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ITGA11 Gene

protein-coding   GIFtS: 67
GCID: GC15M068594

Integrin, Alpha 11

  See ITGA11-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 111 2
HsT189642
Integrin Alpha-112

External Ids:    HGNC: 61361   Entrez Gene: 228012   Ensembl: ENSG000001378097   OMIM: 6047895   UniProtKB: Q9UKX53   

Export aliases for ITGA11 gene to outside databases

Previous GC identifers: GC15M064434 GC15M061692 GC15M066172 GC15M066309 GC15M066381 GC15M045424


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA11 Gene:
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha
chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1
integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching
muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this
gene, but their biological validity is not determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA11 Gene:
ITGA11 (integrin, alpha 11) is a protein-coding gene. Diseases associated with ITGA11 include tick infestation. GO annotations related to this gene include collagen binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5
Function: Integrin alpha-11/beta-1 is a receptor for collagen

Gene Wiki entry for ITGA11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA11 gene promoter:
         GR   NF-1   NF-1/L   C/EBPalpha   YY1   GATA-1   Pax-3   E2F-1   E2F   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA11 promoter sequence
   Search Chromatin IP Primers for ITGA11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q23   HGNC cytogenetic band: 15q22.3-q23

ITGA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA11 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M068594:  view genomic region     (about GC identifiers)

Start:
68,594,042 bp from pter      End:
68,724,501 bp from pter
Size:
130,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5 (See protein sequence)
Recommended Name: Integrin alpha-11 precursor  
Size: 1188 amino acids; 133470 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21
Developmental stage: Strongly up-regulated in differentiating fetal muscle cells (in vitro)
Sequence caution: Sequence=AAL39001.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: J3KQM2 Q8WYI8 Q9UKQ1
Alternative splicing: 2 isoforms:  Q9UKX5-1   Q9UKX5-2   

Explore the universe of human proteins at neXtProt for ITGA11: NX_Q9UKX5

Explore proteomics data for ITGA11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn82, Asn95, Asn291, Asn331, Asn358, Asn449, Asn462, Asn528, Asn642, Asn694,
                                 Asn857, Asn894, Asn973, Asn1031, Asn1039, Asn1059
  • Modification sites at PhosphoSitePlus

  • See ITGA11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001004439.1  
    ENSEMBL proteins: 
     ENSP00000403392   ENSP00000327290  
    Reactome Protein details: Q9UKX5

    ITGA11 Human Recombinant Protein Products:

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    Novus Biologicals ITGA11 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA11 

    ITGA11 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA11
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for ITGA11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    5 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry Q9UKX5

    ProtoNet protein and cluster: Q9UKX5

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGA11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA11_HUMAN, Q9UKX5
    Function: Integrin alpha-11/beta-1 is a receptor for collagen

         Genatlas biochemistry entry for ITGA11:
    integrin,alpha11,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,predominantly expressed in musculoskeletal tissues,uterus,heart,likely dimerizing with ITGB1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005518collagen binding TAS10464311
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGA11           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itga11):
     behavior/neurological  cellular  craniofacial  growth/size/body  mortality/aging 
     skeleton 

    Find genes that share phenotypes with ITGA11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itga11tm1Dgul for ITGA11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA11

    miRNA
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    miRTarBase miRNAs that target ITGA11:
    hsa-mir-29a-3p (MIRT005675)

    Block miRNA regulation of human, mouse, rat ITGA11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA11 (see all 39):
    hsa-let-7d hsa-miR-29a hsa-miR-486-3p hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidITGA11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ITGA11

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ITGA11 (NM_001004439)
    Sino Biological Human cDNA Clone for ITGA11
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA11_HUMAN, Q9UKX5: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--

    Find genes that share ontologies with ITGA11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA11 About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5ERK Signaling
    Rho Family GTPases0.61
    MAPK Signaling0.58
    ERK Signaling0.61
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with ITGA11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA11 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    2 Tocris Bioscience Pathways for ITGA11
        NF-kappaB Pathway
    MAPK Pathway

    2 GeneGo (Thomson Reuters) Pathways for ITGA11
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration

    3 BioSystems Pathways for ITGA11
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    1 Reactome Pathway for ITGA11
        Integrin cell surface interactions


    Selected Kegg Pathways  (Kegg details for ITGA11) (see all 7):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Regulation of actin cytoskeleton
    Hypertrophic cardiomyopathy (HCM)

        Pathway & Disease-focused RT2 Profiler PCR Array including ITGA11: 
              Focal Adhesions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ITGA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA11 (Q9UKX53 ENSP000003272904) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055563, ENSP000003640944I2D: score=2 STRING: ENSP00000364094
    COL1A1ENSP000002259644STRING: ENSP00000225964
    COL1A2ENSP000002972684STRING: ENSP00000297268
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS10486209
    GO:0007160cell-matrix adhesion TAS10464311
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007517muscle organ development TAS10464311
    GO:0030198extracellular matrix organization TAS--

    Find genes that share ontologies with ITGA11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGA11 (ITA11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGA11 gene (2 alternative transcripts): 
    NM_001004439.1  NM_012211.3  

    Unigene Cluster for ITGA11:

    Integrin, alpha 11
    Hs.436416  [show with all ESTs]
    Unigene Representative Sequence: NM_001004439
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000423218(uc010bib.3) ENST00000569346 ENST00000566429 ENST00000562826
    ENST00000565868 ENST00000568677 ENST00000315757(uc002ari.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ITGA11 (see all 39):
    hsa-let-7d hsa-miR-29a hsa-miR-486-3p hsa-miR-301a hsa-miR-519a hsa-let-7g hsa-let-7a hsa-miR-532-5p
    SwitchGear 3'UTR luciferase reporter plasmidITGA11 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ITGA11
      QuantiFast Probe-based Assays in human, mouse, rat ITGA11

    Additional mRNA sequence: 

    AF111799.1 AF137378.2 AK095863.1 AK292445.1 AK304778.1 AL359064.1 Z50157.1 Z50167.1 

    6 DOTS entries:

    DT.307247  DT.100776426  DT.121037534  DT.121037597  DT.91748537  DT.100776425 

    Selected AceView cDNA sequences (see all 74):

    NM_012211 AL359064 AW069755 CB158653 W45174 CA414176 BU630187 AF111799 
    BX496541 AW068275 NM_001004439 BQ003687 CF264714 CA412082 BU163814 CF272349 
    BI755109 BX119665 AF137378 AK095863 BG939168 AW851445 BF965934 BF509527 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA11    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^
    SP1:                          -                                         -                                                                       -               
    SP2:                                                                                                                                                            
    SP3:                                                                                -                                                                           
    SP4:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for ITGA11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCCAGTG
    ITGA11 Expression
    About this image


    ITGA11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Epidermis (Integumentary System)
             Detroit 551
    ITGA11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436416

    UniProtKB/Swiss-Prot: ITA11_HUMAN, Q9UKX5
    Tissue specificity: According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate
    levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to
    PubMed:10486209, also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid
    glands and prostate. Very low levels in peripheral blood lymphocytes, fetal brain and fetal liver

        Pathway & Disease-focused RT2 Profiler PCR Array including ITGA11: 
              Focal Adhesions in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga111 , 5 integrin alpha 111, 5 86.78(n)1
    90.24(a)1
      9 (33.82 cM)5
    3194801  NM_176922.51  NP_795896.41 
     626778265 
    chicken
    (Gallus gallus)
    Aves ITGA111 integrin, alpha 11 76.23(n)
    78.28(a)
      415560  XM_004943923.1  XP_004943980.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA116
    integrin, alpha 11
    87(a)
    1 ↔ 1
    AAWZ02038485(143-9213)
    African clawed frog
    (Xenopus laevis)
    Amphibia U44025.12   -- 73.81(n)    U44025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii itga11a1 integrin, alpha 11a 62.78(n)
    59.71(a)
      541475  NM_001172627.1  NP_001166098.1 


    ENSEMBL Gene Tree for ITGA11 (if available)
    TreeFam Gene Tree for ITGA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA11 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    4 SIMAP similar genes for ITGA11 using alignment to 1 protein entry:     ITA11_HUMAN:
    ITGA2    ITGA10    COL21A1    ITGA1

    Find genes that share paralogs with ITGA11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA11 (see all 3299)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs559332201,2
    C--48687929(+) TCTCT-/CTCTC 
     TCTCTCT
    GAACC
    1 -- int11Minor allele frequency- CTCTCTCTCTCT:0.00NA 2
    rs1151326981,2
    C--68593546(+) TGTGGA/GAGCCT 1 -- ds50010--------
    rs1865005241,2
    --68593693(+) TAAGAC/TGGTTA 1 -- ds50010--------
    rs1416772361,2
    C--68593732(+) GAGGCA/GTGAGA 1 -- ds50010--------
    rs1931166181,2
    --68593791(+) CTAACC/TGTCCA 1 -- ds50010--------
    rs71761481,2
    C,F,H--68593797(+) gtccaC/Aactgg 1 -- ds500111Minor allele frequency- A:0.09NS EA NA WA 1312
    rs1855818451,2
    --68593861(+) CACACA/GGAGGC 1 -- ds50010--------
    rs1885001031,2
    --68593870(+) GCCAGA/GCAGCC 1 -- ds50010--------
    rs1459572621,2
    --68593988(+) AAGGGC/GAGTAT 1 -- ds50010--------
    rs1930828631,2
    --68594298(+) TTGCAC/TGTGCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ITGA11 (68594042 - 68724501 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGA11 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999038CNV Deletion20482838
    esv1196404CNV Deletion17803354
    esv2749816CNV Deletion23290073
    esv5360CNV Deletion18987735
    esv1977419CNV Deletion18987734
    esv1045367CNV Insertion17803354
    nsv1582CNV Insertion18451855
    esv1007510CNV Insertion20482838
    nsv9273CNV Loss18304495
    esv8981CNV Loss19470904

    Human Gene Mutation Database (HGMD): ITGA11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA11
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604789    OMIM disorders: --

    1 disease for ITGA11:    
    About MalaCards
    tick infestation

    1 disease from the University of Copenhagen DISEASES database for ITGA11:
    Tick infestation

    Find genes that share disorders with ITGA11           About GenesLikeMe

    1 Novoseek inferred disease relationship for ITGA11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nsclc 50.5 3 17016581 (2)

    Genetic Association Database (GAD): ITGA11
    Human Genome Epidemiology (HuGE) Navigator: ITGA11 (4 documents)

    Export disorders for ITGA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA11 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with ITGA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11). (PubMed id 10486209)1, 2, 3, 9 Lehnert K.... Krissansen G.W. (Genomics 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Lung cancer susceptibility model based on age, family history and genetic variants. (PubMed id 19390575)1, 4 Young R.P....Gamble G.D. (PLoS ONE 2009)
    4. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    6. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PubMed id 18839057)1, 4 Lesch K.P....Jacob C. (J Neural Transm 2008)
    7. cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues. (PubMed id 10464311)1, 2 Velling T.... Gullberg D. (J. Biol. Chem. 1999)
    8. Analysis of the human integrin alpha11 gene (ITGA11) and its promoter. (PubMed id 12392762)1, 9 Zhang W.M....Gullberg D. (Matrix Biol. 2002)
    9. Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells. (PubMed id 17600088)1, 9 Zhu C.Q....Tsao M.S. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    10. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22801 HGNC: 6136 AceView: ITGA11 Ensembl:ENSG00000137809 euGenes: HUgn22801
    ECgene: ITGA11 Kegg: 22801 H-InvDB: ITGA11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGA11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ITGA11 gene:
    Search GeneIP for patents involving ITGA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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