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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ISCA1 Gene

protein-coding   GIFtS: 53
GCID: GC09M088879

Iron-Sulfur Cluster Assembly 1

(Previous names: HESB like domain containing 2, iron-sulfur cluster assembly...)
(Previous symbol: HBLD2)
  Search for ISCA1
at
MalaCards
 

Aliases
for ISCA1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Iron-Sulfur Cluster Assembly 11 2     Iron-Sulfur Cluster Assembly 1 Homolog (S. Cerevisiae)1
HBLD21 2 3 5     ISA12
HESB Like Domain Containing 21 2     RP11-507D14.22
Iron-Sulfur Assembly Protein IscA2 3     Iron Sulfur Assembly Protein IscA2
hIscA2 3     Iron-Sulfur Cluster Assembly 1 Homolog, Mitochondrial2
HESB-Like Domain-Containing Protein 22 3     HISCA5

External Ids:    HGNC: 286601   Entrez Gene: 816892   Ensembl: ENSG000001350707   OMIM: 6110065   UniProtKB: Q9BUE63   

Export aliases for ISCA1 gene to outside databases

Previous GC identifers: GC09M088070 GC09M058702


Summaries
for ISCA1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ISCA1 Gene:
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in
electron-transfer reactions (Cozar-Castellano et al., 2004 (PubMed 15262227)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ISCA1 Gene: 
ISCA1 (iron-sulfur cluster assembly 1) is a protein-coding gene. GO annotations related to this gene include iron-sulfur cluster binding and structural molecule activity.

UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6
Function: Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an
intermediate of Fe/S cluster assembly

Gene Wiki entry for ISCA1 Gene


Genomic Views
for ISCA1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ISCA1 gene promoter:
         HOXA9   HOXA9B   NF-1/L   NF-1   AML1a   Lmo2   HEN1   FOXO4   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ISCA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ISCA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ISCA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.33   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q22.1

ISCA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ISCA1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M088879:  view genomic region     (about GC identifiers)

Start:
 88,879,461 bp from pter      End:
 88,897,676 bp from pter
Size:
 18,216 bases      Orientation:
 minus strand

Proteins
for ISCA1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6 (See protein sequence)
Recommended Name: Iron-sulfur cluster assembly 1 homolog, mitochondrial precursor  
Size: 129 amino acids; 14179 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG59854.1; Type=Erroneous initiation; Sequence=CAD39021.1; Type=Erroneous initiation;
Secondary accessions: B3KP34 Q8ND75 Q9BZR2

Explore the universe of human proteins at neXtProt for ISCA1: NX_Q9BUE6

Explore proteomics data for ISCA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BUE6

    • ISCA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ISCA1 Protein Expression
    REFSEQ proteins: NP_112202.2  
    ENSEMBL proteins: 
     ENSP00000365159   ENSP00000339003   ENSP00000365157   ENSP00000409332  

    Human Recombinant Protein Products for ISCA1: 
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    Novus Biologicals ISCA1 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ISCA1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    ISCA1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ISCA1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 3 InterPro protein domains:
     IPR016092 FeS_cluster_insertion
     IPR017870 FeS_cluster_insertion_CS
     IPR000361 FeS_biogenesis

    Graphical View of Domain Structure for InterPro Entry Q9BUE6

    ProtoNet protein and cluster: Q9BUE6

    1 Blocks protein domain: IPB000361 Protein of unknown function

    UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6
    Similarity: Belongs to the HesB/IscA family


    ISCA1 for domains           About GeneDecksing


    Function
    for ISCA1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ISCA1_HUMAN, Q9BUE6
    Function: Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an
    intermediate of Fe/S cluster assembly

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IEA--
    GO:0046872metal ion binding IEA--
    GO:0051536iron-sulfur cluster binding IEA--
         
    ISCA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ISCA1:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ISCA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ISCA1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ISCA1
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ISCA1:
    hsa-miR-182* hsa-miR-544b hsa-miR-92a-1* hsa-miR-3613-3p hsa-miR-542-3p hsa-miR-1299 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: ISCA1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for ISCA1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ISCA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/256 Interacting proteins for ISCA1 (Q9BUE62, 3 ENSP000003651594) via UniProtKB, MINT, STRING, and/or I2D (see all 256)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    EIF3LQ9Y2623I2D: score=5 
    RAE1P784063I2D: score=5 
    RPS20P608663I2D: score=5 
    ZNF800Q2TB103I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016226iron-sulfur cluster assembly IEA--

    ISCA1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ISCA1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ISCA1

    1 HMDB Compound for ISCA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    IronArmco iron (see all 19)7439-89-6--

    Search CenterWatch for drugs/clinical trials and news about ISCA1

    Transcripts
    for ISCA1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ISCA1 gene: 
    NM_030940.3  

    Unigene Cluster for ISCA1:

    Iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
    Hs.449291  [show with all ESTs]
    Unigene Representative Sequence: NM_030940
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375991(uc004aop.3) ENST00000311534 ENST00000326094 ENST00000452279

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate ISCA1:
    hsa-miR-182* hsa-miR-544b hsa-miR-92a-1* hsa-miR-3613-3p hsa-miR-542-3p hsa-miR-1299 hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmid: ISCA1 3' UTR sequence
    Inhib. RNA
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ISCA1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ISCA1

    Additional mRNA sequence: 

    AF038186.1 AF284752.1 AK055643.1 AK225937.1 AK296093.1 AL834356.1 AY015642.1 BC002675.2 
    BC053900.1 BC071621.1 

    16 DOTS entries:

    DT.100692121  DT.100786531  DT.40268978  DT.121208267  DT.121208295  DT.100786525  DT.120805290  DT.121208257 
    DT.100681414  DT.91738680  DT.91743709  DT.91852780  DT.91983379  DT.121208229  DT.40107881  DT.91809974 

    24/307 AceView cDNA sequences (see all 307):

    AA781832 BQ271894 AA419604 BM452443 CB215892 AY015642 CK903486 AW163173 
    BM710874 AL045685 AW469014 BU681494 AI436792 AW105378 BX370479 AU280763 
    AW069469 H45510 BG259912 BM127834 AI344016 CR616889 BQ447222 AA805549 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ISCA1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for ISCA1

    Expression
    for ISCA1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ISCA1 expression in normal human tissues (normalized intensities)      ISCA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTGTATC
    ISCA1 Expression
    About this image


    ISCA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Fourth Ventricle

    See ISCA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ISCA1

    SOURCE GeneReport for Unigene cluster: Hs.449291

    UniProtKB/Swiss-Prot: ISCA1_HUMAN, Q9BUE6
    Tissue specificity: Detected in cerebellum, kidney and heart

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    In Situ
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    Orthologs
    for ISCA1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ISCA1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Isca11 , 5 iron-sulfur cluster assembly 1 homolog (S. cerevisiae)1, 5 87.08(n)1
    96.9(a)1    		   13 (31.88 cM)5
    690461  NM_026921.41  NP_081197.11 
     597554095 
    chicken
    (Gallus gallus)    		 Aves ZCCHC61 zinc finger, CCHC domain containing 6 83.46(n)
    93.02(a)    		   427463  XM_003643007.1  XP_003643055.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ISCA16
    		 Uncharacterized protein
    		 91(a)
    		 1 ↔ 1
    		 2(41747560-41759185)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.96462 Xenopus laevis transcribed sequences 77.99(n)    BJ615813.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii isca11 iron-sulfur cluster assembly 1 70.28(n)
    84.5(a)    		   573999  NM_001025178.1  NP_001020349.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta l(1)G01361 lethal (1) G0136 64.48(n)
    77.87(a)    		   32513  NM_132834.1  NP_573062.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_Y39B6A.31 Protein Y39B6A.3 56.94(n)
    62.5(a)    		   180262  NM_001129566.1  NP_001123038.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ISA11 Isa1p 58.48(n)
    51.75(a)    		   850632   NP_013073.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G167101 Iron-sulfur assembly protein IscA-like 1 50.81(n)
    50.81(a)    		   816172  NM_001202607.1  NP_001189536.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g01058001 hypothetical protein 54.13(n)
    52.8(a)    		   9272545  NM_001185190.1  NP_001172119.1 


    ENSEMBL Gene Tree for ISCA1 (if available)
    TreeFam Gene Tree for ISCA1 (if available)

    Paralogs
    for ISCA1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ISCA1 gene
    1 SIMAP similar gene for ISCA1 using alignment to 4 protein entries:     ISCA1_HUMAN (see all proteins):
    ISCA2

    ISCA1 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for ISCA1 (see all 11)
    PGOHUM00000246758 PGOHUM00000248948 PGOHUM00000237440 PGOHUM00000234196 PGOHUM00000234234


    Genomic Variants
    for ISCA1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/353 SNPs in ISCA1 are shown (see all 353)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs625733691,2
    		C--88878971(+) ACACTT/CACCAT 1 -- ds50013Minor allele frequency- C:0.10NA EA 242
    rs1380972971,2
    		--88878988(+) CGATGC/GTCTTC 1 -- ds50010--------
    rs1411388941,2
    		C--88878993(+) CTCTTC/TGCTGG 1 -- ds50010--------
    rs1501276061,2
    		--88879081(+) AGTCAA/GTGCTC 1 -- ds50010--------
    rs1905811661,2
    		--88879188(+) GCTCTC/TGTCCT 1 -- ds50010--------
    rs1829204771,2
    		--88879213(+) CCTGCC/TTGGGG 1 -- ds50010--------
    rs1168358461,2
    		F--88879241(+) GGGAAC/TAAGGA 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs10591441,2
    		C,F,H--88879525(-) TGCAAT/CACTGT 1 -- ut31 ese39Minor allele frequency- C:0.41NA WA CSA 141
    rs1385929111,2
    		--88879667(+) GCTACG/TTGAAT 1 -- ut310--------
    rs1493076881,2
    		C--88879704(+) CATATA/GTATCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ISCA1 (88879461 - 88897676 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ISCA1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893536CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ISCA1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ISCA1 for disorders           About MalaCards

    ISCA1 for disorders           About GeneDecksing

    OMIM gene information: 611006    OMIM disorders: --

    Genetic Association Database (GAD): ISCA1
    Human Genome Epidemiology (HuGE) Navigator: ISCA1 (2 documents)

    Export disorders for ISCA1 gene to outside databases

    Publications
    for ISCA1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ISCA1 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with ISCA1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. hIscA: a protein implicated in the biogenesis of iron-sulfur clusters. (PubMed id 15262227)1, 2, 3, 9 Cozar-Castellano I.... Avila J. (2004)
    2. The human mitochondrial ISCA1, ISCA2, and IBA57 protei ns are required for [4Fe-4S] protein maturation. (PubMed id 22323289)1, 3 Sheftel A.D....Lill R. (2012)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Iron-binding activity of human iron-sulfur cluster as sembly protein hIscA1. (PubMed id 20302570)1 Lu J....Ding H. (2010)
    8. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    9. Discovery of genes essential for heme biosynthesis th rough large-scale gene expression analysis. (PubMed id 19656490)1 Nilsson R....Mootha V.K. (2009)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    External Searches for ISCA1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ISCA1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81689 HGNC: 28660 AceView: HBLD2andC9orf153 Ensembl:ENSG00000135070 euGenes: HUgn81689
    ECgene: ISCA1 H-InvDB: ISCA1

    Other Databases showing ISCA1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ISCA1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ISCA1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ISCA1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ISCA1 gene:
    Search GeneIP for patents involving ISCA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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