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Aliases for ISY1-RAB43 Gene

Aliases for ISY1-RAB43 Gene

  • ISY1-RAB43 Readthrough 2 3 5

External Ids for ISY1-RAB43 Gene

Previous GeneCards Identifiers for ISY1-RAB43 Gene

  • GC03U901776
  • GC03M128807

Summaries for ISY1-RAB43 Gene

Entrez Gene Summary for ISY1-RAB43 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring ISY1 (ISY1 splicing factor homolog) and RAB43 (RAB43, member RAS oncogene family) gene on chromosome 3. The read-through transcript encodes a protein that shares sequence identity with the upstream gene product, but its C-terminus is distinct due to a frameshift relative to the downstream gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for ISY1-RAB43 Gene

ISY1-RAB43 (ISY1-RAB43 Readthrough) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. An important paralog of this gene is ISY1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISY1-RAB43 Gene

Genomics for ISY1-RAB43 Gene

Regulatory Elements for ISY1-RAB43 Gene

Promoters for ISY1-RAB43 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ISY1-RAB43 on UCSC Golden Path with GeneCards custom track

Genomic Location for ISY1-RAB43 Gene

129,087,569 bp from pter
129,161,230 bp from pter
73,662 bases
Minus strand

Genomic View for ISY1-RAB43 Gene

Genes around ISY1-RAB43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISY1-RAB43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISY1-RAB43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISY1-RAB43 Gene

Proteins for ISY1-RAB43 Gene

  • Protein details for ISY1-RAB43 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for ISY1-RAB43 Gene

    39 amino acids
    Molecular mass:
    4391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISY1-RAB43 Gene

Proteomics data for ISY1-RAB43 Gene at MOPED

Post-translational modifications for ISY1-RAB43 Gene

No Post-translational modifications

Other Protein References for ISY1-RAB43 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISY1-RAB43 Gene

Domains & Families for ISY1-RAB43 Gene

Protein Domains for ISY1-RAB43 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ISY1-RAB43: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ISY1-RAB43 Gene

Function for ISY1-RAB43 Gene

Phenotypes for ISY1-RAB43 Gene

genes like me logo Genes that share phenotypes with ISY1-RAB43: view

Animal Model Products

miRNA for ISY1-RAB43 Gene

miRTarBase miRNAs that target ISY1-RAB43

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1-RAB43 Gene

Localization for ISY1-RAB43 Gene

Subcellular locations from

Jensen Localization Image for ISY1-RAB43 Gene COMPARTMENTS Subcellular localization image for ISY1-RAB43 gene
Compartment Confidence
nucleus 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ISY1-RAB43 Gene

Pathways & Interactions for ISY1-RAB43 Gene

SuperPathways for ISY1-RAB43 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with ISY1-RAB43: view

Pathways by source for ISY1-RAB43 Gene

1 KEGG pathway for ISY1-RAB43 Gene

Interacting Proteins for ISY1-RAB43 Gene

Gene Ontology (GO) - Biological Process for ISY1-RAB43 Gene


No data available for SIGNOR curated interactions for ISY1-RAB43 Gene

Drugs & Compounds for ISY1-RAB43 Gene

No Compound Related Data Available

Transcripts for ISY1-RAB43 Gene

mRNA/cDNA for ISY1-RAB43 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ISY1-RAB43 Gene

No ASD Table

Relevant External Links for ISY1-RAB43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISY1-RAB43 Gene

mRNA expression in normal human tissues for ISY1-RAB43 Gene

mRNA expression in normal human tissues for ISY1-RAB43 Gene
genes like me logo Genes that share expression patterns with ISY1-RAB43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ISY1-RAB43 Gene

Orthologs for ISY1-RAB43 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ISY1-RAB43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ISY1 35
  • 86.5 (n)
  • 94.72 (a)
ISY1 36
  • 95 (a)
(Canis familiaris)
Mammalia ISY1 35
  • 91.67 (n)
  • 98.24 (a)
ISY1 36
  • 98 (a)
(Mus musculus)
Mammalia Isy1 35
  • 89.32 (n)
  • 98.24 (a)
Isy1 16
Isy1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Isy1 35
  • 88.46 (n)
  • 97.53 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 74 (a)
(Pan troglodytes)
Mammalia ISY1-RAB43 36
  • 99 (a)
(Gallus gallus)
Aves ISY1 35
  • 78.33 (n)
  • 90 (a)
-- 36
  • 78 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia isy1 35
  • 73.88 (n)
  • 84.4 (a)
(Danio rerio)
Actinopterygii rab43 35
  • 75.59 (n)
  • 82.39 (a)
rab43 36
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004225 35
  • 59.41 (n)
  • 62.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9667 35
  • 62.17 (n)
  • 62.55 (a)
CG9667 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea F53B7.3 35
  • 57.31 (n)
  • 51.92 (a)
F53B7.3 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISY1 36
  • 30 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18790 35
  • 55.79 (n)
  • 51.23 (a)
(Oryza sativa)
Liliopsida Os02g0602500 35
  • 51.79 (n)
  • 45.83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
Species with no ortholog for ISY1-RAB43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ISY1-RAB43 Gene

Gene Tree for ISY1-RAB43 (if available)
Gene Tree for ISY1-RAB43 (if available)

Paralogs for ISY1-RAB43 Gene

Paralogs for ISY1-RAB43 Gene

(1) SIMAP similar genes for ISY1-RAB43 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ISY1-RAB43: view

Variants for ISY1-RAB43 Gene

Sequence variations from dbSNP and Humsavar for ISY1-RAB43 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4927933 -- 129,126,473(+) CCCCG(A/T)CCAGA intron-variant
rs73862932 -- 129,126,087(+) TCATA(C/T)AGAGG intron-variant
rs7646647 -- 129,125,855(+) tttat(C/T)ttttg intron-variant
rs74533708 -- 129,126,853(+) GTTGC(A/G)GCAGA intron-variant
rs62265334 -- 129,124,613(+) TAGCC(A/G)GGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ISY1-RAB43 Gene

Variant ID Type Subtype PubMed ID
dgv5251n71 CNV Loss 21882294
dgv5252n71 CNV Loss 21882294
nsv877471 CNV Loss 21882294
dgv5253n71 CNV Gain+Loss 21882294
nsv433217 CNV Loss 18776910
esv2725900 CNV Deletion 23290073

Variation tolerance for ISY1-RAB43 Gene

Residual Variation Intolerance Score: 27.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ISY1-RAB43 Gene

Disorders for ISY1-RAB43 Gene

Relevant External Links for ISY1-RAB43

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ISY1-RAB43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1-RAB43 Gene

Publications for ISY1-RAB43 Gene

  1. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 67
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3

Products for ISY1-RAB43 Gene

Sources for ISY1-RAB43 Gene