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IRS2 Gene

protein-coding   GIFtS: 66
GCID: GC13M110406

Insulin Receptor Substrate 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Insulin Receptor Substrate 21 2
IRS-22 3

External Ids:    HGNC: 61261   Entrez Gene: 86602   Ensembl: ENSG000001859507   OMIM: 6007975   UniProtKB: Q9Y4H23   

Export aliases for IRS2 gene to outside databases

Previous GC identifers: GC13M108766 GC13M104793 GC13M109242 GC13M108132 GC13M108104 GC13M109204 GC13M091005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRS2 Gene:
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of
insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse
receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin
receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in
response to IL4 treatment. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRS2 Gene:
IRS2 (insulin receptor substrate 2) is a protein-coding gene. Diseases associated with IRS2 include carbohydrate metabolic disorder, and diabetes mellitus, noninsulin-dependent. GO annotations related to this gene include phospholipid binding and signal transducer activity. An important paralog of this gene is IRS1.

UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2
Function: May mediate the control of various cellular processes by insulin

Gene Wiki entry for IRS2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRS2 gene promoter:
         E2F   AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRS2 promoter sequence
   Search Chromatin IP Primers for IRS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

IRS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M110406:  view genomic region     (about GC identifiers)

Start:
110,406,184 bp from pter      End:
110,438,915 bp from pter
Size:
32,732 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2 (See protein sequence)
Recommended Name: Insulin receptor substrate 2  
Size: 1338 amino acids; 137334 Da
Subunit: Interacts with PHIP (By similarity)
2 PDB 3D structures from and Proteopedia for IRS2:
3FQW (3D)        3FQX (3D)    
Secondary accessions: Q96RR2 Q9BZG0 Q9Y6I5

Explore the universe of human proteins at neXtProt for IRS2: NX_Q9Y4H2

Explore proteomics data for IRS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003740.2  
    ENSEMBL proteins: 
     ENSP00000365016  
    Reactome Protein details: Q9Y4H2

    IRS2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for IRS2
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    Novus Biologicals IRS2 Protein
    Novus Biologicals IRS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRS2

    IRS2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRS2
    R&D Systems Antibodies for IRS2
    Cell Signaling Technology (CST) Antibodies for IRS2 
    OriGene Antibodies for IRS2
    OriGene Custom Antibody Services for IRS2
    Novus Biologicals IRS2 Antibodies
    Abcam antibodies for IRS2
    Cloud-Clone Corp. Antibodies for IRS2
    ThermoFisher Antibody for IRS2
    LSBio Antibodies in human, mouse, rat for IRS2

    IRS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for IRS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRS2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for IRS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRS2
    Cloud-Clone Corp. CLIAs for IRS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    3 InterPro protein domains:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4H2

    ProtoNet protein and cluster: Q9Y4H2

    2 Blocks protein domains:
    IPB001849 Pleckstrin-like
    IPB002404 Insulin receptor substrate-1 PTB domain signature


    UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    IRS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRS2_HUMAN, Q9Y4H2
    Function: May mediate the control of various cellular processes by insulin

         Genatlas biochemistry entry for IRS2:
    insulin receptor substrate 2,pleiotropes mediator of insulin coordinating Igf-1 receptor-mediated beta cell
    development and peripheral insertion signaling,interacting with several proteins containing SH2 domains,such as
    PIKRs,GRB2,unlikely to be involved in NIDDM

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI17901049
    GO:0019901protein kinase binding IEA--
    GO:0019903protein phosphatase binding IEA--
         
    IRS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IRS2:
     Increased peripheral focal adh  Upregulation of Wnt/beta-caten 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Irs2) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size/body  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  normal  pigmentation  renal/urinary system 

    IRS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for IRS2: Irs2tm1Mfw Irs2tm1.1With Irs2tm1Tka

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRS2:
    hsa-let-7e-5p (MIRT051561), hsa-mir-98-5p (MIRT027863), hsa-mir-145-5p (MIRT006332), hsa-mir-7-5p (MIRT003808), hsa-mir-374b-5p (MIRT016052), hsa-let-7b-5p (MIRT052219), hsa-mir-33a-5p (MIRT007355), hsa-mir-484 (MIRT041990)

    Block miRNA regulation of human, mouse, rat IRS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRS2 (see all 101):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-3916 hsa-miR-30a hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidIRS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRS2
    Predesigned siRNA for gene silencing in human, mouse, rat IRS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRS2

    Clone
    Products:
         
    OriGene clones in human, mouse for IRS2 (see all 7)
    OriGene ORF clones in mouse, rat for IRS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRS2 (NM_003749)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRS2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for IRS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for IRS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRS2_HUMAN, Q9Y4H2: Cytoplasm, cytosol (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus3
    endoplasmic reticulum2
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--

    IRS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRS2 About   (see all 42)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1IL-9 Signaling Pathways
    IL-9 Signaling Pathways0.90
    IL-9 Signaling Pathway0.42
    IL-7 Signaling Pathways0.90
    Immune response IL 9 signaling pathway0.42
    IL-21 Signaling Pathways0.90
    IL-7 Signaling Pathway0.40
    Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    Development Thrombopoietin regulated cell processes0.38
    2Translation Insulin regulation of translation
    Translation Insulin regulation of translation0.59
    Translation Regulation activity of EIF20.47
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Development Growth hormone signaling via PI3K AKT and MAPK cascades0.34
    Transcription Receptor mediated HIF regulation0.51
    Insulin signaling pathway0.32
    3Development IGF 1 receptor signaling
    Development IGF 1 receptor signaling0.48
    Immune response IL 4 signaling pathway0.39
    4Development EPO induced Jak STAT pathway
    EPO Receptor Signaling0.42
    EPO signaling pathway0.34
    5Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected R&D Systems Pathways for IRS2 (see all 8)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IRS2 (see all 10)
        IL-9 Pathway
    IGF1R Signaling
    IL-4 Pathway
    GDNF-Family Ligands and Receptor Interactions
    Interferon Pathway

    1 Cell Signaling Technology (CST) Pathway for IRS2
        Glucose / Energy Metabolism

    Selected GeneGo (Thomson Reuters) Pathways for IRS2 (see all 12)
        Development Thrombopoietin-regulated cell processes
    Translation Regulation of EIF2 activity
    Immune response IL-9 signaling pathway
    Development IGF-1 receptor signaling
    Immune response IL-10 signaling pathway

    Selected BioSystems Pathways for IRS2 (see all 15)
        Adipogenesis
    Insulin Signaling
    EPO Receptor Signaling
    BDNF signaling pathway
    Interferon type I

    Selected Reactome Pathways for IRS2 (see all 10)
        PI3K Cascade
    PI3K/AKT activation
    Signal attenuation
    SOS-mediated signalling
    Constitutive PI3K/AKT Signaling in Cancer

    1 PharmGKB Pathway for IRS2
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for IRS2) (see all 6):
        FoxO signaling pathway
    Insulin signaling pathway
    Adipocytokine signaling pathway
    Type II diabetes mellitus
    Non-alcoholic fatty liver disease (NAFLD)


    IRS2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRS2: 
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRS2 (Q9Y4H21, 2, 3 ENSP000003650164) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INSRP062132, 3, ENSP000003038304MINT-17941 MINT-17940 MINT-18199 MINT-18198 I2D: score=3 STRING: ENSP00000303830
    YWHAEP622582, 3, ENSP000002643354MINT-8005157 I2D: score=3 STRING: ENSP00000264335
    SFNP319472, 3MINT-3975441 I2D: score=2 
    PIK3R1P279861, 2, 3, ENSP000002743354EBI-1049582,EBI-79464 MINT-8427689 I2D: score=5 STRING: ENSP00000274335
    IGF1RP080692, 3, ENSP000002680354MINT-17857 MINT-18053 I2D: score=3 STRING: ENSP00000268035
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002903negative regulation of B cell apoptotic process ISS--
    GO:0006006glucose metabolic process TAS9495343
    GO:0007165signal transduction TAS7675087
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    IRS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRS2

    Selected Novoseek inferred chemical compound relationships for IRS2 gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 80.9 105 14596677 (5), 9651339 (3), 9766646 (2), 9421369 (2) (see all 52)
    tyrosine 71.2 166 20092705 (6), 15840293 (5), 17901049 (4), 9334184 (4) (see all 77)
    glucose 67.8 112 15537654 (5), 16151975 (4), 16271533 (4), 16037106 (4) (see all 51)
    phosphotyrosine 65.2 12 10525667 (2), 15297443 (2), 10497255 (1), 9195949 (1) (see all 7)
    glycogen 63.6 17 11471071 (1), 11459778 (1), 11481324 (1), 9892238 (1) (see all 12)
    ly294002 57.9 7 11359902 (2), 12594228 (1), 11228049 (1), 9832424 (1) (see all 5)
    wortmannin 51.5 2 9832424 (1), 19494713 (1)
    lactacystin 42.4 4 15537654 (2)
    pd 98,059 41.5 1 11228049 (1)
    serine 35.9 5 11779863 (1), 16899578 (1), 20219981 (1), 10781824 (1) (see all 5)



    IRS2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IRS2 gene: 
    NM_003749.2  

    Unigene Cluster for IRS2:

    Insulin receptor substrate 2
    Hs.442344  [show with all ESTs]
    Unigene Representative Sequence: NM_003749
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375856(uc001vqv.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat IRS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRS2 (see all 101):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-3916 hsa-miR-30a hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmidIRS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IRS2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRS2 (NM_003749)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRS2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRS2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IRS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRS2
      QuantiTect SYBR Green Assays in human, mouse, rat IRS2
      QuantiFast Probe-based Assays in human, mouse, rat IRS2

    Additional mRNA sequence: 

    AF073310.1 AF161416.1 BC012414.1 BC026044.1 BC042858.1 BC063516.1 BC066356.1 BC110638.1 

    2 DOTS entries:

    DT.317740  DT.100783228 

    Selected AceView cDNA sequences (see all 216):

    BU782701 AI148082 BF740269 CB053432 N42921 AI867402 AA129863 AI359041 
    AI168652 AW134817 BE858642 BU782547 CB132629 AI066632 AA707485 AA553757 
    BM692576 BU740264 BM983398 BM710040 CD723366 BC012414 BE042396 BC026044 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    IRS2 expression in normal human tissues (normalized intensities)      IRS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCCCTCC
    IRS2 Expression
    About this image


    IRS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
    IRS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442344
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRS2: 
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for IRS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRS2
    QuantiTect SYBR Green Assays in human, mouse, rat IRS2
    QuantiFast Probe-based Assays in human, mouse, rat IRS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IRS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irs21 , 5 insulin receptor substrate 21, 5 80.8(n)1
    84.75(a)1
      8 (5.35 cM)5
    3847831  NM_001081212.11  NP_001074681.11 
     109869615 
    chicken
    (Gallus gallus)
    Aves IRS21 insulin receptor substrate 2 74.39(n)
    73.72(a)
      428017  XM_425588.4  XP_425588.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    many ↔ many
    GL344707.1(6588-21092)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6942 Xenopus laevis insulin receptor substrate protein mRNA, more 79.23(n)    AF297960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563062 hypothetical protein MGC56306 73.71(n)   393285  BC050518.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chico6
    chico
    19(a)
    1 → many
    2L(10242512-10247078)
    rice
    (Oryza sativa)
    Liliopsida Os.53032 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.12(n)    AK121510.1 


    ENSEMBL Gene Tree for IRS2 (if available)
    TreeFam Gene Tree for IRS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRS2 gene
    IRS12  IRS42  
    2 SIMAP similar genes for IRS2 using alignment to 6 protein entries:     IRS2_HUMAN (see all proteins):
    irs-2    IRS1

    IRS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRS2 (see all 742)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18050971,2,,4
    C,F,Aother1110435231(-) CCCGGA/GCGCCG 2 D G mis1 ese32Minor allele frequency- G:0.38MN NA 304
    rs1378527401,2
    Cother1110436462(-) GCAACC/G/TTGGGG 2 L V mis11NA 4068
    rs1429332391,2
    --110405688(+) CGTTGA/GTGTAT 1 -- ds50010--------
    rs64922251,2
    C,F,H--110405966(+) GAGTAA/CATCGA 1 -- ds500126Minor allele frequency- C:0.16NA NS EA WA CSA 2492
    rs1474198321,2
    --110405979(+) GTTCTC/GTTTTG 1 -- ds50010--------
    rs1846640511,2
    --110406150(+) AAACAA/GAGAAT 1 -- ds50010--------
    rs1891241651,2
    --110406265(+) ATACAA/GTGCAC 1 -- ut310--------
    rs1815029061,2
    --110406636(+) GATAGA/TGGAAA 1 -- ut310--------
    rs1847756401,2
    --110406795(+) CCTATC/TGTACC 1 -- ut310--------
    rs1482996481,2
    --110406812(+) GAGTTA/GCAAAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IRS2 (110406184 - 110438915 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IRS2 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660355CNV Deletion23128226
    esv2500078CNV Deletion19546169
    esv2658062CNV Deletion23128226
    esv2747995CNV Deletion23290073
    esv2157648CNV Deletion18987734
    esv2747997CNV Deletion23290073
    nsv821265CNV Deletion20802225
    nsv526943CNV Loss19592680
    nsv826791CNV Loss20364138
    esv22887CNV Loss19812545

    Human Gene Mutation Database (HGMD): IRS2
    3 Site Specific Mutation Identification with PCR Assays for IRS2:
    Cosmic IdAA Change
    32318p.P1036_A1037insP
    26911p.A940T
    27210p.G607D
    SeqTarget long-range PCR primers for resequencing IRS2
    DNA2.0 Custom Variant and Variant Library Synthesis for IRS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600797   
    OMIM disorders: 125853  
    Selected diseases for IRS2 (see all 59):    About MalaCards
    carbohydrate metabolic disorder    diabetes mellitus, noninsulin-dependent    glucose intolerance    polycystic ovary syndrome
    insulin resistance    hyperinsulinism    malignant peripheral nerve sheath tumor    hyperglycemia
    werner syndrome    hyperandrogenism    neurofibroma    leiomyosarcoma
    fatty liver disease    atopy    pancreatic cancer    retinitis pigmentosa
    hypercholesterolemia    osteoporosis    obesity    liver disease

    3 diseases from the University of Copenhagen DISEASES database for IRS2:
    Diabetes mellitus     Hyperglycemia     Hyperinsulinism

    IRS2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for IRS2 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 77.1 67 15840293 (4), 20092705 (4), 18834442 (3), 12687350 (3) (see all 34)
    insulin sensitivity 61 10 15811564 (3), 12475767 (2), 10525667 (1), 15048126 (1) (see all 5)
    obesity 52.2 16 12687350 (4), 16652127 (2), 20184486 (1), 16086274 (1) (see all 9)
    hyperinsulinemia 47.9 7 17127239 (2), 11259670 (1), 17416760 (1), 14504291 (1) (see all 5)
    niddm 40.7 9 14682250 (2), 14653106 (2), 9758433 (1), 12189449 (1) (see all 5)
    polycystic ovary syndrome 40.3 8 11522686 (2), 15840293 (2), 16037106 (2), 10973656 (1)
    bone loss age-related 37.7 2 15576984 (1), 15651373 (1)
    polycystic ovaries 32.1 2 10973656 (2)
    breast cancer 30.9 40 19261680 (5), 14534541 (4), 16707456 (3), 18819936 (3) (see all 14)
    diabetes gestational 25.3 2 10973656 (2)

    Genetic Association Database (GAD): IRS2
    Human Genome Epidemiology (HuGE) Navigator: IRS2 (55 documents)

    Export disorders for IRS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRS2 gene, integrated from 10 sources (see all 460):
    (articles sorted by number of sources associating them with IRS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (PubMed id 12687350)1, 2, 4, 9 Lautier C.... Grigorescu F. (Hum. Genet. 2003)
    2. 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. (PubMed id 9312143)1, 2, 3, 9 Ogihara T.... Asano T. (J. Biol. Chem. 1997)
    3. Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene. (PubMed id 10077005)1, 2, 9 Vassen L.... Klein-Hitpass L. (Mol. Endocrinol. 1999)
    4. The G1057D polymorphism of IRS-2 gene is not associated with type 2 diabetes and obese patients among ethnic groups in Tunisian population. (PubMed id 19332049)1, 4, 9 Ouederni T.B....Benammar-Elgaaied A. (Clin. Biochem. 2009)
    5. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. (PubMed id 19818665)1, 4, 9 Attaoua R....Grigorescu F. (amp 2009)
    6. The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer. (PubMed id 15308584)1, 4, 9 Wagner K....FAPrsti A. (Carcinogenesis 2004)
    7. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. (PubMed id 11030756)1, 4, 9 Mammarella S....Cama A. (Hum. Mol. Genet. 2000)
    8. Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes. (PubMed id 12519871)1, 4, 9 D'Alfonso R....Sesti G. (J. Clin. Endocrinol. Metab. 2003)
    9. Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. (PubMed id 12475767)1, 4, 9 Le Fur S....BougnA"res P. (Diabetes 2002)
    10. The IRS2 Gly1057Asp variant is associated with human longevity. (PubMed id 19887537)1, 4, 9 Barbieri M....Paolisso G. (J. Gerontol. A Biol. Sci. Med. Sci. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8660 HGNC: 6126 AceView: IRS2 Ensembl:ENSG00000185950 euGenes: HUgn8660
    ECgene: IRS2 Kegg: 8660 H-InvDB: IRS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IRS2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IRS2 gene:
    Search GeneIP for patents involving IRS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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