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Aliases for IRS4 Gene

Aliases for IRS4 Gene

  • Insulin Receptor Substrate 4 2 3 5
  • 160 KDa Phosphotyrosine Protein 3 4
  • Phosphoprotein Of 160 KDa 3 4
  • PY160 3 4
  • IRS-4 3 4
  • Pp160 3 4

External Ids for IRS4 Gene

Previous GeneCards Identifiers for IRS4 Gene

  • GC0XM103383
  • GC0XM105051
  • GC0XM106008
  • GC0XM106747
  • GC0XM106171
  • GC0XM107781
  • GC0XM107862
  • GC0XM107975
  • GC0XM097599

Summaries for IRS4 Gene

Entrez Gene Summary for IRS4 Gene

  • IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRS4 Gene

IRS4 (Insulin Receptor Substrate 4) is a Protein Coding gene. Diseases associated with IRS4 include Exostosis and Lipodystrophy, Familial Partial, Type 2. Among its related pathways are Longevity regulating pathway and Regulation of lipolysis in adipocytes. GO annotations related to this gene include signal transducer activity and insulin receptor binding. An important paralog of this gene is IRS2.

UniProtKB/Swiss-Prot for IRS4 Gene

  • Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

Gene Wiki entry for IRS4 Gene

Additional gene information for IRS4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS4 Gene

Genomics for IRS4 Gene

Regulatory Elements for IRS4 Gene

Enhancers for IRS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH108736 0.9 ENCODE 0.7 -0.3 -255 1 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF391 EGR2 SP3 ZNF680 ELF4 USF2 IRS4 GC0XP108827
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRS4 on UCSC Golden Path with GeneCards custom track

Promoters for IRS4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247916 184 1201 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF391 EGR2 SP3 ZNF680 ELF4 ZEB2

Genomic Location for IRS4 Gene

Chromosome:
X
Start:
108,719,949 bp from pter
End:
108,736,584 bp from pter
Size:
16,636 bases
Orientation:
Minus strand

Genomic View for IRS4 Gene

Genes around IRS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS4 Gene

Proteins for IRS4 Gene

  • Protein details for IRS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14654-IRS4_HUMAN
    Recommended name:
    Insulin receptor substrate 4
    Protein Accession:
    O14654

    Protein attributes for IRS4 Gene

    Size:
    1257 amino acids
    Molecular mass:
    133768 Da
    Quaternary structure:
    • Interacts with SOCS6 in response to stimulation with either insulin or IGF1 (By similarity). Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH.

neXtProt entry for IRS4 Gene

Post-translational modifications for IRS4 Gene

  • Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction.
  • Ubiquitination at posLast=240240, isoforms=618, posLast=803803, isoforms=835, posLast=843843, and posLast=928928
  • Modification sites at PhosphoSitePlus

Other Protein References for IRS4 Gene

No data available for DME Specific Peptides for IRS4 Gene

Domains & Families for IRS4 Gene

Gene Families for IRS4 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IRS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IRS4: view

No data available for UniProtKB/Swiss-Prot for IRS4 Gene

Function for IRS4 Gene

Molecular function for IRS4 Gene

UniProtKB/Swiss-Prot Function:
Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
UniProtKB/Swiss-Prot Induction:
Down-regulated by PPP4C in a phosphatase activity-dependent manner.

Gene Ontology (GO) - Molecular Function for IRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IBA --
GO:0005070 SH3/SH2 adaptor activity TAS 9261155
GO:0005158 insulin receptor binding IBA --
GO:0005515 protein binding IPI 11316748
GO:0043548 phosphatidylinositol 3-kinase binding IBA --
genes like me logo Genes that share ontologies with IRS4: view
genes like me logo Genes that share phenotypes with IRS4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IRS4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRS4 Gene

Localization for IRS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRS4 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRS4 gene
Compartment Confidence
plasma membrane 4
cytosol 4
extracellular 2
endoplasmic reticulum 2
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane IBA,TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IRS4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IRS4 Gene

Pathways & Interactions for IRS4 Gene

genes like me logo Genes that share pathways with IRS4: view

SIGNOR curated interactions for IRS4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9261155
GO:0008286 insulin receptor signaling pathway IBA --
GO:0009967 positive regulation of signal transduction IEA --
GO:0019216 regulation of lipid metabolic process IBA --
genes like me logo Genes that share ontologies with IRS4: view

Drugs & Compounds for IRS4 Gene

(2) Drugs for IRS4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for IRS4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRS4: view

Transcripts for IRS4 Gene

mRNA/cDNA for IRS4 Gene

(4) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS4 Gene

Insulin receptor substrate 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for IRS4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for IRS4 Gene

No ASD Table

Relevant External Links for IRS4 Gene

GeneLoc Exon Structure for
IRS4
ECgene alternative splicing isoforms for
IRS4

Expression for IRS4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRS4 Gene

Protein differential expression in normal tissues from HIPED for IRS4 Gene

This gene is overexpressed in Pancreatic juice (51.6) and Heart (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IRS4 Gene



Protein tissue co-expression partners for IRS4 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRS4 Gene:

IRS4

SOURCE GeneReport for Unigene cluster for IRS4 Gene:

Hs.460872

mRNA Expression by UniProt/SwissProt for IRS4 Gene:

O14654-IRS4_HUMAN
Tissue specificity: Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma.

Evidence on tissue expression from TISSUES for IRS4 Gene

  • Kidney(4.4)
genes like me logo Genes that share expression patterns with IRS4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRS4 Gene

Orthologs for IRS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRS4 33
  • 99.01 (n)
cow
(Bos Taurus)
Mammalia IRS4 34
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRS4 34
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irs4 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRS4 34
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRS4 34
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRS4 34
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IRS4 (1 of 2) 34
  • 27 (a)
OneToMany
irs4a 34
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta chico 35 34
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToMany
Species where no ortholog for IRS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS4 Gene

ENSEMBL:
Gene Tree for IRS4 (if available)
TreeFam:
Gene Tree for IRS4 (if available)

Paralogs for IRS4 Gene

Paralogs for IRS4 Gene

genes like me logo Genes that share paralogs with IRS4: view

Variants for IRS4 Gene

Sequence variations from dbSNP and Humsavar for IRS4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_038042 A colorectal cancer sample
VAR_038043 A colorectal cancer sample
VAR_038044 A colorectal cancer sample
rs1000393283 -- 108,729,032(+) TAGAG(A/G)ACAAA intron-variant
rs1000470582 -- 108,729,629(+) AGTCA(C/T)GTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRS4 Gene

Variant ID Type Subtype PubMed ID
nsv519041 CNV gain 19592680

Variation tolerance for IRS4 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.18; 69.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRS4 Gene

Human Gene Mutation Database (HGMD)
IRS4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRS4 Gene

Disorders for IRS4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for IRS4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
exostosis
  • bone spur
lipodystrophy, familial partial, type 2
  • lipoatrophic diabetes
cribriform carcinoma
  • ductal carcinoma, cribriform type
boutonneuse fever
  • african tick typhus
- elite association - COSMIC cancer census association via MalaCards
Search IRS4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRS4

Genetic Association Database (GAD)
IRS4
Human Genome Epidemiology (HuGE) Navigator
IRS4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRS4
genes like me logo Genes that share disorders with IRS4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRS4 Gene

Publications for IRS4 Gene

  1. Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. (PMID: 9553137) Fantin VR … Lavan BE (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. (PMID: 9261155) Lavan BE … Lienhard GE (The Journal of biological chemistry 1997) 2 3 4 22 60
  3. Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation. (PMID: 17408801) Cuevas EP … Guijarro LG (Journal of hepatology 2007) 3 4 22 60
  4. Interaction between Brk kinase and insulin receptor substrate-4. (PMID: 15870689) Qiu H … Miller WT (Oncogene 2005) 3 4 22 60
  5. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation. (PMID: 15331607) Mihindukulasuriya KA … Tan TH (The Journal of biological chemistry 2004) 3 4 22 60

Products for IRS4 Gene

Sources for IRS4 Gene

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