Aliases for ISY1-RAB43 Gene
External Ids for ISY1-RAB43 Gene
- HGNC: 42969
- Entrez Gene: 100534599
- Ensembl: ENSG00000261796
Previous GeneCards Identifiers for ISY1-RAB43 Gene
- GC03U901776
- GC03M128807
Summaries for ISY1-RAB43 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for ISY1-RAB43 Gene
ISY1-RAB43 (ISY1-RAB43 Readthrough) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. An important paralog of this gene is ISY1.
No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISY1-RAB43 Gene
Genomics for ISY1-RAB43 Gene
Regulatory Elements for ISY1-RAB43 Gene
Promoters for ISY1-RAB43 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around ISY1-RAB43 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ISY1-RAB43 Gene
- Chromosome:
- 3
- Start:
- 129,087,569 bp from pter
- End:
- 129,161,230 bp from pter
- Size:
- 73,662 bases
- Orientation:
- Minus strand
Genomic View for ISY1-RAB43 Gene
Genes around ISY1-RAB43 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q21.3 by Ensembl
- 3q by Entrez Gene
- 3q21.3 by HGNC
ISY1-RAB43 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ISY1-RAB43 Gene
Proteins for ISY1-RAB43 Gene
-
Protein details for ISY1-RAB43 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H9XFA1
- Recommended name:
- ISY1-RAB43
- Protein Accession:
- H9XFA1
Protein attributes for ISY1-RAB43 Gene
- Size:
- 39 amino acids
- Molecular mass:
- 4391 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ISY1-RAB43 Gene
No Post-translational modifications
Other Protein References for ISY1-RAB43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for ISY1-RAB43
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISY1-RAB43
- Search GeneTex for Proteins for ISY1-RAB43
Assay Products
No data available for DME Specific Peptides for ISY1-RAB43 Gene
Domains & Families for ISY1-RAB43 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ISY1-RAB43 Gene
Function for ISY1-RAB43 Gene
Phenotypes for ISY1-RAB43 Gene
- GenomeRNAi human phenotypes for ISY1-RAB43:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- Search ViGene Biosciences for ISY1-RAB43
CRISPR Products
- Browse CRISPR knockouts for ISY1-RAB43
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
miRNA for ISY1-RAB43 Gene
- miRTarBase miRNAs that target ISY1-RAB43
miRNA Products
- Search ViGene Biosciences for ISY1-RAB43
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for ISY1-RAB43 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- Search ViGene Biosciences for ISY1-RAB43
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1-RAB43 Gene
Localization for ISY1-RAB43 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ISY1-RAB43 Gene
Pathways & Interactions for ISY1-RAB43 Gene
More details on SuperPathways for ISY1-RAB43| Superpath | Contained pathways | |
|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.43
|
Pathways by source for ISY1-RAB43 Gene
1 KEGG pathway for ISY1-RAB43 Gene
Interacting Proteins for ISY1-RAB43 Gene
No data available for SIGNOR curated interactions for ISY1-RAB43 Gene
Transcripts for ISY1-RAB43 Gene
mRNA/cDNA for ISY1-RAB43 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for ISY1-RAB43
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
miRNA Products
- Search ViGene Biosciences for ISY1-RAB43
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
Flow Cytometry Products
Relevant External Links for ISY1-RAB43 Gene
- GeneLoc Exon Structure for
- ISY1-RAB43
- ECgene alternative splicing isoforms for
- ISY1-RAB43
Expression for ISY1-RAB43 Gene
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ISY1-RAB43 Gene
Orthologs for ISY1-RAB43 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | ISY1 35 |
|
||
| ISY1 36 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | ISY1 35 |
|
||
| ISY1 36 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Isy1 35 |
|
||
| Isy1 16 |
|
||||
| Isy1 36 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Isy1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 36 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 36 |
|
OneToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | ISY1-RAB43 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ISY1 35 |
|
||
| -- 36 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 36 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | isy1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rab43 35 |
|
||
| rab43 36 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004225 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9667 35 |
|
||
| CG9667 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | F53B7.3 35 |
|
||
| F53B7.3 36 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ISY1 36 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18790 35 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0602500 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany |
- Species with no ortholog for ISY1-RAB43:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ISY1-RAB43 Gene
- ENSEMBL:
- Gene Tree for ISY1-RAB43 (if available)
- TreeFam:
- Gene Tree for ISY1-RAB43 (if available)
Paralogs for ISY1-RAB43 Gene
(1) SIMAP similar genes for ISY1-RAB43 Gene using alignment to 1 proteins:
Variants for ISY1-RAB43 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4927933 | -- | 129,126,473(+) | CCCCG(A/T)CCAGA | intron-variant | |
| rs73862932 | -- | 129,126,087(+) | TCATA(C/T)AGAGG | intron-variant | |
| rs7646647 | -- | 129,125,855(+) | tttat(C/T)ttttg | intron-variant | |
| rs74533708 | -- | 129,126,853(+) | GTTGC(A/G)GCAGA | intron-variant | |
| rs62265334 | -- | 129,124,613(+) | TAGCC(A/G)GGTGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5251n71 | CNV | Loss | 21882294 |
| dgv5252n71 | CNV | Loss | 21882294 |
| nsv877471 | CNV | Loss | 21882294 |
| dgv5253n71 | CNV | Gain+Loss | 21882294 |
| nsv433217 | CNV | Loss | 18776910 |
| esv2725900 | CNV | Deletion | 23290073 |
Residual Variation Intolerance Score:
27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.29;
6.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ISY1-RAB43 Gene
- HapMap Linkage Disequilibrium report
- ISY1-RAB43
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISY1-RAB43 Gene
Disorders for ISY1-RAB43 Gene
Relevant External Links for ISY1-RAB43
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ISY1-RAB43
No disorders were found for ISY1-RAB43 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1-RAB43 Gene
Publications for ISY1-RAB43 Gene
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 67
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3
Products for ISY1-RAB43 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISY1-RAB43
- Browse OriGene Inhibitory RNA Products For ISY1-RAB43
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for ISY1-RAB43
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for ISY1-RAB43
- GenScript Custom Assay Services for ISY1-RAB43
- GenScript Custom overexpressing Cell Line Services for ISY1-RAB43
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ISY1-RAB43
- ViGene Biosciences adenoviral particle packaged cDNA for ISY1-RAB43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- Search ViGene Biosciences for ISY1-RAB43
- Search ViGene Biosciences for ISY1-RAB43
- Search ViGene Biosciences for ISY1-RAB43
Sources for ISY1-RAB43 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
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- (130) diseasecard
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- (138) MedlinePlus
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- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon