Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ISL2 Gene

protein-coding   GIFtS: 48
GCID: GC15P076629

ISL LIM Homeobox 2

(Previous names: ISL2 transcription factor, LIM/homeodomain, (islet-2))
  See ISL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
ISL LIM Homeobox 21 2
ISL2 Transcription Factor, LIM/Homeodomain, (Islet-2)1 2
Insulin Gene Enhancer Protein ISL-22
islet-22
Islet-23

External Ids:    HGNC: 185241   Entrez Gene: 648432   Ensembl: ENSG000001595567   OMIM: 6094815   UniProtKB: Q96A473   

Export aliases for ISL2 gene to outside databases

Previous GC identifers: GC15P072517 GC15P069719 GC15P074205 GC15P074344 GC15P074416 GC15P053386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ISL2 Gene:
ISL2 (ISL LIM homeobox 2) is a protein-coding gene. Diseases associated with ISL2 include cortical blindness. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ISL1.

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal
cord and select distinct axon pathways (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NC_018926.2  NT_010194.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISL2 gene promoter:
         AML1a   Pax-5   Pax-2   Pax-2a   NF-kappaB   N-Myc   POU2F1   POU2F1a   Cart-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISL2 promoter sequence
   Search Chromatin IP Primers for ISL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24.3

ISL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P076629:  view genomic region     (about GC identifiers)

Start:
76,629,065 bp from pter      End:
76,634,817 bp from pter
Size:
5,753 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47 (See protein sequence)
Recommended Name: Insulin gene enhancer protein ISL-2  
Size: 359 amino acids; 39768 Da
Subunit: Interacts with LHX4 (By similarity)
Secondary accessions: B3KM37

Explore the universe of human proteins at neXtProt for ISL2: NX_Q96A47

Explore proteomics data for ISL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ISL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_665804.1  
    ENSEMBL proteins: 
     ENSP00000290759   ENSP00000453837  

    ISL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ISL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ISL2
    GenScript Custom Purified and Recombinant Proteins Services for ISL2
    Novus Biologicals ISL2 Proteins
    Novus Biologicals ISL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISL2

     
    Search eBioscience for Proteins for ISL2 

     
    antibodies-online proteins for ISL2 (7 products) 

     
    antibodies-online peptides for ISL2

    ISL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ISL2 (Islet-2)
    OriGene Antibodies for ISL2
    OriGene Custom Antibody Services for ISL2
    Novus Biologicals ISL2 Antibodies
    Search for Antibodies for ISL2 at Abcam
    Cloud-Clone Corp. Antibodies for ISL2
    Search ThermoFisher Antibodies for ISL2
    antibodies-online antibodies for ISL2 (45 products) 

    ISL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ISL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ISL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ISL2
    Cloud-Clone Corp. CLIAs for ISL2
    Search eBioscience for ELISAs for ISL2 
    antibodies-online kits for ISL2 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    LIM: Homeoboxes / LIM class

    4 InterPro protein domains:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q96A47

    ProtoNet protein and cluster: Q96A47

    1 Blocks protein domain: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Find genes that share domains with ISL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISL2_HUMAN, Q96A47
    Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal
    cord and select distinct axon pathways (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS17091338
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with ISL2           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Isl2):
     cellular  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 
     normal  respiratory system 

    Find genes that share phenotypes with ISL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Isl2tm2Slp for ISL2

       genOway: Develop your customized and physiologically relevant rodent model for ISL2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ISL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISL2 (see all 15):
    hsa-miR-3673 hsa-miR-206 hsa-miR-622 hsa-miR-627 hsa-miR-26b* hsa-miR-4299 hsa-miR-1 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidISL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ISL2
    Predesigned siRNA for gene silencing in human, mouse, rat ISL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ISL2

    Clone
    Products:
         
    OriGene clones in human, mouse for ISL2 (see all 5)
    OriGene ORF clones in mouse, rat for ISL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ISL2 (NM_145805)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ISL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ISL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ISL2_HUMAN, Q96A47: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IC17091338

    Find genes that share ontologies with ISL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including ISL2: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ISL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ISL2 (Q96A473 ENSP000002907594) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LHX3Q9UBR43, ENSP000003608114I2D: score=3 STRING: ENSP00000360811
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    LDB2O436793, ENSP000003067724I2D: score=1 STRING: ENSP00000306772
    LHX4Q969G23, ENSP000002637264I2D: score=1 STRING: ENSP00000263726
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0021520spinal cord motor neuron cell fate specification IEA--
    GO:0021524visceral motor neuron differentiation IEA--
    GO:0031290retinal ganglion cell axon guidance IEA--
    GO:0045665negative regulation of neuron differentiation IEA--

    Find genes that share ontologies with ISL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ISL2 gene: 
    NM_145805.1  

    Unigene Cluster for ISL2:

    ISL LIM homeobox 2
    Hs.444677  [show with all ESTs]
    Unigene Representative Sequence: AB593133
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290759(uc002bbw.1 uc021sqw.1) ENST00000558656 ENST00000558437

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ISL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISL2 (see all 15):
    hsa-miR-3673 hsa-miR-206 hsa-miR-622 hsa-miR-627 hsa-miR-26b* hsa-miR-4299 hsa-miR-1 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidISL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ISL2
    Predesigned siRNA for gene silencing in human, mouse, rat ISL2
    Clone
    Products:
         
    OriGene clones in human, mouse for ISL2 (see all 5)
    OriGene ORF clones in mouse, rat for ISL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ISL2 (NM_145805)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ISL2
    OriGene qSTAR qPCR primer pairs in human, mouse for ISL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISL2
      QuantiTect SYBR Green Assays in human, mouse, rat ISL2
      QuantiFast Probe-based Assays in human, mouse, rat ISL2

    Additional mRNA sequence: 

    AB593133.1 AK001022.1 BC011967.1 BC012136.1 

    3 DOTS entries:

    DT.305214  DT.75175862  DT.65287319 

    24 AceView cDNA sequences:

    AK001022 BQ881714 BC012136 NM_145805 AA459822 CR610026 BC011967 BU849219 
    BM827241 AU118412 BX327471 BE783453 BE778146 AI936027 BU553385 BU845300 
    AL559453 AA776817 AL559452 AA459702 BG472783 BX280469 BU553899 AU144983 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ISL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCTGGGA
    ISL2 Expression
    About this image


    ISL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neurons
             Lateral Neurons of the Median Motor Column Median Motor Column
             Motor neuron-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 16 entries
             Lateral Neurons of the Median Motor Column Median Motor Column
             Motor neuron-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 9 entries
             Somatic Motor Neurons Motor Neural Progenitor Domain
             Metencephalon
             N2-induced embryoid bodies
     
     Motor Neurons (Nervous System)    fully expand to see all 4 entries
             Motor neuron-like cells
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
    ISL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444677
        Pathway & Disease-focused RT2 Profiler PCR Array including ISL2: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ISL2
    OriGene qSTAR qPCR primer pairs in human, mouse for ISL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISL2
    QuantiTect SYBR Green Assays in human, mouse, rat ISL2
    QuantiFast Probe-based Assays in human, mouse, rat ISL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ISL2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isl21 , 5 insulin related protein 2 (islet 2)1, 5 93.41(n)1
    98.61(a)1
      9 (30.13 cM)5
    1043601  NM_027397.31  NP_081673.21 
     555386725 
    zebrafish
    (Danio rerio)
    Actinopterygii isl22 islet2 81.06(n)   30157  D38453.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tup3 terminal region determination specific
    RNA polymerase more
    65(a)   2 37B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea lim-73 homeobox protein 36(a)   I(5724813-5733493)   --


    ENSEMBL Gene Tree for ISL2 (if available)
    TreeFam Gene Tree for ISL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ISL2 gene
    ISL12  LHX22  LHX92  LMX1B2  LHX52  LHX62  LHX12  LMX1A2  
    LHX42  LHX32  LHX82  
    17 SIMAP similar genes for ISL2 using alignment to 3 protein entries:     ISL2_HUMAN (see all proteins):
    ISL1    LHx4    LMO1    DKFZp686P2249    LMO3    LMO2
    LHX4    LHX8    LHX2    LHX9    LHX1    LMX1A
    LHX6    LMO4    ABLIM1    LMX1B    LHX5

    Find genes that share paralogs with ISL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ISL2 (see all 174)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1449996741,2
    --56679027(+) CCCGGC/TGCGGT 1 -- us2k10--------
    rs124408151,2
    C,F,A,H--56679174(+) GCTCGC/ACTGCA 1 -- us2k110Minor allele frequency- A:0.29NA WA CSA EA 373
    rs118559991,2
    C,F,H--56679179(+) CCTGCA/CATCTC 1 -- us2k16Minor allele frequency- C:0.48NA WA EA 248
    rs284475741,2
    C--56679182(+) GCAATC/TTCAGC 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs562840541,2
    C--56679329(+) AAAAA-/A/AAA 
    AAAAAAAA
    GCCGG
    1 -- us2k11NA 2
    rs1812203451,2
    --56679393(+) CGCTAC/GTGGAC 1 -- us2k10--------
    rs1431371971,2
    --56679396(+) TACTGA/GACGAG 1 -- us2k10--------
    rs1387403461,2
    --56679425(+) AGCGCA/GGGGCC 1 -- us2k10--------
    rs118560791,2
    C,F,H--56679452(+) CGTGGA/GCCATG 1 -- us2k11Minor allele frequency- G:0.20WA 118
    rs1864986671,2
    --56679526(+) CCCTCC/GGCTGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ISL2 (76629065 - 76634817 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ISL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749895CNV Deletion23290073
    esv2749898CNV Deletion23290073
    nsv1619CNV Insertion18451855
    nsv904399CNV Loss21882294
    nsv525769CNV Loss19592680
    nsv827391CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ISL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609481    OMIM disorders: --

    1 disease for ISL2:    
    About MalaCards
    cortical blindness

    1 disease from the University of Copenhagen DISEASES database for ISL2:
    Cortical blindness

    Find genes that share disorders with ISL2           About GenesLikeMe


    Export disorders for ISL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ISL2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ISL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice. (PubMed id 21190559)1 Tsigankov D. and Koulakov A.A. (BMC Neurosci 2010)
    6. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    7. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    10. Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein. (PubMed id 17091338)1 Li Y....Liu M. (Mol. Biol. Rep. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64843 HGNC: 18524 AceView: ISL2 Ensembl:ENSG00000159556 euGenes: HUgn64843
    ECgene: ISL2 H-InvDB: ISL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ISL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ISL2 gene:
    Search GeneIP for patents involving ISL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for ISL2 (Islet-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ISL2   OriGene RNAi products in human, mouse, rat for ISL2  
     OriGene qPCR primer pairs and template standards for ISL2   OriGene Protein Over-expression Lysate for ISL2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ISL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ISL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ISL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ISL2   OriGene Custom Protein Services for ISL2  

     
     
     Block miRNA regulation of human, mouse, rat ISL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ISL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISL2 Predesigned siRNA for gene silencing in human, mouse, rat ISL2
     QuantiFast Probe-based Assays in human, mouse, rat ISL2 QuantiTect SYBR Green Assays in human, mouse, rat ISL2
     PCR Arrays including human, mouse, rat ISL2 Search Chromatin IP Primers for ISL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISL2  Search GeneGlobe Interaction Network for ISL2
     Regulatory tfbs in ISL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ISL2 GenScript cDNA clones with any tag delivered in your preferred vector for ISL2
     GenScript Custom Assay Services for ISL2 GenScript Custom overexpressing Cell Line Services for ISL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ISL2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ISL2 antibodies
     ISL2 proteins
     ISL2 lysates
     Search for Antibodies for ISL2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ISL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ISL2
     Antibodies for ISL2
     ELISAs for ISL2
     CLIAs for ISL2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ISL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL2
     SwitchGear 3'UTR luciferase reporter plasmids for ISL2
     SwitchGear Promoter luciferase reporter plasmids for ISL2
     Search ThermoFisher Antibodies for ISL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL2
     Browse compounds at ApexBio
     Search Addgene for plasmids for ISL2
      Search eBioscience for proteins for ISL2
      Search eBioscience for elisas for ISL2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ISL2
     antibodies-online antibodies for ISL2 (45 products)
     antibodies-online kits for ISL2 (8 products)
     antibodies-online peptides for ISL2
     antibodies-online proteins for ISL2 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ISL2 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4