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IRF9 Gene

protein-coding   GIFtS: 60
GCID: GC14P024630

Interferon Regulatory Factor 9

(Previous names: interferon-stimulated transcription factor 3, gamma (48kD),...)
(Previous symbol: ISGF3G)
  See IRF9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Regulatory Factor 91 2     IRF-92 3
ISGF3G1 2 3 5     IFN-Alpha-Responsive Transcription Factor Subunit2 3
Interferon-Stimulated Transcription Factor 3, Gamma (48kD)1 2     ISGF-3 Gamma2 3
Interferon-Stimulated Transcription Factor 3, Gamma 48kDa1 2     ISGF3 P48 Subunit2 3
Interferon-Stimulated Gene Factor 3 Gamma2 3     ISGF32 5
Transcriptional Regulator ISGF3 Subunit Gamma2 3     p482

External Ids:    HGNC: 61311   Entrez Gene: 103792   Ensembl: ENSG000002139287   OMIM: 1475745   UniProtKB: Q009783   

Export aliases for IRF9 gene to outside databases

Previous GC identifers: GC14P023702 GC14P023690 GC14P004745


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for IRF9 Gene:
IRF9 (interferon regulatory factor 9) is a protein-coding gene. Diseases associated with IRF9 include ebola hemorrhagic fever, and lymphocytic choriomeningitis. GO annotations related to this gene include regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is IRF8.

UniProtKB/Swiss-Prot: IRF9_HUMAN, Q00978
Function: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I
IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine
phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a
complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response
element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral
state

Gene Wiki entry for IRF9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRF9 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IRF9 promoter sequence
   Search Chromatin IP Primers for IRF9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

IRF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024630:  view genomic region     (about GC identifiers)

Start:
24,630,262 bp from pter      End:
24,635,774 bp from pter
Size:
5,513 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IRF9_HUMAN, Q00978 (See protein sequence)
Recommended Name: Interferon regulatory factor 9  
Size: 393 amino acids; 43696 Da
Subunit: Interacts with STAT2 in the cytoplasm. Forms the interferon-stimulated gene factor 3 complex (ISGF3) with
the heterodimer STAT1:STAT2; upon stimulation
Secondary accessions: D3DS61

Explore the universe of human proteins at neXtProt for IRF9: NX_Q00978

Explore proteomics data for IRF9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See IRF9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006075.3  
    ENSEMBL proteins: 
     ENSP00000380073   ENSP00000453534   ENSP00000453974   ENSP00000453540   ENSP00000454095  
     ENSP00000454078   ENSP00000313529  
    Reactome Protein details: Q00978

    IRF9 Human Recombinant Protein Products:

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    OriGene Purified Protein for IRF9
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    GenScript Custom Purified and Recombinant Proteins Services for IRF9
    Novus Biologicals IRF9 Protein
    Novus Biologicals IRF9 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRF9

     
    Search eBioscience for Proteins for IRF9 

     
    antibodies-online proteins for IRF9 (2 products) 

     
    antibodies-online peptides for IRF9

    IRF9 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for IRF9
    antibodies-online antibodies for IRF9 (40 products) 

    IRF9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IRF9
    Cloud-Clone Corp. CLIAs for IRF9
    Search eBioscience for ELISAs for IRF9 
    antibodies-online kits for IRF9 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR008984 SMAD_FHA_domain
     IPR019817 Interferon_reg_fac_CS
     IPR019471 Interferon_reg_factor-3
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q00978

    ProtoNet protein and cluster: Q00978

    1 Blocks protein domain: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF9_HUMAN, Q00978
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    Find genes that share domains with IRF9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRF9_HUMAN, Q00978
    Function: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I
    IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine
    phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a
    complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response
    element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral
    state
    Induction: By IFN-alpha and IFNB1/IFN-beta

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI17923090
         
    Find genes that share ontologies with IRF9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for IRF9:
     Synthetic lethal with c-Myc af 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Irf9):
     immune system  integument  skeleton 

    Find genes that share phenotypes with IRF9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Irf9tm1Ttg for IRF9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for IRF9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for IRF9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRF9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRF9

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRF9:
    hsa-mir-106b-5p (MIRT020418)

    Block miRNA regulation of human, mouse, rat IRF9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate IRF9 (see all 27):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-340 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidIRF9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for IRF9
    Predesigned siRNA for gene silencing in human, mouse, rat IRF9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for IRF9

    Clone
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    OriGene ORF clones in mouse, rat for IRF9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: IRF9 (NM_006084)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for IRF9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF9
    Addgene plasmids for IRF9 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for IRF9
    Browse ESI BIO Cell Lines and PureStem Progenitors for IRF9 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRF9_HUMAN, Q00978: Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS1630447
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with IRF9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRF9 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Immune response IFN alpha beta signaling pathway
    Immune response IFN alpha beta signaling pathway0.69
    Interferon alpha/beta signaling0.43
    2Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43
    3Jak-STAT signaling pathway
    Jak-STAT signaling pathway
    Type III interferon signaling0.00
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Influenza A
    Influenza A0.34
    Herpes simplex infection0.33
    Measles0.34


    Find genes that share SuperPaths with IRF9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for IRF9
        Interferon Pathway
    JAK-STAT Pathway

    2 GeneGo (Thomson Reuters) Pathways for IRF9
        Immune response IFN gamma signaling pathway
    Immune response IFN alpha/beta signaling pathway

    4 BioSystems Pathways for IRF9
        Type II interferon signaling (IFNG)
    Interferon type I
    Type III interferon signaling
    IFN-gamma pathway

    2 Reactome Pathways for IRF9
        Interferon alpha/beta signaling
    Interferon gamma signaling


    Selected Kegg Pathways  (Kegg details for IRF9) (see all 7):
        Osteoclast differentiation
    Jak-STAT signaling pathway
    Hepatitis C
    Measles
    Influenza A

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF9: 
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRF9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRF9 (Q009781, 2, 3 ENSP000003800734) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATN1P542592, 3, ENSP000003490764MINT-2873996 I2D: score=1 STRING: ENSP00000349076
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2874034 I2D: score=1 STRING: ENSP00000344782
    IFNA1P015623, ENSP000002769274I2D: score=1 STRING: ENSP00000276927
    STAT2P526301, 3, ENSP000003157684EBI-626526,EBI-1546963 I2D: score=6 STRING: ENSP00000315768
    IFNAR2P485511, 3, ENSP000003439574EBI-626526,EBI-958408 I2D: score=6 STRING: ENSP00000343957
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS1630447
    GO:0007166cell surface receptor signaling pathway TAS1630447
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0045351type I interferon biosynthetic process IEA--

    Find genes that share ontologies with IRF9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRF9

    8 Novoseek inferred chemical compound relationships for IRF9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    2',5'-oligoadenylate 70.5 3 9186002 (1), 8836915 (1), 10229853 (1)
    ifn-alpha 57.2 5 11106638 (4)
    tyrosine 53 17 1280824 (4), 9325014 (1), 12704120 (1), 19351818 (1) (see all 14)
    genistein 39.8 4 1280824 (1), 9325014 (1), 17559358 (1)
    retinoic acid 34.6 6 9186002 (3), 9669677 (1), 10435617 (1)
    cycloheximide 28.7 3 11882993 (1), 2118988 (1)
    adenine 7.14 5 1556141 (2), 2118988 (2)
    oligonucleotide 6.08 2 20038197 (1)



    Find genes that share compounds with IRF9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRF9 gene: 
    NM_006084.4  

    Unigene Cluster for IRF9:

    Interferon regulatory factor 9
    Hs.1706  [show with all ESTs]
    Unigene Representative Sequence: AK295467
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396864(uc010alj.3) ENST00000557894 ENST00000561342 ENST00000561009
    ENST00000560365 ENST00000561415 ENST00000559284 ENST00000560275 ENST00000561412
    ENST00000560852 ENST00000324076 ENST00000559863 ENST00000559229 ENST00000560542
    ENST00000560311
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate IRF9 (see all 27):
    hsa-miR-142-5p hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-302e hsa-miR-340 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidIRF9 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: IRF9 (NM_006084)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF9
    Addgene plasmids for IRF9 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for IRF9
    OriGene qSTAR qPCR primer pairs in human, mouse for IRF9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat IRF9
      QuantiTect SYBR Green Assays in human, mouse, rat IRF9
      QuantiFast Probe-based Assays in human, mouse, rat IRF9

    Additional mRNA sequence: 

    AK295467.1 AK308347.1 BC035716.2 M87503.1 U92994.1 

    15 DOTS entries:

    DT.312276  DT.87013010  DT.91987503  DT.120772566  DT.75161376  DT.100655274  DT.75106086  DT.87016063 
    DT.120772553  DT.100851623  DT.95236944  DT.99987526  DT.100655271  DT.100712018  DT.95236945 

    Selected AceView cDNA sequences (see all 410):

    CR610511 CR619285 AI872365 BM708088 CA305900 BU739671 BU633631 BQ695405 
    BM826910 AY256461 BX099826 BM450172 CB216083 BU195806 AK122711 BM905847 
    BF340236 CB126210 BC017376 BM782298 CD171831 BF530066 BM983142 AK055542 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRF9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCCAGCCA
    IRF9 Expression
    About this image

    IRF9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRF9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.1706
        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF9: 
              Type I Interferon Response in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for IRF9
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    QuantiFast Probe-based Assays in human, mouse, rat IRF9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IRF9 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf91 , 5 interferon regulatory factor 91, 5 77.81(n)1
    71.76(a)1
      14 (28.19 cM)5
    163911  NM_008394.31  NP_032420.11 
     556035715 
    chicken
    (Gallus gallus)
    Aves IRF106
    Gallus gallus interferon regulatory factor 10 (IRF...
    31(a)
    many ↔ many
    20(10405912-10410873)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    37(a)
    27(a)
    1 ↔ many
    1 ↔ many
    AAWZ02036190(21-15357)
    AAWZ02037623(734-6263)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004871581 interferon regulatory factor 8-like 49.16(n)
    41.11(a)
      100487158  XM_002939025.2  XP_002939071.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.123082 Danio rerio clone RK124A3H10 interferon-stimulated more 74.29(n)    AY398365.1 


    ENSEMBL Gene Tree for IRF9 (if available)
    TreeFam Gene Tree for IRF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRF9 gene
    IRF82  IRF22  IRF52  IRF32  IRF42  IRF12  IRF72  IRF62  
    7 SIMAP similar genes for IRF9 using alignment to 6 protein entries:     IRF9_HUMAN (see all proteins):
    IRF8    IRF4    IRF1    IRF3    IRF5    IRF2
    IRF7

    Find genes that share paralogs with IRF9           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for IRF9
    PGOHUM00000247509


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRF9 (see all 174)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143938491,2
    C,F--24630381(+) TGGCCG/ACCAGT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1881635261,2
    --24630723(+) CTCCCC/GAGACC 1 -- int10--------
    rs1923882251,2
    --24630828(+) CTGGCC/TCTGCC 1 -- int10--------
    rs1393179821,2
    --24630839(+) CACTTA/CTGCTG 1 -- int10--------
    rs1171334991,2
    C,F--24630986(+) ATGCTC/TGGGAA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs22363501,2
    C,F,O,H--24631010(-) TCCTGG/TTGACA 1 -- int122Minor allele frequency- T:0.22EA NA NS CSA 3935
    rs1499712181,2
    --24631076(+) TAAGAC/TCAGTG 1 -- int10--------
    rs1829964751,2
    --24631109(+) CACAGA/CTTAGA 1 -- int10--------
    rs1397629111,2
    C--24631142(+) GGGTT-/TTGTTGTT 1 -- int10--------
    rs1457209621,2
    C--24631142(+) GGGTT-/TTGTTG
            
    TTGTT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for IRF9 (24630262 - 24635774 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for IRF9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901498CNV Loss21882294
    nsv7249OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRF9
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 147574    OMIM disorders: --

    2 diseases for IRF9:    
    About MalaCards
    ebola hemorrhagic fever    lymphocytic choriomeningitis

    1 disease from the University of Copenhagen DISEASES database for IRF9:
    Ebola hemorrhagic fever

    Find genes that share disorders with IRF9           About GenesLikeMe

    9 Novoseek inferred disease relationships for IRF9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 31.8 2 8836915 (1), 11747630 (1)
    cervical carcinoma 21.6 2 17266037 (1)
    myeloid leukemia 19.2 2 9186002 (2)
    primary tumor 0.695 1 19715403 (1)
    tumors 0 6 15187113 (1), 19715403 (1), 15714000 (1), 11739693 (1) (see all 5)
    hepatitis b 0 1 10497156 (1)
    melanoma 0 1 9748142 (1)
    cancer 0 1 8289823 (1)
    tuberculosis 0 1 10925286 (1)

    Genetic Association Database (GAD): IRF9
    Human Genome Epidemiology (HuGE) Navigator: IRF9 (9 documents)

    Export disorders for IRF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRF9 gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with IRF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA- binding proteins. (PubMed id 1630447)1, 2, 3, 9 Veals S.A.... Levy D.E. (Mol. Cell. Biol. 1992)
    2. Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway. (PubMed id 20980339)1, 4 Huang H.H....Yu M.W. (Gut 2011)
    3. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (Pediatr. Pulmonol. 2010)
    5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    6. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (Pediatr. Infect. Dis. J. 2009)
    7. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. (PubMed id 19604093)1, 4 O'Doherty C....Vandenbroeck K. (Pharmacogenomics 2009)
    8. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (J. Infect. Dis. 2007)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation. (PubMed id 11846981)1, 2 Reich N.C. (J. Interferon Cytokine Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10379 HGNC: 6131 AceView: ISGF3GandRNF31 Ensembl:ENSG00000213928 euGenes: HUgn10379
    ECgene: IRF9 Kegg: 10379 H-InvDB: IRF9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for IRF9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for IRF9 gene:
    Search GeneIP for patents involving IRF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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