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Aliases for IRGC Gene

Aliases for IRGC Gene

  • Immunity Related GTPase Cinema 2 3
  • Immunity-Related GTPase Family, Cinema 1 2 3
  • Immunity-Related GTPase Cinema 1 3 4
  • Iigp5 3 4
  • IRGC1 3 4
  • Interferon-Gamma-Inducible GTPase IFGGE Protein 3
  • Immunity-Related GTPase Family, Cinema 5
  • Interferon Inducible GTPase 5 3
  • EC 3.6.5.- 4
  • R30953_1 3
  • EC 3.6.5 63
  • CINEMA 3
  • IFGGE 3

External Ids for IRGC Gene

Previous HGNC Symbols for IRGC Gene

  • IRGC1

Previous GeneCards Identifiers for IRGC Gene

  • GC19P048915
  • GC19P044220
  • GC19P040652

Summaries for IRGC Gene

GeneCards Summary for IRGC Gene

IRGC (Immunity Related GTPase Cinema) is a Protein Coding gene. Diseases associated with IRGC include Solar Retinopathy and Factitious Disorder. GO annotations related to this gene include GTP binding and hydrolase activity, acting on acid anhydrides. An important paralog of this gene is IRGM.

Gene Wiki entry for IRGC Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRGC Gene

Genomics for IRGC Gene

Regulatory Elements for IRGC Gene

Enhancers for IRGC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IRGC on UCSC Golden Path with GeneCards custom track

Genomic Location for IRGC Gene

43,716,010 bp from pter
43,720,036 bp from pter
4,027 bases
Plus strand

Genomic View for IRGC Gene

Genes around IRGC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRGC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRGC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRGC Gene

Proteins for IRGC Gene

  • Protein details for IRGC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Interferon-inducible GTPase 5
    Protein Accession:
    Secondary Accessions:
    • Q05BR8

    Protein attributes for IRGC Gene

    463 amino acids
    Molecular mass:
    50288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRGC Gene

Proteomics data for IRGC Gene at MOPED

Selected DME Specific Peptides for IRGC Gene

Post-translational modifications for IRGC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRGC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for IRGC Gene

Protein Domains for IRGC Gene

Suggested Antigen Peptide Sequences for IRGC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
  • Contains 1 IRG-type G (guanine nucleotide-binding) domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
genes like me logo Genes that share domains with IRGC: view

No data available for Gene Families for IRGC Gene

Function for IRGC Gene

Molecular function for IRGC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
GTP + H(2)O = GDP + phosphate.

Enzyme Numbers (IUBMB) for IRGC Gene

Gene Ontology (GO) - Molecular Function for IRGC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with IRGC: view
genes like me logo Genes that share phenotypes with IRGC: view

Animal Model Products

miRNA for IRGC Gene

miRTarBase miRNAs that target IRGC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IRGC Gene

Localization for IRGC Gene

Subcellular locations from

Jensen Localization Image for IRGC Gene COMPARTMENTS Subcellular localization image for IRGC gene
Compartment Confidence
chloroplast 2
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for IRGC Gene

Pathways & Interactions for IRGC Gene

SuperPathways for IRGC Gene

No Data Available

Interacting Proteins for IRGC Gene

Gene Ontology (GO) - Biological Process for IRGC Gene


No data available for Pathways by source and SIGNOR curated interactions for IRGC Gene

Drugs & Compounds for IRGC Gene

(3) Drugs for IRGC Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
2-(N-Morpholino)-Ethanesulfonic Acid Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for IRGC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with IRGC: view

Transcripts for IRGC Gene

mRNA/cDNA for IRGC Gene

Unigene Clusters for IRGC Gene

Immunity-related GTPase family, cinema:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRGC Gene

No ASD Table

Relevant External Links for IRGC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRGC Gene

mRNA expression in normal human tissues for IRGC Gene

mRNA differential expression in normal tissues according to GTEx for IRGC Gene

This gene is overexpressed in Testis (x52.0).

Protein differential expression in normal tissues from HIPED for IRGC Gene

This gene is overexpressed in Testis (49.0) and Ovary (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IRGC Gene

SOURCE GeneReport for Unigene cluster for IRGC Gene Hs.515444

genes like me logo Genes that share expression patterns with IRGC: view

Protein tissue co-expression partners for IRGC Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for IRGC Gene

Orthologs for IRGC Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRGC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia IRGC 35
  • 86.44 (n)
  • 88.74 (a)
  • 88 (a)
(Canis familiaris)
Mammalia LOC476445 35
  • 88.55 (n)
  • 92.01 (a)
  • 52 (a)
(Mus musculus)
Mammalia Irgc1 35
  • 85.54 (n)
  • 90.24 (a)
Irgc1 16
Irgc1 36
  • 89 (a)
(Pan troglodytes)
Mammalia IRGC 35
  • 99.71 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Irgc 35
  • 85.86 (n)
  • 90.26 (a)
(Monodelphis domestica)
Mammalia IRGC 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia IRGC 36
  • 43 (a)
(Anolis carolinensis)
Reptilia IRGC 36
  • 39 (a)
(Danio rerio)
Actinopterygii IRGC (1 of 7) 36
  • 34 (a)
IRGC (2 of 7) 36
  • 40 (a)
IRGC (3 of 7) 36
  • 25 (a)
IRGC (6 of 7) 36
  • 21 (a)
irge4 36
  • 35 (a)
irgf1 36
  • 40 (a)
irgf2 36
  • 35 (a)
Species with no ortholog for IRGC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRGC Gene

Gene Tree for IRGC (if available)
Gene Tree for IRGC (if available)

Paralogs for IRGC Gene

Paralogs for IRGC Gene

(2) SIMAP similar genes for IRGC Gene using alignment to 2 proteins: Pseudogenes for IRGC Gene

genes like me logo Genes that share paralogs with IRGC: view

Variants for IRGC Gene

Sequence variations from dbSNP and Humsavar for IRGC Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11555891 - 43,718,961(+) GCTAT(A/G)ACTTC reference, missense
rs8104645 -- 43,717,113(+) TGCCA(C/T)GGCAG intron-variant
rs68098654 -- 43,714,955(+) CCTTA(-/CTC)GTTGT upstream-variant-2KB
rs17560094 -- 43,714,769(+) GTTCA(A/C)TCTCT upstream-variant-2KB
rs71169282 -- 43,714,179(+) TTTTT(-/TTT)AAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for IRGC Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV Loss 17160897
nsv2503 CNV Insertion 18451855

Variation tolerance for IRGC Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for IRGC Gene

Disorders for IRGC Gene

MalaCards: The human disease database

(8) MalaCards diseases for IRGC Gene - From: DISEASES

Disorder Aliases PubMed IDs
solar retinopathy
  • solar retinitis
factitious disorder
  • munchausen syndrome
multiple personality disorder
  • dissociative identity disorder
chorioretinal scar
- elite association - COSMIC cancer census association via MalaCards
Search IRGC in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRGC

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with IRGC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRGC Gene

Publications for IRGC Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  4. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25

Products for IRGC Gene

Sources for IRGC Gene