Aliases for ISY1-RAB43 Gene
External Ids for ISY1-RAB43 Gene
- HGNC: 42969
- Entrez Gene: 100534599
- Ensembl: ENSG00000261796
Previous GeneCards Identifiers for ISY1-RAB43 Gene
- GC03U901776
- GC03M128807
Summaries for ISY1-RAB43 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for ISY1-RAB43 Gene
ISY1-RAB43 (ISY1-RAB43 Readthrough) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. An important paralog of this gene is ISY1.
Additional gene information for ISY1-RAB43 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISY1-RAB43 Gene
Genomics for ISY1-RAB43 Gene
GeneHancer (GH) Regulatory Elements for ISY1-RAB43 Gene
Regulatory Element Products
Genomic Locations for ISY1-RAB43 Gene
- chr3:129,087,569-129,161,230
- (GRCh38/hg38)
- Size:
- 73,662 bases
- Orientation:
- Minus strand
- chr3:128,806,412-128,880,073
- (GRCh37/hg19)
Genomic View for ISY1-RAB43 Gene
- Cytogenetic band:
-
- 3q21.3 by Ensembl
- 3q21.3 by Entrez Gene
- 3q21.3 by HGNC


RefSeq DNA sequence for ISY1-RAB43 Gene
Proteins for ISY1-RAB43 Gene
-
Protein details for ISY1-RAB43 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H9XFA1
- Recommended name:
- ISY1-RAB43
- Protein Accession:
- H9XFA1
Protein attributes for ISY1-RAB43 Gene
- Size:
- 39 amino acids
- Molecular mass:
- 4391 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ISY1-RAB43 Gene
Other Protein References for ISY1-RAB43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISY1-RAB43
- Origene Custom Protein Services for ISY1-RAB43
- Search GeneTex for Proteins for ISY1-RAB43
Assay Products
No data available for DME Specific Peptides for ISY1-RAB43 Gene
Domains & Families for ISY1-RAB43 Gene
Gene Families for ISY1-RAB43 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ISY1-RAB43 Gene
Function for ISY1-RAB43 Gene
Phenotypes for ISY1-RAB43 Gene
- GenomeRNAi human phenotypes for ISY1-RAB43:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
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CRISPR Products
- Browse CRISPR knockouts for ISY1-RAB43
- genomics-online: gRNA clones - Search results for available ISY1-RAB43 gene related products
- Applied Biological Materials CRISPR for ISY1-RAB43
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
miRNA for ISY1-RAB43 Gene
- miRTarBase miRNAs that target ISY1-RAB43
-
- hsa-mir-6815-3p (MIRT527045)
- hsa-mir-103a-2-5p (MIRT527046)
- hsa-mir-6888-5p (MIRT527047)
- hsa-mir-122-5p (MIRT736109)
- hsa-mir-1287-5p (MIRT737071)
- hsa-mir-211-3p (MIRT738932)
- hsa-mir-3135b (MIRT740130)
- hsa-mir-3907 (MIRT742818)
- hsa-mir-4257 (MIRT743409)
- hsa-mir-4436a (MIRT744434)
- hsa-mir-4633-3p (MIRT746299)
- hsa-mir-4685-5p (MIRT746961)
- hsa-mir-4700-3p (MIRT747268)
- hsa-mir-4786-3p (MIRT748866)
- hsa-mir-5000-3p (MIRT749321)
- hsa-mir-504-3p (MIRT749548)
- hsa-mir-505-5p (MIRT749582)
- hsa-mir-6500-5p (MIRT752882)
- hsa-mir-6837-5p (MIRT757243)
- hsa-mir-6874-5p (MIRT758096)
- hsa-mir-6880-5p (MIRT758307)
- hsa-mir-7113-5p (MIRT759109)
- hsa-mir-7114-5p (MIRT759143)
- hsa-mir-7843-3p (MIRT759748)
- hsa-mir-7845-5p (MIRT759799)
- hsa-mir-7847-3p (MIRT759844)
miRNA Products
- Search ViGene Biosciences for ISY1-RAB43
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available ISY1-RAB43 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ISY1-RAB43
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ISY1-RAB43 gene related products
- orf clones - Search results for available ISY1-RAB43 gene related products
- Applied Biological Materials Clones for ISY1-RAB43
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ISY1-RAB43
-
ViGene Biosciences adenoviral particle packaged cDNA for ISY1-RAB43 gene
-
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- Search ViGene Biosciences for ISY1-RAB43
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1-RAB43 Gene
Localization for ISY1-RAB43 Gene
- Nuclear speckles (4)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ISY1-RAB43 Gene
Pathways & Interactions for ISY1-RAB43 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | mRNA Splicing - Major Pathway |
.50
|
Pathways by source for ISY1-RAB43 Gene
1 KEGG pathway for ISY1-RAB43 Gene
Interacting Proteins for ISY1-RAB43 Gene
No data available for SIGNOR curated interactions for ISY1-RAB43 Gene
Transcripts for ISY1-RAB43 Gene
mRNA/cDNA for ISY1-RAB43 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for ISY1-RAB43
- genomics-online: gRNA clones - Search results for available ISY1-RAB43 gene related products
- Applied Biological Materials CRISPR for ISY1-RAB43
-
Vectors and viruses for KO, Activation, Repression, and more
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
miRNA Products
- Search ViGene Biosciences for ISY1-RAB43
Inhibitory RNA Products
- genomics-online: shRNA clones - Search results for available ISY1-RAB43 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ISY1-RAB43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ISY1-RAB43
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available ISY1-RAB43 gene related products
- orf clones - Search results for available ISY1-RAB43 gene related products
- Applied Biological Materials Clones for ISY1-RAB43
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Relevant External Links for ISY1-RAB43 Gene
- GeneLoc Exon Structure for
- ISY1-RAB43
- ECgene alternative splicing isoforms for
- ISY1-RAB43
Expression for ISY1-RAB43 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISY1-RAB43 Gene

Evidence on tissue expression from TISSUES for ISY1-RAB43 Gene
- Lung(4)
- Nervous system(4)
Primer Products
- genomics-online: primer clones - Search results for available ISY1-RAB43 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISY1-RAB43 Gene
Orthologs for ISY1-RAB43 Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ISY1-RAB43 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | ISY1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
mouse (Mus musculus) |
Mammalia | Isy1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Isy1 33 |
|
||
cow (Bos Taurus) |
Mammalia | ISY1 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | ISY1 33 |
|
||
-- 34 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | isy1 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rab43 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG9667 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004225 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | F53B7.3 33 34 |
|
||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ISY1 34 |
|
OneToMany | |
thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18790 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os02g0602500 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ISY1-RAB43 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ISY1-RAB43 Gene
- ENSEMBL:
- Gene Tree for ISY1-RAB43 (if available)
- TreeFam:
- Gene Tree for ISY1-RAB43 (if available)
Paralogs for ISY1-RAB43 Gene
(1) SIMAP similar genes for ISY1-RAB43 Gene using alignment to 1 proteins:
Variants for ISY1-RAB43 Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000043258 | -- | 129,138,940(-) | C/T | intron_variant | |
rs1000056556 | -- | 129,127,664(-) | G/C | intron_variant | |
rs1000087837 | -- | 129,095,236(-) | C/T | intron_variant | |
rs1000121834 | -- | 129,120,132(-) | G/A | intron_variant | |
rs1000124666 | -- | 129,112,145(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2725900 | CNV | deletion | 23290073 |
esv3435887 | CNV | insertion | 20981092 |
nsv1073246 | CNV | deletion | 25765185 |
nsv1131722 | CNV | deletion | 24896259 |
nsv433217 | CNV | loss | 18776910 |
nsv474466 | CNV | novel sequence insertion | 20440878 |
nsv474677 | CNV | novel sequence insertion | 20440878 |
nsv591650 | CNV | loss | 21841781 |
Additional Variant Information for ISY1-RAB43 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ISY1-RAB43
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISY1-RAB43 Gene
Disorders for ISY1-RAB43 Gene
Additional Disease Information for ISY1-RAB43
No disorders were found for ISY1-RAB43 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1-RAB43 Gene
Publications for ISY1-RAB43 Gene
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 58
Products for ISY1-RAB43 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available ISY1-RAB43 related products ranked by validation data
- antibodies-online: Search results for available ISY1-RAB43 related products ranked by validation data
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Sources for ISY1-RAB43 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
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- (54) Leiden
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- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
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- (86) RefSeq
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- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
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- (108) SCBT
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- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew