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ISLR Gene

protein-coding   GIFtS: 48
GCID: GC15P074466

Immunoglobulin Superfamily Containing Leucine-Rich Repeat

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunoglobulin Superfamily Containing Leucine-Rich Repeat1 2
HsT175632
Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein2

External Ids:    HGNC: 61331   Entrez Gene: 36712   Ensembl: ENSG000001290097   OMIM: 6020595   UniProtKB: O144983   

Export aliases for ISLR gene to outside databases

Previous GC identifers: GC15P070487 GC15P067582 GC15P072042 GC15P072181 GC15P072253 GC15P051260


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ISLR Gene:
ISLR (immunoglobulin superfamily containing leucine-rich repeat) is a protein-coding gene. An important paralog of this gene is SLITRK5.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ISLR gene promoter:
         MZF-1   ZID   Tal-1beta   ATF6   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ISLR promoter sequence
   Search Chromatin IP Primers for ISLR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISLR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q23-q24

ISLR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISLR gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P074466:  view genomic region     (about GC identifiers)

Start:
74,466,012 bp from pter      End:
74,469,213 bp from pter
Size:
3,202 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ISLR_HUMAN, O14498 (See protein sequence)
Recommended Name: Immunoglobulin superfamily containing leucine-rich repeat protein precursor  
Size: 428 amino acids; 45997 Da
Developmental stage: Expressed in fetal lung and kidney

Explore the universe of human proteins at neXtProt for ISLR: NX_O14498

Explore proteomics data for ISLR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51, Asn309

  • See ISLR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_005536.1  NP_958934.1  

    ENSEMBL proteins: 
     ENSP00000249842   ENSP00000453884   ENSP00000453105   ENSP00000378550  

    ISLR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for ISLR
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    OriGene MassSpec for ISLR
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    Novus Biologicals ISLR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISLR

     
    Search eBioscience for Proteins for ISLR 

     
    antibodies-online proteins for ISLR (4 products) 

     
    antibodies-online peptides for ISLR

    ISLR Antibody Products:

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    Novus Biologicals ISLR Antibodies
    Abcam antibodies for ISLR
    Cloud-Clone Corp. Antibodies for ISLR
    ThermoFisher Antibody for ISLR
    antibodies-online antibodies for ISLR (16 products) 

    ISLR Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ISLR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ISLR
    Cloud-Clone Corp. CLIAs for ISLR
    Search eBioscience for ELISAs for ISLR 
    antibodies-online kits for ISLR (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O14498

    ProtoNet protein and cluster: O14498

    4 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: ISLR_HUMAN, O14498
    Similarity: Contains 1 Ig-like (immunoglobulin-like) domain
    Similarity: Contains 5 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with ISLR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for ISLR:
    immunoglobulin superfamily containing a leucine rich repeat,widely expressed,involved in cell adhesion,widely but
    differentially expressed,with two alternatively spliced identical isoforms,located in the critical region of BBS4

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ISLR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ISLR:
     Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ISLR

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ISLR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISLR (see all 16):
    hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidISLR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ISLR
    Predesigned siRNA for gene silencing in human, mouse, rat ISLR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ISLR

    Clone
    Products:
         
    OriGene clones in human, mouse for ISLR (see all 13)
    OriGene ORF clones in mouse, rat for ISLR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISLR (NM_005545)
    Sino Biological Human cDNA Clone for ISLR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISLR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISLR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ISLR
    Browse ESI BIO Cell Lines and PureStem Progenitors for ISLR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ISLR_HUMAN, O14498: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with ISLR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISLR
    Interactions:

        Search GeneGlobe Interaction Network for ISLR

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ISLR (ENSP000002498424) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC5BENSP000003343294STRING: ENSP00000334329
    VASNENSP000003068644STRING: ENSP00000306864
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion TAS9325048

    Find genes that share ontologies with ISLR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISLR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ISLR gene (2 alternative transcripts): 
    NM_005545.3  NM_201526.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000249842(uc002axg.1) ENST00000559510 ENST00000560862 ENST00000395118(uc002axh.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ISLR using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISLR (see all 16):
    hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidISLR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ISLR
    Predesigned siRNA for gene silencing in human, mouse, rat ISLR
    Clone
    Products:
         
    OriGene clones in human, mouse for ISLR (see all 13)
    OriGene ORF clones in mouse, rat for ISLR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ISLR (NM_005545)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISLR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISLR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ISLR
    OriGene qSTAR qPCR primer pairs in human, mouse for ISLR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISLR
      QuantiTect SYBR Green Assays in human, mouse, rat ISLR
      QuantiFast Probe-based Assays in human, mouse, rat ISLR

    Selected AceView cDNA sequences (see all 202):

    H62387 AW874653 CN480317 CN479638 AB003184 NM_005545 AL571055 BP346335 
    BP375008 BM721334 AA131558 AA284917 AA581667 BX324720 BQ721108 AB024536 
    NM_201526 BU783932 AW028096 BQ894279 BX360742 BP345918 CR620951 BF434410 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ISLR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAACGGGGC
    ISLR Expression
    About this image


    ISLR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 5 entries
             HyStem+TGFbeta3+GDF5-induced SK11 cells
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    ISLR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISLR Protein Expression

    UniProtKB/Swiss-Prot: ISLR_HUMAN, O14498
    Tissue specificity: Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small
    intestine, thyroid, adrenal cortex, testis, stomach and spinal cord

        Custom PCR Arrays for ISLR
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    QuantiFast Probe-based Assays in human, mouse, rat ISLR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ISLR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Islr1 , 5 immunoglobulin superfamily containing leucine-rich more1, 5 85.19(n)1
    90.39(a)1
      9 (31.63 cM)5
    269681  NM_012043.41  NP_036173.11 
     581562655 
    chicken
    (Gallus gallus)
    Aves ISLR1 immunoglobulin superfamily containing leucine-rich more 61.19(n)
    49.06(a)
      769957  XM_001233272.3  XP_001233273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii islr26
    immunoglobulin superfamily containing leucine-rich...
    24(a)
    1 → many
    25(23358505-23362472) ENSDARG00000051875
    fruit fly
    (Drosophila melanogaster)
    Insecta kek66
    kek26
    (see all 6)
    kekkon-2
    (see all 6)
    9(a)
    9(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    3R(27447858-27490368)
    2L(11606514-11626124)


    ENSEMBL Gene Tree for ISLR (if available)
    TreeFam Gene Tree for ISLR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ISLR gene
    SLITRK52  SLIT12  SLIT32  SLITRK62  LRRC382  SLIT22  LRRC262  SLITRK12  
    SLITRK42  LRTM12  LRRC522  LRRC172  SLITRK22  LRTM22  SLITRK32  LRRC552  
    ISLR22  LRRC242  
    10 SIMAP similar genes for ISLR using alignment to 3 protein entries:     ISLR_HUMAN (see all proteins):
    ISLR2    CPN2    SLIT3    LRFN5    LRRC3C    CHADL
    LRRC4B    PXDN    LRIT3    LGR4

    Find genes that share paralogs with ISLR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ISLR (see all 190)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0374544
    A colorectal cancer sample4--see VAR_0374542 D N mis40--------
    rs1126802821,2
    F--74464106(+) GGAGAC/TGAAGT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs96304171,2
    C,F,A,H--74464183(+) CTTACA/TGAGTG 1 -- us2k121Minor allele frequency- T:0.21NS EA NA WA CSA 2203
    rs755934801,2
    C,F--74464268(+) GGGGTC/TGCACA 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1890728011,2
    --74464313(+) GGAGGA/CGCTAT 1 -- us2k10--------
    rs1494757881,2
    --74464396(+) CCTGAG/TGTGCT 1 -- us2k10--------
    rs1430853981,2
    --74464420(+) GTGGGA/GTGGGA 1 -- us2k10--------
    rs1920696311,2
    --74464593(+) AACCCC/TGGATG 1 -- us2k10--------
    rs722385381,2
    C--74464676(+) ATGCA-/AGAGAGG 1 -- us2k10--------
    rs80243881,2
    C,H--74464709(+) GAGGGG/TGCTCT 1 -- us2k114Minor allele frequency- T:0.00NS EA NA WA CSA 517

    HapMap Linkage Disequilibrium report for ISLR (74466012 - 74469213 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ISLR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833054CNV Loss17160897
    nsv469619CNV Loss16826518
    dgv2404n71CNV Loss21882294
    nsv833053CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISLR
    DNA2.0 Custom Variant and Variant Library Synthesis for ISLR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602059    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ISLR:
    Bardet-Biedl syndrome

    Find genes that share disorders with ISLR           About GenesLikeMe


    Export disorders for ISLR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISLR gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ISLR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). (PubMed id 9325048)1, 2, 3 Nagasawa A.... Shimizu N. (Genomics 1997)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Human and mouse ISLR (immunoglobulin superfamily containing leucine- rich repeat) genes: genomic structure and tissue expression. (PubMed id 10512678)1, 2 Nagasawa A....Shimizu N. (Genomics 1999)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3671 HGNC: 6133 AceView: ISLR Ensembl:ENSG00000129009 euGenes: HUgn3671
    ECgene: ISLR H-InvDB: ISLR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ISLR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISLR gene:
    Search GeneIP for patents involving ISLR

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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