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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA1 Gene

protein-coding   GIFtS: 59
GCID: GC05P052083

integrin, alpha 1
 Explore 51 diseases affiliated with
ITGA1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ITGA1    

Aliases
for ITGA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Integrin, Alpha 11 2     CD49 Antigen-Like Family Member A2 3
VLA11 2 5     Integrin Alpha-12
CD49a1 2     Very Late Activation Protein 12
Laminin And Collagen Receptor2 3     CD49a Antigen3
VLA-12 3     

External Ids:    HGNC: 61341   Entrez Gene: 36722   Ensembl: ENSG000002139497   OMIM: 1929685   UniProtKB: P561993   

Export aliases for ITGA1 gene to outside databases

Previous GC identifers: GC05P052249 GC05U900017 GC05P052099 GC05P052119 GC05P049056


Summaries
for ITGA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ITGA1:
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to
form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion
and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor
type I domain which is thought to be involved in collagen binding. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated
sequence G-F-P-G-E-R in collagen

Gene Wiki entry for ITGA1 (CD49a)


Genomic Views
for ITGA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA1 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   AP-1   SRF (504 AA)   POU2F2   Evi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ITGA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.1

ITGA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052083:  view genomic region     (about GC identifiers)

Start:
 52,083,730 bp from pter      End:
 52,252,327 bp from pter
Size:
 168,598 bases      Orientation:
 plus strand

Proteins
for ITGA1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199 (See protein sequence)
Recommended Name: Integrin alpha-1 precursor  
Size: 1179 amino acids; 130848 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21
Subcellular location: Membrane; Single-pass type I membrane protein
5 PDB 3D structures from and Proteopedia for ITGA1:
1PT6 (3D)        1QC5 (3D)        1QCY (3D)        2L8S (3D)        4A0Q (3D)    
Secondary accessions: B2RNU0

Explore the universe of human proteins at neXtProt for ITGA1: NX_P56199

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P56199

    • ITGA1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_852478.1  
    ENSEMBL proteins: 
     ENSP00000282588  
    Reactome Protein details: P56199
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for ITGA1 (Integrin alpha 1 beta 1)
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    OriGene Protein Over-expression Lysate: ITGA1
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    Novus Biologicals ITGA1 Proteins
    Novus Biologicals ITGA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005624membrane fraction ----
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS8428973
    GO:0009897external side of plasma membrane IEA--


    ITGA1 for ontologies           About GeneDecksing



    ITGA1 Antibody Products: 
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    ThermoFisher Antibody for ITGA1

    Assay Products for ITGA1: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ITGA1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ITGA1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000413 Integrin_alpha
     IPR013519 Int_alpha_beta-p
     IPR018184 Integrin_alpha_C_CS
     IPR013517 FG-GAP
     IPR013649 Integrin_alpha-2

    Graphical View of Domain Structure for InterPro Entry P56199

    ProtoNet protein and cluster: P56199

    4 Blocks protein families:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    Function
    for ITGA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
    Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated
    sequence G-F-P-G-E-R in collagen

         Genatlas biochemistry entry for ITGA1:
    integrin,alpha 1,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB1 in collagen,laminin receptors

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ITGA1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ITGA1 (see all 9):
    hsa-miR-3163 hsa-miR-3679-5p hsa-miR-3065-5p hsa-miR-578 hsa-miR-1185 hsa-miR-1304 hsa-miR-544b hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmid: ITGA1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITGA1 (see all 6)
    Browse OriGene siRNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ITGA1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITGA1 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ITGA1 (NM_181501)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA1 

    Cell Line
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    Search LifeMap BioReagents cell lines for ITGA1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA1

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI16754661
    GO:0005518collagen binding TAS8428973
    GO:0046872metal ion binding IEA--


    ITGA1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ITGA1:
     Elongated cells 

    Animal Models:
         Mouse knock-out Itga1tm1Gdnr for ITGA1
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Itga1):
     cellular  homeostasis/metabolism  immune system  renal/urinary system 

    ITGA1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ITGA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/35 super-pathways (see all 35) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    2Apoptotic Pathways in Synovial Fibroblasts
    		PPAR Pathway0.66
    		Actin-Based Motility by Rho Family GTPases0.52
    		Rac1 Pathway0.58
    		Rap1 Pathway0.42
    		Glioma Invasiveness0.54
    3Cell adhesion_Integrin-mediated cell adhesion and migration
    		Cell adhesion_Integrin-mediated cell adhesion and migration1.00
    		Cell adhesion_Endothelial cell contacts by non-junctional mechanisms0.21
    		Cell adhesion Integrin-mediated cell adhesion and migration1.00
    		Cell adhesion Endothelial cell contacts by non-junctional mechanisms0.21
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		RhoA Pathway0.35
    		Actin Nucleation and Branching0.66
    		CDC42 Pathway0.34
    5Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    		MAPK Signaling0.51

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 EMD Millipore Pathways for ITGA1
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA1 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for ITGA1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling

    5/9 BioSystems Pathways for ITGA1 (see all 9) 
        Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    Arrhythmogenic right ventricular cardiomyopathy
    CXCR4-mediated signaling events
    Signaling events mediated by TCPTP

    5/10        Reactome Pathways for ITGA1 (see all 10)
        L1CAM interactions
    Developmental Biology
    Integrin cell surface interactions
    Smooth Muscle Contraction
    Other semaphorin interactions


    5/7         Kegg Pathways  (Kegg details for ITGA1) (see all 7):
        Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage
    Regulation of actin cytoskeleton
    Hypertrophic cardiomyopathy (HCM)


    ITGA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/135 Interacting proteins for ITGA1 (P561992, 3 ENSP000002825884) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN2P177062, 3, ENSP000003118574MINT-8284727 MINT-8284737 I2D: score=1 STRING: ENSP00000311857
    BIN1O004993, ENSP000003167794I2D: score=2 STRING: ENSP00000316779
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    TLN1Q9Y4903, ENSP000003160294I2D: score=2 STRING: ENSP00000316029
    COL8A1P276583, ENSP000002610374I2D: score=1 STRING: ENSP00000261037
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0006936muscle contraction TAS--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion NAS--
    GO:0007229integrin-mediated signaling pathway IEA--


    ITGA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ITGA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ITGA1
    9 Novoseek chemical compound relationships for ITGA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 37.5 1 18775695 (1)
    wortmannin 8.49 1 16289050 (1)
    magnesium 0 2 2380249 (1), 10457223 (1)
    lysine 0 1 11336656 (1)
    oxygen 0 1 16807282 (1)
    progesterone 0 2 9009235 (1)
    tyrosine 0 2 11336656 (1), 16472776 (1)
    estrogen 0 1 19780039 (1)
    dexamethasone 0 1 9618153 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGA1 / ITA1 

    Transcripts
    for ITGA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ITGA1 gene: 
    NM_181501.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282588(uc003jou.3 uc003jov.3) ENST00000504086 ENST00000514262
    ENST00000513737 ENST00000509049 ENST00000504669(uc003jow.3) ENST00000506275


    miRNA
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    hsa-miR-3163 hsa-miR-3679-5p hsa-miR-3065-5p hsa-miR-578 hsa-miR-1185 hsa-miR-1304 hsa-miR-544b hsa-miR-3134
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    Inhib. RNA
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    Clone
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    Primer
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    24/542 AceView cDNA sequences (see all 542):

    BM544371 BM927428 BM453706 BE274351 AW292142 BQ058833 BM924055 BQ057226 
    CR599988 BQ056647 BQ066140 CB148171 AA327614 BQ066311 CR599348 AA575956 
    AL709969 BM788674 BU957270 NM_181501 BE384077 AA043379 BX641792 AI091136 

    GeneLoc Exon Structure


    Expression
    for ITGA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ITGA1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Nucleus Pulposus CellsCartilage
    LimbAutopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbStylopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    HyStem+BMP4-induced SK11 cells (HyStem+BMP4 inductio...)Bone, Cartilage

    See ITGA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA1
        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA1 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Wound Healing in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITGA1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA1

    Orthologs
    for ITGA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ITGA1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ITGA11 integrin, alpha 1 72.2(n)
    70.85(a)    		   395951  NM_205069.1  NP_990400.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ITGA16
    --
    		 --
    		 68(a)
    18(a)
    		 1 ↔ 1
    possible ortholog
    		 2(3643435-3686438)
    GL343516.1(252432-271527)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.243762 Xenopus laevis transcribed sequence with moderate similarity more 75.71(n)    48020794 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc565502 similar to pelota homolog (Drosophila) 76.56(n)   394111  BC049484.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta alphaPS56
    scb6
    (see all 3)    		 scab
    (see all 3)    		 17(a)
    15(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2R(19444333-19447720)
    2R(11136290-11146003)


    ENSEMBL Gene Tree for ITGA1 (if available)
    TreeFam Gene Tree for ITGA1 (if available) 

    Paralogs
    for ITGA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA1 gene
    ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    4 SIMAP similar genes for ITGA1 using alignment to 1 protein entry:     ITA1_HUMAN:
    ITGA2    ITGA11    ITGA10    COL21A1

    ITGA1 for paralogs           About GeneDecksing



    Genomic Variants
    for ITGA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2993 NCBI SNPs in ITGA1 are shown (see all 2993)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1407790341,2
    		Cother52216207(+) ATCACG/AAAGTT 2 /Q /R mis11Minor allele frequency- A:0.00NA 4538
    rs1513081761,2
    		--52082155(+) GTATGC/TATATG 2 -- us2k10--------
    rs1895827671,2
    		--52082190(+) ATACAC/TACACA 2 -- us2k10--------
    rs1405444551,2
    		--52082386(+) GGAAAC/GGAGAT 2 -- us2k10--------
    rs1497028561,2
    		--52082431(+) GAGCAC/TTGAAC 2 -- us2k10--------
    rs168802381,2
    		C,F,H,--52082563(+) CTAAAA/CACGGG 2 -- us2k18Minor allele frequency- C:0.12NA NS EA 682
    rs104718131,2
    		C,F,H,--52082618(+) GATACA/TTAATA 2 -- us2k19Minor allele frequency- T:0.15NS EA WA NA 782
    rs64500811,2
    		C,F,A,H,--52082697(+) CCCACA/C/TCCATT 2 -- us2k17NS EA WA CSA 539
    rs774105491,2
    		--52082712(+) ACGCTC/TCTTAA 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs48657441,2
    		C,F,H,--52082774(+) TGGCAG/ATGTAT 2 -- us2k127Minor allele frequency- A:0.08NA NS EA WA CSA 2384

    HapMap Linkage Disequilibrium report for ITGA1 (52083730 - 52252327 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for ITGA1
         2 CNVs: 99134 99135
         8 Indels: 12683 46896 42006 12682 27953 62374 40754 40755

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    Disorders / Diseases
    for ITGA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ITGA1 for disorders           About GeneDecksing

    OMIM gene information: 192968    OMIM disorders: --

    20/51 diseases for ITGA1 (see all 51):    About MalaCards
    gilles de la tourette syndrome    attention deficit hyperactivity disorder    fibrosis    pre-eclampsia
    mycosis fungoides    tourette syndrome    b-cell lymphomas    phimosis
    polycystic kidney disease    hearing loss    colon carcinoma in situ    angiofibroma
    brain ischemia    kidney disease    eclampsia    colon carcinoma
    hepatocellular carcinoma    cervical cancer    endometrial adenocarcinoma    rheumatoid arthritis

    1 disease from the University of Copenhagen DISEASES database for ITGA1:
    Colon carcinoma in situ

    10/12 Novoseek disease relationships for ITGA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 17.7 1 9403732 (1)
    tumors 17.5 9 17982677 (1), 1711920 (1), 8864174 (1), 18579572 (1) (see all 6)
    metastasis 16 4 8105045 (3), 15679046 (1)
    necrosis 14.1 1 1869591 (1)
    hepatocellular carcinoma 12.9 2 9824613 (2)
    psoriasis 6.81 4 18269595 (3), 17603494 (1)
    breast carcinoma 0 1 1711920 (1)
    cervical cancer 0 1 7573248 (1)
    colitis 0 2 2341567 (2)
    influenza 0 3 17372009 (2)

    Genetic Association Database (GAD): ITGA1
    Human Genome Epidemiology (HuGE) Navigator: ITGA1 (11 documents)

    Export disorders for ITGA1 gene to outside databases

    Publications
    for ITGA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA1 gene, integrated from 9 sources (see all 212):
    (articles sorted by number of sources associating them with ITGA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of native and truncated forms of the human integrin alpha 1 subunit. (PubMed id 8428973)1, 2, 3, 9 Briesewitz R.... Marcantonio E.E. (1993)
    2. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    3. Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1. (PubMed id 14660600)1, 2 Nymalm Y....Salminen T.A. (2004)
    4. Platelet GPIaC807T polymorphism is associated with negative outcome of sudden hearing loss. (PubMed id 15109703)1, 4 Rudack C....Junker R. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    6. Antiphospholid antibodies regulate the expression of trophoblast cell adhesion molecules. (PubMed id 11937138)1, 3 Di Simone N....Caruso A. (2002)
    7. Platelet hyperreactivity after coronary artery bypass grafting: the possible relevance to glycoprotein polymorphisms. A preliminary report. (PubMed id 11454259)1, 4 Golanski J....Watala C. (2001)
    8. [Study of C807T polymorphism of the platelet collagen receptor alpha2 gene coding sequence in Suzhou Han population] (PubMed id 11877061)1, 4 Shi J....Ruan C. (2001)
    9. Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM. (PubMed id 10455165)1, 2 Rich R.L.... Hook M. (1999)
    10. Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion. (PubMed id 17982677)1, 9 Van Slambrouck S....Steelant W.F. (2007)

    External Searches for ITGA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ITGA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3672 HGNC: 6134 AceView: PELO Ensembl:ENSG00000213949 euGenes: HUgn3672
    ECgene: ITGA1 Kegg: 3672 H-InvDB: ITGA1

    Other Databases showing ITGA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ITGA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ITGA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ITGA1 gene:
    Search GeneIP for patents involving ITGA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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