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Aliases for ITFG2 Gene

Aliases for ITFG2 Gene

  • Integrin Alpha FG-GAP Repeat Containing 2 2 3 5
  • FG-GAP Repeat Containing 1 2 3
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 2 3
  • MDS028 3
  • FGGAP1 3

External Ids for ITFG2 Gene

Previous HGNC Symbols for ITFG2 Gene

  • FGGAP1

Previous GeneCards Identifiers for ITFG2 Gene

  • GC12P002793
  • GC12P002921

Summaries for ITFG2 Gene

GeneCards Summary for ITFG2 Gene

ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG2 Gene

Genomics for ITFG2 Gene

Regulatory Elements for ITFG2 Gene

Enhancers for ITFG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G001924 1.3 ENCODE dbSUPER 77.9 -887.8 -887811 0.8 ZNF133 FEZF1 GLI4 ZNF121 ZNF302 ZNF416 ZNF548 ZNF263 YY2 TSHZ1 ITFG2 DCP1B LRTM2 CACNA2D4 GC12M001928
GH12G002145 1 dbSUPER 79.2 -666.3 -666291 1.8 ZNF133 ZNF493 GLI4 FEZF1 TCF12 ZNF121 ZNF302 ZNF416 ZNF202 YY2 ITFG2 CBX3P4 IQSEC3P1 DCP1B CACNA1C-AS4 PIR59469 GC12P002105
GH12G002256 1.2 ENCODE dbSUPER 54.6 -555.9 -555923 1.6 ZNF133 GLI4 TCF12 ZNF121 ZNF302 ZNF416 ZNF202 YY2 ZNF488 ZFP41 ITFG2 CBX3P4 IQSEC3P1 RPS27P3 DCP1B CACNA1C-AS4 CACNA1C-IT3 PIR46918
GH12G002876 1.1 ENCODE 39.8 +65.1 65052 3.3 PKNOX1 FOXA2 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF302 ZNF143 ITFG2 RHNO1 TULP3 CBX3P4 NRIP2 RPS27P3 DCP1B FKBP4 GC12M002869
GH12G002357 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.5 -453.9 -453922 2.4 ZSCAN4 RAD21 ZNF155 RELB IKZF2 EGR2 ZNF362 TBX21 ZFP69B SMARCA4 ITFG2 GC12P002340 GC12P002493
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITFG2 on UCSC Golden Path with GeneCards custom track

Promoters for ITFG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047882 379 2001 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for ITFG2 Gene

Chromosome:
12
Start:
2,812,621 bp from pter
End:
2,859,791 bp from pter
Size:
47,171 bases
Orientation:
Plus strand

Genomic View for ITFG2 Gene

Genes around ITFG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG2 Gene

Proteins for ITFG2 Gene

  • Protein details for ITFG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969R8-ITFG2_HUMAN
    Recommended name:
    Integrin-alpha FG-GAP repeat-containing protein 2
    Protein Accession:
    Q969R8
    Secondary Accessions:
    • A8K4Z5
    • D3DUQ2
    • Q6PKU5
    • Q96SX6

    Protein attributes for ITFG2 Gene

    Size:
    447 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITFG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ITFG2 Gene

Post-translational modifications for ITFG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ITFG2 Gene

Domains & Families for ITFG2 Gene

Gene Families for ITFG2 Gene

Protein Domains for ITFG2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ITFG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ITFG2: view

No data available for UniProtKB/Swiss-Prot for ITFG2 Gene

Function for ITFG2 Gene

genes like me logo Genes that share phenotypes with ITFG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ITFG2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITFG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG2 Gene

Localization for ITFG2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITFG2 gene
Compartment Confidence
lysosome 5
nucleus 4
cytosol 3
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ITFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IEA --
GO:0005765 lysosomal membrane IDA 28199306
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with ITFG2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ITFG2 Gene

Pathways & Interactions for ITFG2 Gene

SuperPathways for ITFG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ITFG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002314 germinal center B cell differentiation IEA --
GO:0007229 integrin-mediated signaling pathway IEA --
GO:0034198 cellular response to amino acid starvation IMP 28199306
GO:0042149 cellular response to glucose starvation IMP 28199306
GO:1904262 negative regulation of TORC1 signaling IMP 28199306
genes like me logo Genes that share ontologies with ITFG2: view

No data available for Pathways by source and SIGNOR curated interactions for ITFG2 Gene

Drugs & Compounds for ITFG2 Gene

No Compound Related Data Available

Transcripts for ITFG2 Gene

Unigene Clusters for ITFG2 Gene

Integrin alpha FG-GAP repeat containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ITFG2

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a ·
SP1: - - - - -
SP2:
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - -
SP7:
SP8:
SP9:

ExUns: 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ITFG2 Gene

GeneLoc Exon Structure for
ITFG2
ECgene alternative splicing isoforms for
ITFG2

Expression for ITFG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITFG2 Gene

Protein differential expression in normal tissues from HIPED for ITFG2 Gene

This gene is overexpressed in Islet of Langerhans (12.5), Spleen (11.8), Lymph node (11.2), and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITFG2 Gene



NURSA nuclear receptor signaling pathways regulating expression of ITFG2 Gene:

ITFG2

SOURCE GeneReport for Unigene cluster for ITFG2 Gene:

Hs.446098

Evidence on tissue expression from TISSUES for ITFG2 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ITFG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITFG2 Gene

Orthologs for ITFG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITFG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ITFG2 34 35
  • 98.73 (n)
dog
(Canis familiaris)
Mammalia ITFG2 34 35
  • 87.76 (n)
rat
(Rattus norvegicus)
Mammalia Itfg2 34
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Itfg2 34 16 35
  • 87.13 (n)
cow
(Bos Taurus)
Mammalia ITFG2 34 35
  • 84.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
OneToMany
-- 35
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ITFG2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITFG2 34 35
  • 74.11 (n)
lizard
(Anolis carolinensis)
Reptilia ITFG2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg2 34
  • 67.3 (n)
zebrafish
(Danio rerio)
Actinopterygii itfg2 34 35
  • 68.86 (n)
Dr.17782 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2280 35
  • 38 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1115 34
Species where no ortholog for ITFG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITFG2 Gene

ENSEMBL:
Gene Tree for ITFG2 (if available)
TreeFam:
Gene Tree for ITFG2 (if available)

Paralogs for ITFG2 Gene

Pseudogenes.org Pseudogenes for ITFG2 Gene

genes like me logo Genes that share paralogs with ITFG2: view

No data available for Paralogs for ITFG2 Gene

Variants for ITFG2 Gene

Sequence variations from dbSNP and Humsavar for ITFG2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000043980 -- 2,829,941(+) GTGTG(A/G)TAGTG intron-variant
rs1000135508 -- 2,819,006(+) GACTC(C/T)GTCTC intron-variant
rs1000330666 -- 2,830,958(+) CCCCA(C/G)CCCCC intron-variant, downstream-variant-500B
rs1000641812 -- 2,819,953(+) CGGGG(A/G)CAGAC intron-variant
rs1000642943 -- 2,828,802(+) ACGCC(A/G)TTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITFG2 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV loss 17160897
esv3628321 CNV gain 21293372
esv3628322 CNV gain 21293372
nsv826194 CNV gain 20364138
nsv832311 CNV loss 17160897

Variation tolerance for ITFG2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITFG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ITFG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITFG2 Gene

Disorders for ITFG2 Gene

Relevant External Links for ITFG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITFG2

No disorders were found for ITFG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITFG2 Gene

Publications for ITFG2 Gene

  1. KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1. (PMID: 28199306) Wolfson R.L. … Sabatini D.M. (Nature 2017) 2 3 64
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for ITFG2 Gene

  • Addgene plasmids for ITFG2

Sources for ITFG2 Gene

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