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Aliases for IRS2 Gene

Aliases for IRS2 Gene

  • Insulin Receptor Substrate 2 2 3
  • IRS-2 3 4

External Ids for IRS2 Gene

Summaries for IRS2 Gene

Entrez Gene Summary for IRS2 Gene

  • This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRS2 Gene

IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include diabetes mellitus, noninsulin-dependent and insulin-like growth factor i. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include phospholipid binding and signal transducer activity. An important paralog of this gene is IRS4.

UniProtKB/Swiss-Prot for IRS2 Gene

  • May mediate the control of various cellular processes by insulin

Gene Wiki entry for IRS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS2 Gene

Genomics for IRS2 Gene

Genomic Location for IRS2 Gene

Start:
109,752,698 bp from pter
End:
109,786,568 bp from pter
Size:
33,871 bases
Orientation:
Minus strand

Genomic View for IRS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS2 Gene

Regulatory Elements for IRS2 Gene

Proteins for IRS2 Gene

  • Protein details for IRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4H2-IRS2_HUMAN
    Recommended name:
    Insulin receptor substrate 2
    Protein Accession:
    Q9Y4H2
    Secondary Accessions:
    • Q96RR2
    • Q9BZG0
    • Q9Y6I5

    Protein attributes for IRS2 Gene

    Size:
    1338 amino acids
    Molecular mass:
    137334 Da
    Quaternary structure:
    • Interacts with PHIP.

    Three dimensional structures from OCA and Proteopedia for IRS2 Gene

neXtProt entry for IRS2 Gene

Proteomics data for IRS2 Gene at MOPED

Post-translational modifications for IRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IRS2 Gene

Domains for IRS2 Gene

Gene Families for IRS2 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

UniProtKB/Swiss-Prot:

IRS2_HUMAN
Domain:
  • Contains 1 IRS-type PTB domain.:
    • Q9Y4H2
  • Contains 1 PH domain.:
    • Q9Y4H2
genes like me logo Genes that share domains with IRS2: view

Function for IRS2 Gene

Molecular function for IRS2 Gene

GENATLAS Biochemistry: insulin receptor substrate 2,pleiotropes mediator of insulin coordinating Igf-1 receptor-mediated beta cell development and peripheral insertion signaling,interacting with several proteins containing SH2 domains,such as PIKRs,GRB2,unlikely to be involved in NIDDM
UniProtKB/Swiss-Prot Function: May mediate the control of various cellular processes by insulin

Gene Ontology (GO) - Molecular Function for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005158 insulin receptor binding IBA --
GO:0005515 protein binding IPI 17901049
GO:0019901 protein kinase binding IEA --
GO:0019903 protein phosphatase binding IEA --
genes like me logo Genes that share ontologies with IRS2: view
genes like me logo Genes that share phenotypes with IRS2: view

Animal Models for IRS2 Gene

MGI Knock Outs for IRS2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IRS2 Gene

Localization for IRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRS2 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRS2 Gene COMPARTMENTS Subcellular localization image for IRS2 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 3
endoplasmic reticulum 2
extracellular 2

Gene Ontology (GO) - Cellular Components for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with IRS2: view

Pathways for IRS2 Gene

SuperPathways for IRS2 Gene

Superpath Contained pathways
1 IL-9 Signaling Pathways
2 PI-3K cascade
3 Signaling by FGFR
4 Insulin receptor signalling cascade
5 Translation Insulin regulation of translation
genes like me logo Genes that share pathways with IRS2: view

Gene Ontology (GO) - Biological Process for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002903 negative regulation of B cell apoptotic process ISS --
GO:0006006 glucose metabolic process TAS 9495343
GO:0007165 signal transduction TAS 7675087
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IRS2: view

Compounds for IRS2 Gene

(39) Novoseek inferred chemical compound relationships for IRS2 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 80.9 69
tyrosine 71.2 119
glucose 67.8 78
phosphotyrosine 65.2 9
glycogen 63.6 12
genes like me logo Genes that share compounds with IRS2: view

Transcripts for IRS2 Gene

mRNA/cDNA for IRS2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(216) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS2 Gene

Insulin receptor substrate 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRS2 Gene

No ASD Table

Relevant External Links for IRS2 Gene

GeneLoc Exon Structure for
IRS2
ECgene alternative splicing isoforms for
IRS2

Expression for IRS2 Gene

mRNA expression in normal human tissues for IRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRS2 Gene

SOURCE GeneReport for Unigene cluster for IRS2 Gene Hs.442344

genes like me logo Genes that share expressions with IRS2: view

Orthologs for IRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRS2 36
  • 97.69 (n)
  • 96.93 (a)
IRS2 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRS2 36
  • 84.79 (n)
  • 85.02 (a)
IRS2 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRS2 36
  • 87.38 (n)
  • 88.79 (a)
IRS2 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irs2 36
  • 80.8 (n)
  • 84.75 (a)
Irs2 16
Irs2 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRS2 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irs2 36
  • 81.48 (n)
  • 85.69 (a)
chicken
(Gallus gallus)
Aves IRS2 36
  • 74.39 (n)
  • 73.72 (a)
IRS2 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.694 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498409 36
  • 57.07 (n)
  • 59.42 (a)
zebrafish
(Danio rerio)
Actinopterygii irs2 36
  • 61.73 (n)
  • 60.74 (a)
IRS2 37
  • 53 (a)
OneToOne
zgc56306 36
fruit fly
(Drosophila melanogaster)
Insecta chico 37
  • 19 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.5303 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 36 (a)
OneToMany
Species with no ortholog for IRS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS2 Gene

ENSEMBL:
Gene Tree for IRS2 (if available)
TreeFam:
Gene Tree for IRS2 (if available)

Paralogs for IRS2 Gene

Paralogs for IRS2 Gene

Selected SIMAP similar genes for IRS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IRS2: view

Variants for IRS2 Gene

Sequence variations from dbSNP and Humsavar for IRS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs754204 -- 109,759,221(+) TAAAG(C/T)GAGAA intron-variant
rs754205 -- 109,759,295(+) CACAG(A/C)CCTGC intron-variant
rs874016 -- 109,764,046(-) GGCTA(C/T)GTGGT intron-variant
rs913949 -- 109,759,449(+) AGGCT(A/G)GAGCA intron-variant
rs928190 -- 109,758,862(+) GGAAA(A/G)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRS2 Gene

Variant ID Type Subtype PubMed ID
dgv348n67 CNV Gain 20364138
nsv526943 CNV Loss 19592680
nsv826791 CNV Loss 20364138
nsv9108 CNV Gain+Loss 18304495
esv2500078 CNV Deletion 19546169
esv2747995 CNV Deletion 23290073
nsv512337 CNV Loss 21212237
esv29023 CNV Gain+Loss 19812545
nsv821265 CNV Deletion 20802225
esv2747997 CNV Deletion 23290073
esv2157648 CNV Deletion 18987734
esv2660355 CNV Deletion 23128226
nsv818995 CNV Gain 17921354
dgv349n67 CNV Gain 20364138
nsv826796 CNV Gain 20364138
esv22887 CNV Loss 19812545
esv2658062 CNV Deletion 23128226

Relevant External Links for IRS2 Gene

HapMap Linkage Disequilibrium report
IRS2
Human Gene Mutation Database (HGMD)
IRS2

Disorders for IRS2 Gene

(1) OMIM Diseases for IRS2 Gene (600797)

(3) University of Copenhagen DISEASES for IRS2 Gene

(28) Novoseek inferred disease relationships for IRS2 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 77.1 50
insulin sensitivity 61 8
obesity 52.2 13
hyperinsulinemia 47.9 6
niddm 40.7 7

Relevant External Links for IRS2

Genetic Association Database (GAD)
IRS2
Human Genome Epidemiology (HuGE) Navigator
IRS2
genes like me logo Genes that share disorders with IRS2: view

No data available for UniProtKB/Swiss-Prot for IRS2 Gene

Publications for IRS2 Gene

  1. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (PMID: 12687350) Lautier C. … Grigorescu F. (Hum. Genet. 2003) 3 4 23 49
  2. Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. (PMID: 12475767) Le Fur S. … BougnA"res P. (Diabetes 2002) 3 23 49
  3. Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes. (PMID: 12519871) D'Alfonso R. … Sesti G. (J. Clin. Endocrinol. Metab. 2003) 3 23 49
  4. [Detection of single-nucleotide polymorphisms in insulin receptor substrate-2 gene 3'-untranslated region by denaturing high-performance liquid chromatography]. (PMID: 14653106) Zeng W.M. … Xie P. (Hunan Yi Ke Da Xue Xue Bao 2003) 3 23 49
  5. Variations in insulin secretion in carriers of gene variants in IRS-1 and -2. (PMID: 11872698) 't Hart L.M. … van Haeften T.W. (Diabetes 2002) 3 23 49

Products for IRS2 Gene

Sources for IRS2 Gene

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