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Aliases for IRX1 Gene

Aliases for IRX1 Gene

  • Iroquois Homeobox 1 2 3 5
  • Iroquois Homeobox Protein 1 3 4
  • Homeodomain Protein IRXA1 3 4
  • IRXA1 3 4
  • IRX-5 3

External Ids for IRX1 Gene

Previous GeneCards Identifiers for IRX1 Gene

  • GC05P003743
  • GC05P003629
  • GC05P003648
  • GC05P003649

Summaries for IRX1 Gene

Entrez Gene Summary for IRX1 Gene

  • This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

GeneCards Summary for IRX1 Gene

IRX1 (Iroquois Homeobox 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX2.

Gene Wiki entry for IRX1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX1 Gene

Genomics for IRX1 Gene

Regulatory Elements for IRX1 Gene

Enhancers for IRX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRX1 Gene

3,596,054 bp from pter
3,601,403 bp from pter
5,350 bases
Plus strand

Genomic View for IRX1 Gene

Genes around IRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX1 Gene

Proteins for IRX1 Gene

  • Protein details for IRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iroquois-class homeodomain protein IRX-1
    Protein Accession:
    Secondary Accessions:
    • Q7Z2F8
    • Q8N312

    Protein attributes for IRX1 Gene

    480 amino acids
    Molecular mass:
    49621 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX1 Gene

Proteomics data for IRX1 Gene at MOPED

Post-translational modifications for IRX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX1 Gene

Domains & Families for IRX1 Gene

Gene Families for IRX1 Gene

Suggested Antigen Peptide Sequences for IRX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX1: view

Function for IRX1 Gene

genes like me logo Genes that share phenotypes with IRX1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IRX1 Gene

Localization for IRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX1 Gene

Subcellular locations from

Jensen Localization Image for IRX1 Gene COMPARTMENTS Subcellular localization image for IRX1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for IRX1 Gene

Pathways & Interactions for IRX1 Gene

SuperPathways for IRX1 Gene

No Data Available

Interacting Proteins for IRX1 Gene

Gene Ontology (GO) - Biological Process for IRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development IEA --
genes like me logo Genes that share ontologies with IRX1: view

No data available for Pathways by source and SIGNOR curated interactions for IRX1 Gene

Drugs & Compounds for IRX1 Gene

No Compound Related Data Available

Transcripts for IRX1 Gene

mRNA/cDNA for IRX1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRX1 Gene

Iroquois homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRX1 Gene

No ASD Table

Relevant External Links for IRX1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRX1 Gene

mRNA expression in normal human tissues for IRX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX1 Gene

This gene is overexpressed in Minor Salivary Gland (x9.6), Breast - Mammary Tissue (x8.1), Kidney - Cortex (x6.4), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for IRX1 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IRX1 Gene

SOURCE GeneReport for Unigene cluster for IRX1 Gene Hs.424156

genes like me logo Genes that share expression patterns with IRX1: view

Protein tissue co-expression partners for IRX1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for IRX1 Gene

Orthologs for IRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRX1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IRX1 35
  • 88.02 (n)
  • 91.97 (a)
IRX1 36
  • 93 (a)
(Canis familiaris)
Mammalia IRX1 35
  • 86.3 (n)
  • 89.66 (a)
IRX1 36
  • 89 (a)
(Mus musculus)
Mammalia Irx1 35
  • 85.9 (n)
  • 91.46 (a)
Irx1 16
Irx1 36
  • 91 (a)
(Pan troglodytes)
Mammalia IRX1 35
  • 99.57 (n)
  • 99.79 (a)
IRX1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Irx1 35
  • 85.97 (n)
  • 90.42 (a)
(Monodelphis domestica)
Mammalia IRX1 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia IRX1 36
  • 75 (a)
(Gallus gallus)
Aves IRX1 35
  • 71.61 (n)
  • 72.47 (a)
IRX1 36
  • 72 (a)
(Anolis carolinensis)
Reptilia IRX1 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia irx1 35
  • 67.82 (n)
  • 68.97 (a)
Str.16884 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397976 35
(Danio rerio)
Actinopterygii Dr.12613 35
irx1a 35
  • 67.37 (n)
  • 66.35 (a)
irx1a 36
  • 69 (a)
irx1b 36
  • 53 (a)
Species with no ortholog for IRX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX1 Gene

Gene Tree for IRX1 (if available)
Gene Tree for IRX1 (if available)

Paralogs for IRX1 Gene

Paralogs for IRX1 Gene

(3) SIMAP similar genes for IRX1 Gene using alignment to 1 proteins: Pseudogenes for IRX1 Gene

genes like me logo Genes that share paralogs with IRX1: view

Variants for IRX1 Gene

Sequence variations from dbSNP and Humsavar for IRX1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs828335 -- 3,594,388(+) CAGGG(A/G)GTGAA upstream-variant-2KB
rs828336 -- 3,594,565(+) AGAGC(C/G)GCAGC upstream-variant-2KB
rs828337 -- 3,594,604(+) TAGGA(A/G)GTGGT upstream-variant-2KB
rs828338 -- 3,599,170(-) AGAGA(A/G)AGGGA intron-variant
rs828339 -- 3,599,135(-) CAAGA(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRX1 Gene

Variant ID Type Subtype PubMed ID
nsv461914 CNV Loss 19166990
dgv1747e1 CNV Complex 17122850
nsv428461 CNV Loss 18775914
dgv932n67 CNV Gain 20364138
nsv822983 CNV Gain 20364138
nsv822984 CNV Gain 20364138
nsv516530 CNV Loss 19592680
nsv10658 CNV Gain 18304495
esv22909 CNV Loss 19812545

Variation tolerance for IRX1 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IRX1 Gene

Disorders for IRX1 Gene

Relevant External Links for IRX1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRX1 Gene

Publications for IRX1 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48 67
  2. IRX1 hypomethylation promotes osteosarcoma metastasis via induction of CXCL14/NF-I_B signaling. (PMID: 25822025) Lu J. … Wang J. (J. Clin. Invest. 2015) 3
  3. Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis. (PMID: 23456299) Park S.H. … Kim D.S. (Mol. Cells 2013) 3
  4. Genome-wide association study of antibody response to smallpox vaccine. (PMID: 22542470) Ovsyannikova I.G. … Poland G.A. (Vaccine 2012) 3
  5. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3

Products for IRX1 Gene

Sources for IRX1 Gene