Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ISY1 Gene

protein-coding   GIFtS: 46
GCID: GC03M128846

ISY1 Splicing Factor Homolog (S. Cerevisiae)

  Search for ISY1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ISY1 Splicing Factor Homolog (S. Cerevisiae)1 2
Functional Spliceosome-Associated Protein 331 2
KIAA11603 5
FSAP332
Pre-MRNA-Splicing Factor ISY1 Homolog2

External Ids:    HGNC: 292011   Entrez Gene: 574612   Ensembl: ENSG000002406827   OMIM: 6127645   UniProtKB: Q9ULR03   

Export aliases for ISY1 gene to outside databases

Previous GC identifers: GC03M130292 GC03M126234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ISY1 Gene:
ISY1 (ISY1 splicing factor homolog (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is ISY1-RAB43.

UniProtKB/Swiss-Prot: ISY1_HUMAN, Q9ULR0
Function: May play a role in pre-mRNA splicing (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISY1 gene promoter:
         E2F-3a   E2F-4   Elk-1   E2F-5   AML1a   STAT5A   POU6F1 (c2)   E2F-2   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISY1 promoter sequence
   Search Chromatin IP Primers for ISY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

ISY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISY1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M128846:  view genomic region     (about GC identifiers)

Start:
128,846,258 bp from pter      End:
128,880,136 bp from pter
Size:
33,879 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ISY1_HUMAN, Q9ULR0 (See protein sequence)
Recommended Name: Pre-mRNA-splicing factor ISY1 homolog  
Size: 285 amino acids; 32992 Da
Subunit: Identified in the spliceosome C complex
Sequence caution: Sequence=BAA86474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q96IL2 Q9BT05
Alternative splicing: 3 isoforms:  Q9ULR0-3   Q9ULR0-1   Q9ULR0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ISY1: NX_Q9ULR0

Explore proteomics data for ISY1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ISY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186398.1  NP_065752.1  

    ENSEMBL proteins: 
     ENSP00000376973   ENSP00000273541   ENSP00000426416   ENSP00000376970   ENSP00000422403  

    ISY1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ISY1
    OriGene Protein Over-expression Lysate for ISY1
    OriGene MassSpec for ISY1
    OriGene Custom Protein Services for ISY1
    GenScript Custom Purified and Recombinant Proteins Services for ISY1
    Novus Biologicals ISY1 Protein
    Novus Biologicals ISY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    ISY1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ISY1
    Novus Biologicals ISY1 Antibodies
    Abcam antibodies for ISY1
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for ISY1
    Search LSBio for Antibodies for ISY1

    ISY1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ISY1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ISY1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR009360 Isy1

    Graphical View of Domain Structure for InterPro Entry Q9ULR0

    ProtoNet protein and cluster: Q9ULR0

    UniProtKB/Swiss-Prot: ISY1_HUMAN, Q9ULR0
    Similarity: Belongs to the ISY1 family


    ISY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISY1_HUMAN, Q9ULR0
    Function: May play a role in pre-mRNA splicing (Potential)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    ISY1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ISY1:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISY1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ISY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISY1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISY1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ISY1:
    hsa-mir-421 (MIRT039403)

    Block miRNA regulation of human, mouse, rat ISY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISY1 (see all 9):
    hsa-miR-485-5p hsa-miR-3163 hsa-miR-548p hsa-miR-888 hsa-miR-519e* hsa-miR-211 hsa-miR-515-5p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidISY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ISY1
    Predesigned siRNA for gene silencing in human, mouse, rat ISY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ISY1

    Clone
    Products:
         
    OriGene clones in human, mouse for ISY1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISY1 (NM_020701)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISY1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ISY1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ISY1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISY1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ISY1_HUMAN, Q9ULR0: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0071013catalytic step 2 spliceosome IDA11991638

    ISY1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ISY1 About    
    See pathways by source

    SuperPathContained pathways About
    1Spliceosome
    Spliceosome

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for ISY1):
        Spliceosome


    ISY1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISY1
    Interactions:

        Search GeneGlobe Interaction Network for ISY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ISY1 (Q9ULR01, 2, 3 ENSP000003769734) via UniProtKB, MINT, STRING, and/or I2D (see all 150)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XAB2Q9HCS71, 2, 3, ENSP000003511374EBI-2557660,EBI-295232 MINT-8337046 MINT-8331954 I2D: score=1 STRING: ENSP00000351137
    DHX8Q145621, 2, ENSP000002624154EBI-2557660,EBI-2511477 MINT-8331569 MINT-8337123 STRING: ENSP00000262415
    SRRM1Q8IYB33, ENSP000003262614I2D: score=1 STRING: ENSP00000326261
    ISY1Q9ULR02MINT-8337112
    HNRNPA1L2ENSP000003412854STRING: ENSP00000350090 STRING: ENSP00000341285
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome IC11991638

    ISY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISY1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ISY1 gene (2 alternative transcripts): 
    NM_001199469.1  NM_020701.3  

    Unigene Cluster for ISY1:

    ISY1 splicing factor homolog (S. cerevisiae)
    Hs.512661  [show with all ESTs]
    Unigene Representative Sequence: NM_001204890
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393295(uc010hsz.2 uc010hta.2 uc003elp.2) ENST00000471497
    ENST00000273541 ENST00000471306 ENST00000496163 ENST00000393292 ENST00000485703

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ISY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISY1 (see all 9):
    hsa-miR-485-5p hsa-miR-3163 hsa-miR-548p hsa-miR-888 hsa-miR-519e* hsa-miR-211 hsa-miR-515-5p hsa-miR-204
    SwitchGear 3'UTR luciferase reporter plasmidISY1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ISY1
    Predesigned siRNA for gene silencing in human, mouse, rat ISY1
    Clone
    Products:
         
    OriGene clones in human, mouse for ISY1 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISY1 (NM_020701)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISY1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ISY1
    OriGene qSTAR qPCR primer pairs in human, mouse for ISY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISY1
      QuantiTect SYBR Green Assays in human, mouse, rat ISY1
      QuantiFast Probe-based Assays in human, mouse, rat ISY1

    Additional mRNA sequence: 

    AK024035.1 BC004122.2 BC004442.1 BC007409.2 BC019849.1 HQ013244.1 

    16 DOTS entries:

    DT.456025  DT.100038093  DT.120862682  DT.92418662  DT.95229920  DT.100798218  DT.100690515  DT.100798230 
    DT.100679481  DT.100689789  DT.100038095  DT.95350688  DT.97851543  DT.120690482  DT.120916639  DT.87016444 

    Selected AceView cDNA sequences (see all 393):

    BE909025 BQ675818 CR607147 AW150689 BC004442 BQ053774 AK024035 AL043994 
    BQ052432 BX418603 CR614909 NM_020701 BE550022 BE859083 BC062319 BQ641848 
    AI696821 AW513174 BQ069284 BM984704 BG751105 AW129926 AW247894 BC004122 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ISY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGACCGGAG
    ISY1 Expression
    About this image

    ISY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512661
        Custom PCR Arrays for ISY1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ISY1
    OriGene qSTAR qPCR primer pairs in human, mouse for ISY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISY1
    QuantiTect SYBR Green Assays in human, mouse, rat ISY1
    QuantiFast Probe-based Assays in human, mouse, rat ISY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ISY1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    78(a)
    1 → many
    12(5051630-5061707)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    1 → many
    2(159117262-159161392)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.194642 Xenopus laevis transcribed sequence with weak similarity more 76.38(n)    BJ635570.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab436
    RAB43, member RAS oncogene family
    81(a)
    1 → many
    11(461198-473297) ENSDARG00000063466
    fruit fly
    (Drosophila melanogaster)
    Insecta CG96676
    --
    60(a)
    1 → many
    3R(3951009-3952055)
    worm
    (Caenorhabditis elegans)
    Secernentea F53B7.36
    Protein F53B7.3 (F53B7.3) mRNA, complete cds
    49(a)
    1 → many
    V(10999425-11000792) WBGene00009966
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISY16
    Member of NineTeen Complex (NTC) that contains Prp...
    30(a)
    1 → many
    X(528697-529404) YJR050W
            Species with no ortholog for ISY1

    ENSEMBL Gene Tree for ISY1 (if available)
    TreeFam Gene Tree for ISY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ISY1 gene
    ISY1-RAB432  
    1 SIMAP similar gene for ISY1 using alignment to 4 protein entries:     ISY1_HUMAN (see all proteins):
    ISY1-RAB43

    ISY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ISY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725900CNV Deletion23290073
    dgv5251n71CNV Loss21882294
    nsv877471CNV Loss21882294
    dgv5252n71CNV Loss21882294
    dgv5253n71CNV Gain+Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISY1
    DNA2.0 Custom Variant and Variant Library Synthesis for ISY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612764    OMIM disorders: --


    ISY1 for disorders           About GeneDecksing


    Export disorders for ISY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ISY1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ISY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. (PubMed id 16103217)1, 3 Villa T. and Guthrie C. (amp 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PubMed id 11991638)1, 2 Jurica M.S.... Moore M.J. (RNA 2002)
    4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    5. Dynamic protein-protein interaction wiring of the human spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (Mol. Cell 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (Sci Signal 2009)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57461 HGNC: 29201 AceView: KIAA1160andRAB43 Ensembl:ENSG00000240682 euGenes: HUgn57461
    ECgene: ISY1 Kegg: 57461 H-InvDB: ISY1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1160

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ISY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ISY1 gene:
    Search GeneIP for patents involving ISY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ISY1  
     OriGene qPCR primer pairs and template standards for ISY1   OriGene Protein Over-expression Lysate for ISY1  
     OriGene MassSpec something-or-other for ISY1   OriGene clones in human, mouse for ISY1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ISY1   OriGene Purified Protein for ISY1  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ISY1   OriGene Custom Protein Services for ISY1  

     
     
     Block miRNA regulation of human, mouse, rat ISY1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ISY1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISY1 Predesigned siRNA for gene silencing in human, mouse, rat ISY1
     QuantiFast Probe-based Assays in human, mouse, rat ISY1 QuantiTect SYBR Green Assays in human, mouse, rat ISY1
     Custom PCR Arrays for ISY1 Search Chromatin IP Primers for ISY1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISY1  Search GeneGlobe Interaction Network for ISY1
     Regulatory tfbs in ISY1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ISY1 GenScript cDNA clones with any tag delivered in your preferred vector for ISY1
     GenScript Custom Assay Services for ISY1 GenScript Custom overexpressing Cell Line Services for ISY1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ISY1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ISY1 antibodies
     ISY1 proteins
     ISY1 lysates
     Antibodies for ISY1
     See all of Abcam's Antibodies, Kits and Proteins for ISY1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ISY1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISY1
     SwitchGear 3'UTR luciferase reporter plasmids for ISY1
     SwitchGear Promoter luciferase reporter plasmids for ISY1
     Search ThermoFisher Antibodies for ISY1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISY1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISY1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ISY1
     Search LSBio for Antibodies for ISY1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ISY1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4