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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ITGA1 Gene

protein-coding   GIFtS: 62
GCID: GC05P052083

Integrin, Alpha 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Integrin, Alpha 11 2     CD49a2
Laminin And Collagen Receptor2 3     Integrin Alpha-12
VLA-12 3     Very Late Activation Protein 12
CD49 Antigen-Like Family Member A2 3     CD49a Antigen3
VLA12 5     

External Ids:    HGNC: 61341   Entrez Gene: 36722   Ensembl: ENSG000002139497   OMIM: 1929685   UniProtKB: P561993   

Export aliases for ITGA1 gene to outside databases

Previous GC identifers: GC05P052249 GC05U900017 GC05P052099 GC05P052119 GC05P049056


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ITGA1 Gene:
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit
to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell
adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von
Willebrand factor type I domain which is thought to be involved in collagen binding. (provided by RefSeq, Jul
2008)

GeneCards Summary for ITGA1 Gene: 
ITGA1 (integrin, alpha 1) is a protein-coding gene. Diseases associated with ITGA1 include colon carcinoma in situ, and phimosis, and among its related super-pathways are Integrin-mediated cell adhesion and Hypertrophic cardiomyopathy (HCM). GO annotations related to this gene include collagen binding and protein heterodimerization activity. An important paralog of this gene is ITGA6.

UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated
sequence G-F-P-G-E-R in collagen

summary for ITGA1 Gene:
Integrins are ubiquitously expressed adhesion molecules. They are cell-surface receptors that exist as
heterodimers of alpha and beta subunits. At physiological conditions, integrins are highly glycosylated and
contain a Ca2+ or Mg2+ ion, which is essential for ligand binding. Integrin receptors are critical for cell
attachment to the extracellular matrix (ECM) and this is mediated through integrin-fibronectin,
-vitronectin, -collagen and -laminin interactions. Intracellularly, integrins form adhesion complexes with
proteins including talin, vinculin, paxillin and alpha-actinin. They also regulate kinases, such as focal
adhesion kinase and Src family kinases, to mediate attachment to the actin cytoskeleton. Integrins also have
a significant role in cell signaling and can activate protein kinases involved in the regulation of cell
growth, division, survival, differentiation, migration and apoptosis. Glycoprotein II/IIIb (alphaIIbeta3) is
an integrin receptor found on the surface of platelets. It is involved in the cross-linking of platelets
with fibrin, and so has a vital role in blood clot formation.

Gene Wiki entry for ITGA1 (CD49a) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ITGA1 gene promoter:
         Oct-B1   SRF   oct-B3   oct-B2   AP-1   SRF (504 AA)   POU2F2   Evi-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITGA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ITGA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITGA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.1

ITGA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITGA1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P052083:  view genomic region     (about GC identifiers)

Start:
52,083,730 bp from pter      End:
52,255,040 bp from pter
Size:
171,311 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199 (See protein sequence)
Recommended Name: Integrin alpha-1 precursor  
Size: 1179 amino acids; 130848 Da
Subunit: Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21
Subcellular location: Membrane; Single-pass type I membrane protein
5 PDB 3D structures from and Proteopedia for ITGA1:
1PT6 (3D)        1QC5 (3D)        1QCY (3D)        2L8S (3D)        4A0Q (3D)    
Secondary accessions: B2RNU0

Explore the universe of human proteins at neXtProt for ITGA1: NX_P56199

Explore proteomics data for ITGA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56199

  • ITGA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ITGA1 Protein Expression
    REFSEQ proteins: NP_852478.1  
    ENSEMBL proteins: 
     ENSP00000282588  
    Reactome Protein details: P56199
    Human Recombinant Protein Products for ITGA1: 
    EMD Millipore Purified and/or Recombinant ITGA1 Protein
    R&D Systems Recombinant & Natural Proteins for ITGA1 (Integrin alpha 1 beta 1)
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    GenScript Custom Purified and Recombinant Proteins Services for ITGA1
    Novus Biologicals ITGA1 Proteins
    Novus Biologicals ITGA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001669acrosomal vesicle IEA--
    GO:0005886plasma membrane TAS--
    GO:0008305integrin complex TAS8428973
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----

    ITGA1 for ontologies           About GeneDecksing



    ITGA1 Antibody Products: 
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    Assay Products for ITGA1: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ITG: Integrins

    5/6 InterPro protein domains (see all 6):
     IPR000413 Integrin_alpha
     IPR018184 Integrin_alpha_C_CS
     IPR013649 Integrin_alpha-2
     IPR013519 Int_alpha_beta-p
     IPR013517 FG-GAP

    Graphical View of Domain Structure for InterPro Entry P56199

    ProtoNet protein and cluster: P56199

    4 Blocks protein domains:
    IPB000413 Integrins alpha chain
    IPB002035 Von Willebrand factor type A domain signature
    IPB013513 Integrin alpha chain
    IPB013517 FG-GAP


    UniProtKB/Swiss-Prot: ITA1_HUMAN, P56199
    Domain: The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage
    Similarity: Belongs to the integrin alpha chain family
    Similarity: Contains 7 FG-GAP repeats
    Similarity: Contains 1 VWFA domain


    ITGA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ITA1_HUMAN, P56199
    Function: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated
    sequence G-F-P-G-E-R in collagen

         Genatlas biochemistry entry for ITGA1:
    integrin,alpha 1,cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other
    cells,through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within
    cells,dimerizing with ITGB1 in collagen,laminin receptors

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI16754661
    GO:0005518collagen binding TAS8428973
    GO:0019903protein phosphatase binding IPI15592458
    GO:0046872metal ion binding IEA--
         
    ITGA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ITGA1:
     Elongated cells 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itga1):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  immune system 
     mortality/aging  renal/urinary system 

    ITGA1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Itga1tm1Gdnr for ITGA1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ITGA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ITGA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ITGA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ITGA1 

    miRNA
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    hsa-miR-3163 hsa-miR-3679-5p hsa-miR-3065-5p hsa-miR-578 hsa-miR-1185 hsa-miR-1304 hsa-miR-544b hsa-miR-3134
    SwitchGear 3'UTR luciferase reporter plasmidITGA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ITGA1
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ITGA1

    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of ITGA1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ITGA1 About   (see all 36)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Focal Adhesion
    Focal adhesion0.64
    HGF Pathway0.34
    Integrin-mediated cell adhesion0.38
    2Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.53
    3Regulation of Actin Cytoskeleton
    Regulation of Actin Cytoskeleton0.57
    Regulation of actin cytoskeleton0.57
    4Non-integrin membrane-ECM interactions
    ECM-receptor interaction0.42
    Integrin cell surface interactions0.32
    5Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Transendothelial Migration of Leukocytes0.38
    GnRH Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for ITGA1
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling
    Cell adhesion Endothelial cell contacts by non-junctional mechanisms

    5/33 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ITGA1 (see all 33)
        RhoA Pathway
    Paxillin Interactions
    Molecular Mechanisms of Cancer
    CDK5 Pathway
    Tec Kinases Signaling

    4 GeneGo (Thomson Reuters) Pathways for ITGA1
        Cell adhesion Endothelial cell contacts by non-junctional mechanisms
    Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Integrin inside-out signaling
    Cell adhesion ECM remodeling

    5/9 BioSystems Pathways for ITGA1 (see all 9)
        Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    Arrhythmogenic right ventricular cardiomyopathy
    VEGFR3 signaling in lymphatic endothelium
    CXCR4-mediated signaling events


    5/10        Reactome Pathways for ITGA1 (see all 10)
        L1CAM interactions
    Developmental Biology
    Integrin cell surface interactions
    Smooth Muscle Contraction
    Other semaphorin interactions


    5/8         Kegg Pathways  (Kegg details for ITGA1) (see all 8):
        PI3K-Akt signaling pathway
    Focal adhesion
    ECM-receptor interaction
    Hematopoietic cell lineage
    Regulation of actin cytoskeleton


    ITGA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ITGA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/135 Interacting proteins for ITGA1 (P561992, 3 ENSP000002825884) via UniProtKB, MINT, STRING, and/or I2D (see all 135)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN2P177062, 3, ENSP000003118574MINT-8284727 MINT-8284737 I2D: score=1 STRING: ENSP00000311857
    BIN1O004993, ENSP000003167794I2D: score=2 STRING: ENSP00000316779
    LAMA1P253913, ENSP000003743094I2D: score=2 STRING: ENSP00000374309
    TLN1Q9Y4903, ENSP000003160294I2D: score=2 STRING: ENSP00000316029
    COL8A1P276583, ENSP000002610374I2D: score=1 STRING: ENSP00000261037
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IEA--
    GO:0006936muscle contraction TAS--
    GO:0007155cell adhesion ----
    GO:0007160cell-matrix adhesion NAS--
    GO:0007229integrin-mediated signaling pathway IEA--

    ITGA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ITGA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ITGA1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    TC-I 15Potent alpha2beta1 inhibitor; displays antithrombotic activity in vivo[916734-43-5]
    BIO 1211Selective alpha4beta1 (VLA-4) inhibitor[187735-94-0]
    Leukadherin 1Allosteric activator of CD11b/CD18[344897-95-6]
    A 286982Potent inhibitor of the LFA-1/ICAM-1 interaction[280749-17-9]
    ObtustatinPotent and selective alpha1beta1 inhibitor--

    9 Novoseek inferred chemical compound relationships for ITGA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 37.5 1 18775695 (1)
    wortmannin 8.49 1 16289050 (1)
    magnesium 0 2 2380249 (1), 10457223 (1)
    lysine 0 1 11336656 (1)
    oxygen 0 1 16807282 (1)
    progesterone 0 2 9009235 (1)
    tyrosine 0 2 11336656 (1), 16472776 (1)
    estrogen 0 1 19780039 (1)
    dexamethasone 0 1 9618153 (1)

    Search CenterWatch for drugs/clinical trials and news about ITGA1 / ITA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ITGA1 gene: 
    NM_181501.1  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282588(uc003jou.3 uc003jov.3) ENST00000504086 ENST00000514262
    ENST00000513737 ENST00000509049 ENST00000504669(uc003jow.3) ENST00000506275


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    24/542 AceView cDNA sequences (see all 542):

    AA575956 BQ056764 BE550369 AI696364 BX641792 AI127795 BX400814 CA772057 
    AI074570 BG619261 NM_015946 BQ062149 BQ890439 CR614560 BQ063271 CR611502 
    CR598853 BQ059596 BQ058833 CR619811 AI401237 CR610567 AL709969 BQ065724 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ITGA1 expression in normal human tissues (normalized intensities)      ITGA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ITGA1 Expression
    About this image


    ITGA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 10 entries
             Bone Marrow Stromal Cells Bone Marrow
             TGFbeta3+BMP7-induced chondrocytes
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Bone Marrow Stromal Cells Bone Marrow
             TGFbeta3+BMP7-induced chondrocytes
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Stylopod
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Non-myelinating Schwann Cells Peripheral Nerve Domain
             Human Perineurial Cells (HPC)   
     
     Smooth Muscle (Muscoskeletal System)
             Human Colonic Smooth Muscle Cells (HCoSMC)   

    See ITGA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ITGA1
        SABiosciences Expression via Pathway-Focused PCR Arrays including ITGA1 (see all 8): 
              Osteogenesis in human mouse rat
              Fibrosis in human mouse rat
              Extracellular Matrix & Adhesion Molecules in human mouse rat
              Cell Surface Markers in human mouse rat
              Wound Healing in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITGA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ITGA1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itga11 , 5 integrin alpha 11, 5 84.75(n)1
    88.03(a)1
      13 (64.61 cM)5
    1097001  NM_001033228.31  NP_001028400.21 
     1149580795 
    chicken
    (Gallus gallus)
    Aves ITGA11 integrin, alpha 1 72.2(n)
    70.85(a)
      395951  NM_205069.1  NP_990400.1 
    lizard
    (Anolis carolinensis)
    Reptilia ITGA16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    2(3643435-3686438)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243762 Xenopus laevis transcribed sequence with moderate similarity more 75.71(n)    48020794 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565502 similar to pelota homolog (Drosophila) 76.56(n)   394111  BC049484.1 


    ENSEMBL Gene Tree for ITGA1 (if available)
    TreeFam Gene Tree for ITGA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ITGA1 gene
    ITGA62  ITGA32  ITGA72  ITGA82  ITGAM2  ITGA112  ITGA22  ITGA52  
    ITGAE2  ITGAD2  ITGA2B2  ITGAV2  ITGAX2  ITGAL2  ITGA92  ITGA102  
    ITGA42  
    4 SIMAP similar genes for ITGA1 using alignment to 1 protein entry:     ITA1_HUMAN:
    ITGA2    ITGA11    ITGA10    COL21A1

    ITGA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3332 SNPs in ITGA1 are shown (see all 3332)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407790341,2
    Cuntested152216207(+) ATCACG/AAAGTT 2 /Q /R mis11Minor allele frequency- A:0.00NA 4538
    rs1420655401,2
    --52098978(+) CTGTGA/GGCCTT 1 -- int10--------
    rs1130372501,2
    C,F--52099080(+) ACTTTG/AAAACT 1 -- int11Minor allele frequency- A:0.50WA 2
    rs11571371,2
    C--52099093(+) CATATT/GTATAT 1 -- int112Minor allele frequency- G:0.10MN NA WA CSA EA 555
    rs92919941,2
    C,F--52099095(+) TATGTA/TTATTT 1 -- int11Minor allele frequency- T:0.03WA 118
    rs709744721,2
    C--52099160(+) TCCGT-/GAGT  
            
    ATCTT
    1 -- int11Minor allele frequency- GAGT:0.00NA 2
    rs92919951,2
    C,F,H--52099436(+) GCAGCC/TCAGAC 1 -- int114Minor allele frequency- T:0.14NS EA NA WA CSA 784
    rs1882541171,2
    --52099453(+) AATAAC/TGTTTT 1 -- int10--------
    rs623584441,2
    C--52099482(+) TTTAAA/GGCTAC 1 -- int14Minor allele frequency- G:0.22NA WA EA 360
    rs1914976781,2
    --52099632(+) ACAGGC/TGCTAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for ITGA1 (52083730 - 52255040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for ITGA1 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730175CNV Deletion23290073
    esv2730174CNV Deletion23290073
    esv2730176CNV Deletion23290073
    esv2399032CNV Deletion18987734
    esv2590093CNV Deletion19546169
    esv1295358CNV Deletion17803354
    esv3407CNV Deletion18987735
    esv1167986CNV Deletion17803354
    esv1002775CNV Deletion20482838
    dgv197n6CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 192968    OMIM disorders: --

    20/46 diseases for ITGA1 (see all 46):    About MalaCards
    colon carcinoma in situ    phimosis    gilles de la tourette syndrome    brain ischemia
    mycosis fungoides    eosinophilia    attention deficit hyperactivity disorder    cervical cancer
    endometrial adenocarcinoma    polycystic kidney disease    tonsillitis    kidney disease
    influenza    psoriasis    peripheral neuropathy    scleroderma
    hypertrophic cardiomyopathy    sarcoidosis    eclampsia    pre-eclampsia

    1 disease from the University of Copenhagen DISEASES database for ITGA1:
    Colon carcinoma in situ

    ITGA1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/12 Novoseek inferred disease relationships for ITGA1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    preeclampsia 17.7 1 9403732 (1)
    tumors 17.5 9 17982677 (1), 1711920 (1), 8864174 (1), 18579572 (1) (see all 6)
    metastasis 16 4 8105045 (3), 15679046 (1)
    necrosis 14.1 1 1869591 (1)
    hepatocellular carcinoma 12.9 2 9824613 (2)
    psoriasis 6.81 4 18269595 (3), 17603494 (1)
    breast carcinoma 0 1 1711920 (1)
    cervical cancer 0 1 7573248 (1)
    colitis 0 2 2341567 (2)
    influenza 0 3 17372009 (2)

    Genetic Association Database (GAD): ITGA1
    Human Genome Epidemiology (HuGE) Navigator: ITGA1 (11 documents)

    Export disorders for ITGA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ITGA1 gene, integrated from 9 sources (see all 217):
    (articles sorted by number of sources associating them with ITGA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of native and truncated forms of the human integrin alpha 1 subunit. (PubMed id 8428973)1, 2, 3, 9 Briesewitz R.... Marcantonio E.E. (1993)
    2. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (2011)
    3. Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (2011)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    6. Association study for genes at chromosome 5p13-q11 in attention deficit hyperactivity disorder. (PubMed id 18081024)1, 4 Laurin N....Barr C.L. (2008)
    7. Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. (PubMed id 18454440)1, 4 Laurin N....Barr C.L. (2008)
    8. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral density and fracture risk in postmenopausal Koreans. (PubMed id 17931993)1, 4 Lee H.J....Lee J.Y. (2007)
    9. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    10. Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1. (PubMed id 14660600)1, 2 Nymalm Y....Salminen T.A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3672 HGNC: 6134 AceView: PELO Ensembl:ENSG00000213949 euGenes: HUgn3672
    ECgene: ITGA1 Kegg: 3672 H-InvDB: ITGA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ITGA1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ITGA1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ITGA1 gene:
    Search GeneIP for patents involving ITGA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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