Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ITFG2 Gene

Aliases for ITFG2 Gene

  • Integrin Alpha FG-GAP Repeat Containing 2 2 3 5
  • MDS028 3

External Ids for ITFG2 Gene

Previous GeneCards Identifiers for ITFG2 Gene

  • GC12P002793
  • GC12P002921

Summaries for ITFG2 Gene

GeneCards Summary for ITFG2 Gene

ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG2 Gene

Genomics for ITFG2 Gene

Regulatory Elements for ITFG2 Gene

Enhancers for ITFG2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITFG2 on UCSC Golden Path with GeneCards custom track

Promoters for ITFG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITFG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITFG2 Gene

2,812,621 bp from pter
2,859,791 bp from pter
47,171 bases
Plus strand

Genomic View for ITFG2 Gene

Genes around ITFG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG2 Gene

Proteins for ITFG2 Gene

  • Protein details for ITFG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Integrin-alpha FG-GAP repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K4Z5
    • D3DUQ2
    • Q6PKU5
    • Q96SX6

    Protein attributes for ITFG2 Gene

    447 amino acids
    Molecular mass:
    49313 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ITFG2 Gene


neXtProt entry for ITFG2 Gene

Proteomics data for ITFG2 Gene at MOPED

Post-translational modifications for ITFG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ITFG2 Gene

No data available for DME Specific Peptides for ITFG2 Gene

Domains & Families for ITFG2 Gene

Protein Domains for ITFG2 Gene


Suggested Antigen Peptide Sequences for ITFG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 FG-GAP repeats.
  • Contains 2 FG-GAP repeats.
genes like me logo Genes that share domains with ITFG2: view

No data available for Gene Families for ITFG2 Gene

Function for ITFG2 Gene

genes like me logo Genes that share phenotypes with ITFG2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ITFG2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG2 Gene

Localization for ITFG2 Gene

Subcellular locations from

Jensen Localization Image for ITFG2 Gene COMPARTMENTS Subcellular localization image for ITFG2 gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ITFG2 Gene

Pathways & Interactions for ITFG2 Gene

SuperPathways for ITFG2 Gene

No Data Available

Interacting Proteins for ITFG2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q969R8-ITFG2_HUMAN ENSP00000228799 for ITFG2 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for ITFG2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITFG2 Gene

Drugs & Compounds for ITFG2 Gene

No Compound Related Data Available

Transcripts for ITFG2 Gene

Unigene Clusters for ITFG2 Gene

Integrin alpha FG-GAP repeat containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a ·
SP1: - - - - -
SP3: - - - - - - - -
SP4: -
SP5: - - - - -
SP6: - - -

ExUns: 13b

Relevant External Links for ITFG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITFG2 Gene

mRNA expression in normal human tissues for ITFG2 Gene

Protein differential expression in normal tissues from HIPED for ITFG2 Gene

This gene is overexpressed in Islet of Langerhans (12.5), Spleen (11.8), Lymph node (11.2), and Testis (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ITFG2 Gene

SOURCE GeneReport for Unigene cluster for ITFG2 Gene Hs.446098

genes like me logo Genes that share expression patterns with ITFG2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ITFG2 Gene

Orthologs for ITFG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ITFG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITFG2 35
  • 84.05 (n)
  • 85.14 (a)
ITFG2 36
  • 88 (a)
(Canis familiaris)
Mammalia ITFG2 35
  • 87.76 (n)
  • 89.19 (a)
ITFG2 36
  • 64 (a)
(Mus musculus)
Mammalia Itfg2 35
  • 87.13 (n)
  • 90.29 (a)
Itfg2 16
Itfg2 36
  • 90 (a)
(Pan troglodytes)
Mammalia ITFG2 35
  • 98.73 (n)
  • 99.11 (a)
ITFG2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Itfg2 35
  • 87.72 (n)
  • 91.71 (a)
(Monodelphis domestica)
Mammalia ITFG2 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 82 (a)
-- 36
  • 73 (a)
(Gallus gallus)
Aves ITFG2 35
  • 74.11 (n)
  • 77.68 (a)
ITFG2 36
  • 73 (a)
(Anolis carolinensis)
Reptilia ITFG2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg2 35
  • 67.3 (n)
  • 68.87 (a)
(Danio rerio)
Actinopterygii Dr.17782 35
itfg2 35
  • 68.86 (n)
  • 71.36 (a)
itfg2 36
  • 69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1115 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2280 36
  • 38 (a)
Species with no ortholog for ITFG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ITFG2 Gene

Gene Tree for ITFG2 (if available)
Gene Tree for ITFG2 (if available)

Paralogs for ITFG2 Gene Pseudogenes for ITFG2 Gene

genes like me logo Genes that share paralogs with ITFG2: view

No data available for Paralogs for ITFG2 Gene

Variants for ITFG2 Gene

Sequence variations from dbSNP and Humsavar for ITFG2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2109109 -- 2,823,891(-) AGCAG(C/T)TTCAC nc-transcript-variant, reference, synonymous-codon
rs7138957 -- 2,811,319(+) aaaaa(A/T)aaaat upstream-variant-2KB
rs10848707 -- 2,814,095(+) CCTGC(C/T)ACCAT intron-variant
rs10848708 -- 2,822,286(+) CCATA(A/T)TTAAT intron-variant
rs7297106 -- 2,811,325(+) aaaat(A/T)aaatt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ITFG2 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV Loss 17160897
nsv826194 CNV Gain 20364138
nsv832311 CNV Loss 17160897

Variation tolerance for ITFG2 Gene

Residual Variation Intolerance Score: 13.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ITFG2 Gene

Disorders for ITFG2 Gene

Relevant External Links for ITFG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITFG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITFG2 Gene

Publications for ITFG2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Large-scale mapping of human protein-protein interactions by mass spectrometry. (PMID: 17353931) Ewing R.M. … Figeys D. (Mol. Syst. Biol. 2007) 3
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ITFG2 Gene

Sources for ITFG2 Gene