ISOC1 Gene
protein-coding GIFtS: 45
GCID: GC05P128430
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|
isochorismatase domain containing 1
| |
Aliases
for ISOC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Isochorismatase Domain Containing 11 2 | | CGI-1111 | | Isochorismatase Domain-Containing Protein 12 |
Export aliases for ISOC1 gene to outside databasesPrevious GC identifers: GC05P128459 GC05P123621 |
Summaries
for ISOC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ISOC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ISOC1 gene promoter:
Tal-1 AML1a Brachyury POU3F2 FOXL1 E47 PPAR-gamma1 POU2F1 Chx10 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ISOC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISOC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q22.1-q33.3 Ensembl cytogenetic band: 5q23.3 HGNC cytogenetic band: 5q22.1-q33.3ISOC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P128430: view genomic region
(about GC identifiers)
Start:
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128,430,386 bp from pter |
End:
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128,449,721 bp from pter |
Size:
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19,336 bases |
Orientation:
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plus strand |
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Proteins
for ISOC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ISOC1_HUMAN, Q96CN7 (See
protein sequence)Recommended Name: Isochorismatase domain-containing protein 1 Size: 298 amino acids; 32237 Da
Sequence caution: Sequence=AAH08367.1; Type=Erroneous initiation; Sequence=AAH14105.2; Type=Erroneous initiation;
Secondary accessions: Q7Z770Explore the universe of human proteins at neXtProt for ISOC1: NX_Q96CN7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CN7
ISOC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057132.2
ENSEMBL proteins: ENSP00000423512 ENSP00000421273 ENSP00000173527 ENSP00000426921
Human Recombinant Protein Products for ISOC1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ISOC1 for ontologies About GeneDecksing
ISOC1 Antibody Products:
Assay Products for ISOC1: |
Protein
Domains /
Families
for ISOC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ISOC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96CN7ProtoNet protein and cluster: Q96CN7 1 Blocks protein family: IPB000868 Isochorismatase hydrolase family
UniProtKB/Swiss-Prot: ISOC1_HUMAN, Q96CN7Similarity: Belongs to the isochorismatase family |
Function
for ISOC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003824 | catalytic activity |
IEA | -- |
ISOC1 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISOC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISOC1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ISOC1 (NM_016048) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ISOC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISOC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISOC1 |
|
Pathways & Interactions
for ISOC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ISOC1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for ISOC1 (Q96CN73 ENSP000001735274) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
ISOC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ISOC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ISOC1
Search CenterWatch for drugs/clinical trials and news about ISOC1
|
Transcripts
for ISOC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ISOC1 gene: NM_016048.2 Unigene Cluster for ISOC1: Isochorismatase domain containing 1 Hs.483296 [show with all ESTs]Unigene Representative Sequence: BC0083674 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506986 ENST00000514194 ENST00000173527(uc003kva.3) ENST00000513879
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISOC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISOC1 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ISOC1 (NM_016048) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ISOC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISOC1 |
Additional cDNA sequence: AK025787.1 BC008367.1 BC014105.2 7 DOTS entries: DT.216113 DT.120835017 DT.120835027 DT.91753017 DT.95103648 DT.100696922 DT.100781396 24/199 AceView cDNA sequences (see all 199): CR623281 BG493211 AA370947 AA953701 CB119742 AI274397 BX115260 AI261948 BP371761 AI433828 AI346783 AW965086 AI279090 AA918859 BQ638646 AA206816 BG613927 AI346747 AI023604 BC014105 AI571478 AI290685 BF313710 BF590261
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ISOC1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for ISOC1
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Expression
for ISOC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ISOC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTGTTCTA
About this image
See ISOC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ISOC1
SOURCE GeneReport for Unigene cluster: Hs.483296
SABiosciences Custom PCR Arrays for ISOC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISOC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ISOC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISOC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISOC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISOC1 |
Orthologs
for ISOC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ISOC1 gene from 7/25 species (see all 25) About this table
ENSEMBL Gene Tree for ISOC1 (if available)
TreeFam Gene Tree for ISOC1 (if available) |
Paralogs
for ISOC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ISOC1 gene
- ISOC22
1 SIMAP similar gene for ISOC1 using alignment to 4 protein entries: ISOC1_HUMAN (see all proteins):ISOC2
ISOC1 for paralogs About GeneDecksing
|
Genomic Variants
for ISOC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ISOC1 (128430386 - 128449721 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ISOC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISOC1 |
|
Disorders
/ Diseases
for ISOC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ISOC1 for disorders About GeneDecksing
2  diseases for ISOC1: About MalaCardsuterine fibroid leiomyoma
1 disease from the University of Copenhagen DISEASES database for ISOC1:Uterine fibroid Export disorders for ISOC1 gene to outside databases
|
Publications
for ISOC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ISOC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ISOC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Microarray study of gene expression in uterine leiomyoma. (PubMed id 18566572)1, 3 Litovkin K.V....Zaporozhan V.N. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 3 Lai C.H....Lin W. (2000)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Proteomic analysis of rat liver peroxisome: presence of peroxisome- specific isozyme of Lon protease. (PubMed id 14561759)1 Kikuchi M....Taniguchi H. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ISOC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ISOC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ISOC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ISOC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ISOC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ISOC1 gene:
Search GeneIP for patents involving ISOC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ISOC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ISOC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISOC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISOC1 | | | OriGene Protein Over-expression Lysate for ISOC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ISOC1 | | OriGene 3'-UTR Clone for ISOC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISOC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISOC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ISOC1 | | OriGene Custom Protein Services for ISOC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ISOC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISOC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISOC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISOC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISOC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISOC1 |
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 |  |  |  | |
| | | | Search Tocris compounds for ISOC1 |
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 | | | ISOC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISOC1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ISOC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISOC1 |
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