ITFG2 Gene
protein-coding GIFtS: 41
GCID: GC12P002921
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integrin alpha FG-GAP repeat containing 2
| |
Aliases
for ITFG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Integrin Alpha FG-GAP Repeat Containing 21 2 | | MDS0281 2 | | Integrin-Alpha FG-GAP Repeat-Containing Protein 22 |
Export aliases for ITFG2 gene to outside databasesPrevious GC identifer: GC12P002793 |
Summaries
for ITFG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ITFG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ITFG2 gene promoter:
Bach1 SRF AML1a Sp1 Tal-1 SRF (504 AA) E47 PPAR-gamma1 POU2F1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ITFG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITFG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.33 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33ITFG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P002921: view genomic region
(about GC identifiers)
Start:
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2,921,787 bp from pter |
End:
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2,968,957 bp from pter |
Size:
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47,171 bases |
Orientation:
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plus strand |
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Proteins
for ITFG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ITFG2_HUMAN, Q969R8 (See
protein sequence)Recommended Name: Integrin-alpha FG-GAP repeat-containing protein 2 Size: 447 amino acids; 49313 Da
Secondary accessions: A8K4Z5 D3DUQ2 Q96SX6Explore the universe of human proteins at neXtProt for ITFG2: NX_Q969R8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969R8
ITFG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060933.3
ENSEMBL proteins: ENSP00000228799 ENSP00000445769 ENSP00000443329 ENSP00000440015 ENSP00000439324 ENSP00000444331 ENSP00000442023 ENSP00000437870 ENSP00000401103
Human Recombinant Protein Products:
ITFG2 Antibody Products:
Assay Products for ITFG2: |
Protein
Domains /
Families
for ITFG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ITFG2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969R8ProtoNet protein and cluster: Q969R8 UniProtKB/Swiss-Prot: ITFG2_HUMAN, Q969R8Similarity: Contains 2 FG-GAP repeats |
Function
for ITFG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITFG2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITFG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ITFG2 (NM_018463) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITFG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITFG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITFG2 |
|
Pathways & Interactions
for ITFG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ITFG2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ITFG2 (Q969R82, 3 ENSP000002287994) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ITFG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ITFG2
Search CenterWatch for drugs/clinical trials and news about ITFG2
|
Transcripts
for ITFG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ITFG2 gene: NM_018463.3 Unigene Clusters for ITFG2: Integrin alpha FG-GAP repeat containing 2 Hs.446098 [show with all ESTs], Hs.448720 [show with all ESTs]Unigene Representative Sequences: NM_018463, AK09626216 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000228799(uc001qlb.2 uc010seb.2) ENST00000543029(uc001qla.2)
ENST00000537851 ENST00000540929 ENST00000541659 ENST00000535564 ENST00000537183
ENST00000534935 ENST00000540662 ENST00000538822 ENST00000552005 ENST00000537710(uc021qtc.1)
ENST00000540300 ENST00000545509 ENST00000542548(uc010sec.2) ENST00000419778
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITFG2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITFG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ITFG2 (NM_018463) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ITFG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITFG2 |
Additional cDNA sequence: AF220048.1 AK096262.1 21 DOTS entries: DT.100779728 DT.100670977 DT.412064 DT.100699030 DT.100779723 DT.121115071 DT.121115276 DT.40211045 DT.95247791 DT.99935692 DT.100009690 DT.95069490 DT.95335903 DT.121115088 DT.95069491 DT.100763557 DT.100779725 DT.121115175 DT.121115189 DT.121115237 DT.91682130 24/547 AceView cDNA sequences (see all 547): BM461957 BQ920081 BQ049735 AA219606 AA905094 BQ686589 BM450050 BQ575758 AA639661 BU542103 AY599883 BM457964 BU856857 AI761243 BC002887 BQ940104 BM684329 AA947923 AL121267 BU617601 BG676114 BQ061386 BQ882941 BU507709
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ITFG2 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 13b |
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| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | | |
| SP5: | | |
ECgene alternative splicing isoforms for ITFG2
|
Expression
for ITFG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ITFG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAAGCCAGG
About this image
See ITFG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ITFG2
SOURCE GeneReport for Unigene clusters: Hs.446098 Hs.448720
SABiosciences Custom PCR Arrays for ITFG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITFG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ITFG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITFG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITFG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITFG2 |
Orthologs
for ITFG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ITFG2 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for ITFG2 (if available)
TreeFam Gene Tree for ITFG2 (if available) |
Paralogs
for ITFG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ITFG2 gene
ITFG2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ITFG2
PGOHUM00000235353
|
Genomic Variants
for ITFG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ITFG2 (2921787 - 2968957 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ITFG2
1 CNV: 4766 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITFG2 |
|
Disorders
/ Diseases
for ITFG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ITFG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ITFG2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ITFG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for ITFG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ITFG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ITFG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ITFG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ITFG2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ITFG2 gene:
Search GeneIP for patents involving ITFG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ITFG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ITFG2 | | OriGene shRNA RFP for ITFG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ITFG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ITFG2 | | | OriGene Protein Over-expression Lysate for ITFG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ITFG2 | | OriGene 3'-UTR Clone for ITFG2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ITFG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ITFG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ITFG2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ITFG2 | | OriGene Custom Protein Services for ITFG2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ITFG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ITFG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ITFG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ITFG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ITFG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ITFG2 |
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 |  |  |  | |
| | | | Search Tocris compounds for ITFG2 |
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 | | | ITFG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ITFG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ITFG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ITFG2 |
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