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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRS4 Gene

protein-coding   GIFtS: 64
GCID: GC0XM107975

Insulin Receptor Substrate 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Insulin Receptor Substrate 41 2     pp1602 3
Phosphoprotein Of 160 KDa2 3     PY1602
160 KDa Phosphotyrosine Protein2 3     py1603
IRS-42 3     

External Ids:    HGNC: 61281   Entrez Gene: 84712   Ensembl: ENSG000001331247   OMIM: 3009045   UniProtKB: O146543   

Export aliases for IRS4 gene to outside databases

Previous GC identifers: GC0XM103383 GC0XM105051 GC0XM106008 GC0XM106747 GC0XM106171 GC0XM107781 GC0XM107862 GC0XM097599


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRS4 Gene:
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and
serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with
cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin
receptor tyrosine kinase upon receptor stimulation.. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRS4 Gene: 
IRS4 (insulin receptor substrate 4) is a protein-coding gene. Diseases associated with IRS4 include cribriform carcinoma, and boutonneuse fever, and among its related super-pathways are Translation Insulin regulation of translation and IRS-related events. GO annotations related to this gene include SH3/SH2 adaptor activity and phospholipid binding. An important paralog of this gene is IRS1.

UniProtKB/Swiss-Prot: IRS4_HUMAN, O14654
Function: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such
as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2
domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD
phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis.
Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in
nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of
hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in
response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth,
reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing
the function of IRS1 and IRS2

Gene Wiki entry for IRS4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRS4 gene promoter:
         HOXA3   Sp1   Lmo2   MIF-1   Tal-1beta   YY1   POU2F1   POU2F1a   ARP-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRS4 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRS4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3   Ensembl cytogenetic band:  Xq22.3   HGNC cytogenetic band: Xq22.3

IRS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRS4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM107975:  view genomic region     (about GC identifiers)

Start:
107,975,712 bp from pter      End:
107,979,651 bp from pter
Size:
3,940 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRS4_HUMAN, O14654 (See protein sequence)
Recommended Name: Insulin receptor substrate 4  
Size: 1257 amino acids; 133768 Da
Subunit: Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1 (By similarity). Interacts
with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated
YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Explore the universe of human proteins at neXtProt for IRS4: NX_O14654

Explore proteomics data for IRS4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in
    response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and
    phosphatidylinositol 3-kinase interaction
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14654

  • IRS4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRS4 Protein Expression
    REFSEQ proteins: NP_003595.1  
    ENSEMBL proteins: 
     ENSP00000361202  
    Reactome Protein details: O14654
    Human Recombinant Protein Products for IRS4: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for IRS4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for IRS4
    GenScript Custom Purified and Recombinant Proteins Services for IRS4
    Novus Biologicals IRS4 Protein
    Novus Biologicals IRS4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRS4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--

    IRS4 for ontologies           About GeneDecksing



    IRS4 Antibody Products: 
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    Novus Biologicals IRS4 Antibodies
    Abcam antibodies for IRS4
    Cloud-Clone Corp. Antibodies for IRS4 
    ThermoFisher Antibodies for IRS4
    LSBio Antibodies in human, mouse, rat for IRS4 

    Assay Products for IRS4: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRS4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRS4 
    Cloud-Clone Corp. CLIAs for IRS4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O14654

    ProtoNet protein and cluster: O14654

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB002404 Insulin receptor substrate-1 PTB domain signature


    UniProtKB/Swiss-Prot: IRS4_HUMAN, O14654
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    IRS4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRS4_HUMAN, O14654
    Function: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such
    as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2
    domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD
    phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis.
    Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in
    nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of
    hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in
    response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth,
    reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing
    the function of IRS1 and IRS2
    Induction: Down-regulated by PPP4C in a phosphatase activity-dependent manner

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005070SH3/SH2 adaptor activity TAS9261155
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI11316748
    GO:0005543phospholipid binding IEA--
         
    IRS4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irs4):
     behavior/neurological  growth/size  homeostasis/metabolism  reproductive system 

    IRS4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irs4tm1Lhd for IRS4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRS4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRS4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRS4 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRS4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate IRS4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IRS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRS4

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of IRS4

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for IRS4 (see all 7)
    OriGene ORF clones in mouse, rat for IRS4
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    GenScript: all cDNA clones in your preferred vector: IRS4 (NM_003604)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRS4
    Sirion Biotech Customized lentivirus for stable overexpression of IRS4 
                         Customized lentivirus expression plasmids for stable overexpression of IRS4 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IRS4
    Search LifeMap BioReagents cell lines for IRS4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRS4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IRS4 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Translation Insulin regulation of translation
    Transcription Receptor-mediated HIF regulation0.51
    Insulin signaling pathway0.31
    2IRS-related events
    IRS-related events triggered by IGF1R0.93
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    IGF1R signaling cascade0.92
    3Signaling by GPCR
    Signal Transduction0.55
    4Rho Family GTPases
    ILK Signaling0.49
    5TGF-Beta Pathway
    SOCS Pathway0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for IRS4
        Transcription Receptor-mediated HIF regulation

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRS4
        IGF1R Signaling
    ILK Signaling
    SOCS Pathway

    1 GeneGo (Thomson Reuters) Pathway for IRS4
        Transcription Receptor-mediated HIF regulation

    2 BioSystems Pathways for IRS4
        Insulin Signaling
    Adipogenesis

    4        Reactome Pathways for IRS4
        Signal Transduction
    IGF1R signaling cascade
    IRS-related events triggered by IGF1R
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)


    3         Kegg Pathways  (Kegg details for IRS4):
        Insulin signaling pathway
    Adipocytokine signaling pathway
    Type II diabetes mellitus


    IRS4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/215 Interacting proteins for IRS4 (O146542, 3 ENSP000003612024) via UniProtKB, MINT, STRING, and/or I2D (see all 215)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461082, 3, ENSP000003005744MINT-8029160 MINT-8027919 MINT-8033822 MINT-8034333 MINT-8033807 MINT-8027934 MINT-8034348 MINT-8029175 I2D: score=3 STRING: ENSP00000300574
    ERBB2P046262, 3, ENSP000002695714MINT-74556 I2D: score=1 STRING: ENSP00000269571
    MAP3K1Q132332, 3MINT-48301 I2D: score=2 
    TNFRSF1BP203332, 3MINT-49404 I2D: score=2 
    EGFRP005332, 3, ENSP000002754934MINT-74554 MINT-74555 I2D: score=1 STRING: ENSP00000275493
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9261155

    IRS4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRS4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRS4

    4 Novoseek inferred chemical compound relationships for IRS4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 62.4 4 9261155 (2), 9553137 (1), 10403832 (1)
    tyrosine 54.2 10 9261155 (2), 12639902 (2), 9553137 (1), 15870689 (1) (see all 6)
    phosphatidylinositol 53.7 2 9553137 (1), 10077007 (1)
    glucose 8.8 4 11932207 (1), 14604813 (1)

    Search CenterWatch for drugs/clinical trials and news about IRS4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRS4 gene: 
    NM_003604.2  

    Unigene Cluster for IRS4:

    Insulin receptor substrate 4
    Hs.460872  [show with all ESTs]
    Unigene Representative Sequence: AF007567
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372129(uc004eoc.2)
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for IRS4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRS4
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    OriGene clones in human, mouse for IRS4 (see all 7)
    OriGene ORF clones in mouse, rat for IRS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRS4 (NM_003604)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRS4
    Sirion Biotech Customized lentivirus for stable overexpression of IRS4 
                         Customized lentivirus expression plasmids for stable overexpression of IRS4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for IRS4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRS4
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRS4

    Additional mRNA sequence: AF007567.1 

    1 DOTS entry:

    DT.404599 

    2 AceView cDNA sequences:

    AF007567 NM_003604 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRS4 expression in normal human tissues (normalized intensities)      IRS4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCACTA
    IRS4 Expression
    About this image


    IRS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 14 entries
             Thalamus
             Substantia Nigra   
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 2 entries
             Epiblast Cells Epiblast
             Epiblast Stem Cell line 5
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neural Tube (Nervous System)
             brain/midbrain/lateral wall   

    See IRS4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRS4

    SOURCE GeneReport for Unigene cluster: Hs.460872

    UniProtKB/Swiss-Prot: IRS4_HUMAN, O14654
    Tissue specificity: Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma

        SABiosciences Expression via Pathway-Focused PCR Arrays including IRS4: 
              Insulin Signaling Pathway in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for IRS4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irs41 , 5 insulin receptor substrate 41, 5 83.68(n)1
    80.13(a)1
      X (62.43 cM)5
    163701  NM_010572.21  NP_034702.21 
     1417109985 
    chicken
    (Gallus gallus)
    Aves IRS46
    insulin receptor substrate 4
    25(a)
    1 ↔ 1
    4(13836789-13855653)
    lizard
    (Anolis carolinensis)
    Reptilia IRS46
    Uncharacterized protein
    29(a)
    1 ↔ 1
    GL343202.1(4296021-4298968)
    zebrafish
    (Danio rerio)
    Actinopterygii IRS4 (1 of 2)6
    irs4a6
    insulin receptor substrate 4a
    23(a)
    20(a)
    many → 1
    many → 1
    7(52700940-52704181)
    21(41921451-41932976)
    fruit fly
    (Drosophila melanogaster)
    Insecta chico3 insulin receptor signaling pathway
    insulin-like more
    32(a)   31B1   --


    ENSEMBL Gene Tree for IRS4 (if available)
    TreeFam Gene Tree for IRS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRS4 gene
    IRS12  IRS22  

    IRS4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 SNPs in IRS4 are shown (see all 163)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0380444
    A colorectal cancer sample4--see VAR_0380442 G R mis40--------
    VAR_0380434
    A colorectal cancer sample4--see VAR_0380432 G E mis40--------
    VAR_0380424
    A colorectal cancer sample4--see VAR_0380422 A V mis40--------
    rs1378538941,2
    C,Funtested1107947553(-) CGCCGG/AGTGCC 2 /R syn11Minor allele frequency- A:0.00NA 4454
    rs18011641,2,4
    C,F,Huntested1107948581(-) CAGATC/G/TATGAG 2 H Y mis114MN NA EA NS WA CSA 5069
    rs1378538961,2
    C,Funtested1107949901(-) CACCCA/TGCCCA 2 S C mis11Minor allele frequency- T:0.00NA 4524
    rs1842503721,2
    --107946909(+) CTTTCC/TTGGTA 1 -- ds50010--------
    rs1899498291,2
    --107947175(+) ATCCTC/TATGCT 1 -- ds50010--------
    rs285750401,2
    C,F--107947241(+) AATCAC/GTTCTG 1 -- ds50011Minor allele frequency- G:0.00CSA 1
    rs178472281,2
    C--107947344(-) GTGCTA/GTTCGA 1 -- ds50012Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for IRS4 (107975712 - 107979651 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for IRS4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519041CNV Gain19592680


    Human Gene Mutation Database (HGMD): IRS4

    Locus Specific Mutation Databases (LSDB): IRS4
    5/8 SABiosciences Cancer Mutation PCR Assays for IRS4 (see all 8):
    Cosmic IdAA Change
    32917p.A20V
    78972p.E70*
    75034p.P971L
    32205p.G557R
    71197p.R731H
    SeqTarget long-range PCR primers for resequencing IRS4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300904    OMIM disorders: --

    13 diseases for IRS4:    About MalaCards
    cribriform carcinoma    boutonneuse fever    exostosis    spotted fever
    hepatoblastoma    metabolic disorders    diabetes mellitus    insulin resistance
    schizophrenia    pancreatic cancer    hepatocellular carcinoma    pancreatitis
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for IRS4:
    Boutonneuse fever     Cribriform carcinoma

    IRS4 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for IRS4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 1 15870689 (1)
    tumors 0 4 19795387 (3), 15331607 (1)

    Genetic Association Database (GAD): IRS4
    Human Genome Epidemiology (HuGE) Navigator: IRS4 (8 documents)

    Export disorders for IRS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRS4 gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with IRS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells. (PubMed id 9553137)1, 2, 3, 9 Fantin V.R....Lavan B.E. (1998)
    2. A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. (PubMed id 9261155)1, 2, 3, 9 Lavan B.E....Lienhard G.E. (1997)
    3. Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor. (PubMed id 12639902)1, 2, 9 Schreyer S.... Eckel J. (2003)
    4. Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation. (PubMed id 17408801)1, 2, 9 Cuevas E.P.... Guijarro L.G. (2007)
    5. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation. (PubMed id 15331607)1, 2, 9 Mihindukulasuriya K.A.... Tan T.-H. (2004)
    6. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis. (PubMed id 10594015)1, 2, 9 Uchida T.... White M.F. (2000)
    7. Interaction between Brk kinase and insulin receptor substrate-4. (PubMed id 15870689)1, 2, 9 Qiu H.... Miller W.T. (2005)
    8. The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II. (PubMed id 11316748)1, 2, 9 Karas M.... LeRoith D. (2001)
    9. Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4. (PubMed id 15316024)1, 2, 9 Hinsby A.M.... Mann M. (2004)
    10. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin- like growth factor-I receptor-mediated signal transduction. (PubMed id 9614078)1, 2, 9 Koval A.P.... LeRoith D. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8471 HGNC: 6128 AceView: IRS4 Ensembl:ENSG00000133124 euGenes: HUgn8471
    ECgene: IRS4 Kegg: 8471 H-InvDB: IRS4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRS4 gene:
    Search GeneIP for patents involving IRS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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