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Aliases for ISLR2 Gene

Aliases for ISLR2 Gene

  • Immunoglobulin Superfamily Containing Leucine Rich Repeat 2 2 3 5
  • Leucine-Rich Repeat Domain And Immunoglobulin Domain-Containing Axon Extension Protein 3 4
  • LINX 3 4
  • Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein 2 3
  • KIAA1465 4

External Ids for ISLR2 Gene

Previous GeneCards Identifiers for ISLR2 Gene

  • GC15P072209
  • GC15P074421
  • GC15P051215
  • GC15P074392

Summaries for ISLR2 Gene

GeneCards Summary for ISLR2 Gene

ISLR2 (Immunoglobulin Superfamily Containing Leucine Rich Repeat 2) is a Protein Coding gene. An important paralog of this gene is ISLR.

UniProtKB/Swiss-Prot for ISLR2 Gene

  • Required for axon extension during neural development.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISLR2 Gene

Genomics for ISLR2 Gene

Regulatory Elements for ISLR2 Gene

Enhancers for ISLR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G074199 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +101.7 101732 5.3 SIN3A FEZF1 ZNF2 GLIS2 ZNF548 FOS DEK ZNF263 SP3 JUNB ISLR2 EDC3 ISLR CCDC33 ENSG00000261543
GH15G074207 1.5 Ensembl ENCODE dbSUPER 10.3 +109.3 109305 3.5 PKNOX1 ATF1 CREB3L1 FEZF1 ETS1 GLIS2 FOS ZNF263 YY2 REST ISLR2 LOC283731 STRA6 CCDC33
GH15G074176 1.4 Ensembl ENCODE dbSUPER 10.8 +78.4 78432 4.8 BRCA1 ZNF121 GLIS2 GATA2 ZNF143 FOS REST SMARCB1 MAFF SMARCA4 ISLR ENSG00000261543 ISLR2 EDC3
GH15G074213 1.4 Ensembl ENCODE dbSUPER 9.1 +114.5 114495 2.6 CBX3 FOXA2 ZSCAN9 ZNF121 ZNF416 FOS EGR2 ZNF263 SMARCA5 CEBPB EDC3 ISLR ISLR2 CYP1A1 LOC283731 STRA6 LOC105370893
GH15G074168 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +71.4 71448 7.3 CREB3L1 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZNF610 ISLR STRA6 ENSG00000261543 CCDC33 EDC3 ISLR2 SCAMP5 UBL7 CD276 PML
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ISLR2 on UCSC Golden Path with GeneCards custom track

Promoters for ISLR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the ISLR2 gene promoter:

Genomic Location for ISLR2 Gene

74,100,311 bp from pter
74,141,841 bp from pter
41,531 bases
Plus strand

Genomic View for ISLR2 Gene

Genes around ISLR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISLR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISLR2 Gene

Proteins for ISLR2 Gene

  • Protein details for ISLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily containing leucine-rich repeat protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K352
    • Q9P263

    Protein attributes for ISLR2 Gene

    745 amino acids
    Molecular mass:
    78990 Da
    Quaternary structure:
    • Homomultimer. Interacts with NTRK1/TrkA (By similarity).
    • Sequence=BAA95989.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ISLR2 Gene

Post-translational modifications for ISLR2 Gene

  • Glycosylation at isoforms=52, posLast=121121, posLast=337337, posLast=364364, isoforms=474, and isoforms=563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ISLR2 Gene

Domains & Families for ISLR2 Gene

Gene Families for ISLR2 Gene

Suggested Antigen Peptide Sequences for ISLR2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ISLR2: view

No data available for UniProtKB/Swiss-Prot for ISLR2 Gene

Function for ISLR2 Gene

Molecular function for ISLR2 Gene

UniProtKB/Swiss-Prot Function:
Required for axon extension during neural development.
genes like me logo Genes that share phenotypes with ISLR2: view

Animal Models for ISLR2 Gene

MGI Knock Outs for ISLR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ISLR2

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ISLR2 Gene

Localization for ISLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISLR2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISLR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IBA,ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ISLR2: view

Pathways & Interactions for ISLR2 Gene

SuperPathways for ISLR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0045773 positive regulation of axon extension ISS,IBA --
genes like me logo Genes that share ontologies with ISLR2: view

No data available for Pathways by source and SIGNOR curated interactions for ISLR2 Gene

Drugs & Compounds for ISLR2 Gene

No Compound Related Data Available

Transcripts for ISLR2 Gene

Unigene Clusters for ISLR2 Gene

Immunoglobulin superfamily containing leucine-rich repeat 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISLR2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for ISLR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISLR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISLR2 Gene

mRNA differential expression in normal tissues according to GTEx for ISLR2 Gene

This gene is overexpressed in Testis (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Cortex (x5.1), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Putamen (basal ganglia) (x4.7), Brain - Caudate (basal ganglia) (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for ISLR2 Gene

This gene is overexpressed in Lavage (35.8), Fetal Brain (19.5), and Prostate (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ISLR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ISLR2 Gene:


SOURCE GeneReport for Unigene cluster for ISLR2 Gene:


Evidence on tissue expression from TISSUES for ISLR2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with ISLR2: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISLR2 Gene

Orthologs for ISLR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISLR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ISLR2 34 35
  • 98.75 (n)
(Canis familiaris)
Mammalia ISLR2 34 35
  • 86.88 (n)
(Bos Taurus)
Mammalia ISLR2 34 35
  • 86.58 (n)
(Mus musculus)
Mammalia Islr2 34 16 35
  • 84.54 (n)
(Rattus norvegicus)
Mammalia LOC100910729 34
  • 84.09 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
(Gallus gallus)
Aves ISLR2 34 35
  • 63.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia islr2 34
  • 54.11 (n)
(Danio rerio)
Actinopterygii islr2 34 35
  • 54.34 (n)
fruit fly
(Drosophila melanogaster)
Insecta kek4 35
  • 17 (a)
kek2 35
  • 14 (a)
kek3 35
  • 14 (a)
kek5 35
  • 14 (a)
kek1 35
  • 13 (a)
kek6 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
CSA.1672 35
  • 20 (a)
-- 35
  • 19 (a)
Species where no ortholog for ISLR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISLR2 Gene

Gene Tree for ISLR2 (if available)
Gene Tree for ISLR2 (if available)

Paralogs for ISLR2 Gene

Paralogs for ISLR2 Gene

(9) SIMAP similar genes for ISLR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ISLR2: view

Variants for ISLR2 Gene

Sequence variations from dbSNP and Humsavar for ISLR2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000021785 -- 74,140,679(+) CTAAC(A/G)AATAC intron-variant
rs1000027460 -- 74,135,936(+) AGTTG(C/G)AGTCC intron-variant, utr-variant-3-prime
rs1000028981 -- 74,136,896(+) GCCTC(C/T)CGTTG intron-variant, downstream-variant-500B
rs1000219885 -- 74,140,916(+) AGAGA(A/T)TAAAT intron-variant
rs1000394964 -- 74,128,440(+) CAGGA(A/G)CCCCG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ISLR2 Gene

Variant ID Type Subtype PubMed ID
esv2760040 CNV gain+loss 17122850
nsv1047564 CNV gain 25217958
nsv1050884 CNV gain 25217958
nsv1121512 CNV deletion 24896259
nsv428308 CNV gain+loss 18775914
nsv469619 CNV loss 16826518
nsv827385 CNV gain 20364138
nsv833053 CNV loss 17160897
nsv951993 CNV deletion 24416366

Variation tolerance for ISLR2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISLR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISLR2 Gene

Disorders for ISLR2 Gene

Relevant External Links for ISLR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ISLR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISLR2 Gene

Publications for ISLR2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ISLR2 Gene

Sources for ISLR2 Gene

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