Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ISLR Gene

protein-coding GIFtS: 47
GCID: GC15P074466

immunoglobulin superfamily containing leucine-rich repeat

Explore 3 diseases affiliated with
ISLR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Immunoglobulin Superfamily Containing Leucine-Rich Repeat¹ ²
HsT17563¹ ²
Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein²

External Ids:	HGNC: 6133¹	Entrez Gene: 3671²	Ensembl: ENSG00000129009⁷	OMIM: 602059⁵	UniProtKB: O14498³

Export aliases for ISLR gene to outside databases

Previous GC identifers: GC15P070487 GC15P067582 GC15P072042 GC15P072181 GC15P072253 GC15P051260

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ISLR gene promoter:
MZF-1 ZID Tal-1beta ATF6 E47
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ISLR promoter sequence

Search SABiosciences Chromatin IP Primers for ISLR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISLR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23-q24 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q23-q24

ISLR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISLR gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P074466: view genomic region (about GC identifiers)

Start:	74,466,012 bp from pter	End:	74,469,213 bp from pter
Size:	3,202 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ISLR_HUMAN, O14498 (See protein sequence)

Recommended Name: Immunoglobulin superfamily containing leucine-rich repeat protein precursor

Size: 428 amino acids; 45997 Da

Subcellular location: Secreted (Potential)

Developmental stage: Expressed in fetal lung and kidney

Explore the universe of human proteins at neXtProt for ISLR: NX_O14498

ISLR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_005536.1 NP_958934.1

ENSEMBL proteins:

ENSP00000249842 ENSP00000453884 ENSP00000453105 ENSP00000378550

Human Recombinant Protein Products for ISLR:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ISLR OriGene Protein Over-expression Lysate (see all 2): ISLR OriGene Custom Protein Services for ISLR
	GenScript Custom Purified and Recombinant Proteins Services for ISLR
	Novus Biologicals ISLR Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ISLR

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

ISLR for ontologies About GeneDecksing

ISLR Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: ISLR OriGene Custom Antibody Services for ISLR
	GenScript Custom Superior Antibodies Services for ISLR
	Novus Biologicals ISLR Antibodies
	Abcam antibodies for ISLR
	Uscn Antibodies for ISLR
	ThermoFisher Antibody for ISLR

Assay Products for ISLR:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ISLR
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ISLR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ISLR for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR003598 Ig_sub2

IPR007110 Ig-like_dom

IPR000483 Cys-rich_flank_reg_C

IPR000372 LRR-contain_N

IPR001611 Leu-rich_rpt

Graphical View of Domain Structure for InterPro Entry O14498

ProtoNet protein and cluster: O14498

4 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB000483 Cysteine-rich flanking region

IPB003598 Immunoglobulin C-2 type

IPB013098 Immunoglobulin I-set

UniProtKB/Swiss-Prot: ISLR_HUMAN, O14498

Similarity: Contains 1 Ig-like (immunoglobulin-like) domain

Similarity: Contains 5 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 LRRNT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

Genatlas biochemistry entry for ISLR:

immunoglobulin superfamily containing a leucine rich repeat,widely expressed,involved in cell adhesion,widely but

differentially expressed,with two alternatively spliced identical isoforms,located in the critical region of BBS4

Phenotypes:
1 GenomeRNAi human phenotype for ISLR:

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ISLR

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ISLR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISLR
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ISLR (see all 16):
		hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: ISLR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISLR (see all 4) OriGene shRNA RFP: ISLR OriGene siRNA: ISLR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISLR
		Sirion Biotech Custom design and validation of potent shRNA sequences against ISLR

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ISLR
			Sirion Biotech Customized adenovirus for overexpression of ISLR Sirion Biotech Customized adenovirus for potent knockdown of ISLR

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ISLR (NM_005545)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISLR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISLR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ISLR
		Search LifeMap BioReagents cell lines for ISLR
		Sirion Biotech Customized stable knockdown cell line services for ISLR Sirion Biotech Customized inducible knockdown cell line services for ISLR Sirion Biotech Customized stable overexpressing cell line services for ISLR Sirion Biotech Customized inducible overexpressing cell line services for ISLR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ISLR

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	9325048

ISLR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ISLR
Search CenterWatch for drugs/clinical trials and news about ISLR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ISLR gene (2 alternative transcripts):

NM_005545.3 NM_201526.1

Unigene Clusters for ISLR:

Immunoglobulin superfamily containing leucine-rich repeat

Hs.699822 [show with all ESTs], Hs.744405 [show with all ESTs]

Unigene Representative Sequences: AK074668, NM_201526

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000249842(uc002axg.1) ENST00000559510 ENST00000560862 ENST00000395118(uc002axh.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): ISLR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISLR
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate ISLR (see all 16):
		hsa-let-7d hsa-miR-15a hsa-let-7c hsa-let-7g hsa-miR-424 hsa-let-7a hsa-miR-195 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: ISLR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISLR (see all 4) OriGene shRNA RFP: ISLR OriGene siRNA: ISLR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISLR
		Sirion Biotech Custom design and validation of potent shRNA sequences against ISLR

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ISLR (NM_005545)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISLR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISLR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISLR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ISLR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISLR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISLR

Additional cDNA sequence:

AB003184.1 AK223267.1 AK225606.1 BC022478.1

19 DOTS entries:

DT.100786972 DT.121079325 DT.100786971 DT.97802459 DT.121079328 DT.121079281 DT.95104714 DT.121079348

DT.97805803 DT.85104602 DT.100786967 DT.40225970 DT.121079352 DT.121079424 DT.121079351 DT.95234614

DT.100733224 DT.100786976 DT.217069

24/202 AceView cDNA sequences (see all 202):

CN479638 CR620951 AB024536 AL571055 AA864412 CA396186 AB003184 AA131558

AI016196 BQ448317 BM721334 BP375008 BP345918 BQ894279 NM_201526 CN480317

CR592993 CK429927 H62387 AA581667 AA284917 BP346335 AI831627 BF434410

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ISLR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAACGGGGC

About this image

ISLR expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Heart

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)

Bone, Cartilage

HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)

Bone

See ISLR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ISLR

SOURCE GeneReport for Unigene clusters: Hs.699822 Hs.744405

UniProtKB/Swiss-Prot: ISLR_HUMAN, O14498

Tissue specificity: Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small

intestine, thyroid, adrenal cortex, testis, stomach and spinal cord

SABiosciences Custom PCR Arrays for ISLR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISLR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ISLR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISLR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISLR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ISLR gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ISLR¹	immunoglobulin superfamily containing leucine-rich more	61.13(n) 48.81(a)		769957 XM_001233272.2 XP_001233273.1
zebrafish (Danio rerio)	Actinopterygii	islr2⁶	immunoglobulin superfamily containing leucine-rich...	24(a)	1 → many	25(23358505-23362472)
fruit fly (Drosophila melanogaster)	Insecta	kek3⁶ kek5⁶ (see all 6)	kekkon5 (see all 6)	9(a) 9(a) (see all 6)	many ↔ many many ↔ many (see all 6)	2L(15552723-15583579) X(19247218-19365947)

ENSEMBL Gene Tree for ISLR (if available)
TreeFam Gene Tree for ISLR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ISLR gene

LRRC26² SLIT2² LRRC17² LRIT2² SLIT1² LRRC52² LRTM1² LRIT1²

LRTM2² SLIT3² ISLR2² LRIT3² LRRC55² LRRC24² LRRC38²

11 SIMAP similar genes for ISLR using alignment to 3 protein entries: ISLR_HUMAN (see all proteins):

ISLR2 CPN2 SLIT3 LRFN5 LRRC3C CHADL

PXDN LGR4 LINGO1 LINGO3 LRFN4

ISLR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112680282^1,2		--	74464106(+)	`GGAGAC/TGAAGT`	1	--	us2k¹		1		CSA	2
rs9630417^1,2	C,F,A,H	--	74464183(+)	`CTTACA/TGAGTG`	1	--	us2k¹		21		NS EA NA WA CSA	2203
rs75593480^1,2	F	--	74464268(+)	`GGGGTC/TGCACA`	1	--	us2k¹		1		EA	120
rs189072801^1,2		--	74464313(+)	`GGAGGA/CGCTAT`	1	--	us2k¹		0	--	--	--	--
rs149475788^1,2		--	74464396(+)	`CCTGAG/TGTGCT`	1	--	us2k¹		0	--	--	--	--
rs143085398^1,2		--	74464420(+)	`GTGGGA/GTGGGA`	1	--	us2k¹		0	--	--	--	--
rs192069631^1,2		--	74464593(+)	`AACCCC/TGGATG`	1	--	us2k¹		0	--	--	--	--
rs72238538^1,2	C	--	74464676(+)	`ATGCA-/AGAGAGG`	1	--	us2k¹		0	--	--	--	--
rs8024388^1,2	C,H	--	74464709(+)	`GAGGGG/TGCTCT`	1	--	us2k¹		14		NS EA NA WA CSA	517
rs35462746^1,2	C,F	--	74464763(+)	`TTGCAG/AGCAGC`	1	--	us2k¹		3		NA	124

HapMap Linkage Disequilibrium report for ISLR (74466012 - 74469213 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ISLR
1 Inversion: 37170

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISLR

DNA2.0 Custom Variant and Variant Library Synthesis for ISLR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ISLR for disorders           About GeneDecksing

OMIM gene information: 602059    OMIM disorders: --

3 diseases for ISLR:    About MalaCards

bardet-biedl syndrome thyroiditis prostatitis

Export disorders for ISLR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ISLR gene integrated from 9 sources:
(articles sorted by number of sources associating them with ISLR)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). (PubMed id 9325048)^{1, 2, 3} Nagasawa A.... Shimizu N. (1997)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Human and mouse ISLR (immunoglobulin superfamily containing leucine- rich repeat) genes: genomic structure and tissue expression. (PubMed id 10512678)^{1, 2} Nagasawa A....Shimizu N. (1999)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3671	HGNC: 6133	AceView: ISLR	Ensembl:ENSG00000129009	euGenes: HUgn3671
ECgene: ISLR	H-InvDB: ISLR

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ISLR	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ISLR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ISLR gene:
Search GeneIP for patents involving ISLR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for ISLR		OriGene shRNA RFP for ISLR
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISLR		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISLR
	OriGene Protein Over-expression Lysate for ISLR		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for ISLR		OriGene 3'-UTR Clone for ISLR
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISLR
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for ISLR		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for ISLR		OriGene Custom Protein Services for ISLR
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ISLR
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISLR
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISLR
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISLR
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISLR
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISLR

	GenScript Custom Purified and Recombinant Proteins Services for ISLR		GenScript cDNA clones with any tag delivered in your preferred vector for ISLR
	GenScript Custom Assay Services for ISLR		GenScript Custom Superior Antibodies Services for ISLR
	GenScript Custom overexpressing Cell Line Services for ISLR		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in ISLR promoter
	Search Chromatin IP Primers for ISLR
	RT² qPCR Primer Assay in human, mouse, rat ISLR
	Search GNC Networks for ISLR
	SABiosciences Custom PCR Arrays for ISLR

Search Tocris compounds for ISLR

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	ISLR antibodies
	ISLR lysates

	Antibodies for ISLR
	See all of Abcam's Antibodies, Kits and Proteins for ISLR
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

ISLR Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for ISLR

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISLR

	SwitchGear 3'UTR luciferase reporter plasmids for ISLR
	SwitchGear Promoter luciferase reporter plasmids for ISLR

ThermoFisher Antibody for ISLR

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISLR

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ISLR

Sirion Biotech Customized:

	stable knockdown cell line services for ISLR
	inducible knockdown cell line services for ISLR
	design and validation of potent shRNA sequences against ISLR
	adenovirus for potent knockdown of ISLR
	adenovirus for overexpression of ISLR
	stable overexpressing cell line services for ISLR
	inducible overexpressing cell line services for ISLR

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ISLR gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

ISLR Gene

immunoglobulin superfamily containing leucine-rich repeat

Aliases
for ISLR gene

Summaries
for ISLR gene

Genomic Views
for ISLR gene

Proteins
for ISLR gene

Protein Domains /
Families
for ISLR gene

Function
for ISLR gene

Pathways & Interactions
for ISLR gene

Drugs & Compounds
for ISLR gene

Transcripts
for ISLR gene

Expression
for ISLR gene

Orthologs
for ISLR gene

Paralogs
for ISLR gene

Genomic Variants
for ISLR gene

Disorders / Diseases
for ISLR gene

Publications
for ISLR gene

External Searches for ISLR gene

Genome Databases showing ISLR gene

Other Databases showing ISLR gene

Specialized Databases showing ISLR gene

Intellectual Property
for ISLR gene

Products
for ISLR gene

View Random Gene

Advanced Search

Export list of displayed genes

ISLR Gene

immunoglobulin superfamily containing leucine-rich repeat

Aliasesfor ISLR gene

Summariesfor ISLR gene

Genomic Viewsfor ISLR gene

Proteinsfor ISLR gene

Protein Domains /Familiesfor ISLR gene

Functionfor ISLR gene

Pathways & Interactionsfor ISLR gene

Drugs & Compoundsfor ISLR gene

Transcriptsfor ISLR gene

Expression for ISLR gene

Orthologsfor ISLR gene

Paralogsfor ISLR gene

Genomic Variantsfor ISLR gene

Disorders / Diseasesfor ISLR gene

Publicationsfor ISLR gene

External Searches for ISLR gene

Genome Databases showing ISLR gene

Other Databases showing ISLR gene

Specialized Databases showing ISLR gene

Intellectual Propertyfor ISLR gene

Productsfor ISLR gene

View Random Gene

Aliases
for ISLR gene

Summaries
for ISLR gene

Genomic Views
for ISLR gene

Proteins
for ISLR gene

Protein Domains /
Families
for ISLR gene

Function
for ISLR gene

Pathways & Interactions
for ISLR gene

Drugs & Compounds
for ISLR gene

Transcripts
for ISLR gene

Expression
for ISLR gene

Orthologs
for ISLR gene

Paralogs
for ISLR gene

Genomic Variants
for ISLR gene

Disorders / Diseases
for ISLR gene

Publications
for ISLR gene

Intellectual Property
for ISLR gene

Products
for ISLR gene