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Aliases for ISY1-RAB43 Gene

Aliases for ISY1-RAB43 Gene

  • ISY1-RAB43 Readthrough 2 3 5

External Ids for ISY1-RAB43 Gene

Previous GeneCards Identifiers for ISY1-RAB43 Gene

  • GC03U901776
  • GC03M128807

Summaries for ISY1-RAB43 Gene

Entrez Gene Summary for ISY1-RAB43 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for ISY1-RAB43 Gene

ISY1-RAB43 (ISY1-RAB43 Readthrough) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. An important paralog of this gene is ISY1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISY1-RAB43 Gene

Genomics for ISY1-RAB43 Gene

Regulatory Elements for ISY1-RAB43 Gene

Promoters for ISY1-RAB43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001373523 230 2801 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D

Genomic Location for ISY1-RAB43 Gene

129,087,569 bp from pter
129,161,230 bp from pter
73,662 bases
Minus strand

Genomic View for ISY1-RAB43 Gene

Genes around ISY1-RAB43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISY1-RAB43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISY1-RAB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISY1-RAB43 Gene

Proteins for ISY1-RAB43 Gene

  • Protein details for ISY1-RAB43 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for ISY1-RAB43 Gene

    39 amino acids
    Molecular mass:
    4391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISY1-RAB43 Gene

Post-translational modifications for ISY1-RAB43 Gene

No Post-translational modifications

Other Protein References for ISY1-RAB43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISY1-RAB43 Gene

Domains & Families for ISY1-RAB43 Gene

Protein Domains for ISY1-RAB43 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ISY1-RAB43: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ISY1-RAB43 Gene

Function for ISY1-RAB43 Gene

Phenotypes for ISY1-RAB43 Gene

genes like me logo Genes that share phenotypes with ISY1-RAB43: view

Animal Model Products

miRNA for ISY1-RAB43 Gene

miRTarBase miRNAs that target ISY1-RAB43

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1-RAB43 Gene

Localization for ISY1-RAB43 Gene

Subcellular locations from

Jensen Localization Image for ISY1-RAB43 Gene COMPARTMENTS Subcellular localization image for ISY1-RAB43 gene
Compartment Confidence
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ISY1-RAB43 Gene

Pathways & Interactions for ISY1-RAB43 Gene

SuperPathways for ISY1-RAB43 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with ISY1-RAB43: view

Pathways by source for ISY1-RAB43 Gene

1 KEGG pathway for ISY1-RAB43 Gene

Interacting Proteins for ISY1-RAB43 Gene

Gene Ontology (GO) - Biological Process for ISY1-RAB43 Gene


No data available for SIGNOR curated interactions for ISY1-RAB43 Gene

Transcripts for ISY1-RAB43 Gene

mRNA/cDNA for ISY1-RAB43 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ISY1-RAB43 Gene

No ASD Table

Relevant External Links for ISY1-RAB43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISY1-RAB43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ISY1-RAB43 Gene

mRNA expression in normal human tissues for ISY1-RAB43 Gene
genes like me logo Genes that share expression patterns with ISY1-RAB43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ISY1-RAB43 Gene

Orthologs for ISY1-RAB43 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ISY1-RAB43 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ISY1-RAB43 35
  • 99 (a)
(Canis familiaris)
Mammalia ISY1 34 35
  • 91.67 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
(Mus musculus)
Mammalia Isy1 34 16 35
  • 89.32 (n)
(Rattus norvegicus)
Mammalia Isy1 34
  • 88.46 (n)
(Bos Taurus)
Mammalia ISY1 34 35
  • 86.5 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
(Gallus gallus)
Aves ISY1 34
  • 78.33 (n)
-- 35
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia isy1 34
  • 73.88 (n)
(Danio rerio)
Actinopterygii rab43 34 35
  • 75.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9667 34 35
  • 62.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004225 34
  • 59.41 (n)
(Caenorhabditis elegans)
Secernentea F53B7.3 34 35
  • 57.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISY1 35
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18790 34
  • 55.79 (n)
(Oryza sativa)
Liliopsida Os02g0602500 34
  • 51.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
Species where no ortholog for ISY1-RAB43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ISY1-RAB43 Gene

Gene Tree for ISY1-RAB43 (if available)
Gene Tree for ISY1-RAB43 (if available)

Paralogs for ISY1-RAB43 Gene

Paralogs for ISY1-RAB43 Gene

(1) SIMAP similar genes for ISY1-RAB43 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ISY1-RAB43: view

Variants for ISY1-RAB43 Gene

Sequence variations from dbSNP and Humsavar for ISY1-RAB43 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1021123 -- 129,118,310(+) TGTAA(C/T)GGGAA intron-variant
rs1061847 -- 129,129,391(-) TCCCA(A/C)AAAAA intron-variant, utr-variant-3-prime
rs10664499 -- 129,140,359(+) CAAAC(-/TTAG)CTTAC intron-variant
rs10684214 -- 129,140,362(+) ACTTA(-/GTTA)CTTAC intron-variant
rs10934871 -- 129,114,364(+) GCAAT(A/G)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ISY1-RAB43 Gene

Variant ID Type Subtype PubMed ID
esv2725900 CNV deletion 23290073
esv3435887 CNV insertion 20981092
nsv1073246 CNV deletion 25765185
nsv1131722 CNV deletion 24896259
nsv433217 CNV loss 18776910
nsv474466 CNV novel sequence insertion 20440878
nsv474677 CNV novel sequence insertion 20440878
nsv591650 CNV loss 21841781

Variation tolerance for ISY1-RAB43 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISY1-RAB43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISY1-RAB43 Gene

Disorders for ISY1-RAB43 Gene

Relevant External Links for ISY1-RAB43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ISY1-RAB43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1-RAB43 Gene

Publications for ISY1-RAB43 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 64

Products for ISY1-RAB43 Gene

Sources for ISY1-RAB43 Gene

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