  4. Organization of the gene for platelet glycoprotein IIb. (PMID: 2322558) Heidenreich R. … Poncz M. (Biochemistry 1990) 3 4 23
  5. A single amino acid substitution flanking the fourth calcium binding domain of alpha IIb prevents maturation of the alpha IIb beta 3 integrin complex. (PMID: 7508443) Wilcox D.A. … Newman P.J. (J. Biol. Chem. 1994) 3 4 23

Products for ITGA2B Gene

  • antibodies-online peptides for ITGA2B
  • antibodies-online antibodies for ITGA2B
  • antibodies-online kits for ITGA2B

Sources for ITGA2B Gene

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