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Aliases for ITFG1 Gene

Aliases for ITFG1 Gene

  • Integrin Alpha FG-GAP Repeat Containing 1 2 3 5
  • LINKIN 2 3 4
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 1 3 4
  • LNKN-1 3 4
  • TIP 3 4
  • T Cell Immunomodulatory Protein 2
  • 2310047C21Rik 3
  • Protein TIP 4
  • CDA08 3

External Ids for ITFG1 Gene

Previous GeneCards Identifiers for ITFG1 Gene

  • GC16M045747
  • GC16M033078

Summaries for ITFG1 Gene

GeneCards Summary for ITFG1 Gene

ITFG1 (Integrin Alpha FG-GAP Repeat Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ITFG1 Gene

  • Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG1 Gene

Genomics for ITFG1 Gene

Regulatory Elements for ITFG1 Gene

Enhancers for ITFG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ITFG1 on UCSC Golden Path with GeneCards custom track

Promoters for ITFG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ITFG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITFG1 Gene

Chromosome:
16
Start:
47,154,387 bp from pter
End:
47,464,149 bp from pter
Size:
309,763 bases
Orientation:
Minus strand

Genomic View for ITFG1 Gene

Genes around ITFG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG1 Gene

Proteins for ITFG1 Gene

  • Protein details for ITFG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TB96-TIP_HUMAN
    Recommended name:
    T-cell immunomodulatory protein
    Protein Accession:
    Q8TB96
    Secondary Accessions:
    • Q96SR4
    • Q9BRE2
    • Q9H2V9

    Protein attributes for ITFG1 Gene

    Size:
    612 amino acids
    Molecular mass:
    68108 Da
    Quaternary structure:
    • Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
    SequenceCaution:
    • Sequence=AAG41782.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for ITFG1 Gene

Proteomics data for ITFG1 Gene at MOPED

Post-translational modifications for ITFG1 Gene

  • Glycosylation at Asn 36, Asn 95, Asn 139, Asn 146, Asn 151, Asn 176, Asn 188, Asn 226, Asn 243, Asn 353, Asn 371, and Asn 482
  • Modification sites at PhosphoSitePlus

Other Protein References for ITFG1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for ITFG1
  • Santa Cruz Biotechnology (SCBT) Antibodies for ITFG1

No data available for DME Specific Peptides for ITFG1 Gene

Domains & Families for ITFG1 Gene

Protein Domains for ITFG1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TB96

UniProtKB/Swiss-Prot:

TIP_HUMAN :
  • Belongs to the TIP family.
  • Contains 1 FG-GAP repeat.
Family:
  • Belongs to the TIP family.
Similarity:
  • Contains 1 FG-GAP repeat.
genes like me logo Genes that share domains with ITFG1: view

No data available for Gene Families for ITFG1 Gene

Function for ITFG1 Gene

Molecular function for ITFG1 Gene

UniProtKB/Swiss-Prot Function:
Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).
genes like me logo Genes that share phenotypes with ITFG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ITFG1

miRNA for ITFG1 Gene

miRTarBase miRNAs that target ITFG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG1 Gene

Localization for ITFG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITFG1 Gene

Secreted. Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ITFG1 Gene COMPARTMENTS Subcellular localization image for ITFG1 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ITFG1: view

Pathways & Interactions for ITFG1 Gene

SuperPathways for ITFG1 Gene

No Data Available

Interacting Proteins for ITFG1 Gene

Gene Ontology (GO) - Biological Process for ITFG1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ITFG1 Gene

Drugs & Compounds for ITFG1 Gene

(1) Drugs for ITFG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ITFG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITFG1: view

Transcripts for ITFG1 Gene

Unigene Clusters for ITFG1 Gene

Integrin alpha FG-GAP repeat containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -
SP3:

Relevant External Links for ITFG1 Gene

GeneLoc Exon Structure for
ITFG1
ECgene alternative splicing isoforms for
ITFG1

Expression for ITFG1 Gene

mRNA expression in normal human tissues for ITFG1 Gene

Protein differential expression in normal tissues from HIPED for ITFG1 Gene

This gene is overexpressed in Islet of Langerhans (13.3), Fetal Brain (8.8), Brain (7.1), Salivary gland (6.9), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ITFG1 Gene



SOURCE GeneReport for Unigene cluster for ITFG1 Gene Hs.42217

mRNA Expression by UniProt/SwissProt for ITFG1 Gene

Q8TB96-TIP_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ITFG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ITFG1 Gene

Orthologs for ITFG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITFG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ITFG1 35
  • 90.83 (n)
  • 93.29 (a)
ITFG1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ITFG1 35
  • 92.58 (n)
  • 95.09 (a)
ITFG1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Itfg1 35
  • 86.81 (n)
  • 89.66 (a)
Itfg1 16
Itfg1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ITFG1 35
  • 99.62 (n)
  • 99.51 (a)
ITFG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Itfg1 35
  • 85.82 (n)
  • 88.18 (a)
oppossum
(Monodelphis domestica)
Mammalia ITFG1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ITFG1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves ITFG1 35
  • 76.49 (n)
  • 80.24 (a)
ITFG1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ITFG1 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg1 35
  • 66.1 (n)
  • 62.39 (a)
Str.10543 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32852 35
zebrafish
(Danio rerio)
Actinopterygii itfg1 35
  • 62.99 (n)
  • 68.79 (a)
ITFG1 36
  • 67 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4814 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011964 35
  • 47.37 (n)
  • 40.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7739 35
  • 49.08 (n)
  • 41.14 (a)
CG7739 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-256 35
  • 46.86 (n)
  • 32.26 (a)
tag-256 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
Species with no ortholog for ITFG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITFG1 Gene

ENSEMBL:
Gene Tree for ITFG1 (if available)
TreeFam:
Gene Tree for ITFG1 (if available)

Paralogs for ITFG1 Gene

No data available for Paralogs for ITFG1 Gene

Variants for ITFG1 Gene

Sequence variations from dbSNP and Humsavar for ITFG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4038737 -- 47,433,861(-) atata(-/TATA)TATTC intron-variant
rs8061997 -- 47,197,848(+) agaaa(C/T)gtgag intron-variant
rs8062391 -- 47,274,544(+) TTTTT(C/T)CCTTT intron-variant
rs171932 -- 47,277,660(+) TAGTA(A/G)GAACT intron-variant
rs174642 -- 47,269,724(+) ttcat(G/T)gtaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITFG1 Gene

Variant ID Type Subtype PubMed ID
nsv906660 CNV Loss 21882294
nsv528423 CNV Loss 19592680
nsv525170 CNV Gain 19592680
dgv887e1 CNV Complex 17122850
nsv1796 CNV Insertion 18451855
nsv510418 CNV Loss 20534489
esv2671280 CNV Deletion 23128226
nsv833217 CNV Gain 17160897
esv34317 CNV Gain 17911159
nsv520355 CNV Gain 19592680

Variation tolerance for ITFG1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.99% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ITFG1 Gene

Disorders for ITFG1 Gene

Relevant External Links for ITFG1

Genetic Association Database (GAD)
ITFG1
Human Genome Epidemiology (HuGE) Navigator
ITFG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ITFG1

No disorders were found for ITFG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITFG1 Gene

Publications for ITFG1 Gene

  1. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. (PMID: 12598909) Fiscella M. … Migone T.-S. (Nat. Biotechnol. 2003) 2 3 4 23 67
  2. LINKIN, a new transmembrane protein necessary for cell adhesion. (PMID: 25437307) Kato M. … Sternberg P.W. (Elife 2014) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3

Products for ITFG1 Gene

Sources for ITFG1 Gene

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