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ISPD Gene

protein-coding   GIFtS: 40
GCID: GC07M016098

Isoprenoid Synthase Domain Containing

  See ISPD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Isoprenoid Synthase Domain Containing1 2     4-Diphosphocytidyl-2C-Methyl-D-Erythritol Synthase Homolog2
Notch1-Induced Protein1 2     Nip2
2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase-Like Protein2 3     hCG_17451212
MDDGA72 5     Isoprenoid Synthase Domain-Containing Protein2
4-Diphosphocytidyl-2C-Methyl-D-Erythritol Synthase Homolog (Arabidopsis)1     EC 2.7.7.-3

External Ids:    HGNC: 372761   Entrez Gene: 7299202   Ensembl: ENSG000002149607   OMIM: 6146315   UniProtKB: A4D1263   

Export aliases for ISPD gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ISPD Gene:
This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene
are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. (provided
by RefSeq, May 2012)

GeneCards Summary for ISPD Gene:
ISPD (isoprenoid synthase domain containing) is a protein-coding gene. Diseases associated with ISPD include ispd-related muscle diseases, and muscular dystrophy-dystroglycanopathy , type a, 7. GO annotations related to this gene include nucleotidyltransferase activity.

UniProtKB/Swiss-Prot: ISPD_HUMAN, A4D126
Function: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in
synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ISPD
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ISPD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.2   Ensembl cytogenetic band:  7p21.2   HGNC cytogenetic band: 7p21.2

ISPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISPD gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M016098:  view genomic region     (about GC identifiers)

Start:
16,127,152 bp from pter      End:
16,460,947 bp from pter
Size:
333,796 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 16,180,240-16,514,081     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ISPD_HUMAN, A4D126 (See protein sequence)
Recommended Name: Isoprenoid synthase domain-containing protein  
Size: 451 amino acids; 49873 Da
Sequence caution: Sequence=EAL24288.1; Type=Erroneous gene model prediction;
Secondary accessions: A8MU35 H9KVB2
Alternative splicing: 2 isoforms:  A4D126-1   A4D126-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ISPD: NX_A4D126

Explore proteomics data for ISPD at MOPED


See ISPD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001094887.1  NP_001094896.1  

ENSEMBL proteins: 
 ENSP00000385478   ENSP00000382249  

ISPD Human Recombinant Protein Products:

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antibodies-online proteins for ISPD (3 products) 

 
antibodies-online peptides for ISPD

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antibodies-online antibodies for ISPD (10 products) 

ISPD Assay Products:

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antibodies-online kits for ISPD (3 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR001228 IspD
 IPR018294 ISPD_synthase_CS

Graphical View of Domain Structure for InterPro Entry A4D126

ProtoNet protein and cluster: A4D126

UniProtKB/Swiss-Prot: ISPD_HUMAN, A4D126
Similarity: Belongs to the IspD family


Find genes that share domains with ISPD           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ISPD_HUMAN, A4D126
Function: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in
synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation

     Enzyme Number (IUBMB): EC 2.7.7.-1

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0016779nucleotidyltransferase activity IEA--
     
Find genes that share ontologies with ISPD           About GenesLikeMe


Phenotypes:
     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ispd):
 cellular  mortality/aging  nervous system  other  respiratory system 

Find genes that share phenotypes with ISPD           About GenesLikeMe

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for ISPD

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ISPD (see all 13):
hsa-miR-142-5p hsa-miR-548w hsa-miR-548j hsa-miR-607 hsa-miR-559 hsa-miR-3135 hsa-miR-548i hsa-miR-548h
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
extracellular1
golgi apparatus1
mitochondrion1
nucleus1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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UniProtKB/Swiss-Prot: ISPD_HUMAN, A4D126
Pathway: Protein modification; protein glycosylation

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISPD
Interactions:

    Search GeneGlobe Interaction Network for ISPD

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006486protein glycosylation ----
GO:0007411axon guidance IEA--
GO:0008299isoprenoid biosynthetic process IEA--
GO:0035269protein O-linked mannosylation IMP--

Find genes that share ontologies with ISPD           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ISPD



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ISPD gene (2 alternative transcripts): 
NM_001101417.3  NM_001101426.3  

Unigene Cluster for ISPD:

Isoprenoid synthase domain containing
Hs.636502  [show with all ESTs]
Unigene Representative Sequence: NM_001101426
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000407010(uc010ktx.2) ENST00000399310(uc010kty.2) ENST00000479493

miRNA
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Selected qRT-PCR Assays for microRNAs that regulate ISPD (see all 13):
hsa-miR-142-5p hsa-miR-548w hsa-miR-548j hsa-miR-607 hsa-miR-559 hsa-miR-3135 hsa-miR-548i hsa-miR-548h
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ISPD
Predesigned siRNA for gene silencing in human, mouse, rat ISPD
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISPD
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ISPD
Primer
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISPD
  QuantiTect SYBR Green Assays in human, mouse, rat ISPD
  QuantiFast Probe-based Assays in human, mouse, rat ISPD

Additional mRNA sequence: AK124805.1 

5 DOTS entries:

DT.100689799  DT.91690171  DT.100739914  DT.101955795  DT.86857343 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ISPD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAACACAA
ISPD Expression
About this image

ISPD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ISPD Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.636502

UniProtKB/Swiss-Prot: ISPD_HUMAN, A4D126
Tissue specificity: Ubiquitously expressed, with high expression in brain

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QuantiFast Probe-based Assays in human, mouse, rat ISPD
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISPD

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ISPD gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ispd1 , 5 isoprenoid synthase domain containing1, 5 78.45(n)1
74.72(a)1
  12 (16.84 cM)5
758471  NM_178629.51  NP_848744.21 
 363815195 
chicken
(Gallus gallus)
Aves ISPD1 isoprenoid synthase domain containing 68.92(n)
61.35(a)
  420591  XM_004939331.1  XP_004939388.1 
lizard
(Anolis carolinensis)
Reptilia ISPD6
isoprenoid synthase domain containing
51(a)
1 ↔ 1
6(27315576-27384275)
tropical clawed frog
(Xenopus tropicalis)
Amphibia ispd1 isoprenoid synthase domain containing 65.12(n)
60.38(a)
  548994  NM_001016240.1  NP_001016240.1 
zebrafish
(Danio rerio)
Actinopterygii ispd1 isoprenoid synthase domain containing 55.63(n)
49.76(a)
  798716  NM_001077802.1  NP_001071270.1 


ENSEMBL Gene Tree for ISPD (if available)
TreeFam Gene Tree for ISPD (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ISPD gene

Find genes that share paralogs with ISPD           About GenesLikeMe


1 Pseudogenes.org Pseudogene for ISPD
PGOHUM00000239597


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ISPD (see all 7753)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0697414
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0697412 D N mis40--------
VAR_0697444
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0697442 T I mis40--------
VAR_0681034
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0681032 A D mis40--------
VAR_0697424
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0697422 M R mis40--------
VAR_0681014
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0681012 A P mis40--------
VAR_0697434
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0697432 Y H mis40--------
VAR_0681024
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7)4--see VAR_0681022 R H mis40--------
rs1387186021,2
C--16014195(+) GCATG-/TACA  
        
TACAT
2 -- ut310--------
rs355953881,2
C--16048937(+) TTTCT-/T/TT  
        
TTTTT
2 -- int11NA 2
rs16624911,2
C--16088103(+) tccatC/Ttcttc 2 -- int11Minor allele frequency- T:0.50NA 2

HapMap Linkage Disequilibrium report for ISPD (16127152 - 16377152 bp, first 250kb of ISPD)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ISPD (see all 44):    About this table    
Variant IDTypeSubtypePubMed ID
esv2734055CNV Deletion23290073
esv2734054CNV Deletion23290073
esv5024CNV Deletion18987735
nsv821416CNV Deletion20802225
esv2658278CNV Deletion23128226
esv2659119CNV Deletion23128226
esv2734052CNV Deletion23290073
esv2734053CNV Deletion23290073
esv2661402CNV Deletion23128226
dgv1185e199CNV Deletion23128226

Human Gene Mutation Database (HGMD): ISPD
Locus Specific Mutation Databases (LSDB): ISPD

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ISPD
DNA2.0 Custom Variant and Variant Library Synthesis for ISPD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614631   
OMIM disorders: 614643  
UniProtKB/Swiss-Prot: ISPD_HUMAN, A4D126
  • Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A7 (MDDGA7) [MIM:614643]:
    An autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone
    lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the
    first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe
    muscle-eye-brain disease. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for ISPD:    
    About MalaCards
    ispd-related muscle diseases    muscular dystrophy-dystroglycanopathy , type a, 7    autosomal recessive limb-girdle muscular dystrophy due to ispd deficiency    walker-warburg syndrome
    muscular dystrophy-dystroglycanopathy , type b, 4    muscular dystrophy-dystroglycanopathy

    2 diseases from the University of Copenhagen DISEASES database for ISPD:
    Peritonitis     Walker-Warburg syndrome

    Find genes that share disorders with ISPD           About GenesLikeMe

    Genetic Association Database (GAD): ISPD
    Human Genome Epidemiology (HuGE) Navigator: ISPD (4 documents)

    Export disorders for ISPD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISPD gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with ISPD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ISPD loss-of-function mutations disrupt dystroglycan O-mannosylation and cause Walker-Warburg syndrome. (PubMed id 22522420)1, 2 Willer T.... Campbell K.P. (Nat. Genet. 2012)
    2. Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of alpha-dystroglycan. (PubMed id 22522421)1, 2 Roscioli T.... van Bokhoven H. (Nat. Genet. 2012)
    3. Identification of mutations in TMEM5 and ISPD as a cause of severe cobblestone lissencephaly. (PubMed id 23217329)1, 2 Vuillaumier-Barrot S....Seta N. (Am. J. Hum. Genet. 2012)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The sequence of the human genome. (PubMed id 11181995)1, 3 Venter J.C.... Zhu X. (Science 2001)
    8. Impact of four loci on serum tamsulosin hydrochloride concentration. (PubMed id 23151678)1 Takata R....Nakamura Y. (J. Hum. Genet. 2013)
    9. ISPD gene mutations are a common cause of congenital and limb-girdle muscular dystrophies. (PubMed id 23288328)1 Cirak S....Muntoni F. (Brain 2013)
    10. Limb-girdle muscular dystrophy with I+-dystroglycan deficiency and mutations in the ISPD gene. (PubMed id 23390185)1 Tasca G....Ricci E. (Neurology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729920 HGNC: 37276 Ensembl:ENSG00000214960 euGenes: HUgn729920 ECgene: ISPD
    H-InvDB: ISPD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ISPD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISPD gene:
    Search GeneIP for patents involving ISPD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ISPD  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ISPD  
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     Block miRNA regulation of human, mouse, rat ISPD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ISPD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISPD Predesigned siRNA for gene silencing in human, mouse, rat ISPD
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     Custom PCR Arrays for ISPD Search Chromatin IP Primers for ISPD
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     Search Tocris compounds for ISPD
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     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for ISPD
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for ISPD
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     Search ThermoFisher Antibodies for ISPD
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ISPD
     Browse compounds at ApexBio
     Search Addgene for plasmids for ISPD
      Search eBioscience for proteins for ISPD
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      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ISPD
     antibodies-online antibodies for ISPD (10 products)
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     antibodies-online proteins for ISPD (3 products)
           
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