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Aliases for ITGA10 Gene

Aliases for ITGA10 Gene

  • Integrin, Alpha 10 2 3
  • Integrin Alpha-10 3
  • PRO827 3

External Ids for ITGA10 Gene

Summaries for ITGA10 Gene

Entrez Gene Summary for ITGA10 Gene

  • Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for ITGA10 Gene

ITGA10 (Integrin, Alpha 10) is a Protein Coding gene. Diseases associated with ITGA10 include arrhythmogenic right ventricular cardiomyopathy. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include collagen binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA10 Gene

  • Integrin alpha-10/beta-1 is a receptor for collagen

Gene Wiki entry for ITGA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA10 Gene

Genomics for ITGA10 Gene

Genomic Location for ITGA10 Gene

Start:
145,891,208 bp from pter
End:
145,910,371 bp from pter
Size:
19,164 bases
Orientation:
Minus strand

Genomic View for ITGA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA10 Gene

Regulatory Elements for ITGA10 Gene

Proteins for ITGA10 Gene

  • Protein details for ITGA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75578-ITA10_HUMAN
    Recommended name:
    Integrin alpha-10
    Protein Accession:
    O75578
    Secondary Accessions:
    • B2RAM4
    • B2RTV5
    • Q6UXJ6
    • Q9UHZ8

    Protein attributes for ITGA10 Gene

    Size:
    1167 amino acids
    Molecular mass:
    127602 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1

    Alternative splice isoforms for ITGA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITGA10 Gene

Proteomics data for ITGA10 Gene at MOPED

Post-translational modifications for ITGA10 Gene

  • Glycosylation at Asn98, Asn234, Asn336, Asn364, Asn733, Asn763, Asn839, Asn921, Asn1011, Asn1018, and Asn1039

Other Protein References for ITGA10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGA10 Gene

Domains for ITGA10 Gene

Gene Families for ITGA10 Gene

HGNC:
  • ITG :Integrins

UniProtKB/Swiss-Prot:

ITA10_HUMAN
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage:
    • O75578
  • Contains 1 VWFA domain.:
    • O75578
Family:
  • Belongs to the integrin alpha chain family.:
    • O75578
Similarity:
  • Contains 7 FG-GAP repeats.:
    • O75578
genes like me logo Genes that share domains with ITGA10: view

Function for ITGA10 Gene

Molecular function for ITGA10 Gene

UniProtKB/Swiss-Prot Function: Integrin alpha-10/beta-1 is a receptor for collagen

Gene Ontology (GO) - Molecular Function for ITGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding TAS 9685391
GO:0046872 metal ion binding IEA --
GO:0098639 collagen binding involved in cell-matrix adhesion IMP 24823363
genes like me logo Genes that share ontologies with ITGA10: view

Phenotypes for ITGA10 Gene

genes like me logo Genes that share phenotypes with ITGA10: view

Animal Models for ITGA10 Gene

MGI Knock Outs for ITGA10:

miRNA for ITGA10 Gene

miRTarBase miRNAs that target ITGA10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA10 Gene

Localization for ITGA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA10 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA10 Gene COMPARTMENTS Subcellular localization image for ITGA10 gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for ITGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008305 integrin complex TAS 9685391
GO:0034680 integrin alpha10-beta1 complex IDA 24823363
genes like me logo Genes that share ontologies with ITGA10: view

Pathways for ITGA10 Gene

genes like me logo Genes that share pathways with ITGA10: view

Gene Ontology (GO) - Biological Process for ITGA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007160 cell-matrix adhesion IMP 24823363
GO:0007229 integrin-mediated signaling pathway IMP 24823363
GO:0007411 axon guidance TAS --
GO:0007596 blood coagulation TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with ITGA10: view

Transcripts for ITGA10 Gene

Unigene Clusters for ITGA10 Gene

Integrin, alpha 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
SP1: -
SP2:
SP3:
SP4:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
SP1:
SP2:
SP3:
SP4:

Relevant External Links for ITGA10 Gene

GeneLoc Exon Structure for
ITGA10
ECgene alternative splicing isoforms for
ITGA10

Expression for ITGA10 Gene

mRNA expression in normal human tissues for ITGA10 Gene

mRNA differential expression in normal tissues according to GTEx for ITGA10 Gene

This gene is overexpressed in Artery - Aorta (13.5), Artery - Coronary (7.2), and Artery - Tibial (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ITGA10 Gene

SOURCE GeneReport for Unigene cluster for ITGA10 Gene Hs.158237

mRNA Expression by UniProt/SwissProt for ITGA10 Gene

O75578-ITA10_HUMAN
Tissue specificity: Widely expressed with highest expression in muscle and heart. Found in articular cartilage
genes like me logo Genes that share expressions with ITGA10: view

Orthologs for ITGA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA10 36
  • 99.51 (n)
  • 99.49 (a)
ITGA10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA10 36
  • 90.03 (n)
  • 91.43 (a)
ITGA10 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA10 36
  • 89.79 (n)
  • 92.45 (a)
ITGA10 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga10 36
  • 86.55 (n)
  • 88.09 (a)
Itga10 16
Itga10 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA10 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 25 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Itga10 36
  • 86.61 (n)
  • 87.83 (a)
lizard
(Anolis carolinensis)
Reptilia ITGA10 37
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii itga10 36
  • 59.08 (n)
  • 54.97 (a)
itga10 37
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToMany
Species with no ortholog for ITGA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA10 Gene

ENSEMBL:
Gene Tree for ITGA10 (if available)
TreeFam:
Gene Tree for ITGA10 (if available)

Paralogs for ITGA10 Gene

Selected SIMAP similar genes for ITGA10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ITGA10: view

Variants for ITGA10 Gene

Sequence variations from dbSNP and Humsavar for ITGA10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1109216 -- 145,896,412(+) GGGCA(A/C/G/T)ATGAT intron-variant
rs1328584 -- 145,902,527(+) TTGAA(A/G)AAGAA reference, synonymous-codon, nc-transcript-variant
rs2274613 -- 145,893,349(+) AAAGC(A/C/G/T)AGCCC intron-variant
rs2274614 -- 145,896,608(+) GCTTA(A/T)AAGGG intron-variant
rs2274615 -- 145,896,937(+) TCAAT(A/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA10 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
dgv105e1 CNV Complex 17122850
esv2422428 CNV Duplication 17116639
dgv347n71 CNV Gain 21882294
nsv831370 CNV Gain 17160897
nsv831381 CNV Gain 17160897
nsv2710 CNV Insertion 18451855
nsv872232 CNV Gain 21882294

Relevant External Links for ITGA10 Gene

HapMap Linkage Disequilibrium report
ITGA10

Disorders for ITGA10 Gene

genes like me logo Genes that share disorders with ITGA10: view

No data available for UniProtKB/Swiss-Prot for ITGA10 Gene

Publications for ITGA10 Gene

  1. The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization. (PMID: 10702680) Lehnert K. … Krissansen G.W. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes. (PMID: 9685391) Camper L. … Lundgren-Aakerlund E. (J. Biol. Chem. 1998) 2 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The fibril-associated collagen IX provides a novel mechanism for cell adhesion to cartilaginous matrix. (PMID: 15383545) KAopylAo J. … Heino J. (J. Biol. Chem. 2004) 3
  5. Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. (PMID: 16684505) Wenke A.K. … Bosserhoff A.K. (Biochem. Biophys. Res. Commun. 2006) 3

Products for ITGA10 Gene

Sources for ITGA10 Gene

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