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Aliases for ISOC1 Gene

Aliases for ISOC1 Gene

  • Isochorismatase Domain Containing 1 2 3
  • Isochorismatase Domain-Containing Protein 1 3
  • CGI-111 3

External Ids for ISOC1 Gene

Previous GeneCards Identifiers for ISOC1 Gene

  • GC05P128459
  • GC05P123621
  • GC05P128430

Summaries for ISOC1 Gene

GeneCards Summary for ISOC1 Gene

ISOC1 (Isochorismatase Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is ISOC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISOC1 Gene

Genomics for ISOC1 Gene

Regulatory Elements for ISOC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ISOC1 Gene

Start:
129,094,749 bp from pter
End:
129,114,028 bp from pter
Size:
19,280 bases
Orientation:
Plus strand

Genomic View for ISOC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISOC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISOC1 Gene

Proteins for ISOC1 Gene

  • Protein details for ISOC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CN7-ISOC1_HUMAN
    Recommended name:
    Isochorismatase domain-containing protein 1
    Protein Accession:
    Q96CN7
    Secondary Accessions:
    • Q7Z770

    Protein attributes for ISOC1 Gene

    Size:
    298 amino acids
    Molecular mass:
    32237 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH08367.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH14105.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ISOC1 Gene

Proteomics data for ISOC1 Gene at MOPED

Post-translational modifications for ISOC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISOC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISOC1 Gene

Domains for ISOC1 Gene

Protein Domains for ISOC1 Gene

Suggested Antigen Peptide Sequences for ISOC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CN7

UniProtKB/Swiss-Prot:

ISOC1_HUMAN :
  • Q96CN7
Family:
  • Belongs to the isochorismatase family.
genes like me logo Genes that share domains with ISOC1: view

No data available for Gene Families for ISOC1 Gene

Function for ISOC1 Gene

Gene Ontology (GO) - Molecular Function for ISOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ISOC1: view

Animal Model Products

miRNA for ISOC1 Gene

miRTarBase miRNAs that target ISOC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ISOC1 Gene

Localization for ISOC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISOC1 Gene COMPARTMENTS Subcellular localization image for ISOC1 gene
Compartment Confidence
peroxisome 3
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ISOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome ISS 14561759
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ISOC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ISOC1 Gene

Pathways for ISOC1 Gene

SuperPathways for ISOC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISOC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ISOC1: view

No data available for Pathways by source for ISOC1 Gene

Transcripts for ISOC1 Gene

mRNA/cDNA for ISOC1 Gene

(199) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ISOC1 Gene

Isochorismatase domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ISOC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISOC1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2: -

Relevant External Links for ISOC1 Gene

GeneLoc Exon Structure for
ISOC1
ECgene alternative splicing isoforms for
ISOC1

Expression for ISOC1 Gene

mRNA expression in normal human tissues for ISOC1 Gene

Protein differential expression in normal tissues for ISOC1 Gene

This gene is overexpressed in Uterus (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISOC1 Gene

SOURCE GeneReport for Unigene cluster for ISOC1 Gene Hs.483296

genes like me logo Genes that share expressions with ISOC1: view

Expression partners for ISOC1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ISOC1 Gene

Orthologs for ISOC1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISOC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ISOC1 35
  • 93.06 (n)
  • 97.32 (a)
ISOC1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ISOC1 35
  • 91.28 (n)
  • 95.96 (a)
ISOC1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Isoc1 35
  • 86.31 (n)
  • 93.94 (a)
Isoc1 16
Isoc1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ISOC1 35
  • 99.78 (n)
  • 100 (a)
ISOC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Isoc1 35
  • 84.96 (n)
  • 93.6 (a)
oppossum
(Monodelphis domestica)
Mammalia ISOC1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ISOC1 35
  • 83.27 (n)
  • 94.91 (a)
ISOC1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ISOC1 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia isoc1 35
  • 77.42 (n)
  • 94.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29962 35
zebrafish
(Danio rerio)
Actinopterygii isoc1 35
  • 71.74 (n)
  • 84.42 (a)
isoc1 36
  • 65 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002320 35
  • 50.69 (n)
  • 45.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3663 35
  • 53 (n)
  • 44.94 (a)
CG11333 36
  • 40 (a)
OneToMany
CG3663 36
  • 39 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00166 35
  • 41.77 (n)
  • 36.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for ISOC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISOC1 Gene

ENSEMBL:
Gene Tree for ISOC1 (if available)
TreeFam:
Gene Tree for ISOC1 (if available)

Paralogs for ISOC1 Gene

Paralogs for ISOC1 Gene

Selected SIMAP similar genes for ISOC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ISOC1: view

Variants for ISOC1 Gene

Sequence variations from dbSNP and Humsavar for ISOC1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs6871 -- 129,113,951(-) TCTAA(C/T)AAGTA utr-variant-3-prime
rs14822 -- 129,113,909(-) AATGA(C/T)CACAA utr-variant-3-prime
rs766328 -- 129,104,815(+) TTCAG(A/G)TACTT intron-variant
rs976607 -- 129,105,534(-) CAGTG(C/T)CATGC intron-variant
rs1127827 -- 129,095,064(+) TGCCG(C/T)TGCAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ISOC1 Gene

Variant ID Type Subtype PubMed ID
nsv830485 CNV Gain 17160897
nsv882842 CNV Loss 21882294
nsv882847 CNV Loss 21882294
nsv882848 CNV Loss 21882294
nsv882849 CNV Loss 21882294

Relevant External Links for ISOC1 Gene

HapMap Linkage Disequilibrium report
ISOC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISOC1 Gene

Disorders for ISOC1 Gene

(1) University of Copenhagen DISEASES for ISOC1 Gene

Relevant External Links for ISOC1

Genetic Association Database (GAD)
ISOC1
genes like me logo Genes that share disorders with ISOC1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ISOC1 Gene

Publications for ISOC1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Microarray study of gene expression in uterine leiomyoma. (PMID: 18566572) Litovkin K.V. … Zaporozhan V.N. (Exp. Oncol. 2008) 2 3
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Proteomic analysis of rat liver peroxisome: presence of peroxisome- specific isozyme of Lon protease. (PMID: 14561759) Kikuchi M. … Taniguchi H. (J. Biol. Chem. 2004) 3

Products for ISOC1 Gene

Sources for ISOC1 Gene

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