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Aliases for ITFG1 Gene

Aliases for ITFG1 Gene

  • Integrin Alpha FG-GAP Repeat Containing 1 2 3 5
  • LINKIN 2 3 4
  • Integrin-Alpha FG-GAP Repeat-Containing Protein 1 3 4
  • LNKN-1 3 4
  • TIP 3 4
  • T Cell Immunomodulatory Protein 2
  • T-Cell Immunomodulatory Protein 3
  • 2310047C21Rik 3
  • Protein TIP 4
  • CDA08 3

External Ids for ITFG1 Gene

Previous GeneCards Identifiers for ITFG1 Gene

  • GC16M045747
  • GC16M033078

Summaries for ITFG1 Gene

GeneCards Summary for ITFG1 Gene

ITFG1 (Integrin Alpha FG-GAP Repeat Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ITFG1 Gene

  • Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ITFG1 Gene

Genomics for ITFG1 Gene

Regulatory Elements for ITFG1 Gene

Enhancers for ITFG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ITFG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ITFG1 Gene

47,154,387 bp from pter
47,464,149 bp from pter
309,763 bases
Minus strand

Genomic View for ITFG1 Gene

Genes around ITFG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ITFG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ITFG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ITFG1 Gene

Proteins for ITFG1 Gene

  • Protein details for ITFG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell immunomodulatory protein
    Protein Accession:
    Secondary Accessions:
    • Q96SR4
    • Q9BRE2
    • Q9H2V9

    Protein attributes for ITFG1 Gene

    612 amino acids
    Molecular mass:
    68108 Da
    Quaternary structure:
    • Interacts with RUVBL1, RUVBL2 and alpha-tubulin.
    • Sequence=AAG41782.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for ITFG1 Gene

Post-translational modifications for ITFG1 Gene

  • Glycosylation at Asn 36, Asn 95, Asn 139, Asn 146, Asn 151, Asn 176, Asn 188, Asn 226, Asn 243, Asn 353, Asn 371, and Asn 482
  • Modification sites at PhosphoSitePlus

Other Protein References for ITFG1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for ITFG1

No data available for DME Specific Peptides for ITFG1 Gene

Domains & Families for ITFG1 Gene

Protein Domains for ITFG1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TIP family.
  • Contains 1 FG-GAP repeat.
  • Belongs to the TIP family.
  • Contains 1 FG-GAP repeat.
genes like me logo Genes that share domains with ITFG1: view

No data available for Gene Families for ITFG1 Gene

Function for ITFG1 Gene

Molecular function for ITFG1 Gene

UniProtKB/Swiss-Prot Function:
Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).
genes like me logo Genes that share phenotypes with ITFG1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ITFG1

CRISPR Products

miRNA for ITFG1 Gene

miRTarBase miRNAs that target ITFG1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ITFG1 Gene

Localization for ITFG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ITFG1 Gene

Secreted. Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for ITFG1 Gene COMPARTMENTS Subcellular localization image for ITFG1 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ITFG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with ITFG1: view

Pathways & Interactions for ITFG1 Gene

SuperPathways for ITFG1 Gene

No Data Available

Interacting Proteins for ITFG1 Gene

Gene Ontology (GO) - Biological Process for ITFG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ITFG1 Gene

Drugs & Compounds for ITFG1 Gene

(1) Drugs for ITFG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for ITFG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ITFG1: view

Transcripts for ITFG1 Gene

Unigene Clusters for ITFG1 Gene

Integrin alpha FG-GAP repeat containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ITFG1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: -

Relevant External Links for ITFG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ITFG1 Gene

mRNA expression in normal human tissues for ITFG1 Gene

Protein differential expression in normal tissues from HIPED for ITFG1 Gene

This gene is overexpressed in Islet of Langerhans (13.3), Fetal Brain (8.8), Brain (7.1), Salivary gland (6.9), and Heart (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ITFG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ITFG1 Gene:


SOURCE GeneReport for Unigene cluster for ITFG1 Gene:


mRNA Expression by UniProt/SwissProt for ITFG1 Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ITFG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for ITFG1 Gene

Orthologs for ITFG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ITFG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ITFG1 34
  • 90.83 (n)
  • 93.29 (a)
ITFG1 35
  • 93 (a)
(Canis familiaris)
Mammalia ITFG1 34
  • 92.58 (n)
  • 95.09 (a)
ITFG1 35
  • 95 (a)
(Mus musculus)
Mammalia Itfg1 34
  • 86.81 (n)
  • 89.66 (a)
Itfg1 16
Itfg1 35
  • 90 (a)
(Pan troglodytes)
Mammalia ITFG1 34
  • 99.62 (n)
  • 99.51 (a)
ITFG1 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Itfg1 34
  • 85.82 (n)
  • 88.18 (a)
(Monodelphis domestica)
Mammalia ITFG1 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ITFG1 35
  • 76 (a)
(Gallus gallus)
Aves ITFG1 34
  • 76.49 (n)
  • 80.24 (a)
ITFG1 35
  • 78 (a)
(Anolis carolinensis)
Reptilia ITFG1 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia itfg1 34
  • 66.1 (n)
  • 62.39 (a)
Str.10543 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32852 34
(Danio rerio)
Actinopterygii itfg1 34
  • 62.99 (n)
  • 68.79 (a)
ITFG1 35
  • 67 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4814 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011964 34
  • 47.37 (n)
  • 40.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7739 34
  • 49.08 (n)
  • 41.14 (a)
CG7739 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea tag-256 34
  • 46.86 (n)
  • 32.26 (a)
tag-256 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
-- 35
  • 36 (a)
Species where no ortholog for ITFG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ITFG1 Gene

Gene Tree for ITFG1 (if available)
Gene Tree for ITFG1 (if available)

Paralogs for ITFG1 Gene

No data available for Paralogs for ITFG1 Gene

Variants for ITFG1 Gene

Sequence variations from dbSNP and Humsavar for ITFG1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3095621 -- 47,169,003(-) accac(A/G)accat intron-variant
rs3095627 -- 47,242,909(-) agatc(A/C)agaaa intron-variant
rs3095628 -- 47,217,104(-) TGTTC(A/C/G)TACAG intron-variant
rs3095629 -- 47,204,928(-) CAGCA(C/T)ATGAG intron-variant
rs3105544 -- 47,166,778(-) CAAAC(A/T)AATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ITFG1 Gene

Variant ID Type Subtype PubMed ID
dgv518e214 CNV loss 21293372
esv2671280 CNV deletion 23128226
esv2758644 CNV gain 17122850
esv3359649 CNV insertion 20981092
esv34317 CNV gain 17911159
esv3638551 CNV loss 21293372
esv3638553 CNV gain 21293372
esv3638554 CNV loss 21293372
esv3638555 CNV loss 21293372
esv3638556 CNV loss 21293372
esv3638557 CNV gain 21293372
esv3638558 CNV loss 21293372
nsv1066115 CNV gain 25217958
nsv1138449 CNV deletion 24896259
nsv1796 CNV insertion 18451855
nsv472719 CNV novel sequence insertion 20440878
nsv474668 CNV novel sequence insertion 20440878
nsv510418 OTHER sequence alteration 20534489
nsv520355 CNV gain 19592680
nsv525170 CNV gain 19592680
nsv528423 CNV loss 19592680
nsv572537 CNV loss 21841781
nsv833217 CNV gain 17160897

Variation tolerance for ITFG1 Gene

Residual Variation Intolerance Score: 23.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ITFG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ITFG1 Gene

Disorders for ITFG1 Gene

Relevant External Links for ITFG1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ITFG1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ITFG1 Gene

Publications for ITFG1 Gene

  1. TIP, a T-cell factor identified using high-throughput screening increases survival in a graft-versus-host disease model. (PMID: 12598909) Fiscella M. … Migone T.-S. (Nat. Biotechnol. 2003) 2 3 4 22 65
  2. LINKIN, a new transmembrane protein necessary for cell adhesion. (PMID: 25437307) Kato M. … Sternberg P.W. (Elife 2014) 2 3 4 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for ITFG1 Gene

Sources for ITFG1 Gene

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