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Aliases for IRS2 Gene

Aliases for IRS2 Gene

  • Insulin Receptor Substrate 2 2 3 5
  • IRS-2 3 4

External Ids for IRS2 Gene

Previous GeneCards Identifiers for IRS2 Gene

  • GC13M108766
  • GC13M104793
  • GC13M109242
  • GC13M108132
  • GC13M108104
  • GC13M109204
  • GC13M110406
  • GC13M091005

Summaries for IRS2 Gene

Entrez Gene Summary for IRS2 Gene

  • This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]

GeneCards Summary for IRS2 Gene

IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include Diabetes Mellitus, Noninsulin-Dependent and Gestational Diabetes. Among its related pathways are Development EPO-induced Jak-STAT pathway and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is IRS4.

UniProtKB/Swiss-Prot for IRS2 Gene

  • May mediate the control of various cellular processes by insulin.

Gene Wiki entry for IRS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS2 Gene

Genomics for IRS2 Gene

Regulatory Elements for IRS2 Gene

Enhancers for IRS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRS2 on UCSC Golden Path with GeneCards custom track

Promoters for IRS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IRS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for IRS2 Gene

109,752,698 bp from pter
109,786,568 bp from pter
33,871 bases
Minus strand

Genomic View for IRS2 Gene

Genes around IRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS2 Gene

Proteins for IRS2 Gene

  • Protein details for IRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Insulin receptor substrate 2
    Protein Accession:
    Secondary Accessions:
    • Q96RR2
    • Q9BZG0
    • Q9Y6I5

    Protein attributes for IRS2 Gene

    1338 amino acids
    Molecular mass:
    137334 Da
    Quaternary structure:
    • Interacts with PHIP.

    Three dimensional structures from OCA and Proteopedia for IRS2 Gene

neXtProt entry for IRS2 Gene

Proteomics data for IRS2 Gene at MOPED

Post-translational modifications for IRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRS2 (IRS2)
  • Abcam antibodies for IRS2

No data available for DME Specific Peptides for IRS2 Gene

Domains & Families for IRS2 Gene

Gene Families for IRS2 Gene

Protein Domains for IRS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IRS-type PTB domain.
  • Contains 1 IRS-type PTB domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with IRS2: view

Function for IRS2 Gene

Molecular function for IRS2 Gene

GENATLAS Biochemistry:
insulin receptor substrate 2,pleiotropes mediator of insulin coordinating Igf-1 receptor-mediated beta cell development and peripheral insertion signaling,interacting with several proteins containing SH2 domains,such as PIKRs,GRB2,unlikely to be involved in NIDDM
UniProtKB/Swiss-Prot Function:
May mediate the control of various cellular processes by insulin.

Gene Ontology (GO) - Molecular Function for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005158 insulin receptor binding IEA,IBA --
genes like me logo Genes that share ontologies with IRS2: view
genes like me logo Genes that share phenotypes with IRS2: view

Animal Models for IRS2 Gene

MGI Knock Outs for IRS2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRS2 Gene

Localization for IRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRS2 Gene

Cytoplasm, cytosol.

Subcellular locations from

Jensen Localization Image for IRS2 Gene COMPARTMENTS Subcellular localization image for IRS2 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 4
endoplasmic reticulum 2
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for IRS2 Gene

Pathways & Interactions for IRS2 Gene

SuperPathways for IRS2 Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-7 Signaling Pathways
3 PI3K events in ERBB4 signaling
4 Translation Insulin regulation of translation
5 Longevity regulating pathway - multiple species
genes like me logo Genes that share pathways with IRS2: view

SIGNOR curated interactions for IRS2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for IRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0002903 negative regulation of B cell apoptotic process IEA,ISS --
GO:0006006 glucose metabolic process TAS 9495343
genes like me logo Genes that share ontologies with IRS2: view

Drugs & Compounds for IRS2 Gene

(23) Drugs for IRS2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for IRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IRS2: view

Transcripts for IRS2 Gene

mRNA/cDNA for IRS2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(216) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS2 Gene

Insulin receptor substrate 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRS2 Gene

No ASD Table

Relevant External Links for IRS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRS2 Gene

mRNA expression in normal human tissues for IRS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IRS2 Gene

This gene is overexpressed in Brain (27.8) and Cerebrospinal fluid (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRS2 Gene

SOURCE GeneReport for Unigene cluster for IRS2 Gene Hs.442344

genes like me logo Genes that share expression patterns with IRS2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IRS2 Gene

Orthologs for IRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for IRS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IRS2 35
  • 84.79 (n)
  • 85.02 (a)
IRS2 36
  • 81 (a)
(Canis familiaris)
Mammalia IRS2 35
  • 87.38 (n)
  • 88.79 (a)
IRS2 36
  • 83 (a)
(Mus musculus)
Mammalia Irs2 35
  • 80.8 (n)
  • 84.75 (a)
Irs2 16
Irs2 36
  • 84 (a)
(Pan troglodytes)
Mammalia IRS2 35
  • 97.69 (n)
  • 96.93 (a)
IRS2 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Irs2 35
  • 81.48 (n)
  • 85.69 (a)
(Monodelphis domestica)
Mammalia IRS2 36
  • 73 (a)
(Gallus gallus)
Aves IRS2 35
  • 74.39 (n)
  • 73.72 (a)
IRS2 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498409 35
  • 57.07 (n)
  • 59.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.694 35
(Danio rerio)
Actinopterygii irs2 35
  • 61.73 (n)
  • 60.74 (a)
zgc56306 35
IRS2 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta chico 36
  • 19 (a)
(Oryza sativa)
Liliopsida Os.5303 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for IRS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS2 Gene

Gene Tree for IRS2 (if available)
Gene Tree for IRS2 (if available)

Paralogs for IRS2 Gene

Paralogs for IRS2 Gene

(2) SIMAP similar genes for IRS2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IRS2: view

Variants for IRS2 Gene

Sequence variations from dbSNP and Humsavar for IRS2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1805097 - 109,782,884(-) CCCGG(A/G)CGCCG reference, missense
rs549588978 - 109,783,419(+) GAAGC(C/T)CTCCG reference, missense
rs201499247 - 109,783,409(+) GCTGG(C/G)CCAAG reference, missense
rs35223808 - 109,783,689(-) CCCTG(C/T)ACCCC reference, missense
rs35927012 - 109,783,059(-) ACCCC(A/G)TGGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for IRS2 Gene

Variant ID Type Subtype PubMed ID
dgv348n67 CNV Gain 20364138
nsv526943 CNV Loss 19592680
nsv826791 CNV Loss 20364138
nsv9108 CNV Gain+Loss 18304495
esv2500078 CNV Deletion 19546169
esv2747995 CNV Deletion 23290073
nsv512337 CNV Loss 21212237
esv29023 CNV Gain+Loss 19812545
nsv821265 CNV Deletion 20802225
esv2747997 CNV Deletion 23290073
esv2157648 CNV Deletion 18987734
esv2660355 CNV Deletion 23128226
nsv818995 CNV Gain 17921354
dgv349n67 CNV Gain 20364138
nsv826796 CNV Gain 20364138
esv22887 CNV Loss 19812545
esv2658062 CNV Deletion 23128226

Variation tolerance for IRS2 Gene

Gene Damage Index Score: 6.02; 75.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRS2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRS2 Gene

Disorders for IRS2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for IRS2 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
gestational diabetes
  • gdm
liver disease
  • disorder of liver
fatty liver disease
  • alcoholic fatty liver
insulin-like growth factor i
  • insulin-like growth factor i, resistance to
- elite association - COSMIC cancer census association via MalaCards
Search IRS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRS2 Gene

Publications for IRS2 Gene

  1. Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation. (PMID: 12687350) Lautier C. … Grigorescu F. (Hum. Genet. 2003) 3 4 23 48 67
  2. Identification of a region in the human IRS2 promoter essential for stress induced transcription depending on SP1, NFI binding and ERK activation in HepG2 cells. (PMID: 19755487) Udelhoven M. … Schubert M. (J. Mol. Endocrinol. 2010) 3 23
  3. Neuronal insulin receptor substrate 2 (IRS2) expression is regulated by ZBP89 and SP1 binding to the IRS2 promoter. (PMID: 19875459) Udelhoven M. … Schubert M. (J. Endocrinol. 2010) 3 23
  4. The IRS2 Gly1057Asp variant is associated with human longevity. (PMID: 19887537) Barbieri M. … Paolisso G. (J. Gerontol. A Biol. Sci. Med. Sci. 2010) 3 23
  5. [Expression of insulin receptor substrate-2 and its tyrosine phosphorylation in the hepatic tissue of chronic hepatitis B patients]. (PMID: 20092705) Zhu Q.R. … Liu H.Q. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2010) 3 23

Products for IRS2 Gene

Sources for IRS2 Gene