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ISM2 Gene

protein-coding   GIFtS: 49
GCID: GC14M077940

Isthmin 2

(Previous names: thrombospondin, type I domain-containing 3, thrombospondin,...)
(Previous symbol: THSD3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Isthmin 21 2     Thrombospondin And AMOP Domain-Containing Isthmin-Like Protein 12 3
THSD31 2 3 5     Thrombospondin Type-1 Domain-Containing Protein 32 3
TAIL12 3 5     Isthmin 2 Homolog (Zebrafish)1
Thrombospondin, Type I Domain-Containing 31 2     Isthmin 2 Homolog2
Thrombospondin, Type I, Domain Containing 31 2     isthmin-22
Thrombospondin And AMOP Containing Isthmin-Like 11 2     

External Ids:    HGNC: 231761   Entrez Gene: 1455012   Ensembl: ENSG000001005937   OMIM: 6126845   UniProtKB: Q6H9L73   

Export aliases for ISM2 gene to outside databases

Previous GC identifers: GC14M077011 GC14M058106


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ISM2 Gene:
The protein encoded by this gene contains a type 1 thrombospondin domain, which is present in thrombospondin, a
number of proteins involved in the complement pathway, as well as in extracellular matrix proteins. Two
alternatively spliced transcript variants encoding distinct isoforms have been observed. (provided by RefSeq, Mar
2009)

GeneCards Summary for ISM2 Gene:
ISM2 (isthmin 2) is a protein-coding gene. An important paralog of this gene is ISM1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISM2 gene promoter:
         TBP   Pax-5   AML1a   Nkx2-2   Nkx2-5   RORalpha2   Arnt   POU2F1a   TFIID   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISM2 promoter sequence
   Search Chromatin IP Primers for ISM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

ISM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISM2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M077940:  view genomic region     (about GC identifiers)

Start:
77,940,737 bp from pter      End:
77,965,210 bp from pter
Size:
24,474 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ISM2_HUMAN, Q6H9L7 (See protein sequence)
Recommended Name: Isthmin-2 precursor  
Size: 571 amino acids; 63906 Da
Sequence caution: Sequence=AAD09622.1; Type=Erroneous gene model prediction; Sequence=CAD62605.1; Type=Erroneous
initiation; Sequence=CAD66577.1; Type=Erroneous initiation; Sequence=EAW81296.1; Type=Erroneous gene model
prediction;
Secondary accessions: A8K6D5 O95432 Q495U5 Q68CN3 Q86TQ7 Q86TW3 Q86TW4 Q8N501 Q8NBL0
Alternative splicing: 5 isoforms:  Q6H9L7-1   Q6H9L7-2   Q6H9L7-3   Q6H9L7-4   Q6H9L7-5   

Explore the universe of human proteins at neXtProt for ISM2: NX_Q6H9L7

Explore proteomics data for ISM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn117, Thr200, Ser202, Thr203, Thr211, Asn300, Asn392
  • Modification sites at PhosphoSitePlus

  • See ISM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_872315.2  NP_954993.1  

    ENSEMBL proteins: 
     ENSP00000216481   ENSP00000341490   ENSP00000420452   ENSP00000450791   ENSP00000417679  
     ENSP00000419434   ENSP00000416773   ENSP00000395387   ENSP00000377289  

    ISM2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ISM2
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    Novus Biologicals ISM2 Protein
    Novus Biologicals ISM2 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISM2

     
    Search eBioscience for Proteins for ISM2 

    ISM2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for ISM2
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    Search LSBio for Antibodies for ISM2

    ISM2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ISM2
    Cloud-Clone Corp. CLIAs for ISM2
    Search eBioscience for ELISAs for ISM2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000884 Thrombospondin_1_rpt
     IPR005533 AMOP

    Graphical View of Domain Structure for InterPro Entry Q6H9L7

    ProtoNet protein and cluster: Q6H9L7

    UniProtKB/Swiss-Prot: ISM2_HUMAN, Q6H9L7
    Similarity: Belongs to the isthmin family
    Similarity: Contains 1 AMOP domain
    Similarity: Contains 1 TSP type-1 domain


    Find genes that share domains with ISM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for ISM2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISM2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ISM2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISM2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ISM2:
    hsa-mir-92a-3p (MIRT049167), hsa-mir-484 (MIRT042370)

    Block miRNA regulation of human, mouse, rat ISM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISM2 (see all 29):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-137 hsa-miR-106a hsa-miR-302e hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidISM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ISM2
    Predesigned siRNA for gene silencing in human, mouse, rat ISM2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ISM2

    Clone
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    OriGene clones in human, mouse for ISM2 (see all 13)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISM2 (NM_199296)
    Sino Biological Human cDNA Clone for ISM2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ISM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ISM2_HUMAN, Q6H9L7: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    extracellular3
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus ----

    Find genes that share ontologies with ISM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISM2
    Interactions:

        Search GeneGlobe Interaction Network for ISM2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ISM2 gene (3 alternative transcripts): 
    NM_182509.3  NM_199296.2  NM_199265.2  

    Unigene Cluster for ISM2:

    Isthmin 2 homolog (zebrafish)
    Hs.29742  [show with all ESTs]
    Unigene Representative Sequence: CR749863
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216481 ENST00000342219(uc001xtz.3 uc001xua.3) ENST00000493585
    ENST00000487738 ENST00000554801 ENST00000471734 ENST00000472744 ENST00000480979
    ENST00000412904 ENST00000429906 ENST00000393684(uc001xty.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ISM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISM2 (see all 29):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-137 hsa-miR-106a hsa-miR-302e hsa-miR-1285
    SwitchGear 3'UTR luciferase reporter plasmidISM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ISM2
    Predesigned siRNA for gene silencing in human, mouse, rat ISM2
    Clone
    Products:
         
    OriGene clones in human, mouse for ISM2 (see all 13)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISM2 (NM_199296)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISM2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ISM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat ISM2
      QuantiTect SYBR Green Assays in human, mouse, rat ISM2
      QuantiFast Probe-based Assays in human, mouse, rat ISM2

    Additional mRNA sequence: 

    AJ583024.1 AK075445.1 AK291600.1 AK300214.1 BC033140.1 BC101019.1 BC101020.1 BC101021.2 
    BC101022.2 BX248277.1 BX248280.1 BX248770.1 BX248771.1 CR749863.1 

    14 DOTS entries:

    DT.100018081  DT.100883447  DT.101985331  DT.100719427  DT.100883489  DT.100808926  DT.100883451  DT.100883483 
    DT.100775526  DT.100841397  DT.100841398  DT.100883449  DT.100883455  DT.100883487 

    Selected AceView cDNA sequences (see all 197):

    CR593679 CR591527 AJ583024 CR597238 CR609209 BX248770 NM_199265 BX248771 
    CR604661 CR615195 BX248280 AA779261 BX248277 CR606304 CR606820 BX439514 
    CR618365 CR621416 AI188552 BX387067 NM_182509 NM_199296 CR601544 BX360443 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ISM2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                              -     -                                 
    SP2:                                -     -                       -     -                                 
    SP3:                                -     -                       -     -     -                           
    SP4:                                                                                                      
    SP5:                                -     -                                                               


    ECgene alternative splicing isoforms for ISM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ISM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTTCCCT
    ISM2 Expression
    About this image


    ISM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Placenta (Extraembryonic Tissues)
    ISM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.29742

    UniProtKB/Swiss-Prot: ISM2_HUMAN, Q6H9L7
    Tissue specificity: Expressed at high levels in the placenta and at moderate levels in the pancreas, kidney,
    heart, liver, lung, brain and skeletal muscle

        Custom PCR Arrays for ISM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ISM2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ism25 isthmin 2 homolog (zebrafish)   --   12 (41.49 cM) 87278638 
    chicken
    (Gallus gallus)
    Aves ISM26
    isthmin 2
    48(a)
    1 ↔ 1
    5(38524087-38527515)
    lizard
    (Anolis carolinensis)
    Reptilia ISM26
    isthmin 2
    50(a)
    1 ↔ 1
    1(20649279-20660223)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.152012 Xenopus laevis transcribed sequences 73.71(n)    CB943048.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ism2b1 isthmin 2b 60.56(n)
    51.55(a)
      553163  NM_001020509.1  NP_001018345.1 


    ENSEMBL Gene Tree for ISM2 (if available)
    TreeFam Gene Tree for ISM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ISM2 gene
    ISM12  
    1 SIMAP similar gene for ISM2 using alignment to 5 protein entries:     ISM2_HUMAN (see all proteins):
    ISM1

    Find genes that share paralogs with ISM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ISM2 (see all 679)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831229891,2
    --77940307(+) TGTCCG/TTCCCC 2 -- ds50010--------
    rs566535011,2
    C,F--77940314(+) CCCCAC/TGTCAG 2 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1876637741,2
    --77940341(+) TCTAGA/TTGGGG 2 -- ds50010--------
    rs1466381011,2
    C--77940366(+) GAGCAC/TGGATC 2 -- ds50010--------
    rs49035871,2
    C,F,H--77940515(+) CTCCTC/TGTCCA 2 -- ds50015Minor allele frequency- T:0.06NS EA WA 536
    rs791854501,2
    C,F--77940727(+) CTTCAT/CCAGGC 2 -- ds50011Minor allele frequency- C:0.13WA 118
    rs10036481,2
    C,F,H--77940827(+) TTGGTG/AGCTCT 2 -- ut31 ese311Minor allele frequency- A:0.03MN NS EA NA WA 1390
    rs81351,2
    C,F,H--77940860(-) GAAATG/ATTGAA 2 -- ut3129Minor allele frequency- A:0.11NA EA MN NS WA CSA 2416
    rs1913831111,2
    --77940935(+) TGCCGA/GGAGAG 2 -- ut310--------
    rs1821451291,2
    --77940966(+) CAACTC/GTGAGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ISM2 (77940737 - 77965210 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ISM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832835CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISM2
    DNA2.0 Custom Variant and Variant Library Synthesis for ISM2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612684    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ISM2:
    Arrhythmogenic right ventricular dysplasia

    Find genes that share disorders with ISM2           About GenesLikeMe


    Export disorders for ISM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISM2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ISM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region. (PubMed id 15194193)1, 2, 3, 9 Rossi V.... Danieli G.A. (Gene 2004)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. The modular architecture of a new family of growth regulators related to connective tissue growth factor. (PubMed id 7687569)1 Bork P. (FEBS Lett. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 145501 HGNC: 23176 AceView: THSD3 Ensembl:ENSG00000100593 euGenes: HUgn145501
    ECgene: ISM2 H-InvDB: ISM2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ISM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISM2 gene:
    Search GeneIP for patents involving ISM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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