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Aliases for ISL2 Gene

Aliases for ISL2 Gene

  • ISL LIM Homeobox 2 2 3 5
  • ISL2 Transcription Factor, LIM/Homeodomain, (Islet-2) 2 3
  • Islet-2 3 4

External Ids for ISL2 Gene

Previous GeneCards Identifiers for ISL2 Gene

  • GC15P072517
  • GC15P069719
  • GC15P074205
  • GC15P074344
  • GC15P074416
  • GC15P076629
  • GC15P053386

Summaries for ISL2 Gene

GeneCards Summary for ISL2 Gene

ISL2 (ISL LIM Homeobox 2) is a Protein Coding gene. Among its related pathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is LHX4.

UniProtKB/Swiss-Prot for ISL2 Gene

  • Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISL2 Gene

Genomics for ISL2 Gene

Regulatory Elements for ISL2 Gene

Enhancers for ISL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ISL2 on UCSC Golden Path with GeneCards custom track

Promoters for ISL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ISL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ISL2 Gene

76,335,942 bp from pter
76,342,476 bp from pter
6,535 bases
Plus strand

Genomic View for ISL2 Gene

Genes around ISL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISL2 Gene

Proteins for ISL2 Gene

  • Protein details for ISL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin gene enhancer protein ISL-2
    Protein Accession:
    Secondary Accessions:
    • B3KM37

    Protein attributes for ISL2 Gene

    359 amino acids
    Molecular mass:
    39768 Da
    Quaternary structure:
    • Interacts with LHX4.

neXtProt entry for ISL2 Gene

Proteomics data for ISL2 Gene at MOPED

Post-translational modifications for ISL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISL2 Gene

Domains & Families for ISL2 Gene

Gene Families for ISL2 Gene

Protein Domains for ISL2 Gene

Suggested Antigen Peptide Sequences for ISL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
  • Contains 2 LIM zinc-binding domains.
genes like me logo Genes that share domains with ISL2: view

Function for ISL2 Gene

Molecular function for ISL2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.
genes like me logo Genes that share phenotypes with ISL2: view

Animal Models for ISL2 Gene

MGI Knock Outs for ISL2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ISL2 Gene

Localization for ISL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISL2 Gene

Subcellular locations from

Jensen Localization Image for ISL2 Gene COMPARTMENTS Subcellular localization image for ISL2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ISL2 Gene

Pathways & Interactions for ISL2 Gene

genes like me logo Genes that share pathways with ISL2: view

Pathways by source for ISL2 Gene

Gene Ontology (GO) - Biological Process for ISL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021520 spinal cord motor neuron cell fate specification IEA --
GO:0021524 visceral motor neuron differentiation IEA --
GO:0031290 retinal ganglion cell axon guidance IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
GO:0048935 peripheral nervous system neuron development TAS 20096094
genes like me logo Genes that share ontologies with ISL2: view

No data available for SIGNOR curated interactions for ISL2 Gene

Drugs & Compounds for ISL2 Gene

No Compound Related Data Available

Transcripts for ISL2 Gene

mRNA/cDNA for ISL2 Gene

Unigene Clusters for ISL2 Gene

ISL LIM homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISL2 Gene

No ASD Table

Relevant External Links for ISL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISL2 Gene

mRNA expression in normal human tissues for ISL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISL2 Gene

This gene is overexpressed in Vagina (x5.5), Esophagus - Gastroesophageal Junction (x4.9), Whole Blood (x4.4), and Pituitary (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISL2 Gene

SOURCE GeneReport for Unigene cluster for ISL2 Gene Hs.444677

genes like me logo Genes that share expression patterns with ISL2: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ISL2 Gene

Orthologs for ISL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ISL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ISL2 35
  • 95.17 (n)
  • 98.33 (a)
ISL2 36
  • 99 (a)
(Mus musculus)
Mammalia Isl2 35
  • 93.41 (n)
  • 98.61 (a)
Isl2 16
Isl2 36
  • 99 (a)
(Pan troglodytes)
Mammalia ISL2 35
  • 99.81 (n)
  • 100 (a)
ISL2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Isl2 35
  • 92.57 (n)
  • 96.66 (a)
(Canis familiaris)
Mammalia ISL2 36
  • 93 (a)
(Monodelphis domestica)
Mammalia ISL2 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia ISL2 36
  • 68 (a)
(Danio rerio)
Actinopterygii isl2 35
isl2a 35
  • 76.42 (n)
  • 88.02 (a)
isl2a 36
  • 88 (a)
isl2b 36
  • 86 (a)
fruit fly
(Drosophila melanogaster)
Insecta tup 37
  • 65 (a)
tup 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea lim-7 37
  • 36 (a)
lim-7 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for ISL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ISL2 Gene

Gene Tree for ISL2 (if available)
Gene Tree for ISL2 (if available)

Paralogs for ISL2 Gene

Paralogs for ISL2 Gene

(17) SIMAP similar genes for ISL2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISL2: view

Variants for ISL2 Gene

Sequence variations from dbSNP and Humsavar for ISL2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs874223 -- 76,339,230(+) ATCCG(C/T)AGACC intron-variant, nc-transcript-variant
rs874224 -- 76,339,456(+) CAAGC(C/G)GGTAT intron-variant, nc-transcript-variant
rs12440815 -- 76,334,987(+) GCTCG(A/C)CTGCA upstream-variant-2KB
rs7174377 -- 76,339,702(+) TGTTG(C/T)AAGCC intron-variant, nc-transcript-variant
rs1810348 -- 76,340,146(-) TTTAA(C/T)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ISL2 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv1619 CNV Insertion 18451855
nsv904399 CNV Loss 21882294
nsv827391 CNV Gain 20364138
nsv525769 CNV Loss 19592680

Variation tolerance for ISL2 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.84% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ISL2 Gene

Disorders for ISL2 Gene

Relevant External Links for ISL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ISL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISL2 Gene

Publications for ISL2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3
  4. Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation. (PMID: 20096094) Dykes I.M. … Turner E.E. (Neural Dev 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for ISL2 Gene

Sources for ISL2 Gene