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Aliases for IRF9 Gene

Aliases for IRF9 Gene

  • Interferon Regulatory Factor 9 2 3
  • ISGF3G 3 4 6
  • Interferon-Stimulated Transcription Factor 3, Gamma (48kD) 2 3
  • Interferon-Stimulated Transcription Factor 3, Gamma 48kDa 2 3
  • IFN-Alpha-Responsive Transcription Factor Subunit 3 4
  • Transcriptional Regulator ISGF3 Subunit Gamma 3 4
  • Interferon-Stimulated Gene Factor 3 Gamma 3 4
  • ISGF3 P48 Subunit 3 4
  • ISGF-3 Gamma 3 4
  • ISGF3 3 6
  • IRF-9 3 4
  • P48 3

External Ids for IRF9 Gene

Previous Symbols for IRF9 Gene

  • ISGF3G

Summaries for IRF9 Gene

GeneCards Summary for IRF9 Gene

IRF9 (Interferon Regulatory Factor 9) is a Protein Coding gene. Diseases associated with IRF9 include ebola hemorrhagic fever and lymphocytic choriomeningitis. Among its related pathways are TGF-Beta Pathway and Interferon Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and regulatory region DNA binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF9 Gene

  • Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state

Gene Wiki entry for IRF9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF9 Gene

Genomics for IRF9 Gene

Genomic Location for IRF9 Gene

Start:
24,161,053 bp from pter
End:
24,166,565 bp from pter
Size:
5,513 bases
Orientation:
Plus strand

Genomic View for IRF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF9 Gene

Regulatory Elements for IRF9 Gene

Transcription factor binding sites by QIAGEN in the IRF9 gene promoter:

Proteins for IRF9 Gene

  • Protein details for IRF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00978-IRF9_HUMAN
    Recommended name:
    Interferon regulatory factor 9
    Protein Accession:
    Q00978
    Secondary Accessions:
    • D3DS61

    Protein attributes for IRF9 Gene

    Size:
    393 amino acids
    Molecular mass:
    43696 Da
    Quaternary structure:
    • Interacts with STAT2 in the cytoplasm. Forms the interferon-stimulated gene factor 3 complex (ISGF3) with the heterodimer STAT1:STAT2; upon stimulation

neXtProt entry for IRF9 Gene

Proteomics data for IRF9 Gene at MOPED

Post-translational modifications for IRF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF9 Gene

No data available for DME Specific Peptides for IRF9 Gene

Domains for IRF9 Gene

UniProtKB/Swiss-Prot:

IRF9_HUMAN
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.:
    • Q00978
Family:
  • Belongs to the IRF family.:
    • Q00978
genes like me logo Genes that share domains with IRF9: view

No data available for Gene Families for IRF9 Gene

Function for IRF9 Gene

Molecular function for IRF9 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
UniProtKB/Swiss-Prot Induction: By IFN-alpha and IFNB1/IFN-beta

Gene Ontology (GO) - Molecular Function for IRF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 17923090
genes like me logo Genes that share ontologies with IRF9: view

Phenotypes for IRF9 Gene

genes like me logo Genes that share phenotypes with IRF9: view

Animal Models for IRF9 Gene

MGI Knock Outs for IRF9:

miRNA for IRF9 Gene

miRTarBase miRNAs that target IRF9

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IRF9 Gene

Localization for IRF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF9 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF9 Gene COMPARTMENTS Subcellular localization image for IRF9 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for IRF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1630447
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF9: view

Pathways for IRF9 Gene

genes like me logo Genes that share pathways with IRF9: view

Gene Ontology (GO) - Biological Process for IRF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1630447
GO:0007166 cell surface receptor signaling pathway TAS 1630447
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045351 type I interferon biosynthetic process IEA --
genes like me logo Genes that share ontologies with IRF9: view

Compounds for IRF9 Gene

(8) Novoseek inferred chemical compound relationships for IRF9 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 70.5 3
ifn-alpha 57.2 4
tyrosine 53 17
genistein 39.8 3
retinoic acid 34.6 5
genes like me logo Genes that share compounds with IRF9: view

Transcripts for IRF9 Gene

Unigene Clusters for IRF9 Gene

Interferon regulatory factor 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRF9 Gene

No ASD Table

Relevant External Links for IRF9 Gene

GeneLoc Exon Structure for
IRF9
ECgene alternative splicing isoforms for
IRF9

Expression for IRF9 Gene

mRNA expression in normal human tissues for IRF9 Gene

mRNA differential expression in normal tissues according to GTEx for IRF9 Gene

This gene is overexpressed in Whole Blood (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRF9 Gene

SOURCE GeneReport for Unigene cluster for IRF9 Gene Hs.1706

genes like me logo Genes that share expressions with IRF9: view

Orthologs for IRF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF9 36
  • 99.15 (n)
  • 98.47 (a)
IRF9 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF9 36
  • 83.38 (n)
  • 77.61 (a)
ISGF3G 37
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF9 36
  • 83.84 (n)
  • 79.85 (a)
IRF9 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf9 36
  • 77.81 (n)
  • 71.76 (a)
Irf9 16
Irf9 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF9 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf9 36
  • 78.44 (n)
  • 72.99 (a)
chicken
(Gallus gallus)
Aves IRF10 37
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 37 (a)
OneToMany
-- 37
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487158 36
  • 49.16 (n)
  • 41.11 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12308 36
irf9 36
  • 52.66 (n)
  • 44.44 (a)
irf9 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for IRF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF9 Gene

ENSEMBL:
Gene Tree for IRF9 (if available)
TreeFam:
Gene Tree for IRF9 (if available)

Paralogs for IRF9 Gene

Paralogs for IRF9 Gene

Selected SIMAP similar genes for IRF9 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for IRF9 Gene

genes like me logo Genes that share paralogs with IRF9: view

Variants for IRF9 Gene

Sequence variations from dbSNP and Humsavar for IRF9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1042553 -- 24,166,393(+) TTTTT(A/T)ATTTT utr-variant-3-prime
rs1042556 -- 24,166,395(+) TTTWA(A/G/T)TTTGA utr-variant-3-prime
rs1042574 -- 24,166,518(+) TTCCT(C/T)TTAGA utr-variant-3-prime
rs1042576 -- 24,166,529(+) TATTC(A/C)CTAAG utr-variant-3-prime
rs2229258 -- 24,164,786(+) AGCCA(A/G)CTTGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for IRF9 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294
nsv7249 OTHER Inversion 18451855

Relevant External Links for IRF9 Gene

HapMap Linkage Disequilibrium report
IRF9
Human Gene Mutation Database (HGMD)
IRF9

Disorders for IRF9 Gene

(1) University of Copenhagen DISEASES for IRF9 Gene

(9) Novoseek inferred disease relationships for IRF9 Gene

Disease -log(P) Hits PubMed IDs
virus infection 31.8 2
cervical carcinoma 21.6 1
myeloid leukemia 19.2 2
primary tumor 0.695 1
tumors 0 5

Relevant External Links for IRF9

Genetic Association Database (GAD)
IRF9
Human Genome Epidemiology (HuGE) Navigator
IRF9
genes like me logo Genes that share disorders with IRF9: view

No data available for UniProtKB/Swiss-Prot for IRF9 Gene

Publications for IRF9 Gene

  1. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA- binding proteins. (PMID: 1630447) Veals S.A. … Levy D.E. (Mol. Cell. Biol. 1992) 2 3 4 23
  2. Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. (PMID: 8943351) Horvath C.M. … Darnell J.E. (Mol. Cell. Biol. 1996) 3 23
  3. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. (PMID: 10860992) Lau J.F. … Horvath C.M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23
  4. Role of metazoan mediator proteins in interferon-responsive transcription. (PMID: 12509459) Lau J.F. … Horvath C.M. (Mol. Cell. Biol. 2003) 3 23
  5. Functional relevance of the conserved DNA-binding domain of STAT2. (PMID: 15668228) Brierley M.M. … Fish E.N. (J. Biol. Chem. 2005) 3 23

Products for IRF9 Gene

  • Addgene plasmids for IRF9

Sources for IRF9 Gene

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