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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA2 Gene

protein-coding   GIFtS: 68
GCID: GC05P052321

Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)


(Previous symbol: CD49B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)1 2     VLAA22
CD49B1 2 3 5     Human Platelet Alloantigen System 52
Collagen Receptor2 3     Integrin Alpha-22
Platelet Membrane Glycoprotein Ia2 3     Platelet Antigen Br2
GPIa2 3     Platelet Glycoprotein GPIa2
CD49 Antigen-Like Family Member B2 3     Very Late Activation Protein 2 Receptor, Alpha-2 Subunit2
BR2 5     VLA2 Receptor, Alpha-2 Subunit2
HPA-52     CD49b Antigen3
VLA-22     VLA-2 Subunit Alpha3

External Ids:    HGNC: 61371   Entrez Gene: 36732   Ensembl: ENSG000001641717   OMIM: 1929745   UniProtKB: P173013   

Export aliases for ITGA2 gene to outside databases

Previous GC identifers: GC05P052449 GC05P053715 GC05P052255 GC05P052301 GC05P049257


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA2 Gene:
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded
protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to
the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9.
Antibodies against this protein are found in several immune disorders, including neonatal alloimmune
thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for ITGA2 Gene: 
ITGA2 (integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)) is a protein-coding gene. Diseases associated with ITGA2 include glycoprotein 1a deficiency, and anus disease, and among its related super-pathways are Integrin-mediated cell adhesion and ECM-receptor interaction. GO annotations related to this gene include collagen binding and metal ion binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301
Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and
E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for
adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force
generation and organization of newly synthesized extracellular matrix

Gene Wiki entry for ITGA2 (CD49b) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA2 gene promoter:
         Sox5   FOXF2   POU2F1   POU2F1a   Nkx2-5   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

ITGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052321:  view genomic region     (about GC identifiers)

Start:
52,285,156 bp from pter      End:
52,390,609 bp from pter
Size:
105,454 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301 (See protein sequence)
Recommended Name: Integrin alpha-2 precursor  
Size: 1181 amino acids; 129295 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and
RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts
(via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains,
for which ITGA2 acts as a receptor
Subcellular location: Membrane; Single-pass type I membrane protein
4 PDB 3D structures from and Proteopedia for ITGA2:
1AOX (3D)        1DZI (3D)        1PQB (3D)        1V7P (3D)    
Secondary accessions: Q14595

Explore the universe of human proteins at neXtProt for ITGA2: NX_P17301

Explore proteomics data for ITGA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17301

  • ITGA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA2 Protein Expression
    REFSEQ proteins: NP_002194.2  
    ENSEMBL proteins: 
     ENSP00000296585   ENSP00000426489   ENSP00000422095   ENSP00000424397   ENSP00000424642  
     ENSP00000422145  
    Reactome Protein details: P17301
    Human Recombinant Protein Products for ITGA2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for ITGA2 (Integrin alpha 2 beta 1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ITGA2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ITGA2
    GenScript Custom Purified and Recombinant Proteins Services for ITGA2
    Novus Biologicals ITGA2 Protein
    Novus Biologicals ITGA2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009986cell surface IDA--
    GO:0045178basal part of cell IEA--

    ITGA2 for ontologies           About GeneDecksing



    ITGA2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA2
    R&D Systems Antibodies for ITGA2 (Integrin alpha 2/CD49b)
    OriGene Antibodies for ITGA2
    OriGene Custom Antibody Services for ITGA2
    GenScript Custom Superior Antibodies Services for ITGA2
    Novus Biologicals ITGA2 Antibodies
    Abcam antibodies for ITGA2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for ITGA2
    LSBio Antibodies in human, mouse, rat for ITGA2 

    Assay Products for ITGA2: 
    EMD Millipore Kits and Assays for the Analysis of ITGA2
    OriGene Custom Assay Services for ITGA2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ITGA2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5/6 InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P17301

    ProtoNet protein and cluster: P17301

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA2_HUMAN, P17301
    Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and
    E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for
    adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force
    generation and organization of newly synthesized extracellular matrix

         Genatlas biochemistry entry for ITGA2:
    integrin,alpha 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,component of VLA-2 receptor,dimerizing with ITGB1 in collagen,laminin receptors

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0005515protein binding IPI14681217
    GO:0005518collagen binding TAS9391074
    GO:0046872metal ion binding IEA--
         
    ITGA2 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Itga2):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  integument 
     normal 

    ITGA2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ITGA2: Itga2tm1Ztr Itga2tm1.1Eck

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA2:
    hsa-mir-30a (MIRT005123), hsa-mir-16 (MIRT001449)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA2 (see all 33):
    hsa-miR-2052 hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ITGA2
    Sirion Biotech Customized adenovirus for overexpression of ITGA2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ITGA2 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA2 (NM_002203)
    Sino Biological Human cDNA Clone for ITGA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA2 
                         Customized lentivirus expression plasmids for stable overexpression of ITGA2 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ITGA2
    Search LifeMap BioReagents cell lines for ITGA2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA2 About   (see all 41)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal Adhesion0.64
    Integrin-mediated cell adhesion0.38
    Focal adhesion0.64
    HGF Pathway0.34
    2Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    ECM proteoglycans0.38
    Syndecan interactions0.44
    Integrin cell surface interactions0.32
    ECM-receptor interaction0.42
    3Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    4Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for ITGA2
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling FAK signaling
    Cell adhesion Integrin inside-out signaling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    1 R&D Systems Pathway for ITGA2
        Articular Cartilage Extracellular Matrix

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA2 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    5 GeneGo (Thomson Reuters) Pathways for ITGA2
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cytoskeleton remodeling FAK signaling

    5/8 BioSystems Pathways for ITGA2 (see all 8)
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy
    Interleukin-11 Signaling Pathway
    VEGFR3 signaling in lymphatic endothelium


    5/12        Reactome Pathways for ITGA2 (see all 12)
        Hemostasis
    L1CAM interactions
    Platelet Adhesion to exposed collagen
    Developmental Biology
    Integrin cell surface interactions

    1 PharmGKB Pathway for ITGA2
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    5/12         Kegg Pathways  (Kegg details for ITGA2) (see all 12):
        Phagosome
    PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage


    ITGA2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/119 Interacting proteins for ITGA2 (P173011, 2, 3 ENSP000002965854) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIB1Q998282, 3, ENSP000003338734MINT-1894979 I2D: score=1 STRING: ENSP00000333873
    PDIA3P301012, 3MINT-4301430 I2D: score=1 
    ITGB1P055561, 3, ENSP000003640944EBI-702960,EBI-703066 I2D: score=3 STRING: ENSP00000364094
    COL1A2P081232, 3, ENSP000002972684MINT-4792053 I2D: score=2 STRING: ENSP00000297268
    WASLO004012, 3, ENSP000002230234MINT-1895068 I2D: score=1 STRING: ENSP00000223023
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10201960
    GO:0007160cell-matrix adhesion TAS2545729
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--

    ITGA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGA2 (ITA2)

    10/68 Novoseek inferred chemical compound relationships for ITGA2 gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bacteriorhodopsin 96.8 1488 15842995 (8), 16039842 (7), 8874028 (7), 12058039 (7) (see all 99)
    bacterioopsin 83.5 31 8652531 (3), 2344462 (2), 8580348 (2), 2350173 (1) (see all 8)
    convulxin 63.6 2 12881531 (1)
    hydrogen 58.3 147 15842995 (6), 8349659 (4), 10694399 (4), 15298873 (3) (see all 64)
    tyrosinate 54 6 1653012 (2), 2167129 (1), 2060632 (1)
    beta-ionone 52.2 1 8652531 (1)
    grgdsp 47.7 2 1331077 (1), 7843907 (1)
    matrigel 44.6 2 18554474 (1), 8985098 (1)
    adp 44.2 14 15850609 (1), 14734152 (1), 18253477 (1), 16381175 (1) (see all 10)
    fibrinogen 41.7 9 7503943 (1), 10168553 (1), 10554707 (1), 15665914 (1) (see all 9)

    2 PharmGKB related drug/compound annotations for ITGA2 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  
    clopidogrelCA  

    Search CenterWatch for drugs/clinical trials and news about ITGA2 / ITA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA2 gene: 
    NM_002203.3  

    Unigene Cluster for ITGA2:

    Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
    Hs.482077  [show with all ESTs]
    Unigene Representative Sequence: NR_073105
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296585(uc003joy.3 uc011cqa.2 uc011cqb.2 uc011cqc.2 uc011cqd.2 uc011cqe.2)
    ENST00000503810 ENST00000513685 ENST00000509814 ENST00000509960 ENST00000510722

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA2
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA2 (see all 33):
    hsa-miR-2052 hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-424
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    Clone
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    OriGene clones in human, mouse for ITGA2 (see all 7)
    OriGene ORF clones in mouse, rat for ITGA2
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    GenScript: all cDNA clones in your preferred vector: ITGA2 (NM_002203)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA2
    Sirion Biotech Customized lentivirus for stable overexpression of ITGA2 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA2

    Additional mRNA sequence: 

    AK307952.1 BC143505.1 BC143508.1 BC143509.1 BC143511.1 BC143512.1 NR_073103.1 NR_073104.1 
    NR_073105.1 NR_073106.1 NR_073107.1 X17033.1 

    7 DOTS entries:

    DT.113328  DT.97818767  DT.40296409  DT.91687975  DT.40126600  DT.97806649  DT.91827777 

    24/135 AceView cDNA sequences (see all 135):

    AA307466 BM798135 CA419950 BQ000380 BG771368 BM979113 AI261712 CA442768 
    AA236162 AA366887 AA532551 BU632208 AI355720 BM987549 AI339858 BU676023 
    CK904146 CB241295 AA993294 AI309192 AI538195 BM826223 CA444519 AA991803 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                          -     -                                                                                                                           

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                          
    SP2:                                          


    ECgene alternative splicing isoforms for ITGA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA2 expression in normal human tissues (normalized intensities)      ITGA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTACAAA
    ITGA2 Expression
    About this image


    ITGA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow Stromal Cells Bone Marrow
             Bone marrow-derived adherent progenitor cells (MultiStem)
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             HNK1+p75+ cells ( Derivation of neural crest cells and their progeny (MS-5 feeder...
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Basophils Peripheral Blood
     
     Adipose (Muscoskeletal System)
             Human multipotent adipose-derived (hMAD) stem cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H7 (WA07)

    See ITGA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA2

    SOURCE GeneReport for Unigene cluster: Hs.482077
        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA2 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Atherosclerosis in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga21 , 5 integrin alpha 21, 5 83.08(n)1
    82.51(a)1
      13 (64.61 cM)5
    163981  NM_008396.21  NP_032422.21 
     1148359165 
    chicken
    (Gallus gallus)
    Aves LOC1008572271 integrin alpha-2-like 70.18(n)
    66.84(a)
      100857227  XM_003642982.1  XP_003643030.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA26
    integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2...
    64(a)
    1 ↔ 1
    2(3554627-3627202)
    African clawed frog
    (Xenopus laevis)
    Amphibia itga2-A2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more 74.77(n)    L43058.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005365331 integrin alpha-2-like 57.08(n)
    51.74(a)
      100536533  XM_003199304.1  XP_003199352.1 


    ENSEMBL Gene Tree for ITGA2 (if available)
    TreeFam Gene Tree for ITGA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA2 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  
    12 SIMAP similar genes for ITGA2 using alignment to 13 protein entries:     ITA2_HUMAN (see all proteins):
    ITGA1    VIT    ITGA11    ITGA10    ITGAX    COL21A1
    COL6A6    COL14A1    MATN2    COL12A1    COL22A1    COL6A3

    ITGA2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301
    Polymorphism: Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534
    and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The
    Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD)


    10/2320 SNPs in ITGA2 are shown (see all 2320)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998084991,2
    Cuntested152295449(+) TTACTA/CTCAAA 7 I L nc-transcript-variantmis11Minor allele frequency- C:0.00EU 1317
    rs1995568161,2
    --49257722(+) CACAC-/AGACAGA 6 -- int10--------
    rs401181,2
    C,H--49257723(+) ACACAC/GACAGA 6 -- int12Minor allele frequency- G:0.00NA 4
    rs2012088221,2
    --49259886(+) TTCCA-/CCCCAG 6 -- int10--------
    rs19462681,2
    C,H--49290096(-) cccccA/Caaaaa 6 -- int10--------
    rs1389755651,2
    C--49290096(+) ttttt-/G/Tggggg 6 -- int11NA 2
    rs718172141,2
    C--49303922(+) TCGTA-/ATTC  
            
    TTCAT
    6 -- int10--------
    rs114214191,2
    C--49312161(+) AAAAAA/-AAAAA 6 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs2014242141,2
    C--49312186(-) CCTTTC/TTTTTT 6 -- int10--------
    rs1432924261,2
    C--49352171(+) TTTTT-/TCTTTT 6 -- int10--------

    HapMap Linkage Disequilibrium report for ITGA2 (52285156 - 52390609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/28 variations for ITGA2 (see all 28):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv6057n71CNV Loss21882294
    dgv6052n71CNV Loss21882294
    dgv6053n71CNV Loss21882294
    nsv881652CNV Loss21882294
    dgv6055n71CNV Loss21882294
    nsv880425CNV Loss21882294
    nsv881217CNV Loss21882294
    dgv6061n71CNV Loss21882294
    dgv6059n71CNV Loss21882294
    dgv6056n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): ITGA2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 192974    OMIM disorders: --

    20/110 diseases for ITGA2 (see all 110):    About MalaCards
    glycoprotein 1a deficiency    anus disease    thrombocytopenia    glanzmann's thrombasthenia
    thrombasthenia    gingival overgrowth    osteomyelitis    septic arthritis
    autoimmune thrombocytopenic purpura    bernard-soulier syndrome    retinal vein occlusion    alport syndrome
    heparin-induced thrombocytopenia    thromboembolism    gingivitis    von willebrand's disease
    brucellosis    appendicitis    sickle cell anemia    thrombosis

    6 diseases from the University of Copenhagen DISEASES database for ITGA2:
    Brucellosis     Progressive myoclonus epilepsy     Cancer     Thrombocytopenia
    Anus disease     Appendicitis

    ITGA2 for disorders           About GeneDecksing

    10/62 Novoseek inferred disease relationships for ITGA2 gene (see all 62)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arterial thrombosis 43.7 2 20076847 (1), 9701455 (1)
    collagen fibril 38.9 1 16854461 (1)
    glanzmann thrombasthenia 35.5 1 10097812 (1)
    metastasis 32.1 23 19738067 (4), 7681030 (2), 2011740 (1), 9306710 (1) (see all 13)
    thrombosis 26.5 3 17164499 (1), 18045662 (1), 12617110 (1)
    bernard-soulier syndrome 26.4 1 10097812 (1)
    osteosarcoma 25 3 8326445 (1), 9716443 (1)
    rhabdomyosarcoma 21.5 6 2011740 (2), 9306710 (1), 8674074 (1), 7630001 (1)
    colon carcinoma 18.9 4 18098323 (1), 11169447 (1), 2304917 (1)
    colon cancer 17.1 4 12657625 (2), 15304500 (1), 18664572 (1)

    Genatlas disease: ITGA2
    neonatal alloimmune thrombocytopenia

    Genetic Association Database (GAD): ITGA2
    Human Genome Epidemiology (HuGE) Navigator: ITGA2 (123 documents)

    Export disorders for ITGA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA2 gene, integrated from 9 sources (see all 802):
    (articles sorted by number of sources associating them with ITGA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. (PubMed id 16317580)1, 4, 9 Langsenlehner U....Krippl P. (2006)
    2. Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PubMed id 15227729)1, 4, 9 Park S....Jang Y. (2004)
    3. [Association of the integrin gene polymorphisms with ischemic stroke and plasma lipid levels.] (PubMed id 19350519)1, 4, 9 Wei Y....Xie H. (2009)
    4. Genetic polymorphisms of platelet glycoprotein Ia and the risk for premature myocardial infarction: effects on the release of sCD40L during the acute phase of premature myocardial infarction. (PubMed id 16697311)1, 4, 9 Antoniades C....Stefanadis C. (2006)
    5. Association of platelet glycoprotein Ia polymorphism with minor increase of risk for oral cancer. (PubMed id 16513317)1, 4, 9 Vairaktaris E....Neukam F.W. (2006)
    6. Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. (PubMed id 15978109)1, 4, 9 Di Paola J....Murray J.C. (2005)
    7. Polymorphisms in platelet glycoproteins Ia and IIIa a re associated with arterial thrombosis and carotid atherosclerosis in type 2 di abetes. (PubMed id 20076847)1, 4, 9 Pellitero S....Reverter J.C. (2010)
    8. Genetics of platelet reactivity in normal, healthy in dividuals. (PubMed id 19740098)1, 4, 9 Kunicki T.J....Nugent D.J. (2009)
    9. Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment. (PubMed id 17157856)1, 4, 9 Giusti B....Abbate R. (2008)
    10. Association of integrin alpha2 gene variants with ischemic stroke. (PubMed id 17534386)1, 4, 9 Matarin M.... . (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3673 HGNC: 6137 AceView: ITGA2 Ensembl:ENSG00000164171 euGenes: HUgn3673
    ECgene: ITGA2 Kegg: 3673 H-InvDB: ITGA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGA2
    SeattleSNPshttp://pga.gs.washington.edu/data/itga2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA2 gene:
    Search GeneIP for patents involving ITGA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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