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ISCA2 Gene

protein-coding   GIFtS: 50
GCID: GC14P074960

Iron-Sulfur Cluster Assembly 2

(Previous names: HesB like domain containing 1, iron-sulfur cluster assembly...)
(Previous symbol: HBLD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Iron-Sulfur Cluster Assembly 21 2     Iron-Sulfur Cluster Assembly 2 Homolog (S. Cerevisiae)1
HBLD11 2 3     ISA22
HESB-Like Domain-Containing Protein 12 3     c14_55572
HesB Like Domain Containing 11     Iron-Sulfur Cluster Assembly 2 Homolog, Mitochondrial2

External Ids:    HGNC: 198571   Entrez Gene: 1229612   Ensembl: ENSG000001658987   OMIM: 6153175   UniProtKB: Q86U283   

Export aliases for ISCA2 gene to outside databases

Previous GC identifers: GC14P074031 GC14P055128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ISCA2 Gene:
The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded
protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Dec 2012)

GeneCards Summary for ISCA2 Gene:
ISCA2 (iron-sulfur cluster assembly 2) is a protein-coding gene. Diseases associated with ISCA2 include hemophilia, and tuberculosis. GO annotations related to this gene include iron-sulfur cluster binding and structural molecule activity.

UniProtKB/Swiss-Prot: ISCA2_HUMAN, Q86U28
Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster
assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISCA2 gene promoter:
         GR   Elk-1   AP-1   NRSF form 1   HTF   NRSF form 2   POU2F1   FOXO4   POU2F1a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISCA2 promoter sequence
   Search Chromatin IP Primers for ISCA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISCA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.2

ISCA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISCA2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P074960:  view genomic region     (about GC identifiers)

Start:
74,960,423 bp from pter      End:
74,963,809 bp from pter
Size:
3,387 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ISCA2_HUMAN, Q86U28 (See protein sequence)
Recommended Name: Iron-sulfur cluster assembly 2 homolog, mitochondrial precursor  
Size: 154 amino acids; 16476 Da
Sequence caution: Sequence=CAD62580.1; Type=Erroneous initiation;
Secondary accessions: A6NFF1 A8K3W3 Q8IYZ0 Q96BB2

Explore the universe of human proteins at neXtProt for ISCA2: NX_Q86U28

Explore proteomics data for ISCA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ISCA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001258936.1  NP_919255.2  

    ENSEMBL proteins: 
     ENSP00000452007   ENSP00000298818   ENSP00000450523  

    ISCA2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ISCA2

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    ISCA2 Assay Products:

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    Cloud-Clone Corp. ELISAs for ISCA2
    Cloud-Clone Corp. CLIAs for ISCA2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016092 FeS_cluster_insertion
     IPR017870 FeS_cluster_insertion_CS
     IPR000361 FeS_biogenesis

    Graphical View of Domain Structure for InterPro Entry Q86U28

    ProtoNet protein and cluster: Q86U28

    1 Blocks protein domain: IPB000361 Protein of unknown function

    UniProtKB/Swiss-Prot: ISCA2_HUMAN, Q86U28
    Similarity: Belongs to the HesB/IscA family


    ISCA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISCA2_HUMAN, Q86U28
    Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster
    assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0046872metal ion binding IEA--
    GO:0051536iron-sulfur cluster binding IEA--
         
    ISCA2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISCA2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISCA2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISCA2

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate ISCA2:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidISCA2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ISCA2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ISCA2 (NM_194279)
    Sino Biological Human cDNA Clone for ISCA2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISCA2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISCA2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISCA2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ISCA2_HUMAN, Q86U28: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    ISCA2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISCA2
    Interactions:

        Search GeneGlobe Interaction Network for ISCA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ISCA2 (Q86U283 ENSP000002988184) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C12orf4Q9NQ893I2D: score=5 
    RPS6ENSP000003697574STRING: ENSP00000369757
    CPVLENSP000002653944STRING: ENSP00000265394
    RPS7ENSP000003390954STRING: ENSP00000339095
    GLRX2ENSP000003564104STRING: ENSP00000356410
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016226iron-sulfur cluster assembly IEA--

    ISCA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISCA2

    1 HMDB Compound for ISCA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ISCA2 gene (2 alternative transcripts): 
    NM_001272007.1  NM_194279.3  

    Unigene Cluster for ISCA2:

    Iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
    Hs.291079  [show with all ESTs]
    Unigene Representative Sequence: BQ224801
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556816(uc001xpz.2) ENST00000298818 ENST00000554924 ENST00000555139

    miRNA
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    Block miRNA regulation of human, mouse, rat ISCA2 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate ISCA2:
    hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidISCA2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ISCA2
    Predesigned siRNA for gene silencing in human, mouse, rat ISCA2
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    GenScript: all cDNA clones in your preferred vector: ISCA2 (NM_194279)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISCA2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ISCA2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ISCA2
      QuantiTect SYBR Green Assays in human, mouse, rat ISCA2
      QuantiFast Probe-based Assays in human, mouse, rat ISCA2

    Additional mRNA sequence: 

    AK290728.1 BC015771.1 BC032893.2 BX248252.1 

    6 DOTS entries:

    DT.100032518  DT.100794204  DT.313533  DT.100835373  DT.120749213  DT.86842811 

    Selected AceView cDNA sequences (see all 136):

    AA357062 AI474662 CD671524 AI301334 CB114594 AI797561 AI658543 BU845302 
    BU630812 BM761557 BU631516 BX248252 AI224470 BQ068588 AI080185 AW572948 
    BU846230 AW241976 AI199880 AW472948 BQ017457 CB114595 C02486 BM142281 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ISCA2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for ISCA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ISCA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTAAAAT
    ISCA2 Expression
    About this image

    ISCA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISCA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.291079
        Custom PCR Arrays for ISCA2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISCA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ISCA2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isca21 , 5 iron-sulfur cluster assembly 2 homolog (S. cerevisiae)1, 5 85.71(n)1
    83.77(a)1
      12 (39.38 cM)5
    743161  NM_028863.11  NP_083139.11 
     847732705 
    chicken
    (Gallus gallus)
    Aves ISCA21 iron-sulfur cluster assembly 2 homolog (S. cerevisiae) 68.21(n)
    70.2(a)
      423352  XM_421267.4  XP_421267.4 
    lizard
    (Anolis carolinensis)
    Reptilia ISCA26
    iron-sulfur cluster assembly 2
    70(a)
    1 ↔ 1
    1(23147440-23155515)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia isca21 iron-sulfur cluster assembly 2 58.82(n)
    62.5(a)
      100135112  XM_004917052.1  XP_004917109.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001504381 iron-sulfur cluster assembly 2 homolog, mitochondrial-like 66.98(n)
    68.52(a)
      100150438  XM_003200369.2  XP_003200417.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136231 CG13623 57.14(n)
    53.78(a)
      42926  NM_001275991.1  NP_001262920.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y54G11A.91 CELE_Y54G11A.9 55.2(n)
    50.4(a)
      175088  NM_064580.3  NP_496981.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISA26
    Protein required for maturation of mitochondrial [...
    25(a)
    1 ↔ 1
    XVI(682220-682777) YPR067W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G039051 AT5G03905 48.81(n)
    51.43(a)
      830270  NM_120472.3  NP_568130.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03697001 Os08g0369700 53.43(n)
    51.47(a)
      4345405  NM_001068193.2  NP_001061658.2 


    ENSEMBL Gene Tree for ISCA2 (if available)
    TreeFam Gene Tree for ISCA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ISCA2 gene
    1 SIMAP similar gene for ISCA2 using alignment to 3 protein entries:     ISCA2_HUMAN (see all proteins):
    ISCA1

    ISCA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ISCA2
    PGOHUM00000246300


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    9 SNPs for ISCA2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840104371,2
    C--74962174(+) CACCCA/TGCCAG 2 -- ut310--------
    rs49032311,2
    C,F,A,H--74962233(+) TTCCTA/GTTTGA 2 -- ut3128Minor allele frequency- G:0.40NA NS EA WA CSA 2495
    rs1871945211,2
    --74962267(+) ATGCTC/TGTGGA 2 -- ut310--------
    rs111590861,2
    C,F,A,H--74962275(+) GGATCT/CGCTAT 2 -- ds500127Minor allele frequency- C:0.24NA NS EA CSA WA 2909
    rs1913254231,2
    --74962341(+) TAGTGA/CATTAT 2 -- ds50010--------
    rs1428271331,2
    C--74962501(+) ATAGGC/TAATAG 2 -- ds50010--------
    rs37597451,2
    C,F,A,H--74962670(-) GGTCAG/ACAAAT 2 -- ds500120Minor allele frequency- A:0.24NS EA NA CSA WA 2340
    rs1837172441,2
    --74962748(+) TGTGTA/GGGTGT 2 -- ds50010--------
    rs3720149121,2
    ----74962730(+) CTAGTA/GATTAA 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ISCA2 (74960423 - 74963809 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ISCA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902099CNV Loss21882294
    nsv832829CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISCA2
    DNA2.0 Custom Variant and Variant Library Synthesis for ISCA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615317    OMIM disorders: --

    3 diseases for ISCA2:    
    About MalaCards
    hemophilia    tuberculosis    malaria


    ISCA2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ISCA2
    Human Genome Epidemiology (HuGE) Navigator: ISCA2 (4 documents)

    Export disorders for ISCA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISCA2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ISCA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation. (PubMed id 22323289)1, 2, 3 Sheftel A.D....Lill R. (Mol. Biol. Cell 2012)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 122961 HGNC: 19857 AceView: HBLD1 Ensembl:ENSG00000165898 euGenes: HUgn122961
    ECgene: ISCA2 H-InvDB: ISCA2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ISCA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISCA2 gene:
    Search GeneIP for patents involving ISCA2

    GeneCards and IP:
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