External Ids for IRS2 Gene
Previous GeneCards Identifiers for IRS2 Gene
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRS2 Gene
IRS2 (Insulin Receptor Substrate 2) is a Protein Coding gene. Diseases associated with IRS2 include Diabetes Mellitus, Noninsulin-Dependent and Fatty Liver Disease. Among its related pathways are PI-3K cascade-FGFR3 and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include protein kinase binding and protein domain specific binding. An important paralog of this gene is IRS1.
UniProtKB/Swiss-Prot for IRS2 Gene
May mediate the control of various cellular processes by insulin.