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ISCA1 Gene

protein-coding   GIFtS: 53
GCID: GC09M088879

Iron-Sulfur Cluster Assembly 1

(Previous names: HESB like domain containing 2, iron-sulfur cluster assembly...)
(Previous symbol: HBLD2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Iron-Sulfur Cluster Assembly 11 2     Iron-Sulfur Cluster Assembly 1 Homolog (S. Cerevisiae)1
HBLD21 2 3 5     ISA12
HESB Like Domain Containing 21 2     Iron Sulfur Assembly Protein IscA2
Iron-Sulfur Assembly Protein IscA2 3     Iron-Sulfur Cluster Assembly 1 Homolog, Mitochondrial2
hIscA2 3     HISCA5
HESB-Like Domain-Containing Protein 22 3     

External Ids:    HGNC: 286601   Entrez Gene: 816892   Ensembl: ENSG000001350707   OMIM: 6110065   UniProtKB: Q9BUE63   

Export aliases for ISCA1 gene to outside databases

Previous GC identifers: GC09M088070 GC09M058702


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ISCA1 Gene:
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a
role in electron-transfer reactions (Cozar-Castellano et al., 2004 (PubMed 15262227)).(supplied by OMIM, Mar
2008)

GeneCards Summary for ISCA1 Gene:
ISCA1 (iron-sulfur cluster assembly 1) is a protein-coding gene. Diseases associated with ISCA1 include choroiditis, and malaria. GO annotations related to this gene include iron-sulfur cluster binding and structural molecule activity.

UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6
Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster
assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly

Gene Wiki entry for ISCA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the ISCA1 gene promoter:
         HOXA9   HOXA9B   NF-1/L   NF-1   AML1a   Lmo2   HEN1   FOXO4   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidISCA1 promoter sequence
   Search Chromatin IP Primers for ISCA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ISCA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.33   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q22.1

ISCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISCA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M088879:  view genomic region     (about GC identifiers)

Start:
88,879,461 bp from pter      End:
88,897,676 bp from pter
Size:
18,216 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6 (See protein sequence)
Recommended Name: Iron-sulfur cluster assembly 1 homolog, mitochondrial precursor  
Size: 129 amino acids; 14179 Da
Sequence caution: Sequence=AAG59854.1; Type=Erroneous initiation; Sequence=CAD39021.1; Type=Erroneous initiation;
Secondary accessions: B3KP34 Q8ND75 Q9BZR2

Explore the universe of human proteins at neXtProt for ISCA1: NX_Q9BUE6

Explore proteomics data for ISCA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ISCA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112202.2  
    ENSEMBL proteins: 
     ENSP00000365159   ENSP00000339003   ENSP00000365157   ENSP00000409332  

    ISCA1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ISCA1

    ISCA1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for ISCA1

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    Cloud-Clone Corp. ELISAs for ISCA1
    Cloud-Clone Corp. CLIAs for ISCA1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016092 FeS_cluster_insertion
     IPR017870 FeS_cluster_insertion_CS
     IPR000361 FeS_biogenesis

    Graphical View of Domain Structure for InterPro Entry Q9BUE6

    ProtoNet protein and cluster: Q9BUE6

    1 Blocks protein domain: IPB000361 Protein of unknown function

    UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6
    Similarity: Belongs to the HesB/IscA family


    ISCA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISCA1_HUMAN, Q9BUE6
    Function: Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster
    assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0046872metal ion binding IEA--
    GO:0051536iron-sulfur cluster binding IEA--
         
    ISCA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ISCA1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ISCA1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ISCA1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ISCA1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ISCA1:
    hsa-mir-181c-5p (MIRT047223)

    Block miRNA regulation of human, mouse, rat ISCA1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ISCA1:
    hsa-miR-182* hsa-miR-544b hsa-miR-92a-1* hsa-miR-3613-3p hsa-miR-542-3p hsa-miR-1299 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidISCA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ISCA1
    Predesigned siRNA for gene silencing in human, mouse, rat ISCA1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ISCA1 (NM_030940)
    Sino Biological Human cDNA Clone for ISCA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISCA1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ISCA1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISCA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ISCA1_HUMAN, Q9BUE6: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    ISCA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ISCA1
    Interactions:

        Search GeneGlobe Interaction Network for ISCA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ISCA1 (Q9BUE62, 3 ENSP000003651594) via UniProtKB, MINT, STRING, and/or I2D (see all 279)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    EIF3LQ9Y2623I2D: score=5 
    RAE1P784063I2D: score=5 
    RPS20P608663I2D: score=5 
    ZNF800Q2TB103I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016226iron-sulfur cluster assembly IEA--

    ISCA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ISCA1

    1 HMDB Compound for ISCA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ISCA1 gene: 
    NM_030940.3  

    Unigene Cluster for ISCA1:

    Iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
    Hs.449291  [show with all ESTs]
    Unigene Representative Sequence: NM_030940
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375991(uc004aop.3) ENST00000311534 ENST00000326094 ENST00000452279

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ISCA1 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate ISCA1:
    hsa-miR-182* hsa-miR-544b hsa-miR-92a-1* hsa-miR-3613-3p hsa-miR-542-3p hsa-miR-1299 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidISCA1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ISCA1
    Predesigned siRNA for gene silencing in human, mouse, rat ISCA1
    Clone
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    OriGene ORF clones in mouse, rat for ISCA1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ISCA1 (NM_030940)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ISCA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ISCA1
    Primer
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    OriGene qPCR primer pairs and template standards for ISCA1
    OriGene qSTAR qPCR primer pairs in human, mouse for ISCA1
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat ISCA1
      QuantiTect SYBR Green Assays in human, mouse, rat ISCA1
      QuantiFast Probe-based Assays in human, mouse, rat ISCA1

    Additional mRNA sequence: 

    AF038186.1 AF284752.1 AK055643.1 AK225937.1 AK296093.1 AL834356.1 AY015642.1 BC002675.2 
    BC053900.1 BC071621.1 

    16 DOTS entries:

    DT.100692121  DT.100786531  DT.40268978  DT.121208267  DT.121208295  DT.100786525  DT.120805290  DT.121208257 
    DT.100681414  DT.91738680  DT.91743709  DT.91852780  DT.91983379  DT.121208229  DT.40107881  DT.91809974 

    Selected AceView cDNA sequences (see all 307):

    BM910106 AA781832 CB215892 BQ447222 AA805549 AW069469 AY015642 BM127834 
    BI521583 AI633528 BU150683 BE891206 BM452443 BG259912 CR616889 CR604050 
    AI344016 CA391257 BM909090 BP337954 AA742171 NM_030940 AW105378 BU678966 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ISCA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for ISCA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ISCA1 expression in normal human tissues (normalized intensities)      ISCA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTGTATC
    ISCA1 Expression
    About this image


    ISCA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Fourth Ventricle
    ISCA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ISCA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.449291

    UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6
    Tissue specificity: Detected in cerebellum, kidney and heart

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ISCA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ISCA1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Isca11 , 5 iron-sulfur cluster assembly 1 homolog (S. cerevisiae)1, 5 87.08(n)1
    96.9(a)1
      13 (31.88 cM)5
    690461  NM_026921.41  NP_081197.11 
     597554095 
    chicken
    (Gallus gallus)
    Aves ISCA11 iron-sulfur cluster assembly 1 homolog (S. cerevisiae) 83.46(n)
    93.02(a)
      427463  NM_001271936.1  NP_001258865.1 
    lizard
    (Anolis carolinensis)
    Reptilia ISCA16
    iron-sulfur cluster assembly 1
    91(a)
    1 ↔ 1
    2(41747560-41759185)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96462 Xenopus laevis transcribed sequences 77.99(n)    BJ615813.1 
    zebrafish
    (Danio rerio)
    Actinopterygii isca11 iron-sulfur cluster assembly 1 70.28(n)
    84.5(a)
      573999  NM_001025178.2  NP_001020349.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G01361 lethal (1) G0136 64.48(n)
    77.87(a)
      32513  NM_132834.2  NP_573062.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y39B6A.31 CELE_Y39B6A.3 59.88(n)
    67.26(a)
      180262  NM_171606.4  NP_741696.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISA16
    Protein required for maturation of mitochondrial [...
    24(a)
    1 ↔ 1
    XII(87403-88155) YLL027W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G167101 AT2G16710 50.81(n)
    50.81(a)
      816172  NM_001202607.1  NP_001189536.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01058001 Os01g0105800 55.56(n)
    54.47(a)
      9272545  NM_001185190.1  NP_001172119.1 


    ENSEMBL Gene Tree for ISCA1 (if available)
    TreeFam Gene Tree for ISCA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ISCA1 gene
    1 SIMAP similar gene for ISCA1 using alignment to 4 protein entries:     ISCA1_HUMAN (see all proteins):
    ISCA2

    ISCA1 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ISCA1 (see all 11)
    PGOHUM00000246758 PGOHUM00000248948 PGOHUM00000237440 PGOHUM00000234196 PGOHUM00000234234


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ISCA1 (see all 353)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs625733691,2
    C--88878971(+) ACACTT/CACCAT 1 -- ds50013Minor allele frequency- C:0.10NA EA 242
    rs1380972971,2
    --88878988(+) CGATGC/GTCTTC 1 -- ds50010--------
    rs1411388941,2
    C--88878993(+) CTCTTC/TGCTGG 1 -- ds50010--------
    rs1501276061,2
    --88879081(+) AGTCAA/GTGCTC 1 -- ds50010--------
    rs1905811661,2
    --88879188(+) GCTCTC/TGTCCT 1 -- ds50010--------
    rs1829204771,2
    --88879213(+) CCTGCC/TTGGGG 1 -- ds50010--------
    rs1168358461,2
    F--88879241(+) GGGAAC/TAAGGA 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs10591441,2
    C,F,H--88879525(-) TGCAAT/CACTGT 1 -- ut31 ese39Minor allele frequency- C:0.41NA WA CSA 141
    rs1385929111,2
    --88879667(+) GCTACG/TTGAAT 1 -- ut310--------
    rs1493076881,2
    C--88879704(+) CATATA/GTATCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ISCA1 (88879461 - 88897676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ISCA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893536CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ISCA1
    DNA2.0 Custom Variant and Variant Library Synthesis for ISCA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611006    OMIM disorders: --

    2 diseases for ISCA1:    About MalaCards
    choroiditis    malaria


    ISCA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ISCA1
    Human Genome Epidemiology (HuGE) Navigator: ISCA1 (2 documents)

    Export disorders for ISCA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ISCA1 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with ISCA1)
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    1. hIscA: a protein implicated in the biogenesis of iron-sulfur clusters. (PubMed id 15262227)1, 2, 3, 9 Cozar-Castellano I.... Avila J. (Biochim. Biophys. Acta 2004)
    2. The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation. (PubMed id 22323289)1, 2, 3 Sheftel A.D....Lill R. (Mol. Biol. Cell 2012)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Frataxin directly stimulates mitochondrial cysteine desulfurase by exposing substrate-binding sites, and a mutant Fe-S cluster scaffold protein with frataxin-bypassing ability acts similarly. (PubMed id 24217246)1 Pandey A....Pain D. (J. Biol. Chem. 2013)
    8. Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1. (PubMed id 20302570)1 Lu J....Ding H. (Biochem. J. 2010)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)
    10. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. (PubMed id 19656490)1 Nilsson R....Mootha V.K. (Cell Metab. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81689 HGNC: 28660 AceView: HBLD2andC9orf153 Ensembl:ENSG00000135070 euGenes: HUgn81689
    ECgene: ISCA1 H-InvDB: ISCA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ISCA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ISCA1 gene:
    Search GeneIP for patents involving ISCA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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