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Aliases for ITFG1 Gene

Aliases for ITFG1 Gene

  • Integrin Alpha FG-GAP Repeat Containing 1 2 3 5
  • LINKIN 2 3 4
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 1 3 4
  • LNKN-1 3 4
  • TIP 3 4
  • T Cell Immunomodulatory Protein 2
  • T-Cell Immunomodulatory Protein 3
  • 2310047C21Rik 3
  • Protein TIP 4
  • CDA08 3

External Ids for ITFG1 Gene

Previous GeneCards Identifiers for ITFG1 Gene

  • GC16M045747
  • GC16M033078

Summaries for ITFG1 Gene

GeneCards Summary for ITFG1 Gene

ITFG1 (Integrin Alpha FG-GAP Repeat Containing 1) is a Protein Coding gene. Diseases associated with ITFG1 include Alcohol-Induced Mental Disorder and Alcoholic Psychosis.

UniProtKB/Swiss-Prot for ITFG1 Gene

  • Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG1 Gene

Genomics for ITFG1 Gene

Regulatory Elements for ITFG1 Gene

Enhancers for ITFG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G048430 1.4 FANTOM5 Ensembl ENCODE 10.6 -968.8 -968814 4.9 PKNOX1 FOXA2 ZNF133 ZFP64 RAD21 FOS RELB ETV6 IKZF2 ZBTB11 SIAH1 N4BP1 LONP2 ITFG1 ABCC11 ENSG00000275909 GC16P048414
GH16G047523 1.1 Ensembl ENCODE 10.5 -59.6 -59570 1.2 ELF3 HNRNPUL1 TBP FOXA2 ARID4B RAD21 RARA SLC30A9 RCOR1 RELB ITFG1 PHKB SHCBP1 ENSG00000262038 RNA5SP425
GH16G047503 1 ENCODE 11.5 -40.3 -40293 1.4 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 PHKB ITFG1 GPT2 PIR32661
GH16G047565 0.9 Ensembl ENCODE 10.7 -101.5 -101452 1.2 FOSL1 JUND ATF3 EED JUN ZNF584 ETV6 GABPA ZNF592 ITFG1 PHKB EIF4BP5 LOC100420642
GH16G047617 0.6 ENCODE 10.7 -153.8 -153756 0.2 SOX13 TCF12 ZNF316 MAFG KDM1A EMSY MAFK ITFG1 PHKB NDUFA5P11 PIR31968
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ITFG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITFG1 Gene

47,154,387 bp from pter
47,464,149 bp from pter
309,763 bases
Minus strand

Genomic View for ITFG1 Gene

Genes around ITFG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG1 Gene

Proteins for ITFG1 Gene

  • Protein details for ITFG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell immunomodulatory protein
    Protein Accession:
    Secondary Accessions:
    • Q96SR4
    • Q9BRE2
    • Q9H2V9

    Protein attributes for ITFG1 Gene

    612 amino acids
    Molecular mass:
    68108 Da
    Quaternary structure:
    • Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
    • Sequence=AAG41782.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for ITFG1 Gene

Post-translational modifications for ITFG1 Gene

  • Glycosylation at isoforms=36, posLast=9595, isoforms=139, posLast=146146, isoforms=151, posLast=176176, posLast=188188, isoforms=226, isoforms=243, posLast=353353, posLast=371371, and posLast=482482
  • Modification sites at PhosphoSitePlus

Other Protein References for ITFG1 Gene

No data available for DME Specific Peptides for ITFG1 Gene

Domains & Families for ITFG1 Gene

Protein Domains for ITFG1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TIP family.
  • Belongs to the TIP family.
genes like me logo Genes that share domains with ITFG1: view

No data available for Gene Families for ITFG1 Gene

Function for ITFG1 Gene

Molecular function for ITFG1 Gene

UniProtKB/Swiss-Prot Function:
Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).
genes like me logo Genes that share phenotypes with ITFG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ITFG1

CRISPR Products

miRNA for ITFG1 Gene

miRTarBase miRNAs that target ITFG1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG1 Gene

Localization for ITFG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITFG1 Gene

Secreted. Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ITFG1 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ITFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ITFG1: view

Pathways & Interactions for ITFG1 Gene

SuperPathways for ITFG1 Gene

No Data Available

Interacting Proteins for ITFG1 Gene

Gene Ontology (GO) - Biological Process for ITFG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITFG1 Gene

Drugs & Compounds for ITFG1 Gene

(1) Drugs for ITFG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ITFG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITFG1: view

Transcripts for ITFG1 Gene

Unigene Clusters for ITFG1 Gene

Integrin alpha FG-GAP repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for ITFG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITFG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ITFG1 Gene

Protein differential expression in normal tissues from HIPED for ITFG1 Gene

This gene is overexpressed in Islet of Langerhans (13.3), Fetal Brain (8.8), Brain (7.1), Salivary gland (6.9), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITFG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITFG1 Gene:


SOURCE GeneReport for Unigene cluster for ITFG1 Gene:


mRNA Expression by UniProt/SwissProt for ITFG1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for ITFG1 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Liver(4.3)
  • Skin(4.3)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with ITFG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ITFG1 Gene

Orthologs for ITFG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITFG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ITFG1 34 35
  • 99.62 (n)
(Canis familiaris)
Mammalia ITFG1 34 35
  • 92.58 (n)
(Bos Taurus)
Mammalia ITFG1 34 35
  • 90.83 (n)
(Mus musculus)
Mammalia Itfg1 34 16 35
  • 86.81 (n)
(Rattus norvegicus)
Mammalia Itfg1 34
  • 85.82 (n)
(Monodelphis domestica)
Mammalia ITFG1 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ITFG1 35
  • 76 (a)
(Gallus gallus)
Aves ITFG1 34 35
  • 76.49 (n)
(Anolis carolinensis)
Reptilia ITFG1 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg1 34
  • 66.1 (n)
Str.10543 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32852 34
(Danio rerio)
Actinopterygii ITFG1 35
  • 67 (a)
itfg1 34
  • 62.99 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4814 34
fruit fly
(Drosophila melanogaster)
Insecta CG7739 34 35
  • 49.08 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011964 34
  • 47.37 (n)
(Caenorhabditis elegans)
Secernentea tag-256 34 35
  • 46.86 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
-- 35
  • 36 (a)
Species where no ortholog for ITFG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITFG1 Gene

Gene Tree for ITFG1 (if available)
Gene Tree for ITFG1 (if available)

Paralogs for ITFG1 Gene

No data available for Paralogs for ITFG1 Gene

Variants for ITFG1 Gene

Sequence variations from dbSNP and Humsavar for ITFG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000014357 -- 47,315,865(+) AGCTC(A/T)TTGCA intron-variant
rs1000025616 -- 47,341,959(+) AACCA(G/T)ATGGC intron-variant
rs1000035660 -- 47,158,119(+) GACAG(A/G)GTCTC intron-variant
rs1000050951 -- 47,183,444(+) GGGCA(C/G)ACTGC intron-variant
rs1000069112 -- 47,243,823(+) ATTAG(A/G)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITFG1 Gene

Variant ID Type Subtype PubMed ID
dgv518e214 CNV loss 21293372
esv2671280 CNV deletion 23128226
esv2758644 CNV gain 17122850
esv3359649 CNV insertion 20981092
esv34317 CNV gain 17911159
esv3638551 CNV loss 21293372
esv3638553 CNV gain 21293372
esv3638554 CNV loss 21293372
esv3638555 CNV loss 21293372
esv3638556 CNV loss 21293372
esv3638557 CNV gain 21293372
esv3638558 CNV loss 21293372
nsv1066115 CNV gain 25217958
nsv1138449 CNV deletion 24896259
nsv1796 CNV insertion 18451855
nsv472719 CNV novel sequence insertion 20440878
nsv474668 CNV novel sequence insertion 20440878
nsv510418 OTHER sequence alteration 20534489
nsv520355 CNV gain 19592680
nsv525170 CNV gain 19592680
nsv528423 CNV loss 19592680
nsv572537 CNV loss 21841781
nsv833217 CNV gain 17160897

Variation tolerance for ITFG1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITFG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITFG1 Gene

Disorders for ITFG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ITFG1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
alcohol-induced mental disorder
  • psychoses, alcoholic
alcoholic psychosis
  • alcoholic psychoses
- elite association - COSMIC cancer census association via MalaCards
Search ITFG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ITFG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ITFG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ITFG1 Gene

Publications for ITFG1 Gene

  1. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. (PMID: 12598909) Fiscella M. … Migone T.-S. (Nat. Biotechnol. 2003) 2 3 4 22 64
  2. LINKIN, a new transmembrane protein necessary for cell adhesion. (PMID: 25437307) Kato M. … Sternberg P.W. (Elife 2014) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ITFG1 Gene

Sources for ITFG1 Gene

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