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Aliases for ISG20 Gene

Aliases for ISG20 Gene

  • Interferon Stimulated Exonuclease Gene 20kDa 2 3 5
  • Promyelocytic Leukemia Nuclear Body-Associated Protein ISG20 3 4
  • Estrogen-Regulated Transcript 45 Protein 3 4
  • EC 3.1.13.1 4 63
  • HEM45 3 4
  • Interferon Stimulated Gene (20kD) 2
  • CD25 3

External Ids for ISG20 Gene

Previous GeneCards Identifiers for ISG20 Gene

  • GC15P085474
  • GC15P082547
  • GC15P086766
  • GC15P086911
  • GC15P086983
  • GC15P089181
  • GC15P065293

Summaries for ISG20 Gene

GeneCards Summary for ISG20 Gene

ISG20 (Interferon Stimulated Exonuclease Gene 20kDa) is a Protein Coding gene. Diseases associated with ISG20 include mast cell disease and hepatitis c virus. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include nucleic acid binding and 3-5-exoribonuclease activity. An important paralog of this gene is AEN.

UniProtKB/Swiss-Prot for ISG20 Gene

  • Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

Gene Wiki entry for ISG20 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISG20 Gene

Genomics for ISG20 Gene

Regulatory Elements for ISG20 Gene

Promoters for ISG20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ISG20 on UCSC Golden Path with GeneCards custom track

Genomic Location for ISG20 Gene

Chromosome:
15
Start:
88,635,622 bp from pter
End:
88,656,483 bp from pter
Size:
20,862 bases
Orientation:
Plus strand

Genomic View for ISG20 Gene

Genes around ISG20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ISG20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ISG20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISG20 Gene

Proteins for ISG20 Gene

  • Protein details for ISG20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AZ6-ISG20_HUMAN
    Recommended name:
    Interferon-stimulated gene 20 kDa protein
    Protein Accession:
    Q96AZ6
    Secondary Accessions:
    • O00441
    • O00586

    Protein attributes for ISG20 Gene

    Size:
    181 amino acids
    Molecular mass:
    20363 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Associates with PML and SP100 in the PML NB complex. Associates with survival motor neuron protein (SMN)-containing macromolecular nuclear complexes and U1 and U2 snRNAs and U3 snoRNA.

    Three dimensional structures from OCA and Proteopedia for ISG20 Gene

    Alternative splice isoforms for ISG20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ISG20 Gene

Proteomics data for ISG20 Gene at MOPED

Selected DME Specific Peptides for ISG20 Gene

Post-translational modifications for ISG20 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for ISG20 Gene

Gene Families for ISG20 Gene

Suggested Antigen Peptide Sequences for ISG20 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AZ6

UniProtKB/Swiss-Prot:

ISG20_HUMAN :
  • Belongs to the exonuclease superfamily.
Family:
  • Belongs to the exonuclease superfamily.
genes like me logo Genes that share domains with ISG20: view

Function for ISG20 Gene

Molecular function for ISG20 Gene

GENATLAS Biochemistry:
interferon stimulated PML nuclear body associated protein 20kDa,Xenopus XPMC2 homolog
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0.;
UniProtKB/Swiss-Prot CatalyticActivity:
Exonucleolytic cleavage in the 3- to 5-direction to yield nucleoside 5-phosphates.
UniProtKB/Swiss-Prot Function:
Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.
UniProtKB/Swiss-Prot Induction:
Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased expression was seen at the transcriptional level.

Enzyme Numbers (IUBMB) for ISG20 Gene

Gene Ontology (GO) - Molecular Function for ISG20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008310 single-stranded DNA 3-5 exodeoxyribonuclease activity IDA 11401564
genes like me logo Genes that share ontologies with ISG20: view
genes like me logo Genes that share phenotypes with ISG20: view

Animal Model Products

miRNA for ISG20 Gene

miRTarBase miRNAs that target ISG20

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ISG20 Gene

Localization for ISG20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISG20 Gene

Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISG20 Gene COMPARTMENTS Subcellular localization image for ISG20 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ISG20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16514659
GO:0016605 PML body IDA 9235947
genes like me logo Genes that share ontologies with ISG20: view

Pathways & Interactions for ISG20 Gene

genes like me logo Genes that share pathways with ISG20: view

Pathways by source for ISG20 Gene

Gene Ontology (GO) - Biological Process for ISG20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006401 RNA catabolic process IDA 11401564
GO:0008283 cell proliferation TAS 9569007
GO:0009615 response to virus IDA 12594219
genes like me logo Genes that share ontologies with ISG20: view

No data available for SIGNOR curated interactions for ISG20 Gene

Drugs & Compounds for ISG20 Gene

(7) Drugs for ISG20 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Monophosphate Experimental Pharma Target 0
Manganese Pharma 32

(3) Additional Compounds for ISG20 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ISG20: view

Transcripts for ISG20 Gene

Unigene Clusters for ISG20 Gene

Interferon stimulated exonuclease gene 20kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISG20 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: - - - - - -
SP4: -
SP5:
SP6:

Relevant External Links for ISG20 Gene

GeneLoc Exon Structure for
ISG20
ECgene alternative splicing isoforms for
ISG20

Expression for ISG20 Gene

mRNA expression in normal human tissues for ISG20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ISG20 Gene

This gene is overexpressed in Whole Blood (x11.7) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for ISG20 Gene

This gene is overexpressed in Tlymphocyte (15.6), Lymph node (15.5), and Blymphocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISG20 Gene



SOURCE GeneReport for Unigene cluster for ISG20 Gene Hs.459265

mRNA Expression by UniProt/SwissProt for ISG20 Gene

Q96AZ6-ISG20_HUMAN
Tissue specificity: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung. Up regulated by E2 in estrogen receptor-positive breast cancer lines.
genes like me logo Genes that share expression patterns with ISG20: view

Protein tissue co-expression partners for ISG20 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ISG20 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ISG20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISG20 36
  • 39 (a)
OneToOne
ISG20 35
  • 80.37 (n)
  • 77.78 (a)
cow
(Bos Taurus)
Mammalia ISG20 35
  • 82.25 (n)
  • 79.29 (a)
ISG20 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ISG20 36
  • 77 (a)
OneToOne
ISG20 35
  • 82.46 (n)
  • 80.7 (a)
mouse
(Mus musculus)
Mammalia Isg20 35
  • 83.06 (n)
  • 81.77 (a)
Isg20 36
  • 82 (a)
OneToOne
Isg20 16
oppossum
(Monodelphis domestica)
Mammalia ISG20 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ISG20 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Isg20 35
  • 82.78 (n)
  • 80.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes REX4 36
  • 24 (a)
OneToMany
Species with no ortholog for ISG20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ISG20 Gene

ENSEMBL:
Gene Tree for ISG20 (if available)
TreeFam:
Gene Tree for ISG20 (if available)

Paralogs for ISG20 Gene

Paralogs for ISG20 Gene

(7) SIMAP similar genes for ISG20 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ISG20: view

Variants for ISG20 Gene

Sequence variations from dbSNP and Humsavar for ISG20 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs3200942 -- 88,639,365(+) AAGGA(A/G)CATGG intron-variant, utr-variant-5-prime
rs4499212 -- 88,648,473(+) CCTGG(C/T)CTGGC intron-variant
rs4566136 -- 88,637,290(+) GTGGA(C/T)TGATG intron-variant, upstream-variant-2KB
rs4491485 -- 88,637,515(+) CGGCC(A/G)CACAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs4932188 -- 88,649,790(+) AGCAG(C/G)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ISG20 Gene

Variant ID Type Subtype PubMed ID
nsv827428 CNV Loss 20364138
nsv904477 CNV Loss 21882294

Variation tolerance for ISG20 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ISG20 Gene

HapMap Linkage Disequilibrium report
ISG20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISG20 Gene

Disorders for ISG20 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ISG20 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
mast cell disease
  • mastocytosis
hepatitis c virus
  • hepatitic c virus
aicardi-goutieres syndrome
  • cree encephalitis
- elite association - COSMIC cancer census association via MalaCards
Search ISG20 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ISG20

Genetic Association Database (GAD)
ISG20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ISG20
genes like me logo Genes that share disorders with ISG20: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ISG20 Gene

Publications for ISG20 Gene

  1. Molecular cloning of a new interferon-induced PML nuclear bodies- associated protein. (PMID: 9235947) Gongora C. … Mechti N. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes. (PMID: 16514659) Espert L. … Mechti N. (J. Cell. Biochem. 2006) 3 23
  5. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. (PMID: 12594219) Espert L. … Mechti N. (J. Biol. Chem. 2003) 3 23

Products for ISG20 Gene

Sources for ISG20 Gene

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