Aliases for IRG1 Gene
External Ids for IRG1 Gene
GeneCards Summary for IRG1 Gene
IRG1 (Immunoresponsive 1 Homolog (Mouse)) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Metabolism. GO annotations related to this gene include 2-methylcitrate dehydratase activity and aconitate decarboxylase activity.
UniProtKB/Swiss-Prot for IRG1 Gene
Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; IRG1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation.