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Aliases for ITGA2 Gene

Aliases for ITGA2 Gene

  • Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor) 2 3
  • Platelet Membrane Glycoprotein Ia 3 4
  • CD49 Antigen-Like Family Member B 3 4
  • Collagen Receptor 3 4
  • CD49B 3 4
  • GPIa 3 4
  • Very Late Activation Protein 2 Receptor, Alpha-2 Subunit 3
  • Human Platelet Alloantigen System 5 3
  • Alpha-2 Subunit Of VLA-2 Receptor 6
  • VLA2 Receptor, Alpha-2 Subunit 3
  • Platelet Glycoprotein GPIa 3
  • Platelet Antigen Br 3
  • VLA-2 Subunit Alpha 4
  • Integrin Alpha-2 3
  • CD49b Antigen 4
  • HPA-5 3
  • VLA-2 3
  • VLAA2 3
  • BR 3

External Ids for ITGA2 Gene

Previous HGNC Symbols for ITGA2 Gene

  • CD49B

Previous GeneCards Identifiers for ITGA2 Gene

  • GC05P052449
  • GC05P053715
  • GC05P052255
  • GC05P052301
  • GC05P052321
  • GC05P049257

Summaries for ITGA2 Gene

Entrez Gene Summary for ITGA2 Gene

  • This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for ITGA2 Gene

ITGA2 (Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)) is a Protein Coding gene. Diseases associated with ITGA2 include glycoprotein ia deficiency and anus disease. Among its related pathways are PI3K-Akt signaling pathway and Proteoglycans in cancer. GO annotations related to this gene include collagen binding and virus receptor activity. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA2 Gene

  • Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix

Gene Wiki entry for ITGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA2 Gene

Genomics for ITGA2 Gene

Regulatory Elements for ITGA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ITGA2 Gene

Start:
52,989,326 bp from pter
End:
53,094,779 bp from pter
Size:
105,454 bases
Orientation:
Plus strand

Genomic View for ITGA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA2 Gene

Proteins for ITGA2 Gene

  • Protein details for ITGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17301-ITA2_HUMAN
    Recommended name:
    Integrin alpha-2
    Protein Accession:
    P17301
    Secondary Accessions:
    • Q14595

    Protein attributes for ITGA2 Gene

    Size:
    1181 amino acids
    Molecular mass:
    129295 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor.

    Three dimensional structures from OCA and Proteopedia for ITGA2 Gene

neXtProt entry for ITGA2 Gene

Proteomics data for ITGA2 Gene at MOPED

Post-translational modifications for ITGA2 Gene

  • Glycosylation at Asn105, Asn112, Asn343, Asn432, Asn460, Asn475, Asn699, Asn1057, Asn1074, and Asn1081
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA2 Gene

Antibody Products

  • R&D Systems Antibodies for ITGA2 (Integrin alpha 2/CD49b)

No data available for DME Specific Peptides for ITGA2 Gene

Domains for ITGA2 Gene

Gene Families for ITGA2 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Graphical View of Domain Structure for InterPro Entry

P17301

UniProtKB/Swiss-Prot:

ITA2_HUMAN :
  • P17301
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA2: view

Function for ITGA2 Gene

Molecular function for ITGA2 Gene

GENATLAS Biochemistry:
integrin,alpha 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,component of VLA-2 receptor,dimerizing with ITGB1 in collagen,laminin receptors
UniProtKB/Swiss-Prot Function:
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix

Gene Ontology (GO) - Molecular Function for ITGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 14681217
GO:0005518 collagen binding IMP 11518510
GO:0032403 protein complex binding --
genes like me logo Genes that share ontologies with ITGA2: view
genes like me logo Genes that share phenotypes with ITGA2: view

Animal Models for ITGA2 Gene

MGI Knock Outs for ITGA2:

miRNA for ITGA2 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA2 Gene

Localization for ITGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA2 Gene COMPARTMENTS Subcellular localization image for ITGA2 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 11518510
GO:0008305 integrin complex TAS 2545729
GO:0009279 cell outer membrane IEA --
genes like me logo Genes that share ontologies with ITGA2: view

Pathways for ITGA2 Gene

genes like me logo Genes that share pathways with ITGA2: view

PCR Array Products

Gene Ontology (GO) - Biological Process for ITGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006928 movement of cell or subcellular component --
GO:0006929 substrate-dependent cell migration IMP 11518510
GO:0006971 hypotonic response IEA --
genes like me logo Genes that share ontologies with ITGA2: view

Compounds for ITGA2 Gene

(68) Novoseek inferred chemical compound relationships for ITGA2 Gene

Compound -log(P) Hits PubMed IDs
bacteriorhodopsin 96.8 420
bacterioopsin 83.5 12
convulxin 63.6 1
hydrogen 58.3 95
tyrosinate 54 4

(2) PharmGKB related drug/compound annotations for ITGA2 Gene

Drug/compound Annotation
aspirin CA
clopidogrel CA
genes like me logo Genes that share compounds with ITGA2: view

Transcripts for ITGA2 Gene

Unigene Clusters for ITGA2 Gene

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITGA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2: - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:

Relevant External Links for ITGA2 Gene

GeneLoc Exon Structure for
ITGA2
ECgene alternative splicing isoforms for
ITGA2

Expression for ITGA2 Gene

mRNA expression in normal human tissues for ITGA2 Gene

mRNA differential expression in normal tissues according to GTEx for ITGA2 Gene

This gene is overexpressed in Minor Salivary Gland (4.4).

Protein differential expression in normal tissues for ITGA2 Gene

This gene is overexpressed in Nasal epithelium (25.0) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA2 Gene

SOURCE GeneReport for Unigene cluster for ITGA2 Gene Hs.482077

genes like me logo Genes that share expressions with ITGA2: view

Expression partners for ITGA2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ITGA2 Gene

Orthologs for ITGA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGA2 35
  • 88.15 (n)
  • 86.51 (a)
ITGA2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA2 35
  • 88.61 (n)
  • 86.94 (a)
ITGA2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga2 35
  • 83.08 (n)
  • 82.51 (a)
Itga2 16
Itga2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGA2 35
  • 99.55 (n)
  • 99.66 (a)
ITGA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga2 35
  • 83.25 (n)
  • 81.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ITGA2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA2 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA2 35
  • 70.59 (n)
  • 67.45 (a)
ITGA2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga2 35
  • 63.5 (n)
  • 60.8 (a)
Str.15525 35
African clawed frog
(Xenopus laevis)
Amphibia itga2-A 35
zebrafish
(Danio rerio)
Actinopterygii itga2.2 35
  • 57.17 (n)
  • 51.61 (a)
ITGA2 (2 of 2) 36
  • 45 (a)
OneToMany
itga2.2 36
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for ITGA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA2 Gene

ENSEMBL:
Gene Tree for ITGA2 (if available)
TreeFam:
Gene Tree for ITGA2 (if available)

Paralogs for ITGA2 Gene

genes like me logo Genes that share paralogs with ITGA2: view

Variants for ITGA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA2 Gene

P17301-ITA2_HUMAN
Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD)

Sequence variations from dbSNP and Humsavar for ITGA2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs26346 -- 53,025,602(+) GAGGC(G/T)CAATG intron-variant
rs26675 -- 53,051,413(+) AAGGT(A/G)GGGTT synonymous-codon, reference, nc-transcript-variant
rs26676 -- 53,045,572(+) CTAAT(C/T)AGTGA intron-variant
rs26677 -- 53,026,628(+) GTAAA(C/G/T)GTTGA intron-variant
rs26678 -- 53,026,891(+) TTTAT(G/T)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA2 Gene

Variant ID Type Subtype PubMed ID
nsv462187 CNV Gain 19166990
nsv471013 CNV Gain 18288195
nsv830296 CNV Gain 17160897
nsv880425 CNV Loss 21882294
nsv881652 CNV Loss 21882294
nsv880389 CNV Loss 21882294
nsv881217 CNV Loss 21882294
dgv6052n71 CNV Loss 21882294
dgv6053n71 CNV Loss 21882294
nsv880531 CNV Loss 21882294
dgv6054n71 CNV Loss 21882294
nsv881388 CNV Gain 21882294
nsv881148 CNV Gain 21882294
nsv881599 CNV Gain 21882294
dgv6055n71 CNV Loss 21882294
dgv6056n71 CNV Loss 21882294
dgv6057n71 CNV Loss 21882294
dgv6058n71 CNV Loss 21882294
dgv6059n71 CNV Loss 21882294
nsv881522 CNV Loss 21882294
nsv880866 CNV Gain 21882294
nsv880427 CNV Loss 21882294
dgv6060n71 CNV Loss 21882294
nsv881684 CNV Gain 21882294
dgv6061n71 CNV Loss 21882294
nsv881446 CNV Gain 21882294
nsv880598 CNV Gain 21882294
nsv880346 CNV Loss 21882294

Relevant External Links for ITGA2 Gene

HapMap Linkage Disequilibrium report
ITGA2
Human Gene Mutation Database (HGMD)
ITGA2

Disorders for ITGA2 Gene

(1) OMIM Diseases for ITGA2 Gene (192974)

(62) Novoseek inferred disease relationships for ITGA2 Gene

Disease -log(P) Hits PubMed IDs
arterial thrombosis 43.7 2
collagen fibril 38.9 1
glanzmann thrombasthenia 35.5 1
metastasis 32.1 17
thrombosis 26.5 3

Genatlas disease for ITGA2 Gene

neonatal alloimmune thrombocytopenia

Relevant External Links for ITGA2

Genetic Association Database (GAD)
ITGA2
Human Genome Epidemiology (HuGE) Navigator
ITGA2
genes like me logo Genes that share disorders with ITGA2: view

No data available for UniProtKB/Swiss-Prot for ITGA2 Gene

Publications for ITGA2 Gene

  1. Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men. (PMID: 11812069) Benze G. … Junker R. (Eur. Heart J. 2002) 3 23 48
  2. Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. (PMID: 12540964) Reiner A.P. … Agardh C.D. (Thromb. Haemost. 2003) 3 23 48
  3. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PMID: 15227729) Park S. … Jang Y. (Yonsei Med. J. 2004) 3 23 48
  4. Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. (PMID: 15978109) Di Paola J. … Murray J.C. (J. Thromb. Haemost. 2005) 3 23 48
  5. Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth. (PMID: 16304451) Ogino M. … Kataoka M. (J. Dent. Res. 2005) 3 23 48

Products for ITGA2 Gene

Sources for ITGA2 Gene

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