ISL1 Gene

Aliases
for ISL1 gene

Previous GC identifers: GC05P050856 GC05P052121 GC05P050649 GC05P050695 GC05P047642

Summaries
for ISL1 gene

Genomic Views
for ISL1 gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_006713.15  

SwitchGear Promoter luciferase reporter plasmid: ISL1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISL1

ISL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P050714:  view genomic region     (about GC identifiers)

Proteins
for ISL1 gene

Explore the universe of human proteins at neXtProt for ISL1: NX_P61371

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ISL1 OriGene Custom Protein Services for ISL1
	GenScript Custom Purified and Recombinant Proteins Services for ISL1
	Novus Biologicals ISL1 Proteins Novus Biologicals ISL1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ISL1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of ISL1
	R&D Systems Antibodies for ISL1 (Islet-1)
	OriGene Antibodies: ISL1 OriGene Custom Antibody Services for ISL1
	GenScript Custom Superior Antibodies Services for ISL1
	Novus Biologicals ISL1 Antibodies
	Abcam antibodies for ISL1
	Uscn Antibodies for ISL1
	ThermoFisher Antibody for ISL1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ISL1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ISL1

Protein Domains /
Families
for ISL1 gene

ProtoNet protein and cluster: P61371

Function
for ISL1 gene

miRNA Products:		OriGene 3'-UTR Clone: ISL1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISL1
		8/61 QIAGEN miScript miRNA Assays for microRNAs that regulate ISL1 (see all 61):
		hsa-miR-4291 hsa-miR-576-3p hsa-miR-4328 hsa-miR-513a-5p hsa-miR-517a hsa-miR-29a hsa-miR-605 hsa-miR-128
		SwitchGear 3'UTR luciferase reporter plasmid: ISL1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISL1 (see all 7) OriGene shRNA RFP: ISL1 OriGene siRNA: ISL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISL1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ISL1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ISL1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ISL1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ISL1 (NM_002202)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISL1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISL1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ISL1
		Search LifeMap BioReagents cell lines for ISL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL1

Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

15/17 MGI mutant phenotypes (inferred from 11 alleles) (MGI details for Isl1)

Pathways & Interactions
for ISL1 gene

	Super-pathway	contained gene-specific pathways
1	Neural Crest Differentiation	Neural Crest Differentiation 1.00
2	Heart Development	Heart Development 1.00
3	Transcriptional Regulatory Network in Embryonic Stem Cell	Transcriptional Regulatory Network in Embryonic Stem Cell 1.00
4	Type II diabetes mellitus	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics 0.38

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ISL1

Transcriptional Regulatory Network in Embryonic Stem Cell

2 BioSystems Pathways for ISL1

	Heart Development
	Neural Crest Differentiation

1 PharmGKB Pathway for ISL1

Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

Gene Ontology (GO): 5/55 biological process terms (GO ID links to tree view) (see all 55):    About this table

Drugs & Compounds
for ISL1 gene

Transcripts
for ISL1 gene

Expression
for ISL1 gene

ISL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCATTTGACA

10/66 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 66)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	EyeGanglion Cell LayerImmature Ganglion Cells			Ganglion, Retina
	EyeGanglion Cell LayerMature Ganglion Cells			Ganglion, Retina
	Head MesenchymePrechordal MesenchymePrechordal Mesoderm Cells			Skeletal Muscle
	HeartMyocardiumCardiomyocytes			Myocardium
	HeartMyocardiumCardiomyocytes Progenitor Cells			Myocardium
	HeartOutflow TractCardiomyocytes			Myocardium
	HeartRight VentricleCardiomyocytes			Myocardium
	Lateral Plate MesodermSplanchnic MesodermSplanchnic Mesoderm Cells			Mesoderm
	PancreasDorsal Pancreatic BudPancreatic Progenitor Cells			Pancreas
	PancreasDorsal Pancreatic MesenchymeDorsal Pancreatic Mesenchymal Cells			Mesoderm
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/25 LifeMap Cells (see all 25)
	Name			Category
	Yolk sac (Scl -/-) (Primary Cell)			Extraembryonic Tissues
	Endoderm progenitor-like cells (Generation and expan...)
	Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
	Cardiomyocyte-like cells (Cardiomyocyte genera...)
	Cardiac mesoderm embryoid bodies (Cardiomyocyte genera...)
	Cardiomyocyte-like progenitor cells (Derivation of cardio...)
	Mesoderm-like cells (Derivation of cardio...)
	DKK1-induced cells (Derivation of cardio...)
	BMP4-induced embryoid bodies (Cardiac differentiat...)
	Beating embryoid bodies (Cardiac differentiat...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ISL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ISL1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISL1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISL1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISL1

Orthologs
for ISL1 gene

Paralogs
for ISL1 gene

Paralogs for ISL1 gene

LMO2²  LHX2²  LHX9²  LMX1B²  LMO1²  LHX5²  LMO4²  LHX6²  

LHX1²  LMX1A²  LMO3²  LHX4²  LHX3²  LHX8²  ISL2²  

16 SIMAP similar genes for ISL1 using alignment to 3 protein entries:     ISL1_HUMAN (see all proteins):

ISL2    LHx4    LMO3    LMO4    LMO1    LHX6

LHX4    LMO2    LHX2    LHX1    LHX8    LMX1A

LHX3    LHX9    LHX5    CDX1

ISL1 for paralogs           About GeneDecksing

Genomic Variants
for ISL1 gene

10/221 NCBI SNPs in ISL1 are shown (see all 221)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1162220821,2	C,F,	untested	47642877(+)	GAGAGG/ATGCCC	1	--	ut51		1		NA	120
rs1219122861,2	C,	untested	47649368(+)	GCCCAA/GTGACA	2	N S	mis1		1		EU	1271
rs1219135401,2	C,F,	other	47649126(+)	CTGCGG/ACCCCA	2	/R	syn1		1		EU	1107
rs1219135411,2	C,F,	other	47649180(+)	CTGAAC/TGAGAA	2	N	syn1		1		EU	1317
rs2020321201,2	C	--	47640941(+)	GGTATC/TTTTTT	1	--	us2k1		0	--	--	--	--
rs765684141,2	F,	--	47641070(+)	AAAGGC/TTCCAT	1	--	us2k1		1		NA	120
rs602747071,2	C,F	--	47641126(+)	AAAAAC/ACACAC	1	--	us2k1		3		NA WA CSA	6
rs362168961,2	C,F,	--	47641761(-)	CAGAAC/TAGTGA	1	--	us2k1		3		WA CSA	122
rs362168941,2	C,F,	--	47641811(-)	TTTTTT/AAAAAA	1	--	us2k1		1		WA	118
rs100798021,2	C,F,H,	--	47641974(+)	ATTTCG/ACTCTT	1	--	us2k1		6		NS NA WA	910

HapMap Linkage Disequilibrium report for ISL1 (50678921 - 50690564 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ISL1: --
Human Gene Mutation Database (HGMD): ISL1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISL1

DNA2.0 Custom Variant and Variant Library Synthesis for ISL1

Disorders / Diseases
for ISL1 gene

19 diseases for ISL1

3 Novoseek disease relationships for ISL1 gene    About this table

Publications
for ISL1 gene

PubMed articles for ISL1 gene, integrated from 9 sources (see all 91): (articles sorted by number of sources associating them with ISL1)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism. (PubMed id 7912209)^{1, 2, 3, 9} Tanizawa Y.... Permutt M.A. (1994)
2. The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage. (PubMed id 7907017)^{1, 2, 9} Wang M. and Drucker D.J. (1994)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Hepatocyte nuclear factor 4 alpha ligand binding and F domains mediate interaction and transcriptional synergy with the pancreatic islet LIM HD transcription factor Isl1. (PubMed id 17022998)^{1, 9} Eeckhoute J....Laine B. (2006)
5. Islet cell and extrapancreatic expression of the LIM domain homeobox gene isl-1. (PubMed id 1685766)^{1, 9} Dong J....Drucker D.J. (1991)
6. Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. (PubMed id 17519333)^{1, 9} Lin L....Evans S.M. (2007)
7. Multipotential nestin and Isl-1 positive mesenchymal stem cells isolated from human pancreatic islets. (PubMed id 16713999)^{1, 9} Eberhardt M....Zulewski H. (2006)
8. ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells. (PubMed id 16321656)^{1, 9} Peng S.Y....Zhou C.Y. (2005)
9. The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin. (PubMed id 17363077)^{1, 9} Suzuki C....Oiso Y. (2007)
10. Islet-1: a potentially important role for an islet cell gene in visceral fat. (PubMed id 18239644)^{1, 9} Li H....Chisholm D.J. (2008)

External Searches for ISL1 gene

Genome Databases showing ISL1 gene

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Products
for ISL1 gene