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Aliases for ISLR2 Gene

Aliases for ISLR2 Gene

  • Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2 2 3
  • Leucine-Rich Repeat Domain And Immunoglobulin Domain-Containing Axon Extension Protein 3 4
  • LINX 3 4
  • KIAA1465 4

External Ids for ISLR2 Gene

Previous GeneCards Identifiers for ISLR2 Gene

  • GC15P072209
  • GC15P074421
  • GC15P051215
  • GC15P074392

Summaries for ISLR2 Gene

GeneCards Summary for ISLR2 Gene

ISLR2 (Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2) is a Protein Coding gene. An important paralog of this gene is SLITRK3.

UniProtKB/Swiss-Prot for ISLR2 Gene

  • Required for axon extension during neural development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISLR2 Gene

Genomics for ISLR2 Gene

Regulatory Elements for ISLR2 Gene

Transcription factor binding sites by QIAGEN in the ISLR2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ISLR2 Gene

74,100,311 bp from pter
74,141,841 bp from pter
41,531 bases
Plus strand

Genomic View for ISLR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISLR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISLR2 Gene

Proteins for ISLR2 Gene

  • Protein details for ISLR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily containing leucine-rich repeat protein 2
    Protein Accession:
    Secondary Accessions:
    • A8K352
    • Q9P263

    Protein attributes for ISLR2 Gene

    745 amino acids
    Molecular mass:
    78990 Da
    Quaternary structure:
    • Homomultimer. Interacts with NTRK1/TrkA (By similarity).
    • Sequence=BAA95989.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ISLR2 Gene

Proteomics data for ISLR2 Gene at MOPED

Post-translational modifications for ISLR2 Gene

  • Glycosylation at Asn 52, Asn 121, Asn 337, Asn 364, Asn 474, and Asn 563
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ISLR2 Gene

Domains & Families for ISLR2 Gene

Gene Families for ISLR2 Gene

Suggested Antigen Peptide Sequences for ISLR2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ISLR2: view

Function for ISLR2 Gene

Molecular function for ISLR2 Gene

UniProtKB/Swiss-Prot Function:
Required for axon extension during neural development.

Gene Ontology (GO) - Molecular Function for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ISLR2: view
genes like me logo Genes that share phenotypes with ISLR2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ISLR2 Gene

Localization for ISLR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISLR2 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ISLR2 Gene COMPARTMENTS Subcellular localization image for ISLR2 gene
Compartment Confidence
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ISLR2: view

Pathways & Interactions for ISLR2 Gene

SuperPathways for ISLR2 Gene

No Data Available

Interacting Proteins for ISLR2 Gene

Gene Ontology (GO) - Biological Process for ISLR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045773 positive regulation of axon extension ISS --
genes like me logo Genes that share ontologies with ISLR2: view

No data available for Pathways by source and SIGNOR curated interactions for ISLR2 Gene

Drugs & Compounds for ISLR2 Gene

No Compound Related Data Available

Transcripts for ISLR2 Gene

Unigene Clusters for ISLR2 Gene

Immunoglobulin superfamily containing leucine-rich repeat 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISLR2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: -

Relevant External Links for ISLR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISLR2 Gene

mRNA expression in normal human tissues for ISLR2 Gene

mRNA differential expression in normal tissues according to GTEx for ISLR2 Gene

This gene is overexpressed in Testis (x6.2), Brain - Nucleus accumbens (basal ganglia) (x5.2), Brain - Cortex (x5.1), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Putamen (basal ganglia) (x4.7), Brain - Caudate (basal ganglia) (x4.2), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for ISLR2 Gene

This gene is overexpressed in Lavage (35.8), Fetal Brain (19.5), and Prostate (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ISLR2 Gene

SOURCE GeneReport for Unigene cluster for ISLR2 Gene Hs.254775

genes like me logo Genes that share expression patterns with ISLR2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ISLR2 Gene

Orthologs for ISLR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISLR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ISLR2 35
  • 86.58 (n)
  • 90.34 (a)
ISLR2 36
  • 90 (a)
(Canis familiaris)
Mammalia ISLR2 35
  • 86.88 (n)
  • 90.03 (a)
ISLR2 36
  • 88 (a)
(Mus musculus)
Mammalia Islr2 35
  • 84.54 (n)
  • 89.38 (a)
Islr2 16
Islr2 36
  • 84 (a)
(Pan troglodytes)
Mammalia ISLR2 35
  • 98.75 (n)
  • 98.41 (a)
ISLR2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100910729 35
  • 84.09 (n)
  • 89.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Gallus gallus)
Aves ISLR2 35
  • 63.44 (n)
  • 58.63 (a)
ISLR2 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia islr2 35
  • 54.11 (n)
  • 51.55 (a)
(Danio rerio)
Actinopterygii islr2 35
  • 54.34 (n)
  • 51.17 (a)
islr2 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta kek1 36
  • 13 (a)
kek2 36
  • 14 (a)
kek3 36
  • 14 (a)
kek4 36
  • 17 (a)
kek5 36
  • 14 (a)
kek6 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
-- 36
  • 26 (a)
CSA.1672 36
  • 20 (a)
Species with no ortholog for ISLR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISLR2 Gene

Gene Tree for ISLR2 (if available)
Gene Tree for ISLR2 (if available)

Paralogs for ISLR2 Gene

(9) SIMAP similar genes for ISLR2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ISLR2: view

Variants for ISLR2 Gene

Sequence variations from dbSNP and Humsavar for ISLR2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3743207 -- 74,133,069(+) CTCGA(C/T)CTGAG synonymous-codon, reference, nc-transcript-variant
rs3889598 - 74,133,164(+) GGGCT(C/G/T)TCTGC reference, missense, nc-transcript-variant
rs3910071 -- 74,131,810(-) TGCTC(C/T)GCCAA intron-variant
rs5813743 -- 74,133,879(+) GCAAC(-/C)GGGCC frameshift-variant, reference, nc-transcript-variant
rs5813744 -- 74,141,957(+) TAGCA(-/T)TTTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ISLR2 Gene

Variant ID Type Subtype PubMed ID
dgv756e1 CNV Complex 17122850
nsv428308 CNV Gain+Loss 18775914
nsv469619 CNV Loss 16826518
nsv833053 CNV Loss 17160897
nsv827385 CNV Gain 20364138

Variation tolerance for ISLR2 Gene

Residual Variation Intolerance Score: 5.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.59; 56.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISLR2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISLR2 Gene

Disorders for ISLR2 Gene

Relevant External Links for ISLR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ISLR2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISLR2 Gene

Publications for ISLR2 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for ISLR2 Gene

Sources for ISLR2 Gene

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