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Aliases for ISYNA1 Gene

Aliases for ISYNA1 Gene

  • Inositol-3-Phosphate Synthase 1 2 3
  • Myo-Inositol 1-Phosphate Synthase A1 3 4
  • Myo-Inositol 1-Phosphate Synthase 2 4
  • MI-1-P Synthase 3 4
  • MIP Synthase 3 4
  • EC 5.5.1.4 4 64
  • IPS 1 3 4
  • INO1 3 4
  • IPS 3 6
  • IPS-1 3
  • HINO1 4
  • INOS 3
  • HIPS 4

External Ids for ISYNA1 Gene

Summaries for ISYNA1 Gene

Entrez Gene Summary for ISYNA1 Gene

  • This gene encodes an inositol-3-phosphate synthase enzyme. The encoded protein plays a critical role in the myo-inositol biosynthesis pathway by catalyzing the rate-limiting conversion of glucose 6-phosphate to myoinositol 1-phosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for ISYNA1 Gene

ISYNA1 (Inositol-3-Phosphate Synthase 1) is a Protein Coding gene. Diseases associated with ISYNA1 include fungal meningitis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include inositol-3-phosphate synthase activity.

UniProtKB/Swiss-Prot for ISYNA1 Gene

  • Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISYNA1 Gene

Genomics for ISYNA1 Gene

Genomic Location for ISYNA1 Gene

Start:
18,434,388 bp from pter
End:
18,438,649 bp from pter
Size:
4,262 bases
Orientation:
Minus strand

Genomic View for ISYNA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISYNA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISYNA1 Gene

Regulatory Elements for ISYNA1 Gene

Proteins for ISYNA1 Gene

  • Protein details for ISYNA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPH2-INO1_HUMAN
    Recommended name:
    Inositol-3-phosphate synthase 1
    Protein Accession:
    Q9NPH2
    Secondary Accessions:
    • B3KRT1
    • G5E9U0
    • Q6NXT5
    • Q7Z525
    • Q9BT65
    • Q9H2Y2
    • Q9NSU0
    • Q9NVW7

    Protein attributes for ISYNA1 Gene

    Size:
    558 amino acids
    Molecular mass:
    61068 Da
    Cofactor:
    Name=NAD(+); Xref=ChEBI:CHEBI:57540;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP97151.1; Type=Frameshift; Positions=82, 85, 496; Evidence={ECO:0000305};

    Alternative splice isoforms for ISYNA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ISYNA1 Gene

Proteomics data for ISYNA1 Gene at MOPED

Post-translational modifications for ISYNA1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys155, Lys222, and Lys312

Domains for ISYNA1 Gene

UniProtKB/Swiss-Prot:

INO1_HUMAN
Family:
  • Belongs to the myo-inositol 1-phosphate synthase family.:
    • Q9NPH2
genes like me logo Genes that share domains with ISYNA1: view

No data available for Gene Families for ISYNA1 Gene

Function for ISYNA1 Gene

Molecular function for ISYNA1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.57 mM for 6-phosphate {ECO:0000269 PubMed:15024000}; KM=8 uM for NAD {ECO:0000269 PubMed:15024000}; pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:15024000};
UniProtKB/Swiss-Prot CatalyticActivity: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by mood-stabilizing drugs such as valproate (VPA) and lithium.
UniProtKB/Swiss-Prot Function: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
UniProtKB/Swiss-Prot Induction: By glucose and lovastain. Up-regulation is prevented by mevalonic acid, farnesol, and geranylgeraniol. Up-regulated by E2F1.

Enzyme Numbers (IUBMB) for ISYNA1 Gene

Gene Ontology (GO) - Molecular Function for ISYNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004512 inositol-3-phosphate synthase activity TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ISYNA1: view

miRNA for ISYNA1 Gene

miRTarBase miRNAs that target ISYNA1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ISYNA1 Gene

Localization for ISYNA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISYNA1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISYNA1 Gene COMPARTMENTS Subcellular localization image for ISYNA1 gene
Compartment Confidence
cytosol 4
nucleus 2
chloroplast 1
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ISYNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ISYNA1: view

Pathways for ISYNA1 Gene

genes like me logo Genes that share pathways with ISYNA1: view

Pathways by source for ISYNA1 Gene

UniProtKB/Swiss-Prot Q9NPH2-INO1_HUMAN

  • Pathway: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2

Gene Ontology (GO) - Biological Process for ISYNA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006021 inositol biosynthetic process IEA --
GO:0008654 phospholipid biosynthetic process IEA --
GO:0043647 inositol phosphate metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ISYNA1: view

Compounds for ISYNA1 Gene

(6) HMDB Compounds for ISYNA1 Gene

Compound Synonyms Cas Number PubMed IDs
1D-myo-Inositol 3-phosphate
  • D-myo-Inositol 3-phosphate
2831-74-5
Glucose 6-phosphate
  • D(+)-Glucopyranose 6-phosphate
56-73-5
Inositol phosphate
  • 1D-myo-Inositol 1-monophosphate
15421-51-9
Myo-inositol 1-phosphate
  • 1-(dihydrogen phosphate) DL-myo-Inositol
573-35-3
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with ISYNA1: view

Transcripts for ISYNA1 Gene

Unigene Clusters for ISYNA1 Gene

Inositol-3-phosphate synthase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISYNA1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ·
SP1: - - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - - -
SP9: -
SP10: - -
SP11: - - -
SP12: - - -
SP13:
SP14: - - - - - - -
SP15: -

ExUns: 11c ^ 12a · 12b · 12c
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for ISYNA1 Gene

GeneLoc Exon Structure for
ISYNA1
ECgene alternative splicing isoforms for
ISYNA1

Expression for ISYNA1 Gene

mRNA expression in normal human tissues for ISYNA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISYNA1 Gene

This gene is overexpressed in Testis (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISYNA1 Gene

SOURCE GeneReport for Unigene cluster for ISYNA1 Gene Hs.405873

mRNA Expression by UniProt/SwissProt for ISYNA1 Gene

Q9NPH2-INO1_HUMAN
Tissue specificity: Highly expressed in testis, ovary, heart, placenta and pancreas. Weakly expressed in blood leukocyte, thymus, skeletal muscle and colon.
genes like me logo Genes that share expressions with ISYNA1: view

Orthologs for ISYNA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ISYNA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISYNA1 36
  • 99.58 (n)
  • 99.5 (a)
ISYNA1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ISYNA1 36
  • 87.77 (n)
  • 92.63 (a)
ISYNA1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ISYNA1 36
  • 88.25 (n)
  • 92.81 (a)
ISYNA1 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Isyna1 36
  • 82.49 (n)
  • 88.67 (a)
Isyna1 16
Isyna1 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ISYNA1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Isyna1 36
  • 82.43 (n)
  • 89.03 (a)
lizard
(Anolis carolinensis)
Reptilia ISYNA1 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52653 36
tropical clawed frog
(Silurana tropicalis)
Amphibia isyna1 36
  • 65.99 (n)
  • 71.59 (a)
Str.563 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011830 36
  • 65.86 (n)
  • 61.34 (a)
fruit fly
(Drosophila melanogaster)
Insecta Inos 36
  • 66.73 (n)
  • 63.04 (a)
Inos 37
  • 59 (a)
OneToOne
Inos 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea inos-1 36
  • 57.53 (n)
  • 54.21 (a)
inos-1 37
  • 53 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes INO1 36
  • 54.13 (n)
  • 53.86 (a)
INO1 37
  • 49 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16412g 36
  • 53.07 (n)
  • 52.05 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7841 36
soybean
(Glycine max)
eudicotyledons Gma.15564 36
thale cress
(Arabidopsis thaliana)
eudicotyledons MIPS2 36
  • 59.93 (n)
  • 61.2 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.974 36
corn
(Zea mays)
Liliopsida Zm.2986 36
rice
(Oryza sativa)
Liliopsida Os03g0192700 36
  • 65 (n)
  • 63 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.220 36
bread mold
(Neurospora crassa)
Ascomycetes NCU06666 36
  • 63.21 (n)
  • 59.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14431 36
Species with no ortholog for ISYNA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • zebrafish (Danio rerio)

Evolution for ISYNA1 Gene

ENSEMBL:
Gene Tree for ISYNA1 (if available)
TreeFam:
Gene Tree for ISYNA1 (if available)

Paralogs for ISYNA1 Gene

Pseudogenes.org Pseudogenes for ISYNA1 Gene

genes like me logo Genes that share paralogs with ISYNA1: view

No data available for Paralogs for ISYNA1 Gene

Variants for ISYNA1 Gene

Sequence variations from dbSNP and Humsavar for ISYNA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2303696 -- 18,438,074(-) GGGGC(A/G)GGGAC intron-variant, upstream-variant-2KB, nc-transcript-variant
rs2303697 -- 18,435,868(-) AACCT(A/G)TCGGC reference, synonymous-codon, nc-transcript-variant
rs2385089 -- 18,439,624(+) TAAAA(A/C)AAAAA upstream-variant-2KB
rs2431132 -- 18,440,087(+) agtga(A/G)ccatg upstream-variant-2KB
rs2434471 -- 18,440,060(-) gagct(C/T)aagtg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ISYNA1 Gene

Variant ID Type Subtype PubMed ID
nsv911274 CNV Loss 21882294
nsv911275 CNV Loss 21882294
nsv911276 CNV Loss 21882294
dgv3782n71 CNV Loss 21882294
dgv3783n71 CNV Loss 21882294
esv2677302 CNV Deletion 23128226
nsv482217 CNV Gain 20164927

Relevant External Links for ISYNA1 Gene

HapMap Linkage Disequilibrium report
ISYNA1
Human Gene Mutation Database (HGMD)
ISYNA1

Disorders for ISYNA1 Gene

(1) MalaCards Diseases for ISYNA1 Gene

Search for ISYNA1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ISYNA1 Gene

genes like me logo Genes that share disorders with ISYNA1: view

No data available for UniProtKB/Swiss-Prot for ISYNA1 Gene

Publications for ISYNA1 Gene

  1. Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. (PMID: 15024000) Ju S. … Greenberg M.L. (J. Biol. Chem. 2004) 2 3 4
  2. cDNA cloning and gene expression analysis of human myo-inositol 1- phosphate synthase. (PMID: 12941308) Guan G. … Shechter I. (Arch. Biochem. Biophys. 2003) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter. (PMID: 15464731) Seelan R.S. … Parthasarathy R.N. (Arch. Biochem. Biophys. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ISYNA1 Gene

Sources for ISYNA1 Gene

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