Aliases for ITGA2 Gene
- Integrin Subunit Alpha 2 2 3 5
- Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor) 2 3
- Alpha 2 Subunit Of VLA-2 Receptor 2 3
- Platelet Membrane Glycoprotein Ia 3 4
- CD49 Antigen-Like Family Member B 3 4
- Collagen Receptor 3 4
- CD49B 3 4
- GPIa 3 4
- Very Late Activation Protein 2 Receptor, Alpha-2 Subunit 3
- Human Platelet Alloantigen System 5 3
External Ids for ITGA2 Gene
Previous HGNC Symbols for ITGA2 Gene
Previous GeneCards Identifiers for ITGA2 Gene
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
GeneCards Summary for ITGA2 Gene
ITGA2 (Integrin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with ITGA2 include Glycoprotein Ia Deficiency and Thrombocytopenia. Among its related pathways are CXCR4-mediated signaling events and Arrhythmogenic right ventricular cardiomyopathy (ARVC). GO annotations related to this gene include protein heterodimerization activity and integrin binding. An important paralog of this gene is ITGA1.
UniProtKB/Swiss-Prot for ITGA2 Gene
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).