External Ids for ITGA10 Gene
Previous GeneCards Identifiers for ITGA10 Gene
Integrins are integral transmembrane glycoproteins composed of noncovalently linked alpha and beta chains. They participate in cell adhesion as well as cell-surface mediated signalling. This gene encodes an integrin alpha chain and is expressed at high levels in chondrocytes, where it is transcriptionally regulated by AP-2epsilon and Ets-1. The protein encoded by this gene binds to collagen. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
GeneCards Summary for ITGA10 Gene
ITGA10 (Integrin, Alpha 10) is a Protein Coding gene. Diseases associated with ITGA10 include arrhythmogenic right ventricular cardiomyopathy. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include collagen binding. An important paralog of this gene is ITGA8.
UniProtKB/Swiss-Prot for ITGA10 Gene
Integrin alpha-10/beta-1 is a receptor for collagen