Aliases for ITGA2 Gene
- Integrin Subunit Alpha 2 2 3 5
- Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor) 2 3
- Alpha 2 Subunit Of VLA-2 Receptor 2 3
- Platelet Membrane Glycoprotein Ia 3 4
- CD49 Antigen-Like Family Member B 3 4
- Collagen Receptor 3 4
- CD49B 3 4
- GPIa 3 4
- Very Late Activation Protein 2 Receptor, Alpha-2 Subunit 3
- Human Platelet Alloantigen System 5 3
External Ids for ITGA2 Gene
Previous HGNC Symbols for ITGA2 Gene
Previous GeneCards Identifiers for ITGA2 Gene
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for ITGA2 Gene
ITGA2 (Integrin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with ITGA2 include Glycoprotein Ia Deficiency and Thrombocytopenia. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include protein heterodimerization activity and integrin binding. An important paralog of this gene is ITGA1.
UniProtKB/Swiss-Prot for ITGA2 Gene
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).