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Aliases for ISG20L2 Gene

Aliases for ISG20L2 Gene

  • Interferon Stimulated Exonuclease Gene 20kDa-Like 2 2 3
  • Interferon-Stimulated 20 KDa Exonuclease-Like 2 3
  • EC 3.1.-.- 4
  • HSD38 3

External Ids for ISG20L2 Gene

Previous GeneCards Identifiers for ISG20L2 Gene

  • GC01M153506
  • GC01M154959
  • GC01M156691
  • GC01M128049

Summaries for ISG20L2 Gene

Entrez Gene Summary for ISG20L2 Gene

  • This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]

GeneCards Summary for ISG20L2 Gene

ISG20L2 (Interferon Stimulated Exonuclease Gene 20kDa-Like 2) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ISG20.

UniProtKB/Swiss-Prot for ISG20L2 Gene

  • 3-> 5-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3-end containing a free hydroxyl group.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISG20L2 Gene

Genomics for ISG20L2 Gene

Regulatory Elements for ISG20L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ISG20L2 Gene

156,721,891 bp from pter
156,728,799 bp from pter
6,909 bases
Minus strand

Genomic View for ISG20L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISG20L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISG20L2 Gene

Proteins for ISG20L2 Gene

  • Protein details for ISG20L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-stimulated 20 kDa exonuclease-like 2
    Protein Accession:
    Secondary Accessions:
    • D3DVC6
    • Q64KA2

    Protein attributes for ISG20L2 Gene

    353 amino acids
    Molecular mass:
    39154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISG20L2 Gene

Proteomics data for ISG20L2 Gene at MOPED

Post-translational modifications for ISG20L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISG20L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISG20L2 Gene

Domains for ISG20L2 Gene

Protein Domains for ISG20L2 Gene

Suggested Antigen Peptide Sequences for ISG20L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H9L3
  • Contains 1 exonuclease domain.
genes like me logo Genes that share domains with ISG20L2: view

No data available for Gene Families for ISG20L2 Gene

Function for ISG20L2 Gene

Molecular function for ISG20L2 Gene

UniProtKB/Swiss-Prot Function: 3-> 5-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3-end containing a free hydroxyl group.

Enzyme Numbers (IUBMB) for ISG20L2 Gene

Gene Ontology (GO) - Molecular Function for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004527 exonuclease activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ISG20L2: view

Phenotypes for ISG20L2 Gene

genes like me logo Genes that share phenotypes with ISG20L2: view

Animal Model Products

CRISPR Products

miRNA for ISG20L2 Gene

miRTarBase miRNAs that target ISG20L2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ISG20L2 Gene

Localization for ISG20L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG20L2 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for ISG20L2 Gene COMPARTMENTS Subcellular localization image for ISG20L2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

Pathways for ISG20L2 Gene

SuperPathways for ISG20L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

No data available for Pathways by source for ISG20L2 Gene

Transcripts for ISG20L2 Gene

Unigene Clusters for ISG20L2 Gene

Interferon stimulated exonuclease gene 20kDa-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ISG20L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ISG20L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -
SP3: - -

Relevant External Links for ISG20L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ISG20L2 Gene

mRNA expression in normal human tissues for ISG20L2 Gene

mRNA differential expression in normal tissues according to GTEx for ISG20L2 Gene

This gene is overexpressed in Testis (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISG20L2 Gene

SOURCE GeneReport for Unigene cluster for ISG20L2 Gene Hs.301904

genes like me logo Genes that share expressions with ISG20L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ISG20L2 Gene

Orthologs for ISG20L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISG20L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ISG20L2 35
  • 98.01 (n)
  • 98.58 (a)
ISG20L2 36
  • 100 (a)
(Bos Taurus)
Mammalia ISG20L2 35
  • 88.7 (n)
  • 88.51 (a)
ISG20L2 36
  • 88 (a)
(Canis familiaris)
Mammalia ISG20L2 35
  • 87.26 (n)
  • 87.93 (a)
ISG20L2 36
  • 88 (a)
(Mus musculus)
Mammalia Isg20l2 35
  • 78.5 (n)
  • 74.72 (a)
Isg20l2 16
Isg20l2 36
  • 70 (a)
(Monodelphis domestica)
Mammalia ISG20L2 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia ISG20L2 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Isg20l2 35
  • 79.26 (n)
  • 75.85 (a)
(Anolis carolinensis)
Reptilia ISG20L2 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia isg20l2 35
  • 55.93 (n)
  • 52.58 (a)
(Danio rerio)
Actinopterygii isg20l2 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for ISG20L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISG20L2 Gene

Gene Tree for ISG20L2 (if available)
Gene Tree for ISG20L2 (if available)

Paralogs for ISG20L2 Gene

Paralogs for ISG20L2 Gene

Selected SIMAP similar genes for ISG20L2 Gene using alignment to 1 proteins: Pseudogenes for ISG20L2 Gene

genes like me logo Genes that share paralogs with ISG20L2: view

Variants for ISG20L2 Gene

Sequence variations from dbSNP and Humsavar for ISG20L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1133856 -- 156,723,343(-) TGGCA(A/G)TGGGG utr-variant-3-prime
rs4593815 -- 156,722,886(+) acagg(C/T)gtgag utr-variant-3-prime
rs4618960 -- 156,722,514(+) gcccg(C/T)ctcgg downstream-variant-500B, utr-variant-3-prime
rs11443455 -- 156,722,278(+) TTTTT(-/T)GAGAC downstream-variant-500B, utr-variant-3-prime
rs11579761 -- 156,723,226(+) TAGAG(C/G)TTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ISG20L2 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897

Relevant External Links for ISG20L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG20L2 Gene

Disorders for ISG20L2 Gene

No disorders were found for ISG20L2 Gene.

No data available for UniProtKB/Swiss-Prot for ISG20L2 Gene

Publications for ISG20L2 Gene

  1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. (PMID: 18065403) Coute Y. … Diaz J.-J. (Mol. Cell. Proteomics 2008) 2 3 4
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for ISG20L2 Gene

Sources for ISG20L2 Gene

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