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Aliases for ISG20L2 Gene

Aliases for ISG20L2 Gene

  • Interferon Stimulated Exonuclease Gene 20 Like 2 2 3 5
  • Interferon Stimulated Exonuclease Gene 20kDa-Like 2 2
  • Interferon Stimulated Exonuclease Gene 20kDa Like 2 3
  • Interferon-Stimulated 20 KDa Exonuclease-Like 2 3
  • EC 3.1.-.- 4
  • HSD38 3

External Ids for ISG20L2 Gene

Previous GeneCards Identifiers for ISG20L2 Gene

  • GC01M153506
  • GC01M154959
  • GC01M156691
  • GC01M128049

Summaries for ISG20L2 Gene

Entrez Gene Summary for ISG20L2 Gene

  • This gene encodes a 3'-5' exoribonuclease that may be involved in the processing of the 12S pre-rRNA. Pseudogenes have been identified on chromosomes 6 and 11. [provided by RefSeq, Dec 2014]

GeneCards Summary for ISG20L2 Gene

ISG20L2 (Interferon Stimulated Exonuclease Gene 20 Like 2) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is AEN.

UniProtKB/Swiss-Prot for ISG20L2 Gene

  • 3-> 5-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3-end containing a free hydroxyl group.

Additional gene information for ISG20L2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISG20L2 Gene

Genomics for ISG20L2 Gene

Regulatory Elements for ISG20L2 Gene

Enhancers for ISG20L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H156111 1.8 FANTOM5 ENCODE dbSUPER 36.9 +607.4 607410 19 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 GON4L CLK2 RRNAD1 KIAA0907 LOC246784 LMNA MSTO1 MSTO2P PRCC ISG20L2
GH01H156656 2.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 24.4 +64.5 64541 15 MLX ZFP64 DMAP1 ZNF416 ZNF143 SP3 MCM3 ZC3H11A SSRP1 ZNF610 GON4L KIAA0907 LOC246784 RRNAD1 PRCC MSTO2P LMNA ISG20L2 YY1AP1 TSACC
GH01H156486 2.1 FANTOM5 Ensembl ENCODE dbSUPER 27.1 +229.9 229936 25 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF610 GLIS1 RRNAD1 GON4L KIAA0907 ENSG00000271267 MSTO2P MSTO1 LOC246784 ISG20L2 ENSG00000246203 MEF2D
GH01H155930 1.4 ENCODE dbSUPER 39.9 +795.9 795909 5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 GON4L RRNAD1 KIAA0907 ISG20L2 LOC101928120 CCT3 MSTO2P MSTO1 THBS3 CLK2
GH01H156765 1.7 Ensembl ENCODE dbSUPER 25.7 -39.1 -39147 4 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 RRNAD1 GON4L KIAA0907 LOC246784 ISG20L2 CCT3 MRPL24 LRRC71 ENSG00000229961 ENSG00000233712
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ISG20L2 on UCSC Golden Path with GeneCards custom track

Promoters for ISG20L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014244 99 1801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143

Genomic Location for ISG20L2 Gene

Chromosome:
1
Start:
156,721,891 bp from pter
End:
156,728,799 bp from pter
Size:
6,909 bases
Orientation:
Minus strand

Genomic View for ISG20L2 Gene

Genes around ISG20L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISG20L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISG20L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISG20L2 Gene

Proteins for ISG20L2 Gene

  • Protein details for ISG20L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9L3-I20L2_HUMAN
    Recommended name:
    Interferon-stimulated 20 kDa exonuclease-like 2
    Protein Accession:
    Q9H9L3
    Secondary Accessions:
    • D3DVC6
    • Q64KA2

    Protein attributes for ISG20L2 Gene

    Size:
    353 amino acids
    Molecular mass:
    39154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ISG20L2 Gene

Post-translational modifications for ISG20L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISG20L2 Gene

No data available for DME Specific Peptides for ISG20L2 Gene

Domains & Families for ISG20L2 Gene

Gene Families for ISG20L2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ISG20L2 Gene

Suggested Antigen Peptide Sequences for ISG20L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ISG20L2: view

No data available for UniProtKB/Swiss-Prot for ISG20L2 Gene

Function for ISG20L2 Gene

Molecular function for ISG20L2 Gene

UniProtKB/Swiss-Prot Function:
3-> 5-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3-end containing a free hydroxyl group.

Enzyme Numbers (IUBMB) for ISG20L2 Gene

Phenotypes From GWAS Catalog for ISG20L2 Gene

Gene Ontology (GO) - Molecular Function for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000175 3-5-exoribonuclease activity EXP 18065403
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0004518 nuclease activity IEA --
GO:0004527 exonuclease activity IEA --
genes like me logo Genes that share ontologies with ISG20L2: view
genes like me logo Genes that share phenotypes with ISG20L2: view

Animal Model Products

CRISPR Products

miRNA for ISG20L2 Gene

miRTarBase miRNAs that target ISG20L2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ISG20L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISG20L2 Gene

Localization for ISG20L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG20L2 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ISG20L2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

Pathways & Interactions for ISG20L2 Gene

genes like me logo Genes that share pathways with ISG20L2: view

Gene Ontology (GO) - Biological Process for ISG20L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0042254 ribosome biogenesis IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IEA --
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic IEA --
genes like me logo Genes that share ontologies with ISG20L2: view

No data available for SIGNOR curated interactions for ISG20L2 Gene

Drugs & Compounds for ISG20L2 Gene

No Compound Related Data Available

Transcripts for ISG20L2 Gene

Unigene Clusters for ISG20L2 Gene

Interferon stimulated exonuclease gene 20kDa-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ISG20L2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ISG20L2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for ISG20L2 Gene

GeneLoc Exon Structure for
ISG20L2
ECgene alternative splicing isoforms for
ISG20L2

Expression for ISG20L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ISG20L2 Gene

mRNA differential expression in normal tissues according to GTEx for ISG20L2 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for ISG20L2 Gene

This gene is overexpressed in Lung (22.4), Peripheral blood mononuclear cells (16.2), CD8 Tcells (8.8), Pancreas (8.0), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ISG20L2 Gene



Protein tissue co-expression partners for ISG20L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ISG20L2 Gene:

ISG20L2

SOURCE GeneReport for Unigene cluster for ISG20L2 Gene:

Hs.301904

Evidence on tissue expression from TISSUES for ISG20L2 Gene

  • Heart(5)
  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ISG20L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ISG20L2 Gene

Orthologs for ISG20L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISG20L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISG20L2 33 34
  • 98.01 (n)
cow
(Bos Taurus)
Mammalia ISG20L2 33 34
  • 88.7 (n)
dog
(Canis familiaris)
Mammalia ISG20L2 33 34
  • 87.26 (n)
rat
(Rattus norvegicus)
Mammalia Isg20l2 33
  • 79.26 (n)
mouse
(Mus musculus)
Mammalia Isg20l2 33 16 34
  • 78.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ISG20L2 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ISG20L2 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ISG20L2 34
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia isg20l2 33
  • 55.93 (n)
zebrafish
(Danio rerio)
Actinopterygii isg20l2 34
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 34
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for ISG20L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ISG20L2 Gene

ENSEMBL:
Gene Tree for ISG20L2 (if available)
TreeFam:
Gene Tree for ISG20L2 (if available)

Paralogs for ISG20L2 Gene

Paralogs for ISG20L2 Gene

(4) SIMAP similar genes for ISG20L2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ISG20L2 Gene

genes like me logo Genes that share paralogs with ISG20L2: view

Variants for ISG20L2 Gene

Sequence variations from dbSNP and Humsavar for ISG20L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000505087 -- 156,722,859(+) GCCTC(A/G)GCCTC utr-variant-3-prime
rs1001183087 -- 156,729,224(+) AGGCC(A/G)CAGGG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001219091 -- 156,722,529(+) CCAAA(A/G)TGCTG utr-variant-3-prime
rs1001537087 -- 156,729,292(+) ATCTG(G/T)AGAAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001609278 -- 156,729,531(+) CTACC(C/T)AGATT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ISG20L2 Gene

Variant ID Type Subtype PubMed ID
nsv831648 CNV loss 17160897

Variation tolerance for ISG20L2 Gene

Residual Variation Intolerance Score: 45.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISG20L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ISG20L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG20L2 Gene

Disorders for ISG20L2 Gene

Relevant External Links for ISG20L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISG20L2

No disorders were found for ISG20L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ISG20L2 Gene

Publications for ISG20L2 Gene

  1. ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis. (PMID: 18065403) Couté Y … Diaz JJ (Molecular & cellular proteomics : MCP 2008) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A … Diaz JJ (Molecular biology of the cell 2002) 3 4 60

Products for ISG20L2 Gene

Sources for ISG20L2 Gene

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