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IST1 Gene

protein-coding   GIFtS: 51
GCID: GC16P071881

Increased Sodium Tolerance 1 Homolog (Yeast)

(Previous name: KIAA0174)
(Previous symbol: KIAA0174)
  See IST1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Increased Sodium Tolerance 1 Homolog (Yeast)1 2     Overexpressed In Lung Cancer 12
KIAA01741 3     hIST13
Putative MAPK-Activating Protein PM282 3     D5
OLC12     IRHOM15
IST1 Homolog2     RHBDF15

External Ids:    HGNC: 289771   Entrez Gene: 97982   Ensembl: ENSG000001821497   OMIM: 6144035   UniProtKB: P539903   

Export aliases for IST1 gene to outside databases

Previous GC identifer: GC16P071930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IST1 Gene:
This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting
complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during
membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for IST1 Gene:
IST1 (increased sodium tolerance 1 homolog (yeast)) is a protein-coding gene. Diseases associated with IST1 include lung cancer. GO annotations related to this gene include MIT domain binding and protein domain specific binding.

UniProtKB/Swiss-Prot: IST1_HUMAN, P53990
Function: Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient
abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established.
Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells

Gene Wiki entry for IST1 (KIAA0174) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for IST1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIST1 promoter sequence
   Search Chromatin IP Primers for IST1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q22.2   HGNC cytogenetic band: 16q22.2

IST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IST1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P071881:  view genomic region     (about GC identifiers)

Start:
71,879,899 bp from pter      End:
71,962,913 bp from pter
Size:
83,015 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IST1_HUMAN, P53990 (See protein sequence)
Recommended Name: IST1 homolog  
Size: 364 amino acids; 39751 Da
Subunit: Interacts with CHMP1A, CHMP1B, VPS4A and VTA1. Interacts with SPAST, STAMBP, and USP8. May interact with
VPS37B. May associate with the ESCRT-I complex. Interacts with MITD1, in competition with VSP4
Sequence caution: Sequence=BAA11491.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for IST1:
3FRR (3D)        3FRS (3D)    
Secondary accessions: A8KAH5 Q3SYM4 Q9BQ81 Q9BWN2
Alternative splicing: 5 isoforms:  P53990-1   P53990-2   P53990-5   P53990-4   P53990-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for IST1: NX_P53990

Explore proteomics data for IST1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys118
  • Modification sites at PhosphoSitePlus

  • See IST1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001257904.1  NP_001257905.1  NP_001257906.1  NP_001257907.1  NP_001257908.1  NP_055576.2  

    ENSEMBL proteins: 
     ENSP00000456200   ENSP00000455409   ENSP00000457844   ENSP00000455860   ENSP00000455590  
     ENSP00000368076   ENSP00000457646   ENSP00000398505   ENSP00000330408   ENSP00000463711  
     ENSP00000455805   ENSP00000454541   ENSP00000368075   ENSP00000455757   ENSP00000410081  
     ENSP00000414942   ENSP00000463833   ENSP00000438399   ENSP00000475853  

    IST1 Human Recombinant Protein Products:

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    antibodies-online proteins for IST1 (4 products) 

     
    antibodies-online peptides for IST1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005061 DUF292_euk

    Graphical View of Domain Structure for InterPro Entry P53990

    ProtoNet protein and cluster: P53990

    1 Blocks protein domain: IPB005061 Eukaryotic protein of unknown function DUF292

    UniProtKB/Swiss-Prot: IST1_HUMAN, P53990
    Similarity: Belongs to the IST1 family


    Find genes that share domains with IST1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IST1_HUMAN, P53990
    Function: Proposed to be involved in specific functions of the ESCRT machinery. Is required for efficient
    abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established.
    Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16713569
    GO:0019904protein domain specific binding IPI--
    GO:0032403protein complex binding IDA19129479
    GO:0090541MIT domain binding IPI19129479
         
    Find genes that share ontologies with IST1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IST1:
     Wnt reporter downregulated 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IST1

    miRNA
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    miRTarBase miRNAs that target IST1:
    hsa-mir-1 (MIRT023986)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IST1_HUMAN, P53990: Cytoplasmic vesicle. Note=Localizes to the midbody of dividing cells

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IDA10942595
    GO:0005813centrosome IDA19129479
    GO:0005829cytosol IDA19129480
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--
    GO:0030496midbody IDA19129479

    Find genes that share ontologies with IST1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IST1
    Interactions:

        Search GeneGlobe Interaction Network for IST1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IST1 (P539901, 2, 3 ENSP000003304084) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542531, 2, 3, ENSP000002447694EBI-945994,EBI-930964 MINT-2867558 MINT-2855184 I2D: score=3 STRING: ENSP00000244769
    CAPN7Q9Y6W31, 2, 3, ENSP000002536934EBI-945994,EBI-1765641 MINT-7990176 MINT-7990213 MINT-7990252 MINT-7990193 MINT-7990233 I2D: score=1 STRING: ENSP00000253693
    CALM1P621583I2D: score=4 
    CALM2P621583I2D: score=4 
    CALM3P621583I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IMP19129479
    GO:0008104protein localization IMP--
    GO:0009838abscission IMP19525971
    GO:0019076viral release from host cell IDA19129479
    GO:0045184establishment of protein localization IMP--

    Find genes that share ontologies with IST1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IST1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IST1 gene (6 alternative transcripts): 
    NM_001270975.1  NM_001270976.1  NM_001270977.1  NM_001270978.1  NM_001270979.1  NM_014761.3  

    Unigene Cluster for IST1:

    Increased sodium tolerance 1 homolog (yeast)
    Hs.232194  [show with all ESTs]
    Unigene Representative Sequence: NM_001270976
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000568581 ENST00000540296 ENST00000544564 ENST00000541571 ENST00000538104
    ENST00000378799(uc002fbj.1 uc010cgh.1 uc002fbm.1 uc002fbl.1)
    ENST00000537613 ENST00000424485 ENST00000566536 ENST00000538565(uc010vmk.1)
    ENST00000329908(uc002fbk.1) ENST00000538850 ENST00000541918 ENST00000534994
    ENST00000378798(uc010vml.1) ENST00000539186 ENST00000439924 ENST00000545518

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat IST1

    Additional mRNA sequence: 

    AB097052.1 AK057902.1 AK291388.1 AK293022.1 AK293040.1 AK295066.1 AK297088.1 AK297336.1 
    AK301918.1 AL355695.1 BC000116.1 BC000430.2 BC004359.1 BC038350.1 BC103745.1 D79996.1 

    Selected DOTS entries (see all 55):

    DT.453442  DT.95271280  DT.100698519  DT.91846874  DT.100870610  DT.100758626  DT.100032330  DT.95271282 
    DT.121497621  DT.120688087  DT.95271275  DT.100870621  DT.120688096  DT.95294600  DT.120688206  DT.100870601 
    DT.100038885  DT.120688165  DT.91778252  DT.120688117  DT.120688212  DT.100038887  DT.120688160  DT.99997907 

    Selected AceView cDNA sequences (see all 743):

    BI087431 BE797559 AU141901 BQ051104 BQ070997 BM793805 AL539540 BM694578 
    BM563631 BQ642605 BQ889071 BM464456 AW591568 BU161700 Z44478 T36148 
    AA564568 BQ439362 CB853490 BM838889 AU076791 BQ712315 BQ071159 BQ217342 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IST1 (see all 23)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c · 11d ^ 12a ·
    SP1:              -     -     -     -     -     -                 -                             -     -                       -                                 
    SP2:                                      -     -                 -                             -     -                       -                                 
    SP3:                                      -     -                 -                             -     -                       -                                 
    SP4:                                      -     -                 -                             -     -                       -                                 
    SP5:                                      -     -                 -                             -     -                       -                                 

    ExUns: 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c · 17d
    SP1:                                -     -                                 
    SP2:                                -     -                                 
    SP3:                                -     -                                 
    SP4:                    -     -     -     -                                 
    SP5:                                                                        


    ECgene alternative splicing isoforms for IST1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCTGTAGT
    IST1 Expression
    About this image

    IST1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IST1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.232194
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for IST1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ist11 , 5 RIKEN cDNA 2400003C14 gene5
    increased sodium tolerance 1 homolog (yeast)1
    89.96(n)1
    95.58(a)1
      8 (57.18 cM)5
    719551  NM_028018.21  NP_082294.11 
     1096713225 
    chicken
    (Gallus gallus)
    Aves IST11 increased sodium tolerance 1 homolog (yeast) 79.78(n)
    87.98(a)
      415877  XM_414234.4  XP_414234.2 
    lizard
    (Anolis carolinensis)
    Reptilia IST16
    increased sodium tolerance 1 homolog (yeast)
    80(a)
    1 ↔ 1
    GL343483.1(329183-335550)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.254312 Xenopus laevis transcribed sequence with strong similarity more 74.79(n)    48050902 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.11222 Danio rerio mRNA similar to KIAA0174 gene product (cDNA more 77.1(n)    BC045422.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101031 CG10103 55.21(n)
    53.91(a)
      38750  NM_001274555.1  NP_001261484.1 
    worm
    (Caenorhabditis elegans)
    Secernentea istr-16
    Protein K10C8.3, isoform a (K10C8.3) mRNA, complet...
    36(a)
    1 ↔ 1
    V(12697149-12704273) WBGene00010736
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IST1(YNL265C)4 Protein with a positive role in the multivesicular more   --   14(145281-144280) 855456  NP_014134.1 


    ENSEMBL Gene Tree for IST1 (if available)
    TreeFam Gene Tree for IST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IST1 gene

    Find genes that share paralogs with IST1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IST1
    PGOHUM00000234683


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IST1 (see all 875)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1431024821,2
    --71926326(+) CACCAA/CGCCCG 1 -- us2k10--------
    rs1816425541,2
    --71926337(+) GCTAAA/TTTTTT 1 -- us2k10--------
    rs1871124321,2
    --71926422(+) CGCCTC/TGGCCT 1 -- us2k10--------
    rs1138896381,2
    C,F--71926976(+) CACCCG/AGGCTG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs118637711,2
    C,F,H--71927008(+) gctcaC/Gtgcaa 1 -- us2k1 tfbs33Minor allele frequency- G:0.44NA WA CSA 9
    rs1163029571,2
    F--71927021(+) TCTATC/GTCCTG 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs98069051,2
    C,H--71927152(+) gtcttG/Catctc 1 -- us2k15Minor allele frequency- C:0.00NA CSA 11
    rs359891341,2
    C,F--71927411(+) AGGCTG/AGAGTG 6 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1895314911,2
    --71927448(+) ACCTCC/TGCCTC 6 -- us2k10--------
    rs1815939091,2
    --71927524(+) ACATCC/TGGCTA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for IST1 (71879899 - 71962913 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for IST1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1862CNV Insertion18451855
    nsv906893CNV Loss21882294
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IST1
    DNA2.0 Custom Variant and Variant Library Synthesis for IST1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614403    OMIM disorders: --

    1 disease for IST1:    
    About MalaCards
    lung cancer


    Find genes that share disorders with IST1           About GenesLikeMe


    Export disorders for IST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IST1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with IST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Essential role of hIST1 in cytokinesis. (PubMed id 19129480)1, 2, 3 Agromayor M.... Martin-Serrano J. (Mol. Biol. Cell 2009)
    2. Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8724849)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1996)
    3. Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2 Bajorek M....Sundquist W.I. (Mol. Biol. Cell 2009)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    8. Over-expression of the overexpressed in lung cancer-1 is associated with poor prognosis in colorectal cancer. (PubMed id 24403489)1 Liu J....Wang Y. (Anticancer Res. 2014)
    9. An ESCRT-spastin interaction promotes fission of recycling tubules from the endosome. (PubMed id 23897888)1 Allison R....Reid E. (J. Cell Biol. 2013)
    10. Over-expression of the overexpressed in lung cancer 1 is associated with poor prognosis in epithelial ovarian cancer. (PubMed id 23609236)1 Jia C....Sui L. (J Surg Oncol 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9798 HGNC: 28977 AceView: KIAA0174 Ensembl:ENSG00000182149 euGenes: HUgn9798
    ECgene: IST1 H-InvDB: IST1

    (According to HUGE)
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    HUGE: KIAA0174

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IST1 gene:
    Search GeneIP for patents involving IST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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