IRGC Gene
protein-coding GIFtS: 46
GCID: GC19P044220
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immunity-related GTPase family, cinema(Previous names: immunity-related GTPase family, cinema 1 )
(Previous symbol: IRGC1)
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Aliases
for IRGC gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Immunity-Related GTPase Family, Cinema1 2 | | R30953_12 | | IRGC11 2 3 | | Interferon Inducible GTPase 52 | | CINEMA1 2 | | Interferon-Gamma-Inducible GTPase IFGGE Protein2 | | Iigp51 2 | | Interferon-Inducible GTPase 52 | | Immunity-Related GTPase Family, Cinema 11 2 | | EC 3.6.5.-3 | | Immunity-Related GTPase Cinema 12 3 | | IIGP53 | | IFGGE2 | | EC 3.6.58 |
Export aliases for IRGC gene to outside databasesPrevious GC identifers: GC19P048915 GC19P040652 |
Summaries
for IRGC gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for IRGC (Interferon-inducible GTPase 5)
|
Genomic Views
for IRGC gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRGC gene promoter:
Pax-5 AP-2gamma MZF-1 Max c-Rel AP-2beta AP-2alpha Pax-4a AP-2alphaA c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRGC
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRGC |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.32IRGC Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P044220: view genomic region
(about GC identifiers)
Start:
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44,220,162 bp from pter |
End:
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44,224,173 bp from pter |
Size:
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4,012 bases |
Orientation:
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plus strand |
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Proteins
for IRGC gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IIGP5_HUMAN, Q6NXR0 (See
protein sequence)Recommended Name: Interferon-inducible GTPase 5 Size: 463 amino acids; 50288 Da
Secondary accessions: Q05BR8Explore the universe of human proteins at neXtProt for IRGC: NX_Q6NXR0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NXR0
4 DME Specific Peptides for IRGC (Q6NXR0)
IRGC Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_062558.1
ENSEMBL proteins: ENSP00000244314
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016020 | membrane |
-- | -- | | GO:0020005 | symbiont-containing vacuole membrane |
IEA | -- |
IRGC for ontologies About GeneDecksing
IRGC Antibody Products:
Assay Products for IRGC: |
Protein
Domains /
Families
for IRGC gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IRGC for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NXR0ProtoNet protein and cluster: Q6NXR0 UniProtKB/Swiss-Prot: IIGP5_HUMAN, Q6NXR0Similarity: Belongs to the interferon-inducible GTPase family |
Function
for IRGC gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IIGP5_HUMAN, Q6NXR0Catalytic activity: GTP + H(2)O = GDP + phosphateEnzyme Numbers (IUBMB): EC 3.6.52 EC 3.6.5.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRGC (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRGC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: IRGC (NM_019612) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRGC | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRGC |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRGC |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
IRGC for ontologies About GeneDecksing
|
Pathways & Interactions
for IRGC gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRGC
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010506 | regulation of autophagy |
IEA | -- | | GO:0035458 | cellular response to interferon-beta |
IEA | -- | | GO:0042832 | defense response to protozoan |
IEA | -- | | GO:0050829 | defense response to Gram-negative bacterium |
IEA | -- |
IRGC for ontologies About GeneDecksing
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Drugs & Compounds
for IRGC gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for IRGC
1 HMDB Compound for IRGC About this table
2 DrugBank Compounds for IRGC About this table
Search CenterWatch for drugs/clinical trials and news about IRGC / IIGP5
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Transcripts
for IRGC gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRGC gene: NM_019612.3 Unigene Cluster for IRGC: Immunity-related GTPase family, cinema Hs.515444 [show with all ESTs]Unigene Representative Sequence: NM_0196121 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000244314(uc002oxh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRGC (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRGC
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: IRGC (NM_019612) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRGC | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRGC |
Additional cDNA sequence: BC033853.1 BC066939.1 1 DOTS entry: DT.110227 24/64 AceView cDNA sequences (see all 64): BX103486 BI828552 BE044229 BI520533 AW873559 BE044235 AI283570 BC066939 BE503483 BI825481 AI122717 BE041516 BC033853 BI828548 NM_019612 AI125548 BG722126 BI520032 BI520261 BI826126 BI826173 BX359457 AW593346 BI828394
GeneLoc Exon Structure
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Expression
for IRGC gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRGC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCAGGGCT
About this image
See IRGC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRGC
SOURCE GeneReport for Unigene cluster: Hs.515444
SABiosciences Custom PCR Arrays for IRGC
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRGC
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRGC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRGC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRGC | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRGC |
Orthologs
for IRGC gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IRGC gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
IRGC6IRGC6 |
-- |
39(a)38(a) |
1 ↔ many1 ↔ many |
LGf(879953-882426) AAWZ02038480(6071-9599) |
ENSEMBL Gene Tree for IRGC (if available)
TreeFam Gene Tree for IRGC (if available) |
Paralogs
for IRGC gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IRGC gene
- IRGM2
1 SIMAP similar gene for IRGC using alignment to 2 protein entries: IIGP5_HUMAN (see all proteins):IFGGE
IRGC for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IRGC
PGOHUM00000234713
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Genomic Variants
for IRGC gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRGC (44220162 - 44224173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for IRGC: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRGC |
|
Disorders
/ Diseases
for IRGC gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRGC for disorders About GeneDecksing
3  diseases for IRGC: About MalaCardssolar retinopathy hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: IRGC (1 document)
Export disorders for IRGC gene to outside databases
|
Publications
for IRGC gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRGC gene integrated from 9 sources:
(articles sorted by number of sources associating them with IRGC) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
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External Searches for IRGC gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing IRGC gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IRGC gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IRGC gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for IRGC | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for IRGC gene:
Search GeneIP for patents involving IRGC
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IRGC gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for IRGC | | OriGene shRNA RFP for IRGC | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRGC | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRGC | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IRGC | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRGC | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRGC | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IRGC | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IRGC | | OriGene Custom Protein Services for IRGC | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRGC | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRGC | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRGC | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRGC | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRGC | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRGC |
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| | | | Search Tocris compounds for IRGC |
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 | | | IRGC Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRGC |
|  |  |  | | | | ThermoFisher Antibodies for IRGC |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRGC |
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