Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ISY1 Gene

protein-coding   GIFtS: 45
GCID: GC03M128846

ISY1 Splicing Factor Homolog (S. Cerevisiae)

  Search for ISY1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ISY1 Splicing Factor Homolog (S. Cerevisiae)1 2
Functional Spliceosome-Associated Protein 331 2
KIAA11603 5
FSAP332
Pre-MRNA-Splicing Factor ISY1 Homolog2

External Ids:    HGNC: 292011   Entrez Gene: 574612   Ensembl: ENSG000002406827   OMIM: 6127645   UniProtKB: Q9ULR03   

Export aliases for ISY1 gene to outside databases

Previous GC identifers: GC03M130292 GC03M126234


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ISY1 Gene: 
ISY1 (ISY1 splicing factor homolog (S. cerevisiae)) is a protein-coding gene. Among its related super-pathways are mRNA Splicing - Major Pathway. An important paralog of this gene is ISY1-RAB43.

UniProtKB/Swiss-Prot: ISY1_HUMAN, Q9ULR0
Function: May play a role in pre-mRNA splicing (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ISY1 gene promoter:
         E2F-3a   E2F-4   Elk-1   E2F-5   AML1a   STAT5A   POU6F1 (c2)   E2F-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ISY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

ISY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISY1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M128846:  view genomic region     (about GC identifiers)

Start:
128,846,258 bp from pter      End:
128,880,136 bp from pter
Size:
33,879 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ISY1_HUMAN, Q9ULR0 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor ISY1 homolog  
Size: 285 amino acids; 32992 Da
Subunit: Identified in the spliceosome C complex
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAA86474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q96IL2 Q9BT05
Alternative splicing: 3 isoforms:  Q9ULR0-3   Q9ULR0-1   Q9ULR0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ISY1: NX_Q9ULR0

Explore proteomics data for ISY1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9ULR0

  • ISY1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ISY1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186398.1  NP_065752.1  

    ENSEMBL proteins: 
     ENSP00000376973   ENSP00000273541   ENSP00000426416   ENSP00000376970   ENSP00000422403  

    Human Recombinant Protein Products for ISY1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ISY1
    OriGene Protein Over-expression Lysate for ISY1
    OriGene MassSpec for ISY1 
    OriGene Custom Protein Services for ISY1
    GenScript Custom Purified and Recombinant Proteins Services for ISY1
    Novus Biologicals ISY1 Protein
    Novus Biologicals ISY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0071013catalytic step 2 spliceosome IDA11991638

    ISY1 for ontologies           About GeneDecksing



    ISY1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ISY1
    GenScript Custom Superior Antibodies Services for ISY1
    Novus Biologicals ISY1 Antibodies
    Abcam antibodies for ISY1
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for ISY1
    Search LSBio for Antibodies for ISY1 

    Assay Products for ISY1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ISY1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ISY1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR009360 Isy1

    Graphical View of Domain Structure for InterPro Entry Q9ULR0

    ProtoNet protein and cluster: Q9ULR0

    UniProtKB/Swiss-Prot: ISY1_HUMAN, Q9ULR0
    Similarity: Belongs to the ISY1 family


    ISY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISY1_HUMAN, Q9ULR0
    Function: May play a role in pre-mRNA splicing (Potential)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    ISY1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ISY1:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ISY1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ISY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISY1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISY1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISY1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ISY1 (see all 9):
    hsa-miR-485-5p hsa-miR-3163 hsa-miR-548p hsa-miR-888 hsa-miR-519e* hsa-miR-211 hsa-miR-515-5p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidISY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ISY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ISY1
    Sirion Biotech Customized adenovirus for overexpression of ISY1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ISY1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISY1 (NM_020701)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISY1
    Sirion Biotech Customized lentivirus for stable overexpression of ISY1 
                         Customized lentivirus expression plasmids for stable overexpression of ISY1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ISY1
    Search LifeMap BioReagents cell lines for ISY1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISY1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ISY1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for ISY1):
        Spliceosome


    ISY1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ISY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for ISY1 (Q9ULR02, 3 ENSP000003769734) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XAB2Q9HCS72, 3, ENSP000003511374MINT-8337046 MINT-8331954 I2D: score=1 STRING: ENSP00000351137
    DHX8Q145622, ENSP000002624154MINT-8331569 MINT-8337123 STRING: ENSP00000262415
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    ISY1Q9ULR02MINT-8337112
    CDC40ENSP000003043704STRING: ENSP00000304370
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638

    ISY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ISY1

    Search CenterWatch for drugs/clinical trials and news about ISY1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ISY1 gene (2 alternative transcripts): 
    NM_001199469.1  NM_020701.3  

    Unigene Cluster for ISY1:

    ISY1 splicing factor homolog (S. cerevisiae)
    Hs.512661  [show with all ESTs]
    Unigene Representative Sequence: NM_001204890
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393295(uc010hsz.2 uc010hta.2 uc003elp.2) ENST00000471497
    ENST00000273541 ENST00000471306 ENST00000496163 ENST00000393292 ENST00000485703

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISY1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ISY1 (see all 9):
    hsa-miR-485-5p hsa-miR-3163 hsa-miR-548p hsa-miR-888 hsa-miR-519e* hsa-miR-211 hsa-miR-515-5p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidISY1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ISY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISY1
    Clone
    Products:
         
    OriGene clones in human, mouse for ISY1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISY1 (NM_020701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISY1
    Sirion Biotech Customized lentivirus for stable overexpression of ISY1 
                         Customized lentivirus expression plasmids for stable overexpression of ISY1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ISY1
    OriGene qSTAR qPCR primer pairs in human, mouse for ISY1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ISY1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISY1

    Additional mRNA sequence: 

    AK024035.1 BC004122.2 BC004442.1 BC007409.2 BC019849.1 HQ013244.1 

    16 DOTS entries:

    DT.456025  DT.100038093  DT.120862682  DT.92418662  DT.95229920  DT.100798218  DT.100690515  DT.100798230 
    DT.100679481  DT.100689789  DT.100038095  DT.95350688  DT.97851543  DT.120690482  DT.120916639  DT.87016444 

    24/393 AceView cDNA sequences (see all 393):

    BU838746 BQ054288 BC004442 AW129926 BQ051942 BQ231767 BM984704 CR614909 
    BQ069284 BE909025 BC004122 BQ694259 BQ059285 BQ675818 NM_020701 AL603611 
    AA677436 BI918318 AI740737 AI580675 AU143205 BE304528 BC019849 BU154744 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ISY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGACCGGAG
    ISY1 Expression
    About this image


    See ISY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ISY1

    SOURCE GeneReport for Unigene cluster: Hs.512661
        SABiosciences Custom PCR Arrays for ISY1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ISY1
    OriGene qSTAR qPCR primer pairs in human, mouse for ISY1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ISY1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISY1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ISY1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    --
    77(a)
    1 → many
    12(5051630-5061707)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    88(a)
    1 → many
    2(159117262-159161392)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194642 Xenopus laevis transcribed sequence with weak similarity more 76.38(n)    BJ635570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab436
    RAB43, member RAS oncogene family
    81(a)
    1 → many
    11(461201-473071)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96676
    --
    61(a)
    1 → many
    3R(3951009-3952055)
    worm
    (Caenorhabditis elegans)
    Secernentea F53B7.36
    Protein F53B7.3
    50(a)
    1 → many
    V(10999425-11000792)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISY16
    Member of NineTeen Complex (NTC) that contains Prp...
    29(a)
    1 → many
    X(528697-529404)
            Species with no ortholog for ISY1

    ENSEMBL Gene Tree for ISY1 (if available)
    TreeFam Gene Tree for ISY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ISY1 gene
    ISY1-RAB432  
    1 SIMAP similar gene for ISY1 using alignment to 4 protein entries:     ISY1_HUMAN (see all proteins):
    ISY1-RAB43

    ISY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ISY1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2725900CNV Deletion23290073
    dgv5251n71CNV Loss21882294
    nsv877471CNV Loss21882294
    dgv5252n71CNV Loss21882294
    dgv5253n71CNV Gain+Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ISY1
    DNA2.0 Custom Variant and Variant Library Synthesis for ISY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ISY1 for disorders           About MalaCards
    OMIM gene information: 612764    OMIM disorders: --


    ISY1 for disorders           About GeneDecksing


    Export disorders for ISY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ISY1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with ISY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. (PubMed id 16103217)1, 3 Villa T. and Guthrie C. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (2002)
    4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
    5. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57461 HGNC: 29201 AceView: KIAA1160andRAB43 Ensembl:ENSG00000240682 euGenes: HUgn57461
    ECgene: ISY1 Kegg: 57461 H-InvDB: ISY1

    (According to HUGE)
    About This Section
    HUGE: KIAA1160

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ISY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ISY1 gene:
    Search GeneIP for patents involving ISY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ISY1  
     OriGene qPCR primer pairs and template standards for ISY1   OriGene Protein Over-expression Lysate for ISY1  
     OriGene MassSpec something-or-other for ISY1   OriGene clones in human, mouse for ISY1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ISY1   OriGene Purified Protein for ISY1  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ISY1   OriGene Custom Protein Services for ISY1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ISY1
     QIAGEN SeqTarget long-range PCR primers for resequencing ISY1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISY1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISY1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISY1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISY1
     GenScript Custom Purified and Recombinant Proteins Services for ISY1 GenScript cDNA clones with any tag delivered in your preferred vector for ISY1
     GenScript Custom Assay Services for ISY1 GenScript Custom Superior Antibodies Services for ISY1
     GenScript Custom overexpressing Cell Line Services for ISY1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ISY1 promoter
     Search Chromatin IP Primers for ISY1
     RT2 qPCR Primer Assay in human, mouse, rat ISY1
     Search GNC Networks for ISY1
     SABiosciences Custom PCR Arrays for ISY1
     Search Tocris compounds for ISY1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ISY1 antibodies
     ISY1 proteins
     ISY1 lysates
     Antibodies for ISY1
     See all of Abcam's Antibodies, Kits and Proteins for ISY1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for ISY1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISY1
     SwitchGear 3'UTR luciferase reporter plasmids for ISY1
     SwitchGear Promoter luciferase reporter plasmids for ISY1
     Search ThermoFisher Antibodies for ISY1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISY1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ISY1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ISY1
    Customized:
     lentivirus for stable overexpression of ISY1
     lentivirus expression plasmids for stable overexpression of ISY1
     adenovirus for overexpression of ISY1
     Search LSBio for Antibodies for ISY1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ISY1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4