Aliases for IRS1 Gene
External Ids for IRS1 Gene
- HGNC: 6125
- Entrez Gene: 3667
- Ensembl: ENSG00000169047
- OMIM: 147545
- UniProtKB: P35568
Previous GeneCards Identifiers for IRS1 Gene
- GC02M225622
- GC02M226321
- GC02M227563
- GC02M227802
- GC02M227425
- GC02M227308
- GC02M219439
Summaries for IRS1 Gene
-
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
GeneCards Summary for IRS1 Gene
IRS1 (Insulin Receptor Substrate 1) is a Protein Coding gene. Diseases associated with IRS1 include Diabetes Mellitus, Noninsulin-Dependent and Diabetes Mellitus. Among its related pathways are RET signaling and Metformin Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein kinase C binding. An important paralog of this gene is IRS2.
UniProtKB/Swiss-Prot for IRS1 Gene
-
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Additional gene information for IRS1 Gene
- Monarch Initiative
- Search for IRS1 at DataMed
- Search for IRS1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS1 Gene
Genomics for IRS1 Gene
GeneHancer (GH) Regulatory Elements for IRS1 Gene
Regulatory Element Products
Genomic Locations for IRS1 Gene
- chr2:226,731,317-226,799,759
- (GRCh38/hg38)
- Size:
- 68,443 bases
- Orientation:
- Minus strand
- chr2:227,596,033-227,664,475
- (GRCh37/hg19)
Genomic View for IRS1 Gene
- Cytogenetic band:
-
- 2q36.3 by Ensembl
- 2q36.3 by Entrez Gene
- 2q36.3 by HGNC


RefSeq DNA sequence for IRS1 Gene
Proteins for IRS1 Gene
-
Protein details for IRS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35568-IRS1_HUMAN
- Recommended name:
- Insulin receptor substrate 1
- Protein Accession:
- P35568
Protein attributes for IRS1 Gene
- Size:
- 1242 amino acids
- Molecular mass:
- 131591 Da
- Quaternary structure:
-
- Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK. Interacts with EIF2AK2/PKR (By similarity).
Protein Expression for IRS1 Gene
Post-translational modifications for IRS1 Gene
- Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
- Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).
Other Protein References for IRS1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IRS1 (IRS1)
- Cell Signaling Technology (CST) Antibodies for IRS1 (IRS1)
-
Custom Antibody ServicesOriGene Antibodies for IRS1
- AM12122PU-N
- AP00164PU-N
- AP01831PU-N
- AP02428PU-N
- CF808553
- TA808553
- CF808552
- TA808552
- CF808551
- TA808551
- CF808550
- TA808550
- TA353883
- TA349369
- TA327864
- TA327805
- TA325575
- TA325574
- TA325573
- TA325572
- TA322594
- TA322593
- TA322592
- TA319246
- TA312871
- TA312870
- TA312869
- TA312868
- TA312866
- TA312859
- TA312858
- TA309986
- TA306226
- TA303552
- AP31339PU-N
- AP22717PU-N
- AP21042PU-N
- AP20954PU-N
- AP20832PU-N
- AP20831PU-N
- AP20817PU-N
- AP20710PU-N
- AP20709PU-N
- AP20695PU-N
- AP20694PU-N
- AP07321PU-N
- AP06529PU-N
- AP06432PU-N
- AP06397PU-N
- AP02733PU-S
- AP02733PU-N
- AP02732PU-S
- AP02732PU-N
- AP02489PU-S
- AP02489PU-N
- AP02488PU-S
- AP02488PU-N
- AP02428PU-S
- Novus Biologicals Antibodies for IRS1
-
Abcam antibodies for IRS1
-
Cloud-Clone Corp. Antibodies for IRS1
- Invitrogen Antibodies for IRS1
- antibodies-online: Search results for 598 available IRS1 Antibodies ranked by validation data
- Compare Top IRS1 Antibodies
-
Recommended
- 2 ICS Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 29 IHC Antibodies (anti-rat)
- 33 IHC (p) Antibodies (anti-rat)
- 108 IF (p) Antibodies (anti-rat)
- 213 WB Antibodies (anti-rat)
- 2 ICS Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 33 IHC (p) Antibodies (anti-mouse)
- 33 IHC Antibodies (anti-mouse)
- 108 IF (p) Antibodies (anti-mouse)
- 233 WB Antibodies (anti-mouse)
- 1 IP Antibody (anti-human)
- 1 EIA Antibody (anti-human)
- 2 ICS Antibodies (anti-human)
- 40 IHC Antibodies (anti-human)
- 52 IHC (p) Antibodies (anti-human)
- 120 IF (p) Antibodies (anti-human)
- 319 WB Antibodies (anti-human)
- GeneTex IRS1 antibody for IRS1
-
Custom Antibody ServicesProSci Antibodies for IRS1
-
Santa Cruz Biotechnology (SCBT) Antibodies for IRS1
Protein Products
-
OriGene Purified Proteins for IRS1
- Search Origene for MassSpec and Protein Over-expression Lysates for IRS1
- Origene Custom Protein Services for IRS1
-
Cloud-Clone Corp. Proteins for IRS1
- Search GeneTex for Proteins for IRS1
-
Abcam proteins for IRS1
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for IRS1 (IRS1)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for IRS1 (IRS1)
-
Cloud-Clone Corp. Assay Kits for IRS1
No data available for DME Specific Peptides for IRS1 Gene
Domains & Families for IRS1 Gene
Gene Families for IRS1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IRS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IRS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for IRS1 Gene
Function for IRS1 Gene
Molecular function for IRS1 Gene
- GENATLAS Biochemistry:
- insulin receptor,substrate 1,overexpressed in skeletal muscle,and adipocytes (polymorphism associated to susceptibility to NIDDM),located in the low density microsome fraction,tyrosine phosphorylated in response to insulin stimulation,interacting with several proteins containing SH2 domains,such as PIKRs,GRB2
- UniProtKB/Swiss-Prot Function:
- May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Phenotypes From GWAS Catalog for IRS1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001784 | phosphotyrosine residue binding | IPI | 20624904 |
GO:0004871 | signal transducer activity | TAS | 1311924 |
GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity | TAS,ISS | -- |
GO:0005080 | protein kinase C binding | ISS | -- |
GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for IRS1 Gene
- MGI mutant phenotypes for IRS1:
-
inferred from 9 alleles
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for IRS1:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- Decreased viability
- Decreased Salmonella enterica Typhimurium invasion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased HPV16-GFP infection
- Increased cell number in S
- Increased cell death HMECs cells
- Increased Sindbis virus (SINV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IRS1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IRS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IRS1 gene
- Search ViGene Biosciences for IRS1
CRISPR Products
-
OriGene CRISPR knockouts for IRS1
- genomics-online: gRNA clones - Search results for available IRS1 gene related products
- Applied Biological Materials CRISPR for IRS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRS1
- GenScript: Design CRISPR guide RNA sequences for IRS1
miRNA for IRS1 Gene
- miRTarBase miRNAs that target IRS1
-
- hsa-mir-145-5p (MIRT000731)
- hsa-mir-7-5p (MIRT003807)
- hsa-mir-126-3p (MIRT004355)
- hsa-mir-148a-3p (MIRT006859)
- hsa-mir-152-3p (MIRT006860)
- ssc-mir-145-5p (MIRT054038)
- hsa-mir-105-5p (MIRT437910)
- hsa-mir-4480 (MIRT442208)
- hsa-mir-4311 (MIRT442210)
- hsa-mir-1277-5p (MIRT542213)
- hsa-mir-4789-5p (MIRT542214)
- hsa-mir-3941 (MIRT542215)
- hsa-mir-223-5p (MIRT542216)
- hsa-mir-511-3p (MIRT542217)
- hsa-mir-5011-5p (MIRT542218)
- hsa-mir-4789-3p (MIRT542219)
- hsa-mir-5580-3p (MIRT542220)
- hsa-mir-603 (MIRT542221)
- hsa-mir-362-3p (MIRT542222)
- hsa-mir-8485 (MIRT542223)
- hsa-mir-329-3p (MIRT542224)
- hsa-mir-190a-3p (MIRT544956)
- hsa-mir-6867-5p (MIRT556913)
- hsa-mir-1185-2-3p (MIRT623572)
- hsa-mir-1185-1-3p (MIRT623573)
- hsa-let-7f-2-3p (MIRT623574)
- hsa-mir-7157-5p (MIRT623575)
- hsa-mir-4310 (MIRT623576)
- hsa-mir-3120-3p (MIRT623577)
- hsa-mir-4777-3p (MIRT667814)
- hsa-mir-892c-3p (MIRT711049)
- hsa-mir-4676-3p (MIRT711050)
- hsa-mir-452-5p (MIRT711051)
- hsa-mir-429 (MIRT711052)
- hsa-mir-200c-3p (MIRT711053)
- hsa-mir-200b-3p (MIRT711054)
- hsa-mir-1225-5p (MIRT732116)
- hsa-mir-144-3p (MIRT734527)
- hsa-mir-628-5p (MIRT735025)
- hsa-mir-384 (MIRT735485)
miRNA Products
- Search ViGene Biosciences for IRS1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IRS1
- Browse OriGene Inhibitory RNA Products For IRS1
- genomics-online: shRNA clones - Search results for available IRS1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IRS1 gene
Clone Products
- Sino Biological Human cDNA Clone for IRS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IRS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IRS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IRS1
- genomics-online: cdna clones - Search results for available IRS1 gene related products
- orf clones - Search results for available IRS1 gene related products
- Applied Biological Materials Clones for IRS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IRS1
Cell Line Products
-
Horizon Cell Lines for IRS1
-
ViGene Biosciences adenoviral particle packaged cDNA for IRS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IRS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IRS1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IRS1 Gene
Localization for IRS1 Gene
- Cytosol (3)
- Nucleoplasm (3)
- Plasma membrane (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | ISS,TAS | -- |
GO:0005829 | cytosol | TAS,IBA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005899 | insulin receptor complex | ISS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRS1 Gene
Pathways & Interactions for IRS1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Regulation of lipid metabolism Insulin signaling-generic cascades |
.01
|
|
3 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
4 | PI3K/AKT activation |
.89
|
|
5 | IL-2 Pathway |
.34
|
Pathways by source for IRS1 Gene
1 GeneTex pathway for IRS1 Gene
2 Cell Signaling Technology pathways for IRS1 Gene
29 BioSystems pathways for IRS1 Gene
63 Reactome pathways for IRS1 Gene
2 PharmGKB pathways for IRS1 Gene
17 KEGG pathways for IRS1 Gene
22 GeneGo (Thomson Reuters) pathways for IRS1 Gene
11 R&D Systems pathways for IRS1 Gene
19 Qiagen pathways for IRS1 Gene
Interacting Proteins for IRS1 Gene
SIGNOR curated interactions for IRS1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007165 | signal transduction | TAS | 1311924 |
GO:0008284 | positive regulation of cell proliferation | NAS | 17925406 |
GO:0008286 | insulin receptor signaling pathway | IMP,IPI | 7537849 |
GO:0010907 | positive regulation of glucose metabolic process | IMP | 16814735 |
Drugs & Compounds for IRS1 Gene
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Transcripts for IRS1 Gene
mRNA/cDNA for IRS1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (115) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IRS1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IRS1
- genomics-online: gRNA clones - Search results for available IRS1 gene related products
- Applied Biological Materials CRISPR for IRS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IRS1
- GenScript: Design CRISPR guide RNA sequences for IRS1
miRNA Products
- Search ViGene Biosciences for IRS1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IRS1
- Browse OriGene Inhibitory RNA Products For IRS1
- genomics-online: shRNA clones - Search results for available IRS1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IRS1 gene
Clone Products
- Sino Biological Human cDNA Clone for IRS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IRS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IRS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IRS1
- genomics-online: cdna clones - Search results for available IRS1 gene related products
- orf clones - Search results for available IRS1 gene related products
- Applied Biological Materials Clones for IRS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IRS1
Expression for IRS1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T-Cytotoxic Cells Peripheral Blood
- Double Positive Thymocytes Thymus
- Mature B-Cells Peripheral Blood
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Thyroid (Endocrine System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IRS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of IRS1 Gene:
IRS1SOURCE GeneReport for Unigene cluster for IRS1 Gene:
Hs.471508Evidence on tissue expression from TISSUES for IRS1 Gene
- Liver(4.7)
- Muscle(4.7)
- Eye(4.3)
- Nervous system(3.4)
- Pancreas(2.6)
- Blood(2.5)
- Heart(2.3)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for IRS1
-
OriGene qPCR primer pairs and template standards for IRS1
- genomics-online: primer clones - Search results for available IRS1 gene related products
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRS1 Gene
Orthologs for IRS1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | IRS1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | IRS1 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | IRS1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Irs1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Irs1 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | IRS1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | IRS1 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | IRS1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495320 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.957 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | irs1 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | chico 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for IRS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IRS1 Gene
(1) SIMAP similar genes for IRS1 Gene using alignment to 4 proteins:
Variants for IRS1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IRS1 Gene
- IRS1_HUMAN-P35568
- The Arg-971 polymorphism impairs the ability of insulin to stimulate glucose transport, glucose transporter translocation, and glycogen synthesis by affecting the PI3K/AKT1/GSK3 signaling pathway. The polymorphism at Arg-971 may contribute to the in vivo insulin resistance observed in carriers of this variant. Arg-971 could contribute to the risk for atherosclerotic cardiovascular diseases associated with non-insulin-dependent diabetes mellitus (NIDDM) by producing a cluster of insulin resistance-related metabolic abnormalities. In insulin-stimulated human endothelial cells from carriers of the Arg-971 polymorphism, genetic impairment of the IRS1/PI3K/PDPK1/AKT1 insulin signaling cascade results in impaired insulin-stimulated nitric oxide (NO) release and suggested that this may be a mechanism through which the Arg-971 polymorphism contributes to the genetic predisposition to develop endothelial dysfunction and cardiovascular disease. The Arg-971 polymorphism not only reduces phosphorylation of the substrate but allows IRS1 to act as an inhibitor of PI3K, producing global insulin resistance.
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs104893642 | pathogenic, Diabetes mellitus type 2 | 226,796,916(-) | G/A/C | coding_sequence_variant, missense_variant | |
rs148962208 | uncertain-significance, Diabetes mellitus type 2 | 226,795,504(-) | G/A | coding_sequence_variant, missense_variant | |
rs1801278 | risk-factor, Insulin resistance, susceptibility to, Coronary artery disease, susceptibility to | 226,795,828(-) | C/G/T | coding_sequence_variant, missense_variant | |
VAR_005302 | Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853] | p.Ser1043Tyr | |||
VAR_005303 | Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853] | p.Cys1095Tyr |
Additional Variant Information for IRS1 Gene
Disorders for IRS1 Gene

(20) MalaCards diseases for IRS1 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, Novoseek, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
diabetes mellitus, noninsulin-dependent |
|
|
diabetes mellitus |
|
|
mixed cell adenoma |
|
|
gestational diabetes |
|
|
polycystic ovary syndrome |
|
UniProtKB/Swiss-Prot
IRS1_HUMAN- Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:10206679, ECO:0000269 PubMed:12843189, ECO:0000269 PubMed:8723689}. Note=The gene represented in this entry may be involved in disease pathogenesis.
Additional Disease Information for IRS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for IRS1 Gene
Publications for IRS1 Gene
- A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. (PMID: 12679424) Esposito DL … Cama A (The Journal of clinical endocrinology and metabolism 2003) 3 4 22 44 58
- Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. (PMID: 8104271) Almind K … Pedersen O (Lancet (London, England) 1993) 3 4 22 44 58
- [Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatán, México]. (PMID: 19418728) García-Escalante MG … Laviada-Molina H (Investigacion clinica 2009) 3 22 44 58
- S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. (PMID: 18952604) Zhang J … Ye J (The Journal of biological chemistry 2008) 3 4 22 58
- Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. (PMID: 18059035) Slattery ML … Potter JD (International journal of cancer 2008) 3 22 44 58
Products for IRS1 Gene
- R&D Systems Antibodies for IRS1 (IRS1)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for IRS1 (IRS1)
- R&D Systems cDNA Clones for IRS1
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for IRS1
- AM12122PU-N
- AP00164PU-N
- AP01831PU-N
- AP02428PU-N
- AP02428PU-S
- AP02488PU-N
- AP02488PU-S
- AP02489PU-N
- AP02489PU-S
- AP02732PU-N
- AP02732PU-S
- AP02733PU-N
- AP02733PU-S
- AP06397PU-N
- AP06432PU-N
- AP06529PU-N
- AP07321PU-N
- AP20694PU-N
- AP20695PU-N
- AP20709PU-N
- AP20710PU-N
- AP20817PU-N
- AP20831PU-N
- AP20832PU-N
- AP20954PU-N
- AP21042PU-N
- AP22717PU-N
- AP31339PU-N
- TA303552
- TA306226
- TA309986
- TA312858
- TA312859
- TA312866
- TA312868
- TA312869
- TA312870
- TA312871
- TA319246
- TA322592
- TA322593
- TA322594
- TA325572
- TA325573
- TA325574
- TA325575
- TA327805
- TA327864
- TA349369
- TA353883
- TA808550
- CF808550
- TA808551
- CF808551
- TA808552
- CF808552
- TA808553
- CF808553
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for IRS1
- Search Origene for MassSpec and Protein Over-expression Lysates for IRS1
- Origene Custom Protein Services for IRS1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IRS1
- Browse OriGene Inhibitory RNA Products For IRS1
- OriGene qPCR primer pairs and template standards for IRS1
- OriGene qPCR primer pairs for IRS1
- OriGene CRISPR knockouts for IRS1
- OriGene ORF clones in human for IRS1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For IRS1
- GenScript: Next-day shipping of latest version cDNA ORF clones for IRS1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for IRS1
- GenScript Custom Assay Services for IRS1
- GenScript Custom overexpressing Cell Line Services for IRS1
- GenScript: Design CRISPR guide RNA sequences for IRS1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IRS1
- Cell Signaling Technology (CST) Antibodies for IRS1 (IRS1)
- Cell Signaling Technology (CST) Sandwich ELISA Kits for IRS1 (IRS1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for IRS1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for IRS1
- Novus Biologicals proteins and lysates for IRS1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for IRS1
- Abcam proteins for IRS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for IRS1
- Cloud-Clone Corp. Proteins for IRS1
- Cloud-Clone Corp. Assay Kits for IRS1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for IRS1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for IRS1
- VectorBuilder custom plasmid, inducible vectors for IRS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IRS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IRS1
- antibodies-online: Search results for 598 available IRS1 Antibodies ranked by validation data
- Compare Top IRS1 Antibodies
- Recommended
- 319 WB Antibodies (anti-human)
- 120 IF (p) Antibodies (anti-human)
- 52 IHC (p) Antibodies (anti-human)
- 40 IHC Antibodies (anti-human)
- 2 ICS Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 IP Antibody (anti-human)
- 233 WB Antibodies (anti-mouse)
- 108 IF (p) Antibodies (anti-mouse)
- 33 IHC Antibodies (anti-mouse)
- 33 IHC (p) Antibodies (anti-mouse)
- 2 IP Antibodies (anti-mouse)
- 2 ICS Antibodies (anti-mouse)
- 213 WB Antibodies (anti-rat)
- 108 IF (p) Antibodies (anti-rat)
- 33 IHC (p) Antibodies (anti-rat)
- 29 IHC Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 ICS Antibodies (anti-rat)
- antibodies-online: Search results for 50 available IRS1 Elisa Kits ranked by validation data
- Compare Top IRS1 Elisa Kits
- antibodies-online: Search results for 6 available IRS1 Proteins ranked by validation data
- Compare Top IRS1 Proteins
- GeneTex IRS1 antibody for IRS1
- Search GeneTex for Proteins for IRS1
- ViGene Biosciences adenoviral particle packaged cDNA for IRS1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IRS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IRS1 gene
- Search ViGene Biosciences for IRS1
- Santa Cruz Biotechnology (SCBT) Antibodies for IRS1
- Search Santa Cruz Biotechnology (SCBT) for IRS1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IRS1
- Custom Antibody ServicesProSci Antibodies for IRS1
- Search for IRS1 Proteins at ProSci
- Horizon Cell Lines for IRS1
- genomics-online: cdna clones - Search results for available IRS1 gene related products
- orf clones - Search results for available IRS1 gene related products
- genomics-online: gRNA clones - Search results for available IRS1 gene related products
- genomics-online: primer clones - Search results for available IRS1 gene related products
- genomics-online: shRNA clones - Search results for available IRS1 gene related products
Sources for IRS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94)