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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ISG20L2 Gene

protein-coding   GIFtS: 50
GCID: GC01M156691

Interferon Stimulated Exonuclease Gene 20kDa-Like 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Stimulated Exonuclease Gene 20kDa-Like 21 2
Interferon-Stimulated 20 KDa Exonuclease-Like 22
EC 3.1.-.-3

External Ids:    HGNC: 257451   Entrez Gene: 818752   Ensembl: ENSG000001433197   OMIM: 6119305   UniProtKB: Q9H9L33   

Export aliases for ISG20L2 gene to outside databases

Previous GC identifers: GC01M153506 GC01M154959 GC01M128049


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ISG20L2 Gene: 
ISG20L2 (interferon stimulated exonuclease gene 20kDa-like 2) is a protein-coding gene. Diseases associated with ISG20L2 include yellow fever, and hepatitis a. GO annotations related to this gene include exonuclease activity and nucleic acid binding. An important paralog of this gene is ISG20.

UniProtKB/Swiss-Prot: I20L2_HUMAN, Q9H9L3
Function: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays
a strong specificity for a 3'-end containing a free hydroxyl group




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ISG20L2 gene promoter:
         E2F-3a   E2F-4   STAT1   E2F-5   E2F-2   STAT1alpha   E2F   E2F-1   Ik-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISG20L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ISG20L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISG20L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

ISG20L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISG20L2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156691:  view genomic region     (about GC identifiers)

Start:
156,691,683 bp from pter      End:
156,698,591 bp from pter
Size:
6,909 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: I20L2_HUMAN, Q9H9L3 (See protein sequence)
Recommended Name: Interferon-stimulated 20 kDa exonuclease-like 2  
Size: 353 amino acids; 39154 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: D3DVC6 Q64KA2

Explore the universe of human proteins at neXtProt for ISG20L2: NX_Q9H9L3

Explore proteomics data for ISG20L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H9L3

  • ISG20L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ISG20L2 Protein Expression
    REFSEQ proteins: NP_112242.1  
    ENSEMBL proteins: 
     ENSP00000323424   ENSP00000357202  

    Human Recombinant Protein Products for ISG20L2: 
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    Novus Biologicals ISG20L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISG20L2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ISG20L2 for ontologies           About GeneDecksing



    ISG20L2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H9L3

    ProtoNet protein and cluster: Q9H9L3

    1 Blocks protein domain: IPB006055 Exonuclease

    UniProtKB/Swiss-Prot: I20L2_HUMAN, Q9H9L3
    Similarity: Contains 1 exonuclease domain


    ISG20L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I20L2_HUMAN, Q9H9L3
    Function: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays
    a strong specificity for a 3'-end containing a free hydroxyl group

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004527exonuclease activity IEA--
    GO:0005515protein binding IPI16189514
         
    ISG20L2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ISG20L2:
     Decreased TP53 protein express  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ISG20L2 
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISG20L2 

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ISG20L2 (see all 13):
    hsa-miR-3910 hsa-miR-34b* hsa-miR-324-3p hsa-miR-513a-3p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidISG20L2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20L2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ISG20L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for ISG20L2 (Q9H9L31, 2, 3 ENSP000003234244) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EML1O004231, 2, 3, ENSP000003343144EBI-751335,EBI-751327 MINT-68093 I2D: score=5 STRING: ENSP00000334314
    NCK1P163331, 3, ENSP000002889864EBI-751335,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042254ribosome biogenesis IEA--

    ISG20L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ISG20L2 (I20L2)

    Search CenterWatch for drugs/clinical trials and news about ISG20L2 / I20L2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ISG20L2 gene: 
    NM_030980.1  

    Unigene Cluster for ISG20L2:

    Interferon stimulated exonuclease gene 20kDa-like 2
    Hs.301904  [show with all ESTs]
    Unigene Representative Sequence: AL096734
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313146(uc001fps.1 uc001fpt.1) ENST00000472824 ENST00000368219
    ENST00000496538 ENST00000470713 ENST00000469074
    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate ISG20L2 (see all 13):
    hsa-miR-3910 hsa-miR-34b* hsa-miR-324-3p hsa-miR-513a-3p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidISG20L2 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISG20L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISG20L2

    Additional mRNA sequence: 

    AK021901.1 AK022733.1 AK095697.1 AK311586.1 AL096734.1 AY391837.1 BC000575.2 

    16 DOTS entries:

    DT.97847211  DT.100813740  DT.100779599  DT.101974286  DT.121643736  DT.97847213  DT.99953208  DT.110118 
    DT.100813742  DT.121428462  DT.100649415  DT.100813741  DT.40117599  DT.40128980  DT.97839696  DT.97847212 

    24/192 AceView cDNA sequences (see all 192):

    BC000575 BU508955 BX438918 CB045509 BU167919 AY391837 AA306294 BU535537 
    BM468132 AK095697 BU166743 AW511232 AA243098 BM455190 BU189704 BM542547 
    BM561694 BG285150 BU194754 BM460070 BU182803 BU171740 BQ440772 BM800151 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ISG20L2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                          -                       -                     
    SP2:                    -                                                   
    SP3:                    -     -                                             
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for ISG20L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ISG20L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAATTCCC
    ISG20L2 Expression
    About this image


    See ISG20L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ISG20L2

    SOURCE GeneReport for Unigene cluster: Hs.301904
        SABiosciences Custom PCR Arrays for ISG20L2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ISG20L2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isg20l21 , 5 interferon stimulated exonuclease gene 20-like 21, 5 79.81(n)1
    76.29(a)1
      3 (38.78 cM)5
    2295041  NM_177663.41  NP_808331.11 
     879303145 
    chicken
    (Gallus gallus)
    Aves ISG20L21 interferon stimulated exonuclease gene 20kDa-like 2 58.31(n)
    55.25(a)
      768992  XM_001232172.2  XP_001232173.2 
    lizard
    (Anolis carolinensis)
    Reptilia ISG20L26
    Uncharacterized protein
    42(a)
    1 ↔ 1
    GL343640.1(245101-249189)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003324691 interferon-stimulated 20 kDa exonuclease-like 2-like 50.51(n)
    46.42(a)
      100332469  XM_002664925.1  XP_002664971.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68336
    --
    27(a)
    1 → many
    3L(14044306-14045569)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX46
    Putative RNA exonuclease possibly involved in pre-...
    31(a)
    1 → many
    XV(180558-181427)


    ENSEMBL Gene Tree for ISG20L2 (if available)
    TreeFam Gene Tree for ISG20L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ISG20L2 gene
    ISG202  REXO42  AEN2  
    4 SIMAP similar genes for ISG20L2 using alignment to 1 protein entry:     I20L2_HUMAN:
    pp12744    ISG20    AEN    REXO4

    ISG20L2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ISG20L2
    PGOHUM00000242492 PGOHUM00000243504


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/172 SNPs in ISG20L2 are shown (see all 172)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120650431,2
    C,F--163190669(+) CGATGG/CCTGCT 1 -- ds50012Minor allele frequency- C:0.04CSA WA 120
    rs1395531371,2
    C--163190809(+) GTCTCA/GCTCTG 1 -- ds50010--------
    rs1886156781,2
    --163190870(+) GCTCCA/GCCTCC 1 -- ds50010--------
    rs1452653881,2
    --163190994(+) TAGCCA/GGGATG 1 -- ds50010--------
    rs46189601,2
    C--163191031(+) gcccgC/Tctcgg 1 -- ds5001 ese37Minor allele frequency- T:0.00NA WA CSA 13
    rs1449914521,2
    --163191078(+) ACGCCC/TGGCAG 1 -- ds50010--------
    rs1837391731,2
    C--163191079(+) CGCCCA/GGCAGG 1 -- ds50010--------
    rs45938151,2
    C,H--163191403(+) acaggC/Tgtgag 1 -- ut31 ese312Minor allele frequency- T:0.02NA CSA WA EA 376
    rs1486976981,2
    --163191549(+) TATGCC/TCTGCC 1 -- ut310--------
    rs1422052571,2
    C--163191699(+) ACACAA/GCACCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ISG20L2 (156691683 - 156698591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ISG20L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831648CNV Loss17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611930    OMIM disorders: --

    3 diseases for ISG20L2:    About MalaCards
    yellow fever    hepatitis a    hepatitis


    ISG20L2 for disorders           About GeneDecksing


    Export disorders for ISG20L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ISG20L2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ISG20L2)
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    1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. (PubMed id 18065403)1, 2, 3 Coute Y....Diaz J.J. (2008)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81875 HGNC: 25745 AceView: FLJ12671 Ensembl:ENSG00000143319 euGenes: HUgn81875
    ECgene: ISG20L2 H-InvDB: ISG20L2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ISG20L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ISG20L2 gene:
    Search GeneIP for patents involving ISG20L2

    GeneCards and IP:
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