Aliases for IRGM Gene
External Ids for IRGM Gene
Previous HGNC Symbols for IRGM Gene
Previous GeneCards Identifiers for IRGM Gene
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
GeneCards Summary for IRGM Gene
IRGM (Immunity Related GTPase M) is a Protein Coding gene. Diseases associated with IRGM include Inflammatory Bowel Disease 19 and Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included. Among its related pathways are Toxoplasmosis. GO annotations related to this gene include GTP binding and hydrolase activity, acting on acid anhydrides. An important paralog of this gene is IRGC.
UniProtKB/Swiss-Prot for IRGM Gene
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).