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Aliases for ITFG2 Gene

Aliases for ITFG2 Gene

  • Integrin Alpha FG-GAP Repeat Containing 2 2 3
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 2 3
  • MDS028 3

External Ids for ITFG2 Gene

Previous GeneCards Identifiers for ITFG2 Gene

  • GC12P002793
  • GC12P002921

Summaries for ITFG2 Gene

GeneCards Summary for ITFG2 Gene

ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG2 Gene

Genomics for ITFG2 Gene

Regulatory Elements for ITFG2 Gene

Genomic Location for ITFG2 Gene

Start:
2,812,621 bp from pter
End:
2,859,791 bp from pter
Size:
47,171 bases
Orientation:
Plus strand

Genomic View for ITFG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ITFG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG2 Gene

Proteins for ITFG2 Gene

  • Protein details for ITFG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969R8-ITFG2_HUMAN
    Recommended name:
    Integrin-alpha FG-GAP repeat-containing protein 2
    Protein Accession:
    Q969R8
    Secondary Accessions:
    • A8K4Z5
    • D3DUQ2
    • Q6PKU5
    • Q96SX6

    Protein attributes for ITFG2 Gene

    Size:
    447 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITFG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITFG2 Gene

Proteomics data for ITFG2 Gene at MOPED

Post-translational modifications for ITFG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITFG2 Gene

No data available for DME Specific Peptides for ITFG2 Gene

Domains for ITFG2 Gene

Protein Domains for ITFG2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ITFG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969R8

UniProtKB/Swiss-Prot:

ITFG2_HUMAN :
  • Q969R8
Similarity:
  • Contains 2 FG-GAP repeats.
genes like me logo Genes that share domains with ITFG2: view

No data available for Gene Families for ITFG2 Gene

Function for ITFG2 Gene

Gene Ontology (GO) - Molecular Function for ITFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ITFG2: view
genes like me logo Genes that share phenotypes with ITFG2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ITFG2 Gene

Localization for ITFG2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITFG2 Gene COMPARTMENTS Subcellular localization image for ITFG2 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with ITFG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITFG2 Gene

Pathways for ITFG2 Gene

SuperPathways for ITFG2 Gene

No Data Available

Interacting Proteins for ITFG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000228799%0d%0a9606.ENSP00000337850%0d%0a
Selected Interacting proteins: Q969R8-ITFG2_HUMAN ENSP00000228799 for ITFG2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ITFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002314 germinal center B cell differentiation IEA --
genes like me logo Genes that share ontologies with ITFG2: view

No data available for Pathways by source for ITFG2 Gene

Transcripts for ITFG2 Gene

Unigene Clusters for ITFG2 Gene

Integrin alpha FG-GAP repeat containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ITFG2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a ·
SP1: - - - - -
SP2:
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7:
SP8:
SP9:

ExUns: 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ITFG2 Gene

GeneLoc Exon Structure for
ITFG2
ECgene alternative splicing isoforms for
ITFG2

Expression for ITFG2 Gene

mRNA expression in normal human tissues for ITFG2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ITFG2 Gene

SOURCE GeneReport for Unigene cluster for ITFG2 Gene Hs.446098

genes like me logo Genes that share expressions with ITFG2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ITFG2 Gene

Orthologs for ITFG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITFG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITFG2 35
  • 98.73 (n)
  • 99.11 (a)
ITFG2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ITFG2 35
  • 84.05 (n)
  • 85.14 (a)
ITFG2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITFG2 35
  • 87.76 (n)
  • 89.19 (a)
ITFG2 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itfg2 35
  • 87.13 (n)
  • 90.29 (a)
Itfg2 16
Itfg2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ITFG2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Itfg2 35
  • 87.72 (n)
  • 91.71 (a)
chicken
(Gallus gallus)
Aves ITFG2 35
  • 74.11 (n)
  • 77.68 (a)
ITFG2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITFG2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg2 35
  • 67.3 (n)
  • 68.87 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17782 35
itfg2 35
  • 68.86 (n)
  • 71.36 (a)
itfg2 36
  • 69 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1115 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2280 36
  • 38 (a)
OneToOne
Species with no ortholog for ITFG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITFG2 Gene

ENSEMBL:
Gene Tree for ITFG2 (if available)
TreeFam:
Gene Tree for ITFG2 (if available)

Paralogs for ITFG2 Gene

Pseudogenes.org Pseudogenes for ITFG2 Gene

genes like me logo Genes that share paralogs with ITFG2: view

No data available for Paralogs for ITFG2 Gene

Variants for ITFG2 Gene

Sequence variations from dbSNP and Humsavar for ITFG2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2109109 -- 2,823,891(-) AGCAG(C/T)TTCAC reference, synonymous-codon, nc-transcript-variant
rs2286601 -- 2,823,011(-) GGATA(C/T)GTCAG intron-variant
rs2286602 -- 2,821,103(-) ACAGG(C/G)ATGGG intron-variant
rs2286603 -- 2,817,390(-) TGTGG(G/T)GCTCA intron-variant
rs2286604 -- 2,817,377(-) CTAGG(C/T)GGTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITFG2 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV Loss 17160897
nsv826194 CNV Gain 20364138
nsv832311 CNV Loss 17160897

Relevant External Links for ITFG2 Gene

HapMap Linkage Disequilibrium report
ITFG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITFG2 Gene

Disorders for ITFG2 Gene

No disorders were found for ITFG2 Gene.

No data available for UniProtKB/Swiss-Prot for ITFG2 Gene

Publications for ITFG2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  3. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for ITFG2 Gene

Sources for ITFG2 Gene

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