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Aliases for ISG20L2 Gene

Aliases for ISG20L2 Gene

  • Interferon Stimulated Exonuclease Gene 20kDa Like 2 2 3 5
  • Interferon Stimulated Exonuclease Gene 20kDa-Like 2 2 3
  • EC 3.1.-.- 4
  • HSD38 3

External Ids for ISG20L2 Gene

Previous GeneCards Identifiers for ISG20L2 Gene

  • GC01M153506
  • GC01M154959
  • GC01M156691
  • GC01M128049

Summaries for ISG20L2 Gene

Entrez Gene Summary for ISG20L2 Gene

  • This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]

GeneCards Summary for ISG20L2 Gene

ISG20L2 (Interferon Stimulated Exonuclease Gene 20kDa Like 2) is a Protein Coding gene. Among its related pathways are Gene Expression and rRNA processing. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ISG20.

UniProtKB/Swiss-Prot for ISG20L2 Gene

  • 3-> 5-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3-end containing a free hydroxyl group.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISG20L2 Gene

Genomics for ISG20L2 Gene

Regulatory Elements for ISG20L2 Gene

Promoters for ISG20L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ISG20L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ISG20L2 Gene

Chromosome:
1
Start:
156,721,891 bp from pter
End:
156,728,799 bp from pter
Size:
6,909 bases
Orientation:
Minus strand

Genomic View for ISG20L2 Gene

Genes around ISG20L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISG20L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISG20L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISG20L2 Gene

Proteins for ISG20L2 Gene

  • Protein details for ISG20L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9L3-I20L2_HUMAN
    Recommended name:
    Interferon-stimulated 20 kDa exonuclease-like 2
    Protein Accession:
    Q9H9L3
    Secondary Accessions:
    • D3DVC6
    • Q64KA2

    Protein attributes for ISG20L2 Gene

    Size:
    353 amino acids
    Molecular mass:
    39154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISG20L2 Gene

Proteomics data for ISG20L2 Gene at MOPED

Post-translational modifications for ISG20L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISG20L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ISG20L2 Gene

Domains & Families for ISG20L2 Gene

Gene Families for ISG20L2 Gene

Protein Domains for ISG20L2 Gene

Suggested Antigen Peptide Sequences for ISG20L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9L3

UniProtKB/Swiss-Prot:

I20L2_HUMAN :
  • Contains 1 exonuclease domain.
Domain:
  • Contains 1 exonuclease domain.
genes like me logo Genes that share domains with ISG20L2: view

Function for ISG20L2 Gene

Molecular function for ISG20L2 Gene

UniProtKB/Swiss-Prot Function:
3-> 5-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3-end containing a free hydroxyl group.

Enzyme Numbers (IUBMB) for ISG20L2 Gene

Gene Ontology (GO) - Molecular Function for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004527 exonuclease activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ISG20L2: view
genes like me logo Genes that share phenotypes with ISG20L2: view

Animal Model Products

CRISPR Products

miRNA for ISG20L2 Gene

miRTarBase miRNAs that target ISG20L2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISG20L2 Gene

Localization for ISG20L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG20L2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISG20L2 Gene COMPARTMENTS Subcellular localization image for ISG20L2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ISG20L2 Gene

Pathways & Interactions for ISG20L2 Gene

genes like me logo Genes that share pathways with ISG20L2: view

Pathways by source for ISG20L2 Gene

Gene Ontology (GO) - Biological Process for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

No data available for SIGNOR curated interactions for ISG20L2 Gene

Drugs & Compounds for ISG20L2 Gene

No Compound Related Data Available

Transcripts for ISG20L2 Gene

Unigene Clusters for ISG20L2 Gene

Interferon stimulated exonuclease gene 20kDa-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISG20L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for ISG20L2 Gene

GeneLoc Exon Structure for
ISG20L2
ECgene alternative splicing isoforms for
ISG20L2

Expression for ISG20L2 Gene

mRNA expression in normal human tissues for ISG20L2 Gene

mRNA differential expression in normal tissues according to GTEx for ISG20L2 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for ISG20L2 Gene

This gene is overexpressed in Lung (22.4), Peripheral blood mononuclear cells (16.2), CD8 Tcells (8.8), Pancreas (8.0), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISG20L2 Gene



SOURCE GeneReport for Unigene cluster for ISG20L2 Gene Hs.301904

genes like me logo Genes that share expression patterns with ISG20L2: view

Protein tissue co-expression partners for ISG20L2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ISG20L2 Gene

Orthologs for ISG20L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISG20L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ISG20L2 35
  • 88.7 (n)
  • 88.51 (a)
ISG20L2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ISG20L2 35
  • 87.26 (n)
  • 87.93 (a)
ISG20L2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Isg20l2 35
  • 78.5 (n)
  • 74.72 (a)
Isg20l2 16
Isg20l2 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ISG20L2 35
  • 98.01 (n)
  • 98.58 (a)
ISG20L2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Isg20l2 35
  • 79.26 (n)
  • 75.85 (a)
oppossum
(Monodelphis domestica)
Mammalia ISG20L2 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ISG20L2 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ISG20L2 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia isg20l2 35
  • 55.93 (n)
  • 52.58 (a)
zebrafish
(Danio rerio)
Actinopterygii isg20l2 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for ISG20L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISG20L2 Gene

ENSEMBL:
Gene Tree for ISG20L2 (if available)
TreeFam:
Gene Tree for ISG20L2 (if available)

Paralogs for ISG20L2 Gene

Paralogs for ISG20L2 Gene

(4) SIMAP similar genes for ISG20L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ISG20L2 Gene

genes like me logo Genes that share paralogs with ISG20L2: view

Variants for ISG20L2 Gene

Sequence variations from dbSNP and Humsavar for ISG20L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_038171 -
rs1133856 -- 156,723,343(-) TGGCA(A/C/G)TGGGG utr-variant-3-prime
rs4618960 -- 156,722,514(+) gcccg(C/T)ctcgg utr-variant-3-prime
rs4593815 -- 156,722,886(+) acagg(C/T)gtgag downstream-variant-500B, utr-variant-3-prime
rs12023776 -- 156,725,745(+) TTGCT(A/G)TCTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ISG20L2 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV Loss 17160897

Variation tolerance for ISG20L2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISG20L2 Gene

HapMap Linkage Disequilibrium report
ISG20L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG20L2 Gene

Disorders for ISG20L2 Gene

Relevant External Links for ISG20L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISG20L2

No disorders were found for ISG20L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISG20L2 Gene

Publications for ISG20L2 Gene

  1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. (PMID: 18065403) Coute Y. … Diaz J.-J. (Mol. Cell. Proteomics 2008) 2 3 4 67
  2. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3
  3. Proteomic characterization of the human FTSJ3 preribosomal complexes. (PMID: 22540864) Simabuco F.M. … Zanchin N.I. (J. Proteome Res. 2012) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Antiviral activities of ISG20 in positive-strand RNA virus infections. (PMID: 21036379) Zhou Z. … Li K. (Virology 2011) 3

Products for ISG20L2 Gene

Sources for ISG20L2 Gene

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