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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX5 Gene

protein-coding   GIFtS: 50
GCID: GC16P054964

iroquois homeobox 5
 Explore 5 diseases affiliated with
IRX5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRX5    

Aliases
for IRX5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Iroquois Homeobox 51 2     HMMS2
IRX-2a1 2     Iroquois-Class Homeodomain Protein IRX-52
Homeodomain Protein IRX-2A2 3     IRX2A3
Homeodomain Protein IRXB22 3     Iroquois Homeobox Protein 53
IRXB22 3     

External Ids:    HGNC: 143611   Entrez Gene: 102652   Ensembl: ENSG000001768427   OMIM: 6061955   UniProtKB: P784113   

Export aliases for IRX5 gene to outside databases

Previous GC identifers: GC16P045380 GC16P055020 GC16P054703 GC16P054744 GC16P054743 GC16P053522 GC16P040851


Summaries
for IRX5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRX5:
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental
processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and
that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac
repolarization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
Function: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel
gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and
control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in
the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal
development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing
CXCL12

Gene Wiki entry for IRX5


Genomic Views
for IRX5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX5 gene promoter:
         AREB6   S8   POU2F1   CP2   Sp1   POU2F1a   HTF   Lmo2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

IRX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P054964:  view genomic region     (about GC identifiers)

Start:
 54,964,774 bp from pter      End:
 54,968,397 bp from pter
Size:
 3,624 bases      Orientation:
 plus strand

Proteins
for IRX5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-5  
Size: 483 amino acids; 50361 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: P78416 Q7Z2E1

Explore the universe of human proteins at neXtProt for IRX5: NX_P78411

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78411

    • IRX5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239126.1  NP_005844.4  

    ENSEMBL proteins: 
     ENSP00000378132   ENSP00000453660   ENSP00000316250   ENSP00000453725  

    Human Recombinant Protein Products: 
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    Novus Biologicals IRX5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRX5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    IRX5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for IRX5

    Protein Domains /
    Families
    for IRX5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRX5 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003893 Iroquois_homeo
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR008422 Homeobox_KN_domain

    Graphical View of Domain Structure for InterPro Entry P78411

    ProtoNet protein and cluster: P78411

    1 Blocks protein family: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for IRX5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
    Function: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel
    gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and
    control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in
    the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal
    development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing
    CXCL12
    Induction: Down-regulated by 1,25-dihydroxyvitamin D3 in prostate cancer samples from patients assigned to receive
    weekly high-dose 1,25-dihydroxyvitamin D3 before radical prostatectomy. Also down-regulated by 1,25-dihydroxyvitamin
    D3 in the human androgen-sensitive prostate cancer cell line LNCaP and in the estrogen-sensitive breast cancer cell
    line MCF-7

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX5
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX5 (see all 17):
    hsa-miR-3934 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-221 hsa-miR-486-5p hsa-miR-374c hsa-miR-649 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: IRX5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX5 (see all 7)
    OriGene shRNA RFP: IRX5
    OriGene siRNA: IRX5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRX5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRX5 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for IRX5

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005499vitamin D binding IEA--
    GO:0043565sequence-specific DNA binding IEA--


    IRX5 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Irx5tm1Hui for IRX5
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Irx5):
     cardiovascular system  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     vision/eye 

    IRX5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRX5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IRX5 (P784113 ENSP000003781324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLFQ8IW193, ENSP000003070044I2D: score=1 STRING: ENSP00000307004
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002027regulation of heart rate IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007601visual perception IEA--
    GO:0008406gonad development IMP--
    GO:0010468regulation of gene expression ----


    IRX5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRX5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX5
    Search CenterWatch for drugs/clinical trials and news about IRX5 

    Transcripts
    for IRX5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRX5 gene (2 alternative transcripts): 
    NM_001252197.1  NM_005853.5  

    Unigene Cluster for IRX5:

    Iroquois homeobox 5
    Hs.435730  [show with all ESTs]
    Unigene Representative Sequence: NM_005853
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394636(uc002ehv.3) ENST00000560154 ENST00000320990(uc010cca.1 uc021tin.1)
    ENST00000558597(uc002ehw.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: IRX5
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX5
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX5 (see all 17):
    hsa-miR-3934 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-221 hsa-miR-486-5p hsa-miR-374c hsa-miR-649 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: IRX5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX5 (see all 7)
    OriGene shRNA RFP: IRX5
    OriGene siRNA: IRX5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX5
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IRX5 (NM_005853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX5
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRX5 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRX5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX5

    Additional cDNA sequence: 

    AY335945.1 BC074850.2 BC131510.1 U90304.1 U90309.1 

    3 DOTS entries:

    DT.307304  DT.75195253  DT.75100913 

    20 AceView cDNA sequences:

    CA421426 AI478501 AY335945 NM_005853 BU688232 BC074850 CA418934 AI499593 
    BE220331 U90304 U90309 AA972751 AA872840 BU683559 AW117436 AW016475 
    BG741901 AW302552 BF198042 AA904767 

    GeneLoc Exon Structure


    Expression
    for IRX5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCTTGGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRX5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/28 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 28) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartLeft VentricleCardiomyocytesMyocardium
    HeartOuter CurvatureCardiomyocytesMyocardium
    HeartRight VentricleCardiomyocytesMyocardium
    EyeInner Nuclear LayerCone Bipolar Precursor CellsBipolar, Retina
    EyeInner Nuclear LayerType2 Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType3a Off Cone Bipolar CellsBipolar, Retina
    EyeInner Nuclear LayerType3b Off Cone Bipolar CellsBipolar, Retina
    HeartLeft AtriumCardiomyocytesMyocardium
    HeartRight AtriumCardiomyocytesMyocardium
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See IRX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRX5

    SOURCE GeneReport for Unigene cluster: Hs.435730
        SABiosciences Custom PCR Arrays for IRX5
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    In Situ
    Assay Products:     
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    Orthologs
    for IRX5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IRX5 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NHU5_CHICK6
    IRX56
    		 Uncharacterized protein
    		 88(a)
    78(a)
    		 possible ortholog
    1 ↔ 1
    		 11(3852180-3852389)
    11(4157329-4160333)
    African clawed frog
    (Xenopus laevis)    		 Amphibia irx5-A2 iroquois-5 homeobox transcription factor 77.97(n)    AF338158.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii iro52 iroquois homeobox protein 5 78.24(n)   114431  AY017309.1 


    ENSEMBL Gene Tree for IRX5 (if available)
    TreeFam Gene Tree for IRX5 (if available) 

    Paralogs
    for IRX5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX5 gene
    IRX12  IRX32  MKX2  IRX22  IRX62  IRX42  
    4 SIMAP similar genes for IRX5 using alignment to 4 protein entries:     IRX5_HUMAN (see all proteins):
    PKNOX1    IRX2    IRX3    TGIF1

    IRX5 for paralogs           About GeneDecksing



    Genomic Variants
    for IRX5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/73 NCBI SNPs in IRX5 are shown (see all 73)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs125996231,2
    		C,H,--54963118(+) CCCCTT/CTGGCG 4 -- us2k1 tfbs39Minor allele frequency- C:0.16NA WA EA 372
    rs1471444571,2
    		--54963133(+) GACTCG/TGAGGA 4 -- us2k10--------
    rs1871603501,2
    		--54963161(+) CAGGGA/GGCGGA 4 -- us2k10--------
    rs125996351,2
    		C,F,H,--54963258(+) CTGAAG/CCGCTC 4 -- us2k112Minor allele frequency- C:0.16NA WA CSA EA 378
    rs1928802121,2
    		--54963291(+) TGGGGA/GAGGGG 4 -- us2k10--------
    rs1396093591,2
    		--54963301(+) GAGCAG/TACGGA 4 -- us2k10--------
    rs1493256031,2
    		--54963324(+) ACGCGC/TGTGCA 4 -- us2k10--------
    rs1852749901,2
    		--54963334(+) ACGAGA/CGCGCA 4 -- us2k10--------
    rs1445269161,2
    		--54963349(+) CGAGCC/GGGTGC 4 -- us2k10--------
    rs1146555481,2
    		F,--54963814(+) GGAAGG/AGGACC 4 -- us2k11Minor allele frequency- A:0.05WA 118

    HapMap Linkage Disequilibrium report for IRX5 (54964774 - 54968397 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IRX5: --
    Human Gene Mutation Database (HGMD): IRX5

    Locus Specific Mutation Databases (LSDB): IRX5

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRX5
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX5

    Disorders / Diseases
    for IRX5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRX5 for disorders           About GeneDecksing

    OMIM gene information: 606195    OMIM disorders: --

    UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
  • Defects in IRX5 are the cause of Hamamy syndrome (HMMS) [MIM:611174]. A sydrome characterized by severe
    • hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and
    osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss,
    gonadal anomalies, and borderline intelligence

    5 diseases for IRX5:    About MalaCards
    retinitis    prostate cancer    breast cancer    prostatitis
    neuronitis


    Export disorders for IRX5 gene to outside databases

    Publications
    for IRX5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX5 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with IRX5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells. (PubMed id 18519790)1, 2, 9 Myrthue A....Beer T.M. (2008)
    2. Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1. (PubMed id 22581230)1, 2 Bonnard C....Reversade B. (2012)
    3. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1, 2 Lewis M.T.... Daniel C.W. (1999)
    4. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1 Murea M....Freedman B.I. (2011)
    5. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. (PubMed id 17396150)1 Kanno S....Yasui A. (2007)
    6. [Irx5: a transcription factor that regulates the cardiac repolarization gradient] (PubMed id 16527195)1 Bruneau B.G. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PubMed id 11435706)1 Ogura K.... Ogura T. (2001)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    10. Developmental expression of the Xenopus Iroquois-family homeobox genes, Irx4 and Irx5. (PubMed id 11455441)9 Garriock R.J....Krieg P.A. (2001)

    External Searches for IRX5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IRX5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10265 HGNC: 14361 AceView: IRX5 Ensembl:ENSG00000176842 euGenes: HUgn10265
    ECgene: IRX5 H-InvDB: IRX5

    Other Databases showing IRX5 gene

    (According to HUGE)
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    Specialized Databases showing IRX5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRX5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IRX5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for IRX5 gene:
    Search GeneIP for patents involving IRX5

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