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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ISG20 Gene

protein-coding   GIFtS: 62
GCID: GC15P089181

Interferon Stimulated Exonuclease Gene 20kDa

(Previous name: interferon stimulated gene (20kD))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Stimulated Exonuclease Gene 20kDa1 2     EC 3.1.13.13 8
HEM452 3 5     Interferon Stimulated Gene (20kD)1
Estrogen-Regulated Transcript 45 Protein2 3     CD252
Promyelocytic Leukemia Nuclear Body-Associated Protein ISG202 3     Interferon-Stimulated Gene 20 KDa Protein2

External Ids:    HGNC: 61301   Entrez Gene: 36692   Ensembl: ENSG000001721837   OMIM: 6045335   UniProtKB: Q96AZ63   

Export aliases for ISG20 gene to outside databases

Previous GC identifers: GC15P085474 GC15P082547 GC15P086766 GC15P086911 GC15P086983 GC15P065293


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ISG20 Gene: 
ISG20 (interferon stimulated exonuclease gene 20kDa) is a protein-coding gene. Diseases associated with ISG20 include mast-cell leukemia, and crimean-congo hemorrhagic fever, and among its related super-pathways are Interferon Signaling and Adaptive Immune System. GO annotations related to this gene include single-stranded DNA 3'-5' exodeoxyribonuclease activity and RNA binding. An important paralog of this gene is REXO4.

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6
Function: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a
rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral
function of IFN against RNA viruses
Function: Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs
and rRNAs, and in ribosome biogenesis

Gene Wiki entry for ISG20 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ISG20 gene promoter:
         AREB6   STAT1   Tal-1   Hand1   En-1   E47   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ISG20 promoter sequence
   Search SABiosciences Chromatin IP Primers for ISG20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISG20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26

ISG20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISG20 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P089181:  view genomic region     (about GC identifiers)

Start:
89,179,384 bp from pter      End:
89,199,714 bp from pter
Size:
20,331 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6 (See protein sequence)
Recommended Name: Interferon-stimulated gene 20 kDa protein  
Size: 181 amino acids; 20363 Da
Cofactor: Binds 2 manganese ions per subunit
Subunit: Associates with PML and SP100 in the PML NB complex
Subcellular location: Nucleus
Miscellaneous: Stable and constitutive expression confers resistance to vesicular stomatitis virus (VSV),
influenza virus, and encephalomyocarditis virus (EMCV) infection in HeLa cells, providing an alternative
antiviral pathway against RNA genomic viruses. Up regulated by E2 in estrogen receptor-positive breast cancer
lines
1 PDB 3D structure from and Proteopedia for ISG20:
1WLJ (3D)    
Secondary accessions: O00441 O00586
Alternative splicing: 2 isoforms:  Q96AZ6-1   Q96AZ6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ISG20: NX_Q96AZ6

Explore proteomics data for ISG20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96AZ6

  • 2 DME Specific Peptides for ISG20 (Q96AZ6)
     HSSVEDA  VGHDLKHD 

    ISG20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ISG20 Protein Expression
    REFSEQ proteins: NP_002192.2  
    ENSEMBL proteins: 
     ENSP00000453638   ENSP00000306565   ENSP00000368526   ENSP00000453666  
    Reactome Protein details: Q96AZ6
    Human Recombinant Protein Products for ISG20: 
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    Novus Biologicals ISG20 Protein
    Novus Biologicals ISG20 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISG20 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus IDA16514659
    GO:0005737cytoplasm IDA16514659

    ISG20 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ISG20


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR013520 Exonuclease_RNaseT/DNA_pol3
     IPR006055 Exonuclease
     IPR012337 RNaseH-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96AZ6

    ProtoNet protein and cluster: Q96AZ6

    2 Blocks protein domains:
    IPB006055 Exonuclease
    IPB013520 Exonuclease


    UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6
    Similarity: Belongs to the exonuclease superfamily


    ISG20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISG20_HUMAN, Q96AZ6
    Function: Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a
    rate that is approximately 35-fold higher than its rate for single-stranded DNA. Involved in the antiviral
    function of IFN against RNA viruses
    Function: Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs
    and rRNAs, and in ribosome biogenesis
    Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
    Biophysicochemical properties: pH dependence: Optimum pH is 7.0;
    Induction: Induced by interferons alpha and beta. Weaker induction was seen with interferon gamma. Increased
    expression was seen at the transcriptional level

         Genatlas biochemistry entry for ISG20:
    interferon stimulated PML nuclear body associated protein 20kDa,Xenopus XPMC2 homolog

         Enzyme Number (IUBMB): EC 3.1.13.11 2

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00001753'-5'-exoribonuclease activity IDA11401564
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004527exonuclease activity IMP--
    GO:0008310single-stranded DNA 3'-5' exodeoxyribonuclease activity IDA11401564
         
    ISG20 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ISG20:
     Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ISG20 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ISG20

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISG20 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ISG20 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.61
    Cytokine Signaling in Immune system0.61
    2Immune System
    Immune System0.56
    3Immune response IFN alpha/beta signaling pathway
    Interferon alpha/beta signaling0.45

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for ISG20
        Interferon alpha/beta signaling
    Cytokine Signaling in Immune system
    Interferon Signaling
    Immune System



    ISG20 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ISG20

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for ISG20 (Q96AZ63 ENSP000003065654) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF1P109143, ENSP000002454144I2D: score=1 STRING: ENSP00000245414
    NFKB1P198383I2D: score=1 
    RELAQ042063I2D: score=1 
    ADARENSP000003574594STRING: ENSP00000357459
    EGR1ENSP000002399384STRING: ENSP00000239938
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000738DNA catabolic process, exonucleolytic IDA11401564
    GO:0006364rRNA processing IEA--
    GO:0006401RNA catabolic process IDA11401564
    GO:0008283cell proliferation TAS9569007
    GO:0009615response to virus IDA12594219

    ISG20 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ISG20 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ISG20

    1 HMDB Compound for ISG20    About this table
    CompoundSynonyms CAS #PubMed Ids
    Manganesemanganese 7439-96-5--

    1 DrugBank Compound for ISG20    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Uridine-5'-Monophosphate-- 58-97-9target--17139284 17016423

    8 Novoseek inferred chemical compound relationships for ISG20 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 69.1 2 20046508 (1), 17669408 (1)
    5-methylthioadenosine 67 4 7825061 (1), 1385305 (1), 8689637 (1), 8689636 (1)
    2-methoxyestradiol 45.8 6 11856647 (2), 17014383 (2)
    ribavirin 29.6 2 10581390 (1), 18713278 (1)
    adenine 4.74 1 2219731 (1)
    oligonucleotide 3.45 1 18352910 (1)
    tyrosine 0 1 8537333 (1)
    estrogen 0 1 11401564 (1)

    Search CenterWatch for drugs/clinical trials and news about ISG20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ISG20 gene: 
    NM_002201.4  

    Unigene Cluster for ISG20:

    Interferon stimulated exonuclease gene 20kDa
    Hs.459265  [show with all ESTs]
    Unigene Representative Sequence: AB209639
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560741 ENST00000558992 ENST00000306072(uc002bmv.1) ENST00000379224
    ENST00000559876 ENST00000558942 ENST00000560573(uc002bmu.1 uc010upn.1)
    ENST00000557824 ENST00000558236 ENST00000560746 ENST00000546338
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB209639.1 AK122793.1 AK307769.1 BC007922.2 BC016341.1 BT006952.1 CR456942.1 U88964.1 
    X89773.2 

    11 DOTS entries:

    DT.213778  DT.100641175  DT.95272298  DT.95313299  DT.100026436  DT.101975462  DT.100819030  DT.121014585 
    DT.75102836  DT.40118787  DT.95219058 

    24/142 AceView cDNA sequences (see all 142):

    CB125863 BG744069 AI283917 CB126685 AA470680 AW966891 BG684223 CB125783 
    AW009108 CB126461 BG684672 AJ714720 CB114442 CR619922 CD672839 CB125224 
    CB114498 CR625782 BE675647 BM754903 BX490703 BE646037 BM684740 BI759236 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ISG20 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
    SP1:                          -           -     -                                 
    SP2:                          -           -     -     -                           
    SP3:        -     -     -     -           -     -                                 
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for ISG20

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ISG20 expression in normal human tissues (normalized intensities)      ISG20 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGGCTACA
    ISG20 Expression
    About this image


    ISG20 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor F15
     
     Thymus (Hematopoietic System)
             Thymus   
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Dermis (Integumentary System)
             Dermal Fibroblasts Dorsal Dermis

    See ISG20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ISG20

    SOURCE GeneReport for Unigene cluster: Hs.459265

    UniProtKB/Swiss-Prot: ISG20_HUMAN, Q96AZ6
    Tissue specificity: Highly expressed in peripheral blood leukocytes, spleen, thymus, colon and lung

        SABiosciences Expression via Pathway-Focused PCR Arrays including ISG20: 
              Th17 Response in human mouse rat
              Type I Interferon Response in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISG20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ISG20 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isg201 , 5 interferon-stimulated protein1, 5 83.06(n)1
    81.77(a)1
      7 (44.84 cM)5
    574441  NM_001113527.11  NP_001106999.11 
     789134245 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG68336
    --
    22(a)
    1 → many
    3L(14044306-14045569)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes REX46
    Putative RNA exonuclease possibly involved in pre-...
    23(a)
    1 → many
    XV(180558-181427)


    ENSEMBL Gene Tree for ISG20 (if available)
    TreeFam Gene Tree for ISG20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ISG20 gene
    REXO42  AEN2  ISG20L22  
    8 SIMAP similar genes for ISG20 using alignment to 3 protein entries:     ISG20_HUMAN (see all proteins):
    AEN    ISG20L2    pp12744    LOC81691    REXO1    REXO1L10P
    REXO1L1    REXO1L2P

    ISG20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/458 SNPs in ISG20 are shown (see all 458)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881930241,2
    --65291954(+) GCAGGA/GAGTGC 1 -- us2k10--------
    rs2004731201,2
    C--65292119(+) AAGAC-/AGAA  
            
    AGAGC
    1 -- us2k10--------
    rs1389197251,2
    --65292169(+) GGGCAC/TGGGAG 1 -- us2k10--------
    rs64965141,2
    C,F,A,H--65292197(+) GCACTG/TCCTGT 1 -- us2k1 tfbs327Minor allele frequency- T:0.26NS EA NA WA CSA 2358
    rs1494301001,2
    --65292209(+) TCTTCC/TACCTG 1 -- us2k10--------
    rs789911161,2
    F--65292220(+) AAGCAG/CAGACC 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs1157332051,2
    C,F--65292231(+) TGATCT/CTACTG 1 -- us2k12Minor allele frequency- C:0.02WA NA 238
    rs1448622341,2
    --65292282(+) GGGTTC/TCAGAA 1 -- us2k10--------
    rs45661361,2
    C,F,A,H--65292414(+) GTGGAT/CTGATG 1 -- us2k1 tfbs316Minor allele frequency- C:0.49NS EA NA WA 1154
    rs1485562461,2
    --65292513(+) TGCCTC/TGGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ISG20 (89179384 - 89199714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ISG20:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv904477CNV Loss21882294
    nsv827428CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604533    OMIM disorders: --

    20/46 diseases for ISG20 (see all 46):    About MalaCards
    mast-cell leukemia    crimean-congo hemorrhagic fever    balanitis    estrogen-receptor positive breast cancer
    mumps    malignant glioma    rubella    myxoid chondrosarcoma
    chondrosarcoma    cytomegalovirus infection    neurofibroma    squamous cell carcinoma of the head and neck
    vaginitis    leukemia    herpes simplex    hepatitis c
    hiv type 1    osteosarcoma    hemorrhagic fever    stomatitis


    ISG20 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/23 Novoseek inferred disease relationships for ISG20 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 43.7 9 18352910 (2), 15064705 (1), 18338947 (1), 14668931 (1) (see all 6)
    hepatitis c chronic 32.6 2 17302252 (1), 16731032 (1)
    lymphoblastic leukemia acute 32 3 2294436 (1), 1886420 (1), 1694263 (1)
    tumors 19.9 8 7825061 (1), 11687902 (1), 20140953 (1), 8462339 (1) (see all 7)
    leukemia 19.6 1 8158846 (1)
    melanoma 19.1 1 8687130 (1)
    chondrosarcoma 17.9 1 8689637 (1)
    hepatitis c 13 1 18338947 (1)
    malignant glioma 11.6 2 1598130 (1), 1501894 (1)
    lupus erythematosus systemic 8.01 2 15840221 (1), 19633559 (1)

    Genetic Association Database (GAD): ISG20

    Export disorders for ISG20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ISG20 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with ISG20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a new interferon-inductible PML nuclear bodies- associated protein. (PubMed id 9235947)1, 2, 3, 9 Gongora C....Mechti N. (1997)
    2. ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses. (PubMed id 12594219)1, 2, 9 Espert L.... Mechti N. (2003)
    3. The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro. (PubMed id 11401564)1, 2, 9 Nguyen L.H.... Wilson D.M. III (2001)
    4. Wnt signaling and Dupuytren's disease. (PubMed id 21732829)1, 4 Dolmans G.H.... . (2011)
    5. Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease. (PubMed id 15527770)1, 2 Horio T....Ohgi T. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus. (PubMed id 9569007)1, 2 Pentecost B.T. (1998)
    8. Assignment of ISG20 encoding a new interferon-induced PML nuclear body-associated protein, to chromosome 15q26 by in situ hybridization. (PubMed id 9605874)1, 3 Mattei M.G....Mechti N. (1997)
    9. The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes. (PubMed id 16514659)1, 9 Espert L....Mechti N. (2006)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3669 HGNC: 6130 AceView: ISG20 Ensembl:ENSG00000172183 euGenes: HUgn3669
    ECgene: ISG20 H-InvDB: ISG20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ISG20 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ISG20 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ISG20 gene:
    Search GeneIP for patents involving ISG20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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