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Aliases for IRG1 Gene

Aliases for IRG1 Gene

  • Immunoresponsive 1 Homolog (Mouse) 2 3
  • Cis-Aconitic Acid Decarboxylase 3 4
  • Aconitate Decarboxylase 3 4
  • CAD 3 4
  • Immune-Responsive Gene 1 Protein Homolog 3
  • Immune-Responsive Gene 1 Protein 4
  • Cis-Aconitate Decarboxylase 3
  • EC 4.1.1.6 4

External Ids for IRG1 Gene

Previous GeneCards Identifiers for IRG1 Gene

  • GC13P076411
  • GC13P077511

Summaries for IRG1 Gene

GeneCards Summary for IRG1 Gene

IRG1 (Immunoresponsive 1 Homolog (Mouse)) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Metabolism. GO annotations related to this gene include 2-methylcitrate dehydratase activity and aconitate decarboxylase activity.

UniProtKB/Swiss-Prot for IRG1 Gene

  • Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRG1 Gene

Genomics for IRG1 Gene

Regulatory Elements for IRG1 Gene

Genomic Location for IRG1 Gene

Start:
76,948,497 bp from pter
End:
76,958,642 bp from pter
Size:
10,146 bases
Orientation:
Plus strand

Genomic View for IRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRG1 Gene

Proteins for IRG1 Gene

  • Protein details for IRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NK06-IRG1_HUMAN
    Recommended name:
    Cis-aconitate decarboxylase
    Protein Accession:
    A6NK06
    Secondary Accessions:

    Protein attributes for IRG1 Gene

    Size:
    481 amino acids
    Molecular mass:
    52628 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRG1 Gene

Proteomics data for IRG1 Gene at MOPED

Post-translational modifications for IRG1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRG1 Gene

Domains for IRG1 Gene

Protein Domains for IRG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IRG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NK06

UniProtKB/Swiss-Prot:

IRG1_HUMAN :
  • A6NK06
Family:
  • Belongs to the PrpD family.
genes like me logo Genes that share domains with IRG1: view

No data available for Gene Families for IRG1 Gene

Function for IRG1 Gene

Molecular function for IRG1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Cis-aconitate = itaconate + CO(2).
UniProtKB/Swiss-Prot Function: Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.
UniProtKB/Swiss-Prot Induction: Up-regulated after lipopolysaccharide (LPS) stimulation. Up-regulated in LPS-tolerized macrophage by LPS. Up-regulated in peripheral blood mononuclear cells (PBMC) of patient after acute sepsis.

Enzyme Numbers (IUBMB) for IRG1 Gene

Gene Ontology (GO) - Molecular Function for IRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047547 2-methylcitrate dehydratase activity IEA --
GO:0047613 aconitate decarboxylase activity IDA 23610393
genes like me logo Genes that share ontologies with IRG1: view

Animal Model Products

CRISPR Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for IRG1 Gene

Localization for IRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRG1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRG1 Gene COMPARTMENTS Subcellular localization image for IRG1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with IRG1: view

Pathways for IRG1 Gene

genes like me logo Genes that share pathways with IRG1: view

Interacting Proteins for IRG1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366682%0d%0a9606.ENSP00000257570%0d%0a9606.ENSP00000368699%0d%0a
Selected Interacting proteins: ENSP00000366682 for IRG1 Gene via STRING

Gene Ontology (GO) - Biological Process for IRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002760 positive regulation of antimicrobial humoral response IDA 23610393
GO:0006952 defense response IDA 23610393
GO:0006954 inflammatory response IEA --
GO:0007566 embryo implantation ISS --
GO:0008152 metabolic process IDA 23610393
genes like me logo Genes that share ontologies with IRG1: view

Transcripts for IRG1 Gene

mRNA/cDNA for IRG1 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRG1 Gene

Immunoresponsive 1 homolog (mouse):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRG1 Gene

No ASD Table

Relevant External Links for IRG1 Gene

GeneLoc Exon Structure for
IRG1
ECgene alternative splicing isoforms for
IRG1

Expression for IRG1 Gene

mRNA expression in normal human tissues for IRG1 Gene

mRNA differential expression in normal tissues according to GTEx for IRG1 Gene

This gene is overexpressed in Colon - Transverse (9.4), Lung (6.6), Whole Blood (6.0), and Stomach (5.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for IRG1 Gene

SOURCE GeneReport for Unigene cluster for IRG1 Gene Hs.160789

mRNA Expression by UniProt/SwissProt for IRG1 Gene

A6NK06-IRG1_HUMAN
Tissue specificity: Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells.
genes like me logo Genes that share expressions with IRG1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IRG1 Gene

Orthologs for IRG1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRG1 35
  • 98.8 (n)
  • 97.68 (a)
IRG1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRG1 36
  • 82 (a)
OneToOne
LOC504806 35
  • 85.25 (n)
  • 81.68 (a)
dog
(Canis familiaris)
Mammalia IRG1 35
  • 84.37 (n)
  • 83.54 (a)
IRG1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irg1 35
  • 83.23 (n)
  • 84.01 (a)
Irg1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRG1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRG1 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irg1 35
  • 83.87 (n)
  • 84.22 (a)
chicken
(Gallus gallus)
Aves IRG1 35
  • 66.67 (n)
  • 66.67 (a)
IRG1 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRG1 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia irg1 35
  • 65.09 (n)
  • 66.59 (a)
zebrafish
(Danio rerio)
Actinopterygii irg1 35
  • 59.29 (n)
  • 59.51 (a)
irg1 36
  • 56 (a)
OneToOne
Species with no ortholog for IRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRG1 Gene

ENSEMBL:
Gene Tree for IRG1 (if available)
TreeFam:
Gene Tree for IRG1 (if available)

Paralogs for IRG1 Gene

No data available for Paralogs for IRG1 Gene

Variants for IRG1 Gene

Sequence variations from dbSNP and Humsavar for IRG1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs588702 -- 76,948,790(+) TGAAT(C/T)ATGAC intron-variant
rs611161 -- 76,953,656(+) CTCCC(G/T)CCCAC reference, synonymous-codon
rs640192 -- 76,955,509(+) GGCCA(A/G)TGACA reference, missense
rs645504 -- 76,958,887(+) attta(C/T)aaagg downstream-variant-500B
rs647712 -- 76,952,781(+) TTTCC(C/T)ATGTT intron-variant

Relevant External Links for IRG1 Gene

HapMap Linkage Disequilibrium report
IRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IRG1 Gene

Disorders for IRG1 Gene

Relevant External Links for IRG1

Genetic Association Database (GAD)
IRG1
genes like me logo Genes that share disorders with IRG1: view

No data available for UniProtKB/Swiss-Prot for IRG1 Gene

Publications for IRG1 Gene

  1. Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production. (PMID: 23610393) Michelucci A. … Hiller K. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3 4
  2. Progesterone regulation of the mammalian ortholog of methylcitrate dehydratase (immune response gene 1) in the uterine epithelium during implantation through the protein kinase C pathway. (PMID: 12893884) Chen B. … Pollard J.W. (Mol. Endocrinol. 2003) 2 3
  3. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through ROS. (PMID: 23609450) Li Y. … Cao X. (J. Biol. Chem. 2013) 3 4
  4. Expression profile of human immune-responsive gene 1 and generation and characterization of polyclonal antiserum. (PMID: 21424586) Xiao W. … He Y. (Mol. Cell. Biochem. 2011) 3
  5. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4

Products for IRG1 Gene

Sources for IRG1 Gene

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