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ISG20 Gene

protein-coding   GIFtS: 62
GCID: GC15P089181

Interferon Stimulated Exonuclease Gene 20kDa

(Previous name: interferon stimulated gene (20kD))
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Stimulated Exonuclease Gene 20kDa1 2     EC 3.1.13.13 8
HEM452 3 5     Interferon Stimulated Gene (20kD)1
Estrogen-Regulated Transcript 45 Protein2 3     CD252
Promyelocytic Leukemia Nuclear Body-Associated Protein ISG202 3     Interferon-Stimulated Gene 20 KDa Protein2

External Ids:    HGNC: 61301   Entrez Gene: 36692   Ensembl: ENSG000001721837   OMIM: 6045335   UniProtKB: Q96AZ63   

Export aliases for ISG20 gene to outside databases

Previous GC identifers: GC15P085474 GC15P082547 GC15P086766 GC15P086911 GC15P086983 GC15P065293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ISG20 Gene:
ISG20 (interferon stimulated exonuclease gene 20kDa) is a protein-coding gene. Diseases associated with ISG20 include mast-cell leukemia, and crimean-congo hemorrhagic fever. GO annotations related to this gene include single-stranded DNA 3'-5' exodeoxyribonuclease activity and exonuclease activity. An important paralog of this gene is REXO4.

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6
Function: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor
activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus
(HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play
additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis

Gene Wiki entry for ISG20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISG20 gene promoter:
         AREB6   STAT1   Tal-1   Hand1   En-1   E47   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ISG20 promoter sequence
   Search Chromatin IP Primers for ISG20

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISG20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26

ISG20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISG20 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P089181:  view genomic region     (about GC identifiers)

Start:
89,179,384 bp from pter      End:
89,199,714 bp from pter
Size:
20,331 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6 (See protein sequence)
Recommended Name: Interferon-stimulated gene 20 kDa protein  
Size: 181 amino acids; 20363 Da
Cofactor: Binds 2 manganese ions per subunit
Subunit: Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein
(SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA
1 PDB 3D structure from and Proteopedia for ISG20:
1WLJ (3D)    
Secondary accessions: O00441 O00586
Alternative splicing: 2 isoforms:  Q96AZ6-1   Q96AZ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ISG20: NX_Q96AZ6

Explore proteomics data for ISG20 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ISG20 (Q96AZ6)
     HSSVEDA  VGHDLKHD 


    See ISG20 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002192.2  
    ENSEMBL proteins: 
     ENSP00000453638   ENSP00000306565   ENSP00000368526   ENSP00000453666  
    Reactome Protein details: Q96AZ6

    ISG20 Human Recombinant Protein Products:

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    Novus Biologicals ISG20 Protein
    Novus Biologicals ISG20 Lysates
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    ISG20 Assay Products:

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    Cloud-Clone Corp. ELISAs for ISG20
    Cloud-Clone Corp. CLIAs for ISG20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96AZ6

    ProtoNet protein and cluster: Q96AZ6

    2 Blocks protein domains:
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6
    Similarity: Belongs to the exonuclease superfamily


    ISG20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISG20_HUMAN, Q96AZ6
    Function: Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor
    activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus
    (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play
    additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis
    Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0;
    Induction: Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased
    expression was seen at the transcriptional level

         Genatlas biochemistry entry for ISG20:
    interferon stimulated PML nuclear body associated protein 20kDa,Xenopus XPMC2 homolog

         Enzyme Number (IUBMB): EC 3.1.13.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IDA11401564
    GO:0003676nucleic acid binding ----
    GO:0004527exonuclease activity IMP--
    GO:0008310single-stranded DNA 3'-5' exodeoxyribonuclease activity IDA11401564
    GO:0008859exoribonuclease II activity IEA--
         
    ISG20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ISG20:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISG20
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISG20
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISG20

    miRNA
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    miRTarBase miRNAs that target ISG20:
    hsa-mir-335-5p (MIRT018907), hsa-mir-1 (MIRT024004)

    Block miRNA regulation of human, mouse, rat ISG20 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ISG20

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ISG20 (NM_002201)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISG20
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISG20

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ISG20_HUMAN, Q96AZ6: Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA16514659
    GO:0005737cytoplasm IDA16514659
    GO:0015030Cajal body IDA16514659

    ISG20 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ISG20 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    Cytokine Signaling in Immune system0.59
    2Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ISG20
        Interferon alpha/beta signaling



    ISG20 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ISG20: 
              Th17 Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ISG20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ISG20 (Q96AZ63 ENSP000003065654) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF1P109143, ENSP000002454144I2D: score=1 STRING: ENSP00000245414
    NFKB1P198383I2D: score=1 
    RELAQ042063I2D: score=1 
    ADARENSP000003574594STRING: ENSP00000357459
    EGR1ENSP000002399384STRING: ENSP00000239938
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000738DNA catabolic process, exonucleolytic IDA11401564
    GO:0006364rRNA processing IEA--
    GO:0006401RNA catabolic process IDA11401564
    GO:0008283cell proliferation TAS9569007
    GO:0009615response to virus IDA12594219

    ISG20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISG20

    1 HMDB Compound for ISG20    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--

    1 DrugBank Compound for ISG20    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Uridine-5'-Monophosphate-- 58-97-9target--17139284 17016423

    8 Novoseek inferred chemical compound relationships for ISG20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 69.1 2 20046508 (1), 17669408 (1)
    5-methylthioadenosine 67 4 7825061 (1), 1385305 (1), 8689637 (1), 8689636 (1)
    2-methoxyestradiol 45.8 6 11856647 (2), 17014383 (2)
    ribavirin 29.6 2 10581390 (1), 18713278 (1)
    adenine 4.74 1 2219731 (1)
    oligonucleotide 3.45 1 18352910 (1)
    tyrosine 0 1 8537333 (1)
    estrogen 0 1 11401564 (1)



    ISG20 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ISG20 gene: 
    NM_002201.4  

    Unigene Cluster for ISG20:

    Interferon stimulated exonuclease gene 20kDa
    Hs.459265  [show with all ESTs]
    Unigene Representative Sequence: AB209639
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560741 ENST00000558992 ENST00000306072(uc002bmv.1) ENST00000379224
    ENST00000559876 ENST00000558942 ENST00000560573(uc002bmu.1 uc010upn.1)
    ENST00000557824 ENST00000558236 ENST00000560746 ENST00000546338
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat ISG20
      QuantiFast Probe-based Assays in human, mouse, rat ISG20

    Additional mRNA sequence: 

    AB209639.1 AK122793.1 AK307769.1 BC007922.2 BC016341.1 BT006952.1 CR456942.1 U88964.1 
    X89773.2 

    11 DOTS entries:

    DT.213778  DT.100641175  DT.95272298  DT.95313299  DT.100026436  DT.101975462  DT.100819030  DT.121014585 
    DT.75102836  DT.40118787  DT.95219058 

    Selected AceView cDNA sequences (see all 142):

    BE675647 CD672839 BG684223 AW966891 AW009108 CR625782 CB114442 BX490703 
    CR619922 CB126685 CB125863 AA470680 BG684672 AJ714720 AI283917 BG744069 
    CB114498 CB126461 BM754903 CB125783 CB125224 AA503824 BG775406 U88964 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ISG20 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                          -           -     -                                 
    SP2:                          -           -     -     -                           
    SP3:        -     -     -     -           -     -                                 
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for ISG20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ISG20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGCTACA
    ISG20 Expression
    About this image


    ISG20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Fibroblasts
             Dermal Fibroblasts Dorsal Dermis
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis
     
     Tonsil (Hematopoietic System)
     
     Placenta (Extraembryonic Tissues)
    ISG20 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISG20 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459265

    UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6
    Tissue specificity: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated
    by E2 in estrogen receptor-positive breast cancer lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ISG20: 
              Th17 Response in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ISG20
    OriGene qSTAR qPCR primer pairs in human, mouse for ISG20
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISG20
    QuantiTect SYBR Green Assays in human, mouse, rat ISG20
    QuantiFast Probe-based Assays in human, mouse, rat ISG20
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ISG20 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isg201 , 5 interferon-stimulated protein1, 5 83.06(n)1
    81.77(a)1
      7 (44.84 cM)5
    574441  NM_020583.51  NP_065608.21 
     789134245 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX46
    Putative RNA exonuclease possibly involved in pre-...
    24(a)
    1 → many
    XV(180558-181427) YOL080C


    ENSEMBL Gene Tree for ISG20 (if available)
    TreeFam Gene Tree for ISG20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ISG20 gene
    REXO42  AEN2  ISG20L22  
    7 SIMAP similar genes for ISG20 using alignment to 3 protein entries:     ISG20_HUMAN (see all proteins):
    AEN    ISG20L2    pp12744    LOC81691    REXO1    REXO1L10P
    REXO1L1

    ISG20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ISG20 (see all 458)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881930241,2
    --65291954(+) GCAGGA/GAGTGC 1 -- us2k10--------
    rs2004731201,2
    C--65292119(+) AAGAC-/AGAA  
            
    AGAGC
    1 -- us2k10--------
    rs1389197251,2
    --65292169(+) GGGCAC/TGGGAG 1 -- us2k10--------
    rs64965141,2
    C,F,A,H--65292197(+) GCACTG/TCCTGT 1 -- us2k1 tfbs327Minor allele frequency- T:0.26NS EA NA WA CSA 2358
    rs1494301001,2
    --65292209(+) TCTTCC/TACCTG 1 -- us2k10--------
    rs789911161,2
    F--65292220(+) AAGCAG/CAGACC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1157332051,2
    C,F--65292231(+) TGATCT/CTACTG 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs1448622341,2
    --65292282(+) GGGTTC/TCAGAA 1 -- us2k10--------
    rs45661361,2
    C,F,A,H--65292414(+) GTGGAT/CTGATG 1 -- us2k1 tfbs316Minor allele frequency- C:0.49NS EA NA WA 1154
    rs1485562461,2
    --65292513(+) TGCCTC/TGGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ISG20 (89179384 - 89199714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ISG20:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904477CNV Loss21882294
    nsv827428CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISG20
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604533    OMIM disorders: --

    Selected diseases for ISG20 (see all 47):    
    About MalaCards
    mast-cell leukemia    crimean-congo hemorrhagic fever    mumps    estrogen-receptor positive breast cancer
    balanitis    malignant glioma    chondrosarcoma    rubella
    myxoid chondrosarcoma    neurofibroma    leukemia    cytomegalovirus infection
    squamous cell carcinoma of the head and neck    hepatitis c    osteosarcoma    herpes simplex
    vaginitis    hemorrhagic fever    influenza    stomatitis


    ISG20 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for ISG20 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 43.7 9 18352910 (2), 15064705 (1), 18338947 (1), 14668931 (1) (see all 6)
    hepatitis c chronic 32.6 2 17302252 (1), 16731032 (1)
    lymphoblastic leukemia acute 32 3 2294436 (1), 1886420 (1), 1694263 (1)
    tumors 19.9 8 7825061 (1), 11687902 (1), 20140953 (1), 8462339 (1) (see all 7)
    leukemia 19.6 1 8158846 (1)
    melanoma 19.1 1 8687130 (1)
    chondrosarcoma 17.9 1 8689637 (1)
    hepatitis c 13 1 18338947 (1)
    malignant glioma 11.6 2 1598130 (1), 1501894 (1)
    lupus erythematosus systemic 8.01 2 15840221 (1), 19633559 (1)

    Genetic Association Database (GAD): ISG20

    Export disorders for ISG20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISG20 gene, integrated from 10 sources (see all 141):
    (articles sorted by number of sources associating them with ISG20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a new interferon-induced PML nuclear bodies- associated protein. (PubMed id 9235947)1, 2, 3, 9 Gongora C....Mechti N. (J. Biol. Chem. 1997)
    2. The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes. (PubMed id 16514659)1, 2, 9 Espert L....Mechti N. (J. Cell. Biochem. 2006)
    3. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. (PubMed id 12594219)1, 2, 9 Espert L.... Mechti N. (J. Biol. Chem. 2003)
    4. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. (PubMed id 11401564)1, 2, 9 Nguyen L.H.... Wilson D.M. III (Biochemistry 2001)
    5. Antiviral activities of ISG20 in positive-strand RNA virus infections. (PubMed id 21036379)1, 2 Zhou Z....Li K. (Virology 2011)
    6. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1, 4 Dolmans G.H.... . (N. Engl. J. Med. 2011)
    7. Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease. (PubMed id 15527770)1, 2 Horio T.... Ohgi T. (FEBS Lett. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus. (PubMed id 9569007)1, 2 Pentecost B.T. (J. Steroid Biochem. Mol. Biol. 1998)
    10. Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization. (PubMed id 9605874)1, 3 Mattei M.G....Mechti N. (Cytogenet. Cell Genet. 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3669 HGNC: 6130 AceView: ISG20 Ensembl:ENSG00000172183 euGenes: HUgn3669
    ECgene: ISG20 H-InvDB: ISG20

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ISG20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ISG20 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISG20 gene:
    Search GeneIP for patents involving ISG20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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