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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGA2 Gene

protein-coding GIFtS: 66
GCID: GC05P052321

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

(Previous symbol: CD49B)

Explore 115 diseases affiliated with
ITGA2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)¹ ²		VLAA2²
CD49B¹ ² ³ ⁵		Human Platelet Alloantigen System 5²
Collagen Receptor² ³		Integrin Alpha-2²
Platelet Membrane Glycoprotein Ia² ³		Platelet Antigen Br²
GPIa² ³		Platelet Glycoprotein GPIa²
CD49 Antigen-Like Family Member B² ³		Very Late Activation Protein 2 Receptor, Alpha-2 Subunit²
BR² ⁵		VLA2 Receptor, Alpha-2 Subunit²
CD49b¹		CD49b Antigen³
HPA-5²		VLA-2 Subunit Alpha³
VLA-2²

External Ids:	HGNC: 6137¹	Entrez Gene: 3673²	Ensembl: ENSG00000164171⁷	OMIM: 192974⁵	UniProtKB: P17301³

Export aliases for ITGA2 gene to outside databases

Previous GC identifers: GC05P052449 GC05P053715 GC05P052255 GC05P052301 GC05P049257

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA2:

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein

forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the

extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies

against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene

is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

(provided by RefSeq, Aug 2012)

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and

E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of

platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and

organization of newly synthesized extracellular matrix

Gene Wiki entry for ITGA2 (CD49b)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGA2 gene promoter:
Sox5 FOXF2 POU2F1 POU2F1a Nkx2-5 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGA2 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGA2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

ITGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA2 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P052321: view genomic region (about GC identifiers)

Start:	52,285,156 bp from pter	End:	52,390,609 bp from pter
Size:	105,454 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301 (See protein sequence)

Recommended Name: Integrin alpha-2 precursor

Size: 1181 amino acids; 129295 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.

Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for these viruses. Interacts (via ITAG2

I-domain) with rotavirus A VP4; this interaction only occurs in rotavirus integrin-dependent strains, for which ITGA2

acts as a receptor

Subcellular location: Membrane; Single-pass type I membrane protein

4 PDB 3D structures from and Proteopedia for ITGA2:

1AOX (3D)

1DZI (3D)

1PQB (3D)

1V7P (3D)

Secondary accessions: Q14595

Explore the universe of human proteins at neXtProt for ITGA2: NX_P17301

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P17301

ITGA2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002194.2

ENSEMBL proteins:

ENSP00000296585 ENSP00000426489 ENSP00000422095 ENSP00000424397 ENSP00000424642

ENSP00000422145

Reactome Protein details: P17301
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for ITGA2 (Integrin alpha 2 beta 1)
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	Novus Biologicals ITGA2 Protein Novus Biologicals ITGA2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--
GO:0009897	external side of plasma membrane	IEA	--
GO:0009986	cell surface	IDA	--
GO:0045178	basal part of cell	IEA	--

ITGA2 for ontologies About GeneDecksing

ITGA2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA2
	R&D Systems Antibodies for ITGA2 (Integrin alpha 2/CD49b)
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	Abcam antibodies for ITGA2
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for ITGA2

Assay Products for ITGA2:

	EMD Millipore Kits and Assays for the Analysis of ITGA2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ITGA2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGA2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR018184 Integrin_alpha_C_CS

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

Graphical View of Domain Structure for InterPro Entry P17301

ProtoNet protein and cluster: P17301

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and

E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of

platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and

organization of newly synthesized extracellular matrix

Genatlas biochemistry entry for ITGA2:

integrin,alpha 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,component of VLA-2 receptor,dimerizing with ITGB1 in collagen,laminin receptors

miRNA Products:		miRTarBase miRNAs that target ITGA2: hsa-mir-30a (MIRT005123), hsa-mir-16 (MIRT001449)

		OriGene 3'-UTR Clone: ITGA2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA2
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA2 (see all 33):
		hsa-miR-2052 hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-424

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA2 (see all 4) OriGene shRNA RFP: ITGA2 OriGene siRNA: ITGA2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGA2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: ITGA2 (NM_002203)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGA2
		Search LifeMap BioReagents cell lines for ITGA2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	IPI	--
GO:0005518	collagen binding	TAS	9391074
GO:0046872	metal ion binding	IEA	--

ITGA2 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ITGA2: Itga2^tm1.1Eck Itga2^tm1Ztr
     6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Itga2):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	integument
normal

ITGA2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Integrin outside-in signaling	0.37
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
Cytoskeleton remodeling_Integrin outside-in signaling	0.37	Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for ITGA2

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Integrin outside-in signaling
	Cytoskeleton remodeling FAK signaling
	Cell adhesion Integrin inside-out signaling
	Cell adhesion Endothelial cell contacts by non-junctional mechanisms

1 R&D Systems Pathway for ITGA2

Articular Cartilage Extracellular Matrix

5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA2 (see all 33)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

5 GeneGo (Thomson Reuters) Pathways for ITGA2

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Integrin inside-out signaling
	Cytoskeleton remodeling FAK signaling

5/8 BioSystems Pathways for ITGA2 (see all 8)

	Focal Adhesion
	Integrin-mediated cell adhesion
	Arrhythmogenic right ventricular cardiomyopathy
	Interleukin-11 Signaling Pathway
	Syndecan-2-mediated signaling events

5/8 Reactome Pathways for ITGA2 (see all 8)

	Hemostasis
	L1CAM interactions
	Platelet Adhesion to exposed collagen
	Developmental Biology
	Integrin cell surface interactions

1 PharmGKB Pathway for ITGA2

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

5/10 Kegg Pathways (Kegg details for ITGA2) (see all 10):

	Phagosome
	Focal adhesion
	ECM-receptor interaction
	Hematopoietic cell lineage
	Regulation of actin cytoskeleton

ITGA2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGA2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/119 Interacting proteins for ITGA2 (P17301^{1, 2, 3} ENSP00000296585⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 119)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CIB1	Q99828²^,³, ENSP00000333873⁴	MINT-1894979 I2D: score=1 STRING: ENSP00000333873
PDIA3	P30101²^,³	MINT-4301430 I2D: score=1
ITGB1	P05556¹^,³, ENSP00000364094⁴	EBI-702960,EBI-4289597 I2D: score=3 STRING: ENSP00000364094
COL1A2	P08123²^,³, ENSP00000297268⁴	MINT-4792053 I2D: score=2 STRING: ENSP00000297268
WASL	O00401²^,³, ENSP00000223023⁴	MINT-1895068 I2D: score=1 STRING: ENSP00000223023

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	10942362
GO:0007160	cell-matrix adhesion	TAS	2545729
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0007596	blood coagulation	TAS	--

ITGA2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ITGA2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGA2
10/68 Novoseek chemical compound relationships for ITGA2 gene (see all 68) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bacteriorhodopsin	96.8	1488	15842995 (8), 16039842 (7), 8874028 (7), 12058039 (7) (see all 99)
bacterioopsin	83.5	31	8652531 (3), 2344462 (2), 8580348 (2), 2350173 (1) (see all 8)
convulxin	63.6	2	12881531 (1)
hydrogen	58.3	147	15842995 (6), 8349659 (4), 10694399 (4), 15298873 (3) (see all 64)
tyrosinate	54	6	1653012 (2), 2167129 (1), 2060632 (1)
beta-ionone	52.2	1	8652531 (1)
grgdsp	47.7	2	1331077 (1), 7843907 (1)
matrigel	44.6	2	18554474 (1), 8985098 (1)
adp	44.2	14	15850609 (1), 14734152 (1), 18253477 (1), 16381175 (1) (see all 10)
fibrinogen	41.7	9	7503943 (1), 10168553 (1), 10554707 (1), 15665914 (1) (see all 9)

Search CenterWatch for drugs/clinical trials and news about ITGA2 / ITA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGA2 gene:

NM_002203.3

Unigene Cluster for ITGA2:

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Hs.482077 [show with all ESTs]

Unigene Representative Sequence: NR_073105

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296585(uc003joy.3 uc011cqa.2 uc011cqb.2 uc011cqc.2 uc011cqd.2 uc011cqe.2)

ENST00000503810 ENST00000513685 ENST00000509814 ENST00000509960 ENST00000510722

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA2
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA2 (see all 33):
		hsa-miR-2052 hsa-miR-607 hsa-miR-513a-5p hsa-miR-15a hsa-miR-128 hsa-miR-3074-3p hsa-miR-219-5p hsa-miR-424

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA2

Additional cDNA sequence:

AK307952.1 BC143505.1 BC143508.1 BC143509.1 BC143511.1 BC143512.1 NR_073103.1 NR_073104.1

NR_073105.1 NR_073106.1 NR_073107.1 X17033.1

7 DOTS entries:

DT.113328 DT.97818767 DT.40296409 DT.91687975 DT.40126600 DT.97806649 DT.91827777

24/135 AceView cDNA sequences (see all 135):

BU676023 AA991803 CK904146 BQ000380 BM826223 BQ101227 CK904145 BQ001409

CK823194 AA236162 BM979113 BG771368 AI309192 AA993294 BU632208 AI339858

AI261712 CA442768 BM798135 AI538195 CA419950 AA366887 AA307466 CB241295

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:
SP2:									-		-

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30
SP1:
SP2:

ECgene alternative splicing isoforms for ITGA2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTACAAA

About this image

ITGA2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

Human multipotent adipose-derived (hMAD) stem cells (Adult Stem / Progenitor Cell)

Adipose

Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)

Bone

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

HNK1+p75+ cells (Derivation of neural...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITGA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGA2

SOURCE GeneReport for Unigene cluster: Hs.482077

SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA2 (see all 8):

Osteogenesis in human mouse rat

Fibrosis in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Cell Surface Markers in human mouse rat

Atherosclerosis in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA2

In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ITGA2 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Itga2^{1 , 5}	integrin alpha 2^{1, 5}	83.08(n)¹ 82.51(a)¹		13 (64.61 cM)⁵ 16398¹ NM_008396.2¹ NP_032422.2¹ 114835916⁵
chicken (Gallus gallus)	Aves	LOC100857227¹	integrin alpha-2-like	70.18(n) 66.84(a)		100857227 XM_003642982.1 XP_003643030.1
lizard (Anolis carolinensis)	Reptilia	ITGA2⁶ --	--	65(a) 20(a)	1 ↔ 1 possible ortholog	2(3558188-3607361) GL343516.1(252432-271527)
African clawed frog (Xenopus laevis)	Amphibia	itga2-A²	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more	74.77(n)		L43058.1
zebrafish (Danio rerio)	Actinopterygii	LOC100536533¹	integrin alpha-2-like	57.08(n) 51.74(a)		100536533 XM_003199304.1 XP_003199352.1
fruit fly (Drosophila melanogaster)	Insecta	alphaPS5⁶ scb⁶ (see all 3)	scab (see all 3)	18(a) 16(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(19444333-19447720) 2R(11136290-11146003)

ENSEMBL Gene Tree for ITGA2 (if available)
TreeFam Gene Tree for ITGA2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ITGA2 gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA11² ITGA5²

ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGAL² ITGA9² ITGA4²

ITGA10²

13 SIMAP similar genes for ITGA2 using alignment to 13 protein entries: ITA2_HUMAN (see all proteins):

ITGA1 VIT ITGA11 ITGA10 ITGAX COL21A1

COL6A6 COL14A1 MATN2 COL12A1 COL22A1 COL6A3

COL20A1

ITGA2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Polymorphism: Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and

HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu

polymorphism may play a role in coronary artery disease (CAD)

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199808499^1,2	C	untested	49330800(+)	`TTACTA/CTCAAA`	7	I L	nc-transcript-variantmis¹		1		EU	1317
rs78034781^1,2	F,	--	49255249(+)	`AGGATT/CTTTGT`	6	--	us2k¹		1		WA	118
rs75388226^1,2	F,	--	49255360(+)	`CTGCAA/CCTAGG`	6	--	us2k¹		1		WA	118
rs75178561^1,2		--	49255379(+)	`CACCCC/TGGAAG`	6	--	us2k¹		0	--	--	--	--
rs3212384^1,2	C,	--	49256382(+)	`AGAATG/ATTCTC`	6	--	us2k¹		2		NS	92
rs5867857^1,2	C,	--	49256599(+)	`TCTGT-/CAcacac`	6	--	us2k¹		0	--	--	--	--
rs27646^1,2	C,	--	49257133(+)	`GCGGCC/GGGAGC`	6	--	us2k¹		3		NA CSA WA	122
rs28095^1,2	C,F,A,H,	--	49257173(+)	`CGGGCC/TGGGGC`	6	--	us2k¹		9		NS MN NA CSA WA EA	640
rs3212385^1,2	C,F,	--	49257231(+)	`ACCGGG/ACGGGG`	6	--	nc-transcript-variantut5¹		10		NS CSA WA	857
rs75823056^1,2	F,	--	49257509(+)	`GGAGCG/AAGCTC`	6	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for ITGA2 (52285156 - 52390609 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ITGA2: --
Human Gene Mutation Database (HGMD): ITGA2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGA2 for disorders           About GeneDecksing

OMIM gene information: 192974    OMIM disorders: --

20/115 diseases for ITGA2 (see all 115):    About MalaCards

neonatal alloimmune thrombocytopenia bleeding disorder thrombocytopenia heparin-induced thrombocytopenia

glanzmann's thrombasthenia glycoprotein ia deficiency patent ductus arteriosus wiskott-aldrich syndrome

gingival overgrowth lichen planus autoimmune thrombocytopenic purpura von willebrand's disease

retinal vein occlusion oral lichen planus pre-eclampsia thrombasthenia

coronary heart disease myocardial infarction polycythemia vera amyotrophic lateral sclerosis

6 diseases from the University of Copenhagen DISEASES database for ITGA2:

Brucellosis Cancer Thrombocytopenia Anus disease

Appendicitis Vascular disease

10/62 Novoseek disease relationships for ITGA2 gene (see all 62) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arterial thrombosis	43.7	2	20076847 (1), 9701455 (1)
collagen fibril	38.9	1	16854461 (1)
glanzmann thrombasthenia	35.5	1	10097812 (1)
metastasis	32.1	23	19738067 (4), 7681030 (2), 2011740 (1), 9306710 (1) (see all 13)
thrombosis	26.5	3	17164499 (1), 18045662 (1), 12617110 (1)
bernard-soulier syndrome	26.4	1	10097812 (1)
osteosarcoma	25	3	8326445 (1), 9716443 (1)
rhabdomyosarcoma	21.5	6	2011740 (2), 9306710 (1), 8674074 (1), 7630001 (1)
colon carcinoma	18.9	4	18098323 (1), 11169447 (1), 2304917 (1)
colon cancer	17.1	4	12657625 (2), 15304500 (1), 18664572 (1)

Genatlas disease: ITGA2

neonatal alloimmune thrombocytopenia

Genetic Association Database (GAD): ITGA2
Human Genome Epidemiology (HuGE) Navigator: ITGA2 (123 documents)

Export disorders for ITGA2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ITGA2 gene, integrated from 9 sources (see all 779):
(articles sorted by number of sources associating them with ITGA2)

Utopia: connect your pdf to the dynamic
world of online information

Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. (PubMed id 16317580)^{1, 4, 9} Langsenlehner U....Krippl P. (2006)
Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PubMed id 15227729)^{1, 4, 9} Park S....Jang Y. (2004)
Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. (PubMed id 15978109)^{1, 4, 9} Di Paola J....Murray J.C. (2005)
Glycoprotein Ia 807TT/873AA genotype is not associated with myocardial infarction. (PubMed id 16140647)^{1, 4, 9} Komurcu E....Erginel-Unaltuna N. (2005)
Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth. (PubMed id 16304451)^{1, 4, 9} Ogino M....Kataoka M. (2005)
Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. (PubMed id 12540964)^{1, 4, 9} Reiner A.P....Agardh C.D. (2003)
Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men. (PubMed id 11812069)^{1, 4, 9} Benze G....Junker R. (2002)
Role of 4 platelet membrane glycoprotein polymorphisms on experimental arterial thrombus formation in men. (PubMed id 11698306)^{1, 4, 9} Cadroy Y....Sie P. (2001)
The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2). (PubMed id 7901236)^{1, 2, 9} Santoso S....Newman P.J. (1993)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3673	HGNC: 6137	AceView: ITGA2	Ensembl:ENSG00000164171	euGenes: HUgn3673
ECgene: ITGA2	Kegg: 3673	H-InvDB: ITGA2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ITGA2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGA2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ITGA2
SeattleSNPs	http://pga.gs.washington.edu/data/itga2/

Intellectual Property for ITGA2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGA2 gene:
Search GeneIP for patents involving ITGA2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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ITGA2 Gene

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

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ITGA2 (Gene Symbol)
Integrin, Alpha 2 (CD49B, Alpha 2 Subunit Of VLA-2 Receptor)
CD49B
Collagen Receptor
Platelet Membrane Glycoprotein Ia
GPIa
CD49 Antigen-Like Family Member B
BR
CD49b
HPA-5
VLA-2
VLAA2
Human Platelet Alloantigen System 5
Integrin Alpha-2
Platelet Antigen Br
Platelet Glycoprotein GPIa
Very Late Activation Protein 2 Receptor, Alpha-2 Subunit
VLA2 Receptor, Alpha-2 Subunit
CD49b Antigen
VLA-2 Subunit Alpha

Gastric Cancer
Down Syndrome
BREAST CARCINOMA
Melanoma
Chondrosarcoma
Colon Cancer
Hyperplasia
Osteomyelitis
Carcinoma Basal Cell
coagulopathy
dysplasia
Carcinoma
COLON CARCINOMA
retinopathy
PROSTATE CARCINOMA
Diabetes Mellitus
Osteosarcoma
Breast Cancer
Neovascularization
Diabetic Retinopathy
Asthma
Adenocarcinoma
metastatic melanoma
Cancer
Rhabdomyosarcoma
Arthritis Septic
Cancer Lung
Thrombocytopenia
small cell lung cancer
Myocardial Infarction
Coronary Artery Disease
GASTRIC CARCINOMA
RENAL DISEASE
Ovarian Cancer
ARTERIAL THROMBOSIS
Bleeding
ADPKD
Inflammation
OVARIAN CARCINOMA
Carcinoma Squamous Cell
Cysts
Oral Cancer
BLADDER CARCINOMA
Hypertrophy
Glanzmann Thrombasthenia
MYELOMA
STROKE
Rheumatoid Arthritis
PANCREATIC CARCINOMA
Bernard-Soulier Syndrome
Vascular Diseases
prostate cancer
Cardiovascular Diseases
Tumors
Metastasis
Thrombosis
Gingival Overgrowth
Necrosis
Fibrosarcoma
Collagen fibril
Coronary Heart Disease
Thromboembolism

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ITGA2 Gene

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

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