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Aliases for IRF9 Gene

Aliases for IRF9 Gene

  • Interferon Regulatory Factor 9 2 3
  • Interferon-Stimulated Transcription Factor 3, Gamma (48kD) 2 3
  • Interferon-Stimulated Transcription Factor 3, Gamma 48kDa 2 3
  • IFN-Alpha-Responsive Transcription Factor Subunit 3 4
  • Transcriptional Regulator ISGF3 Subunit Gamma 3 4
  • Interferon-Stimulated Gene Factor 3 Gamma 3 4
  • ISGF3 P48 Subunit 3 4
  • ISGF-3 Gamma 3 4
  • ISGF3G 3 4
  • IRF-9 3 4
  • ISGF3 3
  • P48 3

External Ids for IRF9 Gene

Previous HGNC Symbols for IRF9 Gene

  • ISGF3G

Previous GeneCards Identifiers for IRF9 Gene

  • GC14P023702
  • GC14P023690
  • GC14P024630
  • GC14P004745

Summaries for IRF9 Gene

GeneCards Summary for IRF9 Gene

IRF9 (Interferon Regulatory Factor 9) is a Protein Coding gene. Diseases associated with IRF9 include ebola hemorrhagic fever and lymphocytic choriomeningitis. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and regulatory region DNA binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF9 Gene

  • Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state

Gene Wiki entry for IRF9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF9 Gene

Genomics for IRF9 Gene

Regulatory Elements for IRF9 Gene

Transcription factor binding sites by QIAGEN in the IRF9 gene promoter:

Genomic Location for IRF9 Gene

Chromosome:
14
Start:
24,161,053 bp from pter
End:
24,166,565 bp from pter
Size:
5,513 bases
Orientation:
Plus strand

Genomic View for IRF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF9 Gene

Proteins for IRF9 Gene

  • Protein details for IRF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00978-IRF9_HUMAN
    Recommended name:
    Interferon regulatory factor 9
    Protein Accession:
    Q00978
    Secondary Accessions:
    • D3DS61

    Protein attributes for IRF9 Gene

    Size:
    393 amino acids
    Molecular mass:
    43696 Da
    Quaternary structure:
    • Interacts with STAT2 in the cytoplasm. Forms the interferon-stimulated gene factor 3 complex (ISGF3) with the heterodimer STAT1:STAT2; upon stimulation

neXtProt entry for IRF9 Gene

Proteomics data for IRF9 Gene at MOPED

Post-translational modifications for IRF9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRF9 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IRF9 (IRF9)

No data available for DME Specific Peptides for IRF9 Gene

Domains & Families for IRF9 Gene

Suggested Antigen Peptide Sequences for IRF9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00978

UniProtKB/Swiss-Prot:

IRF9_HUMAN :
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Belongs to the IRF family.
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Family:
  • Belongs to the IRF family.
genes like me logo Genes that share domains with IRF9: view

No data available for Gene Families for IRF9 Gene

Function for IRF9 Gene

Molecular function for IRF9 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state
UniProtKB/Swiss-Prot Induction:
By IFN-alpha and IFNB1/IFN-beta

Gene Ontology (GO) - Molecular Function for IRF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding --
GO:0001047 core promoter binding IMP 24882218
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 17923090
genes like me logo Genes that share ontologies with IRF9: view
genes like me logo Genes that share phenotypes with IRF9: view

Animal Models for IRF9 Gene

MGI Knock Outs for IRF9:

miRNA for IRF9 Gene

miRTarBase miRNAs that target IRF9

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRF9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IRF9 Gene

Localization for IRF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF9 Gene

Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF9 Gene COMPARTMENTS Subcellular localization image for IRF9 gene
Compartment Confidence
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for IRF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1630447
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF9: view

Pathways & Interactions for IRF9 Gene

genes like me logo Genes that share pathways with IRF9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for IRF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 1630447
GO:0007166 cell surface receptor signaling pathway TAS 1630447
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0045351 type I interferon biosynthetic process IEA --
genes like me logo Genes that share ontologies with IRF9: view

No data available for SIGNOR curated interactions for IRF9 Gene

Drugs & Compounds for IRF9 Gene

(3) Drugs for IRF9 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenine Approved Nutra 0
Genistein Investigational Pharma Activator AR agonist 51
tyrosine Nutra 547

(5) Additional Compounds for IRF9 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2,5-Oligoadenylate
Cycloheximide
ifn-alpha
Oligonucleotide
retinoic acid
302-79-4
genes like me logo Genes that share compounds with IRF9: view

Transcripts for IRF9 Gene

Unigene Clusters for IRF9 Gene

Interferon regulatory factor 9:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for IRF9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRF9 Gene

No ASD Table

Relevant External Links for IRF9 Gene

GeneLoc Exon Structure for
IRF9
ECgene alternative splicing isoforms for
IRF9

Expression for IRF9 Gene

mRNA expression in normal human tissues for IRF9 Gene

mRNA differential expression in normal tissues according to GTEx for IRF9 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for IRF9 Gene

This gene is overexpressed in Heart (20.7), Spleen (10.2), Lymph node (7.3), and Breast (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IRF9 Gene



SOURCE GeneReport for Unigene cluster for IRF9 Gene Hs.1706

genes like me logo Genes that share expression patterns with IRF9: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for IRF9 Gene

Orthologs for IRF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IRF9 35
  • 83.38 (n)
  • 77.61 (a)
ISGF3G 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF9 35
  • 83.84 (n)
  • 79.85 (a)
IRF9 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf9 35
  • 77.81 (n)
  • 71.76 (a)
Irf9 16
Irf9 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IRF9 35
  • 99.15 (n)
  • 98.47 (a)
IRF9 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf9 35
  • 78.44 (n)
  • 72.99 (a)
oppossum
(Monodelphis domestica)
Mammalia IRF9 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves IRF10 36
  • 31 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487158 35
  • 49.16 (n)
  • 41.11 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12308 35
irf9 35
  • 52.66 (n)
  • 44.44 (a)
irf9 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for IRF9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF9 Gene

ENSEMBL:
Gene Tree for IRF9 (if available)
TreeFam:
Gene Tree for IRF9 (if available)

Paralogs for IRF9 Gene

Paralogs for IRF9 Gene

(7) SIMAP similar genes for IRF9 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for IRF9 Gene

genes like me logo Genes that share paralogs with IRF9: view

Variants for IRF9 Gene

Sequence variations from dbSNP and Humsavar for IRF9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1042553 -- 24,166,393(+) TTTTT(A/T)ATTTT utr-variant-3-prime
rs1042556 -- 24,166,395(+) TTTWA(A/G/T)TTTGA utr-variant-3-prime
rs1042574 -- 24,166,518(+) TTCCT(C/T)TTAGA utr-variant-3-prime
rs1042576 -- 24,166,529(+) TATTC(A/C)CTAAG utr-variant-3-prime
rs2229258 -- 24,164,786(+) AGCCA(A/G)CTTGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for IRF9 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294
nsv7249 OTHER Inversion 18451855

Variation tolerance for IRF9 Gene

Residual Variation Intolerance Score: 26.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IRF9 Gene

HapMap Linkage Disequilibrium report
IRF9
Human Gene Mutation Database (HGMD)
IRF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRF9 Gene

Disorders for IRF9 Gene

MalaCards: The human disease database

(6) MalaCards diseases for IRF9 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ebola hemorrhagic fever
  • ebola virus disease
lymphocytic choriomeningitis
  • lymphocytic meningoencephalitis
skin papilloma
  • skin papilloma nos
boutonneuse fever
  • rickettsia conorii spotted fever
hepatitis c
  • hepatitis c infection
- elite association
Search IRF9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for IRF9

Genetic Association Database (GAD)
IRF9
Human Genome Epidemiology (HuGE) Navigator
IRF9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IRF9
genes like me logo Genes that share disorders with IRF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRF9 Gene

Publications for IRF9 Gene

  1. Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA- binding proteins. (PMID: 1630447) Veals S.A. … Levy D.E. (Mol. Cell. Biol. 1992) 2 23 67
  2. STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta. (PMID: 20038197) Rani M.R. … Ransohoff R.M. (J. Interferon Cytokine Res. 2010) 23 67
  3. Evaluation of an attenuated vesicular stomatitis virus vector expressing interferon-beta for use in malignant pleural mesothelioma: heterogeneity in interferon responsiveness defines potential efficacy. (PMID: 19715403) Saloura V. … Albelda S.M. (Hum. Gene Ther. 2010) 23 67
  4. [A novel molecular mechanism of interferon alpha-regulated expression of retinoic acid-induced gene G]. (PMID: 20403236) Lou Y.J. … Tong J.H. (Zhonghua Zhong Liu Za Zhi 2010) 23 67
  5. IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1. (PMID: 19351818) Lou Y.J. … Tong J.H. (Cancer Res. 2009) 23 67

Products for IRF9 Gene

Sources for IRF9 Gene

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