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Aliases for IRX6 Gene

Aliases for IRX6 Gene

  • Iroquois Homeobox 6 2 3 5
  • Iroquois Homeobox Protein 6 2 3 4
  • Iroquois Homeobox Protein 7 2 3
  • Homeodomain Protein IRXB3 3 4
  • IRXB3 3 4
  • IRX7 3 4
  • Iroquois-Class Homeodomain Protein IRX-6 3
  • IRX-3 3

External Ids for IRX6 Gene

Previous HGNC Symbols for IRX6 Gene

  • IRX7

Previous GeneCards Identifiers for IRX6 Gene

  • GC16M055413
  • GC16P055096
  • GC16P055137
  • GC16P055136
  • GC16P053915
  • GC16P041244

Summaries for IRX6 Gene

GeneCards Summary for IRX6 Gene

IRX6 (Iroquois Homeobox 6) is a Protein Coding gene. Diseases associated with IRX6 include Brugada Syndrome. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX4.

Gene Wiki entry for IRX6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX6 Gene

Genomics for IRX6 Gene

Regulatory Elements for IRX6 Gene

Enhancers for IRX6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G055295 1.7 VISTA 12 -27.6 -27648 1.5 SUZ12 CBX2 EZH2 IRX6 RN7SL841P ENSG00000283423
GH16G055444 1 Ensembl ENCODE 9.8 +121.1 121141 1.4 ZMYM3 MAX ZIC2 ZNF335 GLIS2 POLR2A EED RELB IKZF2 EZH2 MMP2-AS1 MMP2 LPCAT2 IRX6 GC16P055429
GH16G055292 0.5 ENCODE 16.9 -31.1 -31117 0.2 CBX2 RBBP5 ZNF600 WT1 EZH2 IRX6 RN7SL841P ENSG00000283423
GH16G055372 0.5 ENCODE 16.5 +49.5 49494 1.4 ZSCAN21 ZMYM3 ATF2 IRX6 LOC105371279 GC16M055346
GH16G055323 1.1 Ensembl ENCODE 6.4 +0.7 688 2.2 ZSCAN4 ZNF2 RAD21 ZNF366 EGR2 SP3 ZNF398 ZNF843 ZNF341 GLIS1 IRX6 ENSG00000263207
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRX6 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRX6 Gene

Chromosome:
16
Start:
55,323,760 bp from pter
End:
55,330,760 bp from pter
Size:
7,001 bases
Orientation:
Plus strand

Genomic View for IRX6 Gene

Genes around IRX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX6 Gene

Proteins for IRX6 Gene

  • Protein details for IRX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78412-IRX6_HUMAN
    Recommended name:
    Iroquois-class homeodomain protein IRX-6
    Protein Accession:
    P78412
    Secondary Accessions:
    • B2RN06
    • Q7Z2K0

    Protein attributes for IRX6 Gene

    Size:
    446 amino acids
    Molecular mass:
    48240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX6 Gene

Post-translational modifications for IRX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX6 Gene

Domains & Families for IRX6 Gene

Gene Families for IRX6 Gene

Suggested Antigen Peptide Sequences for IRX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78412

UniProtKB/Swiss-Prot:

IRX6_HUMAN :
  • Belongs to the TALE/IRO homeobox family.
Family:
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX6: view

Function for IRX6 Gene

Gene Ontology (GO) - Molecular Function for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX6: view
genes like me logo Genes that share phenotypes with IRX6: view

Animal Models for IRX6 Gene

MGI Knock Outs for IRX6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IRX6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IRX6 Gene

Localization for IRX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRX6 gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX6: view

Pathways & Interactions for IRX6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with IRX6: view

No data available for Pathways by source and SIGNOR curated interactions for IRX6 Gene

Drugs & Compounds for IRX6 Gene

No Compound Related Data Available

Transcripts for IRX6 Gene

mRNA/cDNA for IRX6 Gene

Unigene Clusters for IRX6 Gene

Iroquois homeobox 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IRX6

Alternative Splicing Database (ASD) splice patterns (SP) for IRX6 Gene

No ASD Table

Relevant External Links for IRX6 Gene

GeneLoc Exon Structure for
IRX6
ECgene alternative splicing isoforms for
IRX6

Expression for IRX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.2), Skin - Sun Exposed (Lower leg) (x7.1), Adipose - Visceral (Omentum) (x7.1), Heart - Left Ventricle (x6.6), and Adipose - Subcutaneous (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of IRX6 Gene:

IRX6

SOURCE GeneReport for Unigene cluster for IRX6 Gene:

Hs.369907

Evidence on tissue expression from TISSUES for IRX6 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with IRX6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRX6 Gene

Orthologs for IRX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRX6 34 35
  • 98.35 (n)
cow
(Bos Taurus)
Mammalia IRX6 34 35
  • 85.33 (n)
dog
(Canis familiaris)
Mammalia IRX6 34 35
  • 84.5 (n)
mouse
(Mus musculus)
Mammalia Irx6 34 16 35
  • 79.35 (n)
rat
(Rattus norvegicus)
Mammalia Irx6 34
  • 78.86 (n)
oppossum
(Monodelphis domestica)
Mammalia IRX6 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRX6 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRX6 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irx6 34
  • 53.89 (n)
zebrafish
(Danio rerio)
Actinopterygii irx6a 34 35
  • 62.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta caup 35
  • 19 (a)
ManyToMany
ara 35
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
ManyToMany
-- 35
  • 4 (a)
ManyToMany
Species where no ortholog for IRX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX6 Gene

ENSEMBL:
Gene Tree for IRX6 (if available)
TreeFam:
Gene Tree for IRX6 (if available)

Paralogs for IRX6 Gene

Paralogs for IRX6 Gene

(3) SIMAP similar genes for IRX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX6: view

Variants for IRX6 Gene

Sequence variations from dbSNP and Humsavar for IRX6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000101716 -- 55,329,968(+) GTCCC(C/G)TGATG intron-variant
rs1000983083 -- 55,324,626(+) GGTGA(C/G)AGTGC utr-variant-5-prime
rs1001267972 -- 55,324,850(+) CTGCC(C/G)ATCCA utr-variant-5-prime
rs1001532066 -- 55,327,735(+) CAAGA(C/T)GACCC reference, missense
rs1002719303 -- 55,323,478(+) AGGTT(C/T)CATGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IRX6 Gene

Variant ID Type Subtype PubMed ID
nsv833239 CNV gain 17160897
nsv952680 CNV deletion 24416366

Variation tolerance for IRX6 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRX6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX6 Gene

Disorders for IRX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IRX6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome
  • bangungut
- elite association - COSMIC cancer census association via MalaCards
Search IRX6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRX6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRX6
genes like me logo Genes that share disorders with IRX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRX6 Gene

Publications for IRX6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Genome-wide association analyses identify variants in developmental genes associated with hypospadias. (PMID: 25108383) Geller F. … Melbye M. (Nat. Genet. 2014) 3 64
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64
  4. Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes. (PMID: 19121738) Shih B. … Bayat A. (J Hand Surg Am 2009) 22 64
  5. Exclusion of multiple candidate genes and large genomic rearrangements in SCN5A in a Dutch Brugada syndrome cohort. (PMID: 17556197) Koopmann T.T. … Bezzina C.R. (Heart Rhythm 2007) 22 64

Products for IRX6 Gene

Sources for IRX6 Gene

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