External Ids for IRS2 Gene
Previous GeneCards Identifiers for IRS2 Gene
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRS2 Gene
IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include diabetes mellitus, noninsulin-dependent and insulin-like growth factor i. Among its related pathways are PI-3K cascade and PI-3K cascade. GO annotations related to this gene include phospholipid binding and signal transducer activity. An important paralog of this gene is IRS4.
UniProtKB/Swiss-Prot for IRS2 Gene
May mediate the control of various cellular processes by insulin