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Aliases for ISOC2 Gene

Aliases for ISOC2 Gene

  • Isochorismatase Domain Containing 2 2 3 5

External Ids for ISOC2 Gene

Previous GeneCards Identifiers for ISOC2 Gene

  • GC19M060657
  • GC19M055964
  • GC19M052278

Summaries for ISOC2 Gene

GeneCards Summary for ISOC2 Gene

ISOC2 (Isochorismatase Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is ISOC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISOC2 Gene

Genomics for ISOC2 Gene

Regulatory Elements for ISOC2 Gene

Enhancers for ISOC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055421 1.1 Ensembl ENCODE 13 +40.8 40843 0.6 MAX MYC SHISA7 ISOC2 ZNF628 RPL28 TMEM238 MIR6805 BRSK1 TMEM190 TNNT1 HSPBP1
GH19F055417 0.8 Ensembl ENCODE 12.7 +44.0 43962 0.8 PKNOX1 WRNIP1 ARID4B GLI4 ZNF2 RAD21 RFX5 ZNF143 FOS MIXL1 SHISA7 ISOC2 ZNF628 MIR6805 RPL28 TMEM238 TMEM190 BRSK1 HSPBP1 PPP6R1
GH19F055516 1 Ensembl ENCODE 11.1 -54.8 -54824 1.3 HDGF ATF1 ARID4B SIN3A GLI4 BRCA1 CBX5 ZNF143 FOS KLF13 SBK2 SBK3 SSC5D NAT14 ZNF580 ZNF581 CCDC106 ZNF628 FIZ1 ZNF524
GH19F055519 1 FANTOM5 Ensembl ENCODE 11.1 -57.9 -57867 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055382 1.1 ENCODE 10.9 +75.5 75480 8.2 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF207 PAF1 ZNF263 SP3 RPL28 RFPL4AP1 RPL13P13 MIR6805 ZNF581 U2AF2 COX6B2 BRSK1 FAM71E2 SHISA7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ISOC2 on UCSC Golden Path with GeneCards custom track

Promoters for ISOC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001420141 843 1801 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for ISOC2 Gene

Chromosome:
19
Start:
55,452,978 bp from pter
End:
55,462,343 bp from pter
Size:
9,366 bases
Orientation:
Minus strand

Genomic View for ISOC2 Gene

Genes around ISOC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISOC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISOC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISOC2 Gene

Proteins for ISOC2 Gene

  • Protein details for ISOC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AB3-ISOC2_HUMAN
    Recommended name:
    Isochorismatase domain-containing protein 2
    Protein Accession:
    Q96AB3
    Secondary Accessions:
    • Q6ZN91
    • Q9H5G0

    Protein attributes for ISOC2 Gene

    Size:
    205 amino acids
    Molecular mass:
    22337 Da
    Quaternary structure:
    • Interacts with CDKN2A.

    Alternative splice isoforms for ISOC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ISOC2 Gene

Post-translational modifications for ISOC2 Gene

  • Ubiquitination at Lys 26
  • Modification sites at PhosphoSitePlus

Other Protein References for ISOC2 Gene

No data available for DME Specific Peptides for ISOC2 Gene

Domains & Families for ISOC2 Gene

Protein Domains for ISOC2 Gene

Suggested Antigen Peptide Sequences for ISOC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AB3

UniProtKB/Swiss-Prot:

ISOC2_HUMAN :
  • Belongs to the isochorismatase family.
Family:
  • Belongs to the isochorismatase family.
genes like me logo Genes that share domains with ISOC2: view

No data available for Gene Families for ISOC2 Gene

Function for ISOC2 Gene

Gene Ontology (GO) - Molecular Function for ISOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 17658461
genes like me logo Genes that share ontologies with ISOC2: view
genes like me logo Genes that share phenotypes with ISOC2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ISOC2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISOC2 Gene

Localization for ISOC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISOC2 Gene

Cytoplasm. Nucleus. Note=Localizes to the nucleus in the presence of CDKN2A.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISOC2 Gene COMPARTMENTS Subcellular localization image for ISOC2 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for ISOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17658461
GO:0005737 cytoplasm IDA 17658461
genes like me logo Genes that share ontologies with ISOC2: view

Pathways & Interactions for ISOC2 Gene

SuperPathways for ISOC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISOC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0031648 protein destabilization IMP 17658461
genes like me logo Genes that share ontologies with ISOC2: view

No data available for Pathways by source and SIGNOR curated interactions for ISOC2 Gene

Transcripts for ISOC2 Gene

Unigene Clusters for ISOC2 Gene

Isochorismatase domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISOC2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8:

Relevant External Links for ISOC2 Gene

GeneLoc Exon Structure for
ISOC2
ECgene alternative splicing isoforms for
ISOC2

Expression for ISOC2 Gene

mRNA expression in normal human tissues for ISOC2 Gene

mRNA differential expression in normal tissues according to GTEx for ISOC2 Gene

This gene is overexpressed in Liver (x6.0).

Protein differential expression in normal tissues from HIPED for ISOC2 Gene

This gene is overexpressed in Liver, secretome (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ISOC2 Gene



Protein tissue co-expression partners for ISOC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ISOC2 Gene:

ISOC2

SOURCE GeneReport for Unigene cluster for ISOC2 Gene:

Hs.467306
genes like me logo Genes that share expression patterns with ISOC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ISOC2 Gene

Orthologs for ISOC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISOC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISOC2 34 35
  • 95.93 (n)
dog
(Canis familiaris)
Mammalia ISOC2 34 35
  • 87.75 (n)
rat
(Rattus norvegicus)
Mammalia LOC684270 34
  • 84.8 (n)
cow
(Bos Taurus)
Mammalia ISOC2 34 35
  • 83.99 (n)
mouse
(Mus musculus)
Mammalia Isoc2a 34 16 35
  • 83.58 (n)
Isoc2b 35
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ISOC2 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ISOC2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia isoc2 34
  • 67.53 (n)
zebrafish
(Danio rerio)
Actinopterygii isoc2 34 35
  • 61.58 (n)
Dr.18936 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9803 34
worm
(Caenorhabditis elegans)
Secernentea F35G2.2 34 35
  • 53.68 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4832 34
Species where no ortholog for ISOC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ISOC2 Gene

ENSEMBL:
Gene Tree for ISOC2 (if available)
TreeFam:
Gene Tree for ISOC2 (if available)

Paralogs for ISOC2 Gene

Paralogs for ISOC2 Gene

(1) SIMAP similar genes for ISOC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISOC2: view

Variants for ISOC2 Gene

Sequence variations from dbSNP and Humsavar for ISOC2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10404500 -- 55,462,497(+) cccac(C/T)gcagg upstream-variant-2KB
rs10405756 -- 55,453,933(+) TAACC(A/T)CCTTA intron-variant
rs10417833 -- 55,455,454(+) GAGGA(A/T)GGGGC intron-variant
rs10419344 -- 55,456,082(+) tggat(C/G)cctgg intron-variant
rs10419391 -- 55,456,189(+) cctgg(A/G)tctga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ISOC2 Gene

Variant ID Type Subtype PubMed ID
esv2718968 CNV deletion 23290073
esv2718969 CNV deletion 23290073
nsv953624 CNV deletion 24416366

Variation tolerance for ISOC2 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 35.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISOC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ISOC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISOC2 Gene

Disorders for ISOC2 Gene

Relevant External Links for ISOC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISOC2

No disorders were found for ISOC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISOC2 Gene

Publications for ISOC2 Gene

  1. Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a. (PMID: 17658461) Huang X. … Fu S. (Biochem. Biophys. Res. Commun. 2007) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for ISOC2 Gene

Sources for ISOC2 Gene

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