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Aliases for ITGA1 Gene

Aliases for ITGA1 Gene

  • Integrin, Alpha 1 2 3
  • CD49 Antigen-Like Family Member A 3 4
  • Laminin And Collagen Receptor 3 4
  • VLA-1 3 4
  • VLA1 3 6
  • Very Late Activation Protein 1 3
  • Integrin Alpha-1 3
  • CD49a Antigen 4
  • CD49a 3

External Ids for ITGA1 Gene

Previous GeneCards Identifiers for ITGA1 Gene

  • GC05P052249
  • GC05U900017
  • GC05P052099
  • GC05P052119
  • GC05P052083
  • GC05P049056

Summaries for ITGA1 Gene

Entrez Gene Summary for ITGA1 Gene

  • This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

GeneCards Summary for ITGA1 Gene

ITGA1 (Integrin, Alpha 1) is a Protein Coding gene. Diseases associated with ITGA1 include colon carcinoma in situ and phimosis. Among its related pathways are PI3K-Akt signaling pathway and Regulation of actin cytoskeleton. GO annotations related to this gene include protein heterodimerization activity and protein phosphatase binding. An important paralog of this gene is ITGA8.

UniProtKB/Swiss-Prot for ITGA1 Gene

  • Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

Tocris Summary for ITGA1 Gene

  • Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin, -vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have a significant role in cell signaling and can activate protein kinases involved in the regulation of cell growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITGA1 Gene

Genomics for ITGA1 Gene

Regulatory Elements for ITGA1 Gene

Genomic Location for ITGA1 Gene

Start:
52,787,896 bp from pter
End:
52,959,210 bp from pter
Size:
171,315 bases
Orientation:
Plus strand

Genomic View for ITGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITGA1 Gene

Proteins for ITGA1 Gene

  • Protein details for ITGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56199-ITA1_HUMAN
    Recommended name:
    Integrin alpha-1
    Protein Accession:
    P56199
    Secondary Accessions:
    • B2RNU0

    Protein attributes for ITGA1 Gene

    Size:
    1179 amino acids
    Molecular mass:
    130848 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21. Interacts (via cytoplasmic domain) with PTPN2; activates PTPN2 phosphatase activity towards EGFR and negatively regulates EGF signaling.

    Three dimensional structures from OCA and Proteopedia for ITGA1 Gene

neXtProt entry for ITGA1 Gene

Proteomics data for ITGA1 Gene at MOPED

Post-translational modifications for ITGA1 Gene

  • Glycosylation at Asn74, Asn100, Asn105, Asn112, Asn217, Asn317, Asn341, Asn402, Asn418, Asn460, Asn532, Asn699, Asn748, Asn780, Asn840, Asn883, Asn908, Asn915, Asn939, Asn966, Asn974, Asn1008, Asn1073, Asn1083, Asn1102, and Asn1113
  • Modification sites at PhosphoSitePlus

Other Protein References for ITGA1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ITGA1 Gene

Domains for ITGA1 Gene

Gene Families for ITGA1 Gene

HGNC:
  • CD :CD molecules
  • ITG :Integrins

Suggested Antigen Peptide Sequences for ITGA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56199

UniProtKB/Swiss-Prot:

ITA1_HUMAN :
  • P56199
Domain:
  • The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
  • Contains 1 VWFA domain.
Family:
  • Belongs to the integrin alpha chain family.
Similarity:
  • Contains 7 FG-GAP repeats.
genes like me logo Genes that share domains with ITGA1: view

Function for ITGA1 Gene

Molecular function for ITGA1 Gene

GENATLAS Biochemistry: integrin,alpha 1,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells,dimerizing with ITGB1 in collagen,laminin receptors
UniProtKB/Swiss-Prot Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

Gene Ontology (GO) - Molecular Function for ITGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 16754661
GO:0005518 collagen binding TAS 8428973
GO:0019903 protein phosphatase binding IPI 15592458
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ITGA1: view
genes like me logo Genes that share phenotypes with ITGA1: view

Animal Models for ITGA1 Gene

MGI Knock Outs for ITGA1:

miRNA for ITGA1 Gene

miRTarBase miRNAs that target ITGA1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ITGA1 Gene

Localization for ITGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITGA1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITGA1 Gene COMPARTMENTS Subcellular localization image for ITGA1 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ITGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane TAS --
GO:0005925 focal adhesion IDA 11518510
GO:0008305 integrin complex TAS 8428973
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ITGA1: view

Pathways for ITGA1 Gene

genes like me logo Genes that share pathways with ITGA1: view

Gene Ontology (GO) - Biological Process for ITGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0006936 muscle contraction TAS --
GO:0007155 cell adhesion --
GO:0007160 cell-matrix adhesion IMP 24823363
GO:0007229 integrin-mediated signaling pathway IEA --
genes like me logo Genes that share ontologies with ITGA1: view

Compounds for ITGA1 Gene

(5) Tocris Compounds for ITGA1 Gene

Compound Action Cas Number
BIO 1211 Selective alpha4beta1 (VLA-4) inhibitor [187735-94-0]
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 [327613-57-0]
Eptifibatide Glycoprotein IIb/IIIa inhibitor; inhibits platelet aggregation [188627-80-7]
Obtustatin Potent and selective alpha1beta1 inhibitor
TC-I 15 Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo [916734-43-5]

(9) Novoseek inferred chemical compound relationships for ITGA1 Gene

Compound -log(P) Hits PubMed IDs
matrigel 37.5 1
wortmannin 8.49 1
magnesium 0 2
lysine 0 1
oxygen 0 1
genes like me logo Genes that share compounds with ITGA1: view

Transcripts for ITGA1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ITGA1 Gene

No ASD Table

Relevant External Links for ITGA1 Gene

GeneLoc Exon Structure for
ITGA1
ECgene alternative splicing isoforms for
ITGA1

Expression for ITGA1 Gene

mRNA expression in normal human tissues for ITGA1 Gene

mRNA differential expression in normal tissues according to GTEx for ITGA1 Gene

This gene is overexpressed in Esophagus - Muscularis (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITGA1 Gene

genes like me logo Genes that share expressions with ITGA1: view

No data available for mRNA Expression by UniProt/SwissProt for ITGA1 Gene

Orthologs for ITGA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITGA1 35
  • 99.72 (n)
  • 99.58 (a)
ITGA1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITGA1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITGA1 35
  • 91.51 (n)
  • 92.19 (a)
ITGA1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itga1 35
  • 84.75 (n)
  • 88.03 (a)
Itga1 16
Itga1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITGA1 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITGA1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itga1 35
  • 85.09 (n)
  • 87.86 (a)
chicken
(Gallus gallus)
Aves ITGA1 35
  • 72.2 (n)
  • 70.85 (a)
ITGA1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITGA1 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24376 35
tropical clawed frog
(Silurana tropicalis)
Amphibia itga1 35
  • 65.66 (n)
  • 63.17 (a)
Str.15516 35
zebrafish
(Danio rerio)
Actinopterygii itga1 35
  • 59.21 (n)
  • 54.76 (a)
itga1 36
  • 52 (a)
OneToOne
zgc56550 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for ITGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITGA1 Gene

ENSEMBL:
Gene Tree for ITGA1 (if available)
TreeFam:
Gene Tree for ITGA1 (if available)

Paralogs for ITGA1 Gene

Selected SIMAP similar genes for ITGA1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ITGA1: view

Variants for ITGA1 Gene

Sequence variations from dbSNP and Humsavar for ITGA1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs870992 -- 52,897,406(-) TTTCA(C/T)GCACT intron-variant
rs877651 -- 52,814,658(-) CAGGA(A/G)CTTAT intron-variant
rs889294 -- 52,814,842(+) TTTCA(A/G)CCAGG intron-variant
rs889295 -- 52,814,876(+) TCACG(A/G)AAGTA intron-variant
rs889296 -- 52,816,786(+) ACTCC(A/G)CTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITGA1 Gene

Variant ID Type Subtype PubMed ID
nsv462187 CNV Gain 19166990
nsv471013 CNV Gain 18288195
nsv830295 CNV Gain 17160897
esv2475081 CNV Loss 19546169
esv2730174 CNV Deletion 23290073
esv1295358 CNV Deletion 17803354
nsv830296 CNV Gain 17160897
esv2590093 CNV Deletion 19546169
esv2730175 CNV Deletion 23290073
esv2399032 CNV Deletion 18987734
esv2730176 CNV Deletion 23290073
esv3407 CNV Deletion 18987735
dgv197n6 CNV Loss 16902084
esv1002775 CNV Deletion 20482838
esv8218 CNV Loss 19470904
esv1167986 CNV Deletion 17803354

Relevant External Links for ITGA1 Gene

HapMap Linkage Disequilibrium report
ITGA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITGA1 Gene

Disorders for ITGA1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ITGA1 Gene including...

Search for ITGA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ITGA1 Gene

(12) Novoseek inferred disease relationships for ITGA1 Gene

Disease -log(P) Hits PubMed IDs
preeclampsia 17.7 1
tumors 17.5 6
metastasis 16 4
necrosis 14.1 1
hepatocellular carcinoma 12.9 2

Relevant External Links for ITGA1

Genetic Association Database (GAD)
ITGA1
Human Genome Epidemiology (HuGE) Navigator
ITGA1
genes like me logo Genes that share disorders with ITGA1: view

No data available for UniProtKB/Swiss-Prot for ITGA1 Gene

Publications for ITGA1 Gene

  1. Expression of native and truncated forms of the human integrin alpha 1 subunit. (PMID: 8428973) Briesewitz R. … Marcantonio E.E. (J. Biol. Chem. 1993) 2 3 4 23
  2. Evidence of T-cell activation and potential cytokine action in human endometrium. (PMID: 2144294) Tabibzadeh S. (J. Clin. Endocrinol. Metab. 1990) 3 23
  3. Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells. (PMID: 2169872) Tawil N.J. … Carbonetto S. (Biochemistry 1990) 3 23
  4. Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine. (PMID: 2341567) MacDonald T.T. … Richman P.I. (J. Clin. Pathol. 1990) 3 23
  5. alpha1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteins. (PMID: 11336656) LAPster K. … Danker K. (Biochem. J. 2001) 3 23

Products for ITGA1 Gene

Sources for ITGA1 Gene

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