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Aliases for IRX1 Gene

Aliases for IRX1 Gene

  • Iroquois Homeobox 1 2 3
  • Iroquois Homeobox Protein 1 3 4
  • Homeodomain Protein IRXA1 3 4
  • IRXA1 3 4
  • Iroquois-Class Homeodomain Protein IRX-1 3
  • IRX-5 3

External Ids for IRX1 Gene

Summaries for IRX1 Gene

Entrez Gene Summary for IRX1 Gene

  • This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

GeneCards Summary for IRX1 Gene

IRX1 (Iroquois Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IRX3.

Gene Wiki entry for IRX1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX1 Gene

Genomics for IRX1 Gene

Genomic Location for IRX1 Gene

Start:
3,596,054 bp from pter
End:
3,601,403 bp from pter
Size:
5,350 bases
Orientation:
Plus strand

Genomic View for IRX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX1 Gene

Regulatory Elements for IRX1 Gene

Proteins for IRX1 Gene

  • Protein details for IRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78414-IRX1_HUMAN
    Recommended name:
    Iroquois-class homeodomain protein IRX-1
    Protein Accession:
    P78414
    Secondary Accessions:
    • Q7Z2F8
    • Q8N312

    Protein attributes for IRX1 Gene

    Size:
    480 amino acids
    Molecular mass:
    49621 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX1 Gene

Proteomics data for IRX1 Gene at MOPED

Post-translational modifications for IRX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX1 Gene

Domains for IRX1 Gene

Gene Families for IRX1 Gene

HGNC:
  • TALE :Homeoboxes / TALE class

Suggested Antigen Peptide Sequences for IRX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P78414

UniProtKB/Swiss-Prot:

IRX1_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P78414
Family:
  • Belongs to the TALE/IRO homeobox family.:
    • P78414
genes like me logo Genes that share domains with IRX1: view

Function for IRX1 Gene

Gene Ontology (GO) - Molecular Function for IRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IRX1 Gene

Localization for IRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRX1 Gene COMPARTMENTS Subcellular localization image for IRX1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX1: view

Pathways for IRX1 Gene

SuperPathways for IRX1 Gene

No Data Available

Interacting Proteins for IRX1 Gene

Gene Ontology (GO) - Biological Process for IRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001656 metanephros development --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0072086 specification of loop of Henle identity IEA --
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA --
genes like me logo Genes that share ontologies with IRX1: view

No data available for Pathways by source for IRX1 Gene

Transcripts for IRX1 Gene

mRNA/cDNA for IRX1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRX1 Gene

Iroquois homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRX1 Gene

No ASD Table

Relevant External Links for IRX1 Gene

GeneLoc Exon Structure for
IRX1
ECgene alternative splicing isoforms for
IRX1

Expression for IRX1 Gene

mRNA expression in normal human tissues for IRX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX1 Gene

This gene is overexpressed in Minor Salivary Gland (9.6), Breast - Mammary Tissue (8.1), Kidney - Cortex (6.4), and Skin - Sun Exposed (Lower leg) (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IRX1 Gene

SOURCE GeneReport for Unigene cluster for IRX1 Gene Hs.424156

genes like me logo Genes that share expressions with IRX1: view

No data available for mRNA Expression by UniProt/SwissProt for IRX1 Gene

Orthologs for IRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRX1 35
  • 99.57 (n)
  • 99.79 (a)
IRX1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRX1 35
  • 88.02 (n)
  • 91.97 (a)
IRX1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRX1 35
  • 86.3 (n)
  • 89.66 (a)
IRX1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irx1 35
  • 85.9 (n)
  • 91.46 (a)
Irx1 16
Irx1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRX1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRX1 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irx1 35
  • 85.97 (n)
  • 90.42 (a)
chicken
(Gallus gallus)
Aves IRX1 35
  • 71.61 (n)
  • 72.47 (a)
IRX1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRX1 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397976 35
tropical clawed frog
(Silurana tropicalis)
Amphibia irx1 35
  • 67.82 (n)
  • 68.97 (a)
Str.16884 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12613 35
irx1a 35
  • 67.37 (n)
  • 66.35 (a)
irx1a 36
  • 69 (a)
OneToMany
irx1b 36
  • 53 (a)
OneToMany
Species with no ortholog for IRX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX1 Gene

ENSEMBL:
Gene Tree for IRX1 (if available)
TreeFam:
Gene Tree for IRX1 (if available)

Paralogs for IRX1 Gene

Paralogs for IRX1 Gene

Selected SIMAP similar genes for IRX1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IRX1 Gene

genes like me logo Genes that share paralogs with IRX1: view

Variants for IRX1 Gene

Sequence variations from dbSNP and Humsavar for IRX1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs828335 -- 3,594,388(+) CAGGG(A/G)GTGAA upstream-variant-2KB
rs828336 -- 3,594,565(+) AGAGC(C/G)GCAGC upstream-variant-2KB
rs828337 -- 3,594,604(+) TAGGA(A/G)GTGGT upstream-variant-2KB
rs828338 -- 3,599,170(-) AGAGA(A/G)AGGGA intron-variant
rs828339 -- 3,599,135(-) CAAGA(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRX1 Gene

Variant ID Type Subtype PubMed ID
nsv461914 CNV Loss 19166990
dgv1747e1 CNV Complex 17122850
nsv428461 CNV Loss 18775914
dgv932n67 CNV Gain 20364138
nsv822983 CNV Gain 20364138
nsv822984 CNV Gain 20364138
nsv516530 CNV Loss 19592680
nsv10658 CNV Gain 18304495
esv22909 CNV Loss 19812545

Relevant External Links for IRX1 Gene

HapMap Linkage Disequilibrium report
IRX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX1 Gene

Disorders for IRX1 Gene

Relevant External Links for IRX1

Genetic Association Database (GAD)
IRX1
Human Genome Epidemiology (HuGE) Navigator
IRX1
genes like me logo Genes that share disorders with IRX1: view

No data available for UniProtKB/Swiss-Prot for IRX1 Gene

Publications for IRX1 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A genome-wide scan maps a novel high myopia locus to 5p15. (PMID: 18421076) Lam C.Y. … Lam D.S. (Invest. Ophthalmol. Vis. Sci. 2008) 3 48
  4. Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma. (PMID: 18559491) Bennett K.L. … Plass C. (Cancer Res. 2008) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for IRX1 Gene

Sources for IRX1 Gene

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