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Aliases for IRS1 Gene

Aliases for IRS1 Gene

  • Insulin Receptor Substrate 1 2 3
  • IRS-1 3 4
  • HIRS-1 3

External Ids for IRS1 Gene

Summaries for IRS1 Gene

Entrez Gene Summary for IRS1 Gene

  • This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]

GeneCards Summary for IRS1 Gene

IRS1 (Insulin Receptor Substrate 1) is a Protein Coding gene. Diseases associated with IRS1 include leprechaunism and insulin-like growth factor i. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include phospholipid binding and protein kinase C binding. An important paralog of this gene is IRS4.

UniProtKB/Swiss-Prot for IRS1 Gene

  • May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Gene Wiki entry for IRS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRS1 Gene

Genomics for IRS1 Gene

Genomic Location for IRS1 Gene

Start:
226,731,317 bp from pter
End:
226,799,829 bp from pter
Size:
68,513 bases
Orientation:
Minus strand

Genomic View for IRS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRS1 Gene

Regulatory Elements for IRS1 Gene

Proteins for IRS1 Gene

  • Protein details for IRS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35568-IRS1_HUMAN
    Recommended name:
    Insulin receptor substrate 1
    Protein Accession:
    P35568
    Secondary Accessions:

    Protein attributes for IRS1 Gene

    Size:
    1242 amino acids
    Molecular mass:
    131591 Da
    Quaternary structure:
    • Interacts with UBTF and PIK3CA (By similarity). Interacts (via phosphorylated YXXM motifs) with PIK3R1 (By similarity). Interacts with ROCK1 and FER (By similarity). Interacts (via PH domain) with PHIP (By similarity). Interacts with GRB2 (By similarity). Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK. Interacts with EIF2AK2/PKR (By similarity).

    Three dimensional structures from OCA and Proteopedia for IRS1 Gene

neXtProt entry for IRS1 Gene

Proteomics data for IRS1 Gene at MOPED

Post-translational modifications for IRS1 Gene

  • Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity). Phosphorylated by ALK. Phosphorylated at Ser-270, Ser-307, Ser-636 and Ser-1101 by RPS6KB1; phosphorylation induces accelerated degradation of IRS1.
  • Ubiquitinated by the Cul7-RING(FBXW8) complex in a mTOR-dependent manner, leading to its degradation: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRS1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for IRS1 Gene

Domains for IRS1 Gene

Gene Families for IRS1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing

UniProtKB/Swiss-Prot:

IRS1_HUMAN
Domain:
  • Contains 1 IRS-type PTB domain.:
    • P35568
  • Contains 1 PH domain.:
    • P35568
genes like me logo Genes that share domains with IRS1: view

Function for IRS1 Gene

Molecular function for IRS1 Gene

GENATLAS Biochemistry: insulin receptor,substrate 1,overexpressed in skeletal muscle,and adipocytes (polymorphism associated to susceptibility to NIDDM),located in the low density microsome fraction,tyrosine phosphorylated in response to insulin stimulation,interacting with several proteins containing SH2 domains,such as PIKRs,GRB2
UniProtKB/Swiss-Prot Function: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Gene Ontology (GO) - Molecular Function for IRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity ISS --
GO:0005080 protein kinase C binding ISS --
GO:0005158 insulin receptor binding IPI 7493946
GO:0005159 insulin-like growth factor receptor binding IPI 7541045
genes like me logo Genes that share ontologies with IRS1: view
genes like me logo Genes that share phenotypes with IRS1: view

Animal Models for IRS1 Gene

MGI Knock Outs for IRS1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IRS1 Gene

Localization for IRS1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRS1 Gene COMPARTMENTS Subcellular localization image for IRS1 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for IRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0005899 insulin receptor complex ISS --
genes like me logo Genes that share ontologies with IRS1: view

Pathways for IRS1 Gene

SuperPathways for IRS1 Gene

Superpath Contained pathways
1 PI-3K cascade
2 Signaling by FGFR
3 Insulin receptor signalling cascade
4 IL-9 Signaling Pathways
5 Translation Insulin regulation of translation
genes like me logo Genes that share pathways with IRS1: view

Gene Ontology (GO) - Biological Process for IRS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002053 positive regulation of mesenchymal cell proliferation IEA --
GO:0007165 signal transduction TAS 1311924
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008284 positive regulation of cell proliferation NAS 17925406
GO:0008286 insulin receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with IRS1: view

Compounds for IRS1 Gene

(1) Drugbank Compounds for IRS1 Gene

(87) Novoseek inferred chemical compound relationships for IRS1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 90.7 203
tyrosine 87.3 270
glucose 78.9 155
phosphotyrosine 77.5 53
glycogen 76.2 72
genes like me logo Genes that share compounds with IRS1: view

Transcripts for IRS1 Gene

mRNA/cDNA for IRS1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(115) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRS1 Gene

Insulin receptor substrate 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRS1 Gene

No ASD Table

Relevant External Links for IRS1 Gene

GeneLoc Exon Structure for
IRS1
ECgene alternative splicing isoforms for
IRS1

Expression for IRS1 Gene

mRNA expression in normal human tissues for IRS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRS1 Gene

SOURCE GeneReport for Unigene cluster for IRS1 Gene Hs.471508

genes like me logo Genes that share expressions with IRS1: view

Orthologs for IRS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRS1 36
  • 99.19 (n)
  • 98.87 (a)
IRS1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRS1 36
  • 88.74 (n)
  • 91.01 (a)
IRS1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRS1 36
  • 88.97 (n)
  • 91.76 (a)
IRS1 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irs1 36
  • 85.37 (n)
  • 89.17 (a)
Irs1 16
Irs1 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRS1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irs1 36
  • 84.97 (n)
  • 89.1 (a)
chicken
(Gallus gallus)
Aves IRS1 36
  • 74.2 (n)
  • 79.78 (a)
IRS1 37
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRS1 37
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.957 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495320 36
  • 62.74 (n)
  • 69.99 (a)
zebrafish
(Danio rerio)
Actinopterygii irs1 36
  • 61.99 (n)
  • 65.38 (a)
irs1 37
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta chico 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for IRS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRS1 Gene

ENSEMBL:
Gene Tree for IRS1 (if available)
TreeFam:
Gene Tree for IRS1 (if available)

Paralogs for IRS1 Gene

Paralogs for IRS1 Gene

Selected SIMAP similar genes for IRS1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with IRS1: view

Variants for IRS1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IRS1 Gene

P35568-IRS1_HUMAN
The Arg-971 polymorphism impairs the ability of insulin to stimulate glucose transport, glucose transporter translocation, and glycogen synthesis by affecting the PI3K/AKT1/GSK3 signaling pathway. The polymorphism at Arg-971 may contribute to the in vivo insulin resistance observed in carriers of this variant. Arg-971 could contribute to the risk for atherosclerotic cardiovascular diseases associated with non-insulin-dependent diabetes mellitus (NIDDM) by producing a cluster of insulin resistance-related metabolic abnormalities. In insulin-stimulated human endothelial cells from carriers of the Arg-971 polymorphism, genetic impairment of the IRS1/PI3K/PDPK1/AKT1 insulin signaling cascade results in impaired insulin-stimulated nitric oxide (NO) release and suggested that this may be a mechanism through which the Arg-971 polymorphism contributes to the genetic predisposition to develop endothelial dysfunction and cardiovascular disease. The Arg-971 polymorphism not only reduces phosphorylation of the substrate but allows IRS1 to act as an inhibitor of PI3K, producing global insulin resistance

Sequence variations from dbSNP and Humsavar for IRS1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10203 -- 226,793,170(+) CAATT(C/T)TCTTC intron-variant
rs15625 -- 226,736,165(-) AGGAC(C/T)TCATA utr-variant-3-prime
rs919423 -- 226,755,850(+) TAATC(C/T)AACAG intron-variant
rs1025333 -- 226,780,809(+) TTTTT(A/T)AAATA intron-variant
rs1078533 -- 226,765,871(+) TTACA(A/C)TAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRS1 Gene

Variant ID Type Subtype PubMed ID
nsv3190 CNV Loss 18451855
nsv875921 CNV Loss 21882294
nsv821910 CNV Gain 20364138

Relevant External Links for IRS1 Gene

HapMap Linkage Disequilibrium report
IRS1
Human Gene Mutation Database (HGMD)
IRS1

Disorders for IRS1 Gene

(1) OMIM Diseases for IRS1 Gene (147545)

UniProtKB/Swiss-Prot

IRS1_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:10206679, ECO:0000269 PubMed:12843189, ECO:0000269 PubMed:8723689}. Note=The gene represented in this entry may be involved in disease pathogenesis.

(4) University of Copenhagen DISEASES for IRS1 Gene

(64) Novoseek inferred disease relationships for IRS1 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 89.1 152
insulin sensitivity 79.2 33
niddm 67.8 91
hyperinsulinemia 64.6 19
obesity 61.5 44

Relevant External Links for IRS1

Genetic Association Database (GAD)
IRS1
Human Genome Epidemiology (HuGE) Navigator
IRS1
genes like me logo Genes that share disorders with IRS1: view

Publications for IRS1 Gene

  1. Aminoacid polymorphisms of insulin receptor substrate-1 in non- insulin-dependent diabetes mellitus. (PMID: 8104271) Almind K. … Pedersen O. (Lancet 1993) 3 4 23 49
  2. A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. (PMID: 12679424) Esposito D.L. … Cama A. (J. Clin. Endocrinol. Metab. 2003) 3 4 23 49
  3. The Arg(972) variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. (PMID: 12843189) Marini M.A. … Sesti G. (J. Clin. Endocrinol. Metab. 2003) 3 4 23 49
  4. [Polymorphism of insulin receptor substrate-1 gene in patients with coronary heart diseases]. (PMID: 12910680) Liu R. … Liu B. (Sichuan Da Xue Xue Bao Yi Xue Ban 2003) 3 23 49
  5. The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians. (PMID: 14633864) Kovacs P. … Baier L.J. (Diabetes 2003) 3 23 49

Products for IRS1 Gene

  • Addgene plasmids for IRS1

Sources for IRS1 Gene

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