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Aliases for ISX Gene

Aliases for ISX Gene

  • Intestine Specific Homeobox 2 3 5
  • Intestine-Specific Homeobox 2 3
  • RAX-Like Homeobox 3 4
  • RAXLX 3 4
  • Pancreas-Intestine Homeodomain Transcription Factor 3
  • Pix-1 3

External Ids for ISX Gene

Previous GeneCards Identifiers for ISX Gene

  • GC22P033792
  • GC22P035462
  • GC22P018424

Summaries for ISX Gene

Entrez Gene Summary for ISX Gene

  • Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the RAXLX homeobox gene family. [provided by RefSeq, Jul 2008]

GeneCards Summary for ISX Gene

ISX (Intestine Specific Homeobox) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is RAX.

UniProtKB/Swiss-Prot for ISX Gene

  • Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISX Gene

Genomics for ISX Gene

Regulatory Elements for ISX Gene

Enhancers for ISX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G035133 1.3 FANTOM5 ENCODE dbSUPER 2 +68.8 68762 2.2 TBL1XR1 TAL1 ZSCAN4 EBF1 ZIC2 ZKSCAN1 TCF12 NCOR1 NR2F6 NRF1 LINC01399 ISX GC22P035126 ENSG00000279184
GH22G035064 0.9 ENCODE 0.7 +0.7 686 4.7 HDAC1 ELF3 PKNOX1 FOXA2 YBX1 ZNF366 RELB IKZF2 CREM MIXL1 HMGXB4 ISX-AS1 ISX GC22P035086
GH22G035071 0.6 ENCODE 0.4 +5.9 5865 0.6 ZNF680 MAX NR3C1 NR2F2 POLR2A SMARCA4 ZFX HNRNPL ISX-AS1 ISX GC22P035086
GH22G035024 0.7 ENCODE 0.3 -42.0 -41952 0.1 CTCF ZNF654 TBL1XR1 RB1 NRF1 IRF3 TRIM22 ZNF223 MIER2 REST ISX-AS1 ISX
GH22G035047 0.5 FANTOM5 0.4 -18.7 -18661 0.2 POLR2A RELA ISX-AS1 TOM1 HMOX1 ISX
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ISX on UCSC Golden Path with GeneCards custom track

Genomic Location for ISX Gene

Chromosome:
22
Start:
35,066,136 bp from pter
End:
35,087,387 bp from pter
Size:
21,252 bases
Orientation:
Plus strand

Genomic View for ISX Gene

Genes around ISX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISX Gene

Proteins for ISX Gene

  • Protein details for ISX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M1V0-ISX_HUMAN
    Recommended name:
    Intestine-specific homeobox
    Protein Accession:
    Q2M1V0
    Secondary Accessions:
    • Q68DJ5

    Protein attributes for ISX Gene

    Size:
    245 amino acids
    Molecular mass:
    27011 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISX Gene

Post-translational modifications for ISX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISX Gene

Domains & Families for ISX Gene

Gene Families for ISX Gene

Protein Domains for ISX Gene

Suggested Antigen Peptide Sequences for ISX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ISX: view

No data available for UniProtKB/Swiss-Prot for ISX Gene

Function for ISX Gene

Molecular function for ISX Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine (By similarity).

Gene Ontology (GO) - Molecular Function for ISX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ISX: view
genes like me logo Genes that share phenotypes with ISX: view

Animal Models for ISX Gene

MGI Knock Outs for ISX:

Animal Model Products

CRISPR Products

miRNA for ISX Gene

miRTarBase miRNAs that target ISX

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ISX

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ISX Gene

Localization for ISX Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISX gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ISX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ISX: view

Pathways & Interactions for ISX Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:1901738 regulation of vitamin A metabolic process IEA --
genes like me logo Genes that share ontologies with ISX: view

No data available for Pathways by source and SIGNOR curated interactions for ISX Gene

Drugs & Compounds for ISX Gene

No Compound Related Data Available

Transcripts for ISX Gene

mRNA/cDNA for ISX Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ISX Gene

Intestine-specific homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ISX

Alternative Splicing Database (ASD) splice patterns (SP) for ISX Gene

No ASD Table

Relevant External Links for ISX Gene

GeneLoc Exon Structure for
ISX
ECgene alternative splicing isoforms for
ISX

Expression for ISX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISX Gene

This gene is overexpressed in Colon - Transverse (x33.8) and Small Intestine - Terminal Ileum (x16.7).

NURSA nuclear receptor signaling pathways regulating expression of ISX Gene:

ISX

SOURCE GeneReport for Unigene cluster for ISX Gene:

Hs.567637

Evidence on tissue expression from TISSUES for ISX Gene

  • Intestine(2.4)
genes like me logo Genes that share expression patterns with ISX: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISX Gene

Orthologs for ISX Gene

This gene was present in the common ancestor of animals.

Orthologs for ISX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISX 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia ISX 34 35
  • 79.89 (n)
cow
(Bos Taurus)
Mammalia ISX 34 35
  • 78.27 (n)
rat
(Rattus norvegicus)
Mammalia Isx 34
  • 72.54 (n)
mouse
(Mus musculus)
Mammalia Isx 34 16 35
  • 72.52 (n)
oppossum
(Monodelphis domestica)
Mammalia ISX 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves ISX 34 35
  • 59.39 (n)
lizard
(Anolis carolinensis)
Reptilia ISX 35
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rx1 35
  • 22 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11294 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
Species where no ortholog for ISX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISX Gene

ENSEMBL:
Gene Tree for ISX (if available)
TreeFam:
Gene Tree for ISX (if available)

Paralogs for ISX Gene

Paralogs for ISX Gene

(2) SIMAP similar genes for ISX Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ISX: view

Variants for ISX Gene

Sequence variations from dbSNP and Humsavar for ISX Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000020131 -- 35,082,968(+) ATGCA(A/G)CCTCA intron-variant
rs1000240302 -- 35,086,906(+) CCTCT(C/T)GCACA utr-variant-3-prime
rs1000507135 -- 35,076,993(+) CTTCT(C/T)GGCTT intron-variant
rs1000831719 -- 35,071,008(+) GTCAG(G/T)CCAGA intron-variant
rs1000967032 -- 35,071,218(+) GCCAT(G/T)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ISX Gene

Variant ID Type Subtype PubMed ID
esv2661366 CNV deletion 23128226
esv26909 CNV gain 19812545
esv2758835 CNV loss 17122850
esv28292 CNV loss 19812545
esv34121 CNV loss 18971310
esv35003 CNV loss 17911159
esv3584500 CNV gain 24956385
esv3647659 CNV loss 21293372
nsv1118076 CNV deletion 24896259
nsv817989 CNV loss 17921354
nsv820628 CNV duplication 20802225
nsv834182 CNV gain 17160897
nsv834183 CNV gain 17160897

Variation tolerance for ISX Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ISX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISX Gene

Disorders for ISX Gene

Relevant External Links for ISX

Genetic Association Database (GAD)
ISX
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISX

No disorders were found for ISX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISX Gene

Publications for ISX Gene

  1. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. (PMID: 23393141) Lobo G.P. … von Lintig J. (J. Biol. Chem. 2013) 3 64
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64
  3. Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma. (PMID: 23221382) Hsu S.H. … Wang S.N. (Cancer Res. 2013) 3 64
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3 64
  5. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disease. (PMID: 20622878) Remmers E.F. … GA1l A. (Nat. Genet. 2010) 46 64

Products for ISX Gene

  • Addgene plasmids for ISX

Sources for ISX Gene

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