Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ISL2 Gene

protein-coding   GIFtS: 47
GCID: GC15P076629

ISL LIM homeobox 2

(Previous names: ISL2 transcription factor, LIM/homeodomain, (islet-2) )
 Explore 6 diseases affiliated with
ISL2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ISL2    

Aliases
for ISL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ISL LIM Homeobox 21 2
ISL2 Transcription Factor, LIM/Homeodomain, (Islet-2)1 2
FLJ101601
Insulin Gene Enhancer Protein ISL-22
Islet-23
Islet-23

External Ids:    HGNC: 185241   Entrez Gene: 648432   Ensembl: ENSG000001595567   OMIM: 6094815   UniProtKB: Q96A473   

Export aliases for ISL2 gene to outside databases

Previous GC identifers: GC15P072517 GC15P069719 GC15P074205 GC15P074344 GC15P074416 GC15P053386


Summaries
for ISL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord
and select distinct axon pathways (By similarity)




Genomic Views
for ISL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ISL2 gene promoter:
         AML1a   Pax-5   Pax-2   Pax-2a   NF-kappaB   N-Myc   POU2F1   POU2F1a   Cart-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ISL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ISL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q23   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24.3

ISL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISL2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P076629:  view genomic region     (about GC identifiers)

Start:
 76,629,065 bp from pter      End:
 76,634,817 bp from pter
Size:
 5,753 bases      Orientation:
 plus strand

Proteins
for ISL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47 (See protein sequence)
Recommended Name: Insulin gene enhancer protein ISL-2  
Size: 359 amino acids; 39768 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: B3KM37

Explore the universe of human proteins at neXtProt for ISL2: NX_Q96A47

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96A47

    • ISL2 Protein expression data from MOPED and PaxDb:    About this image 
    ISL2 Protein Expression
    REFSEQ proteins: NP_665804.1  
    ENSEMBL proteins: 
     ENSP00000290759   ENSP00000453837   ENSP00000452985  

    Human Recombinant Protein Products for ISL2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: ISL2
    OriGene Custom Protein Services for ISL2 
    GenScript Custom Purified and Recombinant Proteins Services for ISL2
    Novus Biologicals ISL2 Proteins
    Novus Biologicals ISL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ISL2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IC17091338

    ISL2 for ontologies           About GeneDecksing



    ISL2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ISL2 (Islet-2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ISL2 
    GenScript Custom Superior Antibodies Services for ISL2
    Novus Biologicals ISL2 Antibodies
    Abcam antibodies for ISL2 
    Uscn Antibodies for ISL2
    Search ThermoFisher Antibodies for ISL2

    Assay Products for ISL2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ISL2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ISL2

    Protein Domains /
    Families
    for ISL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ISL2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001781 Znf_LIM
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q96A47

    ProtoNet protein and cluster: Q96A47

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: ISL2_HUMAN, Q96A47
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 2 LIM zinc-binding domains


    Function
    for ISL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISL2_HUMAN, Q96A47
    Function: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord
    and select distinct axon pathways (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS17091338
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    ISL2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Isl2):
     cellular  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     normal  respiratory system 

    ISL2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Isl2tm2Slp for ISL2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ISL2 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISL2
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ISL2 (see all 15):
    hsa-miR-3673 hsa-miR-206 hsa-miR-622 hsa-miR-627 hsa-miR-26b* hsa-miR-4299 hsa-miR-1 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmid: ISL2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISL2 (see all 7)
    OriGene shRNA RFP: ISL2
    OriGene siRNA: ISL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISL2
    Sirion Biotech Custom design and validation of potent shRNA sequences against ISL2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ISL2
    Sirion Biotech Customized adenovirus for overexpression of ISL2 
    Sirion Biotech Customized adenovirus for potent knockdown of ISL2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISL2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ISL2 (NM_145805)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ISL2
    Search LifeMap BioReagents cell lines for ISL2
    Sirion Biotech Customized stable knockdown cell line services for ISL2 
    Sirion Biotech Customized inducible knockdown cell line services for ISL2
    Sirion Biotech Customized stable overexpressing cell line services for ISL2
    Sirion Biotech Customized inducible overexpressing cell line services for ISL2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL2


    Pathways & Interactions
    for ISL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ISL2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/8 Interacting proteins for ISL2 (Q96A473 ENSP000002907594) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LHX3Q9UBR43, ENSP000003608114I2D: score=3 STRING: ENSP00000360811
    ISL1P613713, ENSP000002306584I2D: score=2 STRING: ENSP00000230658
    LDB1Q86U703, ENSP000003924664I2D: score=1 STRING: ENSP00000392466
    LDB2O436793I2D: score=1 
    LHX4Q969G23I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0021520spinal cord motor neuron cell fate specification IEA--
    GO:0021524visceral motor neuron differentiation IEA--
    GO:0031290retinal ganglion cell axon guidance IEA--
    GO:0045665negative regulation of neuron differentiation IEA--
    GO:0048663neuron fate commitment ----

    ISL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ISL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ISL2
    Search CenterWatch for drugs/clinical trials and news about ISL2 

    Transcripts
    for ISL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ISL2 gene: 
    NM_145805.1  

    Unigene Cluster for ISL2:

    ISL LIM homeobox 2
    Hs.444677  [show with all ESTs]
    Unigene Representative Sequence: AB593133
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290759(uc002bbw.1 uc021sqw.1) ENST00000558656 ENST00000558437


    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISL2
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate ISL2 (see all 15):
    hsa-miR-3673 hsa-miR-206 hsa-miR-622 hsa-miR-627 hsa-miR-26b* hsa-miR-4299 hsa-miR-1 hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmid: ISL2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISL2 (see all 7)
    OriGene shRNA RFP: ISL2
    OriGene siRNA: ISL2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISL2
    Sirion Biotech Custom design and validation of potent shRNA sequences against ISL2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISL2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ISL2 (NM_145805)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISL2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ISL2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISL2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISL2

    Additional cDNA sequence: 

    AB593133.1 AK001022.1 BC011967.1 BC012136.1 

    3 DOTS entries:

    DT.305214  DT.75175862  DT.65287319 

    24 AceView cDNA sequences:

    NM_145805 AK001022 BC011967 CR610026 AA459822 BQ881714 BC012136 BE783453 
    BX327471 BU849219 BU553385 AU118412 BM827241 BU845300 BE778146 AI936027 
    AL559452 AL559453 AA776817 AA459702 BX280469 BG472783 AU144983 BU553899 

    GeneLoc Exon Structure


    Expression
    for ISL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ISL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTGCTGGGA
    ISL2 Expression
    About this image

    ISL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    Spinal CordCaudal Brachial Lateral Motor DivisionLateral Neurons Of The LMCMotor Neurons
    Spinal CordCaudal Brachial Medial Motor DivisionMedial Neurons of The LMCMotor Neurons
    Spinal CordHypaxial Motor ColumnHypaxial Motor NeuronsMotor Neurons
    Spinal CordLumbar Lateral Motor DivisionLateral Neurons of the LMCMotor Neurons
    Spinal CordLumbar Medial Motor DivisionMedial Neurons of the LMCMotor Neurons
    Spinal CordMedian Motor ColumnLateral Neurons of the Median Motor ColumnMotor Neurons
    Spinal CordMedian Motor ColumnMedial Neurons of the Median Motor ColumnMotor Neurons
    Spinal CordMedian Motor ColumnMedian Motor NeuronsMotor Neurons
    Spinal CordMotor Neural Progenitor DomainMotor Neural Progenitor CellsMotor Neurons
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Motor neuron-like cells (Generation of motor ...)
    Motor neuron-like cells (Generation of motor ...)
    N2-induced embryoid bodies (Generation of motor ...)
    Motor neuron progenitors (Generation of motor ...)
    Motor neuron-like cells (Spinal motor neurons...)

    See ISL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ISL2

    SOURCE GeneReport for Unigene cluster: Hs.444677
        SABiosciences Expression via Pathway-Focused PCR Array including ISL2: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISL2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ISL2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISL2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISL2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL2

    Orthologs
    for ISL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ISL2 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1N959_CHICK6
    		 Uncharacterized protein
    		 65(a)
    		 1 ↔ 1
    		 Z(14559796-14572244)
    zebrafish
    (Danio rerio)    		 Actinopterygii isl22 islet2 81.06(n)   30157  D38453.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta tup3 terminal region determination specific RNA
    polymerase more    		 65(a)   2 37B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea lim-73 homeobox protein 36(a)   I(5724813-5733493)   --


    ENSEMBL Gene Tree for ISL2 (if available)
    TreeFam Gene Tree for ISL2 (if available) 

    Paralogs
    for ISL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ISL2 gene
    LMO22  ISL12  LHX22  LHX92  LMX1B2  LMO12  LHX52  LMO42  
    LHX62  LHX12  LMX1A2  LMO32  LHX42  LHX32  LHX82  
    18/23 SIMAP similar genes for ISL2 using alignment to 4 protein entries:     ISL2_HUMAN (see all proteins) (see all similar genes):
    ISL1    LHx4    LMO1    DKFZp686P2249    LMO3    LHX4
    LMO2    LHX2    LHX9    LHX8    LHX1    LHX6
    LMO4    LMX1A    LMX1B    ABLIM1    LDB3    ABLIM2

    ISL2 for paralogs           About GeneDecksing



    Genomic Variants
    for ISL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ISL2

    Disorders / Diseases
    for ISL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ISL2 for disorders           About GeneDecksing

    OMIM gene information: 609481    OMIM disorders: --

    6 diseases for ISL2:    About MalaCards
    aphasia    constipation    keratoconus    pharyngitis
    neuronitis    retinitis

    1 disease from the University of Copenhagen DISEASES database for ISL2:
    Cortical blindness

    Export disorders for ISL2 gene to outside databases

    Publications
    for ISL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ISL2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ISL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Sperry versus Hebb: topographic mapping in Isl2/EphA3 mutant mice. (PubMed id 21190559)1 Tsigankov D. and Koulakov A.A. (2010)
    6. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Cloning and expression of a novel human gene, Isl-2, encoded a LIM-homeodomain protein. (PubMed id 17091338)1 Li Y....Liu M. (2007)
    10. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)

    External Searches for ISL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ISL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64843 HGNC: 18524 AceView: ISL2 Ensembl:ENSG00000159556 euGenes: HUgn64843
    ECgene: ISL2 H-InvDB: ISL2

    Other Databases showing ISL2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ISL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ISL2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ISL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ISL2 gene:
    Search GeneIP for patents involving ISL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ISL2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for ISL2 (Islet-2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ISL2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISL2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISL2  
     OriGene Protein Over-expression Lysate for ISL2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ISL2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISL2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISL2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ISL2   OriGene Custom Protein Services for ISL2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ISL2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISL2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISL2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISL2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISL2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISL2
     GenScript Custom Purified and Recombinant Proteins Services for ISL2 GenScript cDNA clones with any tag delivered in your preferred vector for ISL2
     GenScript Custom Assay Services for ISL2 GenScript Custom Superior Antibodies Services for ISL2
     GenScript Custom overexpressing Cell Line Services for ISL2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ISL2 promoter
     Search Chromatin IP Primers for ISL2
     RT2 qPCR Primer Assay in human, mouse, rat ISL2
     Search GNC Networks for ISL2
     SABiosciences PCR Arrays including human, mouse, rat ISL2
     Search Tocris compounds for ISL2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ISL2 antibodies
     ISL2 proteins
     ISL2 lysates
     Antibodies for ISL2
     See all of Abcam's Antibodies, Kits and Proteins for ISL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ISL2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ISL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL2
     SwitchGear 3'UTR luciferase reporter plasmids for ISL2
     SwitchGear Promoter luciferase reporter plasmids for ISL2
     Search ThermoFisher Antibodies for ISL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ISL2
    Sirion Biotech Customized:
     stable knockdown cell line services for ISL2
     inducible knockdown cell line services for ISL2
     design and validation of potent shRNA sequences against ISL2
     adenovirus for potent knockdown of ISL2
     adenovirus for overexpression of ISL2
     stable overexpressing cell line services for ISL2
     inducible overexpressing cell line services for ISL2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ISL2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4