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Aliases for ITGA11 Gene

Aliases for ITGA11 Gene

  • Integrin Subunit Alpha 11 2 3 5
  • Integrin, Alpha 11 2 3
  • Integrin Alpha 11 3
  • HsT18964 3

External Ids for ITGA11 Gene

Previous GeneCards Identifiers for ITGA11 Gene

  • GC15M064434
  • GC15M061692
  • GC15M066172
  • GC15M066309
  • GC15M066381
  • GC15M068594
  • GC15M045424

Summaries for ITGA11 Gene

Entrez Gene Summary for ITGA11 Gene

  • This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA11 Gene

ITGA11 (Integrin Subunit Alpha 11) is a Protein Coding gene. Diseases associated with ITGA11 include tick infestation and parasitic ectoparasitic infectious disease. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Degradation of the extracellular matrix. GO annotations related to this gene include collagen binding and collagen receptor activity. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA11 Gene

  • Integrin alpha-11/beta-1 is a receptor for collagen.

Gene Wiki entry for ITGA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA11 Gene

Genomics for ITGA11 Gene

Regulatory Elements for ITGA11 Gene

Promoters for ITGA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITGA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITGA11 Gene

Chromosome:
15
Start:
68,296,533 bp from pter
End:
68,432,162 bp from pter
Size:
135,630 bases
Orientation:
Minus strand

Genomic View for ITGA11 Gene

Genes around ITGA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITGA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITGA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA11 Gene

Proteins for ITGA11 Gene

  • Protein details for ITGA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKX5-ITA11_HUMAN
    Recommended name:
    Integrin alpha-11
    Protein Accession:
    Q9UKX5
    Secondary Accessions:
    • J3KQM2
    • Q8WYI8
    • Q9UKQ1

    Protein attributes for ITGA11 Gene

    Size:
    1188 amino acids
    Molecular mass:
    133470 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21.
    SequenceCaution:
    • Sequence=AAL39001.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ITGA11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA11 Gene

Proteomics data for ITGA11 Gene at MOPED

Post-translational modifications for ITGA11 Gene

  • Glycosylation at Asn 82, Asn 95, Asn 291, Asn 331, Asn 358, Asn 449, Asn 462, Asn 528, Asn 642, Asn 694, Asn 857, Asn 894, Asn 973, Asn 1031, Asn 1039, and Asn 1059
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ITGA11 (Integrin alpha 11)

No data available for DME Specific Peptides for ITGA11 Gene

Domains & Families for ITGA11 Gene

Gene Families for ITGA11 Gene

Suggested Antigen Peptide Sequences for ITGA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKX5

UniProtKB/Swiss-Prot:

ITA11_HUMAN :
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Belongs to the integrin alpha chain family.
  • Contains 7 FG-GAP repeats.
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA11: view

Function for ITGA11 Gene

Molecular function for ITGA11 Gene

GENATLAS Biochemistry:
integrin,alpha11,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,predominantly expressed in musculoskeletal tissues,uterus,heart,likely dimerizing with ITGB1
UniProtKB/Swiss-Prot Function:
Integrin alpha-11/beta-1 is a receptor for collagen.

Gene Ontology (GO) - Molecular Function for ITGA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding IMP 11518510
genes like me logo Genes that share ontologies with ITGA11: view
genes like me logo Genes that share phenotypes with ITGA11: view

Animal Models for ITGA11 Gene

MGI Knock Outs for ITGA11:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ITGA11 Gene

Localization for ITGA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA11 Gene COMPARTMENTS Subcellular localization image for ITGA11 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ITGA11 Gene

Pathways & Interactions for ITGA11 Gene

genes like me logo Genes that share pathways with ITGA11: view

Gene Ontology (GO) - Biological Process for ITGA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IDA 16210410
GO:0006929 substrate-dependent cell migration IMP 11518510
GO:0007160 cell-matrix adhesion IMP 11518510
GO:0007229 integrin-mediated signaling pathway IMP 24823363
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ITGA11: view

No data available for SIGNOR curated interactions for ITGA11 Gene

Drugs & Compounds for ITGA11 Gene

No Compound Related Data Available

Transcripts for ITGA11 Gene

Unigene Clusters for ITGA11 Gene

Integrin, alpha 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^
SP1: - - -
SP2:
SP3: -
SP4:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ITGA11 Gene

GeneLoc Exon Structure for
ITGA11
ECgene alternative splicing isoforms for
ITGA11

Expression for ITGA11 Gene

mRNA expression in normal human tissues for ITGA11 Gene

mRNA differential expression in normal tissues according to GTEx for ITGA11 Gene

This gene is overexpressed in Artery - Aorta (x16.1), Uterus (x5.7), and Artery - Coronary (x5.2).

Protein differential expression in normal tissues from HIPED for ITGA11 Gene

This gene is overexpressed in Uterus (26.2), Bone marrow mesenchymal stem cell (22.1), and Cervix (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA11 Gene



SOURCE GeneReport for Unigene cluster for ITGA11 Gene Hs.436416

mRNA Expression by UniProt/SwissProt for ITGA11 Gene

Q9UKX5-ITA11_HUMAN
Tissue specificity: According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver.
genes like me logo Genes that share expression patterns with ITGA11: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ITGA11 Gene

Orthologs for ITGA11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA11 35
  • 98.99 (n)
  • 98.99 (a)
ITGA11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA11 36
  • 93 (a)
OneToOne
ITGA11 35
  • 90.32 (n)
  • 92.59 (a)
dog
(Canis familiaris)
Mammalia ITGA11 35
  • 89.68 (n)
  • 92.13 (a)
ITGA11 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga11 16
Itga11 35
  • 86.78 (n)
  • 90.24 (a)
Itga11 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA11 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA11 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga11 35
  • 86.54 (n)
  • 89.6 (a)
chicken
(Gallus gallus)
Aves ITGA11 35
  • 76.23 (n)
  • 78.28 (a)
ITGA11 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA11 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itga11 35
  • 69.16 (n)
  • 71.85 (a)
zebrafish
(Danio rerio)
Actinopterygii itga11a 36
  • 57 (a)
OneToMany
itga11b 36
  • 54 (a)
OneToMany
itga11a 35
  • 62.78 (n)
  • 59.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for ITGA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA11 Gene

ENSEMBL:
Gene Tree for ITGA11 (if available)
TreeFam:
Gene Tree for ITGA11 (if available)

Paralogs for ITGA11 Gene

(4) SIMAP similar genes for ITGA11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITGA11: view

Variants for ITGA11 Gene

Sequence variations from dbSNP and Humsavar for ITGA11 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs895136 -- 68,431,108(-) GCGGC(C/T)GCCAG intron-variant
rs895137 -- 68,430,914(-) ACCCC(C/T)ATCCC intron-variant
rs898578 -- 68,413,615(+) CCCCG(A/G)TGCCT intron-variant
rs898580 -- 68,343,588(-) CTCCA(C/T)CGTCT intron-variant
rs898583 -- 68,343,110(-) CCAAG(C/T)GCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA11 Gene

Variant ID Type Subtype PubMed ID
dgv752e1 CNV Complex 17122850
esv33024 CNV Gain 17666407
esv999038 CNV Deletion 20482838
nsv471248 CNV Gain 18288195
nsv9273 CNV Loss 18304495
nsv1582 CNV Insertion 18451855
esv1007510 CNV Insertion 20482838
esv1045367 CNV Insertion 17803354
esv1196404 CNV Deletion 17803354
esv1977419 CNV Deletion 18987734
esv5360 CNV Deletion 18987735
esv8981 CNV Loss 19470904
esv2749816 CNV Deletion 23290073

Variation tolerance for ITGA11 Gene

Residual Variation Intolerance Score: 74.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.33; 88.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITGA11 Gene

HapMap Linkage Disequilibrium report
ITGA11
Human Gene Mutation Database (HGMD)
ITGA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA11 Gene

Disorders for ITGA11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ITGA11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
tick infestation
  • tick infestations
parasitic ectoparasitic infectious disease
  • ectoparasitism
cardiomyopathy
  • cardiomyopathies
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ITGA11

Genetic Association Database (GAD)
ITGA11
Human Genome Epidemiology (HuGE) Navigator
ITGA11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITGA11
genes like me logo Genes that share disorders with ITGA11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITGA11 Gene

Publications for ITGA11 Gene

  1. Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11). (PMID: 10486209) Lehnert K. … Krissansen G.W. (Genomics 1999) 2 3 4 23 67
  2. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. (PMID: 17600088) Zhu C.Q. … Tsao M.S. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 23
  3. Analysis of the human integrin alpha11 gene (ITGA11) and its promoter. (PMID: 12392762) Zhang W.M. … Gullberg D. (Matrix Biol. 2002) 3 23
  4. Collagen-binding I+11 integrin expression in human myometrium and fibroids utilizing a novel RNA in situ probe. (PMID: 24520080) Peavey M. … Leppert P. (Reprod Sci 2014) 3
  5. Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner. (PMID: 24823363) SipilAo K. … Heino J. (FASEB J. 2014) 3

Products for ITGA11 Gene

Sources for ITGA11 Gene

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