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Aliases for ISCA2 Gene

Aliases for ISCA2 Gene

  • Iron-Sulfur Cluster Assembly 2 2 3
  • HESB-Like Domain-Containing Protein 1 3 4
  • HBLD1 3 4
  • Iron-Sulfur Cluster Assembly 2 Homolog (S. Cerevisiae) 2
  • Iron-Sulfur Cluster Assembly 2 Homolog, Mitochondrial 3
  • HesB Like Domain Containing 1 2
  • C14_5557 3
  • ISA2 3

External Ids for ISCA2 Gene

Previous HGNC Symbols for ISCA2 Gene

  • HBLD1

Previous GeneCards Identifiers for ISCA2 Gene

  • GC14P074031
  • GC14P074960
  • GC14P055128

Summaries for ISCA2 Gene

Entrez Gene Summary for ISCA2 Gene

  • The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

GeneCards Summary for ISCA2 Gene

ISCA2 (Iron-Sulfur Cluster Assembly 2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and iron-sulfur cluster binding.

UniProtKB/Swiss-Prot for ISCA2 Gene

  • Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ISCA2 Gene

Genomics for ISCA2 Gene

Regulatory Elements for ISCA2 Gene

Genomic Location for ISCA2 Gene

Start:
74,493,720 bp from pter
End:
74,497,106 bp from pter
Size:
3,387 bases
Orientation:
Plus strand

Genomic View for ISCA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ISCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ISCA2 Gene

Proteins for ISCA2 Gene

  • Protein details for ISCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86U28-ISCA2_HUMAN
    Recommended name:
    Iron-sulfur cluster assembly 2 homolog, mitochondrial
    Protein Accession:
    Q86U28
    Secondary Accessions:
    • A6NFF1
    • A8K3W3
    • G3V291
    • Q8IYZ0
    • Q96BB2

    Protein attributes for ISCA2 Gene

    Size:
    154 amino acids
    Molecular mass:
    16476 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62580.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ISCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ISCA2 Gene

Proteomics data for ISCA2 Gene at MOPED

Post-translational modifications for ISCA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ISCA2 Gene

No data available for DME Specific Peptides for ISCA2 Gene

Domains for ISCA2 Gene

Suggested Antigen Peptide Sequences for ISCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86U28

UniProtKB/Swiss-Prot:

ISCA2_HUMAN :
  • Q86U28
Family:
  • Belongs to the HesB/IscA family.
genes like me logo Genes that share domains with ISCA2: view

No data available for Gene Families for ISCA2 Gene

Function for ISCA2 Gene

Molecular function for ISCA2 Gene

UniProtKB/Swiss-Prot Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.

Gene Ontology (GO) - Molecular Function for ISCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with ISCA2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ISCA2 Gene

Localization for ISCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ISCA2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ISCA2 Gene COMPARTMENTS Subcellular localization image for ISCA2 gene
Compartment Confidence
mitochondrion 3
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ISCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ISCA2: view

Pathways for ISCA2 Gene

SuperPathways for ISCA2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ISCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 iron-sulfur cluster assembly IEA --
genes like me logo Genes that share ontologies with ISCA2: view

No data available for Pathways by source for ISCA2 Gene

Compounds for ISCA2 Gene

(1) HMDB Compounds for ISCA2 Gene

Compound Synonyms Cas Number PubMed IDs
Iron
  • Armco iron
7439-89-6
genes like me logo Genes that share compounds with ISCA2: view

Transcripts for ISCA2 Gene

Unigene Clusters for ISCA2 Gene

Iron-sulfur cluster assembly 2 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ISCA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2:

Relevant External Links for ISCA2 Gene

GeneLoc Exon Structure for
ISCA2
ECgene alternative splicing isoforms for
ISCA2

Expression for ISCA2 Gene

mRNA expression in normal human tissues for ISCA2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ISCA2 Gene

SOURCE GeneReport for Unigene cluster for ISCA2 Gene Hs.291079

genes like me logo Genes that share expressions with ISCA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ISCA2 Gene

Orthologs for ISCA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ISCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ISCA2 35
  • 99.78 (n)
  • 99.35 (a)
ISCA2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ISCA2 35
  • 90.13 (n)
  • 87.5 (a)
ISCA2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ISCA2 35
  • 91.77 (n)
  • 88.96 (a)
ISCA2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Isca2 35
  • 85.71 (n)
  • 83.77 (a)
Isca2 16
Isca2 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ISCA2 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Isca2 35
  • 85.71 (n)
  • 83.77 (a)
chicken
(Gallus gallus)
Aves ISCA2 35
  • 68.21 (n)
  • 70.2 (a)
ISCA2 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ISCA2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia isca2 35
  • 58.82 (n)
  • 62.5 (a)
zebrafish
(Danio rerio)
Actinopterygii ISCA2 36
  • 49 (a)
OneToOne
LOC100150438 35
  • 66.98 (n)
  • 68.52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010072 35
  • 52.5 (n)
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13623 35
  • 57.14 (n)
  • 53.78 (a)
CG13623 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y54G11A.9 35
  • 55.2 (n)
  • 50.4 (a)
Y54G11A.9 36
  • 47 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISA2 36
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G03905 35
  • 48.81 (n)
  • 51.43 (a)
rice
(Oryza sativa)
Liliopsida Os08g0369700 35
  • 53.43 (n)
  • 51.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6700 36
  • 41 (a)
OneToOne
Species with no ortholog for ISCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ISCA2 Gene

ENSEMBL:
Gene Tree for ISCA2 (if available)
TreeFam:
Gene Tree for ISCA2 (if available)

Paralogs for ISCA2 Gene

Selected SIMAP similar genes for ISCA2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ISCA2 Gene

genes like me logo Genes that share paralogs with ISCA2: view

No data available for Paralogs for ISCA2 Gene

Variants for ISCA2 Gene

Sequence variations from dbSNP and Humsavar for ISCA2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs3759745 -- 74,495,967(-) GGTCA(A/G)CAAAT downstream-variant-500B
rs4903231 -- 74,495,530(+) TTCCT(A/G)TTTGA utr-variant-3-prime
rs11159086 -- 74,495,572(+) GGATC(C/T)GCTAT downstream-variant-500B
rs142827133 -- 74,495,798(+) ATAGG(C/T)AATAG downstream-variant-500B
rs183717244 -- 74,496,045(+) TGTGT(A/G)GGTGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ISCA2 Gene

Variant ID Type Subtype PubMed ID
nsv832829 CNV Loss 17160897
nsv902099 CNV Loss 21882294

Relevant External Links for ISCA2 Gene

HapMap Linkage Disequilibrium report
ISCA2
Human Gene Mutation Database (HGMD)
ISCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ISCA2 Gene

Disorders for ISCA2 Gene

Relevant External Links for ISCA2

Genetic Association Database (GAD)
ISCA2
Human Genome Epidemiology (HuGE) Navigator
ISCA2
genes like me logo Genes that share disorders with ISCA2: view

No data available for UniProtKB/Swiss-Prot for ISCA2 Gene

Publications for ISCA2 Gene

  1. The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation. (PMID: 22323289) Sheftel A.D. … Lill R. (Mol. Biol. Cell 2012) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for ISCA2 Gene

Sources for ISCA2 Gene

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