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Aliases for IRX4 Gene

Aliases for IRX4 Gene

  • Iroquois Homeobox 4 2 3 5
  • Iroquois Homeobox Protein 4 2 3 4
  • Homeodomain Protein IRXA3 3 4
  • IRXA3 3 4
  • Iroquois-Class Homeodomain Protein IRX-4 3

External Ids for IRX4 Gene

Previous GeneCards Identifiers for IRX4 Gene

  • GC05M002018
  • GC05M001910

Summaries for IRX4 Gene

GeneCards Summary for IRX4 Gene

IRX4 (Iroquois Homeobox 4) is a Protein Coding gene. Diseases associated with IRX4 include Familial Atrial Fibrillation. Among its related pathways are Heart Development and Cardiac Progenitor Differentiation. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX6.

UniProtKB/Swiss-Prot for IRX4 Gene

  • Likely to be an important mediator of ventricular differentiation during cardiac development.

Gene Wiki entry for IRX4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX4 Gene

Genomics for IRX4 Gene

Regulatory Elements for IRX4 Gene

Enhancers for IRX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F002093 0.6 ENCODE 6.3 -207.0 -206951 2.1 IRF2 L3MBTL2 CREB3L1 NRF1 MAFG USF2 NR3C1 RAD51 NFE2 IRF1 IRX4 IRX2 LOC105374618 GC05M002149
GH05F001948 1 Ensembl ENCODE 5.3 -62.2 -62237 2.7 ZNF493 ZNF133 GLI4 ZNF2 GLIS2 ZNF416 ZNF548 FOS SP3 YY2 LOC100132773 CTD-2194D22.4 LINC02116 MTCO2P32 LOC105374620 LOC728613 MRPL36 NDUFS6 ENSG00000249731 ENSG00000248994
GH05F001882 0.6 ENCODE 0.8 +1.8 1781 7.9 PKNOX1 KLF17 ZNF335 GLIS2 SCRT2 CREM EGR2 SP3 ZEB2 ZNF645 CTD-2194D22.4 LINC02116 MTCO2P32 LOC100132773 LOC728613 ENSG00000271119 MRPL36 ENSG00000248597 SLC6A3 LOC101929056
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around IRX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRX4 Gene

Chromosome:
5
Start:
1,877,413 bp from pter
End:
1,887,236 bp from pter
Size:
9,824 bases
Orientation:
Minus strand

Genomic View for IRX4 Gene

Genes around IRX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX4 Gene

Proteins for IRX4 Gene

  • Protein details for IRX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78413-IRX4_HUMAN
    Recommended name:
    Iroquois-class homeodomain protein IRX-4
    Protein Accession:
    P78413
    Secondary Accessions:
    • B2RMW5
    • D3DTC5
    • H1AFL0
    • H1AFL1
    • Q2NL64
    • Q9UHR2

    Protein attributes for IRX4 Gene

    Size:
    519 amino acids
    Molecular mass:
    54445 Da
    Quaternary structure:
    • Interacts with the vitamin D receptor VDR but doesnt affect its transactivation activity.

    Alternative splice isoforms for IRX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IRX4 Gene

Post-translational modifications for IRX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IRX4 Gene

Domains & Families for IRX4 Gene

Gene Families for IRX4 Gene

Suggested Antigen Peptide Sequences for IRX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78413

UniProtKB/Swiss-Prot:

IRX4_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX4: view

Function for IRX4 Gene

Molecular function for IRX4 Gene

UniProtKB/Swiss-Prot Function:
Likely to be an important mediator of ventricular differentiation during cardiac development.

Gene Ontology (GO) - Molecular Function for IRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX4: view
genes like me logo Genes that share phenotypes with IRX4: view

Animal Models for IRX4 Gene

MGI Knock Outs for IRX4:

Animal Model Products

miRNA for IRX4 Gene

miRTarBase miRNAs that target IRX4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRX4 Gene

Localization for IRX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRX4 Gene COMPARTMENTS Subcellular localization image for IRX4 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for IRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX4: view

Pathways & Interactions for IRX4 Gene

genes like me logo Genes that share pathways with IRX4: view

Pathways by source for IRX4 Gene

2 BioSystems pathways for IRX4 Gene

Gene Ontology (GO) - Biological Process for IRX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007507 heart development IEA,TAS --
GO:0048561 establishment of animal organ orientation IEA --
genes like me logo Genes that share ontologies with IRX4: view

No data available for SIGNOR curated interactions for IRX4 Gene

Transcripts for IRX4 Gene

Unigene Clusters for IRX4 Gene

Iroquois homeobox 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRX4 Gene

No ASD Table

Relevant External Links for IRX4 Gene

GeneLoc Exon Structure for
IRX4
ECgene alternative splicing isoforms for
IRX4

Expression for IRX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRX4 Gene

mRNA differential expression in normal tissues according to GTEx for IRX4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x10.5), Esophagus - Mucosa (x8.3), Skin - Sun Exposed (Lower leg) (x8.0), Heart - Left Ventricle (x6.3), Vagina (x5.1), Minor Salivary Gland (x4.9), and Prostate (x4.6).

Protein differential expression in normal tissues from HIPED for IRX4 Gene

This gene is overexpressed in Heart (45.5) and Peripheral blood mononuclear cells (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRX4 Gene



Protein tissue co-expression partners for IRX4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRX4 Gene:

IRX4

SOURCE GeneReport for Unigene cluster for IRX4 Gene:

Hs.196927

mRNA Expression by UniProt/SwissProt for IRX4 Gene:

P78413-IRX4_HUMAN
Tissue specificity: Predominantly expressed in cardiac ventricles.
genes like me logo Genes that share expression patterns with IRX4: view

Primer Products

Orthologs for IRX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IRX4 34 35
  • 87.66 (n)
dog
(Canis familiaris)
Mammalia IRX4 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irx4 34 16 35
  • 80.56 (n)
rat
(Rattus norvegicus)
Mammalia Irx4 34
  • 79.71 (n)
chimpanzee
(Pan troglodytes)
Mammalia IRX4 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRX4 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRX4 34 35
  • 75.78 (n)
lizard
(Anolis carolinensis)
Reptilia IRX4 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irx4 34
  • 64.8 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12086 34
zebrafish
(Danio rerio)
Actinopterygii irx4a 34 35
  • 70.1 (n)
irx4b 35
  • 46 (a)
OneToMany
Dr.25775 34
fruit fly
(Drosophila melanogaster)
Insecta caup 36 35
  • 49 (a)
mirr 36
  • 48 (a)
ara 36 35
  • 47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 21 (a)
ManyToMany
-- 35
  • 10 (a)
ManyToMany
Species where no ortholog for IRX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX4 Gene

ENSEMBL:
Gene Tree for IRX4 (if available)
TreeFam:
Gene Tree for IRX4 (if available)

Paralogs for IRX4 Gene

Paralogs for IRX4 Gene

(3) SIMAP similar genes for IRX4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with IRX4: view

Variants for IRX4 Gene

Sequence variations from dbSNP and Humsavar for IRX4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10055816 -- 1,887,819(+) CCCTA(C/G)CCGGC intron-variant, upstream-variant-2KB
rs10055957 -- 1,888,036(+) GCCTG(A/G)GGTCA intron-variant, upstream-variant-2KB
rs10062647 -- 1,885,440(+) TCTCC(C/G)TGACC intron-variant, upstream-variant-2KB
rs10071235 -- 1,887,568(+) GGACG(C/G)TTGGG intron-variant, upstream-variant-2KB
rs10073159 -- 1,888,318(+) CAGCC(C/T)CAGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IRX4 Gene

Variant ID Type Subtype PubMed ID
dgv9542n54 CNV loss 21841781
esv25789 CNV loss 19812545
nsv1073845 CNV deletion 25765185
nsv1074801 CNV deletion 25765185
nsv822961 CNV loss 20364138
nsv822962 CNV gain 20364138
nsv822963 CNV gain 20364138
nsv950633 CNV deletion 24416366

Variation tolerance for IRX4 Gene

Gene Damage Index Score: 5.59; 72.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRX4 Gene

Human Gene Mutation Database (HGMD)
IRX4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX4 Gene

Disorders for IRX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IRX4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
familial atrial fibrillation
  • atrial fibrillation, familial, 1
- elite association - COSMIC cancer census association via MalaCards
Search IRX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRX4

Genetic Association Database (GAD)
IRX4
Human Genome Epidemiology (HuGE) Navigator
IRX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRX4
genes like me logo Genes that share disorders with IRX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRX4 Gene

Publications for IRX4 Gene

  1. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. (PMID: 10625552) Bruneau B.G. … Seidman C.E. (Dev. Biol. 2000) 2 3 4 22 64
  2. IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibility. (PMID: 22323358) Nguyen H.H. … Nakagawa H. (Hum. Mol. Genet. 2012) 3 4 64
  3. Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study. (PMID: 21779381) SchA1rks M. … Kurth T. (PLoS ONE 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. (PMID: 18497553) Bayrak F. … Erginel-Unaltuna N. (Turk Kardiyol Dern Ars 2008) 3 46 64

Products for IRX4 Gene

Sources for IRX4 Gene

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