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IRX6 Gene

protein-coding   GIFtS: 46
GCID: GC16P055357

Iroquois Homeobox 6

(Previous names: iroquois homeobox protein 7, iroquois homeobox protein 6)
(Previous symbol: IRX7)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Iroquois Homeobox 61 2     Homeodomain Protein IRXB32 3
IRX71 2 3 5     IRXB32 3
Iroquois Homeobox Protein 61 2 3     IRX-32
Iroquois Homeobox Protein 71 2     Iroquois-Class Homeodomain Protein IRX-62

External Ids:    HGNC: 146751   Entrez Gene: 791902   Ensembl: ENSG000001593877   OMIM: 6061965   UniProtKB: P784123   

Export aliases for IRX6 gene to outside databases

Previous GC identifers: GC16M055413 GC16P055096 GC16P055137 GC16P055136 GC16P053915 GC16P041244


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IRX6 Gene:
IRX6 (iroquois homeobox 6) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRX1.

Gene Wiki entry for IRX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRX6 gene promoter:
         Bach1   HFH-3   POU3F1   AP-2gamma   FOXL1   FOXI1   SRY   Nkx6-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRX6 promoter sequence
   Search Chromatin IP Primers for IRX6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

IRX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055357:  view genomic region     (about GC identifiers)

Start:
55,357,672 bp from pter      End:
55,364,672 bp from pter
Size:
7,001 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IRX6_HUMAN, P78412 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-6  
Size: 446 amino acids; 48240 Da
Secondary accessions: B2RN06 Q7Z2K0

Explore the universe of human proteins at neXtProt for IRX6: NX_P78412

Explore proteomics data for IRX6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRX6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077311.2  
    ENSEMBL proteins: 
     ENSP00000290552  

    IRX6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for IRX6

     
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    antibodies-online proteins for IRX6 (5 products) 

     
    antibodies-online peptides for IRX6

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    antibodies-online antibodies for IRX6 (27 products) 

    IRX6 Assay Products:

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    Cloud-Clone Corp. ELISAs for IRX6
    Cloud-Clone Corp. CLIAs for IRX6
    Search eBioscience for ELISAs for IRX6 
    antibodies-online kits for IRX6 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    5 InterPro protein domains:
     IPR003893 Iroquois_homeo
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78412

    ProtoNet protein and cluster: P78412

    1 Blocks protein domain: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX6_HUMAN, P78412
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with IRX6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with IRX6           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irx6):
     nervous system  vision/eye 

    Find genes that share phenotypes with IRX6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for IRX6

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat IRX6 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IRX6:
    hsa-miR-1197 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-520g hsa-miR-1253 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIRX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRX6
    Predesigned siRNA for gene silencing in human, mouse, rat IRX6

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for IRX6

    Clone
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    OriGene clones in human, mouse for IRX6 (see all 5)
    OriGene ORF clones in mouse, rat for IRX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRX6 (NM_024335)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for IRX6 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRX6_HUMAN, P78412: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1
    golgi apparatus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with IRX6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IRX6
    Interactions:

        Search GeneGlobe Interaction Network for IRX6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for IRX6 (ENSP000002905524) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MTX2ENSP000002494424STRING: ENSP00000249442
    LFNGENSP000002227254STRING: ENSP00000222725
    MFNGENSP000003494904STRING: ENSP00000349490
    RFNGENSP000003079714STRING: ENSP00000307971
    NOTCH1ENSP000002775414STRING: ENSP00000277541
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with IRX6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRX6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRX6 gene: 
    NM_024335.2  

    Unigene Cluster for IRX6:

    Iroquois homeobox 6
    Hs.369907  [show with all ESTs]
    Unigene Representative Sequence: AK125053
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290552(uc002ehx.3 uc002ehy.3) ENST00000558315(uc010ccb.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRX6 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate IRX6:
    hsa-miR-1197 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-520g hsa-miR-1253 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIRX6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IRX6
    Predesigned siRNA for gene silencing in human, mouse, rat IRX6
    Clone
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    OriGene clones in human, mouse for IRX6 (see all 5)
    OriGene ORF clones in mouse, rat for IRX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRX6 (NM_024335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRX6
      QuantiTect SYBR Green Assays in human, mouse, rat IRX6
      QuantiFast Probe-based Assays in human, mouse, rat IRX6

    Additional mRNA sequence: 

    AK125053.1 AK309149.1 AY335937.1 BC136573.1 BC136576.1 

    1 DOTS entry:

    DT.101980181 

    22 AceView cDNA sequences:

    BM724662 AI820799 AI821795 BM698030 AI792142 AK125053 NM_024335 AI185773 
    BM667197 AY335937 BM929891 AI263887 AI792465 AW449920 BU741332 BG739786 
    BX114798 AW149016 AI191445 AJ707304 U90305 BF204113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRX6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGGAGAAA
    IRX6 Expression
    About this image


    IRX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Type3a Off Cone Bipolar Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Type3a Off Cone Bipolar Cells Inner Nuclear Layer
    IRX6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRX6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369907
        Custom PCR Arrays for IRX6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IRX6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irx61 , 5 Iroquois related homeobox 6 (Drosophila)1, 5 79.35(n)1
    75.4(a)1
      8 (44.99 cM)5
    643791  NM_022428.21  NP_071873.21 
     926742895 
    chicken
    (Gallus gallus)
    Aves IRX66
    iroquois homeobox 6
    70(a)
    1 ↔ 1
    11(3356406-3358310)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia irx61 iroquois homeobox 6 53.89(n)
    47.46(a)
      100486749  XM_002939227.1  XP_002939273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii irx6a1 iroquois homeobox protein 6a 62.56(n)
    58.15(a)
      474317  NM_001023575.1  NP_001018869.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta caup6
    ara6
    araucan
    19(a)
    18(a)
    many ↔ many
    many ↔ many
    3L(12602731-12614898)
    3L(12573772-12589118)


    ENSEMBL Gene Tree for IRX6 (if available)
    TreeFam Gene Tree for IRX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRX6 gene
    IRX12  IRX32  IRX52  MKX2  IRX22  IRX42  
    3 SIMAP similar genes for IRX6 using alignment to 1 protein entry:     IRX6_HUMAN:
    TGIF1    IRX4    IRX1

    Find genes that share paralogs with IRX6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRX6 (see all 294)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384560301,2
    C--55356574(+) ACTTT-/AAAAAA 1 -- us2k10--------
    rs1878204911,2
    --55356601(+) CCAAGA/CTGCAA 1 -- us2k10--------
    rs47845231,2
    C,F,A,H--55356697(+) AGGACT/CATAAT 1 -- us2k123Minor allele frequency- C:0.45NS EA NA WA CSA 2345
    rs1435405111,2
    --55356707(+) TTCTTC/TTTCTA 1 -- us2k10--------
    rs1467907151,2
    --55356809(+) GAGCTC/TGTCCT 1 -- us2k10--------
    rs1929056931,2
    --55356830(+) ATCTCC/TTAAGC 1 -- us2k10--------
    rs1852798091,2
    --55356885(+) AGAATG/TTGTTT 1 -- us2k10--------
    rs1901743561,2
    --55357026(+) GAGCCA/GTTGCT 1 -- us2k10--------
    rs310741,2
    C,F,A,H--55357170(+) TATAAA/CGCGCG 1 -- us2k1 tfbs325Minor allele frequency- C:0.36NS EA NA WA CSA 2708
    rs310751,2
    C,F,A,H--55357238(+) TGGATT/CCCTGC 1 -- us2k124Minor allele frequency- C:0.36NS EA NA WA CSA 2532

    HapMap Linkage Disequilibrium report for IRX6 (55357672 - 55364672 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IRX6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833239CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRX6
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606196    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for IRX6:
    Astigmatism

    Find genes that share disorders with IRX6           About GenesLikeMe


    Export disorders for IRX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRX6 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with IRX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PubMed id 11435706)1 Ogura K.... Ogura T. (Cytogenet. Cell Genet. 2001)
    6. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1 Lewis M.T.... Daniel C.W. (Cell Tissue Res. 1999)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    8. (PubMed id )2 
    9. Irx3 is differentially up-regulated in female gonads during sex determination. (PubMed id 15963769)9 Jorgensen J.S. and Gao L. (Gene Expr. Patterns 2005)
    10. Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes. (PubMed id 19121738)9 Shih B....Bayat A. (J Hand Surg Am 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79190 HGNC: 14675 AceView: IRX6 Ensembl:ENSG00000159387 euGenes: HUgn79190
    ECgene: IRX6 H-InvDB: IRX6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRX6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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