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ITFG2 Gene

protein-coding   GIFtS: 45
GCID: GC12P002921

Integrin Alpha FG-GAP Repeat Containing 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5.2

Aliases
Integrin Alpha FG-GAP Repeat Containing 21 2
MDS0282
Integrin-Alpha FG-GAP Repeat-Containing Protein 22

External Ids:    HGNC: 308791   Entrez Gene: 558462   Ensembl: ENSG000001112037   UniProtKB: Q969R83   
ORGUL members:    fRNAdb10:FR255273 FR144657      
NCBI13:U90917    
NONCODE14:n411109    
RNAdb15:ASO2274 RNZ8256    

Export aliases for ITFG2 gene to outside databases

Previous GC identifer: GC12P002793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ITFG2 Gene:
ITFG2 (integrin alpha FG-GAP repeat containing 2) is a protein-coding gene.

fRNAdb sequence ontologies for ITFG2 - the ORGUL cluster for this gene includes several descriptions:
antisense_RNA - Antisense RNA is RNA that is transcribed from the coding, rather than the template, strand of DNA. It is therefore complementary to mRNA.
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for ITFG2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ITFG2 gene promoter:
         Bach1   SRF   AML1a   Sp1   Tal-1   SRF (504 AA)   E47   PPAR-gamma1   POU2F1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidITFG2 promoter sequence
   Search Chromatin IP Primers for ITFG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ITFG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.33   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.33

ITFG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ITFG2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P002921:  view genomic region     (about GC identifiers)

Start:
2,921,787 bp from pter      End:
2,968,957 bp from pter
Size:
47,171 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ITFG2_HUMAN, Q969R8 (See protein sequence)
Recommended Name: Integrin-alpha FG-GAP repeat-containing protein 2  
Size: 447 amino acids; 49313 Da
Secondary accessions: A8K4Z5 D3DUQ2 Q96SX6

Explore the universe of human proteins at neXtProt for ITFG2: NX_Q969R8

Explore proteomics data for ITFG2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ITFG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060933.3  
    ENSEMBL proteins: 
     ENSP00000228799   ENSP00000445769   ENSP00000443329   ENSP00000440015   ENSP00000439324  
     ENSP00000444331   ENSP00000442023   ENSP00000437870   ENSP00000401103  

    ITFG2 Human Recombinant Protein Products:

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    Novus Biologicals ITFG2 Protein
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ITFG2

     
    Search eBioscience for Proteins for ITFG2 

     
    antibodies-online proteins for ITFG2 (4 products) 

     
    antibodies-online peptides for ITFG2

    ITFG2 Antibody Products:

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    antibodies-online antibodies for ITFG2 (35 products) 

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    Cloud-Clone Corp. ELISAs for ITFG2
    Cloud-Clone Corp. CLIAs for ITFG2
    Search eBioscience for ELISAs for ITFG2 
    antibodies-online kits for ITFG2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013517 FG-GAP
     IPR017986 WD40_repeat_dom

    Graphical View of Domain Structure for InterPro Entry Q969R8

    ProtoNet protein and cluster: Q969R8

    UniProtKB/Swiss-Prot: ITFG2_HUMAN, Q969R8
    Similarity: Contains 2 FG-GAP repeats


    Find genes that share domains with ITFG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ITFG2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Itfg2):
     hematopoietic system  homeostasis/metabolism  immune system  renal/urinary system 

    Find genes that share phenotypes with ITFG2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ITFG2

    miRNA
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    Block miRNA regulation of human, mouse, rat ITFG2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ITFG2:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidITFG2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITFG2
    Predesigned siRNA for gene silencing in human, mouse, rat ITFG2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ITFG2 (NM_018463)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITFG2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITFG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ITFG2
    Interactions:

        Search GeneGlobe Interaction Network for ITFG2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ITFG2 (Q969R82, 3 ENSP000002287994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNK2Q079122, 3, ENSP000003713414MINT-64707 I2D: score=2 STRING: ENSP00000371341
    KPTNQ9Y6643, ENSP000003378504I2D: score=1 STRING: ENSP00000337850
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ITFG2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for ITFG2 gene: 
    NM_018463.3  

    Unigene Clusters for ITFG2:

    Integrin alpha FG-GAP repeat containing 2
    Hs.446098  [show with all ESTs], Hs.448720  [show with all ESTs]
    Unigene Representative Sequences: NM_018463, AK096262
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228799(uc001qlb.2 uc010seb.2) ENST00000543029(uc001qla.2)
    ENST00000537851 ENST00000540929 ENST00000541659 ENST00000535564 ENST00000537183
    ENST00000534935 ENST00000540662 ENST00000538822 ENST00000552005 ENST00000537710(uc021qtc.1)
    ENST00000540300 ENST00000545509 ENST00000542548(uc010sec.2) ENST00000419778

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate ITFG2:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidITFG2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ITFG2
    Predesigned siRNA for gene silencing in human, mouse, rat ITFG2
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    GenScript: all cDNA clones in your preferred vector: ITFG2 (NM_018463)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ITFG2
      QuantiTect SYBR Green Assays in human, mouse, rat ITFG2
      QuantiFast Probe-based Assays in human, mouse, rat ITFG2

    Additional mRNA sequence: 

    AF220048.1 AK096262.1 

    21 DOTS entries:

    DT.100779728  DT.100670977  DT.412064  DT.100699030  DT.100779723  DT.121115071  DT.121115276  DT.40211045 
    DT.95247791  DT.99935692  DT.100009690  DT.95069490  DT.95335903  DT.121115088  DT.95069491  DT.100763557 
    DT.100779725  DT.121115175  DT.121115189  DT.121115237  DT.91682130 

    Selected AceView cDNA sequences (see all 547):

    AA295208 BQ920081 BU196514 BQ059307 BQ059244 BQ772153 AW027226 CB121212 
    BU176390 CA417692 BC006552 CA495356 BQ689063 F34886 BI040197 BE336888 
    BM808780 BQ688593 BE794700 M88279 CF264689 AA394058 BF982262 BM461957 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ITFG2 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a ·
    SP1:                                                              -     -     -     -                                                                 -         
    SP2:                                                                                                                                                            
    SP3:                                      -     -     -     -     -     -     -     -                                                                           
    SP4:                                                                                                              -                                             
    SP5:                                                        -     -     -     -     -                                                                           

    ExUns: 13b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for ITFG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ITFG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAAGCCAGG
    ITFG2 Expression
    About this image

    ITFG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ITFG2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.446098 Hs.448720
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITFG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ITFG2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Itfg21 , 5 integrin alpha FG-GAP repeat containing 21, 5 87.13(n)1
    90.29(a)1
      6 (62.99 cM)5
    1011421  NM_133927.11  NP_598688.11 
     1284094445 
    chicken
    (Gallus gallus)
    Aves ITFG21 integrin alpha FG-GAP repeat containing 2 74.11(n)
    77.68(a)
      418262  XM_416486.4  XP_416486.2 
    lizard
    (Anolis carolinensis)
    Reptilia ITFG26
    integrin alpha FG-GAP repeat containing 2
    70(a)
    1 ↔ 1
    5(80606727-80628340)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia itfg21 integrin alpha FG-GAP repeat containing 2 67.3(n)
    68.87(a)
      100144985  NM_001126551.1  NP_001120023.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.177822 Transcribed sequence 80.28(n)    BQ092541.1 


    ENSEMBL Gene Tree for ITFG2 (if available)
    TreeFam Gene Tree for ITFG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ITFG2 gene

    Find genes that share paralogs with ITFG2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ITFG2
    PGOHUM00000235353


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ITFG2 (see all 387)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs772293781,2
    C--2920073(+) CTCACA/G/TCCTGT 1 -- us2k10--------
    rs1816374651,2
    C--2920201(+) CCGGGC/GGCCGG 1 -- us2k10--------
    rs71389571,2
    C--2920485(+) aaaaaT/Aaaaat 1 -- us2k1 tfbs3 trp31Minor allele frequency- A:0.50NA 2
    rs72971061,2
    C,A--2920491(+) aaaatA/Taaatt 1 -- us2k1 tfbs33Minor allele frequency- T:0.17NA 6
    rs1127945721,2
    C,F--2920496(+) TAAATA/TAAATT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs576502631,2
    C,F--2920501(+) TAAATA/TAAATT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs72971131,2
    C,F--2920506(+) taaatA/Taaaaa 1 -- us2k12Minor allele frequency- T:0.25NA 4
    rs563643671,2
    C,F--2920688(+) AAAAAT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs107740661,2
    C,F,A,H--2920736(+) TAAGGC/TAGAAT 1 -- us2k1 tfbs320Minor allele frequency- N:0.00NS EA NA 2202
    rs717552991,2
    C--2920744(+) AATCA-/T/TT  
            
    TTTTT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ITFG2 (2921787 - 2968957 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ITFG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832311CNV Loss17160897
    dgv19n68CNV Loss17160897
    nsv826194CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ITFG2
    DNA2.0 Custom Variant and Variant Library Synthesis for ITFG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM information: 602341    

    Find genes that share disorders with ITFG2           About GenesLikeMe


    Export disorders for ITFG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ITFG2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ITFG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    3. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M....Figeys D. (Mol. Syst. Biol. 2007)
    5. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. (PubMed id 15608161)10 
    9. (PubMed id 16273071)10 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55846 HGNC: 30879 AceView: FKBP4andMDS028 Ensembl:ENSG00000111203 euGenes: HUgn55846
    ECgene: ITFG2 H-InvDB: ITFG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ITFG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ITFG2 gene:
    Search GeneIP for patents involving ITFG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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