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Aliases for IRGQ Gene

Aliases for IRGQ Gene

  • Immunity Related GTPase Q 2 3 5
  • Immunity-Related GTPase Family, Q1 2 3
  • IRGQ1 3 4
  • Immunity-Related GTPase Family Q Protein 3
  • Immunity-Related GTPase Family, Q 3
  • FKSG27 3

External Ids for IRGQ Gene

Previous HGNC Symbols for IRGQ Gene

  • IRGQ1

Previous GeneCards Identifiers for IRGQ Gene

  • GC19M048792
  • GC19M044090
  • GC19M040519

Summaries for IRGQ Gene

GeneCards Summary for IRGQ Gene

IRGQ (Immunity Related GTPase Q) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include GTP binding.

Additional gene information for IRGQ Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRGQ Gene

Genomics for IRGQ Gene

GeneHancer (GH) Regulatory Elements for IRGQ Gene

Promoters and enhancers for IRGQ Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043594 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.7 -0.2 -166 4.5 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D ZNF610 GLIS1 ZNF576 IRGQ SRRM5 ZNF45 ZNF180 ZNF112 ZNF283 ZNF224 ZNF225 MRPS15P2
GH19I043773 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39.1 -183.7 -183673 12.4 YBX1 ZNF416 ZNF143 ZNF263 SP3 ZFP41 MEF2D ZNF610 ZNF585B GLIS1 KCNN4 ZNF180 ZNF45 ZNF225 ZNF224 ZNF284 ZNF227 ZNF283 ZNF223 ZNF576
GH19I044111 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 36.3 -516.8 -516772 2.8 PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 ZNF225 LOC100379224 ZNF45 ZNF180 ZNF227 ZNF283 ZNF576 ZNF112 ZNF224 ZNF226
GH19I044259 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 39.9 -663.8 -663803 1.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B ZNF233 ZNF45 ZNF180 ZNF225 ZNF224 ZNF284 ZNF227 ZNF234 ZNF235 CLASRP
GH19I043618 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 21.1 -23.4 -23430 2.6 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 GLIS1 RCOR2 ZNF428 LOC105372411 GC19P043620 ZNF45 ZNF225 ZNF180 ZNF224 ZNF234 ZNF227 ZNF284
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IRGQ on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRGQ gene promoter:

Genomic Locations for IRGQ Gene

Genomic Locations for IRGQ Gene
chr19:43,584,367-43,596,229
(GRCh38/hg38)
Size:
11,863 bases
Orientation:
Minus strand
chr19:44,088,519-44,100,287
(GRCh37/hg19)

Genomic View for IRGQ Gene

Genes around IRGQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRGQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRGQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRGQ Gene

Proteins for IRGQ Gene

  • Protein details for IRGQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZA9-IRGQ_HUMAN
    Recommended name:
    Immunity-related GTPase family Q protein
    Protein Accession:
    Q8WZA9
    Secondary Accessions:
    • B2RNP3

    Protein attributes for IRGQ Gene

    Size:
    623 amino acids
    Molecular mass:
    62717 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRGQ Gene

Post-translational modifications for IRGQ Gene

No Post-translational modifications

Other Protein References for IRGQ Gene

No data available for DME Specific Peptides for IRGQ Gene

Domains & Families for IRGQ Gene

Gene Families for IRGQ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IRGQ Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IRGQ Gene

Graphical View of Domain Structure for InterPro Entry

Q8WZA9

UniProtKB/Swiss-Prot:

IRGQ_HUMAN :
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
genes like me logo Genes that share domains with IRGQ: view

Function for IRGQ Gene

Phenotypes From GWAS Catalog for IRGQ Gene

Gene Ontology (GO) - Molecular Function for IRGQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with IRGQ: view

Phenotypes for IRGQ Gene

genes like me logo Genes that share phenotypes with IRGQ: view

miRNA for IRGQ Gene

miRTarBase miRNAs that target IRGQ

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRGQ Gene

Localization for IRGQ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRGQ gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IRGQ Gene

Pathways & Interactions for IRGQ Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRGQ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IRGQ Gene

Drugs & Compounds for IRGQ Gene

No Compound Related Data Available

Transcripts for IRGQ Gene

Unigene Clusters for IRGQ Gene

Immunity-related GTPase family, Q:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRGQ Gene

No ASD Table

Relevant External Links for IRGQ Gene

GeneLoc Exon Structure for
IRGQ
ECgene alternative splicing isoforms for
IRGQ

Expression for IRGQ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRGQ Gene

Protein differential expression in normal tissues from HIPED for IRGQ Gene

This gene is overexpressed in Fetal Brain (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IRGQ Gene



Protein tissue co-expression partners for IRGQ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRGQ Gene:

IRGQ

SOURCE GeneReport for Unigene cluster for IRGQ Gene:

Hs.6217

Evidence on tissue expression from TISSUES for IRGQ Gene

  • Nervous system(4.7)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with IRGQ: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRGQ Gene

Orthologs for IRGQ Gene

This gene was present in the common ancestor of mammals.

Orthologs for IRGQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRGQ 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia IRGQ 33 34
  • 83.28 (n)
cow
(Bos Taurus)
Mammalia IRGQ 33 34
  • 82.31 (n)
mouse
(Mus musculus)
Mammalia Irgq 33 16 34
  • 79.61 (n)
rat
(Rattus norvegicus)
Mammalia Irgq 33
  • 79.32 (n)
Species where no ortholog for IRGQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IRGQ Gene

ENSEMBL:
Gene Tree for IRGQ (if available)
TreeFam:
Gene Tree for IRGQ (if available)

Paralogs for IRGQ Gene

No data available for Paralogs for IRGQ Gene

Variants for IRGQ Gene

Sequence variations from dbSNP and Humsavar for IRGQ Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193920821 uncertain-significance, Malignant tumor of prostate 43,592,103(-) C/T coding_sequence_variant, missense_variant
rs1000006746 -- 43,584,563(-) G/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000301047 -- 43,596,524(-) T/G upstream_transcript_variant
rs1000781750 -- 43,590,421(-) C/A 3_prime_UTR_variant
rs1000828208 -- 43,589,166(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IRGQ Gene

Variant ID Type Subtype PubMed ID
dgv3603n100 CNV gain 25217958
nsv833839 CNV loss 17160897

Variation tolerance for IRGQ Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 25.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRGQ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IRGQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRGQ Gene

Disorders for IRGQ Gene

Additional Disease Information for IRGQ

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IRGQ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IRGQ Gene

Publications for IRGQ Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  2. The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage. (PMID: 16277747) Bekpen C … Howard JC (Genome biology 2005) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for IRGQ Gene

Sources for IRGQ Gene

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