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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ISLR2 Gene

protein-coding GIFtS: 48
GCID: GC15P074421

immunoglobulin superfamily containing leucine-rich repeat...

Explore 1 disease affiliated with
ISLR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2¹ ²
KIAA1465¹ ³
Leucine-Rich Repeat Domain And Immunoglobulin Domain-Containing Axon Extension Protein² ³
LINX² ³
Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein 2²

External Ids:	HGNC: 29286¹	Entrez Gene: 57611²	Ensembl: ENSG00000167178⁷	OMIM: 614179⁵	UniProtKB: Q6UXK2³

Export aliases for ISLR2 gene to outside databases

Previous GC identifers: GC15P072209 GC15P051215

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ISLR2_HUMAN, Q6UXK2

Function: Required for axon extension during neural development (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ISLR2 gene promoter:
FOXI1 HFH-3 AP-4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ISLR2 promoter sequence

Search SABiosciences Chromatin IP Primers for ISLR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISLR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.1 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q24.1

ISLR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISLR2 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P074421: view genomic region (about GC identifiers)

Start:	74,392,652 bp from pter	End:	74,430,881 bp from pter
Size:	38,230 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ISLR2_HUMAN, Q6UXK2 (See protein sequence)

Recommended Name: Immunoglobulin superfamily containing leucine-rich repeat protein 2 precursor

Size: 745 amino acids; 78990 Da

Subunit: Homomultimer. Interacts with NTRK1/TrkA (By similarity)

Subcellular location: Cell membrane; Single-pass membrane protein (By similarity)

Sequence caution: Sequence=BAA95989.2; Type=Erroneous initiation;

Secondary accessions: A8K352 Q9P263

Explore the universe of human proteins at neXtProt for ISLR2: NX_Q6UXK2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UXK2

ISLR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001123608.1 NP_001123609.1 NP_001123610.1 NP_065902.1

ENSEMBL proteins:

ENSP00000454287 ENSP00000355402 ENSP00000455531 ENSP00000454859 ENSP00000455076

ENSP00000411834 ENSP00000454259 ENSP00000458080 ENSP00000403244 ENSP00000411443

ENSP00000408872

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	Uscn Proteins for ISLR2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0009986	cell surface	ISS	--
GO:0016021	integral to membrane	IEA	--

ISLR2 for ontologies About GeneDecksing

ISLR2 Antibody Products:

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	Uscn Antibodies for ISLR2
	ThermoFisher Antibody for ISLR2

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	Uscn ELISAs and CLIAs for ISLR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ISLR2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR007110 Ig-like_dom

IPR000483 Cys-rich_flank_reg_C

IPR000372 LRR-contain_N

IPR003599 Ig_sub

IPR001611 Leu-rich_rpt

Graphical View of Domain Structure for InterPro Entry Q6UXK2

ProtoNet protein and cluster: Q6UXK2

3 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB000483 Cysteine-rich flanking region

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: ISLR2_HUMAN, Q6UXK2

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

Similarity: Contains 5 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 LRRNT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ISLR2_HUMAN, Q6UXK2

Function: Required for axon extension during neural development (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ISLR2 (see all 15):
		hsa-miR-3671 hsa-miR-607 hsa-miR-3152-3p hsa-miR-3194-5p hsa-miR-1197 hsa-miR-191* hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: ISLR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISLR2 (see all 4) OriGene shRNA RFP: ISLR2 OriGene siRNA: ISLR2
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

ISLR2 for ontologies About GeneDecksing

Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Islr2):

behavior/neurological

mortality/aging

nervous system

ISLR2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ISLR2

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0045773	positive regulation of axon extension	ISS	--

ISLR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ISLR2
Search CenterWatch for drugs/clinical trials and news about ISLR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ISLR2 gene (4 alternative transcripts):

NM_001130136.1 NM_001130137.1 NM_001130138.1 NM_020851.2

Unigene Cluster for ISLR2:

Immunoglobulin superfamily containing leucine-rich repeat 2

Hs.254775 [show with all ESTs]

Unigene Representative Sequence: BC152429

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000561975 ENST00000569886 ENST00000361742(uc002axd.3 uc002axe.3 uc010bjf.3)

ENST00000565068 ENST00000565159 ENST00000567206 ENST00000561740 ENST00000453268

ENST00000565332 ENST00000565540 ENST00000445793 ENST00000435464(uc010bjg.3)

ENST00000419208

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISLR2
		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ISLR2 (see all 15):
		hsa-miR-3671 hsa-miR-607 hsa-miR-3152-3p hsa-miR-3194-5p hsa-miR-1197 hsa-miR-191* hsa-miR-29a hsa-miR-29c

		SwitchGear 3'UTR luciferase reporter plasmid: ISLR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISLR2 (see all 4) OriGene shRNA RFP: ISLR2 OriGene siRNA: ISLR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISLR2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR2 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR2 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB040898.2 AK092297.1 AK092302.1 AK290467.1 AK309388.1 AY358316.1 BC028042.1 BC114551.1

BC152429.1

7 DOTS entries:

DT.100742761 DT.95111309 DT.100016851 DT.121079860 DT.100836032 DT.121079867 DT.121079864

24/32 AceView cDNA sequences (see all 32):

AX747460 BX442047 AX747465 BI917487 AK092302 BC028042 AB040898 BI914695

NM_020851 AK092297 AY358316 AW007241 BM839809 BM841956 BX095860 BX441838

BX452285 BM727467 BM011358 AK096602 AL134441 BX461894 R19055 BU852293

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ISLR2 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:			-		-		-		-		-		-								-
SP2:									-		-		-								-
SP3:											-		-								-
SP4:													-
SP5:																					-

ECgene alternative splicing isoforms for ISLR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ISLR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGACTCCA

About this image

ISLR2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Ventral/hypothalamic-like neurons (Generation of midbra...)

See ISLR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ISLR2

SOURCE GeneReport for Unigene cluster: Hs.254775

SABiosciences Custom PCR Arrays for ISLR2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ISLR2 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ISLR2¹	immunoglobulin superfamily containing leucine-rich more	63.41(n) 57.23(a)		429941 NM_001044667.1 NP_001038132.1
zebrafish (Danio rerio)	Actinopterygii	islr2¹	immunoglobulin superfamily containing leucine-rich more	54.62(n) 51.77(a)		541396 NM_001013523.1 NP_001013541.1
fruit fly (Drosophila melanogaster)	Insecta	kek4⁶ kek6⁶ (see all 6)	kek6 (see all 6)	15(a) 12(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2L(13212335-13215152) 3R(27447858-27490368)

ENSEMBL Gene Tree for ISLR2 (if available)
TreeFam Gene Tree for ISLR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ISLR2 gene

LRRC26² SLIT2² ISLR² LRRC17² LRIT2² SLIT1² LRRC52² LRTM1²

LRIT1² LRTM2² SLIT3² LRIT3² LRRC55² LRRC24² LRRC38²

8 SIMAP similar genes for ISLR2 using alignment to 5 protein entries: ISLR2_HUMAN (see all proteins):

ISLR LRIG3 PODNL1 LRRC4 SLIT2 TLR10

LINGO3 LINGO1

ISLR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141878758^1,2		--	74419798(+)	`AGCGCC/GAAGTA`	2	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs4454921^1,2	C,F,A,H,	--	74419809(+)	`GGGACA/CGCGCC`	2	--	nc-transcript-variantus2k¹		7		NS NA WA	912
rs12904268^1,2	C,F,H,	--	74420226(+)	`CTGGGT/GCTGTC`	3	--	us2k¹ nc-transcript-varianttfbs³		19		NS EA NA	2228
rs150608286^1,2		--	74420292(+)	`TCTGGG/TACCCT`	3	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs190804709^1,2		--	74420436(+)	`CAGCCC/TTCCCT`	3	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs139701330^1,2		--	74420727(+)	`GGCCCA/GCGGGA`	4	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs79925446^1,2	C,F,	--	74420796(+)	`CCTGCC/TGAACT`	5	--	us2k¹ nc-transcript-variant		1		WA	118
rs149788479^1,2		--	74420952(+)	`TTACCC/TAGATT`	5	--	us2k¹ nc-transcript-variant		0	--	--	--	--
rs2279379^1,2	C,F,A,H,	--	74421010(+)	`ACCGGC/GGGAGG`	5	--	int¹ us2k¹		14		EA NS NA WA CSA	1491
rs183039083^1,2		--	74421025(+)	`TGAGCC/TTCCCC`	5	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ISLR2 (74392652 - 74430881 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ISLR2
1 CNV: 3968
1 Inversion: 37170

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISLR2

DNA2.0 Custom Variant and Variant Library Synthesis for ISLR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ISLR2 for disorders           About GeneDecksing

OMIM gene information: 614179    OMIM disorders: --

1 disease for ISLR2:    About MalaCards

bardet-biedl syndrome

Export disorders for ISLR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ISLR2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ISLR2)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)² Nakajima D.... Nagase T. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57611	HGNC: 29286	AceView: KIAA1465	Ensembl:ENSG00000167178	euGenes: HUgn57611
ECgene: ISLR2	H-InvDB: ISLR2

(According to HUGE)
About This Section

HUGE: KIAA1465

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ISLR2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ISLR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ISLR2 gene:
Search GeneIP for patents involving ISLR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Custom Antibody & Bulk Services
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	Antibodies for ISLR2 (ISLR-2)		Browse Cell Culture Products
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	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for ISLR2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISLR2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISLR2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ISLR2		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
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	OriGene Custom Antibody Services for ISLR2		OriGene Custom Protein Services for ISLR2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ISLR2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISLR2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISLR2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISLR2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISLR2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISLR2

	GenScript Custom Purified and Recombinant Proteins Services for ISLR2		GenScript cDNA clones with any tag delivered in your preferred vector for ISLR2
	GenScript Custom Assay Services for ISLR2		GenScript Custom Superior Antibodies Services for ISLR2
	GenScript Custom overexpressing Cell Line Services for ISLR2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in ISLR2 promoter
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	RT² qPCR Primer Assay in human, mouse, rat ISLR2
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	SABiosciences Custom PCR Arrays for ISLR2

Search Tocris compounds for ISLR2

	Browse Sino Biological Proteins and Antibodies
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	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ISLR2 antibodies

	Search for Antibodies for ISLR2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for ISLR2
	Custom Antibody / Protein Production Service
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Browse ProSpec Recombinant Proteins

ISLR2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ISLR2

	Gene Synthesis
	Protein Engineering
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR2

	SwitchGear 3'UTR luciferase reporter plasmids for ISLR2
	SwitchGear Promoter luciferase reporter plasmids for ISLR2

ThermoFisher Antibody for ISLR2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISLR2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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ISLR2 Gene

immunoglobulin superfamily containing leucine-rich repeat...

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ISLR2 Gene

immunoglobulin superfamily containing leucine-rich repeat...

Aliasesfor ISLR2 gene

Summariesfor ISLR2 gene

Genomic Viewsfor ISLR2 gene

Proteinsfor ISLR2 gene

Protein Domains /Familiesfor ISLR2 gene

Functionfor ISLR2 gene

Pathways & Interactionsfor ISLR2 gene

Drugs & Compoundsfor ISLR2 gene

Transcriptsfor ISLR2 gene

Expression for ISLR2 gene

Orthologsfor ISLR2 gene

Paralogsfor ISLR2 gene

Genomic Variantsfor ISLR2 gene

Disorders / Diseasesfor ISLR2 gene

Publicationsfor ISLR2 gene

External Searches for ISLR2 gene

Genome Databases showing ISLR2 gene

Other Databases showing ISLR2 gene

Specialized Databases showing ISLR2 gene

Intellectual Propertyfor ISLR2 gene

Productsfor ISLR2 gene

View Random Gene

Aliases
for ISLR2 gene

Summaries
for ISLR2 gene

Genomic Views
for ISLR2 gene

Proteins
for ISLR2 gene

Protein Domains /
Families
for ISLR2 gene

Function
for ISLR2 gene

Pathways & Interactions
for ISLR2 gene

Drugs & Compounds
for ISLR2 gene

Transcripts
for ISLR2 gene

Expression
for ISLR2 gene

Orthologs
for ISLR2 gene

Paralogs
for ISLR2 gene

Genomic Variants
for ISLR2 gene

Disorders / Diseases
for ISLR2 gene

Publications
for ISLR2 gene

Intellectual Property
for ISLR2 gene

Products
for ISLR2 gene