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IRX2 Gene

protein-coding   GIFtS: 51
GCID: GC05M002745

Iroquois Homeobox 2

  See IRX2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Iroquois Homeobox 21 2
Homeodomain Protein IRXA22 3
Iroquois Homeobox Protein 22 3
IRXA22 3
Iroquois-Class Homeodomain Protein IRX-22

External Ids:    HGNC: 143591   Entrez Gene: 1535722   Ensembl: ENSG000001705617   OMIM: 6061985   UniProtKB: Q9BZI13   

Export aliases for IRX2 gene to outside databases

Previous GC identifers: GC05U990165 GC05M002901 GC05M002782 GC05M002792 GC05M002799


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRX2 Gene:
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during
pattern formation of vertebrate embryos.(supplied by OMIM, Apr 2004)

GeneCards Summary for IRX2 Gene:
IRX2 (iroquois homeobox 2) is a protein-coding gene. Diseases associated with IRX2 include soft tissue sarcoma, and squamous cell carcinoma of the head and neck. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRX1.

Gene Wiki entry for IRX2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRX2 gene promoter:
         AP-2gamma   c-Ets-1   PPAR-gamma1   POU2F1   POU2F1a   COMP1   AP-2beta   PPAR-gamma2   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IRX2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRX2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

IRX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRX2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M002745:  view genomic region     (about GC identifiers)

Start:
2,745,959 bp from pter      End:
2,752,969 bp from pter
Size:
7,011 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IRX2_HUMAN, Q9BZI1 (See protein sequence)
Recommended Name: Iroquois-class homeodomain protein IRX-2  
Size: 471 amino acids; 49129 Da
Secondary accessions: Q68A19 Q7Z2I7

Explore the universe of human proteins at neXtProt for IRX2: NX_Q9BZI1

Explore proteomics data for IRX2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRX2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127694.1  NP_150366.1  

    ENSEMBL proteins: 
     ENSP00000372056   ENSP00000307006  

    IRX2 Human Recombinant Protein Products:

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    Novus Biologicals IRX2 Protein
    Novus Biologicals IRX2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRX2

     
    Search eBioscience for Proteins for IRX2 

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    Cloud-Clone Corp. ELISAs for IRX2
    Cloud-Clone Corp. CLIAs for IRX2
    Search eBioscience for ELISAs for IRX2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TALE: Homeoboxes / TALE class

    5 InterPro protein domains:
     IPR003893 Iroquois_homeo
     IPR008422 Homeobox_KN_domain
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q9BZI1

    ProtoNet protein and cluster: Q9BZI1

    1 Blocks protein domain: IPB003893 Iroquois-class homeodomain protein

    UniProtKB/Swiss-Prot: IRX2_HUMAN, Q9BZI1
    Similarity: Belongs to the TALE/IRO homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with IRX2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with IRX2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Irx2):
     normal 

    Find genes that share phenotypes with IRX2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRX2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRX2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRX2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRX2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRX2:
    hsa-mir-335-5p (MIRT017070)

    Block miRNA regulation of human, mouse, rat IRX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRX2 (see all 31):
    hsa-miR-132* hsa-miR-607 hsa-miR-448 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-539 hsa-miR-3616-5p hsa-miR-1245
    SwitchGear 3'UTR luciferase reporter plasmidIRX2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat IRX2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): IRX2 (NM_033267)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX2

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    Browse ESI BIO Cell Lines and PureStem Progenitors for IRX2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRX2_HUMAN, Q9BZI1: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with IRX2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for IRX2
    Interactions:

        Search GeneGlobe Interaction Network for IRX2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for IRX2 (Q9BZI13 ENSP000003070064) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MAPK1P284823I2D: score=1 
    LFNGENSP000002227254STRING: ENSP00000222725
    MFNGENSP000003494904STRING: ENSP00000349490
    RFNGENSP000003079714STRING: ENSP00000307971
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0072086specification of loop of Henle identity IEA--
    GO:0072272proximal/distal pattern formation involved in metanephric nephron development IEA--

    Find genes that share ontologies with IRX2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRX2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRX2 gene (2 alternative transcripts): 
    NM_001134222.1  NM_033267.4  

    Unigene Cluster for IRX2:

    Iroquois homeobox 2
    Hs.282089  [show with all ESTs]
    Unigene Representative Sequence: NM_033267
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382611(uc003jda.3) ENST00000302057(uc003jdb.3) ENST00000502957

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRX2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRX2 (see all 31):
    hsa-miR-132* hsa-miR-607 hsa-miR-448 hsa-miR-520d-5p hsa-miR-4251 hsa-miR-539 hsa-miR-3616-5p hsa-miR-1245
    SwitchGear 3'UTR luciferase reporter plasmidIRX2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for IRX2
    Predesigned siRNA for gene silencing in human, mouse, rat IRX2
    Clone
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    OriGene clones in human, mouse for IRX2 (see all 11)
    OriGene ORF clones in mouse, rat for IRX2
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    GenScript: all cDNA clones in your preferred vector (see all 2): IRX2 (NM_033267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRX2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRX2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IRX2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRX2
      QuantiTect SYBR Green Assays in human, mouse, rat IRX2
      QuantiFast Probe-based Assays in human, mouse, rat IRX2

    Additional mRNA sequence: 

    AB188492.1 AY335940.1 BC065189.1 

    6 DOTS entries:

    DT.102826027  DT.100661439  DT.447969  DT.40251890  DT.75167750  DT.86855178 

    Selected AceView cDNA sequences (see all 65):

    AA988053 AY335940 AW673586 AI613079 BM142541 BQ269977 W60176 BQ286634 
    BM687945 BM662064 CK820280 H88261 AW731734 BM969863 BM142505 BC065189 
    H88050 BM352059 AI131378 BM662838 CK821213 BI962618 BQ067529 BI789145 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for IRX2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
    SP1:                                            -                           
    SP2:                                            -     -                     
    SP3:                                            -                           
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for IRX2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRX2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAGTGGA
    IRX2 Expression
    About this image


    IRX2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
     
     Heart (Cardiovascular System)
             Cardiomyocytes Outer Curvature
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             Distal Lung Progenitor Cells Lung Bud
             Stem Bronchi
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Limb Bud Mesenchyme Cells Limb Bud
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    IRX2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRX2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282089
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRX2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for IRX2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irx21 , 5 Iroquois related homeobox 2 (Drosophila)1, 5 88.18(n)1
    92.14(a)1
      13 (39.23 cM)5
    163721  NM_010574.21  NP_034704.11 
     726288205 
    chicken
    (Gallus gallus)
    Aves IRX21 iroquois homeobox 2 78.02(n)
    76.64(a)
      373975  NM_001030336.1  NP_001025507.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRX26
    iroquois homeobox 2
    72(a)
    1 ↔ 1
    GL343292.1(1435787-1449574)
    African clawed frog
    (Xenopus laevis)
    Amphibia irx2-A2 homeobox Iroquois protein 2 78.07(n)    AJ001835.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc658722 similar to Iroquois related homeobox 2 (Drosophila) 76.14(n)   394032  BC056322.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mirr6
    mirror
    22(a)
    1 → many
    3L(12686739-12703243)


    ENSEMBL Gene Tree for IRX2 (if available)
    TreeFam Gene Tree for IRX2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRX2 gene
    IRX12  IRX32  IRX52  MKX2  IRX62  IRX42  
    2 SIMAP similar genes for IRX2 using alignment to 1 protein entry:     IRX2_HUMAN:
    IRX5    TGIF1

    Find genes that share paralogs with IRX2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRX2 (see all 103)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817112561,2
    C--2745824(+) TTCAGC/GCTTTA 2 -- int10--------
    rs1869306671,2
    --2745867(+) GGTGGA/GGGGGT 2 -- int10--------
    rs1460196351,2
    --2745962(+) CATAGA/GGTGTC 2 -- int10--------
    rs1912958071,2
    --2746072(+) CTGTAG/TAGAAA 2 -- int10--------
    rs1116104921,2
    C--2746091(+) AGCACAT/-GTTTC 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs15407091,2
    C,F,A,H--2746229(-) AGAGCT/GCTAGT 2 -- int1 ese322Minor allele frequency- G:0.39NS EA WA NA CSA 2347
    rs1399830141,2
    --2746257(+) TAGGAA/CAAATA 2 -- int10--------
    rs1814770121,2
    --2746336(+) GAATTC/TGTGTT 2 -- ut310--------
    rs1862119921,2
    --2746395(+) GGCAGA/CATTTA 2 -- ut310--------
    rs1898790321,2
    --2746421(+) GATTCC/TATTGC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for IRX2 (2745959 - 2752969 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IRX2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv461913CNV Loss19166990
    nsv822977CNV Gain20364138
    nsv822975CNV Gain20364138
    dgv931n67CNV Gain20364138
    nsv822972CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing IRX2:
    WNT Signaling
    SeqTarget long-range PCR primers for resequencing IRX2
    DNA2.0 Custom Variant and Variant Library Synthesis for IRX2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606198    OMIM disorders: --

    2 diseases for IRX2:    
    About MalaCards
    soft tissue sarcoma    squamous cell carcinoma of the head and neck


    Find genes that share disorders with IRX2           About GenesLikeMe

    Genetic Association Database (GAD): IRX2
    Human Genome Epidemiology (HuGE) Navigator: IRX2 (1 document)

    Export disorders for IRX2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRX2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with IRX2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PubMed id 11435706)1, 2, 3 Ogura K.... Ogura T. (Cytogenet. Cell Genet. 2001)
    2. A genome-wide scan maps a novel high myopia locus to 5p15. (PubMed id 18421076)1, 4 Lam C.Y....Lam D.S. (amp 2008)
    3. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PubMed id 10370142)1, 9 Lewis M.T.... Daniel C.W. (Cell Tissue Res. 1999)
    4. Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study. (PubMed id 22210879)1 Kang H....Willman C.L. (Blood 2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. (PubMed id 16752383)1 Adamowicz M....Joos S. (amp 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation. (PubMed id 15133517)1 Matsumoto K....Ogura T. (Nat. Neurosci. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 153572 HGNC: 14359 AceView: IRX2 Ensembl:ENSG00000170561 euGenes: HUgn153572
    ECgene: IRX2 H-InvDB: IRX2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRX2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IRX2 gene:
    Search GeneIP for patents involving IRX2

    GeneCards and IP:
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