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Aliases for IRGC Gene

Aliases for IRGC Gene

  • Immunity-Related GTPase Family, Cinema 2 3
  • Immunity-Related GTPase Family, Cinema 1 2 3
  • Immunity-Related GTPase Cinema 1 3 4
  • Iigp5 3 4
  • IRGC1 3 4
  • Interferon-Gamma-Inducible GTPase IFGGE Protein 3
  • Interferon Inducible GTPase 5 3
  • Interferon-Inducible GTPase 5 3
  • EC 3.6.5.- 4
  • R30953_1 3
  • EC 3.6.5 63
  • CINEMA 3
  • IFGGE 3

External Ids for IRGC Gene

Previous HGNC Symbols for IRGC Gene

  • IRGC1

Previous GeneCards Identifiers for IRGC Gene

  • GC19P048915
  • GC19P044220
  • GC19P040652

Summaries for IRGC Gene

GeneCards Summary for IRGC Gene

IRGC (Immunity-Related GTPase Family, Cinema) is a Protein Coding gene. GO annotations related to this gene include GTP binding and hydrolase activity, acting on acid anhydrides. An important paralog of this gene is IRGM.

Gene Wiki entry for IRGC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRGC Gene

Genomics for IRGC Gene

Regulatory Elements for IRGC Gene

Genomic Location for IRGC Gene

Start:
43,716,010 bp from pter
End:
43,720,021 bp from pter
Size:
4,012 bases
Orientation:
Plus strand

Genomic View for IRGC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRGC Gene

Proteins for IRGC Gene

  • Protein details for IRGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXR0-IIGP5_HUMAN
    Recommended name:
    Interferon-inducible GTPase 5
    Protein Accession:
    Q6NXR0
    Secondary Accessions:
    • Q05BR8

    Protein attributes for IRGC Gene

    Size:
    463 amino acids
    Molecular mass:
    50288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRGC Gene

Proteomics data for IRGC Gene at MOPED

Selected DME Specific Peptides for IRGC Gene

Post-translational modifications for IRGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRGC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for IRGC Gene

Protein Domains for IRGC Gene

Suggested Antigen Peptide Sequences for IRGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NXR0

UniProtKB/Swiss-Prot:

IIGP5_HUMAN :
  • Q6NXR0
Domain:
  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
genes like me logo Genes that share domains with IRGC: view

No data available for Gene Families for IRGC Gene

Function for IRGC Gene

Molecular function for IRGC Gene

UniProtKB/Swiss-Prot CatalyticActivity: GTP + H(2)O = GDP + phosphate

Enzyme Numbers (IUBMB) for IRGC Gene

Gene Ontology (GO) - Molecular Function for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0016817 hydrolase activity, acting on acid anhydrides --
genes like me logo Genes that share ontologies with IRGC: view

miRNA for IRGC Gene

miRTarBase miRNAs that target IRGC

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for IRGC Gene

Localization for IRGC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRGC Gene COMPARTMENTS Subcellular localization image for IRGC gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
extracellular 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IRGC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for IRGC Gene

Pathways for IRGC Gene

SuperPathways for IRGC Gene

No Data Available

Interacting Proteins for IRGC Gene

Gene Ontology (GO) - Biological Process for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with IRGC: view

No data available for Pathways by source for IRGC Gene

Compounds for IRGC Gene

(1) HMDB Compounds for IRGC Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Drugbank Compounds for IRGC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(N-Morpholino)-Ethanesulfonic Acid
target
Guanosine-5'-Diphosphate
146-91-8 target
genes like me logo Genes that share compounds with IRGC: view

Transcripts for IRGC Gene

mRNA/cDNA for IRGC Gene

Unigene Clusters for IRGC Gene

Immunity-related GTPase family, cinema:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRGC Gene

No ASD Table

Relevant External Links for IRGC Gene

GeneLoc Exon Structure for
IRGC
ECgene alternative splicing isoforms for
IRGC

Expression for IRGC Gene

mRNA expression in normal human tissues for IRGC Gene

mRNA differential expression in normal tissues according to GTEx for IRGC Gene

This gene is overexpressed in Testis (52.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IRGC Gene

SOURCE GeneReport for Unigene cluster for IRGC Gene Hs.515444

genes like me logo Genes that share expressions with IRGC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRGC Gene

Orthologs for IRGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRGC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRGC 35
  • 99.71 (n)
  • 100 (a)
IRGC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRGC 35
  • 86.44 (n)
  • 88.74 (a)
IRGC 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRGC 36
  • 52 (a)
OneToOne
LOC476445 35
  • 88.55 (n)
  • 92.01 (a)
mouse
(Mus musculus)
Mammalia Irgc1 35
  • 85.54 (n)
  • 90.24 (a)
Irgc1 16
Irgc1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRGC 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRGC 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irgc 35
  • 85.86 (n)
  • 90.26 (a)
lizard
(Anolis carolinensis)
Reptilia IRGC 36
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii IRGC (1 of 7) 36
  • 34 (a)
OneToMany
IRGC (2 of 7) 36
  • 40 (a)
OneToMany
IRGC (3 of 7) 36
  • 25 (a)
OneToMany
IRGC (6 of 7) 36
  • 21 (a)
OneToMany
irge4 36
  • 35 (a)
OneToMany
irgf1 36
  • 40 (a)
OneToMany
irgf2 36
  • 35 (a)
OneToMany
Species with no ortholog for IRGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRGC Gene

ENSEMBL:
Gene Tree for IRGC (if available)
TreeFam:
Gene Tree for IRGC (if available)

Paralogs for IRGC Gene

Paralogs for IRGC Gene

Selected SIMAP similar genes for IRGC Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for IRGC Gene

genes like me logo Genes that share paralogs with IRGC: view

Variants for IRGC Gene

Sequence variations from dbSNP and Humsavar for IRGC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs180790 -- 43,714,344(+) cgcgg(G/T)ggcag upstream-variant-2KB
rs182953 -- 43,714,207(+) cacgg(G/T)ggctc upstream-variant-2KB
rs346048 -- 43,720,009(+) CAAAT(A/T)ACCAA utr-variant-3-prime
rs346049 -- 43,718,973(+) TCCTG(C/T)TGGTC reference, synonymous-codon
rs346050 -- 43,715,598(+) ACCAC(A/G)TTGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IRGC Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
nsv2503 CNV Insertion 18451855

Relevant External Links for IRGC Gene

HapMap Linkage Disequilibrium report
IRGC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRGC Gene

Disorders for IRGC Gene

Relevant External Links for IRGC

Human Genome Epidemiology (HuGE) Navigator
IRGC
genes like me logo Genes that share disorders with IRGC: view

No data available for UniProtKB/Swiss-Prot for IRGC Gene

Publications for IRGC Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for IRGC Gene

Sources for IRGC Gene

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