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Aliases for IRS2 Gene

Aliases for IRS2 Gene

  • Insulin Receptor Substrate 2 2 3 5
  • IRS-2 3 4

External Ids for IRS2 Gene

Previous GeneCards Identifiers for IRS2 Gene

  • GC13M108766
  • GC13M104793
  • GC13M109242
  • GC13M108132
  • GC13M108104
  • GC13M109204
  • GC13M110406
  • GC13M091005

Summaries for IRS2 Gene

Entrez Gene Summary for IRS2 Gene

  • This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRS2 Gene

IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include Diabetes Mellitus, Noninsulin-Dependent and Fatty Liver Disease. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is IRS1.

UniProtKB/Swiss-Prot for IRS2 Gene

  • May mediate the control of various cellular processes by insulin.

Gene Wiki entry for IRS2 Gene

Additional gene information for IRS2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS2 Gene

Genomics for IRS2 Gene

Regulatory Elements for IRS2 Gene

Enhancers for IRS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H109776 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +4.2 4153 11.6 PKNOX1 SIN3A FEZF1 YY1 ZNF766 GLIS2 KLF7 FOS ZNF202 SP3 RN7SKP10 MYO16-AS2 RPL21P107 IRS2 ENSG00000275741 GC13M109755
GH13H109653 1.2 FANTOM5 Ensembl ENCODE 18.2 +131.9 131868 3.4 SUZ12 ZSCAN4 CEBPB MAX MNT CEBPG RCOR1 MYC IRS2 PIR55972 LOC101927627
GH13H109704 1.6 FANTOM5 Ensembl ENCODE 13.5 +80.6 80570 3.8 FOXA2 PKNOX1 ATF1 ARNT BRCA1 YY1 ZNF766 CBX5 GATA2 ATF7 LINC00676 IRS2 PIR55972 LOC101927627
GH13H109153 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +628.5 628464 9.3 HDGF TBL1XR1 RB1 SIN3A BMI1 RAD21 BATF RFX5 SMARCC2 ZNF207 IRS2 MYO16-AS1 MYO16 LOC105370356
GH13H110023 1 Ensembl ENCODE dbSUPER 19.4 -237.5 -237542 1.2 PKNOX1 POLR2A EBF1 IRS2 ENSG00000276269 ENSG00000274331
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRS2 on UCSC Golden Path with GeneCards custom track

Promoters for IRS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000065719 268 3800 PKNOX1 SIN3A ZNF766 GLIS2 KLF7 ZNF202 SP3 REST SMARCB1 MBD2

Genomic Locations for IRS2 Gene

Genomic Locations for IRS2 Gene
33,871 bases
Minus strand

Genomic View for IRS2 Gene

Genes around IRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS2 Gene

Proteins for IRS2 Gene

  • Protein details for IRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin receptor substrate 2
    Protein Accession:
    Secondary Accessions:
    • Q96RR2
    • Q9BZG0
    • Q9Y6I5

    Protein attributes for IRS2 Gene

    1338 amino acids
    Molecular mass:
    137334 Da
    Quaternary structure:
    • Interacts with PHIP.

    Three dimensional structures from OCA and Proteopedia for IRS2 Gene

neXtProt entry for IRS2 Gene

Post-translational modifications for IRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRS2 Gene

Domains & Families for IRS2 Gene

Gene Families for IRS2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IRS2: view

No data available for UniProtKB/Swiss-Prot for IRS2 Gene

Function for IRS2 Gene

Molecular function for IRS2 Gene

GENATLAS Biochemistry:
insulin receptor substrate 2,pleiotropes mediator of insulin coordinating Igf-1 receptor-mediated beta cell development and peripheral insertion signaling,interacting with several proteins containing SH2 domains,such as PIKRs,GRB2,unlikely to be involved in NIDDM
UniProtKB/Swiss-Prot Function:
May mediate the control of various cellular processes by insulin.

Phenotypes From GWAS Catalog for IRS2 Gene

Gene Ontology (GO) - Molecular Function for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity TAS,IBA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005158 insulin receptor binding IBA --
GO:0005515 protein binding IPI 8662806
GO:0016303 1-phosphatidylinositol-3-kinase activity TAS --
genes like me logo Genes that share ontologies with IRS2: view
genes like me logo Genes that share phenotypes with IRS2: view

Animal Models for IRS2 Gene

MGI Knock Outs for IRS2:

Clone Products

  • Addgene plasmids for IRS2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRS2 Gene

Localization for IRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRS2 Gene

Cytoplasm, cytosol.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRS2 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
endoplasmic reticulum 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Aggresome (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IBA --
GO:0005886 plasma membrane TAS,IEA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with IRS2: view

Pathways & Interactions for IRS2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Common Cytokine Receptor Gamma-Chain Family Signaling Pathways
3 Regulation of lipid metabolism Insulin signaling-generic cascades
4 PI3K/AKT activation
5 Type I Interferon Signaling Pathways
genes like me logo Genes that share pathways with IRS2: view

SIGNOR curated interactions for IRS2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002903 negative regulation of B cell apoptotic process IEA,ISS --
GO:0006006 glucose metabolic process TAS 9495343
GO:0007165 signal transduction TAS 7675087
genes like me logo Genes that share ontologies with IRS2: view

Drugs & Compounds for IRS2 Gene

(25) Drugs for IRS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(14) Additional Compounds for IRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRS2: view

Transcripts for IRS2 Gene

mRNA/cDNA for IRS2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(216) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS2 Gene

Insulin receptor substrate 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for IRS2

Alternative Splicing Database (ASD) splice patterns (SP) for IRS2 Gene

No ASD Table

Relevant External Links for IRS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IRS2 Gene

This gene is overexpressed in Brain (27.8) and Cerebrospinal fluid (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IRS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IRS2 Gene:


SOURCE GeneReport for Unigene cluster for IRS2 Gene:


Evidence on tissue expression from TISSUES for IRS2 Gene

  • Liver(4.7)
  • Blood(4.5)
  • Nervous system(3.5)
  • Muscle(3.1)
  • Pancreas(3)
  • Heart(2.3)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with IRS2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRS2 Gene

Orthologs for IRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRS2 33 34
  • 97.69 (n)
(Canis familiaris)
Mammalia IRS2 33 34
  • 87.38 (n)
(Bos Taurus)
Mammalia IRS2 33 34
  • 84.79 (n)
(Rattus norvegicus)
Mammalia Irs2 33
  • 81.48 (n)
(Mus musculus)
Mammalia Irs2 33 16 34
  • 80.8 (n)
(Monodelphis domestica)
Mammalia IRS2 34
  • 73 (a)
(Gallus gallus)
Aves IRS2 33 34
  • 74.39 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498409 33
  • 57.07 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.694 33
(Danio rerio)
Actinopterygii irs2 33
  • 61.73 (n)
IRS2 34
  • 53 (a)
zgc56306 33
fruit fly
(Drosophila melanogaster)
Insecta chico 34
  • 19 (a)
(Oryza sativa)
Liliopsida Os.5303 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
Species where no ortholog for IRS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS2 Gene

Gene Tree for IRS2 (if available)
Gene Tree for IRS2 (if available)

Paralogs for IRS2 Gene

Paralogs for IRS2 Gene

(2) SIMAP similar genes for IRS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IRS2: view

Variants for IRS2 Gene

Sequence variations from dbSNP and Humsavar for IRS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs137852740 other 109,784,115(-) GCAAC(C/G/T)TGGGG reference, synonymous-codon, missense
rs1805097 other 109,782,884(-) CCCGG(A/G)CGCCG reference, missense
rs1000090189 -- 109,773,878(+) ATCAA(C/G)ATACA intron-variant
rs1000280917 -- 109,759,379(+) CGCGG(C/T)GATTT intron-variant
rs1000417619 -- 109,787,793(+) CGGGC(A/G)GGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IRS2 Gene

Variant ID Type Subtype PubMed ID
nsv951919 CNV deletion 24416366
nsv9108 CNV gain+loss 18304495
nsv826796 CNV gain 20364138
nsv826791 CNV loss 20364138
nsv821265 CNV deletion 20802225
nsv818995 CNV gain 17921354
nsv563094 CNV loss 21841781
nsv563088 CNV loss 21841781
nsv563076 CNV loss 21841781
nsv563072 CNV loss 21841781
nsv526943 CNV loss 19592680
nsv512337 CNV loss 21212237
nsv1136175 CNV deletion 24896259
nsv1131065 CNV deletion 24896259
nsv1126353 CNV deletion 24896259
nsv1071125 CNV deletion 25765185
nsv1044855 CNV gain 25217958
esv3582827 CNV gain 25503493
esv3403446 CNV duplication 20981092
esv29023 CNV gain+loss 19812545
esv2747997 CNV deletion 23290073
esv2747995 CNV deletion 23290073
esv2660355 CNV deletion 23128226
esv2658062 CNV deletion 23128226
esv2500078 CNV deletion 19546169
esv22887 CNV loss 19812545
esv2157648 CNV deletion 18987734
dgv349n67 CNV gain 20364138
dgv348n67 CNV gain 20364138
dgv3389n54 CNV gain+loss 21841781
dgv3388n54 CNV gain 21841781
dgv3387n54 CNV gain 21841781
dgv3386n54 CNV gain+loss 21841781
dgv3385n54 CNV loss 21841781

Variation tolerance for IRS2 Gene

Gene Damage Index Score: 6.02; 75.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRS2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRS2 Gene

Disorders for IRS2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IRS2 Gene - From: HGMD, OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
fatty liver disease
  • alcoholic fatty liver
gestational diabetes
  • gdm
  • obesity, association with
insulin-like growth factor i
  • insulin-like growth factor 1 resistance to
- elite association - COSMIC cancer census association via MalaCards
Search IRS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRS2 Gene

Publications for IRS2 Gene

  1. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (PMID: 12687350) Lautier C … Grigorescu F (Human genetics 2003) 3 4 22 45 60
  2. The IRS2 Gly1057Asp variant is associated with human longevity. (PMID: 19887537) Barbieri M … Paolisso G (The journals of gerontology. Series A, Biological sciences and medical sciences 2010) 3 22 45 60
  3. Insulin receptor substrate-2 gene polymorphism: is it associated with endometrial cancer? (PMID: 20184486) Cayan F … Dilek S (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2010) 3 22 45 60
  4. The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population. (PMID: 19332049) Ouederni TB … Benammar-Elgaaied A (Clinical biochemistry 2009) 3 22 45 60
  5. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. (PMID: 19818665) Attaoua R … Grigorescu F (Diabetes & metabolism 2009) 3 22 45 60

Products for IRS2 Gene

  • Addgene plasmids for IRS2

Sources for IRS2 Gene

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