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Aliases for ITGA2 Gene

Aliases for ITGA2 Gene

  • Integrin Subunit Alpha 2 2 3 5
  • Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor) 2 3
  • Alpha 2 Subunit Of VLA-2 Receptor 2 3
  • Platelet Membrane Glycoprotein Ia 3 4
  • CD49 Antigen-Like Family Member B 3 4
  • Collagen Receptor 3 4
  • CD49B 3 4
  • GPIa 3 4
  • Very Late Activation Protein 2 Receptor, Alpha-2 Subunit 3
  • Human Platelet Alloantigen System 5 3
  • Platelet Glycoprotein GPIa 3
  • Platelet Antigen Br 3
  • VLA-2 Subunit Alpha 4
  • Integrin Alpha-2 3
  • CD49b Antigen 4
  • HPA-5 3
  • VLA-2 3
  • VLAA2 3
  • BR 3

External Ids for ITGA2 Gene

Previous HGNC Symbols for ITGA2 Gene

  • CD49B

Previous GeneCards Identifiers for ITGA2 Gene

  • GC05P052449
  • GC05P053715
  • GC05P052255
  • GC05P052301
  • GC05P052321
  • GC05P049257

Summaries for ITGA2 Gene

Entrez Gene Summary for ITGA2 Gene

  • This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for ITGA2 Gene

ITGA2 (Integrin Subunit Alpha 2) is a Protein Coding gene. Diseases associated with ITGA2 include Glycoprotein Ia Deficiency and Thrombocytopenia. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include protein heterodimerization activity and integrin binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot for ITGA2 Gene

  • Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

  • (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).

Gene Wiki entry for ITGA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA2 Gene

Genomics for ITGA2 Gene

Regulatory Elements for ITGA2 Gene

Enhancers for ITGA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ITGA2 on UCSC Golden Path with GeneCards custom track

Promoters for ITGA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITGA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGA2 Gene

Chromosome:
5
Start:
52,989,326 bp from pter
End:
53,094,779 bp from pter
Size:
105,454 bases
Orientation:
Plus strand

Genomic View for ITGA2 Gene

Genes around ITGA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA2 Gene

Proteins for ITGA2 Gene

  • Protein details for ITGA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17301-ITA2_HUMAN
    Recommended name:
    Integrin alpha-2
    Protein Accession:
    P17301
    Secondary Accessions:
    • Q14595

    Protein attributes for ITGA2 Gene

    Size:
    1181 amino acids
    Molecular mass:
    129295 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts (via ITAG2 I-domain) with rotavirus A VP4 protein.
    • (Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.

    Three dimensional structures from OCA and Proteopedia for ITGA2 Gene

neXtProt entry for ITGA2 Gene

Post-translational modifications for ITGA2 Gene

  • Glycosylation at Asn 105, Asn 112, Asn 343, Asn 432, Asn 460, Asn 475, Asn 699, Asn 1057, Asn 1074, and Asn 1081
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA2 Gene

No data available for DME Specific Peptides for ITGA2 Gene

Domains & Families for ITGA2 Gene

Gene Families for ITGA2 Gene

Graphical View of Domain Structure for InterPro Entry

P17301

UniProtKB/Swiss-Prot:

ITA2_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA2: view

Function for ITGA2 Gene

Molecular function for ITGA2 Gene

GENATLAS Biochemistry:
integrin,alpha 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,component of VLA-2 receptor,dimerizing with ITGB1 in collagen,laminin receptors
UniProtKB/Swiss-Prot Function:
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).

Gene Ontology (GO) - Molecular Function for ITGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005178 integrin binding IEA --
GO:0005515 protein binding IPI 7639691
GO:0005518 collagen binding IEA,IMP 11518510
GO:0032403 protein complex binding IEA,IPI 25336636
genes like me logo Genes that share ontologies with ITGA2: view
genes like me logo Genes that share phenotypes with ITGA2: view

Human Phenotype Ontology for ITGA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ITGA2 Gene

MGI Knock Outs for ITGA2:

Animal Model Products

CRISPR Products

miRNA for ITGA2 Gene

miRTarBase miRNAs that target ITGA2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGA2
  • R&D Systems cDNA Clones for ITGA2 (Integrin alpha 2/CD49b)

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ITGA2 Gene

Localization for ITGA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA2 Gene COMPARTMENTS Subcellular localization image for ITGA2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
chloroplast 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005886 plasma membrane IEA,TAS --
GO:0005925 focal adhesion IEA,IDA 11518510
GO:0008305 integrin complex TAS 2545729
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ITGA2: view

Pathways & Interactions for ITGA2 Gene

genes like me logo Genes that share pathways with ITGA2: view

SIGNOR curated interactions for ITGA2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ITGA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0002687 positive regulation of leukocyte migration IEA --
GO:0006929 substrate-dependent cell migration IMP 11518510
GO:0006971 hypotonic response IEA --
GO:0007155 cell adhesion TAS 10201960
genes like me logo Genes that share ontologies with ITGA2: view

Drugs & Compounds for ITGA2 Gene

(21) Drugs for ITGA2 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1074
Clopidogrel Approved Nutra P2Y12 receptor antagonist 733

(49) Additional Compounds for ITGA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITGA2: view

Transcripts for ITGA2 Gene

Unigene Clusters for ITGA2 Gene

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITGA2
  • R&D Systems cDNA Clones for ITGA2 (Integrin alpha 2/CD49b)

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1:
SP2: - -

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:

Relevant External Links for ITGA2 Gene

GeneLoc Exon Structure for
ITGA2
ECgene alternative splicing isoforms for
ITGA2

Expression for ITGA2 Gene

mRNA expression in normal human tissues for ITGA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ITGA2 Gene

This gene is overexpressed in Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for ITGA2 Gene

This gene is overexpressed in Nasal epithelium (25.0) and Peripheral blood mononuclear cells (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITGA2 Gene



Protein tissue co-expression partners for ITGA2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITGA2 Gene:

ITGA2

SOURCE GeneReport for Unigene cluster for ITGA2 Gene:

Hs.482077
genes like me logo Genes that share expression patterns with ITGA2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ITGA2 Gene

Orthologs for ITGA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITGA2 34
  • 88.15 (n)
  • 86.51 (a)
ITGA2 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA2 34
  • 88.61 (n)
  • 86.94 (a)
ITGA2 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga2 34
  • 83.08 (n)
  • 82.51 (a)
Itga2 16
Itga2 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITGA2 34
  • 99.55 (n)
  • 99.66 (a)
ITGA2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga2 34
  • 83.25 (n)
  • 81.75 (a)
oppossum
(Monodelphis domestica)
Mammalia ITGA2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA2 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITGA2 34
  • 70.59 (n)
  • 67.45 (a)
ITGA2 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga2 34
  • 63.5 (n)
  • 60.8 (a)
Str.15525 34
African clawed frog
(Xenopus laevis)
Amphibia itga2-A 34
zebrafish
(Danio rerio)
Actinopterygii itga2.2 34
  • 57.17 (n)
  • 51.61 (a)
ITGA2 (2 of 2) 35
  • 45 (a)
OneToMany
itga2.2 35
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for ITGA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA2 Gene

ENSEMBL:
Gene Tree for ITGA2 (if available)
TreeFam:
Gene Tree for ITGA2 (if available)

Paralogs for ITGA2 Gene

genes like me logo Genes that share paralogs with ITGA2: view

Variants for ITGA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA2 Gene

ITA2_HUMAN-P17301
Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).

Sequence variations from dbSNP and Humsavar for ITGA2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1801106 - 53,062,927(+) TCAAA(A/G)AGGTA nc-transcript-variant, reference, missense
rs3212645 - 53,089,976(+) ATGAG(A/C)AAGCC nc-transcript-variant, reference, missense
rs2287870 - 53,075,259(-) TGAGG(A/C/T)TGACC nc-transcript-variant, reference, missense
rs3212557 - 53,067,247(+) CAAAA(A/C)AATCA nc-transcript-variant, reference, missense
rs192190 -- 53,061,251(-) TAGCT(A/T)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA2 Gene

Variant ID Type Subtype PubMed ID
dgv9785n54 CNV loss 21841781
nsv462187 CNV gain 19166990
nsv471013 CNV gain 18288195
nsv473229 CNV novel sequence insertion 20440878
nsv598163 CNV gain 21841781
nsv598166 CNV loss 21841781
nsv598167 CNV loss 21841781
nsv598168 CNV loss 21841781
nsv598169 CNV loss 21841781
nsv598170 CNV loss 21841781
nsv830296 CNV gain 17160897

Variation tolerance for ITGA2 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.78; 79.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA2 Gene

Human Gene Mutation Database (HGMD)
ITGA2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITGA2

Disorders for ITGA2 Gene

MalaCards: The human disease database

(48) MalaCards diseases for ITGA2 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
glycoprotein ia deficiency
  • bleeding disorder, platelet-type, 9
thrombocytopenia
oral hairy leukoplakia
  • hairy leukoplakia
tinea nigra
  • infection by cladosporium werneckii
acute pericementitis
  • acute periodontitis
- elite association - COSMIC cancer census association via MalaCards
Search ITGA2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for ITGA2 Gene

neonatal alloimmune thrombocytopenia

Relevant External Links for ITGA2

Genetic Association Database (GAD)
ITGA2
Human Genome Epidemiology (HuGE) Navigator
ITGA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGA2
genes like me logo Genes that share disorders with ITGA2: view

No data available for UniProtKB/Swiss-Prot for ITGA2 Gene

Publications for ITGA2 Gene

  1. Genetics of platelet reactivity in normal, healthy individuals. (PMID: 19740098) Kunicki T.J. … Nugent D.J. (J. Thromb. Haemost. 2009) 3 22 46 65
  2. [Association of the integrin gene polymorphisms with ischemic stroke and plasma lipid levels]. (PMID: 19350519) Wei Y.S. … Xie H.Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009) 3 22 46 65
  3. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction. (PMID: 16697311) Antoniades C. … Stefanadis C. (J. Am. Coll. Cardiol. 2006) 3 22 46 65
  4. Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer. (PMID: 16513317) Vairaktaris E. … Neukam F.W. (Eur J Surg Oncol 2006) 3 22 46 65
  5. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PMID: 15227729) Park S. … Jang Y. (Yonsei Med. J. 2004) 3 22 46 65

Products for ITGA2 Gene

Sources for ITGA2 Gene

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