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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX3 Gene

protein-coding   GIFtS: 49
GCID: GC16M054372

iroquois homeobox 3
 Explore 6 diseases affiliated with
IRX3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRX3    

Aliases
for IRX3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Iroquois Homeobox 31 2     Iroquois Homeobox Protein 32 3
IRXB12 3 5     Iroquois-Class Homeodomain Protein IRX-12
IRX-11 2     Iroquois-Class Homeodomain Protein IRX-32
Homeodomain Protein IRXB12 3     

External Ids:    HGNC: 143601   Entrez Gene: 791912   Ensembl: ENSG000001775087   OMIM: 6129855   UniProtKB: P784153   

Export aliases for IRX3 gene to outside databases

Previous GC identifers: GC16M044731 GC16M054055 GC16M054095 GC16M052874 GC16M040203


Summaries
for IRX3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRX3:
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of
neural development (Bellefroid et al., 1998 (PubMed 9427753)). Members of this family appear to play multiple roles
during pattern formation of vertebrate embryos (Lewis et al., 1999 (PubMed 10370142)).(supplied by OMIM, Aug 2009)

UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415
Function: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to
restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins
of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1
in non-motor neuron cells (By similarity)

Gene Wiki entry for IRX3


Genomic Views
for IRX3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX3 gene promoter:
         ER-alpha   C/EBPbeta   Pax-5   Olf-1   FOXD1   AP-2gamma   E47   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IRX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

IRX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M054372:  view genomic region     (about GC identifiers)

Start:
 54,317,212 bp from pter      End:
 54,320,675 bp from pter
Size:
 3,464 bases      Orientation:
 minus strand

Proteins
for IRX3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-3  
Size: 501 amino acids; 52119 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q7Z4A4 Q7Z4A5 Q8IVC6

Explore the universe of human proteins at neXtProt for IRX3: NX_P78415

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P78415

    • IRX3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_077312.2  
    ENSEMBL proteins: 
     ENSP00000331608   ENSP00000463991   ENSP00000462244  

    Human Recombinant Protein Products: 
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    Novus Biologicals IRX3 Proteins
    Novus Biologicals IRX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRX3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030424axon IEA--


    IRX3 for ontologies           About GeneDecksing



    IRX3 Antibody Products: 
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    Uscn Antibodies for IRX3
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    Uscn ELISAs and CLIAs for IRX3

    Protein Domains /
    Families
    for IRX3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRX3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003893 Iroquois_homeo
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR008422 Homeobox_KN_domain

    Graphical View of Domain Structure for InterPro Entry P78415

    ProtoNet protein and cluster: P78415

    1 Blocks protein family: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for IRX3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415
    Function: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to
    restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins
    of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1
    in non-motor neuron cells (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: IRX3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX3:
    hsa-miR-659 hsa-miR-493* hsa-miR-377 hsa-miR-520g hsa-miR-3121-3p hsa-let-7f-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmid: IRX3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX3 (see all 7)
    OriGene shRNA RFP: IRX3
    OriGene siRNA: IRX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRX3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRX3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRX3
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IRX3 (NM_024336)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IRX3
    Search LifeMap BioReagents cell lines for IRX3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    IRX3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for IRX3:
     Increased cell number in S and 

    Animal Models:
         Mouse knock-out Irx3tm3.1Hui for IRX3
         3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Irx3):
     cardiovascular system  mortality/aging  no phenotypic analysis 

    IRX3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRX3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX3

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007498mesoderm development IEA--
    GO:0045665negative regulation of neuron differentiation IEA--
    GO:0045666positive regulation of neuron differentiation IEA--


    IRX3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRX3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX3
    Search CenterWatch for drugs/clinical trials and news about IRX3 

    Transcripts
    for IRX3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRX3 gene: 
    NM_024336.2  

    Unigene Cluster for IRX3:

    Iroquois homeobox 3
    Hs.499205  [show with all ESTs]
    Unigene Representative Sequence: AY335943
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329734(uc002eht.1) ENST00000558054 ENST00000558180

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX3:
    hsa-miR-659 hsa-miR-493* hsa-miR-377 hsa-miR-520g hsa-miR-3121-3p hsa-let-7f-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmid: IRX3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX3 (see all 7)
    OriGene shRNA RFP: IRX3
    OriGene siRNA: IRX3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX3
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRX3
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    GenScript: all cDNA clones in your preferred vector: IRX3 (NM_024336)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRX3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX3

    Additional cDNA sequence: 

    AY335943.1 BC023667.2 BC034328.1 U90308.1 

    6 DOTS entries:

    DT.75100306  DT.75102193  DT.99986526  DT.91787742  DT.92476549  DT.307304 

    24/50 AceView cDNA sequences (see all 50):

    AI590287 R55184 NM_024336 AA814147 BQ896753 AI796872 AY335943 BC023667 
    BG703129 BE672611 BV174519 AI308059 AI480008 CF541045 BU860344 AI217994 
    AI492375 BI113748 BU624276 CB241853 AA722404 CK822839 D11718 BC034328 

    GeneLoc Exon Structure


    Expression
    for IRX3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCGTGTATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRX3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/19 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 19) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyS-shaped Body Medial SegmentS-shaped Body Medial CellsKidney
    Spinal CordV0 Neural Progenitor DomainV0 Neural Progenitor CellsMotor Neurons
    Spinal CordV1 Neural Progenitor DomainV1 Neural Progenitor CellsMotor Neurons
    Spinal CordV2 Neural Progenitor DomainV2 InterneuronsMotor Neurons
    Spinal CordV2 Neural Progenitor DomainV2 Neural Progenitor CellsMotor Neurons
    Spinal CordMotor Neural Progenitor DomainMotor Neural Progenitor CellsMotor Neurons
    HeartOuter CurvatureCardiomyocytesMyocardium
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LungLung BudDistal Lung Progenitor CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/16 LifeMap Cells (see all 16) 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    GABA neuron-like cells (Generation of motor ...)Brain
    Motor neuron progenitors (Differentiation of ...)

    See IRX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRX3

    SOURCE GeneReport for Unigene cluster: Hs.499205
        SABiosciences Expression via Pathway-Focused PCR Arrays including IRX3: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX3

    Orthologs
    for IRX3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IRX3 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NHU5_CHICK6
    		 Uncharacterized protein
    		 91(a)
    		 possible ortholog
    		 11(3852180-3852389)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.45222 Xenopus laevis homeobox transcription factor iriquois more 80.01(n)    AF027175.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii iro32 iroquois homeobox protein 3 76.61(n)   30520  AF340184.1 


    ENSEMBL Gene Tree for IRX3 (if available)
    TreeFam Gene Tree for IRX3 (if available) 

    Paralogs
    for IRX3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX3 gene
    IRX12  IRX52  MKX2  IRX22  IRX62  IRX42  
    6 SIMAP similar genes for IRX3 using alignment to 4 protein entries:     IRX3_HUMAN (see all proteins):
    IRX2    TGIF1    IRX5    IRX1    IRX4    IRX6

    IRX3 for paralogs           About GeneDecksing



    Genomic Variants
    for IRX3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/90 NCBI SNPs in IRX3 are shown (see all 90)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1500437471,2
    		--54316747(+) TCTTAC/TAGGTA 1 -- ds50010--------
    rs1443283711,2
    		C,--54316783(+) GATCA-/AAGAATGG 1 -- ds50010--------
    rs620328581,2
    		C,F,--54316914(+) TTGCTC/TCCGTA 1 -- ds50017Minor allele frequency- T:0.15NA WA 248
    rs620328591,2
    		C,F,--54316920(+) CCGTAG/CACAAG 1 -- ds50014Minor allele frequency- C:0.19NA 126
    rs1443306281,2
    		--54316946(+) TTCCCA/GGCTCT 1 -- ds50010--------
    rs1488085821,2
    		--54317074(+) GCCTCC/TTCAGC 1 -- ds50010--------
    rs1424564951,2
    		--54317231(+) AGTGGA/CAGCAG 1 -- ut310--------
    rs22788101,2
    		C,--54317259(-) AGTATC/ATATTT 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1513140161,2
    		--54317269(+) TTTCTC/TGTACA 1 -- ut310--------
    rs736277471,2
    		C,--54317275(+) GTACAG/ATTTGG 1 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for IRX3 (54317212 - 54320675 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IRX3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRX3
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX3

    Disorders / Diseases
    for IRX3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRX3 for disorders           About GeneDecksing

    OMIM gene information: 612985    OMIM disorders: --

    6 diseases for IRX3:    About MalaCards
    astigmatism    squamous cell carcinoma    keratoconus    obesity
    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: IRX3 (2 documents)

    Export disorders for IRX3 gene to outside databases

    Publications
    for IRX3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with IRX3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1 Murea M....Freedman B.I. (2011)
    3. Long-range gene regulation links genomic type 2 diabe tes and obesity risk regions to HHEX, SOX4, and IRX3. (PubMed id 20080751)1 Ragvin A....Becker T.S. (2010)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    7. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1 Lewis M.T.... Daniel C.W. (1999)
    8. Xiro3 encodes a Xenopus homolog of the Drosophila Iro quois genes and functions in neural specification. (PubMed id 9427753)1 Bellefroid E.J....Papalopulu N. (1998)
    9. Multiple cellulose synthase catalytic subunits are required for cellulose synthesis in Arabidopsis. (PubMed id 11148295)9 Taylor N.G....Turner S.R. (2000)
    10. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. (PubMed id 18559491)9 Bennett K.L....Plass C. (2008)

    External Searches for IRX3 gene

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    Genome Databases showing IRX3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79191 HGNC: 14360 AceView: IRX3 Ensembl:ENSG00000177508 euGenes: HUgn79191
    ECgene: IRX3 H-InvDB: IRX3

    Other Databases showing IRX3 gene

    (According to HUGE)
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    Specialized Databases showing IRX3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for IRX3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    		Patent Information for IRX3 gene:
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