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Aliases for ISLR Gene

Aliases for ISLR Gene

  • Immunoglobulin Superfamily Containing Leucine-Rich Repeat 2 3
  • Immunoglobulin Superfamily Containing Leucine-Rich Repeat Protein 3
  • HsT17563 3

External Ids for ISLR Gene

Summaries for ISLR Gene

GeneCards Summary for ISLR Gene

ISLR (Immunoglobulin Superfamily Containing Leucine-Rich Repeat) is a Protein Coding gene. Diseases associated with ISLR include bardet-biedl syndrome. An important paralog of this gene is SLITRK3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISLR Gene

Genomics for ISLR Gene

Genomic Location for ISLR Gene

74,173,671 bp from pter
74,176,872 bp from pter
3,202 bases
Plus strand

Genomic View for ISLR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISLR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISLR Gene

Regulatory Elements for ISLR Gene

Proteins for ISLR Gene

  • Protein details for ISLR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily containing leucine-rich repeat protein
    Protein Accession:
    Secondary Accessions:

    Protein attributes for ISLR Gene

    428 amino acids
    Molecular mass:
    45997 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISLR Gene

Proteomics data for ISLR Gene at MOPED

Post-translational modifications for ISLR Gene

  • Glycosylation at Asn51 and Asn309

Other Protein References for ISLR Gene

No data available for DME Specific Peptides for ISLR Gene

Domains for ISLR Gene

Gene Families for ISLR Gene

  • ISET :Immunoglobulin superfamily / I-set domain containing


  • Contains 1 Ig-like (immunoglobulin-like) domain.:
    • O14498
  • Contains 1 LRRCT domain.:
    • O14498
  • Contains 1 LRRNT domain.:
    • O14498
  • Contains 5 LRR (leucine-rich) repeats.:
    • O14498
genes like me logo Genes that share domains with ISLR: view

Function for ISLR Gene

Molecular function for ISLR Gene

GENATLAS Biochemistry: immunoglobulin superfamily containing a leucine rich repeat,widely expressed,involved in cell adhesion,widely but differentially expressed,with two alternatively spliced identical isoforms,located in the critical region of BBS4

Gene Ontology (GO) - Molecular Function for ISLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ISLR: view

Phenotypes for ISLR Gene

GenomeRNAi human phenotypes for ISLR:
genes like me logo Genes that share phenotypes with ISLR: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ISLR Gene

Localization for ISLR Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISLR Gene


Subcellular locations from

Jensen Localization Image for ISLR Gene COMPARTMENTS Subcellular localization image for ISLR gene
Compartment Confidence
extracellular 3
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ISLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ISLR: view

Pathways for ISLR Gene

SuperPathways for ISLR Gene

No Data Available

Interacting Proteins for ISLR Gene

Gene Ontology (GO) - Biological Process for ISLR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 9325048
genes like me logo Genes that share ontologies with ISLR: view

No data available for Pathways by source for ISLR Gene

Transcripts for ISLR Gene

Unigene Clusters for ISLR Gene

Immunoglobulin superfamily containing leucine-rich repeat:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISLR Gene

No ASD Table

Relevant External Links for ISLR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISLR Gene

mRNA expression in normal human tissues for ISLR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ISLR Gene

SOURCE GeneReport for Unigene cluster for ISLR Gene Hs.699822

mRNA Expression by UniProt/SwissProt for ISLR Gene

Tissue specificity: Expressed in various tissues including retina, heart, skeletal muscle, prostate, ovary, small intestine, thyroid, adrenal cortex, testis, stomach and spinal cord.
genes like me logo Genes that share expressions with ISLR: view

Orthologs for ISLR Gene

This gene was present in the common ancestor of animals.

Orthologs for ISLR Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ISLR 36
  • 99.22 (n)
  • 99.07 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ISLR 36
  • 86.91 (n)
  • 89.27 (a)
  • 89 (a)
(Canis familiaris)
Mammalia ISLR 36
  • 88.3 (n)
  • 91.41 (a)
  • 81 (a)
(Mus musculus)
Mammalia Islr 36
  • 85.19 (n)
  • 90.39 (a)
Islr 16
Islr 37
  • 86 (a)
(Monodelphis domestica)
Mammalia ISLR 37
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ISLR 37
  • 58 (a)
(Rattus norvegicus)
Mammalia Islr 36
  • 84.67 (n)
  • 90.44 (a)
(Gallus gallus)
Aves ISLR 36
  • 61.19 (n)
  • 49.06 (a)
ISLR2 37
  • 28 (a)
(Danio rerio)
Actinopterygii islr2 37
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta kek1 37
  • 10 (a)
kek2 37
  • 9 (a)
kek3 37
  • 10 (a)
kek4 37
  • 14 (a)
kek5 37
  • 10 (a)
kek6 37
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 15 (a)
-- 37
  • 25 (a)
CSA.1672 37
  • 16 (a)
Species with no ortholog for ISLR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISLR Gene

Gene Tree for ISLR (if available)
Gene Tree for ISLR (if available)

Paralogs for ISLR Gene

Selected SIMAP similar genes for ISLR Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISLR: view

Variants for ISLR Gene

Sequence variations from dbSNP and Humsavar for ISLR Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs12287 -- 74,176,654(+) TTTCT(G/T)ATGAT utr-variant-3-prime
rs13259 -- 74,176,645(+) CCTTG(C/G)TGTTT utr-variant-3-prime
rs923118 -- 74,173,930(+) CGCCC(G/T)TGGCC utr-variant-5-prime, upstream-variant-2KB
rs1052622 -- 74,175,515(+) GGTAC(A/G)CCGCT synonymous-codon, reference
rs1063734 -- 74,174,975(+) TACCG(C/T)GACCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ISLR Gene

Variant ID Type Subtype PubMed ID
nsv469619 CNV Loss 16826518
nsv833053 CNV Loss 17160897
nsv833054 CNV Loss 17160897
dgv2404n71 CNV Loss 21882294

Relevant External Links for ISLR Gene

HapMap Linkage Disequilibrium report

Disorders for ISLR Gene

(1) MalaCards Diseases for ISLR Gene

Search for ISLR Gene in MalaCards »

(1) University of Copenhagen DISEASES for ISLR Gene

genes like me logo Genes that share disorders with ISLR: view

No data available for UniProtKB/Swiss-Prot for ISLR Gene

Publications for ISLR Gene

  1. Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR). (PMID: 9325048) Nagasawa A. … Shimizu N. (Genomics 1997) 2 3 4
  2. Human and mouse ISLR (immunoglobulin superfamily containing leucine- rich repeat) genes: genomic structure and tissue expression. (PMID: 10512678) Nagasawa A. … Shimizu N. (Genomics 1999) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4

Products for ISLR Gene

Sources for ISLR Gene

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