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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRGC Gene

protein-coding   GIFtS: 47
GCID: GC19P044220

Immunity-Related GTPase Family, Cinema

(Previous names: immunity-related GTPase family, cinema 1)
(Previous symbol: IRGC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Immunity-Related GTPase Family, Cinema1 2     R30953_12
IRGC11 2 3     Interferon Inducible GTPase 52
Immunity-Related GTPase Family, Cinema 11 2     Interferon-Gamma-Inducible GTPase IFGGE Protein2
Immunity-Related GTPase Cinema 12 3     Interferon-Inducible GTPase 52
CINEMA2     EC 3.6.5.-3
IFGGE2     IIGP53
Iigp52     EC 3.6.58

External Ids:    HGNC: 288351   Entrez Gene: 562692   Ensembl: ENSG000001244497   UniProtKB: Q6NXR03   

Export aliases for IRGC gene to outside databases

Previous GC identifers: GC19P048915 GC19P040652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for IRGC Gene: 
IRGC (immunity-related GTPase family, cinema) is a protein-coding gene. Diseases associated with IRGC include solar retinopathy, and hepatitis b. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is IRGM.

Gene Wiki entry for IRGC (Interferon-inducible GTPase 5) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRGC gene promoter:
         Pax-5   AP-2gamma   MZF-1   Max   c-Rel   AP-2beta   AP-2alpha   Pax-4a   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidIRGC promoter sequence
   Search SABiosciences Chromatin IP Primers for IRGC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRGC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.32

IRGC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRGC gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P044220:  view genomic region     (about GC identifiers)

Start:
44,220,162 bp from pter      End:
44,224,173 bp from pter
Size:
4,012 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IIGP5_HUMAN, Q6NXR0 (See protein sequence)
Recommended Name: Interferon-inducible GTPase 5  
Size: 463 amino acids; 50288 Da
Secondary accessions: Q05BR8

Explore the universe of human proteins at neXtProt for IRGC: NX_Q6NXR0

Explore proteomics data for IRGC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NXR0

  • 4 DME Specific Peptides for IRGC (Q6NXR0)
     FYFVRTKVD  LEALRTAFESGD  MLQEQVLKTALV  GVIQALPVPGLAAAYDDALLI 

    IRGC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRGC Protein Expression
    REFSEQ proteins: NP_062558.1  
    ENSEMBL proteins: 
     ENSP00000244314   ENSP00000471425  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IEA--

    IRGC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR007743 Interferon-induced_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry Q6NXR0

    ProtoNet protein and cluster: Q6NXR0

    UniProtKB/Swiss-Prot: IIGP5_HUMAN, Q6NXR0
    Similarity: Belongs to the interferon-inducible GTPase family


    IRGC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IIGP5_HUMAN, Q6NXR0
    Catalytic activity: GTP + H(2)O = GDP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.52 EC 3.6.5.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
    GO:0016817hydrolase activity, acting on acid anhydrides IEA--
         
    IRGC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRGC 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRGC 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for IRGC

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRGC (IIGP5)

    1 HMDB Compound for IRGC    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 DrugBank Compounds for IRGC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(N-Morpholino)-Ethanesulfonic Acid-- --target--10592235
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    Search CenterWatch for drugs/clinical trials and news about IRGC / IIGP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for IRGC gene: 
    NM_019612.3  

    Unigene Cluster for IRGC:

    Immunity-related GTPase family, cinema
    Hs.515444  [show with all ESTs]
    Unigene Representative Sequence: NM_019612
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244314(uc002oxh.3) ENST00000596627
    miRNA
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    hsa-miR-1262
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    Inhib. RNA
    Products:
         
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    Clone
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    OriGene ORF clones in mouse, rat for IRGC
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                         Customized lentivirus expression plasmids for stable overexpression of IRGC 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for IRGC
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRGC

    Additional mRNA sequence: 

    BC033853.1 BC066939.1 

    1 DOTS entry:

    DT.110227 

    24/64 AceView cDNA sequences (see all 64):

    BC066939 NM_019612 BE503483 BX103486 BI825481 BC033853 AI125548 AW873559 
    BE041516 AI283570 AI122717 BE044229 BE044235 BI828548 BI520533 BI828552 
    BG722800 BF115492 BG723426 BI520032 AA335595 BI826173 BI520261 BI826126 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRGC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCAGGGCT
    IRGC Expression
    About this image


    See IRGC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRGC

    SOURCE GeneReport for Unigene cluster: Hs.515444
        SABiosciences Custom PCR Arrays for IRGC
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRGC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRGC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IRGC gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irgc11 , 5 immunity-related GTPase family, cinema 11, 5 85.54(n)1
    90.24(a)1
      7 (10.74 cM)5
    2101451  NM_199013.21  NP_950178.21 
     244319225 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 6)
    --
    43(a)
    38(a)
    (see all 6)
    possible ortholog
    possible ortholog
    (see all 6)
    AAWZ02038481(2177-3918)
    AAWZ02038480(6089-9943)
    zebrafish
    (Danio rerio)
    Actinopterygii CT027800.16
    CR391937.26
    (see all 3)
    Uncharacterized protein
    (see all 3)
    7(a)
    4(a)
    (see all 3)
    1 ↔ 1
    possible ortholog
    (see all 3)
    16(47593699-47598247)
    16(28045853-28050928)


    ENSEMBL Gene Tree for IRGC (if available)
    TreeFam Gene Tree for IRGC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRGC gene
    IRGM2  
    2 SIMAP similar genes for IRGC using alignment to 2 protein entries:     IIGP5_HUMAN (see all proteins):
    IFGGE    IRGM

    IRGC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for IRGC
    PGOHUM00000234713


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/217 SNPs in IRGC are shown (see all 217)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1920315481,2
    --44218217(+) GATCAC/TGGCTC 1 -- us2k10--------
    rs1844980911,2
    --44218367(+) CTCACA/GCCTGT 1 -- us2k10--------
    rs1454612451,2
    C--44218719(+) ACCTCA/GGCCTC 1 -- us2k10--------
    rs1411561741,2
    C--44218887(+) TGCTCA/GGTGTC 1 -- us2k10--------
    rs175600941,2
    C,F,H--44218921(+) GTTCAC/ATCTCT 1 -- us2k117Minor allele frequency- A:0.04NA NS EA 2122
    rs1892814221,2
    --44218971(+) TGAGTC/TGTGTG 1 -- us2k10--------
    rs3768961711,2
    C--44219030(+) TATGCA/GGCCAA 1 -- us2k10--------
    rs1136693991,2
    C--44219106(+) CTCCTC/TAGTTG 1 -- us2k11Minor allele frequency- T:0.00CSA 1
    rs680986541,2
    C--44219107(+) CCTTA-/CTCGTTGT 1 -- cds10--------
    rs1451155281,2
    --44219121(+) CAGAGC/GCTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for IRGC (44220162 - 44224173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IRGC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv2503CNV Insertion18451855
    nsv833839CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for IRGC:    About MalaCards
    solar retinopathy    hepatitis b    hepatitis


    IRGC for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: IRGC (1 document)

    Export disorders for IRGC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRGC gene integrated from 9 sources:
    (articles sorted by number of sources associating them with IRGC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    2. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    3. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56269 HGNC: 28835 AceView: R30953_1 Ensembl:ENSG00000124449 euGenes: HUgn56269
    ECgene: IRGC H-InvDB: IRGC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRGC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRGC gene:
    Search GeneIP for patents involving IRGC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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