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ITGA10 Gene

protein-coding   GIFtS: 59
GCID: GC01P145524

Integrin, Alpha 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 101 2
PRO8272
Integrin Alpha-102

External Ids:    HGNC: 61351   Entrez Gene: 85152   Ensembl: ENSG000001431277   OMIM: 6040425   UniProtKB: O755783   

Export aliases for ITGA10 gene to outside databases

Previous GC identifers: GC01P144045 GC01P142112 GC01P143252 GC01P143273 GC01P143014 GC01P144236 GC01P119488


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA10 Gene:
Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate
in cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the
integrin beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ITGA10 Gene:
ITGA10 (integrin, alpha 10) is a protein-coding gene. GO annotations related to this gene include collagen binding. An important paralog of this gene is ITGA1.

UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578
Function: Integrin alpha-10/beta-1 is a receptor for collagen

Gene Wiki entry for ITGA10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA10 gene promoter:
         USF1   RP58   AML1a   POU3F1   HTF   Egr-2   NRF-2   Sox9   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA10 promoter sequence
   Search Chromatin IP Primers for ITGA10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

ITGA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P145524:  view genomic region     (about GC identifiers)

Start:
145,524,891 bp from pter      End:
145,543,868 bp from pter
Size:
18,978 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578 (See protein sequence)
Recommended Name: Integrin alpha-10 precursor  
Size: 1167 amino acids; 127602 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1
Secondary accessions: B2RAM4 Q6UXJ6 Q9UHZ8
Alternative splicing: 2 isoforms:  O75578-1   O75578-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGA10: NX_O75578

Explore proteomics data for ITGA10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn98, Asn234, Asn336, Asn364, Asn733, Asn763, Asn839, Asn921, Asn1011, Asn1018,
                                 Asn1039

  • See ITGA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003628.2  
    ENSEMBL proteins: 
     ENSP00000358310   ENSP00000439894   ENSP00000440011  
    Reactome Protein details: O75578

    ITGA10 Human Recombinant Protein Products:

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    Novus Biologicals ITGA10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ITGA10 

    ITGA10 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA10
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    Browse Antibodies at Cloud-Clone Corp.
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    ITGA10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ITG: Integrins

    4 InterPro protein domains:
     IPR000413 Integrin_alpha
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR002035 VWF_A

    Graphical View of Domain Structure for InterPro Entry O75578

    ProtoNet protein and cluster: O75578

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Find genes that share domains with ITGA10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA10_HUMAN, O75578
    Function: Integrin alpha-10/beta-1 is a receptor for collagen

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005518collagen binding TAS9685391
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ITGA10           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itga10):
     limbs/digits/tail  skeleton 

    Find genes that share phenotypes with ITGA10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Itga10tm1Ref for ITGA10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA10

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA10:
    hsa-mir-335-5p (MIRT017655), hsa-let-7c-5p (MIRT051770)

    Block miRNA regulation of human, mouse, rat ITGA10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA10 (see all 55):
    hsa-miR-3141 hsa-miR-15a hsa-let-7a-2* hsa-miR-486-3p hsa-miR-578 hsa-miR-449a hsa-miR-4267 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidITGA10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA10
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA10

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ITGA10

    Clone
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    GenScript: all cDNA clones in your preferred vector: ITGA10 (NM_003637)
    Sino Biological Human cDNA Clone for ITGA10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA10

    Cell Line
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    ESI BIO PureStem Progenitors for ITGA10: 
    PureStem ES-210, Ecto-ntu Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA10_HUMAN, O75578: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex IEA--

    Find genes that share ontologies with ITGA10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA10 About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Focal Adhesion0.65
    ECM-receptor interaction0.31
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    4Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64
    5L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    CHL1 interactions0.00


    Find genes that share SuperPaths with ITGA10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for ITGA10
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA10 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    3 GeneGo (Thomson Reuters) Pathways for ITGA10
        Cytoskeleton remodeling Integrin outside-in signaling
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling

    3 BioSystems Pathways for ITGA10
        Focal Adhesion
    Integrin-mediated cell adhesion
    Arrhythmogenic right ventricular cardiomyopathy


    3 Reactome Pathways for ITGA10
        Platelet Adhesion to exposed collagen
    Integrin cell surface interactions
    CHL1 interactions


    Selected Kegg Pathways  (Kegg details for ITGA10) (see all 7):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Regulation of actin cytoskeleton
    Hypertrophic cardiomyopathy (HCM)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITGA10
    Interactions:

        GeneGlobe Interaction Network for ITGA10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA10 (O755783 ENSP000003583104) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB1P055563, ENSP000003640944I2D: score=3 STRING: ENSP00000364094
    COL2A1ENSP000003698894STRING: ENSP00000369889
    ACTBENSP000003499604STRING: ENSP00000349960
    ACTG1ENSP000003315144STRING: ENSP00000331514
    ACTN1ENSP000003779414STRING: ENSP00000377941
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion TAS9685391
    GO:0007229integrin-mediated signaling pathway IEA--
    GO:0007411axon guidance TAS--
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with ITGA10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITGA10 (ITA10)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ITGA10 gene: 
    NM_003637.3  

    Unigene Cluster for ITGA10:

    Integrin, alpha 10
    Hs.158237  [show with all ESTs]
    Unigene Representative Sequence: NM_003637
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369304(uc001eoa.3 uc010oyv.2 uc009wiw.3 uc010oyw.2)
    ENST00000468261(uc001enz.1) ENST00000481236 ENST00000539363 ENST00000538811

    miRNA
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    Block miRNA regulation of human, mouse, rat ITGA10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA10 (see all 55):
    hsa-miR-3141 hsa-miR-15a hsa-let-7a-2* hsa-miR-486-3p hsa-miR-578 hsa-miR-449a hsa-miR-4267 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidITGA10 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITGA10
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA10
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      QuantiTect SYBR Green Assays in human, mouse, rat ITGA10
      QuantiFast Probe-based Assays in human, mouse, rat ITGA10

    Additional mRNA sequence: 

    AF074015.1 AF112345.1 AK074563.1 AK304155.1 AK304183.1 AK314255.1 AY358325.1 BC140831.1 
    BC144637.1 

    6 DOTS entries:

    DT.107896  DT.99941629  DT.100775393  DT.423142  DT.75112480  DT.40217003 

    Selected AceView cDNA sequences (see all 57):

    BE349027 N58870 NM_003637 CK821579 BX474556 BM768628 BX474109 AF112345 
    BG898045 BX504849 BM311010 BX504665 AF074015 AA460959 CK000752 AA485068 
    BQ015295 AK074563 AI291926 CF265130 BX504850 BX474009 AA461265 BQ683664 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                          -                                                                                                                                 
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30
    SP1:                                                      
    SP2:                                                      
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for ITGA10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTGTCT
    ITGA10 Expression
    About this image


    ITGA10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 11 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 10 entries
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Node Cells Atrioventricular Node
             Atrioventricular Node
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem SK11, NCr-fac & Meso-prx Progenitor
    ITGA10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.158237

    UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578
    Tissue specificity: Widely expressed with highest expression in muscle and heart. Found in articular cartilage

        Custom PCR Arrays for ITGA10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA10 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga101 , 5 integrin, alpha 101, 5 86.55(n)1
    88.09(a)1
      3 (41.93 cM)5
    2131191  NM_001081053.11  NP_001074522.11 
     966455845 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA106
    integrin, alpha 10
    66(a)
    1 ↔ 1
    AAWZ02040308(703-6941)
    zebrafish
    (Danio rerio)
    Actinopterygii itga101 integrin, alpha 10 59.08(n)
    54.97(a)
      572348  XM_003200156.2  XP_003200204.1 


    ENSEMBL Gene Tree for ITGA10 (if available)
    TreeFam Gene Tree for ITGA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA10 gene
    ITGA12  ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  
    ITGA52  ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  
    ITGA42  
    5 SIMAP similar genes for ITGA10 using alignment to 3 protein entries:     ITA10_HUMAN (see all proteins):
    ITGA11    ITGA2    ITGA1    ITGA3    ITGA7

    Find genes that share paralogs with ITGA10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA10 (see all 525)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs557948321,2
    C--119495760(+) TGTGT-/GT    
       
    /GTGT
    ATGTG
    1 -- int11NA 2
    rs1929843201,2
    --145524319(+) GCCTGC/GCCAAC 1 -- us2k10--------
    rs743727881,2
    C,F--145524517(+) AAGAAG/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1498359731,2
    C--145524903(+) TTGGTC/TTGGGG 1 -- us2k10--------
    rs1458057581,2
    C,F--145525085(+) CGTCAC/TTCACC 2 T I mis12Minor allele frequency- T:0.00NA EU 5875
    rs2012229361,2
    --145525145(+) TTTCTG/TGTGGG 1 -- int10--------
    rs613284631,2
    C--145525376(+) TATAAT/-TGTAT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs614908441,2
    C--145525493(+) AATATA/GTAACA 1 -- int10--------
    rs598228571,2
    --145525533(+) AATATA/GTAACA 1 -- int10--------
    rs1408847881,2
    C--145525582(+) ATAAT-/ATA   
      T
    /TATA
    TATTA
    1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGA10 (145524891 - 145543868 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ITGA10:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15n16CNV Deletion17901297
    dgv46e201CNV Deletion23290073
    esv2422428CNV Duplication17116639
    nsv2710CNV Insertion18451855
    nsv872232CNV Gain21882294
    dgv347n71CNV Gain21882294
    nsv831381CNV Gain17160897
    nsv831370CNV Gain17160897
    dgv105e1CNV Complex17122850
    nsv7181OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA10
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604042    OMIM disorders: --


    Find genes that share disorders with ITGA10           About GenesLikeMe


    Export disorders for ITGA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA10 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ITGA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization. (PubMed id 10702680)1, 2, 3, 9 Lehnert K.... Krissansen G.W. (Cytogenet. Cell Genet. 1999)
    2. Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes. (PubMed id 9685391)1, 2, 3 Camper L.... Lundgren-Aakerlund E. (J. Biol. Chem. 1998)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. (PubMed id 16684505)1 Wenke A.K....Bosserhoff A.K. (Biochem. Biophys. Res. Commun. 2006)
    5. Loss of alpha10beta1 integrin expression leads to moderate dysfunction of growth plate chondrocytes. (PubMed id 15713743)1 Bengtsson T....FAossler R. (J. Cell. Sci. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants. (PubMed id 11731273)1 Bengtsson T....Lundgren-Akerlund E. (Matrix Biol. 2001)
    9. Chondrocyte-matrix attachment complexes mediate survival and differentiation. (PubMed id 9822998)1 Svoboda K.K. (Microsc. Res. Tech. 1998)
    10. Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules. (PubMed id 9359872)1 Brakebusch C....FAossler R. (J. Cell. Sci. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8515 HGNC: 6135 AceView: ITGA10 Ensembl:ENSG00000143127 euGenes: HUgn8515
    ECgene: ITGA10 Kegg: 8515 H-InvDB: ITGA10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ITGA10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITGA10 gene:
    Search GeneIP for patents involving ITGA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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