Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IRGQ Gene

Aliases for IRGQ Gene

  • Immunity Related GTPase Q 2 3
  • Immunity-Related GTPase Family, Q1 2 3
  • IRGQ1 3 4
  • Immunity-Related GTPase Family Q Protein 3
  • Immunity-Related GTPase Family, Q 3
  • Immunity-Related GTPase Q 5
  • FKSG27 3

External Ids for IRGQ Gene

Previous HGNC Symbols for IRGQ Gene

  • IRGQ1

Previous GeneCards Identifiers for IRGQ Gene

  • GC19M048792
  • GC19M044090
  • GC19M040519

Summaries for IRGQ Gene

GeneCards Summary for IRGQ Gene

IRGQ (Immunity Related GTPase Q) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRGQ Gene

Genomics for IRGQ Gene

Regulatory Elements for IRGQ Gene

Enhancers for IRGQ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around IRGQ on UCSC Golden Path with GeneCards custom track

Promoters for IRGQ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for IRGQ Gene

43,584,367 bp from pter
43,596,229 bp from pter
11,863 bases
Minus strand

Genomic View for IRGQ Gene

Genes around IRGQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRGQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRGQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRGQ Gene

Proteins for IRGQ Gene

  • Protein details for IRGQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunity-related GTPase family Q protein
    Protein Accession:
    Secondary Accessions:
    • B2RNP3

    Protein attributes for IRGQ Gene

    623 amino acids
    Molecular mass:
    62717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRGQ Gene

Post-translational modifications for IRGQ Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRGQ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRGQ Gene

Domains & Families for IRGQ Gene

Protein Domains for IRGQ Gene


Suggested Antigen Peptide Sequences for IRGQ Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
genes like me logo Genes that share domains with IRGQ: view

No data available for Gene Families for IRGQ Gene

Function for IRGQ Gene

Gene Ontology (GO) - Molecular Function for IRGQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IRGQ: view

Phenotypes for IRGQ Gene

genes like me logo Genes that share phenotypes with IRGQ: view

Animal Model Products

CRISPR Products

miRNA for IRGQ Gene

miRTarBase miRNAs that target IRGQ

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRGQ Gene

Localization for IRGQ Gene

Subcellular locations from

Jensen Localization Image for IRGQ Gene COMPARTMENTS Subcellular localization image for IRGQ gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IRGQ Gene

Pathways & Interactions for IRGQ Gene

SuperPathways for IRGQ Gene

No Data Available

Interacting Proteins for IRGQ Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000387535 Q8WZA9-IRGQ_HUMAN for IRGQ Gene via STRING IID

Gene Ontology (GO) - Biological Process for IRGQ Gene


No data available for Pathways by source and SIGNOR curated interactions for IRGQ Gene

Drugs & Compounds for IRGQ Gene

No Compound Related Data Available

Transcripts for IRGQ Gene

Unigene Clusters for IRGQ Gene

Immunity-related GTPase family, Q:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRGQ Gene

No ASD Table

Relevant External Links for IRGQ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRGQ Gene

mRNA expression in normal human tissues for IRGQ Gene

Protein differential expression in normal tissues from HIPED for IRGQ Gene

This gene is overexpressed in Fetal Brain (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IRGQ Gene

Protein tissue co-expression partners for IRGQ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRGQ Gene:


SOURCE GeneReport for Unigene cluster for IRGQ Gene:

genes like me logo Genes that share expression patterns with IRGQ: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for IRGQ Gene

Orthologs for IRGQ Gene

This gene was present in the common ancestor of mammals.

Orthologs for IRGQ Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IRGQ 34
  • 82.31 (n)
  • 84.03 (a)
  • 84 (a)
(Canis familiaris)
Mammalia IRGQ 34
  • 83.28 (n)
  • 85.48 (a)
  • 84 (a)
(Mus musculus)
Mammalia Irgq 34
  • 79.61 (n)
  • 83.68 (a)
Irgq 16
Irgq 35
  • 83 (a)
(Pan troglodytes)
Mammalia IRGQ 34
  • 99.41 (n)
  • 99.52 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Irgq 34
  • 79.32 (n)
  • 83.68 (a)
Species where no ortholog for IRGQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IRGQ Gene

Gene Tree for IRGQ (if available)
Gene Tree for IRGQ (if available)

Paralogs for IRGQ Gene

No data available for Paralogs for IRGQ Gene

Variants for IRGQ Gene

Sequence variations from dbSNP and Humsavar for IRGQ Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10682090 -- 43,591,856(+) AAAAG(-/AA)AAAAA utr-variant-3-prime
rs28444861 -- 43,591,855(+) AAAAA(A/G)AAAAA utr-variant-3-prime
rs28516671 -- 43,589,832(+) GATAC(A/G)TGAGC utr-variant-3-prime
rs77878142 -- 43,590,202(+) ATTTC(A/C)AAAAA utr-variant-3-prime
rs3817 -- 43,586,043(+) CCTCC(A/C)TCATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for IRGQ Gene

Variant ID Type Subtype PubMed ID
dgv3603n100 CNV gain 25217958
nsv833839 CNV loss 17160897

Variation tolerance for IRGQ Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRGQ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRGQ Gene

Disorders for IRGQ Gene

Relevant External Links for IRGQ

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for IRGQ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRGQ Gene

Publications for IRGQ Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 65
  2. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. (PMID: 16277747) Bekpen C. … Howard J.C. (Genome Biol. 2005) 2 3 65
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for IRGQ Gene

Sources for IRGQ Gene

Loading form....