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ISG20L2 Gene

protein-coding   GIFtS: 50
GCID: GC01M156691

Interferon Stimulated Exonuclease Gene 20kDa-Like 2

  Search for ISG20L2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Stimulated Exonuclease Gene 20kDa-Like 21 2
Interferon-Stimulated 20 KDa Exonuclease-Like 22
EC 3.1.-.-3

External Ids:    HGNC: 257451   Entrez Gene: 818752   Ensembl: ENSG000001433197   OMIM: 6119305   UniProtKB: Q9H9L33   

Export aliases for ISG20L2 gene to outside databases

Previous GC identifers: GC01M153506 GC01M154959 GC01M128049


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ISG20L2 Gene:
ISG20L2 (interferon stimulated exonuclease gene 20kDa-like 2) is a protein-coding gene. GO annotations related to this gene include exonuclease activity and nucleic acid binding. An important paralog of this gene is ISG20.

UniProtKB/Swiss-Prot: I20L2_HUMAN, Q9H9L3
Function: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays
a strong specificity for a 3'-end containing a free hydroxyl group




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISG20L2 gene promoter:
         E2F-3a   E2F-4   STAT1   E2F-5   E2F-2   STAT1alpha   E2F   E2F-1   Ik-2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISG20L2 promoter sequence
   Search Chromatin IP Primers for ISG20L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISG20L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q23.1

ISG20L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISG20L2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156691:  view genomic region     (about GC identifiers)

Start:
156,691,683 bp from pter      End:
156,698,591 bp from pter
Size:
6,909 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: I20L2_HUMAN, Q9H9L3 (See protein sequence)
Recommended Name: Interferon-stimulated 20 kDa exonuclease-like 2  
Size: 353 amino acids; 39154 Da
Secondary accessions: D3DVC6 Q64KA2

Explore the universe of human proteins at neXtProt for ISG20L2: NX_Q9H9L3

Explore proteomics data for ISG20L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ISG20L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112242.1  
    ENSEMBL proteins: 
     ENSP00000323424   ENSP00000357202  

    ISG20L2 Human Recombinant Protein Products:

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    Novus Biologicals ISG20L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISG20L2

     
    Search eBioscience for Proteins for ISG20L2 

    ISG20L2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for ISG20L2

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    Search eBioscience for ELISAs for ISG20L2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H9L3

    ProtoNet protein and cluster: Q9H9L3

    1 Blocks protein domain: IPB006055 Exonuclease

    UniProtKB/Swiss-Prot: I20L2_HUMAN, Q9H9L3
    Similarity: Contains 1 exonuclease domain


    Find genes that share domains with ISG20L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: I20L2_HUMAN, Q9H9L3
    Function: 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays
    a strong specificity for a 3'-end containing a free hydroxyl group

         Enzyme Number (IUBMB): EC 3.1.-.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004527exonuclease activity IEA--
    GO:0005515protein binding IPI16189514
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ISG20L2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ISG20L2:
     Decreased TP53 protein express  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISG20L2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ISG20L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISG20L2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISG20L2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ISG20L2:
    hsa-mir-877-3p (MIRT036818), hsa-mir-222-3p (MIRT046613)

    Block miRNA regulation of human, mouse, rat ISG20L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISG20L2 (see all 13):
    hsa-miR-3910 hsa-miR-34b* hsa-miR-324-3p hsa-miR-513a-3p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidISG20L2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ISG20L2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ISG20L2 (NM_030980)
    Sino Biological Human cDNA Clone for ISG20L2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISG20L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISG20L2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for ISG20L2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20L2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    I20L2_HUMAN, Q9H9L3: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005730nucleolus IEA--
    GO:0043231intracellular membrane-bounded organelle ----

    Find genes that share ontologies with ISG20L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISG20L2
    Interactions:

        Search GeneGlobe Interaction Network for ISG20L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ISG20L2 (Q9H9L31, 2, 3 ENSP000003234244) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EML1O004231, 2, 3, ENSP000003343144EBI-751335,EBI-751327 MINT-68093 I2D: score=5 STRING: ENSP00000334314
    NCK1P163331, 3, ENSP000002889864EBI-751335,EBI-389883 I2D: score=1 STRING: ENSP00000288986
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    PLCG1P191743, ENSP000002440074I2D: score=1 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042254ribosome biogenesis IEA--

    Find genes that share ontologies with ISG20L2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISG20L2 (I20L2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ISG20L2 gene: 
    NM_030980.1  

    Unigene Cluster for ISG20L2:

    Interferon stimulated exonuclease gene 20kDa-like 2
    Hs.301904  [show with all ESTs]
    Unigene Representative Sequence: AL096734
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472824 ENST00000313146(uc001fps.1 uc001fpt.1) ENST00000368219
    ENST00000496538 ENST00000470713 ENST00000469074
    miRNA
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    Block miRNA regulation of human, mouse, rat ISG20L2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ISG20L2 (see all 13):
    hsa-miR-3910 hsa-miR-34b* hsa-miR-324-3p hsa-miR-513a-3p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidISG20L2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ISG20L2
    Predesigned siRNA for gene silencing in human, mouse, rat ISG20L2
    Clone
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    OriGene clones in human, mouse for ISG20L2 (see all 7)
    OriGene ORF clones in mouse, rat for ISG20L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ISG20L2 (NM_030980)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISG20L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISG20L2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ISG20L2
    OriGene qSTAR qPCR primer pairs in human, mouse for ISG20L2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISG20L2
      QuantiTect SYBR Green Assays in human, mouse, rat ISG20L2
      QuantiFast Probe-based Assays in human, mouse, rat ISG20L2

    Additional mRNA sequence: 

    AK021901.1 AK022733.1 AK095697.1 AK311586.1 AL096734.1 AY391837.1 BC000575.2 

    16 DOTS entries:

    DT.97847211  DT.100813740  DT.100779599  DT.101974286  DT.121643736  DT.97847213  DT.99953208  DT.110118 
    DT.100813742  DT.121428462  DT.100649415  DT.100813741  DT.40117599  DT.40128980  DT.97839696  DT.97847212 

    Selected AceView cDNA sequences (see all 192):

    BX438918 AY391837 BU189704 BG285150 BU508955 BC000575 BU194754 BM460070 
    BM455190 BU167919 BQ440772 AA243098 AW511232 BM561694 BM468132 BU535537 
    BM800151 BU166743 AA306294 BU182803 CB045509 AK095697 BM542547 BU171740 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ISG20L2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                          -                       -                     
    SP2:                    -                                                   
    SP3:                    -     -                                             
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for ISG20L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ISG20L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAATTCCC
    ISG20L2 Expression
    About this image

    ISG20L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISG20L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301904
        Custom PCR Arrays for ISG20L2
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    QuantiFast Probe-based Assays in human, mouse, rat ISG20L2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ISG20L2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isg20l21 , 5 interferon stimulated exonuclease gene 20-like 21, 5 78.5(n)1
    74.72(a)1
      3 (38.78 cM)5
    2295041  NM_177663.41  NP_808331.11 
     879303145 
    lizard
    (Anolis carolinensis)
    Reptilia ISG20L26
    interferon stimulated exonuclease gene 20kDa-like ...
    45(a)
    1 ↔ 1
    GL343640.1(245101-249189)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia isg20l21 interferon stimulated exonuclease gene 20kDa-like 2 55.93(n)
    52.58(a)
      448477  NM_001004997.1  NP_001004997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii isg20l26
    interferon stimulated exonuclease gene 20-like 2
    42(a)
    1 ↔ 1
    16(31590554-31636277) ENSDARG00000077968
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX46
    Putative RNA exonuclease possibly involved in pre-...
    33(a)
    1 → many
    XV(180558-181427) YOL080C


    ENSEMBL Gene Tree for ISG20L2 (if available)
    TreeFam Gene Tree for ISG20L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ISG20L2 gene
    ISG202  REXO42  AEN2  
    4 SIMAP similar genes for ISG20L2 using alignment to 1 protein entry:     I20L2_HUMAN:
    pp12744    ISG20    AEN    REXO4

    Find genes that share paralogs with ISG20L2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for ISG20L2
    PGOHUM00000242492 PGOHUM00000243504


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ISG20L2 (see all 172)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1120650431,2
    C,F--163190669(+) CGATGG/CCTGCT 1 -- ds50012Minor allele frequency- C:0.04CSA WA 120
    rs1395531371,2
    C--163190809(+) GTCTCA/GCTCTG 1 -- ds50010--------
    rs1886156781,2
    --163190870(+) GCTCCA/GCCTCC 1 -- ds50010--------
    rs1452653881,2
    --163190994(+) TAGCCA/GGGATG 1 -- ds50010--------
    rs46189601,2
    C--163191031(+) gcccgC/Tctcgg 1 -- ds5001 ese37Minor allele frequency- T:0.00NA WA CSA 13
    rs1449914521,2
    --163191078(+) ACGCCC/TGGCAG 1 -- ds50010--------
    rs1837391731,2
    C--163191079(+) CGCCCA/GGCAGG 1 -- ds50010--------
    rs45938151,2
    C,H--163191403(+) acaggC/Tgtgag 1 -- ut31 ese312Minor allele frequency- T:0.02NA CSA WA EA 376
    rs1486976981,2
    --163191549(+) TATGCC/TCTGCC 1 -- ut310--------
    rs1422052571,2
    C--163191699(+) ACACAA/GCACCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ISG20L2 (156691683 - 156698591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ISG20L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831648CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISG20L2
    DNA2.0 Custom Variant and Variant Library Synthesis for ISG20L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611930    OMIM disorders: --


    Find genes that share disorders with ISG20L2           About GenesLikeMe


    Export disorders for ISG20L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISG20L2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with ISG20L2)
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    1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. (PubMed id 18065403)1, 2, 3 Coute Y.... Diaz J.-J. (Mol. Cell. Proteomics 2008)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    8. Genome-scale RNAi screen for host factors required for HIV replication. (PubMed id 18976975)1 Zhou H....Espeseth A.S. (amp 2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (Proteomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81875 HGNC: 25745 AceView: FLJ12671 Ensembl:ENSG00000143319 euGenes: HUgn81875
    ECgene: ISG20L2 H-InvDB: ISG20L2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ISG20L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISG20L2 gene:
    Search GeneIP for patents involving ISG20L2

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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