Aliases for ITGA11 Gene
External Ids for ITGA11 Gene
Previous GeneCards Identifiers for ITGA11 Gene
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ITGA11 Gene
ITGA11 (Integrin Subunit Alpha 11) is a Protein Coding gene. Diseases associated with ITGA11 include Tick Infestation and Parasitic Ectoparasitic Infectious Disease. Among its related pathways are Reelin Pathway (Cajal-Retzius cells) and NFAT and Cardiac Hypertrophy. GO annotations related to this gene include collagen binding and collagen receptor activity. An important paralog of this gene is ITGA10.
UniProtKB/Swiss-Prot for ITGA11 Gene
Integrin alpha-11/beta-1 is a receptor for collagen.