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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRS2 Gene

protein-coding   GIFtS: 66
GCID: GC13M110406

insulin receptor substrate 2
 Explore 58 diseases affiliated with
IRS2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRS2    

Aliases
for IRS2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Insulin Receptor Substrate 21 2
IRS-22 3

External Ids:    HGNC: 61261   Entrez Gene: 86602   Ensembl: ENSG000001859507   OMIM: 6007975   UniProtKB: Q9Y4H23   

Export aliases for IRS2 gene to outside databases

Previous GC identifers: GC13M108766 GC13M104793 GC13M109242 GC13M108132 GC13M108104 GC13M109204 GC13M091005


Summaries
for IRS2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRS2:
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin,
insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine
kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase
upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2
Function: May mediate the control of various cellular processes by insulin

Gene Wiki entry for IRS2


Genomic Views
for IRS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRS2 gene promoter:
         E2F   AP-1   ATF-2   NRSF form 1   c-Jun   NRSF form 2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: IRS2 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

IRS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRS2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M110406:  view genomic region     (about GC identifiers)

Start:
 110,406,184 bp from pter      End:
 110,438,915 bp from pter
Size:
 32,732 bases      Orientation:
 minus strand

Proteins
for IRS2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2 (See protein sequence)
Recommended Name: Insulin receptor substrate 2  
Size: 1338 amino acids; 137334 Da
Subunit: Interacts with PHIP (By similarity)
Subcellular location: Cytoplasm, cytosol (By similarity)
2 PDB 3D structures from and Proteopedia for IRS2:
3FQW (3D)        3FQX (3D)    
Secondary accessions: Q96RR2 Q9BZG0 Q9Y6I5

Explore the universe of human proteins at neXtProt for IRS2: NX_Q9Y4H2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y4H2

    • IRS2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003740.2  
    ENSEMBL proteins: 
     ENSP00000365016  
    Reactome Protein details: Q9Y4H2
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: IRS2
    OriGene Custom Protein Services for IRS2 
    GenScript Custom Purified and Recombinant Proteins Services for IRS2
    Novus Biologicals IRS2 Protein
    Novus Biologicals IRS2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRS2

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005792microsome ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--


    IRS2 for ontologies           About GeneDecksing



    IRS2 Antibody Products: 
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    R&D Systems Antibodies for IRS2
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    Abcam antibodies for IRS2 
    Uscn Antibodies for IRS2
    ThermoFisher Antibody for IRS2

    Assay Products for IRS2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for IRS2

    Protein Domains /
    Families
    for IRS2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRS2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002404 Insln_rcpt_S1
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y4H2

    ProtoNet protein and cluster: Q9Y4H2

    2 Blocks protein families:
    IPB001849 Pleckstrin-like
    IPB002404 Insulin receptor substrate-1 PTB domain signature


    UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2
    Similarity: Contains 1 IRS-type PTB domain
    Similarity: Contains 1 PH domain


    Function
    for IRS2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRS2_HUMAN, Q9Y4H2
    Function: May mediate the control of various cellular processes by insulin

         Genatlas biochemistry entry for IRS2:
    insulin receptor substrate 2,pleiotropes mediator of insulin coordinating Igf-1 receptor-mediated beta cell development
    and peripheral insertion signaling,interacting with several proteins containing SH2 domains,such as
    PIKRs,GRB2,unlikely to be involved in NIDDM

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat IRS2
    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate IRS2 (see all 101):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-3916 hsa-miR-30a hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmid: IRS2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRS2 (see all 4)
    OriGene shRNA RFP: IRS2
    OriGene siRNA: IRS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRS2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRS2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRS2 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRS2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: IRS2 (NM_003749)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRS2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRS2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for IRS2
    Search LifeMap BioReagents cell lines for IRS2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRS2

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IEA--
    GO:0005158insulin receptor binding IEA--
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IEA--
    GO:0019901protein kinase binding IEA--


    IRS2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IRS2:
     Increased peripheral focal adh  Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-outs for IRS2: Irs2tm1Mfw Irs2tm1.1With Irs2tm1Tka
         15/16 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Irs2) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland 
     growth/size  homeostasis/metabolism  immune system  integument  mortality/aging 
     muscle  nervous system  normal  pigmentation  renal/urinary system 

    IRS2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRS2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/40 super-pathways (see all 40) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1IL-9 Signaling Pathways
    8/15 pathways (see all 15)
    		IL-9 Signaling Pathways1.00
    		Immune response_IL-9 signaling pathway0.42
    		IL-21 Signaling Pathways0.90
    		Immune response IL-9 signaling pathway0.42
    		IL-7 Signaling Pathways0.90
    		IL-7 Signaling Pathway0.38
    		Common Cytokine Receptor Gamma-Chain Family Signaling Pathways0.90
    		Development_Thrombopoietin-regulated cell processes0.36
    2Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    3Development_CNTF receptor signaling
    8/11 pathways (see all 11)
    		Transcription Receptor-mediated HIF regulation0.43
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Transcription_Receptor-mediated HIF regulation0.43
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Regulation of lipid metabolism_Insulin signaling-generic cascades0.35
    		Translation _Regulation of EIF2 activity0.25
    		Translation_Insulin regulation of translation0.35
    		Translation Regulation activity of EIF20.25
    4PIP3 activates AKT signaling
    8/10 pathways (see all 10)
    		PI-3K cascade1.00
    		PI3K/AKT activation0.97
    		PIP3 activates AKT signaling1.00
    		GAB1 signalosome0.96
    		PI3K/AKT Signaling in Cancer1.00
    		Constitutive PI3K/AKT Signaling in Cancer0.88
    		PI3K events in ERBB2 signaling1.00
    		Signaling by SCF-KIT0.72
    5IRS-related events
    		IRS-related events1.00
    		Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.90
    		IRS-mediated signalling0.98
    		IGF1R signaling cascade0.90
    		Insulin receptor signalling cascade0.94
    		PI3K Cascade0.84
    		IRS-related events triggered by IGF1R0.93
    		Signaling by Insulin receptor0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/11 EMD Millipore Pathways for IRS2 (see all 11)
        Translation Insulin regulation of translation
    Immune response IL-9 signaling pathway
    Immune response IL-4 signaling pathway
    Development Leptin signaling via PI3K-dependent pathway
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades

    5/8 R&D Systems Pathways for IRS2 (see all 8)
        IL-21 Signaling Pathways
    IL-2 Signaling Pathways
    IL-4 Signaling Pathways
    Adipocytokines & Insulin Signaling
    IL-7 Signaling Pathways

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for IRS2 (see all 10)
        IL-9 Pathway
    IGF1R Signaling
    IL-4 Pathway
    GDNF-Family Ligands and Receptor Interactions
    Interferon Pathway

    1 Cell Signaling Technology (CST) Pathway for IRS2
        Glucose / Energy Metabolism

    5/12 GeneGo (Thomson Reuters) Pathways for IRS2 (see all 12)
        Development Thrombopoietin-regulated cell processes
    Translation Regulation of EIF2 activity
    Immune response IL-9 signaling pathway
    Development IGF-1 receptor signaling
    Immune response IL-10 signaling pathway

    5/14 BioSystems Pathways for IRS2 (see all 14) 
        EPO Receptor Signaling
    Adipogenesis
    Alpha6-Beta4 Integrin Signaling Pathway
    IL-7 Signaling Pathway
    Insulin Signaling

    5/42        Reactome Pathways for IRS2 (see all 42)
        Signaling by EGFR in Cancer
    Downstream signal transduction
    IRS-mediated signalling
    Signal Transduction
    Signaling by PDGF

    1 PharmGKB Pathway for IRS2
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

    5         Kegg Pathways  (Kegg details for IRS2):
        Neurotrophin signaling pathway
    Insulin signaling pathway
    Adipocytokine signaling pathway
    Type II diabetes mellitus
    Aldosterone-regulated sodium reabsorption


    IRS2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/93 Interacting proteins for IRS2 (Q9Y4H21, 2, 3 ENSP000003650164) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622582, 3, ENSP000002643354MINT-8005157 I2D: score=3 STRING: ENSP00000264335
    SFNP319472, 3MINT-3975441 I2D: score=2 
    INSRP062132, 3, ENSP000003038304MINT-17941 MINT-17940 MINT-18199 MINT-18198 I2D: score=3 STRING: ENSP00000303830
    IGF1RP080692, 3, ENSP000002680354MINT-17857 MINT-18053 I2D: score=3 STRING: ENSP00000268035
    YWHAZP631042, 3, ENSP000003095034MINT-3295882 I2D: score=3 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002053positive regulation of mesenchymal cell proliferation IEA--
    GO:0002903negative regulation of B cell apoptotic process ISS--
    GO:0006006glucose metabolic process TAS9495343
    GO:0007165signal transduction TAS7675087
    GO:0007420brain development IEA--


    IRS2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRS2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRS2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRS2
    10/39 Novoseek chemical compound relationships for IRS2 gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 80.9 105 14596677 (5), 9651339 (3), 9766646 (2), 9421369 (2) (see all 52)
    tyrosine 71.2 166 20092705 (6), 15840293 (5), 17901049 (4), 9334184 (4) (see all 77)
    glucose 67.8 112 15537654 (5), 16151975 (4), 16271533 (4), 16037106 (4) (see all 51)
    phosphotyrosine 65.2 12 10525667 (2), 15297443 (2), 10497255 (1), 9195949 (1) (see all 7)
    glycogen 63.6 17 11471071 (1), 11459778 (1), 11481324 (1), 9892238 (1) (see all 12)
    ly294002 57.9 7 11359902 (2), 12594228 (1), 11228049 (1), 9832424 (1) (see all 5)
    wortmannin 51.5 2 9832424 (1), 19494713 (1)
    lactacystin 42.4 4 15537654 (2)
    pd 98,059 41.5 1 11228049 (1)
    serine 35.9 5 11779863 (1), 16899578 (1), 20219981 (1), 10781824 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about IRS2 

    Transcripts
    for IRS2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRS2 gene: 
    NM_003749.2  

    Unigene Cluster for IRS2:

    Insulin receptor substrate 2
    Hs.442344  [show with all ESTs]
    Unigene Representative Sequence: NM_003749
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000375856(uc001vqv.3)

    miRNA
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    8/101 QIAGEN miScript miRNA Assays for microRNAs that regulate IRS2 (see all 101):
    hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-3916 hsa-miR-30a hsa-miR-208b
    SwitchGear 3'UTR luciferase reporter plasmid: IRS2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRS2 (see all 4)
    OriGene shRNA RFP: IRS2
    OriGene siRNA: IRS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRS2
    Clone
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    GenScript: all cDNA clones in your preferred vector: IRS2 (NM_003749)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat IRS2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRS2

    Additional cDNA sequence: 

    AF073310.1 AF161416.1 BC012414.1 BC026044.1 BC042858.1 BC063516.1 BC066356.1 BC110638.1 

    2 DOTS entries:

    DT.317740  DT.100783228 

    24/216 AceView cDNA sequences (see all 216):

    BF590749 AI359041 AI168652 BF726126 AI867402 BF594231 BM663798 BX281779 
    CB132629 BM692576 CA952668 AW009103 CD723366 BG618719 AI066632 N42921 
    BM710040 CB136256 AW236355 AA505676 N50191 NM_003749 BU740264 BQ270575 

    GeneLoc Exon Structure


    Expression
    for IRS2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGCCCTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    IRS2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See IRS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRS2

    SOURCE GeneReport for Unigene cluster: Hs.442344
        SABiosciences Expression via Pathway-Focused PCR Arrays including IRS2: 
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              Diabetes in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRS2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRS2

    Orthologs
    for IRS2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for IRS2 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IRS21 insulin receptor substrate 2 73.9(n)
    73.46(a)    		   428017  XM_425588.3  XP_425588.3 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.6942 Xenopus laevis insulin receptor substrate protein mRNA, more 79.23(n)    AF297960.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc563062 hypothetical protein MGC56306 73.71(n)   393285  BC050518.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta chico6
    		 chico
    		 19(a)
    		 1 → many
    		 2L(10242512-10247078)
    rice
    (Oryza sativa)    		 Liliopsida Os.53032 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.12(n)    AK121510.1 


    ENSEMBL Gene Tree for IRS2 (if available)
    TreeFam Gene Tree for IRS2 (if available) 

    Paralogs
    for IRS2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRS2 gene
    IRS12  IRS42  
    2 SIMAP similar genes for IRS2 using alignment to 6 protein entries:     IRS2_HUMAN (see all proteins):
    irs-2    IRS1

    IRS2 for paralogs           About GeneDecksing



    Genomic Variants
    for IRS2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/623 NCBI SNPs in IRS2 are shown (see all 623)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1378527401,2
    		Cother110436462(-) GCAACC/G/TTGGGG 3 L V mis1 syn11NA 4068
    rs1429332391,2
    		--110405688(+) CGTTGA/GTGTAT 1 -- ds50010--------
    rs64922251,2
    		C,F,H,--110405966(+) GAGTAA/CATCGA 1 -- ds500126Minor allele frequency- C:0.16NA NS EA WA CSA 2492
    rs1474198321,2
    		--110405979(+) GTTCTC/GTTTTG 1 -- ds50010--------
    rs1846640511,2
    		--110406150(+) AAACAA/GAGAAT 1 -- ds50010--------
    rs1891241651,2
    		--110406265(+) ATACAA/GTGCAC 1 -- ut310--------
    rs1815029061,2
    		--110406636(+) GATAGA/TGGAAA 1 -- ut310--------
    rs1847756401,2
    		--110406795(+) CCTATC/TGTACC 1 -- ut310--------
    rs1482996481,2
    		--110406812(+) GAGTTA/GCAAAG 1 -- ut310--------
    rs1147644001,2
    		C,--110406817(+) ACAAAC/GCAAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for IRS2 (110406184 - 110438915 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for IRS2
         7 CNVs: 71782 87024 101857 87025 66549 31950 43875
         3 Indels: 22416 71783 33266
    Human Gene Mutation Database (HGMD): IRS2

    3 SABiosciences Cancer Mutation PCR Assays for IRS2:
    Cosmic IdAA Change
    32318p.P1036_A1037insP
    26911p.A940T
    27210p.G607D
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRS2
    DNA2.0 Custom Variant and Variant Library Synthesis for IRS2

    Disorders / Diseases
    for IRS2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRS2 for disorders           About GeneDecksing

    OMIM gene information: 600797   
    OMIM disorders: 125853  
    20/58 diseases for IRS2 (see all 58):    About MalaCards
    diabetes mellitus, noninsulin-dependent    glucose intolerance    carbohydrate metabolic disorder    polycystic ovary syndrome
    type 2 diabetes mellitus    diabetes mellitus    insulin resistance    metabolic disorders
    fatty liver disease    retinitis pigmentosa    werner syndrome    essential hypertension
    myocardial infarction    hyperinsulinism    liver disease    hyperandrogenism
    hyperglycemia    multiple myeloma    leiomyosarcoma    colon cancer

    3 diseases from the University of Copenhagen DISEASES database for IRS2:
    Diabetes mellitus     Hyperglycemia     Hyperinsulinism

    10/28 Novoseek disease relationships for IRS2 gene (see all 28)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 77.1 67 15840293 (4), 20092705 (4), 18834442 (3), 12687350 (3) (see all 34)
    insulin sensitivity 61 10 15811564 (3), 12475767 (2), 10525667 (1), 15048126 (1) (see all 5)
    obesity 52.2 16 12687350 (4), 16652127 (2), 20184486 (1), 16086274 (1) (see all 9)
    hyperinsulinemia 47.9 7 17127239 (2), 11259670 (1), 17416760 (1), 14504291 (1) (see all 5)
    niddm 40.7 9 14682250 (2), 14653106 (2), 9758433 (1), 12189449 (1) (see all 5)
    polycystic ovary syndrome 40.3 8 11522686 (2), 15840293 (2), 16037106 (2), 10973656 (1)
    bone loss age-related 37.7 2 15576984 (1), 15651373 (1)
    polycystic ovaries 32.1 2 10973656 (2)
    breast cancer 30.9 40 19261680 (5), 14534541 (4), 16707456 (3), 18819936 (3) (see all 14)
    diabetes gestational 25.3 2 10973656 (2)

    Genetic Association Database (GAD): IRS2
    Human Genome Epidemiology (HuGE) Navigator: IRS2 (55 documents)

    Export disorders for IRS2 gene to outside databases

    Publications
    for IRS2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRS2 gene, integrated from 9 sources (see all 443):
    (articles sorted by number of sources associating them with IRS2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (PubMed id 12687350)1, 2, 4, 9 Lautier C.... Grigorescu F. (2003)
    2. 14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. (PubMed id 9312143)1, 2, 3, 9 Ogihara T.... Asano T. (1997)
    3. Human insulin receptor substrate-2 (IRS-2) is a primary progesterone response gene. (PubMed id 10077005)1, 2, 9 Vassen L.... Klein-Hitpass L. (1999)
    4. The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer. (PubMed id 15308584)1, 4, 9 Wagner K....Forsti A. (2004)
    5. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. (PubMed id 11030756)1, 4, 9 Mammarella S....Cama A. (2000)
    6. Polymorphisms of the insulin receptor substrate-2 in patients with type 2 diabetes. (PubMed id 12519871)1, 4, 9 D'Alfonso R....Sesti G. (2003)
    7. Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms. (PubMed id 12475767)1, 4, 9 Le Fur S....Bougneres P. (2002)
    8. The haplotypes of the IRS-2 gene affect insulin sensitivity in Japanese patients with type 2 diabetes. (PubMed id 15811564)1, 4, 9 Okazawa K....Nakao K. (2005)
    9. Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer. (PubMed id 15247132)1, 4, 9 Slattery M.L....Neuhausen S. (2004)
    10. [Detection of single-nucleotide polymorphisms in insulin receptor substrate-2 gene 3'-untranslated region by denaturing high-performance liquid chromatography] (PubMed id 14653106)1, 4, 9 Zeng W.M....Xie P. (2003)

    External Searches for IRS2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IRS2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8660 HGNC: 6126 AceView: IRS2 Ensembl:ENSG00000185950 euGenes: HUgn8660
    ECgene: IRS2 Kegg: 8660 H-InvDB: IRS2

    Other Databases showing IRS2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IRS2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRS2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for IRS2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for IRS2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IRS2 gene:
    Search GeneIP for patents involving IRS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for IRS2 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

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