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Aliases for IRS4 Gene

Aliases for IRS4 Gene

  • Insulin Receptor Substrate 4 2 3
  • 160 KDa Phosphotyrosine Protein 3 4
  • Phosphoprotein Of 160 KDa 3 4
  • PY160 3 4
  • IRS-4 3 4
  • Pp160 3 4

External Ids for IRS4 Gene

Previous GeneCards Identifiers for IRS4 Gene

  • GC0XM103383
  • GC0XM105051
  • GC0XM106008
  • GC0XM106747
  • GC0XM106171
  • GC0XM107781
  • GC0XM107862
  • GC0XM107975
  • GC0XM097599

Summaries for IRS4 Gene

Entrez Gene Summary for IRS4 Gene

  • IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRS4 Gene

IRS4 (Insulin Receptor Substrate 4) is a Protein Coding gene. Diseases associated with IRS4 include cribriform carcinoma and boutonneuse fever. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include phospholipid binding and SH3/SH2 adaptor activity. An important paralog of this gene is IRS2.

UniProtKB/Swiss-Prot for IRS4 Gene

  • Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

Gene Wiki entry for IRS4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS4 Gene

Genomics for IRS4 Gene

Regulatory Elements for IRS4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for IRS4 Gene

Start:
108,719,949 bp from pter
End:
108,736,413 bp from pter
Size:
16,465 bases
Orientation:
Minus strand

Genomic View for IRS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS4 Gene

Proteins for IRS4 Gene

  • Protein details for IRS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14654-IRS4_HUMAN
    Recommended name:
    Insulin receptor substrate 4
    Protein Accession:
    O14654
    Secondary Accessions:

    Protein attributes for IRS4 Gene

    Size:
    1257 amino acids
    Molecular mass:
    133768 Da
    Quaternary structure:
    • Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1 (By similarity). Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH.

neXtProt entry for IRS4 Gene

Proteomics data for IRS4 Gene at MOPED

Post-translational modifications for IRS4 Gene

  • Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction.
  • Ubiquitination at Lys240, Lys618, Lys803, Lys835, Lys843, and Lys928
  • Modification sites at PhosphoSitePlus

Other Protein References for IRS4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IRS4 Gene

Domains for IRS4 Gene

Suggested Antigen Peptide Sequences for IRS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14654

UniProtKB/Swiss-Prot:

IRS4_HUMAN :
  • O14654
Domain:
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with IRS4: view

No data available for Gene Families for IRS4 Gene

Function for IRS4 Gene

Molecular function for IRS4 Gene

UniProtKB/Swiss-Prot Function: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.
UniProtKB/Swiss-Prot Induction: Down-regulated by PPP4C in a phosphatase activity-dependent manner.

Gene Ontology (GO) - Molecular Function for IRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005070 SH3/SH2 adaptor activity TAS 9261155
GO:0005158 insulin receptor binding IBA --
GO:0005515 protein binding IPI 11316748
GO:0043548 phosphatidylinositol 3-kinase binding IBA --
genes like me logo Genes that share ontologies with IRS4: view
genes like me logo Genes that share phenotypes with IRS4: view

Animal Models for IRS4 Gene

MGI Knock Outs for IRS4:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRS4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IRS4 Gene

Localization for IRS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRS4 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRS4 Gene COMPARTMENTS Subcellular localization image for IRS4 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for IRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane TAS --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with IRS4: view

Pathways for IRS4 Gene

genes like me logo Genes that share pathways with IRS4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Insulin Signaling Pathway in human,mouse,rat
    • Polycomb & Trithorax Target Genes in human,mouse,rat

Gene Ontology (GO) - Biological Process for IRS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9261155
GO:0008286 insulin receptor signaling pathway IBA --
GO:0009967 positive regulation of signal transduction TAS 9261155
GO:0019216 regulation of lipid metabolic process IBA --
genes like me logo Genes that share ontologies with IRS4: view

Compounds for IRS4 Gene

(4) Novoseek inferred chemical compound relationships for IRS4 Gene

Compound -log(P) Hits PubMed IDs
phosphotyrosine 62.4 4
tyrosine 54.2 8
phosphatidylinositol 53.7 2
glucose 8.8 2
genes like me logo Genes that share compounds with IRS4: view

Transcripts for IRS4 Gene

mRNA/cDNA for IRS4 Gene

(1) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS4 Gene

Insulin receptor substrate 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRS4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for IRS4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRS4 Gene

No ASD Table

Relevant External Links for IRS4 Gene

GeneLoc Exon Structure for
IRS4
ECgene alternative splicing isoforms for
IRS4

Expression for IRS4 Gene

mRNA expression in normal human tissues for IRS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRS4 Gene

SOURCE GeneReport for Unigene cluster for IRS4 Gene Hs.460872

mRNA Expression by UniProt/SwissProt for IRS4 Gene

O14654-IRS4_HUMAN
Tissue specificity: Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma.
genes like me logo Genes that share expressions with IRS4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for IRS4 Gene

Orthologs for IRS4 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRS4 35
  • 99.01 (n)
  • 98.39 (a)
cow
(Bos Taurus)
Mammalia IRS4 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRS4 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irs4 16
Irs4 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRS4 36
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRS4 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRS4 36
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IRS4 (1 of 2) 36
  • 27 (a)
OneToMany
irs4a 36
  • 25 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta chico 36
  • 18 (a)
OneToMany
chico 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for IRS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS4 Gene

ENSEMBL:
Gene Tree for IRS4 (if available)
TreeFam:
Gene Tree for IRS4 (if available)

Paralogs for IRS4 Gene

Paralogs for IRS4 Gene

genes like me logo Genes that share paralogs with IRS4: view

Variants for IRS4 Gene

Sequence variations from dbSNP and Humsavar for IRS4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1801164 - 108,733,710(-) CAGAT(C/G/T)ATGAG reference, missense
rs1801165 -- 108,733,697(-) CCCAA(A/C)GAATA reference, missense
rs5929142 -- 108,726,211(+) TTATA(C/G)CTTTG intron-variant
rs6622345 -- 108,729,929(+) CAGTA(C/G)CAACA intron-variant
rs11403667 -- 108,729,288(+) TTTTT(-/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRS4 Gene

Variant ID Type Subtype PubMed ID
nsv519041 CNV Gain 19592680

Relevant External Links for IRS4 Gene

HapMap Linkage Disequilibrium report
IRS4
Human Gene Mutation Database (HGMD)
IRS4
Locus Specific Mutation Databases (LSDB)
IRS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRS4 Gene

Disorders for IRS4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for IRS4 Gene including...

Search for IRS4 Gene in MalaCards »

(2) University of Copenhagen DISEASES for IRS4 Gene

(2) Novoseek inferred disease relationships for IRS4 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 0 1
tumors 0 4

Relevant External Links for IRS4

Genetic Association Database (GAD)
IRS4
Human Genome Epidemiology (HuGE) Navigator
IRS4
genes like me logo Genes that share disorders with IRS4: view

No data available for UniProtKB/Swiss-Prot for IRS4 Gene

Publications for IRS4 Gene

  1. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. (PMID: 9261155) Lavan B.E. … Lienhard G.E. (J. Biol. Chem. 1997) 2 3 4 23
  2. Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. (PMID: 9553137) Fantin V.R. … Lavan B.E. (J. Biol. Chem. 1998) 2 3 4 23
  3. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PMID: 9614078) Koval A.P. … LeRoith D. (J. Biol. Chem. 1998) 3 4 23
  4. The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II. (PMID: 11316748) Karas M. … LeRoith D. (Endocrinology 2001) 3 4 23
  5. Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor. (PMID: 12639902) Schreyer S. … Eckel J. (Endocrinology 2003) 3 4 23

Products for IRS4 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Insulin Signaling Pathway in human,mouse,rat
    • Polycomb & Trithorax Target Genes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate IRS4
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for IRS4
    • Block miRNA regulation of IRS4 using miScript Target Protectors

    Sources for IRS4 Gene

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