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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ITGA10 Gene

protein-coding GIFtS: 56
GCID: GC01P145524

integrin, alpha 10

Search for ITGA10
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Integrin, Alpha 10¹ ²
PRO827²
Integrin Alpha-10²

External Ids:	HGNC: 6135¹	Entrez Gene: 8515²	Ensembl: ENSG00000143127⁷	OMIM: 604042⁵	UniProtKB: O75578³

Export aliases for ITGA10 gene to outside databases

Previous GC identifers: GC01P144045 GC01P142112 GC01P143252 GC01P143273 GC01P143014 GC01P144236 GC01P119488

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA10:

Integrins are integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in

cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin

beta 1 chain (ITGB1) to form a novel collagen type II-binding integrin expressed in cartilage tissue. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578

Function: Integrin alpha-10/beta-1 is a receptor for collagen

Gene Wiki entry for ITGA10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_167185.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ITGA10 gene promoter:
USF1 RP58 AML1a POU3F1 HTF Egr-2 NRF-2 Sox9 Cart-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGA10 promoter sequence

Search SABiosciences Chromatin IP Primers for ITGA10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

ITGA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA10 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P145524: view genomic region (about GC identifiers)

Start:	145,524,891 bp from pter	End:	145,543,868 bp from pter
Size:	18,978 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578 (See protein sequence)

Recommended Name: Integrin alpha-10 precursor

Size: 1167 amino acids; 127602 Da

Subunit: Heterodimer of an alpha and a beta subunit. Alpha-10 associates with beta-1

Subcellular location: Membrane; Single-pass type I membrane protein

Secondary accessions: B2RAM4 Q6UXJ6 Q9UHZ8

Alternative splicing: 2 isoforms: O75578-1 O75578-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ITGA10: NX_O75578

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O75578

ITGA10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003628.2

ENSEMBL proteins:

ENSP00000358310 ENSP00000439894 ENSP00000440011

Reactome Protein details: O75578
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ITGA10 OriGene Protein Over-expression Lysate: ITGA10 OriGene Custom Protein Services for ITGA10
	GenScript Custom Purified and Recombinant Proteins Services for ITGA10
	Novus Biologicals ITGA10 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0008305	integrin complex	IEA	--

ITGA10 for ontologies About GeneDecksing

ITGA10 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA10
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	Browse OriGene Antibodies OriGene Custom Antibody Services for ITGA10
	GenScript Custom Superior Antibodies Services for ITGA10
	Novus Biologicals ITGA10 Antibody
	Search for Antibodies for ITGA10 at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for ITGA10

Assay Products for ITGA10:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ITGA10
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ITGA10 for domains About GeneDecksing

4 InterPro domains/families:

IPR000413 Integrin_alpha

IPR013519 Int_alpha_beta-p

IPR013649 Integrin_alpha-2

IPR002035 VWF_A

Graphical View of Domain Structure for InterPro Entry O75578

ProtoNet protein and cluster: O75578

4 Blocks protein families:

IPB000413 Integrins alpha chain

IPB002035 Von Willebrand factor type A domain signature

IPB013513 Integrin alpha chain

IPB013517 FG-GAP

UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578

Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage

Similarity: Belongs to the integrin alpha chain family

Similarity: Contains 7 FG-GAP repeats

Similarity: Contains 1 VWFA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578

Function: Integrin alpha-10/beta-1 is a receptor for collagen

miRNA Products:		OriGene 3'-UTR Clone: ITGA10 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA10
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA10 (see all 55):
		hsa-miR-3141 hsa-miR-15a hsa-let-7a-2* hsa-miR-486-3p hsa-miR-578 hsa-miR-449a hsa-miR-4267 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: ITGA10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA10 (see all 7) OriGene shRNA RFP: ITGA10 OriGene siRNA: ITGA10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA10

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ITGA10

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGA10 (NM_003637)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA10

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ITGA10
		LifeMap BioReagents: cell lines associated with ITGA10: PureStem ES-210, Ecto-ntu Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA10

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	--	--
GO:0005518	collagen binding	TAS	9685391
GO:0046872	metal ion binding	IEA	--

ITGA10 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Itga10^tm1Ref for ITGA10
     2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Itga10):

limbs/digits/tail

skeleton

ITGA10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56

Apoptotic Pathways in Synovial Fibroblasts

PPAR Pathway	0.66	Actin-Based Motility by Rho Family GTPases	0.52
Rac1 Pathway	0.58	Rap1 Pathway	0.42
Glioma Invasiveness	0.54

Cell adhesion_Integrin-mediated cell adhesion and migration

	Cell adhesion_Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling Integrin outside-in signaling	0.37
	Cell adhesion Integrin-mediated cell adhesion and migration	1.00			Cytoskeleton remodeling_Integrin outside-in signaling	0.37

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			RhoA Pathway	0.35
	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61			MAPK Signaling	0.51

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for ITGA10

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Integrin inside-out signaling

1 R&D Systems Pathway for ITGA10

Articular Cartilage Extracellular Matrix

5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA10 (see all 33)

	RhoA Pathway
	Paxillin Interactions
	Molecular Mechanisms of Cancer
	CDK5 Pathway
	Tec Kinases Signaling

3 GeneGo (Thomson Reuters) Pathways for ITGA10

	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion Integrin inside-out signaling

3 BioSystems Pathways for ITGA10

	Integrin-mediated cell adhesion
	Focal Adhesion
	Arrhythmogenic right ventricular cardiomyopathy

2 Reactome Pathways for ITGA10

	Integrin cell surface interactions
	Signal Transduction

5/6 Kegg Pathways (Kegg details for ITGA10) (see all 6):

	Focal adhesion
	ECM-receptor interaction
	Regulation of actin cytoskeleton
	Hypertrophic cardiomyopathy (HCM)
	Arrhythmogenic right ventricular cardiomyopathy (ARVC)

ITGA10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ITGA10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/93 Interacting proteins for ITGA10 (O75578³ ENSP00000358310⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 93)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGB1	P05556³, ENSP00000364094⁴	I2D: score=3 STRING: ENSP00000364094
COL2A1	ENSP00000369889⁴	STRING: ENSP00000369889
ACTB	ENSP00000349960⁴	STRING: ENSP00000349960
ACTG1	ENSP00000331514⁴	STRING: ENSP00000331514
ACTN1	ENSP00000377941⁴	STRING: ENSP00000377941

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	--	--
GO:0007160	cell-matrix adhesion	TAS	9685391
GO:0007229	integrin-mediated signaling pathway	IEA	--

ITGA10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ITGA10
Search CenterWatch for drugs/clinical trials and news about ITGA10 / ITA10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ITGA10 gene:

NM_003637.3

Unigene Cluster for ITGA10:

Integrin, alpha 10

Hs.158237 [show with all ESTs]

Unigene Representative Sequence: NM_003637

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369304(uc001eoa.3 uc010oyv.2 uc009wiw.3 uc010oyw.2)

ENST00000468261(uc001enz.1) ENST00000481236 ENST00000539363 ENST00000538811

miRNA Products:		OriGene 3'-UTR Clone: ITGA10 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA10
		8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA10 (see all 55):
		hsa-miR-3141 hsa-miR-15a hsa-let-7a-2* hsa-miR-486-3p hsa-miR-578 hsa-miR-449a hsa-miR-4267 hsa-miR-424

		SwitchGear 3'UTR luciferase reporter plasmid: ITGA10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA10 (see all 7) OriGene shRNA RFP: ITGA10 OriGene siRNA: ITGA10
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITGA10

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA10 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA10 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ITGA10 (NM_003637)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA10
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGA10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGA10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA10

Additional cDNA sequence:

AF074015.1 AF112345.1 AK074563.1 AK304155.1 AK304183.1 AK314255.1 AY358325.1 BC140831.1

BC144637.1

6 DOTS entries:

DT.107896 DT.99941629 DT.100775393 DT.423142 DT.75112480 DT.40217003

24/57 AceView cDNA sequences (see all 57):

BE349027 BX474109 AF112345 N58870 NM_003637 CK821579 BM768628 BX474556

BX504665 AF074015 BX474527 AA461266 BX504849 CF265130 CK000752 BX504850

BX474009 BQ007173 AA460959 AK074563 BM992008 AA485068 BQ683664 AL710595

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ITGA10 About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^
SP1:									-
SP2:
SP3:
SP4:

ExUns:	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30
SP1:
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for ITGA10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ITGA10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCATTGTCT

About this image

ITGA10 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Bone

Lumbar Vertebral Body

Somite

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor EN7 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)

Adipose, Bone, Cartilage

HyStem+TGF?3+GDF5-induced MEL2 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced E15 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

See ITGA10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITGA10

SOURCE GeneReport for Unigene cluster: Hs.158237

UniProtKB/Swiss-Prot: ITA10_HUMAN, O75578

Tissue specificity: Widely expressed with highest expression in muscle and heart. Found in articular cartilage

SABiosciences Custom PCR Arrays for ITGA10

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITGA10 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ITGA10
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITGA10
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ITGA10 gene from 3/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	ITGA10⁶ --	--	68(a) 20(a)	1 ↔ 1 possible ortholog	AAWZ02040308(745-6941) GL343516.1(252432-271527)
zebrafish (Danio rerio)	Actinopterygii	itga10¹	integrin, alpha 10	58.84(n) 54.53(a)		572348 XM_003200156.1 XP_003200204.1
fruit fly (Drosophila melanogaster)	Insecta	alphaPS5⁶ scb⁶ (see all 3)	scab (see all 3)	18(a) 17(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2R(19444333-19447720) 2R(11136290-11146003)

ENSEMBL Gene Tree for ITGA10 (if available)
TreeFam Gene Tree for ITGA10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ITGA10 gene

ITGA1² ITGA6² ITGA3² ITGA7² ITGA8² ITGAM² ITGA11² ITGA2²

ITGA5² ITGAE² ITGAD² ITGA2B² ITGAV² ITGAX² ITGAL² ITGA9²

ITGA4²

5 SIMAP similar genes for ITGA10 using alignment to 3 protein entries: ITA10_HUMAN (see all proteins):

ITGA11 ITGA2 ITGA1 ITGA3 ITGA7

ITGA10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79946320^1,2	F,	--	145523048(+)	`GTGGAG/AGAAGA`	2	--	ut3¹		1		WA	118
rs3754340^1,2	C,F,H,	--	145523283(-)	`ATCAAA/CAAGTA`	2	--	ut3¹		13		EA NS NA CSA	2986
rs3754339^1,2	C,H	--	145523570(-)	`AGACTG/AGGGAA`	2	--	ut3¹ tfbs³		5		NS EA NA	420
rs191104767^1,2		--	145523598(+)	`GCTTAC/TCCAGA`	2	--	ut3¹		0	--	--	--	--
rs183700409^1,2		--	145523728(+)	`CTCATC/TGACAT`	2	--	ut3¹		0	--	--	--	--
rs3754338^1,2	C,F,H,	--	145523906(-)	`AGTTGG/AGAGTG`	2	--	int¹		10		EA NS NA	2414
rs75406549^1,2	F,	--	145523964(+)	`GTCTAA/GTACTA`	2	--	int¹		2		WA EA	238
rs142311694^1,2		--	145524091(+)	`GTGGGA/GCTGGT`	2	--	int¹		0	--	--	--	--
rs186888706^1,2		--	145524137(+)	`CCCCTA/GGGTGG`	2	--	int¹		0	--	--	--	--
rs114905374^1,2	F,	--	145524224(+)	`AATCTA/GTCGGC`	2	--	int¹		1		NA	120

HapMap Linkage Disequilibrium report for ITGA10 (145524891 - 145543868 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ITGA10
4 CNVs: 48114 2324 5199 53561

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ITGA10 for disorders About MalaCards

ITGA10 for disorders About GeneDecksing

OMIM gene information: 604042 OMIM disorders: --

Export disorders for ITGA10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ITGA10 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with ITGA10)

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The integrin alpha10 subunit: expression pattern, partial gene structure, and chromosomal localization. (PubMed id 10702680)^{1, 2, 3, 9} Lehnert K.... Krissansen G.W. (1999)
Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes. (PubMed id 9685391)^{1, 2, 3} Camper L.... Lundgren-Aakerlund E. (1998)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1. (PubMed id 16684505)¹ Wenke A.K....Bosserhoff A.K. (2006)
Loss of alpha10beta1 integrin expression leads to mod erate dysfunction of growth plate chondrocytes. (PubMed id 15713743)¹ Bengtsson T....FAossler R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Characterization of the mouse integrin subunit alpha10 gene and comparison with its human homologue. Genomic structure, chromosomal localization and identification of splice variants. (PubMed id 11731273)¹ Bengtsson T....Lundgren-Akerlund E. (2001)
Chondrocyte-matrix attachment complexes mediate survival and differentiation. (PubMed id 9822998)¹ Svoboda K.K. (1998)
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules. (PubMed id 9359872)¹ Brakebusch C....Fassler R. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8515	HGNC: 6135	AceView: ITGA10	Ensembl:ENSG00000143127	euGenes: HUgn8515
ECgene: ITGA10	Kegg: 8515	H-InvDB: ITGA10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ITGA10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ITGA10	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ITGA10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ITGA10 gene:
Search GeneIP for patents involving ITGA10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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