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IRF7 Gene

protein-coding   GIFtS: 65
GCID: GC11M000602

Interferon Regulatory Factor 7

  See IRF7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Interferon Regulatory Factor 71 2     IRF7C2 5
IRF-72 3     IRF7H2 5
IRF7A2 5     IRF-7H2
IRF7B2 5     Interferon Regulatory Factor-7H2

External Ids:    HGNC: 61221   Entrez Gene: 36652   Ensembl: ENSG000001855077   OMIM: 6050475   UniProtKB: Q929853   

Export aliases for IRF7 gene to outside databases

Previous GC identifers: GC11P001127 GC11P001065 GC11P000583 GC11M000427


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for IRF7 Gene:
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF)
family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes,
including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue.
Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not
yet been established. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRF7 Gene:
IRF7 (interferon regulatory factor 7) is a protein-coding gene. Diseases associated with IRF7 include stomatitis, and central nervous system lymphoma. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is IRF8.

UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical
role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes
(IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element
(ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and
mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated,
MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more
critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells
and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes
phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and
nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG
genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either
directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may
play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and
regulate the anti-tumor properties of primary macrophages

Gene Wiki entry for IRF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NT_187586.1  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the IRF7 gene promoter:
         p300   STAT3   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IRF7 promoter sequence
   Search Chromatin IP Primers for IRF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat IRF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IRF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000602:  view genomic region     (about GC identifiers)

Start:
612,553 bp from pter      End:
615,999 bp from pter
Size:
3,447 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985 (See protein sequence)
Recommended Name: Interferon regulatory factor 7  
Size: 503 amino acids; 54278 Da
Subunit: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2.
Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7.
Interacts with Epstein-Barr virus LF2 and human herpes virus 8/HHV-8 proteins ORF45 and vIRF-1. Interacts with
MYD88 AND TRAF6
1 PDB 3D structure from and Proteopedia for IRF7:
2O61 (3D)    
Secondary accessions: B9EGL3 O00331 O00332 O00333 O75924 Q9UE79
Alternative splicing: 4 isoforms:  Q92985-1   Q92985-2   Q92985-3   Q92985-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IRF7: NX_Q92985

Explore proteomics data for IRF7 at MOPED

Post-translational modifications: 

  • Acetylation inhibits its DNA-binding ability and activity1
  • In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and
    subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway,
    phosphorylated by IRAK11
  • TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity)1
  • Sumoylated by TRIM28, which inhibits its transactivation activity1
  • Ubiquitination2 at Lys120, Lys341
  • Modification sites at PhosphoSitePlus

  • See IRF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001563.2  NP_004020.1  NP_004022.2  

    ENSEMBL proteins: 
     ENSP00000434009   ENSP00000331803   ENSP00000380704   ENSP00000433903   ENSP00000434607  
     ENSP00000329411   ENSP00000436696   ENSP00000432403   ENSP00000434524   ENSP00000380700  
     ENSP00000380697   ENSP00000380693  
    Reactome Protein details: Q92985

    IRF7 Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for IRF7
    Novus Biologicals IRF7 Proteins
    Novus Biologicals IRF7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for IRF7

     
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    antibodies-online proteins for IRF7 

     
    antibodies-online peptides for IRF7

    IRF7 Antibody Products:

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    antibodies-online antibodies for IRF7 (95 products) 

    IRF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for IRF7
    Cloud-Clone Corp. CLIAs for IRF7
    Search eBioscience for ELISAs for IRF7 
    antibodies-online kits for IRF7 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR008984 SMAD_FHA_domain
     IPR019817 Interferon_reg_fac_CS
     IPR019471 Interferon_reg_factor-3
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q92985

    ProtoNet protein and cluster: Q92985

    1 Blocks protein domain: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    Find genes that share domains with IRF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRF7_HUMAN, Q92985
    Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical
    role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes
    (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element
    (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and
    mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated,
    MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more
    critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells
    and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes
    phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and
    nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG
    genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either
    directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may
    play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and
    regulate the anti-tumor properties of primary macrophages
    Enzyme regulation: In the absence of viral infection, maintained as a monomer in an autoinhibited state and
    phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization
    activities and its nuclear localization where it can activate type I IFN and ISG genes
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for IRF7:
    interferon regulatory factor 7,with three alternatively spliced isoforms,predominantly expressed in spleen,thymus
    and peripheral blood leukocytes regulator (? activator,? repressor) of IFNA,IFN-stimulated genes and Epstein-Barr
    virus

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding ----
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA17404045
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IDA17404045
    GO:0003677DNA binding IMP12374802
    GO:0003700sequence-specific DNA binding transcription factor activity ----
         
    Find genes that share ontologies with IRF7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for IRF7:
     Decreased nuclei size in G2M  Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Irf7):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with IRF7           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Irf7tm1Ttg for IRF7

       genOway: Develop your customized and physiologically relevant rodent model for IRF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target IRF7:
    hsa-mir-146a-5p (MIRT021215)

    Block miRNA regulation of human, mouse, rat IRF7 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat IRF7

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): IRF7 (NM_004029)
    Browse Sino Biological Human cDNA Clones
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    eBioscience FlowRNA Probe Sets ( VA6-13920) for IRF7 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    IRF7_HUMAN, Q92985: Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the
    nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    endosome4
    extracellular1
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9786932
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS9786932
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    Find genes that share ontologies with IRF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for IRF7 About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.94
    Regulation of toll-like receptor signaling pathway0.93
    Toll-like receptor signaling pathway0.94
    Hepatitis B0.31
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    TRAF3-dependent IRF activation pathway0.00
    3Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    DEx/H-box helicases activate type I IFN and inflammatory cytokines production0.00
    Cytosolic DNA-sensing pathway0.33
    4Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    5Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59


    Find genes that share SuperPaths with IRF7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IRF7
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for IRF7
        Toll-Like Receptors Pathway

    1 Cell Signaling Technology (CST) Pathway for IRF7
        NF-kappaB Signaling

    5 BioSystems Pathways for IRF7
        Apoptosis
    Senescence and Autophagy
    Toll-like receptor signaling pathway
    Regulation of nuclear SMAD2/3 signaling
    Regulation of toll-like receptor signaling pathway

    Selected Reactome Pathways for IRF7 (see all 8)
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    Interferon alpha/beta signaling
    Interferon gamma signaling
    TRAF3-dependent IRF activation pathway
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling


    Selected Kegg Pathways  (Kegg details for IRF7) (see all 9):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF7 (see all 8): 
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for IRF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for IRF7 (Q929851, 2, 3 ENSP000003294114) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-968267,EBI-356402 MINT-5208589 MINT-5208568 I2D: score=2 STRING: ENSP00000329967
    CHUKO151111, 3, ENSP000003594244EBI-968267,EBI-81249 I2D: score=2 STRING: ENSP00000359424
    CCDC47Q96A331, 3, ENSP000002257264EBI-968267,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    IRAK1P516171, 3, ENSP000003589974EBI-968267,EBI-358664 I2D: score=4 STRING: ENSP00000358997
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-50623 I2D: score=3 STRING: ENSP00000262971
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9315633
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0002819regulation of adaptive immune response IDA17404045
    GO:0006355regulation of transcription, DNA-templated ----

    Find genes that share ontologies with IRF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for IRF7

    9 Novoseek inferred chemical compound relationships for IRF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 67.1 8 20483755 (3), 18930547 (1), 16186222 (1)
    ifn-alpha 64.9 6 16472772 (1), 18505922 (1), 15880822 (1), 9822609 (1) (see all 5)
    rantes 58.3 12 10893229 (2), 10799898 (2), 10938111 (2), 11390609 (2) (see all 7)
    poly(i-c) 48.9 1 18338949 (1)
    2',5'-oligoadenylate 34.2 1 17267482 (1)
    serine 23.5 11 15743772 (4), 18606014 (1), 18983772 (1), 9822609 (1) (see all 6)
    12-o-tetradecanoylphorbol 13-acetate 18.1 4 11877397 (2), 11585813 (1)
    oligonucleotide 11.7 2 15308637 (1), 19035457 (1)
    alanine 0 1 15743772 (1)



    Find genes that share compounds with IRF7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for IRF7 gene (4 alternative transcripts): 
    NM_001572.3  NM_004029.2  NM_004031.2  NM_004030.1  

    Unigene Cluster for IRF7:

    Interferon regulatory factor 7
    Hs.166120  [show with all ESTs]
    Unigene Representative Sequence: NM_004031
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525445(uc009ycb.3) ENST00000348655 ENST00000397574(uc001lqh.3)
    ENST00000533182(uc010qwh.2) ENST00000528413 ENST00000469048 ENST00000531912
    ENST00000330243 ENST00000532326 ENST00000525750 ENST00000532788 ENST00000527160
    ENST00000532096 ENST00000533190 ENST00000397570(uc001lqi.3) ENST00000397566(uc010qwf.2 uc001lqf.3 uc010qwg.2 uc001lqg.3)
    ENST00000397562
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    Additional mRNA sequence: 

    AF076494.1 AK303752.1 BC136555.1 BC144242.1 U53830.1 U53831.1 U53832.1 U73036.1 

    13 DOTS entries:

    DT.446225  DT.95373071  DT.99972782  DT.120695272  DT.120695318  DT.100792534  DT.100792533  DT.100792526 
    DT.95373070  DT.100792535  DT.120695319  DT.75160532  DT.95373063 

    Selected AceView cDNA sequences (see all 264):

    BF002262 AW294499 BM922613 AW068930 U53831 AI968310 BI911719 CA866695 
    BI818501 BQ278841 CD370601 AI052199 NM_004029 BQ065289 BI489882 CA420912 
    BM993013 CA777969 AA768089 AI262068 AW593499 AI337210 BI769297 CA309914 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for IRF7 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                        -                                                         
    SP2:                                                        -     -                                                   
    SP3:                                                  -     -                                                         
    SP4:                                                        -                                                         
    SP5:                                                  -     -     -                                                   


    ECgene alternative splicing isoforms for IRF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    IRF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAAGTGCA
    IRF7 Expression
    About this image


    IRF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
    IRF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    IRF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.166120

    UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Tissue specificity: Expressed predominantly in spleen, thymus and peripheral blood leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including IRF7 (see all 8): 
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for IRF7
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for IRF7 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf71 , 5 interferon regulatory factor 71, 5 72.86(n)1
    69.69(a)1
      7 (86.57 cM)5
    541231  NM_016850.31  NP_058546.11 
     1412627065 
    chicken
    (Gallus gallus)
    Aves IRF71 interferon regulatory factor 7 55.24(n)
    44.47(a)
      396330  NM_205372.1  NP_990703.1 
    lizard
    (Anolis carolinensis)
    Reptilia IRF76
    interferon regulatory factor 7
    34(a)
    1 ↔ 1
    1(74409264-74435798)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004963951 interferon regulatory factor 3-like 49.07(n)
    42.62(a)
      100496395  XM_002938701.2  XP_002938747.2 
    zebrafish
    (Danio rerio)
    Actinopterygii irf71 interferon regulatory factor 7 44.21(n)
    34.99(a)
      393650  NM_200677.1  NP_956971.1 


    ENSEMBL Gene Tree for IRF7 (if available)
    TreeFam Gene Tree for IRF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for IRF7 gene
    IRF82  IRF22  IRF52  IRF32  IRF42  IRF92  IRF12  IRF62  
    3 SIMAP similar genes for IRF7 using alignment to 7 protein entries:     IRF7_HUMAN (see all proteins):
    IRF9    IRF8    IRF3

    Find genes that share paralogs with IRF7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for IRF7 (see all 288)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs799150701,2
    F--428943(+) CGGGGG/ACAGGA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs1865773131,2
    --428948(+) ACAGGA/CTGTGA 3 -- int10--------
    rs618778531,2
    --428973(+) CGGGGG/ACAGGA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs1838471911,2
    --429002(+) GGGGAC/TAAGCC 3 -- int10--------
    rs1891969441,2
    --429004(+) GGACAA/GGCCGT 3 -- int10--------
    rs1809639841,2
    --549506(+) TAAATC/GTCTAG 3 -- ds50010--------
    rs79435461,2
    C,F--549509(-) CACCTA/GGAGAT 3 -- ds50018Minor allele frequency- G:0.42WA NA 250
    rs1130960531,2
    F--549528(+) CCAACC/AGCTGC 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1132991901,2
    C,F--549537(+) GCTGTG/ATACCT 3 -- ds50013Minor allele frequency- A:0.04WA CSA 122
    rs10553821,2
    C,F,A--549543(+) TACCTT/CTGGCT 3 -- ds500110Minor allele frequency- C:0.48WA NA CSA 252

    HapMap Linkage Disequilibrium report for IRF7 (612553 - 615999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for IRF7 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    nsv896545CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv935n71CNV Loss21882294
    nsv896560CNV Loss21882294
    nsv467635CNV Loss19166990
    dgv916n71CNV Loss21882294
    nsv896569CNV Loss21882294
    dgv922n71CNV Loss21882294
    dgv920n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): IRF7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing IRF7
    DNA2.0 Custom Variant and Variant Library Synthesis for IRF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605047    OMIM disorders: --

    2 diseases for IRF7:    
    About MalaCards
    stomatitis    central nervous system lymphoma

    1 disease from the University of Copenhagen DISEASES database for IRF7:
    Kaposi's sarcoma

    Find genes that share disorders with IRF7           About GenesLikeMe

    9 Novoseek inferred disease relationships for IRF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 71.4 29 16472772 (4), 10893229 (2), 15308637 (2), 17404045 (2) (see all 18)
    vesicular stomatitis 46.1 1 19515829 (1)
    necrosis 32.8 8 11877397 (2), 18710948 (2), 15695821 (1), 11711629 (1) (see all 5)
    tumors 25.6 8 11877397 (2), 18710948 (2), 17942938 (1), 15695821 (1) (see all 5)
    hepatitis c chronic 15.2 2 18397234 (2)
    autoimmune diseases 10.3 1 18227218 (1)
    lymphoma 1.01 6 15542650 (4), 15492278 (1), 17393359 (1)
    cancer 0.793 4 19439102 (1), 19802007 (1), 16846591 (1)
    herpes simplex 0 1 17215277 (1)

    Genetic Association Database (GAD): IRF7
    Human Genome Epidemiology (HuGE) Navigator: IRF7 (12 documents)

    Export disorders for IRF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for IRF7 gene, integrated from 10 sources (see all 276):
    (articles sorted by number of sources associating them with IRF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. (PubMed id 12374802)1, 2, 9 Caillaud A.... Marie I. (J. Biol. Chem. 2002)
    2. IRF-7: new role in the regulation of genes involved in adaptive immunity. (PubMed id 17404045)1, 2, 9 Sgarbanti M.... Battistini A. (Ann. N. Y. Acad. Sci. 2007)
    3. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. (PubMed id 11073981)1, 2, 9 Marie I.J.... Levy D.E. (Mol. Cell. Biol. 2000)
    4. Association of interferon regulatory factor-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients. (PubMed id 18397234)1, 4, 9 Sermasathanasawadi R....Omata M. (Liver Int. 2008)
    5. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. (PubMed id 9786932)1, 2, 9 Au W.-C.... Pitha P.M. (J. Biol. Chem. 1998)
    6. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PubMed id 15361868)1, 2, 9 Kawai T.... Akira S. (Nat. Immunol. 2004)
    7. Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. (PubMed id 20112359)1, 4, 9 Salloum R....Niewold T.B. (Arthritis Rheum. 2010)
    8. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (J. Biol. Chem. 2004)
    9. Epstein-Barr virus LF2: an antagonist to type I interferon. (PubMed id 18987133)1, 2, 9 Wu L.... Jung J.U. (J. Virol. 2009)
    10. Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus. (PubMed id 18539711)1, 4, 9 Akahoshi M....Shirakawa T. (Lupus 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3665 HGNC: 6122 AceView: IRF7 Ensembl:ENSG00000185507 euGenes: HUgn3665
    ECgene: IRF7 Kegg: 3665 H-InvDB: IRF7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for IRF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for IRF7 gene:
    Search GeneIP for patents involving IRF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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