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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX5 Gene

protein-coding   GIFtS: 53
GCID: GC16P054964

Iroquois Homeobox 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Iroquois Homeobox 51 2     IRX-2a2
Homeodomain Protein IRX-2A2 3     Iroquois-Class Homeodomain Protein IRX-52
Homeodomain Protein IRXB22 3     IRX2A3
IRXB22 3     Iroquois Homeobox Protein 53
HMMS2     

External Ids:    HGNC: 143611   Entrez Gene: 102652   Ensembl: ENSG000001768427   OMIM: 6061955   UniProtKB: P784113   

Export aliases for IRX5 gene to outside databases

Previous GC identifers: GC16P045380 GC16P055020 GC16P054703 GC16P054744 GC16P054743 GC16P053522 GC16P040851


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRX5 Gene:
This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic
developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell
differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure
coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for IRX5 Gene: 
IRX5 (iroquois homeobox 5) is a protein-coding gene. Diseases associated with IRX5 include hamamy syndrome, and sensorineural hearing loss. GO annotations related to this gene include vitamin D binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRX1.

UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
Function: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel
gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and
control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be
involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in
craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches
and gonads by repressing CXCL12

Gene Wiki entry for IRX5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX5 gene promoter:
         AREB6   S8   POU2F1   CP2   Sp1   POU2F1a   HTF   Lmo2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRX5 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRX5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

IRX5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P054964:  view genomic region     (about GC identifiers)

Start:
54,964,774 bp from pter      End:
54,968,397 bp from pter
Size:
3,624 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-5  
Size: 483 amino acids; 50361 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: H0YMS7 P78416 Q7Z2E1
Alternative splicing: 3 isoforms:  P78411-1   P78411-2   P78411-3   

Explore the universe of human proteins at neXtProt for IRX5: NX_P78411

Explore proteomics data for IRX5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78411

  • IRX5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRX5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001239126.1  NP_005844.4  

    ENSEMBL proteins: 
     ENSP00000378132   ENSP00000453660   ENSP00000316250   ENSP00000453725  

    Human Recombinant Protein Products for IRX5: 
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    Novus Biologicals IRX5 Protein
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    Cloud-Clone Corp. Proteins for IRX5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    IRX5 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for IRX5 
    Cloud-Clone Corp. CLIAs for IRX5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TALE: Homeoboxes / TALE class

    5 InterPro protein domains:
     IPR003893 Iroquois_homeo
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78411

    ProtoNet protein and cluster: P78411

    1 Blocks protein domain: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    IRX5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRX5_HUMAN, P78411
    Function: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel
    gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and
    control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be
    involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in
    craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches
    and gonads by repressing CXCL12
    Induction: Down-regulated by 1,25-dihydroxyvitamin D3 in prostate cancer samples from patients assigned to receive
    weekly high-dose 1,25-dihydroxyvitamin D3 before radical prostatectomy. Also down-regulated by
    1,25-dihydroxyvitamin D3 in the human androgen-sensitive prostate cancer cell line LNCaP and in the
    estrogen-sensitive breast cancer cell line MCF-7

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005499vitamin D binding IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    IRX5 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Irx5):
     cardiovascular system  growth/size  mortality/aging  nervous system  no phenotypic analysis 
     vision/eye 

    IRX5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irx5tm1Hui for IRX5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRX5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRX5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRX5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRX5 

    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX5 (see all 17):
    hsa-miR-3934 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-221 hsa-miR-486-5p hsa-miR-374c hsa-miR-649 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidIRX5 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for IRX5 (P784113 ENSP000003781324) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLFQ8IW193, ENSP000003070044I2D: score=1 STRING: ENSP00000307004
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002027regulation of heart rate IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007601visual perception IEA--
    GO:0008406gonad development IMP--

    IRX5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX5

    Search CenterWatch for drugs/clinical trials and news about IRX5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRX5 gene (2 alternative transcripts): 
    NM_001252197.1  NM_005853.5  

    Unigene Cluster for IRX5:

    Iroquois homeobox 5
    Hs.435730  [show with all ESTs]
    Unigene Representative Sequence: NM_005853
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394636(uc002ehv.3) ENST00000560154 ENST00000320990(uc010cca.1 uc021tin.1)
    ENST00000558597(uc002ehw.3)
    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX5 (see all 17):
    hsa-miR-3934 hsa-miR-520d-5p hsa-let-7a-2* hsa-miR-221 hsa-miR-486-5p hsa-miR-374c hsa-miR-649 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidIRX5 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: IRX5 (NM_005853)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX5
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRX5
    Sirion Biotech Customized lentivirus for stable overexpression of IRX5 
                         Customized lentivirus expression plasmids for stable overexpression of IRX5 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX5

    Additional mRNA sequence: 

    AY335945.1 BC074850.2 BC131510.1 U90304.1 U90309.1 

    3 DOTS entries:

    DT.307304  DT.75195253  DT.75100913 

    20 AceView cDNA sequences:

    AY335945 CA421426 AI478501 NM_005853 U90309 CA418934 U90304 AI499593 
    BU688232 BE220331 AA972751 BC074850 BG741901 AW117436 BU683559 AW016475 
    AA872840 AW302552 AA904767 BF198042 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX5 expression in normal human tissues (normalized intensities)      IRX5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTTGGCAG
    IRX5 Expression
    About this image


    IRX5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Zeugopod Long Bone
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
             skeleton/pectoral girdle and thoracic body wall/scapula   
     
     Heart (Cardiovascular System)    fully expand to see all 7 entries
             Cardiomyocytes Left Ventricle
             left ventricular apex samples   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Type3a Off Cone Bipolar Cells Inner Nuclear Layer
             Human Keratocyte (HK)   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Bud Mesenchyme Cells Limb Bud
             Pelvic Girdle
             limb/hindlimb/hind-paw   
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             skeleton/axial skeleton   

    See IRX5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRX5

    SOURCE GeneReport for Unigene cluster: Hs.435730
        SABiosciences Custom PCR Arrays for IRX5
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IRX5 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irx51 , 5 Iroquois related homeobox 5 (Drosophila)1, 5 89.56(n)1
    93.36(a)1
      8 (44.93 cM)5
    543521  NM_018826.21  NP_061296.11 
     923577965 
    African clawed frog
    (Xenopus laevis)
    Amphibia irx5-A2 iroquois-5 homeobox transcription factor 77.97(n)    AF338158.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iro52 iroquois homeobox protein 5 78.24(n)   114431  AY017309.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mirr3 positive regulation of transcription
    transcription more
    77(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea irx-16
    Putative iroquois-class homeodomain protein irx-1
    23(a)
    1 → many
    I(9536488-9540968)


    ENSEMBL Gene Tree for IRX5 (if available)
    TreeFam Gene Tree for IRX5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX5 gene
    IRX12  IRX32  MKX2  IRX22  IRX62  IRX42  
    2 SIMAP similar genes for IRX5 using alignment to 3 protein entries:     IRX5_HUMAN (see all proteins):
    IRX2    TGIF1

    IRX5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in IRX5 are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0684834
    Hamamy syndrome (HMMS)4--see VAR_0684832 A P mis40--------
    VAR_0684844
    Hamamy syndrome (HMMS)4--see VAR_0684842 N K mis40--------
    rs347062341,2
    C--54965437(+) CGGGCC/TTAGGC 2 -- int11Minor allele frequency- T:0.00NA 2
    rs11364121,2
    C,H--54965541(-) CTTTTC/GCGAGC 2 -- int115Minor allele frequency- G:0.03MN NA WA CSA EA 563
    rs1396311441,2
    --54965542(+) CTCGCA/GAAAGA 2 -- int10--------
    rs778420371,2
    C,F--54965697(+) AAGTAG/ATTCAA 2 -- int11Minor allele frequency- A:0.06NA 120
    rs736286511,2
    C,F--54965701(+) AGTTCG/AAAAGA 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1847352031,2
    --54965758(+) TGTTTA/GGCCTA 2 -- int10--------
    rs1998255481,2
    --54966360(+) TCCGAC/TGGCAG 2 -- int10--------
    rs2016842911,2
    C--54966376(+) ACCACG/TGTCCA 2 -- int11Minor allele frequency- T:0.00EU 1297

    HapMap Linkage Disequilibrium report for IRX5 (54964774 - 54968397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IRX5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv827657CNV Gain20364138
    dgv476n67CNV Gain20364138


    Human Gene Mutation Database (HGMD): IRX5

    Locus Specific Mutation Databases (LSDB): IRX5
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing IRX5
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606195    OMIM disorders: --

    UniProtKB/Swiss-Prot: IRX5_HUMAN, P78411
  • Hamamy syndrome (HMMS) [MIM:611174]: A syndrome characterized by severe hypertelorism, upslanting
    palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with
    repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal
    anomalies and borderline intelligence. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 8 diseases for IRX5:    About MalaCards
    hamamy syndrome    sensorineural hearing loss    retinitis    myopia
    prostate cancer    prostatitis    breast cancer    neuronitis


    IRX5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IRX5

    Export disorders for IRX5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with IRX5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells. (PubMed id 18519790)1, 2, 9 Myrthue A....Beer T.M. (2008)
    2. Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1. (PubMed id 22581230)1, 2 Bonnard C....Reversade B. (2012)
    3. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1, 2 Lewis M.T.... Daniel C.W. (1999)
    4. Whole genome association scan for genetic polymorphis ms influencing information processing speed. (PubMed id 21130836)4 Luciano M....Deary I.J. (2011)
    5. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1 Murea M....Freedman B.I. (2011)
    6. A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses. (PubMed id 17396150)1 Kanno S....Yasui A. (2007)
    7. [Irx5: a transcription factor that regulates the cardiac repolarization gradient] (PubMed id 16527195)1 Bruneau B.G. (2006)
    8. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PubMed id 11435706)1 Ogura K.... Ogura T. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10265 HGNC: 14361 AceView: IRX5 Ensembl:ENSG00000176842 euGenes: HUgn10265
    ECgene: IRX5 H-InvDB: IRX5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRX5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRX5 gene:
    Search GeneIP for patents involving IRX5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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