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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX3 Gene

protein-coding   GIFtS: 50
GCID: GC16M054372

Iroquois Homeobox 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Iroquois Homeobox 31 2     IRX-12
IRXB12 3 5     Iroquois-Class Homeodomain Protein IRX-12
Homeodomain Protein IRXB12 3     Iroquois-Class Homeodomain Protein IRX-32
Iroquois Homeobox Protein 32 3     

External Ids:    HGNC: 143601   Entrez Gene: 791912   Ensembl: ENSG000001775087   OMIM: 6129855   UniProtKB: P784153   

Export aliases for IRX3 gene to outside databases

Previous GC identifers: GC16M044731 GC16M054055 GC16M054095 GC16M052874 GC16M040203


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRX3 Gene:
IRX3 is a member of the Iroquois homeobox gene family (see IRX1; MIM 606197) and plays a role in an early step of
neural development (Bellefroid et al., 1998 (PubMed 9427753)). Members of this family appear to play multiple
roles during pattern formation of vertebrate embryos (Lewis et al., 1999 (PubMed 10370142)).(supplied by OMIM,
Aug 2009)

GeneCards Summary for IRX3 Gene: 
IRX3 (iroquois homeobox 3) is a protein-coding gene. Diseases associated with IRX3 include astigmatism, and keratoconus. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRX1.

UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415
Function: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts
to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I
proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional
repression of MNX1 in non-motor neuron cells (By similarity)

Gene Wiki entry for IRX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX3 gene promoter:
         ER-alpha   C/EBPbeta   Pax-5   Olf-1   FOXD1   AP-2gamma   E47   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IRX3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

IRX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M054372:  view genomic region     (about GC identifiers)

Start:
54,317,212 bp from pter      End:
54,320,675 bp from pter
Size:
3,464 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-3  
Size: 501 amino acids; 52119 Da
Subcellular location: Nucleus (Probable)
Secondary accessions: Q7Z4A4 Q7Z4A5 Q8IVC6

Explore the universe of human proteins at neXtProt for IRX3: NX_P78415

Explore proteomics data for IRX3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78415

  • IRX3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRX3 Protein Expression
    REFSEQ proteins: NP_077312.2  
    ENSEMBL proteins: 
     ENSP00000331608   ENSP00000463991  

    Human Recombinant Protein Products for IRX3: 
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    Novus Biologicals IRX3 Proteins
    Novus Biologicals IRX3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRX3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0030424axon IEA--

    IRX3 for ontologies           About GeneDecksing



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    LSBio Antibodies in human, mouse, rat for IRX3 

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    Cloud-Clone Corp. ELISAs for IRX3 
    Cloud-Clone Corp. CLIAs for IRX3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TALE: Homeoboxes / TALE class

    5 InterPro protein domains:
     IPR003893 Iroquois_homeo
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P78415

    ProtoNet protein and cluster: P78415

    1 Blocks protein domain: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX3_HUMAN, P78415
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    IRX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRX3_HUMAN, P78415
    Function: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts
    to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I
    proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional
    repression of MNX1 in non-motor neuron cells (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    IRX3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for IRX3:
     Increased cell number in S and 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Irx3):
     cardiovascular system  mortality/aging  no phenotypic analysis 

    IRX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irx3tm3.1Hui for IRX3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRX3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRX3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRX3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRX3 

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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX3:
    hsa-miR-659 hsa-miR-493* hsa-miR-377 hsa-miR-520g hsa-miR-3121-3p hsa-let-7f-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidIRX3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of IRX3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX3

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007498mesoderm development IEA--
    GO:0045665negative regulation of neuron differentiation IEA--

    IRX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX3

    Search CenterWatch for drugs/clinical trials and news about IRX3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRX3 gene: 
    NM_024336.2  

    Unigene Cluster for IRX3:

    Iroquois homeobox 3
    Hs.499205  [show with all ESTs]
    Unigene Representative Sequence: AY335943
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329734(uc002eht.1) ENST00000558054 ENST00000558180
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX3:
    hsa-miR-659 hsa-miR-493* hsa-miR-377 hsa-miR-520g hsa-miR-3121-3p hsa-let-7f-2* hsa-miR-1284
    SwitchGear 3'UTR luciferase reporter plasmidIRX3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX3
    Sirion Biotech Customized lentivirus for stable overexpression of IRX3 
                         Customized lentivirus expression plasmids for stable overexpression of IRX3 
    Primer
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    OriGene qPCR primer pairs and template standards for IRX3
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRX3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX3

    Additional mRNA sequence: 

    AY335943.1 BC023667.2 BC034328.1 U90308.1 

    7 DOTS entries:

    DT.75100306  DT.75102193  DT.99986526  DT.91787742  DT.92476549  DT.307304  DT.86840669 

    24/50 AceView cDNA sequences (see all 50):

    AA814147 R55184 NM_024336 BQ896753 AI590287 BC023667 AI796872 AY335943 
    CF541045 AI480008 CK822840 AI479167 BG422895 CA446853 BV174519 D11718 
    CK822839 AI492375 U90308 BG703129 BI113748 BU860344 BC034328 BE672611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX3 expression in normal human tissues (normalized intensities)      IRX3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCGTGTATA
    IRX3 Expression
    About this image


    IRX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Late MN Progenitor Cells Motor Neural Progenitor Domain
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Human Cerebellar Astrocytes   
             Substantia Nigra   
     
     Neural Tube (Nervous System)    fully expand to see all 16 entries
             V2 Neural Progenitor Cells pV2 Neural Domain
             Mesencephalic Ventricular Zone
             spinal cord/lateral wall/mantle layer   
     
     Spinal Cord (Nervous System)    fully expand to see all 7 entries
             Motor Neural Progenitor Cells Motor Neural Progenitor Domain
             Motor neuron progenitors ( Differentiation of mouse neural stem cells into motor...
             Dorsal Horn   
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Growth Plate
             HyStem+BMP4-induced MEL2 cells
             Human Vertebral Mesenchymal Stem Cells (HVMSC)   
             sensory organ/ear/inner ear   
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem progenitor RP1-MV2-8

    See IRX3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRX3

    SOURCE GeneReport for Unigene cluster: Hs.499205
        SABiosciences Expression via Pathway-Focused PCR Arrays including IRX3: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IRX3 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irx31 , 5 Iroquois related homeobox 3 (Drosophila)1, 5 86.83(n)1
    92.22(a)1
      8 (44.55 cM)5
    163731  NM_008393.31  NP_032419.21 
     917985255 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.45222 Xenopus laevis homeobox transcription factor iriquois more 80.01(n)    AF027175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iro32 iroquois homeobox protein 3 76.61(n)   30520  AF340184.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mirr3 positive regulation of transcription
    transcription more
    60(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea irx-16
    Putative iroquois-class homeodomain protein irx-1
    22(a)
    1 → many
    I(9536488-9540968)


    ENSEMBL Gene Tree for IRX3 (if available)
    TreeFam Gene Tree for IRX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX3 gene
    IRX12  IRX52  MKX2  IRX22  IRX62  IRX42  
    4 SIMAP similar genes for IRX3 using alignment to 4 protein entries:     IRX3_HUMAN (see all proteins):
    IRX2    TGIF1    IRX1    IRX4

    IRX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/119 SNPs in IRX3 are shown (see all 119)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500437471,2
    --54316747(+) TCTTAC/TAGGTA 1 -- ds50010--------
    rs1443283711,2
    C--54316783(+) GATCA-/AAGGAATG 1 -- ds50010--------
    rs620328581,2
    C,F--54316914(+) TTGCTC/TCCGTA 1 -- ds50017Minor allele frequency- T:0.15NA WA 248
    rs620328591,2
    C,F--54316920(+) CCGTAG/CACAAG 1 -- ds50014Minor allele frequency- C:0.19NA 126
    rs1443306281,2
    C--54316946(+) TTCCCA/GGCTCT 1 -- ds50010--------
    rs1488085821,2
    --54317074(+) GCCTCC/TTCAGC 1 -- ds50010--------
    rs1424564951,2
    --54317231(+) AGTGGA/CAGCAG 1 -- ut310--------
    rs22788101,2
    C,F--54317259(-) AGTATC/ATATTT 1 -- ut311Minor allele frequency- A:0.00NA 2
    rs1513140161,2
    --54317269(+) TTTCTC/TGTACA 1 -- ut310--------
    rs736277471,2
    C,F--54317275(+) GTACAG/ATTTGG 1 -- ut311Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for IRX3 (54317212 - 54320675 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for IRX3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664461CNV Deletion23128226
    nsv833236CNV Loss17160897
    nsv827655CNV Gain20364138
    nsv833235CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing IRX3
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612985    OMIM disorders: --

    5 diseases for IRX3:    About MalaCards
    astigmatism    keratoconus    obesity    squamous cell carcinoma
    neuronitis


    IRX3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): IRX3
    Human Genome Epidemiology (HuGE) Navigator: IRX3 (2 documents)

    Export disorders for IRX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with IRX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes. (PubMed id 21546767)1, 4 Murea M....Freedman B.I. (2011)
    2. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Long-range gene regulation links genomic type 2 diabe tes and obesity risk regions to HHEX, SOX4, and IRX3. (PubMed id 20080751)1 Ragvin A....Becker T.S. (2010)
    5. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    8. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1 Lewis M.T.... Daniel C.W. (1999)
    9. Xiro3 encodes a Xenopus homolog of the Drosophila Iro quois genes and functions in neural specification. (PubMed id 9427753)1 Bellefroid E.J....Papalopulu N. (1998)
    10. Multiple cellulose synthase catalytic subunits are required for cellulose synthesis in Arabidopsis. (PubMed id 11148295)9 Taylor N.G....Turner S.R. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79191 HGNC: 14360 AceView: IRX3 Ensembl:ENSG00000177508 euGenes: HUgn79191
    ECgene: IRX3 H-InvDB: IRX3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRX3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRX3 gene:
    Search GeneIP for patents involving IRX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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