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Aliases for IRX6 Gene

Aliases for IRX6 Gene

  • Iroquois Homeobox 6 2 3
  • Iroquois Homeobox Protein 6 2 3 4
  • IRX7 3 4 6
  • Iroquois Homeobox Protein 7 2 3
  • Homeodomain Protein IRXB3 3 4
  • IRXB3 3 4
  • Iroquois-Class Homeodomain Protein IRX-6 3
  • IRX-3 3

External Ids for IRX6 Gene

Previous Symbols for IRX6 Gene

  • IRX7

Summaries for IRX6 Gene

GeneCards Summary for IRX6 Gene

IRX6 (Iroquois Homeobox 6) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IRX3.

Gene Wiki entry for IRX6 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX6 Gene

Genomics for IRX6 Gene

Genomic Location for IRX6 Gene

Start:
55,323,760 bp from pter
End:
55,330,760 bp from pter
Size:
7,001 bases
Orientation:
Plus strand

Genomic View for IRX6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX6 Gene

Regulatory Elements for IRX6 Gene

Proteins for IRX6 Gene

  • Protein details for IRX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78412-IRX6_HUMAN
    Recommended name:
    Iroquois-class homeodomain protein IRX-6
    Protein Accession:
    P78412
    Secondary Accessions:
    • B2RN06
    • Q7Z2K0

    Protein attributes for IRX6 Gene

    Size:
    446 amino acids
    Molecular mass:
    48240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX6 Gene

Proteomics data for IRX6 Gene at MOPED

Post-translational modifications for IRX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX6 Gene

Domains for IRX6 Gene

Gene Families for IRX6 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Suggested Antigen Peptide Sequences for IRX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78412

UniProtKB/Swiss-Prot:

IRX6_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P78412
Family:
  • Belongs to the TALE/IRO homeobox family.:
    • P78412
genes like me logo Genes that share domains with IRX6: view

Function for IRX6 Gene

Gene Ontology (GO) - Molecular Function for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX6: view

Phenotypes for IRX6 Gene

genes like me logo Genes that share phenotypes with IRX6: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IRX6 Gene

Localization for IRX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRX6 Gene COMPARTMENTS Subcellular localization image for IRX6 gene
Compartment Confidence
nucleus 4
cytosol 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX6: view

Pathways for IRX6 Gene

SuperPathways for IRX6 Gene

No Data Available

Interacting Proteins for IRX6 Gene

Gene Ontology (GO) - Biological Process for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with IRX6: view

No data available for Pathways by source for IRX6 Gene

Transcripts for IRX6 Gene

mRNA/cDNA for IRX6 Gene

Unigene Clusters for IRX6 Gene

Iroquois homeobox 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRX6 Gene

No ASD Table

Relevant External Links for IRX6 Gene

GeneLoc Exon Structure for
IRX6
ECgene alternative splicing isoforms for
IRX6

Expression for IRX6 Gene

mRNA expression in normal human tissues for IRX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (7.2), Skin - Sun Exposed (Lower leg) (7.1), Adipose - Visceral (Omentum) (7.1), Heart - Left Ventricle (6.6), and Adipose - Subcutaneous (6.1).

SOURCE GeneReport for Unigene cluster for IRX6 Gene Hs.369907

genes like me logo Genes that share expressions with IRX6: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for IRX6 Gene

Orthologs for IRX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRX6 35
  • 98.35 (n)
  • 97.98 (a)
IRX6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRX6 35
  • 85.33 (n)
  • 84.2 (a)
IRX6 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRX6 35
  • 84.5 (n)
  • 80.59 (a)
IRX6 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irx6 35
  • 79.35 (n)
  • 75.4 (a)
Irx6 16
Irx6 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRX6 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRX6 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irx6 35
  • 78.86 (n)
  • 76.59 (a)
chicken
(Gallus gallus)
Aves IRX6 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irx6 35
  • 53.89 (n)
  • 47.46 (a)
zebrafish
(Danio rerio)
Actinopterygii irx6a 35
  • 62.56 (n)
  • 58.15 (a)
irx6a 36
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ara 36
  • 18 (a)
ManyToMany
caup 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 4 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
Species with no ortholog for IRX6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX6 Gene

ENSEMBL:
Gene Tree for IRX6 (if available)
TreeFam:
Gene Tree for IRX6 (if available)

Paralogs for IRX6 Gene

Paralogs for IRX6 Gene

Selected SIMAP similar genes for IRX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX6: view

Variants for IRX6 Gene

Sequence variations from dbSNP and Humsavar for IRX6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs31074 -- 55,323,258(+) TATAA(A/C)GCGCG upstream-variant-2KB
rs31075 -- 55,323,326(+) TGGAT(C/T)CCTGC upstream-variant-2KB
rs31076 -- 55,323,549(+) CTGCC(A/G)CCGCC upstream-variant-2KB
rs31077 -- 55,323,822(+) CCAGG(A/G)ATCTT upstream-variant-2KB
rs31078 -- 55,325,214(+) TGATC(A/T)TCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRX6 Gene

Variant ID Type Subtype PubMed ID
nsv833239 CNV Gain 17160897

Relevant External Links for IRX6 Gene

HapMap Linkage Disequilibrium report
IRX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX6 Gene

Disorders for IRX6 Gene

(1) University of Copenhagen DISEASES for IRX6 Gene

genes like me logo Genes that share disorders with IRX6: view

No data available for UniProtKB/Swiss-Prot for IRX6 Gene

Publications for IRX6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Irx3 is differentially up-regulated in female gonads during sex determination. (PMID: 15963769) Jorgensen J.S. … Gao L. (Gene Expr. Patterns 2005) 23
  5. Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort. (PMID: 17556197) Koopmann T.T. … Bezzina C.R. (Heart Rhythm 2007) 23

Products for IRX6 Gene

Sources for IRX6 Gene

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