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Aliases for ISY1 Gene

Aliases for ISY1 Gene

  • ISY1 Splicing Factor Homolog 2 3 5
  • Functional Spliceosome-Associated Protein 33 2 3
  • ISY1 Splicing Factor Homolog (S. Cerevisiae) 2
  • KIAA1160 4
  • FSAP33 3

External Ids for ISY1 Gene

Previous GeneCards Identifiers for ISY1 Gene

  • GC03M130292
  • GC03M128846
  • GC03M126234

Summaries for ISY1 Gene

GeneCards Summary for ISY1 Gene

ISY1 (ISY1 Splicing Factor Homolog) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and mRNA Splicing - Major Pathway. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is ISY1-RAB43.

UniProtKB/Swiss-Prot for ISY1 Gene

  • May play a role in pre-mRNA splicing.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISY1 Gene

Genomics for ISY1 Gene

Regulatory Elements for ISY1 Gene

Promoters for ISY1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ISY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ISY1 Gene

Chromosome:
3
Start:
129,127,415 bp from pter
End:
129,161,293 bp from pter
Size:
33,879 bases
Orientation:
Minus strand

Genomic View for ISY1 Gene

Genes around ISY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISY1 Gene

Proteins for ISY1 Gene

  • Protein details for ISY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULR0-ISY1_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor ISY1 homolog
    Protein Accession:
    Q9ULR0
    Secondary Accessions:
    • Q96IL2
    • Q9BT05

    Protein attributes for ISY1 Gene

    Size:
    285 amino acids
    Molecular mass:
    32992 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Component of the XAB2 complex, a multimeric protein complex composed of XAB2, PRPF19, AQR, ZNF830, ISY1, and PPIE.
    SequenceCaution:
    • Sequence=BAA86474.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ISY1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ISY1 Gene

Proteomics data for ISY1 Gene at MOPED

Post-translational modifications for ISY1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISY1 Gene

No data available for DME Specific Peptides for ISY1 Gene

Domains & Families for ISY1 Gene

Protein Domains for ISY1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ISY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9ULR0

UniProtKB/Swiss-Prot:

ISY1_HUMAN :
  • Belongs to the ISY1 family.
Family:
  • Belongs to the ISY1 family.
genes like me logo Genes that share domains with ISY1: view

No data available for Gene Families for ISY1 Gene

Function for ISY1 Gene

Molecular function for ISY1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in pre-mRNA splicing.

Gene Ontology (GO) - Molecular Function for ISY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000384 contributes_to first spliceosomal transesterification activity IBA --
genes like me logo Genes that share ontologies with ISY1: view
genes like me logo Genes that share phenotypes with ISY1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISY1 Gene

Localization for ISY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISY1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISY1 Gene COMPARTMENTS Subcellular localization image for ISY1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ISY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ISY1: view

Pathways & Interactions for ISY1 Gene

genes like me logo Genes that share pathways with ISY1: view

Gene Ontology (GO) - Biological Process for ISY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000389 mRNA 3-splice site recognition IBA --
GO:0000398 mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with ISY1: view

No data available for SIGNOR curated interactions for ISY1 Gene

Drugs & Compounds for ISY1 Gene

No Compound Related Data Available

Transcripts for ISY1 Gene

Unigene Clusters for ISY1 Gene

ISY1 splicing factor homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISY1 Gene

No ASD Table

Relevant External Links for ISY1 Gene

GeneLoc Exon Structure for
ISY1
ECgene alternative splicing isoforms for
ISY1

Expression for ISY1 Gene

mRNA expression in normal human tissues for ISY1 Gene

Protein differential expression in normal tissues from HIPED for ISY1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Testis (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISY1 Gene



SOURCE GeneReport for Unigene cluster for ISY1 Gene Hs.512661

genes like me logo Genes that share expression patterns with ISY1: view

Protein tissue co-expression partners for ISY1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ISY1 Gene

Orthologs for ISY1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISY1 35
  • 99.67 (n)
  • 99.67 (a)
cow
(Bos Taurus)
Mammalia ISY1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ISY1 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Isy1 36
  • 98 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 78 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76019 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.19464 35
zebrafish
(Danio rerio)
Actinopterygii rab43 36
  • 81 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9667 36
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F53B7.3 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISY1 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2201 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for ISY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ISY1 Gene

ENSEMBL:
Gene Tree for ISY1 (if available)
TreeFam:
Gene Tree for ISY1 (if available)

Paralogs for ISY1 Gene

Paralogs for ISY1 Gene

(1) SIMAP similar genes for ISY1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ISY1: view

Variants for ISY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ISY1 Gene

Variant ID Type Subtype PubMed ID
dgv5251n71 CNV Loss 21882294
dgv5252n71 CNV Loss 21882294
nsv877471 CNV Loss 21882294
dgv5253n71 CNV Gain+Loss 21882294
esv2725900 CNV Deletion 23290073

Variation tolerance for ISY1 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISY1 Gene

HapMap Linkage Disequilibrium report
ISY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ISY1 Gene

Disorders for ISY1 Gene

Relevant External Links for ISY1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISY1

No disorders were found for ISY1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISY1 Gene

Publications for ISY1 Gene

  1. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. (PMID: 16103217) Villa T. … Guthrie C. (Genes Dev. 2005) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Dynamic protein-protein interaction wiring of the human spliceosome. (PMID: 22365833) Hegele A. … Stelzl U. (Mol. Cell 2012) 3

Products for ISY1 Gene

Sources for ISY1 Gene

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