Aliases for ISY1-RAB43 Gene
External Ids for ISY1-RAB43 Gene
- HGNC: 42969
- Entrez Gene: 100534599
- Ensembl: ENSG00000261796
Previous GeneCards Identifiers for ISY1-RAB43 Gene
- GC03U901776
- GC03M128807
Summaries for ISY1-RAB43 Gene
-
This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for ISY1-RAB43 Gene
ISY1-RAB43 (ISY1-RAB43 Readthrough) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. An important paralog of this gene is ISY1.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISY1-RAB43 Gene
Genomics for ISY1-RAB43 Gene
Regulatory Elements for ISY1-RAB43 Gene
Regulatory Element Products
Genomic Location for ISY1-RAB43 Gene
- Chromosome:
- 3
- Start:
- 129,087,569 bp from pter
- End:
- 129,161,230 bp from pter
- Size:
- 73,662 bases
- Orientation:
- Minus strand
Genomic View for ISY1-RAB43 Gene
Genes around ISY1-RAB43 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q21.3 by Ensembl
- 3q21.3 by Entrez Gene
- 3q21.3 by HGNC
ISY1-RAB43 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ISY1-RAB43 Gene
Proteins for ISY1-RAB43 Gene
-
Protein details for ISY1-RAB43 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- H9XFA1
- Recommended name:
- ISY1-RAB43
- Protein Accession:
- H9XFA1
Protein attributes for ISY1-RAB43 Gene
- Size:
- 39 amino acids
- Molecular mass:
- 4391 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for ISY1-RAB43 Gene
No Post-translational modifications
Other Protein References for ISY1-RAB43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for ISY1-RAB43
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISY1-RAB43
- Origene Custom Protein Services for ISY1-RAB43
- Search GeneTex for Proteins for ISY1-RAB43
Assay Products
No data available for DME Specific Peptides for ISY1-RAB43 Gene
Domains & Families for ISY1-RAB43 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ISY1-RAB43 Gene
Function for ISY1-RAB43 Gene
Phenotypes for ISY1-RAB43 Gene
- GenomeRNAi human phenotypes for ISY1-RAB43:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ISY1-RAB43
-
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- Search ViGene Biosciences for ISY1-RAB43
CRISPR Products
- Browse CRISPR knockouts for ISY1-RAB43
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
miRNA for ISY1-RAB43 Gene
- miRTarBase miRNAs that target ISY1-RAB43
miRNA Products
- Search ViGene Biosciences for ISY1-RAB43
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ISY1-RAB43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ISY1-RAB43
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ISY1-RAB43
-
ViGene Biosciences adenoviral particle packaged cDNA for ISY1-RAB43 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- Search ViGene Biosciences for ISY1-RAB43
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1-RAB43 Gene
Localization for ISY1-RAB43 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ISY1-RAB43 Gene
Pathways & Interactions for ISY1-RAB43 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.50
|
|
Pathways by source for ISY1-RAB43 Gene
1 KEGG pathway for ISY1-RAB43 Gene
Interacting Proteins for ISY1-RAB43 Gene
No data available for SIGNOR curated interactions for ISY1-RAB43 Gene
Transcripts for ISY1-RAB43 Gene
mRNA/cDNA for ISY1-RAB43 Gene
- (1) REFSEQ mRNAs :
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for ISY1-RAB43
- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
miRNA Products
- Search ViGene Biosciences for ISY1-RAB43
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ISY1-RAB43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ISY1-RAB43
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Relevant External Links for ISY1-RAB43 Gene
- GeneLoc Exon Structure for
- ISY1-RAB43
- ECgene alternative splicing isoforms for
- ISY1-RAB43
Expression for ISY1-RAB43 Gene
mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISY1-RAB43 Gene
Evidence on tissue expression from TISSUES for ISY1-RAB43 Gene
- Lung(4)
- Nervous system(4)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISY1-RAB43 Gene
Orthologs for ISY1-RAB43 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ISY1-RAB43 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ISY1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| mouse (Mus musculus) |
Mammalia | Isy1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Isy1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ISY1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | ISY1 34 |
|
||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | isy1 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rab43 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9667 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004225 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F53B7.3 34 35 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | ISY1 35 |
|
OneToMany | |
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G18790 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0602500 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ISY1-RAB43 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for ISY1-RAB43 Gene
- ENSEMBL:
- Gene Tree for ISY1-RAB43 (if available)
- TreeFam:
- Gene Tree for ISY1-RAB43 (if available)
Paralogs for ISY1-RAB43 Gene
(1) SIMAP similar genes for ISY1-RAB43 Gene using alignment to 1 proteins:
Variants for ISY1-RAB43 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000043258 | -- | 129,138,940(+) | TATAA(C/T)TTTTT | intron-variant | |
| rs1000056556 | -- | 129,127,664(+) | CAGCT(C/G)GGTGC | intron-variant, utr-variant-3-prime | |
| rs1000087837 | -- | 129,095,236(+) | GTGAC(C/T)CCACA | intron-variant | |
| rs1000121834 | -- | 129,120,132(+) | TCCCC(A/G)TCACA | intron-variant | |
| rs1000124666 | -- | 129,112,145(+) | AGCTA(C/T)TCAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2725900 | CNV | deletion | 23290073 |
| esv3435887 | CNV | insertion | 20981092 |
| nsv1073246 | CNV | deletion | 25765185 |
| nsv1131722 | CNV | deletion | 24896259 |
| nsv433217 | CNV | loss | 18776910 |
| nsv474466 | CNV | novel sequence insertion | 20440878 |
| nsv474677 | CNV | novel sequence insertion | 20440878 |
| nsv591650 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.29;
6.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ISY1-RAB43 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ISY1-RAB43
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISY1-RAB43 Gene
Disorders for ISY1-RAB43 Gene
Relevant External Links for ISY1-RAB43
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ISY1-RAB43
No disorders were found for ISY1-RAB43 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1-RAB43 Gene
Publications for ISY1-RAB43 Gene
- Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 64
Products for ISY1-RAB43 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
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- Browse Immunoprecipitation Assays
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- Browse OriGene Antibodies
- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ISY1-RAB43
- Origene Custom Protein Services for ISY1-RAB43
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- Browse OriGene qPCR primer pairs and template standards
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for ISY1-RAB43 in any vector
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- GenScript: Design CRISPR guide RNA sequences for ISY1-RAB43
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- CloneReady with Over 120,000 Genes
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for ISY1-RAB43 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ISY1-RAB43 gene
- Search ViGene Biosciences for ISY1-RAB43
- Horizon Cell Lines for ISY1-RAB43
- Cyagen custom Knockout/knockin (KOKI) mouse models for ISY1-RAB43
- VectorBuilder custom plasmid, inducible vectors for ISY1-RAB43
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ISY1-RAB43
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ISY1-RAB43 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (19) MINT
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
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- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
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- (109) TreeFam
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- (154) TISSUES
- (155) Gene ORGANizer