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ISX Gene

protein-coding   GIFtS: 46
GCID: GC22P035462

Intestine-Specific Homeobox

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Intestine-Specific Homeobox1 2
RAXLX2 3 5
RAX-Like Homeobox2 3
Pix-12
Pancreas-Intestine Homeodomain Transcription Factor2

External Ids:    HGNC: 280841   Entrez Gene: 914642   Ensembl: ENSG000001753297   OMIM: 6120195   UniProtKB: Q2M1V03   

Export aliases for ISX gene to outside databases

Previous GC identifers: GC22P033792 GC22P018424


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ISX Gene:
Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic
development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain.
This gene is a member of the RAXLX homeobox gene family. (provided by RefSeq, Jul 2008)

GeneCards Summary for ISX Gene:
ISX (intestine-specific homeobox) is a protein-coding gene. Diseases associated with ISX include red color blindness, and red-green color blindness. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ALX1.

UniProtKB/Swiss-Prot: ISX_HUMAN, Q2M1V0
Function: Transcription factor that regulates gene expression in intestine. May participate in vitamin A
metabolism most likely by regulating BCMO1 expression in the intestine (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ISX
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISX promoter sequence
   Search Chromatin IP Primers for ISX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.3   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q12.3

ISX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISX gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P035462:  view genomic region     (about GC identifiers)

Start:
35,462,129 bp from pter      End:
35,483,380 bp from pter
Size:
21,252 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ISX_HUMAN, Q2M1V0 (See protein sequence)
Recommended Name: Intestine-specific homeobox  
Size: 245 amino acids; 27011 Da
Secondary accessions: Q68DJ5

Explore the universe of human proteins at neXtProt for ISX: NX_Q2M1V0

Explore proteomics data for ISX at MOPED


See ISX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001008494.1  
ENSEMBL proteins: 
 ENSP00000386037   ENSP00000311492  

ISX Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for ISX
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Cloud-Clone Corp. Proteins for ISX

ISX Antibody Products:

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Novus Biologicals ISX Antibody
Abcam antibodies for ISX
Cloud-Clone Corp. Antibodies for ISX
Search ThermoFisher Antibodies for ISX
LSBio Antibodies in human, mouse, rat for ISX

ISX Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for ISX
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for ISX
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for ISX
Cloud-Clone Corp. CLIAs for ISX


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

3 InterPro protein domains:
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q2M1V0

ProtoNet protein and cluster: Q2M1V0

UniProtKB/Swiss-Prot: ISX_HUMAN, Q2M1V0
Similarity: Contains 1 homeobox DNA-binding domain


ISX for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ISX_HUMAN, Q2M1V0
Function: Transcription factor that regulates gene expression in intestine. May participate in vitamin A
metabolism most likely by regulating BCMO1 expression in the intestine (By similarity)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
ISX for ontologies           About GeneDecksing


Phenotypes:
     2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Isx):
 no phenotypic analysis  normal 

ISX for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Isxtm1Shiv for ISX

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISX
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ISX

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISX
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISX

miRNA
Products:
    
miRTarBase miRNAs that target ISX:
hsa-mir-3928-3p (MIRT052890)

Block miRNA regulation of human, mouse, rat ISX using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ISX (see all 10):
hsa-miR-222* hsa-miR-198 hsa-miR-516b* hsa-miR-520a-5p hsa-miR-3125 hsa-miR-3916 hsa-miR-525-5p hsa-miR-377
SwitchGear 3'UTR luciferase reporter plasmidISX 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for ISX
Predesigned siRNA for gene silencing in human, mouse, rat ISX

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for ISX

Clone
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OriGene clones in human, mouse for ISX (see all 6)
OriGene ORF clones in mouse, rat for ISX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ISX (NM_001008494)
Sino Biological Human cDNA Clone for ISX
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISX

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for ISX
Browse ESI BIO Cell Lines and PureStem Progenitors for ISX 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISX


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ISX_HUMAN, Q2M1V0: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

ISX for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISX
Interactions:

    Search GeneGlobe Interaction Network for ISX

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for ISX (ENSP000003114924) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CHEK2ENSP000003720234STRING: ENSP00000372023
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Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0006357regulation of transcription from RNA polymerase II promoter IEA--
GO:1901738regulation of vitamin A metabolic process IEA--

ISX for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ISX



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ISX gene: 
NM_001008494.1  

Unigene Cluster for ISX:

Intestine-specific homeobox
Hs.567637  [show with all ESTs]
Unigene Representative Sequence: CR749372
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000404699 ENST00000308700(uc003anj.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat ISX using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate ISX (see all 10):
hsa-miR-222* hsa-miR-198 hsa-miR-516b* hsa-miR-520a-5p hsa-miR-3125 hsa-miR-3916 hsa-miR-525-5p hsa-miR-377
SwitchGear 3'UTR luciferase reporter plasmidISX 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ISX
Predesigned siRNA for gene silencing in human, mouse, rat ISX
Clone
Products:
     
OriGene clones in human, mouse for ISX (see all 6)
OriGene ORF clones in mouse, rat for ISX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ISX (NM_001008494)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISX
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ISX
OriGene qSTAR qPCR primer pairs in human, mouse for ISX
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISX
  QuantiTect SYBR Green Assays in human, mouse, rat ISX
  QuantiFast Probe-based Assays in human, mouse, rat ISX

Additional mRNA sequence: 

AB219123.1 AK025181.1 BC112212.1 BC113633.1 CR749372.1 

1 DOTS entry:

DT.86846622 

9 AceView cDNA sequences:

BQ649633 AA005235 AW295293 AK025181 CR749372 BF592756 AW293791 AA564263 
AA005236 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ISX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAATATGCCA
ISX Expression
About this image


ISX expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 NULL (Uncategorized)
         Endoderm progenitor-like cells
ISX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ISX Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.567637
    Custom PCR Arrays for ISX
Primer
Products:
OriGene qPCR primer pairs and template standards for ISX
OriGene qSTAR qPCR primer pairs in human, mouse for ISX
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISX
QuantiTect SYBR Green Assays in human, mouse, rat ISX
QuantiFast Probe-based Assays in human, mouse, rat ISX
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISX

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ISX gene from 11 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia ISX1 intestine-specific homeobox 99.05(n)
98.78(a)
  739804  XM_001154843.1  XP_001154843.1 
mouse
(Mus musculus)
Mammalia Isx1 , 5 intestine specific homeobox1, 5 72.52(n)1
64.44(a)1
  8 (35.54 cM)5
715971  NM_027837.31  NP_082113.21 
 748727195 
rat
(Rattus norvegicus)
Mammalia Isx1 intestine-specific homeobox 72.54(n)
66.96(a)
  682968  XM_006255147.1  XP_006255209.1 
cow
(Bos taurus)
Mammalia ISX1 intestine-specific homeobox 78.27(n)
68.72(a)
  506388  XM_003586097.2  XP_003586145.1 
dog
(Canis familiaris)
Mammalia ISX1 intestine-specific homeobox 79.89(n)
71.55(a)
  610571  XM_848103.2  XP_853196.2 
oppossum
(Monodelphis domestica)
Mammalia ISX6
intestine-specific homeobox
46(a)
1 ↔ 1
8(89706949-89735016)
chicken
(Gallus gallus)
Aves ISX1 intestine-specific homeobox 59.39(n)
48.85(a)
  418060  XM_004937799.1  XP_004937856.1 
lizard
(Anolis carolinensis)
Reptilia ISX6
intestine-specific homeobox
64(a)
1 ↔ 1
5(21254767-21257820)
zebrafish
(Danio rerio)
Actinopterygii rx16
retinal homeobox gene 1
22(a)
many ↔ many
22(4640467-4648012) ENSDARG00000071684
sea squirt
(Ciona savignyi)
Ascidiacea --
Uncharacterized protein
50(a)
1 ↔ 1
reftig_337(131452-132573)
fruit fly
(Drosophila melanogaster)
Insecta CG112946
--
20(a)
1 ↔ 1
X(8585852-8587587)
        Species with no ortholog for ISX

ENSEMBL Gene Tree for ISX (if available)
TreeFam Gene Tree for ISX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ISX gene
ALX12  PHOX2B2  ARX2  RAX2  DRGX2  SHOX22  PRRX12  PHOX2A2  
ALX42  RAX22  ALX32  SHOX2  OTP2  PRRX22  
2 SIMAP similar genes for ISX using alignment to 1 protein entry:     ISX_HUMAN:
Pix-1    RAX2

ISX for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ISX (see all 610)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1473239791,2
Cuntested119384907(+) GCCCCA/GAAGAA 2 P syn10--------
rs718667851,2
C--18437169(+) CCACA-/ATAGTGAG 1 -- int10--------
rs2004288481,2
C--19381991(+) AACAA-/AGGTGT 1 -- us2k10--------
rs1875068021,2
--19382103(+) GAGGTA/GCAGAG 1 -- us2k10--------
rs3621981,2
C,F,A--19382122(-) CAAACC/TCAGGT 1 -- us2k16Minor allele frequency- T:0.27NA WA 130
rs3619841,2
C,F--19382277(-) GCTGGG/ACCTCG 1 -- us2k19Minor allele frequency- A:0.15NA WA CSA EA 369
rs1397972141,2
--19382301(+) TCCATC/TGCCTC 1 -- us2k10--------
rs3618901,2
C,F--19382379(-) TCTGAG/TGGGTA 1 -- us2k19Minor allele frequency- T:0.34NA WA CSA EA 370
rs731680441,2
C,F--19382389(+) AGCTTC/TCTCTG 1 -- us2k11Minor allele frequency- T:0.01NA 120
rs104276771,2
C,F,A,H--19382405(+) AGTGTA/CAGGAA 1 -- us2k132Minor allele frequency- C:0.17NA NS EA WA CSA 3322

HapMap Linkage Disequilibrium report for ISX (35462129 - 35483380 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ISX (see all 11):    About this table    
Variant IDTypeSubtypePubMed ID
esv2661366CNV Deletion23128226
nsv820628CNV Duplication20802225
esv28292CNV Loss19812545
nsv817989CNV Loss17921354
esv35003CNV Loss17911159
esv34121CNV Loss18971310
esv26909CNV Gain19812545
nsv834182CNV Gain17160897
nsv834183CNV Gain17160897
essv7049CNV CNV17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ISX
DNA2.0 Custom Variant and Variant Library Synthesis for ISX

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612019    OMIM disorders: --

8 diseases for ISX:    
About MalaCards
red color blindness    red-green color blindness    actinomycosis    color blindness
intestinal obstruction    blindness    retinitis    hepatocellular carcinoma


ISX for disorders           About GeneDecksing

Genetic Association Database (GAD): ISX

Export disorders for ISX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ISX gene integrated from 10 sources:
(articles sorted by number of sources associating them with ISX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
  2. Proinflammatory homeobox gene, ISX, regulates tumor growth and survival in hepatocellular carcinoma. (PubMed id 23221382)1 Hsu S.H....Wang S.N. (Cancer Res. 2013)
  3. Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX. (PubMed id 23393141)1 Lobo G.P....von Lintig J. (J. Biol. Chem. 2013)
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  5. Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with BehAset's disease. (PubMed id 20622878)4 Remmers E.F....GA1l A. (Nat. Genet. 2010)
  6. Isx participates in the maintenance of vitamin A metabolism by regulation of beta-carotene 15,15'-monooxygenase (Bcmo1) expression. (PubMed id 18093975)1 Seino Y.... Seino S. (J. Biol. Chem. 2008)
  7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I.... Wright H. (Nature 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 91464 HGNC: 28084 AceView: LOC91464 Ensembl:ENSG00000175329 euGenes: HUgn91464
ECgene: ISX H-InvDB: ISX

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ISX Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ISX gene:
Search GeneIP for patents involving ISX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ISX  
 OriGene qPCR primer pairs and template standards for ISX   OriGene Protein Over-expression Lysate for ISX  
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 OriGene qSTAR qPCR primer pairs in human, mouse for ISX   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
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 Block miRNA regulation of human, mouse, rat ISX using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ISX
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISX Predesigned siRNA for gene silencing in human, mouse, rat ISX
 QuantiFast Probe-based Assays in human, mouse, rat ISX QuantiTect SYBR Green Assays in human, mouse, rat ISX
 Custom PCR Arrays for ISX Search Chromatin IP Primers for ISX
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISX  Search GeneGlobe Interaction Network for ISX
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 GenScript Custom Purified and Recombinant Proteins Services for ISX GenScript cDNA clones with any tag delivered in your preferred vector for ISX
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 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
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 Search Tocris compounds for ISX
 Browse Sino Biological Proteins
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 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
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 See all of Abcam's Antibodies, Kits and Proteins for ISX
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 Browse ESI BIO Cell Lines and PureStem Progenitors for ISX
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISX
 SwitchGear 3'UTR luciferase reporter plasmids for ISX
 SwitchGear Promoter luciferase reporter plasmids for ISX
 Search ThermoFisher Antibodies for ISX
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISX
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISX
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ISX
 LSBio Antibodies in human, mouse, rat for ISX
Customized transgenic rodents for:
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 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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