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Aliases for ISLR Gene

Aliases for ISLR Gene

  • Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2 3 5
  • Mesenchymal Stromal Cell- And Fibroblast-Expressing Linx Paralogue 3
  • HsT17563 3
  • Meflin 3

External Ids for ISLR Gene

Previous GeneCards Identifiers for ISLR Gene

  • GC15P070487
  • GC15P067582
  • GC15P072042
  • GC15P072181
  • GC15P072253
  • GC15P074466
  • GC15P051260

Summaries for ISLR Gene

GeneCards Summary for ISLR Gene

ISLR (Immunoglobulin Superfamily Containing Leucine-Rich Repeat) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation. An important paralog of this gene is LRIT3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISLR Gene

Genomics for ISLR Gene

Regulatory Elements for ISLR Gene

Promoters for ISLR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ISLR on UCSC Golden Path with GeneCards custom track

Genomic Location for ISLR Gene

Chromosome:
15
Start:
74,173,671 bp from pter
End:
74,176,872 bp from pter
Size:
3,202 bases
Orientation:
Plus strand

Genomic View for ISLR Gene

Genes around ISLR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISLR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISLR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISLR Gene

Proteins for ISLR Gene

  • Protein details for ISLR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14498-ISLR_HUMAN
    Recommended name:
    Immunoglobulin superfamily containing leucine-rich repeat protein
    Protein Accession:
    O14498

    Protein attributes for ISLR Gene

    Size:
    428 amino acids
    Molecular mass:
    45997 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISLR Gene

Proteomics data for ISLR Gene at MOPED

Post-translational modifications for ISLR Gene

  • Glycosylation at Asn 51 and Asn 309

Other Protein References for ISLR Gene

Antibody Products

No data available for DME Specific Peptides for ISLR Gene

Domains & Families for ISLR Gene

Gene Families for ISLR Gene

Suggested Antigen Peptide Sequences for ISLR Gene

Graphical View of Domain Structure for InterPro Entry

O14498

UniProtKB/Swiss-Prot:

ISLR_HUMAN :
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ISLR: view

Function for ISLR Gene

Molecular function for ISLR Gene

GENATLAS Biochemistry:
immunoglobulin superfamily containing a leucine rich repeat,widely expressed,involved in cell adhesion,widely but differentially expressed,with two alternatively spliced identical isoforms,located in the critical region of BBS4
genes like me logo Genes that share phenotypes with ISLR: view

Animal Model Products

miRNA for ISLR Gene

miRTarBase miRNAs that target ISLR

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISLR Gene

Localization for ISLR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISLR Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISLR Gene COMPARTMENTS Subcellular localization image for ISLR gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ISLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with ISLR: view

Pathways & Interactions for ISLR Gene

genes like me logo Genes that share pathways with ISLR: view

Interacting Proteins for ISLR Gene

Gene Ontology (GO) - Biological Process for ISLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9325048
genes like me logo Genes that share ontologies with ISLR: view

No data available for SIGNOR curated interactions for ISLR Gene

Drugs & Compounds for ISLR Gene

No Compound Related Data Available

Transcripts for ISLR Gene

Unigene Clusters for ISLR Gene

Immunoglobulin superfamily containing leucine-rich repeat:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISLR Gene

No ASD Table

Relevant External Links for ISLR Gene

GeneLoc Exon Structure for
ISLR
ECgene alternative splicing isoforms for
ISLR

Expression for ISLR Gene

mRNA expression in normal human tissues for ISLR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ISLR Gene

This gene is overexpressed in Thyroid (20.2) and Uterus (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ISLR Gene



SOURCE GeneReport for Unigene cluster for ISLR Gene Hs.699822

mRNA Expression by UniProt/SwissProt for ISLR Gene

O14498-ISLR_HUMAN
Tissue specificity: Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord.
genes like me logo Genes that share expression patterns with ISLR: view

Protein tissue co-expression partners for ISLR Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ISLR Gene

Orthologs for ISLR Gene

This gene was present in the common ancestor of animals.

Orthologs for ISLR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISLR 36
  • 99 (a)
OneToOne
ISLR 35
  • 99.22 (n)
  • 99.07 (a)
cow
(Bos Taurus)
Mammalia ISLR 36
  • 89 (a)
OneToOne
ISLR 35
  • 86.91 (n)
  • 89.27 (a)
dog
(Canis familiaris)
Mammalia ISLR 35
  • 88.3 (n)
  • 91.41 (a)
ISLR 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Islr 35
  • 85.19 (n)
  • 90.39 (a)
Islr 16
Islr 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ISLR 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ISLR 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Islr 35
  • 84.67 (n)
  • 90.44 (a)
chicken
(Gallus gallus)
Aves ISLR 35
  • 61.19 (n)
  • 49.06 (a)
ISLR2 36
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii islr2 36
  • 24 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta kek1 36
  • 10 (a)
ManyToMany
kek2 36
  • 9 (a)
ManyToMany
kek3 36
  • 10 (a)
ManyToMany
kek4 36
  • 14 (a)
ManyToMany
kek5 36
  • 10 (a)
ManyToMany
kek6 36
  • 9 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
CSA.1672 36
  • 16 (a)
ManyToMany
Species with no ortholog for ISLR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISLR Gene

ENSEMBL:
Gene Tree for ISLR (if available)
TreeFam:
Gene Tree for ISLR (if available)

Paralogs for ISLR Gene

Paralogs for ISLR Gene

(10) SIMAP similar genes for ISLR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISLR: view

Variants for ISLR Gene

Sequence variations from dbSNP and Humsavar for ISLR Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_037454 A colorectal cancer sample
rs13259 -- 74,176,645(+) CCTTG(C/G)TGTTT utr-variant-3-prime
rs3181010 -- 74,176,872(+) ATGCC(A/C)CTCCG downstream-variant-500B
rs3848161 -- 74,176,756(-) AGAGG(G/T)TGCAG utr-variant-3-prime
rs3888004 -- 74,176,425(+) CTAAC(A/G)GGGCG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ISLR Gene

Variant ID Type Subtype PubMed ID
nsv469619 CNV Loss 16826518
nsv833053 CNV Loss 17160897
nsv833054 CNV Loss 17160897
dgv2404n71 CNV Loss 21882294

Variation tolerance for ISLR Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISLR Gene

HapMap Linkage Disequilibrium report
ISLR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISLR Gene

Disorders for ISLR Gene

Relevant External Links for ISLR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISLR

No disorders were found for ISLR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISLR Gene

Publications for ISLR Gene

  1. Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). (PMID: 9325048) Nagasawa A. … Shimizu N. (Genomics 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3

Products for ISLR Gene

Sources for ISLR Gene

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