Aliases for IRF8 Gene
External Ids for IRF8 Gene
Previous HGNC Symbols for IRF8 Gene
Previous GeneCards Identifiers for IRF8 Gene
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
GeneCards Summary for IRF8 Gene
IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases associated with IRF8 include Immunodeficiency 32A, Mycobacteriosis, Autosomal Dominant and Immunodeficiency 32B, Monocyte And Dendritic Cell Deficiency, Autosomal Recessive. Among its related pathways are Type II interferon signaling (IFNG) and Interferon gamma signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and regulatory region DNA binding. An important paralog of this gene is IRF4.
UniProtKB/Swiss-Prot for IRF8 Gene
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5-TGAnTCA/GAAA-3), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).