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Aliases for IRX2 Gene

Aliases for IRX2 Gene

  • Iroquois Homeobox 2 2 3
  • Iroquois Homeobox Protein 2 3 4
  • Homeodomain Protein IRXA2 3 4
  • IRXA2 3 4
  • Iroquois-Class Homeodomain Protein IRX-2 3

External Ids for IRX2 Gene

Previous GeneCards Identifiers for IRX2 Gene

  • GC05U990165
  • GC05M002901
  • GC05M002782
  • GC05M002792
  • GC05M002799

Summaries for IRX2 Gene

Entrez Gene Summary for IRX2 Gene

  • IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]

GeneCards Summary for IRX2 Gene

IRX2 (Iroquois Homeobox 2) is a Protein Coding gene. Diseases associated with IRX2 include soft tissue sarcoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IRX3.

Gene Wiki entry for IRX2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX2 Gene

Genomics for IRX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRX2 Gene

2,745,845 bp from pter
2,751,662 bp from pter
5,818 bases
Minus strand

Genomic View for IRX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX2 Gene

Proteins for IRX2 Gene

  • Protein details for IRX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iroquois-class homeodomain protein IRX-2
    Protein Accession:
    Secondary Accessions:
    • Q68A19
    • Q7Z2I7

    Protein attributes for IRX2 Gene

    471 amino acids
    Molecular mass:
    49129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX2 Gene

Proteomics data for IRX2 Gene at MOPED

Post-translational modifications for IRX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX2 Gene

Domains for IRX2 Gene

Gene Families for IRX2 Gene

  • TALE :Homeoboxes / TALE class

Suggested Antigen Peptide Sequences for IRX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZI1
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX2: view

Function for IRX2 Gene

Gene Ontology (GO) - Molecular Function for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX2: view

Phenotypes for IRX2 Gene

MGI mutant phenotypes for IRX2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with IRX2: view

Animal Model Products

CRISPR Products

miRNA for IRX2 Gene

miRTarBase miRNAs that target IRX2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRX2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for IRX2 Gene

Localization for IRX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX2 Gene

Subcellular locations from

Jensen Localization Image for IRX2 Gene COMPARTMENTS Subcellular localization image for IRX2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX2: view

Pathways for IRX2 Gene

SuperPathways for IRX2 Gene

No Data Available

Interacting Proteins for IRX2 Gene

Gene Ontology (GO) - Biological Process for IRX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0072086 specification of loop of Henle identity IEA --
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA --
genes like me logo Genes that share ontologies with IRX2: view

No data available for Pathways by source for IRX2 Gene

Transcripts for IRX2 Gene

mRNA/cDNA for IRX2 Gene

Unigene Clusters for IRX2 Gene

Iroquois homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRX2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IRX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRX2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: -

Relevant External Links for IRX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRX2 Gene

mRNA expression in normal human tissues for IRX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (8.2), Minor Salivary Gland (7.9), Skin - Sun Exposed (Lower leg) (6.3), Breast - Mammary Tissue (5.1), and Lung (4.0).

SOURCE GeneReport for Unigene cluster for IRX2 Gene Hs.282089

genes like me logo Genes that share expressions with IRX2: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for IRX2 Gene

Orthologs for IRX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRX2 35
  • 99.65 (n)
  • 99.79 (a)
IRX2 36
  • 100 (a)
(Bos Taurus)
Mammalia IRX2 36
  • 93 (a)
(Canis familiaris)
Mammalia IRX2 35
  • 93.62 (n)
  • 96.6 (a)
IRX2 36
  • 96 (a)
(Mus musculus)
Mammalia Irx2 35
  • 88.18 (n)
  • 92.14 (a)
Irx2 16
Irx2 36
  • 92 (a)
(Monodelphis domestica)
Mammalia IRX2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia IRX2 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Irx2 35
  • 88.68 (n)
  • 92.99 (a)
(Gallus gallus)
Aves IRX2 35
  • 78.02 (n)
  • 76.64 (a)
IRX2 36
  • 74 (a)
(Anolis carolinensis)
Reptilia IRX2 36
  • 72 (a)
African clawed frog
(Xenopus laevis)
Amphibia irx2-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia irx2 35
  • 69.42 (n)
  • 75.67 (a)
Str.7073 35
(Danio rerio)
Actinopterygii irx2a 35
  • 69.34 (n)
  • 71.23 (a)
irx2a 36
  • 71 (a)
zgc65872 35
fruit fly
(Drosophila melanogaster)
Insecta mirr 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for IRX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX2 Gene

Gene Tree for IRX2 (if available)
Gene Tree for IRX2 (if available)

Paralogs for IRX2 Gene

Paralogs for IRX2 Gene

Selected SIMAP similar genes for IRX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX2: view

Variants for IRX2 Gene

Sequence variations from dbSNP and Humsavar for IRX2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10167 -- 2,747,470(+) AGCAA(A/G)AAAAA intron-variant, utr-variant-3-prime
rs11432 -- 2,747,013(+) GTTGG(A/G)CAGGG intron-variant, utr-variant-3-prime
rs1055365 -- 2,747,321(+) TATAT(A/T)TTTTT intron-variant, utr-variant-3-prime
rs1540709 -- 2,746,115(-) AGAGC(G/T)CTAGT downstream-variant-500B
rs2935601 -- 2,747,870(-) GTTCG(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRX2 Gene

Variant ID Type Subtype PubMed ID
dgv931n67 CNV Gain 20364138
nsv822972 CNV Gain 20364138
nsv461913 CNV Loss 19166990
nsv822975 CNV Gain 20364138
nsv822977 CNV Gain 20364138

Relevant External Links for IRX2 Gene

HapMap Linkage Disequilibrium report

PCR Panel Products

  • Copy Number PCR Panels: for IRX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX2 Gene

Disorders for IRX2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for IRX2 Gene including...

Search for IRX2 Gene in MalaCards »

Relevant External Links for IRX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with IRX2: view

No data available for UniProtKB/Swiss-Prot for IRX2 Gene

Publications for IRX2 Gene

  1. Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes. (PMID: 11435706) Ogura K. … Ogura T. (Cytogenet. Cell Genet. 2001) 2 3 4
  2. A genome-wide scan maps a novel high myopia locus to 5p15. (PMID: 18421076) Lam C.Y. … Lam D.S. (Invest. Ophthalmol. Vis. Sci. 2008) 3 48
  3. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast. (PMID: 10370142) Lewis M.T. … Daniel C.W. (Cell Tissue Res. 1999) 3 23
  4. Combination immunotherapy of squamous cell carcinoma of the head and neck: a phase 2 trial. (PMID: 10722007) Barrera J.L. … Hadden J.W. (Arch. Otolaryngol. Head Neck Surg. 2000) 23
  5. A pilot study of perilymphatic leukocyte cytokine mixture (IRX-2) as neoadjuvant treatment for early stage cervical carcinoma. (PMID: 12188025) DueA+as-Gonzalez A. … Hadden J.W. (Int. Immunopharmacol. 2002) 23

Products for IRX2 Gene

Sources for IRX2 Gene

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