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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRX2 Gene

protein-coding   GIFtS: 50
GCID: GC05M002745

iroquois homeobox 2
 Explore 8 diseases affiliated with
IRX2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRX2    

Aliases
for IRX2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Iroquois Homeobox 21 2
Homeodomain Protein IRXA22 3
Iroquois Homeobox Protein 22 3
IRXA22 3
Iroquois-Class Homeodomain Protein IRX-22

External Ids:    HGNC: 143591   Entrez Gene: 1535722   Ensembl: ENSG000001705617   OMIM: 6061985   UniProtKB: Q9BZI13   

Export aliases for IRX2 gene to outside databases

Previous GC identifers: GC05U990165 GC05M002901 GC05M002782 GC05M002792 GC05M002799


Summaries
for IRX2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRX2:
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during
pattern formation of vertebrate embryos.(supplied by OMIM, Apr 2004)

Gene Wiki entry for IRX2


Genomic Views
for IRX2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRX2 gene promoter:
         AP-2gamma   c-Ets-1   PPAR-gamma1   POU2F1   POU2F1a   COMP1   AP-2beta   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for IRX2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

IRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M002745:  view genomic region     (about GC identifiers)

Start:
 2,745,959 bp from pter      End:
 2,752,969 bp from pter
Size:
 7,011 bases      Orientation:
 minus strand

Proteins
for IRX2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRX2_HUMAN, Q9BZI1 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-2  
Size: 471 amino acids; 49129 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q68A19 Q7Z2I7

Explore the universe of human proteins at neXtProt for IRX2: NX_Q9BZI1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BZI1

    • IRX2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127694.1  NP_150366.1  

    ENSEMBL proteins: 
     ENSP00000372056   ENSP00000307006   ENSP00000426151  

    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for IRX2 
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    Novus Biologicals IRX2 Protein
    Novus Biologicals IRX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRX2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    IRX2 for ontologies           About GeneDecksing



    IRX2 Antibody Products: 
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    Uscn Antibodies for IRX2
    ThermoFisher Antibodies for IRX2

    Assay Products for IRX2: 
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    Uscn ELISAs and CLIAs for IRX2

    Protein Domains /
    Families
    for IRX2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRX2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003893 Iroquois_homeo
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR008422 Homeobox_KN_domain

    Graphical View of Domain Structure for InterPro Entry Q9BZI1

    ProtoNet protein and cluster: Q9BZI1

    1 Blocks protein family: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX2_HUMAN, Q9BZI1
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for IRX2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): IRX2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX2 (see all 31):
    hsa-miR-132* hsa-miR-607 hsa-miR-448 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-539 hsa-miR-3616-5p hsa-miR-1245
    SwitchGear 3'UTR luciferase reporter plasmid: IRX2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX2 (see all 7)
    OriGene shRNA RFP: IRX2
    OriGene siRNA: IRX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRX2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRX2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRX2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): IRX2 (NM_033267)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IRX2
    Search LifeMap BioReagents cell lines for IRX2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    IRX2 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Irx2):
     normal 

    IRX2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRX2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRX2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for IRX2 (Q9BZI13 ENSP000003070064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MAPK1P284823I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development ----
    GO:0072086specification of loop of Henle identity IEA--
    GO:0072272proximal/distal pattern formation involved in metanephric nephron development IEA--


    IRX2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRX2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRX2
    Search CenterWatch for drugs/clinical trials and news about IRX2 

    Transcripts
    for IRX2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRX2 gene (2 alternative transcripts): 
    NM_001134222.1  NM_033267.4  

    Unigene Cluster for IRX2:

    Iroquois homeobox 2
    Hs.282089  [show with all ESTs]
    Unigene Representative Sequence: NM_033267
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382611(uc003jda.3) ENST00000302057(uc003jdb.3) ENST00000502957


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): IRX2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRX2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate IRX2 (see all 31):
    hsa-miR-132* hsa-miR-607 hsa-miR-448 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-539 hsa-miR-3616-5p hsa-miR-1245
    SwitchGear 3'UTR luciferase reporter plasmid: IRX2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRX2 (see all 7)
    OriGene shRNA RFP: IRX2
    OriGene siRNA: IRX2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRX2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRX2 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRX2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): IRX2 (NM_033267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRX2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRX2

    Additional cDNA sequence: 

    AB188492.1 AY335940.1 BC065189.1 

    6 DOTS entries:

    DT.102826027  DT.100661439  DT.447969  DT.40251890  DT.75167750  DT.86855178 

    24/65 AceView cDNA sequences (see all 65):

    AY335940 BC065189 AA988053 W60176 H88261 BM662838 CK820280 BQ286634 
    AW673586 BM969863 BQ269977 BM142505 BM687945 BM662064 BM352059 AW731734 
    CK821213 BM142541 H88050 AI613079 AI131378 BI962618 CK821212 AI654035 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IRX2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                                            -                           
    SP2:                                            -     -                     
    SP3:                                            -                           
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for IRX2

    Expression
    for IRX2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCAAGTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRX2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartOuter CurvatureCardiomyocytesMyocardium
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LungLung BudDistal Lung Progenitor CellsLung
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See IRX2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRX2

    SOURCE GeneReport for Unigene cluster: Hs.282089
        SABiosciences Custom PCR Arrays for IRX2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX2

    Orthologs
    for IRX2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IRX2 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IRX21 iroquois homeobox 2 78.92(n)
    79.43(a)    		   373975  NM_001030336.1  NP_001025507.1 
    lizard
    (Anolis carolinensis)    		 Reptilia IRX26
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343292.1(1436673-1445577)
    African clawed frog
    (Xenopus laevis)    		 Amphibia irx2-A2 homeobox Iroquois protein 2 78.07(n)    AJ001835.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc658722 similar to Iroquois related homeobox 2 (Drosophila) 76.14(n)   394032  BC056322.1 


    ENSEMBL Gene Tree for IRX2 (if available)
    TreeFam Gene Tree for IRX2 (if available) 

    Paralogs
    for IRX2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRX2 gene
    IRX12  IRX32  IRX52  MKX2  IRX62  IRX42  
    6 SIMAP similar genes for IRX2 using alignment to 2 protein entries:     IRX2_HUMAN (see all proteins):
    PKNOX1    IRX4    IRX3    IRX5    TGIF1    IRX1

    IRX2 for paralogs           About GeneDecksing



    Genomic Variants
    for IRX2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 NCBI SNPs in IRX2 are shown (see all 93)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1817112561,2
    		--2745824(+) TTCAGC/GCTTTA 2 -- int10--------
    rs1869306671,2
    		--2745867(+) GGTGGA/GGGGGT 2 -- int10--------
    rs1460196351,2
    		--2745962(+) CATAGA/GGTGTC 2 -- int10--------
    rs1912958071,2
    		--2746072(+) CTGTAG/TAGAAA 2 -- int10--------
    rs1116104921,2
    		C,--2746091(+) AGCACAT/-GTTTC 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs15407091,2
    		C,F,A,H,--2746229(-) AGAGCT/GCTAGT 2 -- int1 ese322Minor allele frequency- G:0.39NS EA WA NA CSA 2347
    rs1399830141,2
    		--2746257(+) TAGGAA/CAAATA 2 -- int10--------
    rs1814770121,2
    		--2746336(+) GAATTC/TGTGTT 2 -- ut310--------
    rs1862119921,2
    		--2746395(+) GGCAGA/CATTTA 2 -- ut310--------
    rs1898790321,2
    		--2746421(+) GATTCC/TATTGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IRX2 (2745959 - 2752969 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for IRX2: --

    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing IRX2:
    WNT Signaling
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRX2
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX2

    Disorders / Diseases
    for IRX2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRX2 for disorders           About GeneDecksing

    OMIM gene information: 606198    OMIM disorders: --

    8 diseases for IRX2:    About MalaCards
    soft tissue sarcoma    squamous cell carcinoma of the head and neck    squamous cell carcinoma    myopia
    cervical carcinoma    sarcoma    cervicitis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: IRX2 (1 document)

    Export disorders for IRX2 gene to outside databases

    Publications
    for IRX2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRX2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with IRX2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PubMed id 11435706)1, 2, 3 Ogura K.... Ogura T. (2001)
    2. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1, 9 Lewis M.T.... Daniel C.W. (1999)
    3. Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study. (PubMed id 22210879)1 Kang H....Willman C.L. (2012)
    4. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    5. A Genome-wide Scan Maps a Novel High Myopia Locus to 5p15. (PubMed id 18421076)1 Lam C.Y....Lam D.S. (2008)
    6. Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. (PubMed id 16752383)1 Adamowicz M....Joos S. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. (PubMed id 15133517)1 Matsumoto K....Ogura T. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for IRX2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing IRX2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 153572 HGNC: 14359 AceView: IRX2 Ensembl:ENSG00000170561 euGenes: HUgn153572
    ECgene: IRX2 H-InvDB: IRX2

    Other Databases showing IRX2 gene

    (According to HUGE)
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    Specialized Databases showing IRX2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRX2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for IRX2 gene:
    Search GeneIP for patents involving IRX2

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