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ITGA1 Gene

protein-coding   GIFtS: 62
GCID: GC05P052083

Integrin, Alpha 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Integrin, Alpha 11 2     CD49a2
Laminin And Collagen Receptor2 3     Integrin Alpha-12
VLA-12 3     Very Late Activation Protein 12
CD49 Antigen-Like Family Member A2 3     CD49a Antigen3
VLA12 5     

External Ids:    HGNC: 61341   Entrez Gene: 36722   Ensembl: ENSG000002139497   OMIM: 1929685   UniProtKB: P561993   

Export aliases for ITGA1 gene to outside databases

Previous GC identifers: GC05P052249 GC05U900017 GC05P052099 GC05P052119 GC05P049056


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ITGA1 Gene:
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit
to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell
adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von
Willebrand factor type I domain which is thought to be involved in collagen binding. (provided by RefSeq, Jul
2008)

GeneCards Summary for ITGA1 Gene:
ITGA1 (integrin, alpha 1) is a protein-coding gene. Diseases associated with ITGA1 include colon carcinoma in situ, and phimosis. GO annotations related to this gene include protein phosphatase binding and protein heterodimerization activity. An important paralog of this gene is ITGA6.

UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated
sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell
growth

summary for ITGA1 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA1 (CD49a) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ITGA1 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   AP-1   SRF (504 AA)   POU2F2   Evi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA1 promoter sequence
   Search Chromatin IP Primers for ITGA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITGA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.1

ITGA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052083:  view genomic region     (about GC identifiers)

Start:
52,083,730 bp from pter      End:
52,255,040 bp from pter
Size:
171,311 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199 (See protein sequence)
Recommended Name: Integrin alpha-1 precursor  
Size: 1179 amino acids; 130848 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.
Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively
regulates EGF signaling
6 PDB 3D structures from and Proteopedia for ITGA1:
1PT6 (3D)        1QC5 (3D)        1QCY (3D)        2L8S (3D)        2M32 (3D)        4A0Q (3D)    
Secondary accessions: B2RNU0

Explore the universe of human proteins at neXtProt for ITGA1: NX_P56199

Explore proteomics data for ITGA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn74, Asn100, Asn105, Asn112, Asn217, Asn317, Asn341, Asn402, Asn418, Asn460,
                                 Asn532, Asn699, Asn748, Asn780, Asn840, Asn883, Asn908, Asn915, Asn939, Asn966 (see all 26)
  • Modification sites at PhosphoSitePlus

  • See ITGA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_852478.1  
    ENSEMBL proteins: 
     ENSP00000282588  
    Reactome Protein details: P56199

    ITGA1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant ITGA1 Protein
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    Novus Biologicals ITGA1 Proteins
    Novus Biologicals ITGA1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ITGA1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ITGA1
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    Search for Antibodies for ITGA1 at Abcam
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    LSBio Antibodies in human, mouse, rat for ITGA1

    ITGA1 Assay Products:

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    GenScript Custom Assay Services for ITGA1
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    Browse ELISAs at Cloud-Clone Corp.
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ITG: Integrins

    Selected InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P56199

    ProtoNet protein and cluster: P56199

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA1_HUMAN, P56199
    Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated
    sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell
    growth

         Genatlas biochemistry entry for ITGA1:
    integrin,alpha 1,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB1 in collagen,laminin receptors

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI16754661
    GO:0005518collagen binding TAS8428973
    GO:0019903protein phosphatase binding IPI15592458
         
    ITGA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGA1:
     Elongated cells 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itga1):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    ITGA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itga1tm1Gdnr for ITGA1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ITGA1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ITGA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ITGA1:
    hsa-mir-1 (MIRT023883), hsa-mir-335-5p (MIRT018439)

    Block miRNA regulation of human, mouse, rat ITGA1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ITGA1 (see all 9):
    hsa-miR-3163 hsa-miR-3679-5p hsa-miR-3065-5p hsa-miR-578 hsa-miR-1185 hsa-miR-1304 hsa-miR-544b hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidITGA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ITGA1
    Predesigned siRNA for gene silencing in human, mouse, rat ITGA1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ITGA1

    Clone
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    OriGene clones in human, mouse for ITGA1 (see all 6)
    OriGene ORF clones in mouse, rat for ITGA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ITGA1 (NM_181501)
    Sino Biological Human cDNA Clone for ITGA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ITGA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITGA1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ITA1_HUMAN, P56199: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS8428973
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----

    ITGA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ITGA1 About   (see all 37)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal adhesion
    Focal adhesion0.65
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    ECM-receptor interaction0.31
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    3Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    4Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56
    5Apoptotic Pathways in Synovial Fibroblasts
    PPAR Pathway0.66
    Actin-Based Motility by Rho Family GTPases0.62
    Rac1 Pathway0.65
    Rap1 Pathway0.57
    Glioma Invasiveness0.64

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ITGA1 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for ITGA1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling

    Selected BioSystems Pathways for ITGA1 (see all 9)
        Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    Arrhythmogenic right ventricular cardiomyopathy
    Signaling events mediated by PRL
    Arf6 trafficking events


    Selected Reactome Pathways for ITGA1 (see all 6)
        Platelet Adhesion to exposed collagen
    Laminin interactions
    Integrin cell surface interactions
    Smooth Muscle Contraction
    Other semaphorin interactions


    Selected Kegg Pathways  (Kegg details for ITGA1) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage
    Regulation of actin cytoskeleton


    ITGA1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA1 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Wound Healing in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ITGA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ITGA1 (P561992, 3 ENSP000002825884) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN2P177062, 3, ENSP000003118574MINT-8284727 MINT-8284737 I2D: score=1 STRING: ENSP00000311857
    BIN1O004993, ENSP000003167794I2D: score=2 STRING: ENSP00000316779
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    TLN1Q9Y4903, ENSP000003160294I2D: score=2 STRING: ENSP00000316029
    COL8A1P276583, ENSP000002610374I2D: score=1 STRING: ENSP00000261037
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0006936muscle contraction TAS--
    GO:0007155cell adhesion IEA--
    GO:0007160cell-matrix adhesion ----
    GO:0007229integrin-mediated signaling pathway IEA--

    ITGA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ITGA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    9 Novoseek inferred chemical compound relationships for ITGA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 37.5 1 18775695 (1)
    wortmannin 8.49 1 16289050 (1)
    magnesium 0 2 2380249 (1), 10457223 (1)
    lysine 0 1 11336656 (1)
    oxygen 0 1 16807282 (1)
    progesterone 0 2 9009235 (1)
    tyrosine 0 2 11336656 (1), 16472776 (1)
    estrogen 0 1 19780039 (1)
    dexamethasone 0 1 9618153 (1)



    ITGA1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ITGA1 gene: 
    NM_181501.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282588(uc003jou.3 uc003jov.3) ENST00000504086 ENST00000514262
    ENST00000513737 ENST00000509049 ENST00000504669(uc003jow.3) ENST00000506275


    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ITGA1 (see all 9):
    hsa-miR-3163 hsa-miR-3679-5p hsa-miR-3065-5p hsa-miR-578 hsa-miR-1185 hsa-miR-1304 hsa-miR-544b hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidITGA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ITGA1
      QuantiFast Probe-based Assays in human, mouse, rat ITGA1

    Selected AceView cDNA sequences (see all 542):

    BQ066147 AI192802 CA772057 BF315941 BX641792 AI972404 AI696364 BE384077 
    CR598605 BQ057925 Z39294 AI074570 BQ054647 BX400814 AA575956 CR599348 
    CR613377 BE274351 BQ063271 CN483840 AI867002 R50724 BQ065724 CB143904 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITGA1 expression in normal human tissues (normalized intensities)      ITGA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ITGA1 Expression
    About this image


    ITGA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Bone Marrow Stromal Cells Bone Marrow
             TGFbeta3+BMP7-induced chondrocytes
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Bone Marrow Stromal Cells Bone Marrow
             TGFbeta3+BMP7-induced chondrocytes
     
     Mesenchymal Stem Cells
             Bone Marrow Stromal Cells Bone Marrow
     
     Peripheral Nervous System (Nervous System)
             Non-myelinating Schwann Cells Peripheral Nerve Domain
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Autopod
    ITGA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITGA1 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ITGA1 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Wound Healing in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ITGA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITGA1
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    QuantiFast Probe-based Assays in human, mouse, rat ITGA1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga11 , 5 integrin alpha 11, 5 84.75(n)1
    88.03(a)1
      13 (64.61 cM)5
    1097001  NM_001033228.31  NP_001028400.21 
     1149580795 
    chicken
    (Gallus gallus)
    Aves ITGA11 integrin, alpha 1 72.2(n)
    70.85(a)
      395951  NM_205069.1  NP_990400.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA16
    integrin, alpha 1
    68(a)
    1 ↔ 1
    2(3643435-3686438)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243762 Xenopus laevis transcribed sequence with moderate similarity more 75.71(n)    48020794 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565502 similar to pelota homolog (Drosophila) 76.56(n)   394111  BC049484.1 


    ENSEMBL Gene Tree for ITGA1 (if available)
    TreeFam Gene Tree for ITGA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITGA1 gene
    ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA42  
    ITGA102  
    4 SIMAP similar genes for ITGA1 using alignment to 1 protein entry:     ITA1_HUMAN:
    ITGA2    ITGA11    ITGA10    COL21A1

    ITGA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITGA1 (see all 3332)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407790341,2
    Cuntested152216207(+) ATCACG/AAAGTT 2 /Q /R mis11Minor allele frequency- A:0.00NA 4538
    rs1420655401,2
    --52098978(+) CTGTGA/GGCCTT 1 -- int10--------
    rs1130372501,2
    C,F--52099080(+) ACTTTG/AAAACT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs11571371,2
    C--52099093(+) CATATT/GTATAT 1 -- int112Minor allele frequency- G:0.10MN NA WA CSA EA 555
    rs92919941,2
    C,F--52099095(+) TATGTA/TTATTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs709744721,2
    C--52099160(+) TCCGT-/GAGT  
            
    ATCTT
    1 -- int11Minor allele frequency- GAGT:0.00NA 2
    rs92919951,2
    C,F,H--52099436(+) GCAGCC/TCAGAC 1 -- int114Minor allele frequency- T:0.14NS EA NA WA CSA 784
    rs1882541171,2
    --52099453(+) AATAAC/TGTTTT 1 -- int10--------
    rs623584441,2
    C--52099482(+) TTTAAA/GGCTAC 1 -- int14Minor allele frequency- G:0.22NA WA EA 360
    rs1914976781,2
    --52099632(+) ACAGGC/TGCTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGA1 (52083730 - 52255040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ITGA1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730175CNV Deletion23290073
    esv2730174CNV Deletion23290073
    esv2730176CNV Deletion23290073
    esv2399032CNV Deletion18987734
    esv2590093CNV Deletion19546169
    esv1295358CNV Deletion17803354
    esv3407CNV Deletion18987735
    esv1167986CNV Deletion17803354
    esv1002775CNV Deletion20482838
    dgv197n6CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITGA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ITGA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 192968    OMIM disorders: --

    Selected diseases for ITGA1 (see all 49):    About MalaCards
    colon carcinoma in situ    phimosis    gilles de la tourette syndrome    brain ischemia
    mycosis fungoides    attention deficit hyperactivity disorder    eosinophilia    influenza
    cervical cancer    peripheral neuropathy    endometrial adenocarcinoma    polycystic kidney disease
    tonsillitis    kidney disease    hypertrophic cardiomyopathy    psoriasis
    scleroderma    sarcoidosis    cervicitis    eclampsia

    1 disease from the University of Copenhagen DISEASES database for ITGA1:
    Colon carcinoma in situ

    ITGA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for ITGA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 17.7 1 9403732 (1)
    tumors 17.5 9 17982677 (1), 1711920 (1), 8864174 (1), 18579572 (1) (see all 6)
    metastasis 16 4 8105045 (3), 15679046 (1)
    necrosis 14.1 1 1869591 (1)
    hepatocellular carcinoma 12.9 2 9824613 (2)
    psoriasis 6.81 4 18269595 (3), 17603494 (1)
    breast carcinoma 0 1 1711920 (1)
    cervical cancer 0 1 7573248 (1)
    colitis 0 2 2341567 (2)
    influenza 0 3 17372009 (2)

    Genetic Association Database (GAD): ITGA1
    Human Genome Epidemiology (HuGE) Navigator: ITGA1 (11 documents)

    Export disorders for ITGA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITGA1 gene, integrated from 10 sources (see all 223):
    (articles sorted by number of sources associating them with ITGA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of native and truncated forms of the human integrin alpha 1 subunit. (PubMed id 8428973)1, 2, 3, 9 Briesewitz R.... Marcantonio E.E. (J. Biol. Chem. 1993)
    2. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    3. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    6. Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. (PubMed id 18454440)1, 4 Laurin N....Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PubMed id 18081024)1, 4 Laurin N....Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    8. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral density and fracture risk in postmenopausal Koreans. (PubMed id 17931993)1, 4 Lee H.J....Lee J.Y. (Bone 2007)
    9. Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP. (PubMed id 15592458)1, 2 Mattila E....Ivaska J. (Nat. Cell Biol. 2005)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3672 HGNC: 6134 AceView: PELO Ensembl:ENSG00000213949 euGenes: HUgn3672
    ECgene: ITGA1 Kegg: 3672 H-InvDB: ITGA1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITGA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ITGA1 gene:
    Search GeneIP for patents involving ITGA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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