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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ISG20 Gene

protein-coding GIFtS: 60
GCID: GC15P089181

interferon stimulated exonuclease gene 20kDa

(Previous name: interferon stimulated gene (20kD) )

Explore 45 diseases affiliated with
ISG20 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Interferon Stimulated Exonuclease Gene 20kDa¹ ²		Promyelocytic Leukemia Nuclear Body-Associated Protein ISG20² ³
HEM45¹ ² ³ ⁵		EC 3.1.13.1³ ⁸
CD25¹ ²		Interferon Stimulated Gene (20kD)¹
Estrogen-Regulated Transcript 45 Protein² ³		Interferon-Stimulated Gene 20 KDa Protein²

External Ids:	HGNC: 6130¹	Entrez Gene: 3669²	Ensembl: ENSG00000172183⁷	OMIM: 604533⁵	UniProtKB: Q96AZ6³

Export aliases for ISG20 gene to outside databases

Previous GC identifers: GC15P085474 GC15P082547 GC15P086766 GC15P086911 GC15P086983 GC15P065293

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6

Function: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate

that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN

against RNA viruses

Function: Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs and

rRNAs, and in ribosome biogenesis

Gene Wiki entry for ISG20

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ISG20 gene promoter:
AREB6 STAT1 Tal-1 Hand1 En-1 E47 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ISG20 promoter sequence

Search SABiosciences Chromatin IP Primers for ISG20

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISG20

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26

ISG20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISG20 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P089181: view genomic region (about GC identifiers)

Start:	89,179,384 bp from pter	End:	89,199,714 bp from pter
Size:	20,331 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6 (See protein sequence)

Recommended Name: Interferon-stimulated gene 20 kDa protein

Size: 181 amino acids; 20363 Da

Cofactor: Binds 2 manganese ions per subunit

Subunit: Associates with PML and SP100 in the PML NB complex

Subcellular location: Nucleus

Miscellaneous: Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV), influenza

virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative antiviral pathway

against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer lines

1 PDB 3D structure from and Proteopedia for ISG20:

1WLJ (3D)

Secondary accessions: O00441 O00586

Alternative splicing: 2 isoforms: Q96AZ6-1 Q96AZ6-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ISG20: NX_Q96AZ6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96AZ6

2 DME Specific Peptides for ISG20 (Q96AZ6)

HSSVEDA

VGHDLKHD

ISG20 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002192.2

ENSEMBL proteins:

ENSP00000453638 ENSP00000306565 ENSP00000368526 ENSP00000453666

Reactome Protein details: Q96AZ6
Human Recombinant Protein Products:

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	Novus Biologicals ISG20 Protein Novus Biologicals ISG20 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ISG20

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005654	nucleoplasm	TAS	--
GO:0016605	PML body	IDA	9235947

ISG20 for ontologies About GeneDecksing

ISG20 Antibody Products:

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	Uscn ELISAs and CLIAs for ISG20

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ISG20 for domains About GeneDecksing

3 InterPro domains/families:

IPR013520 Exonuclease_RNaseT/DNA_pol3

IPR006055 Exonuclease

IPR012337 RNaseH-like_dom

Graphical View of Domain Structure for InterPro Entry Q96AZ6

ProtoNet protein and cluster: Q96AZ6

2 Blocks protein families:

IPB006055 Exonuclease

IPB013520 Exonuclease

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6

Similarity: Belongs to the exonuclease superfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6

Function: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate

that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral function of IFN

against RNA viruses

Function: Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs and

rRNAs, and in ribosome biogenesis

Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

Biophysicochemical properties: pH dependence: Optimum pH is 7.0;

Induction: Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression

was seen at the transcriptional level

Genatlas biochemistry entry for ISG20:

interferon stimulated PML nuclear body associated protein 20kDa,Xenopus XPMC2 homolog

Enzyme Number (IUBMB): EC 3.1.13.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone: ISG20 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISG20
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISG20 (see all 7) OriGene shRNA RFP: ISG20 OriGene siRNA: ISG20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISG20

Gene Editing
Products:

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ISG20
		Search LifeMap BioReagents cell lines for ISG20

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000175	3'-5'-exoribonuclease activity	IDA	11401564
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--
GO:0004527	exonuclease activity	--	--
GO:0008310	single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	IDA	11401564

ISG20 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ISG20:

Increased number of cells in m

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Expression of IFN-induced genes

Expression of IFN-induced genes

1.00

Interferon alpha/beta signaling

0.61

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for ISG20

	Interferon alpha/beta signaling
	Cytokine Signaling in Immune system
	Expression of IFN-induced genes
	Interferon Signaling
	Immune System

ISG20 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ISG20

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/45 Interacting proteins for ISG20 (Q96AZ6³ ENSP00000306565⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IRF1	P10914³, ENSP00000245414⁴	I2D: score=1 STRING: ENSP00000245414
NFKB1	P19838³	I2D: score=1
RELA	Q04206³	I2D: score=1
ADAR	ENSP00000357459⁴	STRING: ENSP00000357459
EGR1	ENSP00000239938⁴	STRING: ENSP00000239938

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000738	DNA catabolic process, exonucleolytic	IDA	11401564
GO:0006364	rRNA processing	IEA	--
GO:0006401	RNA catabolic process	IDA	11401564
GO:0008283	cell proliferation	TAS	9569007
GO:0009615	response to virus	IDA	12594219

ISG20 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ISG20 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ISG20

1 HMDB Compound for ISG20 About this table

Compound	Synonyms	CAS #	PubMed Ids
Manganese	manganese	7439-96-5	--

1 DrugBank Compound for ISG20 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Uridine-5'-Monophosphate	--	58-97-9	target	--	17139284 17016423

8 Novoseek chemical compound relationships for ISG20 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-oligoadenylate	69.1	2	20046508 (1), 17669408 (1)
5-methylthioadenosine	67	4	7825061 (1), 1385305 (1), 8689637 (1), 8689636 (1)
2-methoxyestradiol	45.8	6	11856647 (2), 17014383 (2)
ribavirin	29.6	2	10581390 (1), 18713278 (1)
adenine	4.74	1	2219731 (1)
oligonucleotide	3.45	1	18352910 (1)
tyrosine	0	1	8537333 (1)
estrogen	0	1	11401564 (1)

Search CenterWatch for drugs/clinical trials and news about ISG20

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ISG20 gene:

NM_002201.4

Unigene Cluster for ISG20:

Interferon stimulated exonuclease gene 20kDa

Hs.459265 [show with all ESTs]

Unigene Representative Sequence: AB209639

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000560741 ENST00000558992 ENST00000306072(uc002bmv.1) ENST00000379224

ENST00000559876 ENST00000558942 ENST00000560573(uc002bmu.1 uc010upn.1)

ENST00000557824 ENST00000558236 ENST00000560746 ENST00000546338

miRNA Products:		OriGene 3'-UTR Clone: ISG20 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISG20
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ISG20
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ISG20 (see all 7) OriGene shRNA RFP: ISG20 OriGene siRNA: ISG20
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ISG20

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		GenScript: all cDNA clones in your preferred vector: ISG20 (NM_002201)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISG20
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISG20
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISG20

Additional cDNA sequence:

AB209639.1 AK122793.1 AK307769.1 BC007922.2 BC016341.1 BT006952.1 CR456942.1 U88964.1

X89773.2

11 DOTS entries:

DT.213778 DT.100641175 DT.95272298 DT.95313299 DT.100026436 DT.101975462 DT.100819030 DT.121014585

DT.75102836 DT.40118787 DT.95219058

24/142 AceView cDNA sequences (see all 142):

CB125863 CR625782 BG684223 BX490703 AA470680 AW009108 BE675647 CB126461

AW966891 BG684672 CB114498 CB126685 AI283917 CR619922 BG744069 BM754903

CB125783 CD672839 AJ714720 CB125224 CB114442 BV207406 BG035702 BI835038

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ISG20 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c
SP1:									-				-		-
SP2:									-				-		-		-
SP3:			-		-		-		-				-		-
SP4:									-
SP5:

ECgene alternative splicing isoforms for ISG20

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ISG20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCGGCTACA

About this image

ISG20 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Alveolar type II cells (Derivation of mature...)

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ISG20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ISG20

SOURCE GeneReport for Unigene cluster: Hs.459265

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6

Tissue specificity: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including ISG20:

Th17 Response in human mouse rat

Type I Interferon Response in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for ISG20 (if available)
TreeFam Gene Tree for ISG20 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ISG20 gene

ISG20L2² REXO4² AEN²

8 SIMAP similar genes for ISG20 using alignment to 3 protein entries: ISG20_HUMAN (see all proteins):

AEN ISG20L2 pp12744 LOC81691 REXO1 REXO1L10P

REXO1L1 REXO1L2P

ISG20 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66503151^1,2	C	--	89180564(+)	`TTTTT-/TT TTTTTGGACA`	1	--	us2k¹		2		NA	4
rs34579586^1,2	C,F,	--	89185852(+)	`ATTTT-/TTGTTGTT`	1	--	int¹		2		NA CSA	4
rs11856565^1,2	C,F,H	--	89187786(+)	`AAAGAA/CAAAAA`	1	--	int¹		3		NA	10
rs67738947^1,2	C,	--	89187786(+)	`AAAGA-/CAAAAA`	1	--	int¹		1		NA	2
rs201287111^1,2		--	89195583(+)	`CTCCCC/TCTCCT`	1	--	int¹		0	--	--	--	--
rs112584899^1,2		--	89195592(+)	`CTCCCG/CCTCCT`	1	--	int¹		1		CSA	1
rs192154913^1,2		--	89195612(+)	`TCTCCA/GTTTCC`	1	--	int¹		0	--	--	--	--
rs183573306^1,2		--	89195640(+)	`CTCCTC/TCCCCT`	1	--	int¹		0	--	--	--	--
rs188573761^1,2		--	89195702(+)	`TCCTCC/TCCCTC`	1	--	int¹		0	--	--	--	--
rs192797228^1,2		--	89195782(+)	`TGCCCA/TCCTCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ISG20 (89179384 - 89199714 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ISG20: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ISG20

DNA2.0 Custom Variant and Variant Library Synthesis for ISG20

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ISG20 for disorders           About GeneDecksing

OMIM gene information: 604533    OMIM disorders: --

20/45 diseases for ISG20 (see all 45):    About MalaCards

crimean-congo hemorrhagic fever estrogen-receptor positive breast cancer leukemia mast-cell leukemia

hemorrhagic fever myxoid chondrosarcoma herpes simplex lupus erythematosus

malignant glioma hepatitis c lymphoblastic leukemia squamous cell carcinoma of the head and neck

systemic lupus erythematosus squamous cell carcinoma cytomegalovirus infection chondrosarcoma

acute lymphoblastic leukemia kaposi's sarcoma hepatitis b mumps

10/23 Novoseek disease relationships for ISG20 gene (see all 23) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
virus infection	43.7	9	18352910 (2), 15064705 (1), 18338947 (1), 14668931 (1) (see all 6)
hepatitis c chronic	32.6	2	17302252 (1), 16731032 (1)
lymphoblastic leukemia acute	32	3	2294436 (1), 1886420 (1), 1694263 (1)
tumors	19.9	8	7825061 (1), 11687902 (1), 20140953 (1), 8462339 (1) (see all 7)
leukemia	19.6	1	8158846 (1)
melanoma	19.1	1	8687130 (1)
chondrosarcoma	17.9	1	8689637 (1)
hepatitis c	13	1	18338947 (1)
malignant glioma	11.6	2	1598130 (1), 1501894 (1)
lupus erythematosus systemic	8.01	2	15840221 (1), 19633559 (1)

Export disorders for ISG20 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ISG20 gene, integrated from 9 sources (see all 137):
(articles sorted by number of sources associating them with ISG20)

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Molecular cloning of a new interferon-inductible PML nuclear bodies- associated protein. (PubMed id 9235947)^{1, 2, 3, 9} Gongora C....Mechti N. (1997)
ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. (PubMed id 12594219)^{1, 2, 9} Espert L.... Mechti N. (2003)
The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. (PubMed id 11401564)^{1, 2, 9} Nguyen L.H.... Wilson D.M. III (2001)
Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease. (PubMed id 15527770)^{1, 2} Horio T....Ohgi T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus. (PubMed id 9569007)^{1, 2} Pentecost B.T. (1998)
Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization. (PubMed id 9605874)^{1, 3} Mattei M.G....Mechti N. (1997)
Vpu-deficient HIV strains stimulate innate immune sign aling responses in target cells. (PubMed id 22647704)¹ Doehle B.P....Gale M. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Antiviral activities of ISG20 in positive-strand RNA virus infections. (PubMed id 21036379)¹ Zhou Z....Li K. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3669	HGNC: 6130	AceView: ISG20	Ensembl:ENSG00000172183	euGenes: HUgn3669
ECgene: ISG20	H-InvDB: ISG20

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ISG20	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ISG20	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ISG20 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ISG20 gene:
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interferon stimulated exonuclease gene 20kDa

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interferon stimulated exonuclease gene 20kDa

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