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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX6 Gene

protein-coding   GIFtS: 45
GCID: GC16P055357

Iroquois Homeobox 6

(Previous names: iroquois homeobox protein 7, iroquois homeobox protein 6)
(Previous symbol: IRX7)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Iroquois Homeobox 61 2     Homeodomain Protein IRXB32 3
IRX71 2 3 5     IRXB32 3
Iroquois Homeobox Protein 61 2 3     IRX-32
Iroquois Homeobox Protein 71 2     Iroquois-Class Homeodomain Protein IRX-62

External Ids:    HGNC: 146751   Entrez Gene: 791902   Ensembl: ENSG000001593877   OMIM: 6061965   UniProtKB: P784123   

Export aliases for IRX6 gene to outside databases

Previous GC identifers: GC16M055413 GC16P055096 GC16P055137 GC16P055136 GC16P053915 GC16P041244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IRX6 Gene: 
IRX6 (iroquois homeobox 6) is a protein-coding gene. Diseases associated with IRX6 include astigmatism, and brugada syndrome. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRX1.

Gene Wiki entry for IRX6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX6 gene promoter:
         Bach1   HFH-3   POU3F1   AP-2gamma   FOXL1   FOXI1   SRY   Nkx6-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRX6 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRX6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

IRX6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX6 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055357:  view genomic region     (about GC identifiers)

Start:
55,357,672 bp from pter      End:
55,364,672 bp from pter
Size:
7,001 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRX6_HUMAN, P78412 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-6  
Size: 446 amino acids; 48240 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RN06 Q7Z2K0

Explore the universe of human proteins at neXtProt for IRX6: NX_P78412

Explore proteomics data for IRX6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78412

  • IRX6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRX6 Protein Expression
    REFSEQ proteins: NP_077311.2  
    ENSEMBL proteins: 
     ENSP00000290552  

    Human Recombinant Protein Products for IRX6: 
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    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IRX6
    GenScript Custom Purified and Recombinant Proteins Services for IRX6
    Novus Biologicals IRX6 Proteins
    Novus Biologicals IRX6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRX6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    IRX6 for ontologies           About GeneDecksing



    IRX6 Antibody Products: 
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    Assay Products for IRX6: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for IRX6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRX6 
    Cloud-Clone Corp. CLIAs for IRX6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TALE: Homeoboxes / TALE class

    5 InterPro protein domains:
     IPR003893 Iroquois_homeo
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78412

    ProtoNet protein and cluster: P78412

    1 Blocks protein domain: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX6_HUMAN, P78412
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    IRX6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    IRX6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irx6):
     nervous system  vision/eye 

    IRX6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRX6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRX6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRX6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRX6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX6:
    hsa-miR-1197 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-520g hsa-miR-1253 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIRX6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IRX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRX6
    Sirion Biotech Customized adenovirus for overexpression of IRX6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IRX6 (see all 6)
    OriGene ORF clones in mouse, rat for IRX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRX6 (NM_024335)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX6
    Sirion Biotech Customized lentivirus for stable overexpression of IRX6 
                         Customized lentivirus expression plasmids for stable overexpression of IRX6 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IRX6
    Search LifeMap BioReagents cell lines for IRX6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX6

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----

    IRX6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX6

    Search CenterWatch for drugs/clinical trials and news about IRX6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRX6 gene: 
    NM_024335.2  

    Unigene Cluster for IRX6:

    Iroquois homeobox 6
    Hs.369907  [show with all ESTs]
    Unigene Representative Sequence: AK125053
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290552(uc002ehx.3 uc002ehy.3) ENST00000558315(uc010ccb.1)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX6
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX6:
    hsa-miR-1197 hsa-miR-520d-5p hsa-miR-524-5p hsa-miR-520g hsa-miR-1253 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidIRX6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IRX6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX6
    Clone
    Products:
         
    OriGene clones in human, mouse for IRX6 (see all 6)
    OriGene ORF clones in mouse, rat for IRX6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRX6 (NM_024335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX6
    Sirion Biotech Customized lentivirus for stable overexpression of IRX6 
                         Customized lentivirus expression plasmids for stable overexpression of IRX6 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRX6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX6

    Additional mRNA sequence: 

    AK125053.1 AK309149.1 AY335937.1 BC136573.1 BC136576.1 

    1 DOTS entry:

    DT.101980181 

    22 AceView cDNA sequences:

    BM698030 AI821795 AI792465 AK125053 AI185773 BM724662 NM_024335 BM667197 
    AI792142 AY335937 AI263887 AI820799 BM929891 BU741332 AW449920 BX114798 
    BG739786 AW149016 AI191445 AJ707304 U90305 BF204113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX6 expression in normal human tissues (normalized intensities)      IRX6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTGGAGAAA
    IRX6 Expression
    About this image


    IRX6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Type3a Off Cone Bipolar Cells Inner Nuclear Layer
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Gingival Fibroblasts (HGF)   
     
     Tendon & Ligament
             Human periodontal ligament Fibroblasts (HPLF)   
     
     Lung (Respiratory System)

    See IRX6 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.369907
        SABiosciences Custom PCR Arrays for IRX6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRX6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IRX6 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irx61 , 5 Iroquois related homeobox 6 (Drosophila)1, 5 80.18(n)1
    76.54(a)1
      8 (44.99 cM)5
    643791  NM_022428.21  NP_071873.21 
     926742895 
    chicken
    (Gallus gallus)
    Aves IRX56
    Iroquois-related homeobox transcription factor
    70(a)
    1 ↔ 1
    11(3356406-3358310)
    lizard
    (Anolis carolinensis)
    Reptilia IRX66
    Uncharacterized protein
    89(a)
    possible ortholog
    LGc(2123680-2133028)
    zebrafish
    (Danio rerio)
    Actinopterygii irx6a1 iroquois homeobox protein 6a 63.23(n)
    58.79(a)
      474317  NM_001023575.1  NP_001018869.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mirr1 mirror 49.43(n)
    41.38(a)
      39441  NM_168505.1  NP_729818.1 
    worm
    (Caenorhabditis elegans)
    Secernentea irx-16
    Putative iroquois-class homeodomain protein irx-1
    21(a)
    1 → many
    I(9536488-9540968)


    ENSEMBL Gene Tree for IRX6 (if available)
    TreeFam Gene Tree for IRX6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX6 gene
    IRX12  IRX32  IRX52  MKX2  IRX22  IRX42  
    3 SIMAP similar genes for IRX6 using alignment to 1 protein entry:     IRX6_HUMAN:
    TGIF1    IRX4    IRX1

    IRX6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/294 SNPs in IRX6 are shown (see all 294)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384560301,2
    C--55356574(+) ACTTT-/AAAAAA 1 -- us2k10--------
    rs1878204911,2
    --55356601(+) CCAAGA/CTGCAA 1 -- us2k10--------
    rs47845231,2
    C,F,A,H--55356697(+) AGGACT/CATAAT 1 -- us2k123Minor allele frequency- C:0.45NS EA NA WA CSA 2345
    rs1435405111,2
    --55356707(+) TTCTTC/TTTCTA 1 -- us2k10--------
    rs1467907151,2
    --55356809(+) GAGCTC/TGTCCT 1 -- us2k10--------
    rs1929056931,2
    --55356830(+) ATCTCC/TTAAGC 1 -- us2k10--------
    rs1852798091,2
    --55356885(+) AGAATG/TTGTTT 1 -- us2k10--------
    rs1901743561,2
    --55357026(+) GAGCCA/GTTGCT 1 -- us2k10--------
    rs310741,2
    C,F,A,H--55357170(+) TATAAA/CGCGCG 1 -- us2k1 tfbs325Minor allele frequency- C:0.36NS EA NA WA CSA 2708
    rs310751,2
    C,F,A,H--55357238(+) TGGATT/CCCTGC 1 -- us2k124Minor allele frequency- C:0.36NS EA NA WA CSA 2532

    HapMap Linkage Disequilibrium report for IRX6 (55357672 - 55364672 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IRX6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833239CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IRX6
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606196    OMIM disorders: --

    3 diseases for IRX6:    About MalaCards
    astigmatism    brugada syndrome    keratoconus

    1 disease from the University of Copenhagen DISEASES database for IRX6:
    Astigmatism

    IRX6 for disorders           About GeneDecksing


    Export disorders for IRX6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX6 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with IRX6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PubMed id 11435706)1 Ogura K.... Ogura T. (2001)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    7. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1 Lewis M.T.... Daniel C.W. (1999)
    8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
    9. Irx3 is differentially up-regulated in female gonads during sex determination. (PubMed id 15963769)9 Jorgensen J.S. and Gao L. (2005)
    10. Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes. (PubMed id 19121738)9 Shih B....Bayat A. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79190 HGNC: 14675 AceView: IRX6 Ensembl:ENSG00000159387 euGenes: HUgn79190
    ECgene: IRX6 H-InvDB: IRX6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRX6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRX6 gene:
    Search GeneIP for patents involving IRX6

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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