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ITGA2 Gene

protein-coding GIFtS: 68

GC05P052321

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CD49B)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BR ^², ⁵
CD49B ^², ³, ⁵
CD49b ^¹
GPIa ^², ³
VLA-2 ^²
VLAA2 ^²

Descriptions
CD49 antigen-like family member B ^³
CD49b antigen ^³
Collagen receptor ^³
Platelet membrane glycoprotein Ia ^³
VLA-2 alpha chain ^³
integrin alpha 2 ^²
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) ^²
platelet antigen Br ^²
platelet glycoprotein GPIa ^²
platelet glycoprotein Ia ^²
very late activation protein 2 receptor, alpha-2 subunit ^²

External Ids
HGNC: 6137¹
Entrez Gene: 3673²
UniProtKB: P17301³
Ensembl: ENSG00000164171⁷

Search outside databases for aliases for ITGA2 gene

Previous GC identifers: GC05P052449 GC05P053715 GC05P052255 GC05P052301

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ITGA2:

This gene product belongs to the integrin alpha chain family. Integrins are heterodimeric integral

membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found

on a wide variety of cell types including, T cells, fibroblasts and platelets. Integrins are

involved in cell adhesion and also participate in cell-surface mediated signalling. [provided by

RefSeq]

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides,

fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in

collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of

collagen and collagenase gene expression, force generation and organization of newly synthesized

extracellular matrix

Gene Wiki entry for ITGA2 (CD49b)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ITGA2 gene

Entrez Gene cytogenetic band: 5q23-q31 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2

ITGA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P052321: (about GC identifiers)

Start:	52,320,913 bp from pter
End:	52,426,366 bp from pter
Size:	105,454 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_006713.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301 (See protein sequence)

Recommended Name: Integrin alpha-2 precursor

Size: 1181 amino acids; 129295 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with

HPS5 and RAB21. Binds to human echoviruses 1 and 8 capsid proteins and acts as a receptor for

these viruses. Interacts (via ITAG2 I-domain) with rotavirus A VP4; this interaction only occurs

in rotavirus integrin-dependent strains, for which ITGA2 acts as a receptor

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1AOX (3D)

1DZI (3D)

1PQB (3D)

1V7P (3D)

Secondary accessions: Q14595

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002194.2

ENSEMBL proteins:

ENSP00000296585

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Integrin alpha 2, Integrin alpha 2+beta 1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	1763388 2545729
GO:0008305	integrin complex	TAS	2545729
GO:0009897	external side of plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ITGA2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of ITGA2
	Sigma-Aldrich Antibodies for ITGA2
	R&D Systems Antibodies for ITGA2 (Integrin alpha 2/CD49b)
	Antibodies from Abcam (Integrin alpha 2, Integrin alpha 2+beta 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for ITGA2

Assays for ITGA2:

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of ITGA2
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P17301

ProtoNet protein and cluster: P17301

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo

protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ITGA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ITGA2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002203

Applied Biosystems Silencer® siRNAs for ITGA2

Sigma-Aldrich siRNA and siRNA Panels for ITGA2

Sigma-Aldrich shRNA Panels and shRNA for ITGA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002203
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002203
untagged cDNA clone in CMV expression vector: NM_002203

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002203

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides,

fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in

collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of

collagen and collagenase gene expression, force generation and organization of newly synthesized

extracellular matrix

Genatlas biochemistry entry for ITGA2:

integrin,alpha 2,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or

to other cells,through hetero dimerization and connecting to the cytoskeleton and various

signaling molecules within cells,component of VLA-2 receptor,dimerizing with ITGB1 in

collagen,laminin receptors

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Itga2):

cellular	endocrine/exocrine gland	hematopoietic system	homeostasis/metabolism	normal
reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0004872	receptor activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005518	collagen binding	TAS	9391074
GO:0042802	identical protein binding	IPI	14681217

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/15 Sigma-Aldrich "Your Favorite Gene" Pathways for ITGA2 (Your Favorite Gene powered by Ingenuity) (see all 15 )

Caveolar-mediated Endocytosis
Neuregulin Signaling
Ephrin Receptor Signaling
Reelin Signaling in Neurons
NF-&kappa

GeneDecks ITGA2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ITGA2

5/134 Interacting proteins for ITGA2 (ENSP00000296585³ P17301^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 134 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
COL1A2	P08123²	STRING (score=.99) MINT-4792053
ITGA2	P17301¹	EBI-702960, EBI-702960
CIB1	Q99828²	MINT-1894979
PDIA3	P30101²	MINT-4301430
WASL	O00401²	MINT-1895068

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	10201960 10942362
GO:0007160	cell-matrix adhesion	TAS	2545729
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007596	blood coagulation	TAS	2933589
GO:0009887	organ morphogenesis	TAS	9391074

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ITGA2
10/45 Novoseek chemical compound relationships for ITGA2 gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bacteriorhodopsin	96.77	1404	15842995 (8), 16039842 (7), 8874028 (7), 12058039 (7) (see all 99)
bacterioopsin	83.99	31	8652531 (3), 2344462 (2), 8580348 (2), 2350173 (1) (see all 8)
convulxin	65.19	2	12881531 (1)
hydrogen	59.16	143	15842995 (6), 8349659 (4), 10694399 (4), 15298873 (3) (see all 62)
tyrosinate	54.96	6	1653012 (2), 2167129 (1), 2060632 (1)
beta-ionone	54.26	1	8652531 (1)
matrigel	46.64	2	18554474 (1), 8985098 (1)
adp	43.63	13	15850609 (1), 14734152 (1), 18253477 (1), 16381175 (1) (see all 9)
fibrinogen	43.21	9	7503943 (1), 10168553 (1), 10554707 (1), 15665914 (1) (see all 9)
grgdsp	40.86	1	1331077 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ITGA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ITGA2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002203

Sigma-Aldrich siRNA and siRNA Panels for ITGA2

Sigma-Aldrich shRNA Panels and shRNA for ITGA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002203

REFSEQ mRNAs for ITGA2 gene:

NM_002203.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002203

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002203
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002203
                                 untagged cDNA clone in CMV expression vector: NM_002203

Additional cDNA sequence:

AK307952.1 BC143505.1 BC143508.1 BC143509.1 BC143511.1 BC143512.1 X17033.1

7 DOTS entries:

DT.113328 DT.97818767 DT.40296409 DT.91687975 DT.40126600 DT.97806649 DT.91827777

24/135 AceView cDNA sequences (see all 135 ):

CA419950 BU632208 BQ001409 BM826223 BM798135 CK904145 BU676023 BU782863

BQ000380 AA307466 AA991803 BG771368 AI309192 CK904146 AI339858 AI538195

AA236162 BQ101227 CB241295 AA532551 BM987549 CK823194 CA442768 BM979113

highest scoring ESTs for ITGA2:

X17033 AA069027 AA069096 AA186802 AA236162 AA236687 AA307466 AA311146 AA362330 AA366875

Unigene Cluster for ITGA2:

Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

Hs.482077 [show with all ESTs]

Unigene Representative Sequence: NM_002203

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA2

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^
SP1:
SP2:									-		-

ExUns:	24	^	25	^	26	^	27	^	28	^	29	^	30
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for ITGA2

1 Ensembl transcript including schematic representation:

ENST00000296585

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ITGA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ITGA2

¹ / ² / ³

7 probe-sets matching ITGA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
46919_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	N95414	0.60	1.00	0.82	1
1978_at²^{, 3}	U95-A	1	1.00	1.00	-0.13	0.28	X17033	1.00	0.90	0.95	1
41481_at²^{, 3}	U95-A	1	1.00	1.00	0.50	0.47	X17033	1.00	0.90	0.95	1
205032_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002203	0.60	1.00	0.82	1
227314_at²^{, 3}	U133-B	1	1.00	1.00	--	--	N95414	0.60	1.00	0.82	1
205032_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
227314_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTGTACAAA

SOURCE GeneReport for Unigene cluster: Hs.482077

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ITGA2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ITGA2¹	--	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more	88.61(n) 87.09(a)	489208 XM_546326.2 XP_546326.2
chimpanzee (Pan troglodytes)	ITGA2¹	--	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more	99.55(n) 99.66(a)	471550 XM_526928.2 XP_526928.2
cow (Bos taurus)	ITGA2¹	--	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 more	88.15(n) 86.51(a)	281872 XM_613651.3 XP_613651.3
rat (Rattus norvegicus)	Itga2¹	--	integrin, alpha 2	83.28(n) 81.75(a)	170921 XM_345156.3 XP_345157.3
mouse (Mus musculus)	Itga2^{1, 5}	13 (64.00 cM)⁵	integrin alpha 2^{1, 5}	83.08(n)¹ 82.51(a)¹	16398¹ NM_008396.2¹ NP_032422.2¹ AK036572⁵ AK051050⁵ (see all 9)

About this table Species with no ortholog for ITGA2

ENSEMBL Gene Tree for ITGA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ITGA2 gene

ITGA1² ITGA11² ITGA10²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ITA2_HUMAN, P17301

Polymorphism: Position 534 is associated with platelet-specific alloantigen HPA-5 (Br).

HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune

thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery

disease (CAD)

10/833 NCBI SNPs in ITGA2 are shown (see all 833 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 425)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1042324^1,2	A,C,F,H,O	52423438(+)	`AGTAAG/AACATC`	1	--	ut3¹		7	NA EU EA WA	562
	rs26680^1,2	A,C,F,H,O	52320143(+)	`TGTCAC/TGGTGT`	1	--	ng5¹		25	EU EA WA NS NA	3502
	rs26679^1,2	A,C,F,H,O	52319932(+)	`CAGTTG/CGTTCC`	1	--	ng5¹		28	MN EU EA WA NS NA	4084
	rs7725246^1,2	A,C,F,H	52426172(+)	`GTACAA/CAAAGT`	1	--	ut3¹		11	NA EU EA WA	974
	rs10471830^1,2	A,C,F,H	52426284(+)	`TGTAAC/GCCACT`	1	--	ut3¹		7	EU EA WA NA	560
	rs1109527^1,2	C,F,H,O	52422907(-)	`CCTTAG/TTCTCT`	1	--	ut3¹		24	EA NA EU WA NS MN	1890
	rs7719848^1,2	A,C,F,H	52425212(+)	`AAGGTG/AAGTAT`	1	--	ut3¹		16	EA NA EU WA	1470
	rs1109526^1,2	C,F,H,O	52423080(-)	`TTTCAA/GAAATT`	1	--	ut3¹ ese³		16	EU EA WA NS MN NA	2726
	rs6880055^1,2	C,F,H	52425185(+)	`GCAGTA/GTTTCT`	1	--	ut3¹		4	EU EA WA	416
--	rs7737412^1,2	C,F,H	52425350(+)	`AAATGG/ATGTAC`	1	--	ut3¹		4	EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for ITGA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 192974

10/62 Novoseek disease relationships for ITGA2 gene (see all 62 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
collagen fibril	40.39	1	16854461 (1)
arterial thrombosis	40.17	1	9701455 (1)
glanzmann thrombasthenia	37.05	1	10097812 (1)
metastasis	32.68	18	7681030 (2), 2011740 (1), 9306710 (1), 14735469 (1) (see all 11)
thrombosis	28.57	3	17164499 (1), 18045662 (1), 12617110 (1)
bernard-soulier syndrome	27.48	1	10097812 (1)
osteosarcoma	26.88	3	8326445 (1), 9716443 (1)
rhabdomyosarcoma	23.32	6	2011740 (2), 9306710 (1), 8674074 (1), 7630001 (1)
colon carcinoma	20.54	4	18098323 (1), 11169447 (1), 2304917 (1)
gingival overgrowth	17.35	1	16304451 (1)

About this table

Genatlas disease: ITGA2

neonatal alloimmune thrombocytopenia

Human Gene Mutation Database: ITGA2
Genetic Association Database: ITGA2
Human Genome Epidemiology Navigator: ITGA2 (93 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/654 PubMed articles for ITGA2 gene (see all 654 ):

Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk. (PubMed id 16317580)^{1, 3, 6} Langsenlehner U....Krippl P. (2006)
Association of the gene polymorphisms of platelet glycoprotein Ia and IIb/IIIa with myocardial infarction and extent of coronary artery disease in the Korean population. (PubMed id 15227729)^{1, 3, 6} Park S....Jang Y. (2004)
Platelet glycoprotein I(b)alpha and integrin alpha2 beta1 polymorphisms: gene frequencies and linkage disequilibrium in a population diversity panel. (PubMed id 15978109)^{1, 3, 6} Di Paola J....Murray J.C. (2005)
Glycoprotein Ia 807TT/873AA genotype is not associated with myocardial infarction. (PubMed id 16140647)^{1, 3, 6} Komurcu E....Erginel-Unaltuna N. (2005)
Alpha 2 integrin +807 polymorphism in drug-induced gingival overgrowth. (PubMed id 16304451)^{1, 3, 6} Ogino M....Kataoka M. (2005)
Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis. (PubMed id 12540964)^{1, 3, 6} Reiner A.P....Agardh C.D. (2003)
Association of the GPIa C807T and GPIIIa PlA1/A2 polymorphisms with premature myocardial infarction in men. (PubMed id 11812069)^{1, 3, 6} Benze G....Junker R. (2002)
Role of 4 platelet membrane glycoprotein polymorphisms on experimental arterial thrombus formation in men. (PubMed id 11698306)^{1, 3, 6} Cadroy Y....Sie P. (2001)
The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2). (PubMed id 7901236)^{1, 3, 4} Santoso S....Newman P.J. (1993)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{3, 4} Lewandrowski U.... Sickmann A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3673	HGNC: 6137	AceView: ITGA2	Ensembl:ENSG00000164171	euGenes: HUgn3673
ECgene: ITGA2	H-InvDB: ITGA2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ITGA2	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=ITGA2
SeattleSNPs	http://pga.gs.washington.edu/data/itga2/

Licensable Technologies for ITGA2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ITGA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ITGA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ITGA2		Antibodies for ITGA2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ITGA2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (ITGA2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Integrin alpha 2, Integrin alpha 2+beta 1)
	Antibodies (Integrin alpha 2, Integrin alpha 2+beta 1)

Search OriGene for ITGA2

Search Tocris compounds for ITGA2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ITGA2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ITGA2 Gene at Home site.
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ITGA2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ITGA2

Summaries
for ITGA2

Genomic Location
for ITGA2

Proteins
for ITGA2

Protein Domains/
Families
for ITGA2

Gene Function
for ITGA2

Pathways & Interactions
for ITGA2

Drugs & Compounds
for ITGA2

Transcripts
for ITGA2

Expression
for ITGA2

Orthologs
for ITGA2

Paralogs
for ITGA2

SNPs/Variants
for ITGA2

Disorders & Mutations
for ITGA2

Medical News
for ITGA2

Publications
for ITGA2

Search for ITGA2

Genome Databases showing ITGA2

Other Databases showing ITGA2

Specialized Databases showing ITGA2

Licensable Technologies
for ITGA2

Services
for ITGA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ITGA2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ITGA2

Summariesfor ITGA2

Genomic Locationfor ITGA2

Proteinsfor ITGA2

Protein Domains/Familiesfor ITGA2

Gene Functionfor ITGA2

Pathways & Interactionsfor ITGA2

Drugs & Compoundsfor ITGA2

Transcriptsfor ITGA2

Expression for ITGA2

Orthologsfor ITGA2

Paralogsfor ITGA2

SNPs/Variantsfor ITGA2

Disorders & Mutationsfor ITGA2

Medical Newsfor ITGA2

Publicationsfor ITGA2

Search for ITGA2

Genome Databases showing ITGA2

Other Databases showing ITGA2

Specialized Databases showing ITGA2

Licensable Technologiesfor ITGA2

Servicesfor ITGA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ITGA2

Summaries
for ITGA2

Genomic Location
for ITGA2

Proteins
for ITGA2

Protein Domains/
Families
for ITGA2

Gene Function
for ITGA2

Pathways & Interactions
for ITGA2

Drugs & Compounds
for ITGA2

Transcripts
for ITGA2

Expression
for ITGA2

Orthologs
for ITGA2

Paralogs
for ITGA2

SNPs/Variants
for ITGA2

Disorders & Mutations
for ITGA2

Medical News
for ITGA2

Publications
for ITGA2

Licensable Technologies
for ITGA2

Services
for ITGA2