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Aliases for ISOC2 Gene

Aliases for ISOC2 Gene

  • Isochorismatase Domain Containing 2 2 3

External Ids for ISOC2 Gene

Previous GeneCards Identifiers for ISOC2 Gene

  • GC19M060657
  • GC19M055964
  • GC19M052278

Summaries for ISOC2 Gene

GeneCards Summary for ISOC2 Gene

ISOC2 (Isochorismatase Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ISOC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISOC2 Gene

Genomics for ISOC2 Gene

Regulatory Elements for ISOC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ISOC2 Gene

55,452,978 bp from pter
55,462,343 bp from pter
9,366 bases
Minus strand

Genomic View for ISOC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISOC2 Gene

Proteins for ISOC2 Gene

  • Protein details for ISOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Isochorismatase domain-containing protein 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6ZN91
    • Q9H5G0

    Protein attributes for ISOC2 Gene

    205 amino acids
    Molecular mass:
    22337 Da
    Quaternary structure:
    • Interacts with CDKN2A.

    Alternative splice isoforms for ISOC2 Gene


neXtProt entry for ISOC2 Gene

Proteomics data for ISOC2 Gene at MOPED

Post-translational modifications for ISOC2 Gene

  • Ubiquitination at Lys26
  • Modification sites at PhosphoSitePlus

Other Protein References for ISOC2 Gene

No data available for DME Specific Peptides for ISOC2 Gene

Domains for ISOC2 Gene

Protein Domains for ISOC2 Gene

Suggested Antigen Peptide Sequences for ISOC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the isochorismatase family.
  • Belongs to the isochorismatase family.
genes like me logo Genes that share domains with ISOC2: view

No data available for Gene Families for ISOC2 Gene

Function for ISOC2 Gene

Gene Ontology (GO) - Molecular Function for ISOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 17658461
genes like me logo Genes that share ontologies with ISOC2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ISOC2 Gene

Localization for ISOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISOC2 Gene

Mitochondrion. Cytoplasm. Nucleus. Note=Localizes to the nucleus in the presence of CDKN2A.

Subcellular locations from

Jensen Localization Image for ISOC2 Gene COMPARTMENTS Subcellular localization image for ISOC2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ISOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17658461
GO:0005737 cytoplasm IDA 17658461
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ISOC2: view

Pathways for ISOC2 Gene

SuperPathways for ISOC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0031648 protein destabilization IMP 17658461
genes like me logo Genes that share ontologies with ISOC2: view

No data available for Pathways by source for ISOC2 Gene

Transcripts for ISOC2 Gene

Unigene Clusters for ISOC2 Gene

Isochorismatase domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ISOC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISOC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -

Relevant External Links for ISOC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISOC2 Gene

mRNA expression in normal human tissues for ISOC2 Gene

mRNA differential expression in normal tissues according to GTEx for ISOC2 Gene

This gene is overexpressed in Liver (6.0).

Protein differential expression in normal tissues for ISOC2 Gene

This gene is overexpressed in Liver, secretome (8.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISOC2 Gene

SOURCE GeneReport for Unigene cluster for ISOC2 Gene Hs.467306

genes like me logo Genes that share expressions with ISOC2: view

Expression partners for ISOC2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ISOC2 Gene

Orthologs for ISOC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISOC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ISOC2 35
  • 83.99 (n)
  • 84.8 (a)
ISOC2 36
  • 85 (a)
(Canis familiaris)
Mammalia ISOC2 35
  • 87.75 (n)
  • 89.22 (a)
ISOC2 36
  • 88 (a)
(Mus musculus)
Mammalia Isoc2a 35
  • 83.58 (n)
  • 84.24 (a)
Isoc2a 16
Isoc2a 36
  • 83 (a)
Isoc2b 36
  • 73 (a)
(Pan troglodytes)
Mammalia ISOC2 35
  • 95.93 (n)
  • 92.89 (a)
ISOC2 36
  • 88 (a)
(Rattus norvegicus)
Mammalia LOC684270 35
  • 84.8 (n)
  • 85.29 (a)
(Ornithorhynchus anatinus)
Mammalia ISOC2 36
  • 40 (a)
(Anolis carolinensis)
Reptilia ISOC2 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia isoc2 35
  • 67.53 (n)
  • 67.53 (a)
(Danio rerio)
Actinopterygii Dr.18936 35
isoc2 35
  • 61.58 (n)
  • 61.58 (a)
isoc2 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9803 35
(Caenorhabditis elegans)
Secernentea F35G2.2 35
  • 53.68 (n)
  • 55.26 (a)
F35G2.2 36
  • 51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4832 35
Species with no ortholog for ISOC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ISOC2 Gene

Gene Tree for ISOC2 (if available)
Gene Tree for ISOC2 (if available)

Paralogs for ISOC2 Gene

Paralogs for ISOC2 Gene

(1) SIMAP similar genes for ISOC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISOC2: view

Variants for ISOC2 Gene

Sequence variations from dbSNP and Humsavar for ISOC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs751152 -- 55,462,050(+) CCCCA(C/T)TGCAC upstream-variant-2KB
rs753754 -- 55,462,779(-) GTGGC(A/G)CATAC upstream-variant-2KB
rs1052837 -- 55,453,040(-) GGGAA(A/G)AAGAG utr-variant-3-prime
rs1052841 -- 55,453,018(-) GGGAC(A/C)CGGAC utr-variant-3-prime
rs2005003 -- 55,462,850(-) ttcaa(A/G)accag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ISOC2 Gene

Variant ID Type Subtype PubMed ID
nsv912457 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv912473 CNV Loss 21882294
dgv4021n71 CNV Loss 21882294
nsv912478 CNV Loss 21882294
esv2718968 CNV Deletion 23290073
esv2718969 CNV Deletion 23290073
dgv4022n71 CNV Loss 21882294
dgv4023n71 CNV Loss 21882294

Relevant External Links for ISOC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISOC2 Gene

Disorders for ISOC2 Gene

No disorders were found for ISOC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ISOC2 Gene

Publications for ISOC2 Gene

  1. Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. (PMID: 17658461) Huang X. … Fu S. (Biochem. Biophys. Res. Commun. 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for ISOC2 Gene

Sources for ISOC2 Gene

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