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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGA11 Gene

protein-coding GIFtS: 65
GCID: GC15M068594

integrin, alpha 11

Explore 7 diseases affiliated with
ITGA11 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha 11¹ ²
HsT18964¹ ²
Integrin Alpha-11²

External Ids:	HGNC: 6136¹	Entrez Gene: 22801²	Ensembl: ENSG00000137809⁷	OMIM: 604789⁵	UniProtKB: Q9UKX5³

Export aliases for ITGA11 gene to outside databases

Previous GC identifers: GC15M064434 GC15M061692 GC15M066172 GC15M066309 GC15M066381 GC15M045424

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA11:

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain

and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in

vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to

the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their

biological validity is not determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5

Function: Integrin alpha-11/beta-1 is a receptor for collagen

Gene Wiki entry for ITGA11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGA11 gene promoter:
GR NF-1 NF-1/L C/EBPalpha YY1 GATA-1 Pax-3 E2F-1 E2F GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGA11 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGA11

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23 Ensembl cytogenetic band: 15q23 HGNC cytogenetic band: 15q22.3-q23

ITGA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA11 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M068594: view genomic region (about GC identifiers)

Start:	68,594,042 bp from pter	End:	68,724,501 bp from pter
Size:	130,460 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5 (See protein sequence)

Recommended Name: Integrin alpha-11 precursor

Size: 1188 amino acids; 133470 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21

Subcellular location: Membrane; Single-pass type I membrane protein

Developmental stage: Strongly up-regulated in differentiating fetal muscle cells (in vitro)

Sequence caution: Sequence=AAL39001.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: Q8WYI8 Q9UKQ1

Explore the universe of human proteins at neXtProt for ITGA11: NX_Q9UKX5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UKX5

ITGA11 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004439.1

ENSEMBL proteins:

ENSP00000403392 ENSP00000327290

Reactome Protein details: Q9UKX5
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--

ITGA11 for ontologies About GeneDecksing

ITGA11 Antibody Products:

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	Browse Antibodies at Uscn
	ThermoFisher Antibodies for ITGA11

Assay Products for ITGA11:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ITGA11
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGA11 for domains About GeneDecksing

5 InterPro domains/families:

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR013517 FG-GAP

IPR013649 Integrin_alpha-2

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry Q9UKX5

ProtoNet protein and cluster: Q9UKX5

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5

Function: Integrin alpha-11/beta-1 is a receptor for collagen

Genatlas biochemistry entry for ITGA11:

integrin,alpha11,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other

cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within

cells,predominantly expressed in musculoskeletal tissues,uterus,heart,likely dimerizing with ITGB1

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		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA11 (see all 39):
		hsa-let-7d hsa-miR-29a hsa-miR-486-3p hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-532-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ITGA11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGA11

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGA11
		Search LifeMap BioReagents cell lines for ITGA11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA11

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005518	collagen binding	TAS	10464311
GO:0046872	metal ion binding	IEA	--

ITGA11 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Itga11^tm1Dgul for ITGA11
     6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Itga11):

behavior/neurological	cellular	craniofacial	growth/size	mortality/aging
skeleton

ITGA11 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Integrin outside-in signaling	0.37
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Integrin outside-in signaling	0.37

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ITGA11

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Integrin outside-in signaling

5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA11 (see all 33)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

2 Tocris Bioscience Pathways for ITGA11

	NF-kappaB Pathway
	MAPK Pathway

2 GeneGo (Thomson Reuters) Pathways for ITGA11

	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Integrin-mediated cell adhesion and migration

3 BioSystems Pathways for ITGA11

	Integrin-mediated cell adhesion
	Focal Adhesion
	Arrhythmogenic right ventricular cardiomyopathy

2 Reactome Pathways for ITGA11

	Integrin cell surface interactions
	Signal Transduction

5/6 Kegg Pathways (Kegg details for ITGA11) (see all 6):

	Focal adhesion
	ECM-receptor interaction
	Regulation of actin cytoskeleton
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

ITGA11 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ITGA11

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/94 Interacting proteins for ITGA11 (Q9UKX5³ ENSP00000327290⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 94)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB1	P05556³, ENSP00000364094⁴	I2D: score=2 STRING: ENSP00000364094
COL1A1	ENSP00000225964⁴	STRING: ENSP00000225964
COL1A2	ENSP00000297268⁴	STRING: ENSP00000297268
ACTB	ENSP00000349960⁴	STRING: ENSP00000349960
ACTG1	ENSP00000331514⁴	STRING: ENSP00000331514

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	10486209
GO:0007160	cell-matrix adhesion	TAS	10464311
GO:0007229	integrin-mediated signaling pathway	IEA	--
GO:0007517	muscle organ development	TAS	10464311

ITGA11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGA11
Search CenterWatch for drugs/clinical trials and news about ITGA11 / ITA11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGA11 gene (2 alternative transcripts):

NM_001004439.1 NM_012211.3

Unigene Cluster for ITGA11:

Integrin, alpha 11

Hs.436416 [show with all ESTs]

Unigene Representative Sequence: NM_001004439

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000423218(uc010bib.3) ENST00000569346 ENST00000566429 ENST00000562826

ENST00000565868 ENST00000568677 ENST00000315757(uc002ari.3)

miRNA Products:		OriGene 3'-UTR Clone: ITGA11 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA11
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA11 (see all 39):
		hsa-let-7d hsa-miR-29a hsa-miR-486-3p hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-532-5p

		SwitchGear 3'UTR luciferase reporter plasmid: ITGA11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA11 (see all 7) OriGene shRNA RFP: ITGA11 OriGene siRNA: ITGA11
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Additional cDNA sequence:

AF111799.1 AF137378.2 AK095863.1 AK292445.1 AK304778.1 AL359064.1 Z50157.1 Z50167.1

6 DOTS entries:

DT.307247 DT.100776426 DT.121037534 DT.121037597 DT.91748537 DT.100776425

24/74 AceView cDNA sequences (see all 74):

NM_012211 AL359064 AW068275 W45174 BX496541 CB158653 AF111799 NM_001004439

BQ003687 AW069755 BU630187 CA414176 AW851445 CF264714 BX476418 BQ575358

BF056654 BU163814 CA412082 BG939168 BF509527 AF109681 AK095863 BX505719

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA11 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b	^	16	^	17	^	18	^	19a	·	19b	·	19c	^	20	^	21	^
SP1:									-														-																								-
SP2:
SP3:																											-
SP4:

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for ITGA11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGA11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGCCAGTG

About this image

ITGA11 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12)

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ITGA11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGA11

SOURCE GeneReport for Unigene cluster: Hs.436416

UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5

Tissue specificity: According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels

in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also

found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands and prostate. Very low

levels in peripheral blood lymphocytes, fetal brain and fetal liver

SABiosciences Expression via Pathway-Focused PCR Array including ITGA11:

Focal Adhesions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGA11 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ITGA11¹	integrin, alpha 11	76.21(n) 78.2(a)		415560 XM_413930.3 XP_413930.2
lizard (Anolis carolinensis)	Reptilia	ITGA10⁶ --	--	87(a) 20(a)	1 ↔ 1 possible ortholog	AAWZ02038485(143-9213) GL343516.1(252432-271527)
African clawed frog (Xenopus laevis)	Amphibia	U44025.1²	--	73.81(n)		U44025.1
zebrafish (Danio rerio)	Actinopterygii	itga11a¹	integrin, alpha 11a	62.75(n) 59.71(a)		541475 NM_001172627.1 NP_001166098.1
fruit fly (Drosophila melanogaster)	Insecta	alphaPS5⁶ scb⁶ (see all 3)	scab (see all 3)	19(a) 18(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(19444333-19447720) 2R(11136290-11146003)

ENSEMBL Gene Tree for ITGA11 (if available)
TreeFam Gene Tree for ITGA11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGA11 gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA2² ITGA5²

ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGAL² ITGA9² ITGA4²

ITGA10²

4 SIMAP similar genes for ITGA11 using alignment to 2 protein entries: ITA11_HUMAN (see all proteins):

ITGA2 ITGA10 COL21A1 ITGA1

ITGA11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115132698^1,2		--	68593546(+)	`TGTGGA/GAGCCT`	1	--	ds500¹		0	--	--	--	--
rs186500524^1,2		--	68593693(+)	`TAAGAC/TGGTTA`	1	--	ds500¹		0	--	--	--	--
rs141677236^1,2		--	68593732(+)	`GAGGCA/GTGAGA`	1	--	ds500¹		0	--	--	--	--
rs193116618^1,2		--	68593791(+)	`CTAACC/TGTCCA`	1	--	ds500¹		0	--	--	--	--
rs7176148^1,2	C,F,H,	--	68593797(+)	`GTCCAC/AACTGG`	1	--	ds500¹		11		NS EA NA WA	1312
rs185581845^1,2		--	68593861(+)	`CACACA/GGAGGC`	1	--	ds500¹		0	--	--	--	--
rs188500103^1,2		--	68593870(+)	`GCCAGA/GCAGCC`	1	--	ds500¹		0	--	--	--	--
rs145957262^1,2		--	68593988(+)	`AAGGGC/GAGTAT`	1	--	ds500¹		0	--	--	--	--
rs193082863^1,2		--	68594298(+)	`TTGCAC/TGTGCT`	1	--	ut3¹		0	--	--	--	--
rs138965769^1,2		--	68594353(+)	`AGCCCC/TTCCCT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ITGA11 (68594042 - 68724501 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for ITGA11
4 CNVs: 35332 7068 3965 23500
5 Indels: 61457 41753 33604 45359 40107
Human Gene Mutation Database (HGMD): ITGA11

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ITGA11 for disorders           About GeneDecksing

OMIM gene information: 604789    OMIM disorders: --

7 diseases for ITGA11:    About MalaCards

tick infestation adhd lung cancer lung adenocarcinoma

adenocarcinoma thyroiditis prostatitis

1 disease from the University of Copenhagen DISEASES database for ITGA11:

Tick infestation

1 Novoseek disease relationship for ITGA11 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nsclc	50.5	3	17016581 (2)

Human Genome Epidemiology (HuGE) Navigator: ITGA11 (4 documents)

Export disorders for ITGA11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ITGA11 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with ITGA11)

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Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11). (PubMed id 10486209)^{1, 2, 3, 9} Lehnert K.... Krissansen G.W. (1999)
cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues. (PubMed id 10464311)^{1, 2} Velling T.... Gullberg D. (1999)
Analysis of the human integrin alpha11 gene (ITGA11) and its promoter. (PubMed id 12392762)^{1, 9} Zhang W.M....Gullberg D. (2002)
Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. (PubMed id 17600088)^{1, 9} Zhu C.Q....Tsao M.S. (2007)
Integrins I+2I^1 and I+11I^1 regulate the survival of mes enchymal stem cells on collagen I. (PubMed id 21796158)¹ Popov C....Docheva D. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The human alpha11 integrin promoter drives fibroblast -restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1 -dependent manner. (PubMed id 19913614)¹ Lu N....Gullberg D. (2010)
A role for alpha11beta1 integrin in the human periodo ntal ligament. (PubMed id 19641149)¹ Barczyk M.M....Bolstad A.I. (2009)
Lung cancer susceptibility model based on age, family history and genetic variants. (PubMed id 19390575)¹ Young R.P....Gamble G.D. (2009)
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 22801	HGNC: 6136	AceView: ITGA11	Ensembl:ENSG00000137809	euGenes: HUgn22801
ECgene: ITGA11	Kegg: 22801	H-InvDB: ITGA11

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGA11	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGA11	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGA11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ITGA11 gene:
Search GeneIP for patents involving ITGA11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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