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ITGA2 Gene

protein-coding   GIFtS: 68
GCID: GC05P052321

Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)


(Previous symbol: CD49B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)1 2     Human Platelet Alloantigen System 52
CD49B1 2 3 5     Integrin Alpha-22
Collagen Receptor2 3     Platelet Antigen Br2
Platelet Membrane Glycoprotein Ia2 3     Platelet Glycoprotein GPIa2
GPIa2 3     Very Late Activation Protein 2 Receptor, Alpha-2 Subunit2
CD49 Antigen-Like Family Member B2 3     VLA2 Receptor, Alpha-2 Subunit2
BR2 5     CD49b Antigen3
HPA-52     VLA-2 Subunit Alpha3
VLA-22     BDPLT95
VLAA22     

External Ids:    HGNC: 61371   Entrez Gene: 36732   Ensembl: ENSG000001641717   OMIM: 1929745   UniProtKB: P173013   

Export aliases for ITGA2 gene to outside databases

Previous GC identifers: GC05P052449 GC05P053715 GC05P052255 GC05P052301 GC05P049257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA2 Gene:
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded
protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to
the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9.
Antibodies against this protein are found in several immune disorders, including neonatal alloimmune
thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for ITGA2 Gene:
ITGA2 (integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)) is a protein-coding gene. Diseases associated with ITGA2 include glycoprotein 1a deficiency, and anus disease. GO annotations related to this gene include virus receptor activity and collagen binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301
Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and
E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for
adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force
generation and organization of newly synthesized extracellular matrix

Gene Wiki entry for ITGA2 (CD49b) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA2 gene promoter:
         Sox5   FOXF2   POU2F1   POU2F1a   Nkx2-5   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA2 promoter sequence
   Search Chromatin IP Primers for ITGA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

ITGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052321:  view genomic region     (about GC identifiers)

Start:
52,285,156 bp from pter      End:
52,390,609 bp from pter
Size:
105,454 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301 (See protein sequence)
Recommended Name: Integrin alpha-2 precursor  
Size: 1181 amino acids; 129295 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and
RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts
(via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains,
for which ITGA2 acts as a receptor
5 PDB 3D structures from and Proteopedia for ITGA2:
1AOX (3D)        1DZI (3D)        1PQB (3D)        1V7P (3D)        4BJ3 (3D)    
Secondary accessions: Q14595

Explore the universe of human proteins at neXtProt for ITGA2: NX_P17301

Explore proteomics data for ITGA2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn105, Asn112, Asn343, Asn432, Asn460, Asn475, Asn699, Asn1057, Asn1074, Asn1081
  • Modification sites at PhosphoSitePlus

  • See ITGA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002194.2  
    ENSEMBL proteins: 
     ENSP00000296585   ENSP00000426489   ENSP00000422095   ENSP00000424397   ENSP00000424642  
     ENSP00000422145  
    Reactome Protein details: P17301

    ITGA2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA2 (Integrin alpha 2 beta 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ITGA2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ITGA2
    GenScript Custom Purified and Recombinant Proteins Services for ITGA2
    Novus Biologicals ITGA2 Protein
    Novus Biologicals ITGA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ITGA2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA2
    R&D Systems Antibodies for ITGA2 (Integrin alpha 2/CD49b)
    OriGene Antibodies for ITGA2
    OriGene Custom Antibody Services for ITGA2
    Novus Biologicals ITGA2 Antibodies
    Abcam antibodies for ITGA2 (P05556, P17301)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for ITGA2
    LSBio Antibodies in human, mouse, rat for ITGA2

    ITGA2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ITGA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    Selected InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P17301

    ProtoNet protein and cluster: P17301

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA2_HUMAN, P17301
    Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and
    E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for
    adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force
    generation and organization of newly synthesized extracellular matrix

         Genatlas biochemistry entry for ITGA2:
    integrin,alpha 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,component of VLA-2 receptor,dimerizing with ITGB1 in collagen,laminin receptors

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI14681217
    GO:0005518collagen binding TAS9391074
    GO:0032403protein complex binding ----
         
    ITGA2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itga2):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  integument 
     normal 

    ITGA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGA2: Itga2tm1Ztr Itga2tm1.1Eck

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA2:
    hsa-mir-103a-3p (MIRT027119), hsa-mir-30a-5p (MIRT005123), hsa-mir-16-5p (MIRT001449), hsa-mir-335-5p (MIRT017602)

    Block miRNA regulation of human, mouse, rat ITGA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA2 (see all 33):
    hsa-miR-2052 hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA2
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA2

    Clone
    Products:
         
    OriGene clones in human, mouse for ITGA2 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA2 (NM_002203)
    Sino Biological Human cDNA Clone for ITGA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ITGA2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ITGA2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA2_HUMAN, P17301: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular3
    cytoskeleton2
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0005925focal adhesion IEA--
    GO:0008305integrin complex IEA--
    GO:0009279cell outer membrane IEA--

    ITGA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA2 About   (see all 41)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    CHL1 interactions0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGA2
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA2 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    5 GeneGo (Thomson Reuters) Pathways for ITGA2
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cytoskeleton remodeling FAK signaling

    Selected BioSystems Pathways for ITGA2 (see all 8)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Interleukin-11 Signaling Pathway
    Arrhythmogenic right ventricular cardiomyopathy
    Arf6 trafficking events


    Selected Reactome Pathways for ITGA2 (see all 6)
        Platelet Adhesion to exposed collagen
    ECM proteoglycans
    Laminin interactions
    Integrin cell surface interactions
    CHL1 interactions

    1 PharmGKB Pathway for ITGA2
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ITGA2) (see all 12):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage


    ITGA2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA2 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Atherosclerosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA2 (P173011, 2, 3 ENSP000002965854) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIB1Q998282, 3, ENSP000003338734MINT-1894979 I2D: score=1 STRING: ENSP00000333873
    PDIA3P301012, 3MINT-4301430 I2D: score=1 
    ITGB1P055561, 3, ENSP000003640944EBI-702960,EBI-703066 I2D: score=3 STRING: ENSP00000364094
    COL1A2P081232, 3, ENSP000002972684MINT-4792053 I2D: score=2 STRING: ENSP00000297268
    WASLO004012, 3, ENSP000002230234MINT-1895068 I2D: score=1 STRING: ENSP00000223023
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 43):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0001894tissue homeostasis IEA--
    GO:0002687positive regulation of leukocyte migration IEA--
    GO:0006928cellular component movement ----
    GO:0006971hypotonic response IEA--

    ITGA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGA2 (ITA2)

    Selected Novoseek inferred chemical compound relationships for ITGA2 gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bacteriorhodopsin 96.8 1488 15842995 (8), 16039842 (7), 8874028 (7), 12058039 (7) (see all 99)
    bacterioopsin 83.5 31 8652531 (3), 2344462 (2), 8580348 (2), 2350173 (1) (see all 8)
    convulxin 63.6 2 12881531 (1)
    hydrogen 58.3 147 15842995 (6), 8349659 (4), 10694399 (4), 15298873 (3) (see all 64)
    tyrosinate 54 6 1653012 (2), 2167129 (1), 2060632 (1)
    beta-ionone 52.2 1 8652531 (1)
    grgdsp 47.7 2 1331077 (1), 7843907 (1)
    matrigel 44.6 2 18554474 (1), 8985098 (1)
    adp 44.2 14 15850609 (1), 14734152 (1), 18253477 (1), 16381175 (1) (see all 10)
    fibrinogen 41.7 9 7503943 (1), 10168553 (1), 10554707 (1), 15665914 (1) (see all 9)

    2 PharmGKB related drug/compound annotations for ITGA2 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  
    clopidogrelCA  



    ITGA2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITGA2 gene: 
    NM_002203.3  

    Unigene Cluster for ITGA2:

    Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
    Hs.482077  [show with all ESTs]
    Unigene Representative Sequence: NR_073105
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296585(uc003joy.3 uc011cqa.2 uc011cqb.2 uc011cqc.2 uc011cqd.2 uc011cqe.2)
    ENST00000503810 ENST00000513685 ENST00000509814 ENST00000509960 ENST00000510722

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ITGA2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA2 (see all 33):
    hsa-miR-2052 hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITGA2
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA2
    Clone
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    OriGene clones in human, mouse for ITGA2 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA2 (NM_002203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA2
      QuantiTect SYBR Green Assays in human, mouse, rat ITGA2
      QuantiFast Probe-based Assays in human, mouse, rat ITGA2

    Additional mRNA sequence: 

    AK307952.1 BC143505.1 BC143508.1 BC143509.1 BC143511.1 BC143512.1 NR_073103.1 NR_073104.1 
    NR_073105.1 NR_073106.1 NR_073107.1 X17033.1 

    7 DOTS entries:

    DT.113328  DT.97818767  DT.40296409  DT.91687975  DT.40126600  DT.97806649  DT.91827777 

    Selected AceView cDNA sequences (see all 135):

    BM987549 AA366887 BQ001409 AA991803 BU676023 BG771368 AA236162 AA307466 
    BM826223 BM798135 CA419950 BQ101227 AI309192 BM979113 AA993294 CA442768 
    BU782863 CB241295 CK823194 AI339858 CA444519 AI538195 AI355720 CK904145 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                          -     -                                                                                                                           

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for ITGA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA2 expression in normal human tissues (normalized intensities)      ITGA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTACAAA
    ITGA2 Expression
    About this image


    ITGA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
             Human multipotent adipose-derived (hMAD) stem cells
             Mesenchymal stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived adherent progenitor cells (MultiStem)
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
             Limbal epithelial stem cells (family)
     
     Cartilage (Muscoskeletal System)
             Bone Marrow Stromal Cells Bone Marrow
     
     Epithelial Cells
             Adult Corneal Superbasal Epithelial Cells Corneal Epithelium
    ITGA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482077
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA2 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Atherosclerosis in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga21 , 5 integrin alpha 21, 5 83.08(n)1
    82.51(a)1
      13 (64.61 cM)5
    163981  NM_008396.21  NP_032422.21 
     1148359165 
    chicken
    (Gallus gallus)
    Aves ITGA21 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more 70.59(n)
    67.45(a)
      100857227  XM_003642982.2  XP_003643030.2 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA26
    integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2...
    65(a)
    1 ↔ 1
    2(3554627-3627202)
    African clawed frog
    (Xenopus laevis)
    Amphibia itga2-A2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more 74.77(n)    L43058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itga2.21 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more 57.17(n)
    51.61(a)
      100536533  XM_003199304.2  XP_003199352.2 


    ENSEMBL Gene Tree for ITGA2 (if available)
    TreeFam Gene Tree for ITGA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA2 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    12 SIMAP similar genes for ITGA2 using alignment to 13 protein entries:     ITA2_HUMAN (see all proteins):
    ITGA1    VIT    ITGA11    ITGA10    ITGAX    COL21A1
    COL6A6    COL14A1    MATN2    COL12A1    COL22A1    COL6A3

    ITGA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ITA2_HUMAN, P17301: Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534
    and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The
    Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD)


    Selected SNPs for ITGA2 (see all 2320)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998084991,2
    Cuntested152295449(+) TTACTA/CTCAAA 7 I L nc-transcript-variantmis11Minor allele frequency- C:0.00EU 1317
    rs1995568161,2
    --49257722(+) CACAC-/AGACAGA 6 -- int10--------
    rs401181,2
    C,H--49257723(+) ACACAC/GACAGA 6 -- int12Minor allele frequency- G:0.00NA 4
    rs2012088221,2
    --49259886(+) TTCCA-/CCCCAG 6 -- int10--------
    rs19462681,2
    C,H--49290096(-) cccccA/Caaaaa 6 -- int10--------
    rs1389755651,2
    C--49290096(+) ttttt-/G/Tggggg 6 -- int11NA 2
    rs718172141,2
    C--49303922(+) TCGTA-/ATTC  
            
    TTCAT
    6 -- int10--------
    rs114214191,2
    C--49312161(+) AAAAAA/-AAAAA 6 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs2014242141,2
    C--49312186(-) CCTTTC/TTTTTT 6 -- int10--------
    rs1432924261,2
    C--49352171(+) TTTTT-/TCTTTT 6 -- int10--------

    HapMap Linkage Disequilibrium report for ITGA2 (52285156 - 52390609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGA2 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6057n71CNV Loss21882294
    dgv6052n71CNV Loss21882294
    dgv6053n71CNV Loss21882294
    nsv881652CNV Loss21882294
    dgv6055n71CNV Loss21882294
    nsv880425CNV Loss21882294
    nsv881217CNV Loss21882294
    dgv6061n71CNV Loss21882294
    dgv6059n71CNV Loss21882294
    dgv6056n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): ITGA2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA2
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192974   
    OMIM disorders: 614200  
    Selected diseases for ITGA2 (see all 111):    About MalaCards
    glycoprotein 1a deficiency    anus disease    thrombocytopenia    fetal and neonatal alloimmune thrombocytopenia
    glanzmann's thrombasthenia    thrombasthenia    gingival overgrowth    osteomyelitis
    septic arthritis    bernard-soulier syndrome    autoimmune thrombocytopenic purpura    retinal vein occlusion
    heparin-induced thrombocytopenia    alport syndrome    gingivitis    thromboembolism
    von willebrand's disease    progressive myoclonus epilepsy    brucellosis    oral cancer

    6 diseases from the University of Copenhagen DISEASES database for ITGA2:
    Brucellosis     Progressive myoclonus epilepsy     Cancer     Thrombocytopenia
    Anus disease     Appendicitis

    ITGA2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ITGA2 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arterial thrombosis 43.7 2 20076847 (1), 9701455 (1)
    collagen fibril 38.9 1 16854461 (1)
    glanzmann thrombasthenia 35.5 1 10097812 (1)
    metastasis 32.1 23 19738067 (4), 7681030 (2), 2011740 (1), 9306710 (1) (see all 13)
    thrombosis 26.5 3 17164499 (1), 18045662 (1), 12617110 (1)
    bernard-soulier syndrome 26.4 1 10097812 (1)
    osteosarcoma 25 3 8326445 (1), 9716443 (1)
    rhabdomyosarcoma 21.5 6 2011740 (2), 9306710 (1), 8674074 (1), 7630001 (1)
    colon carcinoma 18.9 4 18098323 (1), 11169447 (1), 2304917 (1)
    colon cancer 17.1 4 12657625 (2), 15304500 (1), 18664572 (1)

    Genatlas disease: ITGA2
    neonatal alloimmune thrombocytopenia

    Genetic Association Database (GAD): ITGA2
    Human Genome Epidemiology (HuGE) Navigator: ITGA2 (123 documents)

    Export disorders for ITGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA2 gene, integrated from 10 sources (see all 805):
    (articles sorted by number of sources associating them with ITGA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. (PubMed id 16317580)1, 4, 9 Langsenlehner U....Krippl P. (Breast Cancer Res. Treat. 2006)
    2. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PubMed id 15227729)1, 4, 9 Park S....Jang Y. (Yonsei Med. J. 2004)
    3. [Association of the integrin gene polymorphisms with ischemic stroke and plasma lipid levels]. (PubMed id 19350519)1, 4, 9 Wei Y.S....Xie H.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    4. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction. (PubMed id 16697311)1, 4, 9 Antoniades C....Stefanadis C. (J. Am. Coll. Cardiol. 2006)
    5. Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer. (PubMed id 16513317)1, 4, 9 Vairaktaris E....Neukam F.W. (Eur J Surg Oncol 2006)
    6. Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. (PubMed id 15978109)1, 4, 9 Di Paola J....Murray J.C. (J. Thromb. Haemost. 2005)
    7. Polymorphisms in platelet glycoproteins Ia and IIIa are associated with arterial thrombosis and carotid atherosclerosis in type 2 diabetes. (PubMed id 20076847)1, 4, 9 Pellitero S....Reverter J.C. (Thromb. Haemost. 2010)
    8. Genetics of platelet reactivity in normal, healthy individuals. (PubMed id 19740098)1, 4, 9 Kunicki T.J....Nugent D.J. (J. Thromb. Haemost. 2009)
    9. Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment. (PubMed id 17157856)1, 4, 9 Giusti B....Abbate R. (Atherosclerosis 2008)
    10. Association of integrin alpha2 gene variants with ischemic stroke. (PubMed id 17534386)1, 4, 9 Matarin M.... . (J. Cereb. Blood Flow Metab. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3673 HGNC: 6137 AceView: ITGA2 Ensembl:ENSG00000164171 euGenes: HUgn3673
    ECgene: ITGA2 Kegg: 3673 H-InvDB: ITGA2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ITGA2[genesymbol]
    SeattleSNPshttp://pga.gs.washington.edu/data/itga2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGA2 gene:
    Search GeneIP for patents involving ITGA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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