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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX4 Gene

protein-coding   GIFtS: 54
GCID: GC05M001930

iroquois homeobox 4

(Previous name: iroquois homeobox protein 4 )
 Explore 3 diseases affiliated with
IRX4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRX4    

Aliases
for IRX4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Iroquois Homeobox 41 2     Iroquois-Class Homeodomain Protein IRX-4 Variant 12
Iroquois Homeobox Protein 41 2 3     Iroquois-Class Homeodomain Protein IRX-4 Variant 22
Homeodomain Protein IRXA32 3     Iroquois-Class Homeodomain Protein IRX-4 Variant 32
IRXA32 3     Iroquois-Class Homeodomain Protein IRX-4 Variant 42
Iroquois-Class Homeodomain Protein IRX-42     

External Ids:    HGNC: 61291   Entrez Gene: 508052   Ensembl: ENSG000001134307   OMIM: 6061995   UniProtKB: P784133   

Export aliases for IRX4 gene to outside databases

Previous GC identifers: GC05M002018 GC05M001910


Summaries
for IRX4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
Function: Likely to be an important mediator of ventricular differentiation during cardiac development

Gene Wiki entry for IRX4


Genomic Views
for IRX4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX4 gene promoter:
         p53   ATF-2   CUTL1   LCR-F1   HEN1   S8   c-Jun   Pax-4a   AP-2alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRX4 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

IRX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M001930:  view genomic region     (about GC identifiers)

Start:
 1,877,541 bp from pter      End:
 1,887,350 bp from pter
Size:
 9,810 bases      Orientation:
 minus strand

Proteins
for IRX4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-4  
Size: 519 amino acids; 54445 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: B2RMW5 D3DTC5 Q2NL64 Q9UHR2

Explore the universe of human proteins at neXtProt for IRX4: NX_P78413

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78413

    • IRX4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057442.1  
    ENSEMBL proteins: 
     ENSP00000231357   ENSP00000423161   ENSP00000422462   ENSP00000424235   ENSP00000421772  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: IRX4
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    Novus Biologicals IRX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRX4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    IRX4 for ontologies           About GeneDecksing



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    Uscn Antibodies for IRX4
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    Uscn ELISAs and CLIAs for IRX4

    Protein Domains /
    Families
    for IRX4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRX4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003893 Iroquois_homeo
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR008422 Homeobox_KN_domain

    Graphical View of Domain Structure for InterPro Entry P78413

    ProtoNet protein and cluster: P78413

    1 Blocks protein family: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for IRX4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
    Function: Likely to be an important mediator of ventricular differentiation during cardiac development

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX4
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX4 (see all 23):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-30d hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: IRX4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX4 (see all 7)
    OriGene shRNA RFP: IRX4
    OriGene siRNA: IRX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRX4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRX4 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IRX4
    Search LifeMap BioReagents cell lines for IRX4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX4

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    IRX4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IRX4:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-out Irx4tm1Jse for IRX4
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Irx4):
     cardiovascular system  muscle 

    IRX4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRX4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Heart Development
    		Heart Development1.00


    1 BioSystems Pathway for IRX4 
        Heart Development


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX4

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for IRX4 (P784133 ENSP000002313574) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102763, ENSP000002540664I2D: score=2 STRING: ENSP00000254066
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007507heart development IEA--
    GO:0048561establishment of organ orientation IEA--


    IRX4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRX4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX4
    Search CenterWatch for drugs/clinical trials and news about IRX4 

    Transcripts
    for IRX4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRX4 gene: 
    NM_016358.2  

    Unigene Cluster for IRX4:

    Iroquois homeobox 4
    Hs.196927  [show with all ESTs]
    Unigene Representative Sequence: AB690781
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000231357(uc003jcz.2 uc011cmf.1) ENST00000505790 ENST00000508261
    ENST00000513692 ENST00000505938 ENST00000511126

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX4
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX4 (see all 23):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-302e hsa-miR-30d hsa-miR-512-3p hsa-miR-520a-3p hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmid: IRX4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX4 (see all 7)
    OriGene shRNA RFP: IRX4
    OriGene siRNA: IRX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX4
    Clone
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    GenScript: all cDNA clones in your preferred vector: IRX4 (NM_016358)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX4

    Additional cDNA sequence: 

    AB690778.1 AB690779.1 AB690780.1 AB690781.1 AF124733.1 BC110912.1 BC136505.1 BC136506.1 
    BC144204.1 U90306.1 

    2 DOTS entries:

    DT.70102786  DT.91815811 

    17 AceView cDNA sequences:

    AI671516 AI652266 BE734058 AI950190 NM_016358 AF124733 U90306 BE407995 
    BV191723 BG335143 BE732926 BF831125 AI246240 BM563164 AI566193 BE281254 
    BE542576 

    GeneLoc Exon Structure


    Expression
    for IRX4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGAAGGCGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRX4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMandibular ProcessBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IRX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRX4

    SOURCE GeneReport for Unigene cluster: Hs.196927

    UniProtKB/Swiss-Prot: IRX4_HUMAN, P78413
    Tissue specificity: Predominantly expressed in cardiac ventricles

        SABiosciences Expression via Pathway-Focused PCR Array including IRX4: 
              Stem Cell Transcription Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX4

    Orthologs
    for IRX4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for IRX4 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IRX41 iroquois homeobox 4 77.19(n)
    75(a)    		   373974  NM_001001744.1  NP_001001744.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IRX46
    		 --
    		 63(a)
    		 1 ↔ 1
    		 4(68577654-68592179)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.120862 Xenopus laevis iroquois-4 homeobox transcription factor more 75.77(n)    AF338157.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.257752 Danio rerio cDNA clone IMAGE6799862, containing frame-shift more 77.98(n)    BC053310.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta caup3 regulation of transcription from Pol II
    promoter more    		 49(a)
    (best of 3)    		   3 69D1   --


    ENSEMBL Gene Tree for IRX4 (if available)
    TreeFam Gene Tree for IRX4 (if available) 

    Paralogs
    for IRX4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX4 gene
    IRX12  IRX32  IRX52  MKX2  IRX22  IRX62  
    5 SIMAP similar genes for IRX4 using alignment to 5 protein entries:     IRX4_HUMAN (see all proteins):
    IRX2    PKNOX1    TGIF1    IRX6    IRX3

    IRX4 for paralogs           About GeneDecksing



    Genomic Variants
    for IRX4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in IRX4 are shown (see all 163)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1867027701,2
    		--1877098(+) AATAGA/GAGAGC 1 -- int10--------
    rs1144141721,2
    		F,--1877157(+) CTCCTG/ACCTAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1487957301,2
    		--1877177(+) AGGCCA/GCTAAC 1 -- int10--------
    rs113228511,2
    		C,--1877210(+) CCACG-/CCCCCC 1 -- int10--------
    rs1117554131,2
    		C,--1877214(+) GCCCCA/C/TCCCCG 1 -- int10--------
    rs628017601,2
    		C,--1877218(+) CCCCCC/GGGGAC 1 -- int17Minor allele frequency- G:0.15NA CSA WA 246
    rs1823690831,2
    		--1877254(+) AAAATA/CTAATC 1 -- int10--------
    rs1449683821,2
    		--1877257(+) ATCTAA/GTCAAA 1 -- int10--------
    rs49757091,2
    		C,F,A,H,--1877280(+) TTTTCA/CAACTT 1 -- int116Minor allele frequency- C:0.30NS EA CSA WA NA 2336
    rs1866356171,2
    		--1877328(+) CACACC/TCACTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for IRX4 (1877541 - 1887350 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for IRX4
         1 CNV: 68979
         1 Indel: 68978
    Human Gene Mutation Database (HGMD): IRX4

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRX4
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX4

    Disorders / Diseases
    for IRX4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRX4 for disorders           About GeneDecksing

    OMIM gene information: 606199    OMIM disorders: --

    3 diseases for IRX4:    About MalaCards
    hypertrophic cardiomyopathy    cardiomyopathy    migraine

    Human Genome Epidemiology (HuGE) Navigator: IRX4 (5 documents)

    Export disorders for IRX4 gene to outside databases

    Publications
    for IRX4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX4 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with IRX4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. (PubMed id 10625552)1, 2, 3, 9 Bruneau B.G.... Seidman C.E. (2000)
    2. Irx4 forms an inhibitory complex with the vitamin D and retinoic X receptors to regulate cardiac chamber-specific slow MyHC3 expression. (PubMed id 11382777)1, 9 Wang G.F....Stockdale F.E. (2001)
    3. IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer susceptibil ity. (PubMed id 22323358)1 Nguyen H.H....Nakagawa H. (2012)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Genetic determinants of cardiovascular events among w omen with migraine: a genome-wide association study. (PubMed id 21779381)1 SchA1rks M....Kurth T. (2011)
    6. Two novel mutations of the IRX4 gene in patients with congenital heart disease. (PubMed id 21544582)1 Cheng Z....Ma X. (2011)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy. (PubMed id 18497553)1 Bayrak F....Erginel-Unaltuna N. (2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for IRX4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IRX4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50805 HGNC: 6129 AceView: IRX4 Ensembl:ENSG00000113430 euGenes: HUgn50805
    ECgene: IRX4 H-InvDB: IRX4

    Other Databases showing IRX4 gene

    (According to HUGE)
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    Specialized Databases showing IRX4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRX4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IRX4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for IRX4 gene:
    Search GeneIP for patents involving IRX4

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