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IRX4 Gene

protein-coding   GIFtS: 55
GCID: GC05M001930

Iroquois Homeobox 4

(Previous name: iroquois homeobox protein 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Iroquois Homeobox 41 2
Iroquois Homeobox Protein 41 2 3
Homeodomain Protein IRXA32 3
IRXA32 3
Iroquois-Class Homeodomain Protein IRX-42

External Ids:    HGNC: 61291   Entrez Gene: 508052   Ensembl: ENSG000001134307   OMIM: 6061995   UniProtKB: P784133   

Export aliases for IRX4 gene to outside databases

Previous GC identifers: GC05M002018 GC05M001910


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IRX4 Gene:
IRX4 (iroquois homeobox 4) is a protein-coding gene. Diseases associated with IRX4 include hypertrophic cardiomyopathy, and migraine. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRX1.

UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
Function: Likely to be an important mediator of ventricular differentiation during cardiac development

Gene Wiki entry for IRX4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRX4 gene promoter:
         p53   ATF-2   CUTL1   LCR-F1   HEN1   S8   c-Jun   Pax-4a   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRX4 promoter sequence
   Search Chromatin IP Primers for IRX4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

IRX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001930:  view genomic region     (about GC identifiers)

Start:
1,877,541 bp from pter      End:
1,887,350 bp from pter
Size:
9,810 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-4  
Size: 519 amino acids; 54445 Da
Secondary accessions: B2RMW5 D3DTC5 Q2NL64 Q9UHR2

Explore the universe of human proteins at neXtProt for IRX4: NX_P78413

Explore proteomics data for IRX4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRX4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265561.1  NP_001265562.1  NP_001265563.1  NP_001265564.1  NP_057442.1  

    ENSEMBL proteins: 
     ENSP00000231357   ENSP00000423161   ENSP00000422462   ENSP00000424235   ENSP00000421772  

    IRX4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for IRX4
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    Novus Biologicals IRX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRX4

    IRX4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
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    Abcam antibodies for IRX4 (Q2NL64, P78413)
    Cloud-Clone Corp. Antibodies for IRX4
    Search ThermoFisher Antibodies for IRX4
    LSBio Antibodies in human, mouse, rat for IRX4

    IRX4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRX4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRX4
    Cloud-Clone Corp. CLIAs for IRX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    5 InterPro protein domains:
     IPR003893 Iroquois_homeo
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78413

    ProtoNet protein and cluster: P78413

    1 Blocks protein domain: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    IRX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRX4_HUMAN, P78413
    Function: Likely to be an important mediator of ventricular differentiation during cardiac development

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    IRX4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IRX4:
     Increased HPV18 LCR reporter a 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irx4):
     cardiovascular system  muscle 

    IRX4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irx4tm1Jse for IRX4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRX4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRX4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRX4

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRX4:
    hsa-mir-192-5p (MIRT026778), hsa-mir-215-5p (MIRT024687)

    Block miRNA regulation of human, mouse, rat IRX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRX4 (see all 23):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-30d hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidIRX4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRX4
    Predesigned siRNA for gene silencing in human, mouse, rat IRX4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRX4

    Clone
    Products:
         
    OriGene clones in human, mouse for IRX4 (see all 6)
    OriGene ORF clones in mouse, rat for IRX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRX4 (NM_016358)
    Sino Biological Human cDNA Clone for IRX4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IRX4
    Browse ESI BIO Cell Lines and PureStem Progenitors for IRX4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRX4_HUMAN, P78413: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    IRX4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRX4 About    
    See pathways by source

    SuperPathContained pathways About
    1Heart Development
    Heart Development
    2Cardiac Progenitor Differentiation
    Cardiac Progenitor Differentiation


    2 BioSystems Pathways for IRX4
        Heart Development
    Cardiac Progenitor Differentiation



        Pathway & Disease-focused RT2 Profiler PCR Array including IRX4: 
              Stem Cell Transcription Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IRX4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for IRX4 (P784133 ENSP000002313574) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102763, ENSP000002540664I2D: score=2 STRING: ENSP00000254066
    MTX2ENSP000002494424STRING: ENSP00000249442
    LFNGENSP000002227254STRING: ENSP00000222725
    MFNGENSP000003494904STRING: ENSP00000349490
    RFNGENSP000003079714STRING: ENSP00000307971
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007507heart development IEA--
    GO:0048561establishment of organ orientation IEA--

    IRX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRX4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IRX4 gene (5 alternative transcripts): 
    NM_001278632.1  NM_001278633.1  NM_001278634.1  NM_001278635.1  NM_016358.2  

    Unigene Cluster for IRX4:

    Iroquois homeobox 4
    Hs.196927  [show with all ESTs]
    Unigene Representative Sequence: AB690781
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231357(uc003jcz.2 uc011cmf.1) ENST00000505790 ENST00000508261
    ENST00000513692 ENST00000505938 ENST00000511126
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRX4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRX4 (see all 23):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-30d hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidIRX4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IRX4
    Predesigned siRNA for gene silencing in human, mouse, rat IRX4
    Clone
    Products:
         
    OriGene clones in human, mouse for IRX4 (see all 6)
    OriGene ORF clones in mouse, rat for IRX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRX4 (NM_016358)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IRX4
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRX4
      QuantiTect SYBR Green Assays in human, mouse, rat IRX4
      QuantiFast Probe-based Assays in human, mouse, rat IRX4

    Additional mRNA sequence: 

    AB690778.1 AB690779.1 AB690780.1 AB690781.1 AF124733.1 BC110912.1 BC136505.1 BC136506.1 
    BC144204.1 U90306.1 

    2 DOTS entries:

    DT.70102786  DT.91815811 

    17 AceView cDNA sequences:

    AI671516 AI652266 AI950190 BE734058 NM_016358 BV191723 AF124733 BG335143 
    U90306 BE732926 BE407995 BF831125 AI246240 BE281254 BM563164 AI566193 
    BE542576 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAAGGCGG
    IRX4 Expression
    About this image


    IRX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Globus Pallidus
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    IRX4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRX4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.196927

    UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
    Tissue specificity: Predominantly expressed in cardiac ventricles

        Pathway & Disease-focused RT2 Profiler PCR Array including IRX4: 
              Stem Cell Transcription Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IRX4
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX4
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    QuantiTect SYBR Green Assays in human, mouse, rat IRX4
    QuantiFast Probe-based Assays in human, mouse, rat IRX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IRX4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irx41 , 5 Iroquois related homeobox 4 (Drosophila)1, 5 80.56(n)1
    82.19(a)1
      13 (39.64 cM)5
    509161  NM_018885.21  NP_061373.11 
     732604975 
    chicken
    (Gallus gallus)
    Aves IRX41 iroquois homeobox 4 75.78(n)
    73.31(a)
      373974  NM_001001744.1  NP_001001744.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRX46
    iroquois homeobox 4
    69(a)
    1 ↔ 1
    4(68576835-68605372)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120862 Xenopus laevis iroquois-4 homeobox transcription factor more 75.77(n)    AF338157.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257752 Danio rerio cDNA clone IMAGE6799862, containing frame-shift more 77.98(n)    BC053310.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta caup3 regulation of transcription from Pol II
    promoter more
    49(a)
    (best of 3)
      3 69D1   --


    ENSEMBL Gene Tree for IRX4 (if available)
    TreeFam Gene Tree for IRX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRX4 gene
    IRX12  IRX32  IRX52  MKX2  IRX22  IRX62  
    3 SIMAP similar genes for IRX4 using alignment to 5 protein entries:     IRX4_HUMAN (see all proteins):
    TGIF2    TGIF1    IRX6

    IRX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRX4 (see all 210)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1867027701,2
    --1877098(+) AATAGA/GAGAGC 1 -- int10--------
    rs1144141721,2
    F--1877157(+) CTCCTG/ACCTAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1487957301,2
    --1877177(+) AGGCCA/GCTAAC 1 -- int10--------
    rs113228511,2
    C--1877210(+) CCACG-/C/GCCCCC 1 -- int10--------
    rs1117554131,2
    C--1877214(+) GCCCCA/C/TCCCCG 1 -- int10--------
    rs16849711,2
    C--1877218(+) CCCCCC/GGGGAC 1 -- int17Minor allele frequency- G:0.15NA CSA WA 246
    rs1823690831,2
    --1877254(+) AAAATA/CTAATC 1 -- int10--------
    rs1449683821,2
    C--1877257(+) ATCTAA/GTCAAA 1 -- int10--------
    rs49757091,2
    C,F,A,H--1877280(+) TTTTCA/CAACTT 1 -- int116Minor allele frequency- C:0.30NS EA CSA WA NA 2336
    rs1866356171,2
    --1877328(+) CACACC/TCACTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for IRX4 (1877541 - 1887350 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for IRX4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv881557CNV Loss21882294
    dgv5924n71CNV Loss21882294
    nsv822961CNV Loss20364138
    esv25789CNV Loss19812545
    dgv5925n71CNV Loss21882294
    dgv5926n71CNV Loss21882294
    nsv822962CNV Gain20364138

    Human Gene Mutation Database (HGMD): IRX4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRX4
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606199    OMIM disorders: --

    8 diseases for IRX4:    
    About MalaCards
    hypertrophic cardiomyopathy    migraine    gingivitis    prostate cancer
    prostatitis    pancreatic cancer    cerebritis    pancreatitis


    IRX4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IRX4
    Human Genome Epidemiology (HuGE) Navigator: IRX4 (5 documents)

    Export disorders for IRX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRX4 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with IRX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. (PubMed id 10625552)1, 2, 3, 9 Bruneau B.G.... Seidman C.E. (Dev. Biol. 2000)
    2. Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study. (PubMed id 21779381)1, 4 SchA1rks M....Kurth T. (PLoS ONE 2011)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. (PubMed id 18497553)1, 4 Bayrak F....Erginel-Unaltuna N. (Turk Kardiyol Dern Ars 2008)
    5. Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression. (PubMed id 11382777)1, 9 Wang G.F....Stockdale F.E. (J. Biol. Chem. 2001)
    6. IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. (PubMed id 22323358)1 Nguyen H.H....Nakagawa H. (Hum. Mol. Genet. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Two novel mutations of the IRX4 gene in patients with congenital heart disease. (PubMed id 21544582)1 Cheng Z....Ma X. (Hum. Genet. 2011)
    9. Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population. (PubMed id 20676098)4 Takata R....Nakagawa H. (Nat. Genet. 2010)
    10. Genome-wide association study of pancreatic cancer in Japanese population. (PubMed id 20686608)4 Low S.K....Sakamoto H. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50805 HGNC: 6129 AceView: IRX4 Ensembl:ENSG00000113430 euGenes: HUgn50805
    ECgene: IRX4 H-InvDB: IRX4

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IRX4 gene:
    Search GeneIP for patents involving IRX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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