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IRGM Gene

protein-coding   GIFtS: 53
GCID: GC05P150208

Immunity-Related GTPase Family, M

(Previous names: immunity-related GTPase family, M1)
(Previous symbol: IRGM1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Immunity-Related GTPase Family, M1 2     LPS-Stimulated RAW 264.7 Macrophage Protein 47 Homolog2 3
IRGM11 2 3     Immunity-Related GTPase Family M Protein2
IFI12 3 5     LRG-47-Like Protein2
LRG472 3 5     EC 3.6.5.-3
Immunity-Related GTPase Family, M11 2     Immunity-Related GTPase Family M Protein 13
Interferon-Inducible Protein 12 3     IBD195
LRG-472 3     

External Ids:    HGNC: 295971   Entrez Gene: 3456112   Ensembl: ENSG000002376937   OMIM: 6082125   UniProtKB: A1A4Y43   

Export aliases for IRGM gene to outside databases

Previous GC identifer: GC05P145371


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRGM Gene:
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the
innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms
that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and
tuberculosis.(provided by RefSeq, Oct 2010)

GeneCards Summary for IRGM Gene:
IRGM (immunity-related GTPase family, M) is a protein-coding gene. Diseases associated with IRGM include mycobacterium tuberculosis, protection against, and crohn's disease. GO annotations related to this gene include hydrolase activity, acting on acid anhydrides and GTP binding. An important paralog of this gene is IRGC.

UniProtKB/Swiss-Prot: IRGM_HUMAN, A1A4Y4
Function: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions
in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine
production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By
similarity)

Gene Wiki entry for IRGM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRGM gene promoter:
         STAT1   SREBP-1c   STAT1beta   NF-kappaB   STAT1alpha   SREBP-1b   SREBP-1a   POU2F1   POU2F1a   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for IRGM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRGM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.1   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q33.1

IRGM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRGM gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P150208:  view genomic region     (about GC identifiers)

Start:
150,226,085 bp from pter      End:
150,280,298 bp from pter
Size:
54,214 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: IRGM_HUMAN, A1A4Y4 (See protein sequence)
Recommended Name: Immunity-related GTPase family M protein  
Size: 181 amino acids; 20142 Da
Miscellaneous: Depletion of IRGM by siRNA favors mycobacteria survival in macrophages
Miscellaneous: There is a huge difference in terms of sequence and regulation of expression compared to the mouse
ortholog and hence, the function might be slightly different (PubMed:16277747)
Sequence caution: Sequence=AAI28169.1; Type=Erroneous initiation; Sequence=EAW61704.1; Type=Erroneous initiation;
Secondary accessions: B3VEX0

Explore the universe of human proteins at neXtProt for IRGM: NX_A1A4Y4

Explore proteomics data for IRGM at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRGM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001139277.1  
    ENSEMBL proteins: 
     ENSP00000428220   ENSP00000429819  

    IRGM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for IRGM
    OriGene Custom MassSpec
    OriGene Custom Protein Services for IRGM
    GenScript Custom Purified and Recombinant Proteins Services for IRGM
    Novus Biologicals IRGM Proteins
    Novus Biologicals IRGM Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for IRGM
    Cloud-Clone Corp. Proteins for IRGM

    IRGM Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of IRGM
    Browse R&D Systems for Antibodies
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    Novus Biologicals IRGM Antibodies
    Abcam antibodies for IRGM
    Cloud-Clone Corp. Antibodies for IRGM
    ThermoFisher Antibodies for IRGM
    LSBio Antibodies in human, mouse, rat for IRGM

    IRGM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for IRGM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for IRGM
    Cloud-Clone Corp. CLIAs for IRGM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007743 Interferon-induced_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry A1A4Y4

    ProtoNet protein and cluster: A1A4Y4

    UniProtKB/Swiss-Prot: IRGM_HUMAN, A1A4Y4
    Similarity: Belongs to the interferon-inducible GTPase family


    IRGM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRGM_HUMAN, A1A4Y4
    Function: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions
    in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine
    production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By
    similarity)
    Induction: Not up-regulated by IFNG/IFN-gamma

         Enzyme Number (IUBMB): EC 3.6.5.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
    GO:0016817hydrolase activity, acting on acid anhydrides IEA--
         
    IRGM for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irgm1):
     homeostasis/metabolism  immune system 

    IRGM for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irgm1tm1Gat for IRGM

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRGM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRGM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRGM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRGM

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IRGM

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for IRGM
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    GenScript: all cDNA clones in your preferred vector: IRGM (NM_001145805)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRGM

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRGM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRGM_HUMAN, A1A4Y4: Golgi apparatus membrane (By similarity). Cell membrane (By similarity). Cytoplasmic
    vesicle, phagosome membrane (By similarity). Cytoplasmic vesicle, autophagosome membrane (By similarity). Cell
    projection, phagocytic cup (By similarity). Note=Behaves like an integral membrane protein (By similarity).
    Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing
    autophagosomes (By similarity). Preferentially associated with cis- and medial-Golgi (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    golgi apparatus2
    lysosome2
    nucleus2
    plasma membrane2
    vacuole2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0000421autophagic vacuole membrane IEA--
    GO:0001891phagocytic cup IEA--
    GO:0016020membrane ----
    GO:0030670phagocytic vesicle membrane IEA--

    IRGM for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRGM About    
    See pathways by source

    SuperPathContained pathways About
    1Leishmaniasis
    Toxoplasmosis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for IRGM):
        Toxoplasmosis


    IRGM for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRGM: 
              Interferons & Receptors in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for IRGM

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0006954inflammatory response IEA--
    GO:0045087innate immune response IEA--

    IRGM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRGM



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for IRGM gene: 
    NM_001145805.1  

    Unigene Clusters for IRGM:

    Immunity-related GTPase family, M
    Hs.519680 , Hs.652148  [show with all ESTs]
    Unigene Representative Sequences: BC038539, EU742619
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522154(uc010jhk.3) ENST00000609660 ENST00000520549
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IRGM
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRGM (NM_001145805)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRGM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRGM
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IRGM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRGM
      QuantiTect SYBR Green Assays in human, mouse, rat IRGM
      QuantiFast Probe-based Assays in human, mouse, rat IRGM

    Additional mRNA sequence: 

    BC128167.1 BC128168.1 EU742619.1 

    1 DOTS entry:

    DT.95179447 

    2 AceView cDNA sequences:

    BC038539 BI764111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRGM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACCTCAGCA
    IRGM Expression
    About this image


    IRGM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
    IRGM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRGM Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.519680 Hs.652148

    UniProtKB/Swiss-Prot: IRGM_HUMAN, A1A4Y4
    Tissue specificity: Widely expressed (at protein level). Expressed in several tissues including colon, small bowel
    and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRGM: 
              Interferons & Receptors in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Autophagy in human mouse rat
              Cell Death PathwayFinder in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRGM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IRGM gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irgm15
    Irgm21
    immunity-related GTPase family M member 15
    immunity-related GTPase family M member 21
    68.74(n)1
    54.8(a)1
      11 (28.84 cM)5
    543961  NM_019440.31  NP_062313.31 
     488619685 
    lizard
    (Anolis carolinensis)
    Reptilia IRGM6
    immunity-related GTPase family, M
    12(a)
    1 ↔ 1
    AAWZ02039903(2023-7670)
    zebrafish
    (Danio rerio)
    Actinopterygii irgq16
    CT027800.16
    (see all 4)
    Uncharacterized protein
    (see all 4)
    9(a)
    5(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    16(28045681-28050935) ENSDARG00000086847
    16(47593699-47598247) ENSDARG00000089112


    ENSEMBL Gene Tree for IRGM (if available)
    TreeFam Gene Tree for IRGM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRGM gene
    IRGC2  
    1 SIMAP similar gene for IRGM using alignment to 3 protein entries:     IRGM_HUMAN (see all proteins):
    IRGC

    IRGM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRGM (see all 172)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596214021,2
    C--150224706(+) GTGAG-/TGAG  
            
    AGTGT
    1 -- us2k10--------
    rs796657551,2
    C,F--150225055(+) GGCTGC/TGGGCG 1 -- us2k13Minor allele frequency- T:0.10CSA NA EA 242
    rs573299401,2
    C,F--150225082(+) ACGAGT/ATCCGG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1119119171,2
    C,F--150225087(+) TTCCGG/AGTGGG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1126494241,2
    F--150225111(+) GGCCCG/ACGCTC 1 -- us2k13Minor allele frequency- A:0.09CSA WA 122
    rs77223931,2
    C--150226071(+) ctgccC/Tgaacc 1 -- us2k10--------
    rs339935641,2
    C--150226253(+) CCGGGG/-AGAAA 1 -- ut511Minor allele frequency- -:0.50CSA 2
    rs1166708161,2
    C,F--150500224(+) GCTCTC/TGCCAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1882134421,2
    --150500234(+) TATGGC/TGGGTT 1 -- us2k10--------
    rs1471413871,2
    C--150500261(+) ACAAGC/TGAGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IRGM (150226085 - 150280298 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for IRGM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883032CNV Loss21882294
    nsv428129CNV Loss18775914
    nsv5067CNV Loss18451855
    dgv1863e1CNV Complex17122850
    dgv1862e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): IRGM
    Locus Specific Mutation Databases (LSDB): IRGM

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRGM
    DNA2.0 Custom Variant and Variant Library Synthesis for IRGM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608212   
    OMIM disorders: 607948  612278  
    UniProtKB/Swiss-Prot: IRGM_HUMAN, A1A4Y4
  • Inflammatory bowel disease 19 (IBD19) [MIM:612278]: A chronic, relapsing inflammation of the
    gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis
    phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most
    frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may
    contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the
    inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not
    observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • 16 diseases for IRGM:    
    About MalaCards
    mycobacterium tuberculosis, protection against    crohn's disease    inflammatory bowel disease 19    tuberculosis, protection against
    tuberculosis    toxoplasmosis    ankylosing spondylitis    spondylitis
    celiac disease    ulcerative colitis    pulmonary tuberculosis    inflammatory bowel disease
    systemic lupus erythematosus    lupus erythematosus    multiple myeloma    myeloma

    3 diseases from the University of Copenhagen DISEASES database for IRGM:
    Crohn's disease     Ulcerative colitis     Tuberculosis

    IRGM for disorders           About GeneDecksing

    Genetic Association Database (GAD): IRGM
    Human Genome Epidemiology (HuGE) Navigator: IRGM (25 documents)

    Export disorders for IRGM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRGM gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with IRGM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. (PubMed id 19174780)1, 2, 4 Weersma R.K.... Vermeire S. (Am. J. Gastroenterol. 2009)
    2. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. (PubMed id 17554261)1, 2, 4 Parkes M.... Mathew C.G. (Nat. Genet. 2007)
    3. Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. (PubMed id 19750224)1, 4, 9 Intemann C.D....Meyer C.G. (PLoS Pathog. 2009)
    4. A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PubMed id 20962850)1, 4 Budarf M.L....Rioux J.D. (Genes Immun. 2011)
    5. Identification of a novel IRGM promoter single nucleotide polymorphism associated with tuberculosis. (PubMed id 20547146)1, 4 Che N....Li C. ( international journal of clinical chemistry 2010)
    6. Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease. (PubMed id 20106866)1, 4 Prescott N.J....Mathew C.G. (Hum. Mol. Genet. 2010)
    7. Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas? (PubMed id 20395867)1, 4 Wolfkamp S.C....Stokkers P.C. (amp 2010)
    8. Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease. (PubMed id 20024904)1, 4 Latiano A....Annese V. (Inflamm. Bowel Dis. 2010)
    9. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. (PubMed id 20360734)1, 4  ....Donnelly P. (Nature 2010)
    10. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. (PubMed id 21102463)1, 4 Franke A....Parkes M. (Nat. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 345611 HGNC: 29597 AceView: LRG47 Ensembl:ENSG00000237693 euGenes: HUgn345611
    ECgene: IRGM Kegg: 345611 H-InvDB: IRGM

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRGM Pharmacogenomics, SNPs, Pathways

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