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Aliases for IRGC Gene

Aliases for IRGC Gene

  • Immunity Related GTPase Cinema 2 3 5
  • Immunity-Related GTPase Family, Cinema 1 2 3
  • Immunity-Related GTPase Cinema 1 3 4
  • Iigp5 3 4
  • IRGC1 3 4
  • Interferon-Gamma-Inducible GTPase IFGGE Protein 3
  • Interferon-Inducible GTPase 5 3
  • EC 3.6.5.- 4
  • R30953_1 3
  • EC 3.6.5 61
  • CINEMA 3
  • IFGGE 3

External Ids for IRGC Gene

Previous HGNC Symbols for IRGC Gene

  • IRGC1

Previous GeneCards Identifiers for IRGC Gene

  • GC19P048915
  • GC19P044220
  • GC19P040652

Summaries for IRGC Gene

GeneCards Summary for IRGC Gene

IRGC (Immunity Related GTPase Cinema) is a Protein Coding gene. Diseases associated with IRGC include Solar Retinopathy and Echolalia. GO annotations related to this gene include GTP binding and hydrolase activity, acting on acid anhydrides. An important paralog of this gene is IRGM.

Gene Wiki entry for IRGC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRGC Gene

Genomics for IRGC Gene

Regulatory Elements for IRGC Gene

Enhancers for IRGC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F043773 1.8 FANTOM5 Ensembl ENCODE 11 +63.7 63676 12.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZNF302 ZNF45 ZNF180 ZNF225 ZNF284 ZNF224 ZNF234 KCNN4 XRCC1 ZNF223 LOC100505715
GH19F043744 1.4 FANTOM5 Ensembl ENCODE 12.2 +29.1 29105 1.6 HDGF CTCF ZNF792 WRNIP1 RAD21 ZNF791 SCRT2 ZNF169 ZNF547 SMC3 SMG9 PLAUR KCNN4 ZNF45 ZNF224 ZNF180 ZNF234 ZNF155 IRGC ZNF284
GH19F043667 1.1 ENCODE 10.6 -46.7 -46741 4.2 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 ZNF2 ZNF416 ZNF143 FOS ZNF45 ZNF180 ZNF234 ZNF155 ZNF224 ZNF225 ZNF284 XRCC1 ZNF223 MRPS15P2
GH19F043798 1 ENCODE 11.4 +83.0 83008 1.6 ZNF133 ZNF2 ZNF121 GLIS2 ZNF416 KLF7 ZNF548 ZNF263 SP3 YY2 ZNF45 ZNF180 ZNF234 ZNF224 ZNF284 ZNF225 LYPD5 ZNF230 XRCC1 ENSG00000268601
GH19F043663 1 Ensembl ENCODE 11 -51.7 -51666 1.3 ZNF362 ZNF274 ZNF157 ZNF747 ZNF169 PATZ1 EED IKZF1 ZNF600 ZNF280C ZNF45 ZNF180 ZNF155 ZNF225 CADM4 IRGC LOC100505715 ZNF234 GC19P043667 RN7SL368P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around IRGC on UCSC Golden Path with GeneCards custom track

Genomic Location for IRGC Gene

43,716,010 bp from pter
43,720,036 bp from pter
4,027 bases
Plus strand

Genomic View for IRGC Gene

Genes around IRGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRGC Gene

Proteins for IRGC Gene

  • Protein details for IRGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-inducible GTPase 5
    Protein Accession:
    Secondary Accessions:
    • Q05BR8

    Protein attributes for IRGC Gene

    463 amino acids
    Molecular mass:
    50288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRGC Gene

Selected DME Specific Peptides for IRGC Gene


Post-translational modifications for IRGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRGC Gene

Domains & Families for IRGC Gene

Protein Domains for IRGC Gene

Suggested Antigen Peptide Sequences for IRGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
genes like me logo Genes that share domains with IRGC: view

No data available for Gene Families for IRGC Gene

Function for IRGC Gene

Molecular function for IRGC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.

Enzyme Numbers (IUBMB) for IRGC Gene

Gene Ontology (GO) - Molecular Function for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA --
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with IRGC: view
genes like me logo Genes that share phenotypes with IRGC: view

Animal Model Products

miRNA for IRGC Gene

miRTarBase miRNAs that target IRGC

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRGC Gene

Localization for IRGC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRGC gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IRGC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRGC Gene

Pathways & Interactions for IRGC Gene

No Data Available

Interacting Proteins for IRGC Gene

Selected Interacting proteins: Q6NXR0-IIGP5_HUMAN for IRGC Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for IRGC Gene


No data available for Pathways by source and SIGNOR curated interactions for IRGC Gene

Drugs & Compounds for IRGC Gene

(5) Drugs for IRGC Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Guanosine diphosphate Experimental Pharma Target 0
2-(N-Morpholino)-Ethanesulfonic Acid Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with IRGC: view

Transcripts for IRGC Gene

mRNA/cDNA for IRGC Gene

Unigene Clusters for IRGC Gene

Immunity-related GTPase family, cinema:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRGC Gene

No ASD Table

Relevant External Links for IRGC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRGC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IRGC Gene

mRNA differential expression in normal tissues according to GTEx for IRGC Gene

This gene is overexpressed in Testis (x52.0).

Protein differential expression in normal tissues from HIPED for IRGC Gene

This gene is overexpressed in Testis (49.0) and Ovary (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRGC Gene

Protein tissue co-expression partners for IRGC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IRGC Gene:


SOURCE GeneReport for Unigene cluster for IRGC Gene:

genes like me logo Genes that share expression patterns with IRGC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRGC Gene

Orthologs for IRGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRGC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRGC 34 35
  • 99.71 (n)
(Canis familiaris)
Mammalia LOC476445 34
  • 88.55 (n)
  • 52 (a)
(Bos Taurus)
Mammalia IRGC 34 35
  • 86.44 (n)
(Rattus norvegicus)
Mammalia Irgc 34
  • 85.86 (n)
(Mus musculus)
Mammalia Irgc1 34 16 35
  • 85.54 (n)
(Ornithorhynchus anatinus)
Mammalia IRGC 35
  • 43 (a)
(Monodelphis domestica)
Mammalia IRGC 35
  • 42 (a)
(Anolis carolinensis)
Reptilia IRGC 35
  • 39 (a)
(Danio rerio)
Actinopterygii IRGC (2 of 7) 35
  • 40 (a)
irgf1 35
  • 40 (a)
irge4 35
  • 35 (a)
irgf2 35
  • 35 (a)
IRGC (1 of 7) 35
  • 34 (a)
IRGC (3 of 7) 35
  • 25 (a)
IRGC (6 of 7) 35
  • 21 (a)
Species where no ortholog for IRGC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRGC Gene

Gene Tree for IRGC (if available)
Gene Tree for IRGC (if available)

Paralogs for IRGC Gene

Paralogs for IRGC Gene

(2) SIMAP similar genes for IRGC Gene using alignment to 2 proteins: Pseudogenes for IRGC Gene

genes like me logo Genes that share paralogs with IRGC: view

Variants for IRGC Gene

Sequence variations from dbSNP and Humsavar for IRGC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1074204 -- 43,716,311(-) GCCCT(C/T)TCCCT intron-variant
rs111429395 -- 43,718,065(+) TGTCT(-/CAAA/CAAACAAA)CAAAC intron-variant
rs111455046 -- 43,718,405(+) TCCAG(A/G)GCGAC intron-variant, utr-variant-5-prime
rs111487205 -- 43,714,951(+) TCTCT(C/T)CTTAG upstream-variant-2KB
rs111682405 -- 43,715,099(+) GAGGG(A/G)AGACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IRGC Gene

Variant ID Type Subtype PubMed ID
esv3644475 CNV loss 21293372
nsv2503 CNV insertion 18451855
nsv833839 CNV loss 17160897

Variation tolerance for IRGC Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRGC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRGC Gene

Disorders for IRGC Gene

MalaCards: The human disease database

(8) MalaCards diseases for IRGC Gene - From: DISEASES

Disorder Aliases PubMed IDs
solar retinopathy
  • solar retinitis
  • accommodative strain
factitious disorder
  • munchausen syndrome
multiple personality disorder
  • dissociative identity disorder
- elite association - COSMIC cancer census association via MalaCards
Search IRGC in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRGC

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRGC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRGC Gene

Publications for IRGC Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for IRGC Gene

Sources for IRGC Gene

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