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Aliases for ISL2 Gene

Aliases for ISL2 Gene

  • ISL LIM Homeobox 2 2 3
  • ISL2 Transcription Factor, LIM/Homeodomain, (Islet-2) 2 3
  • Islet-2 3 4
  • Insulin Gene Enhancer Protein ISL-2 3

External Ids for ISL2 Gene

Previous GeneCards Identifiers for ISL2 Gene

  • GC15P072517
  • GC15P069719
  • GC15P074205
  • GC15P074344
  • GC15P074416
  • GC15P076629
  • GC15P053386

Summaries for ISL2 Gene

GeneCards Summary for ISL2 Gene

ISL2 (ISL LIM Homeobox 2) is a Protein Coding gene. Diseases associated with ISL2 include cortical blindness. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LHX4.

UniProtKB/Swiss-Prot for ISL2 Gene

  • Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISL2 Gene

Genomics for ISL2 Gene

Regulatory Elements for ISL2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ISL2 Gene

Start:
76,336,724 bp from pter
End:
76,342,476 bp from pter
Size:
5,753 bases
Orientation:
Plus strand

Genomic View for ISL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISL2 Gene

Proteins for ISL2 Gene

  • Protein details for ISL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A47-ISL2_HUMAN
    Recommended name:
    Insulin gene enhancer protein ISL-2
    Protein Accession:
    Q96A47
    Secondary Accessions:
    • B3KM37

    Protein attributes for ISL2 Gene

    Size:
    359 amino acids
    Molecular mass:
    39768 Da
    Quaternary structure:
    • Interacts with LHX4.

neXtProt entry for ISL2 Gene

Proteomics data for ISL2 Gene at MOPED

Post-translational modifications for ISL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ISL2 Gene

Domains for ISL2 Gene

Gene Families for ISL2 Gene

HGNC:
  • LIM :Homeoboxes / LIM class

Protein Domains for ISL2 Gene

Suggested Antigen Peptide Sequences for ISL2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96A47

UniProtKB/Swiss-Prot:

ISL2_HUMAN :
  • Q96A47
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with ISL2: view

Function for ISL2 Gene

Molecular function for ISL2 Gene

UniProtKB/Swiss-Prot Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

Gene Ontology (GO) - Molecular Function for ISL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS 17091338
GO:0008270 zinc ion binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ISL2: view
genes like me logo Genes that share phenotypes with ISL2: view

Animal Models for ISL2 Gene

MGI Knock Outs for ISL2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ISL2 Gene

Localization for ISL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISL2 Gene COMPARTMENTS Subcellular localization image for ISL2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ISL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IC 17091338
genes like me logo Genes that share ontologies with ISL2: view

Pathways for ISL2 Gene

SuperPathways for ISL2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ISL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0021520 spinal cord motor neuron cell fate specification IEA --
GO:0021524 visceral motor neuron differentiation IEA --
GO:0031290 retinal ganglion cell axon guidance IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with ISL2: view

No data available for Pathways by source for ISL2 Gene

Transcripts for ISL2 Gene

mRNA/cDNA for ISL2 Gene

Unigene Clusters for ISL2 Gene

ISL LIM homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ISL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISL2 Gene

No ASD Table

Relevant External Links for ISL2 Gene

GeneLoc Exon Structure for
ISL2
ECgene alternative splicing isoforms for
ISL2

Expression for ISL2 Gene

mRNA expression in normal human tissues for ISL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISL2 Gene

This gene is overexpressed in Vagina (5.5), Esophagus - Gastroesophageal Junction (4.9), Whole Blood (4.4), and Pituitary (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISL2 Gene

SOURCE GeneReport for Unigene cluster for ISL2 Gene Hs.444677

genes like me logo Genes that share expressions with ISL2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ISL2 Gene

Orthologs for ISL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISL2 35
  • 99.81 (n)
  • 100 (a)
ISL2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ISL2 35
  • 95.17 (n)
  • 98.33 (a)
ISL2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ISL2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Isl2 35
  • 93.41 (n)
  • 98.61 (a)
Isl2 16
Isl2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ISL2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ISL2 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Isl2 35
  • 92.57 (n)
  • 96.66 (a)
zebrafish
(Danio rerio)
Actinopterygii isl2 35
isl2a 35
  • 76.42 (n)
  • 88.02 (a)
isl2a 36
  • 88 (a)
OneToMany
isl2b 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta tup 36
  • 39 (a)
OneToMany
tup 37
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea lim-7 36
  • 33 (a)
OneToMany
lim-7 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for ISL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ISL2 Gene

ENSEMBL:
Gene Tree for ISL2 (if available)
TreeFam:
Gene Tree for ISL2 (if available)

Paralogs for ISL2 Gene

Paralogs for ISL2 Gene

Selected SIMAP similar genes for ISL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISL2: view

Variants for ISL2 Gene

Sequence variations from dbSNP and Humsavar for ISL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs874223 -- 76,339,230(+) ATCCG(C/T)AGACC intron-variant
rs874224 -- 76,339,456(+) CAAGC(C/G)GGTAT intron-variant
rs1810348 -- 76,340,146(-) TTTAA(C/T)TGTTC intron-variant
rs2003344 -- 76,339,960(-) GTCGC(A/G)GGACC intron-variant
rs2203821 -- 76,336,827(-) GTCGC(A/G)CGCCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ISL2 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv1619 CNV Insertion 18451855
nsv904399 CNV Loss 21882294
nsv827391 CNV Gain 20364138
nsv525769 CNV Loss 19592680

Relevant External Links for ISL2 Gene

HapMap Linkage Disequilibrium report
ISL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISL2 Gene

Disorders for ISL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ISL2 Gene including...

Search for ISL2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ISL2 Gene

genes like me logo Genes that share disorders with ISL2: view

No data available for UniProtKB/Swiss-Prot for ISL2 Gene

Publications for ISL2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PMID: 15302935) Beausoleil S.A. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3
  4. The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors. (PMID: 9452425) Jurata L.W. … Gill G.N. (J. Biol. Chem. 1998) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ISL2 Gene

Sources for ISL2 Gene

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