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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRF7 Gene

protein-coding   GIFtS: 64
GCID: GC11M000602

Interferon Regulatory Factor 7

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Interferon Regulatory Factor 71 2     IRF7B2
IRF-72 3     IRF7C2
IRF-7H2     IRF7H2
IRF7A2     Interferon Regulatory Factor-7H2

External Ids:    HGNC: 61221   Entrez Gene: 36652   Ensembl: ENSG000001855077   OMIM: 6050475   UniProtKB: Q929853   

Export aliases for IRF7 gene to outside databases

Previous GC identifers: GC11P001127 GC11P001065 GC11P000583 GC11M000427


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for IRF7 Gene:
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF)
family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes,
including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue.
Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not
yet been established. (provided by RefSeq, Jul 2008)

GeneCards Summary for IRF7 Gene: 
IRF7 (interferon regulatory factor 7) is a protein-coding gene. Diseases associated with IRF7 include stomatitis, and central nervous system lymphoma, and among its related super-pathways are Toll-like receptor signaling pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is IRF8.

UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical
role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes
(IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element
(ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and
mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated,
MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more
critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells
and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes
phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and
nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG
genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either
directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may
play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and
regulate the anti-tumor properties of primary macrophages

Gene Wiki entry for IRF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRF7 gene promoter:
         p300   STAT3   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IRF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IRF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000602:  view genomic region     (about GC identifiers)

Start:
612,553 bp from pter      End:
615,999 bp from pter
Size:
3,447 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985 (See protein sequence)
Recommended Name: Interferon regulatory factor 7  
Size: 503 amino acids; 54278 Da
Subunit: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2.
Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7.
Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6
Subcellular location: Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the
nucleus
1 PDB 3D structure from and Proteopedia for IRF7:
2O61 (3D)    
Secondary accessions: B9EGL3 O00331 O00332 O00333 O75924 Q9UE79
Alternative splicing: 4 isoforms:  Q92985-1   Q92985-2   Q92985-3   Q92985-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IRF7: NX_Q92985

Explore proteomics data for IRF7 at MOPED 

Post-translational modifications:

  • UniProtKB: Acetylation inhibits its DNA-binding ability and activity
  • UniProtKB: In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and
    subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway,
    phosphorylated by IRAK1
  • UniProtKB: TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity)
  • UniProtKB: Sumoylated by TRIM28, which inhibits its transactivation activity
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92985

  • IRF7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    IRF7 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001563.2  NP_004020.1  NP_004022.2  

    ENSEMBL proteins: 
     ENSP00000434009   ENSP00000331803   ENSP00000380704   ENSP00000433903   ENSP00000434607  
     ENSP00000329411   ENSP00000436696   ENSP00000432403   ENSP00000434524   ENSP00000380700  
     ENSP00000380697   ENSP00000380693  
    Reactome Protein details: Q92985
    Human Recombinant Protein Products for IRF7: 
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    Cloud-Clone Corp. Proteins for IRF7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9786932
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS9786932
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane TAS--

    IRF7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR008984 SMAD_FHA_domain
     IPR019817 Interferon_reg_fac_CS
     IPR019471 Interferon_reg_factor-3
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q92985

    ProtoNet protein and cluster: Q92985

    1 Blocks protein domain: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    IRF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: IRF7_HUMAN, Q92985
    Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical
    role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes
    (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element
    (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and
    mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated,
    MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more
    critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells
    and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes
    phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and
    nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG
    genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either
    directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may
    play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and
    regulate the anti-tumor properties of primary macrophages
    Enzyme regulation: In the absence of viral infection, maintained as a monomer in an autoinhibited state and
    phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization
    activities and its nuclear localization where it can activate type I IFN and ISG genes
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for IRF7:
    interferon regulatory factor 7,with three alternatively spliced isoforms,predominantly expressed in spleen,thymus
    and peripheral blood leukocytes regulator (? activator,? repressor) of IFNA,IFN-stimulated genes and Epstein-Barr
    virus

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding ----
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA17404045
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IDA17404045
    GO:0003677DNA binding IMP12374802
    GO:0003700sequence-specific DNA binding transcription factor activity ----
         
    IRF7 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for IRF7:
     Decreased nuclei size in G2M  Synthetic lethal with imatinib 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Irf7):
     homeostasis/metabolism  immune system 

    IRF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Irf7tm1Ttg for IRF7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for IRF7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for IRF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for IRF7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for IRF7 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for IRF7 About   (see all 20)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Toll-like receptor signaling pathway
    Toll-like receptor signaling pathway0.93
    Hepatitis B0.31
    Toll-like receptor signaling pathway0.93
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52
    3Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    Cytosolic sensors of pathogen-associated DNA 0.36
    4TRAF6 Mediated Induction of proinflammatory cytokines
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.92
    Toll Like Receptor 3 (TLR3) Cascade0.87
    MyD88 dependent cascade initiated on endosome0.92
    Toll Like Receptor 4 (TLR4) Cascade0.87
    Toll Like Receptor 9 (TLR9) Cascade0.89
    Toll-Like Receptors Cascades0.87
    Activated TLR4 signalling0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    5Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for IRF7
        NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IRF7
        Toll-Like Receptors Pathway

    1 Cell Signaling Technology (CST) Pathway for IRF7
        NF-kappaB Signaling

    4 BioSystems Pathways for IRF7
        Apoptosis
    Senescence and Autophagy
    Toll-like receptor signaling pathway
    Regulation of nuclear SMAD2/3 signaling

    5/22        Reactome Pathways for IRF7 (see all 22)
        DEx/H-box helicases activate type I IFN and inflammatory cytokines production
    Interferon alpha/beta signaling
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    TRAF6 mediated IRF7 activation


    5/9         Kegg Pathways  (Kegg details for IRF7) (see all 9):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Hepatitis B


    IRF7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/119 Interacting proteins for IRF7 (Q929851, 2, 3 ENSP000003294114) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD22, 3, ENSP000003299674MINT-5208589 MINT-5208568 I2D: score=2 STRING: ENSP00000329967
    CHUKO151111, 3, ENSP000003594244EBI-968267,EBI-81249 I2D: score=2 STRING: ENSP00000359424
    CCDC47Q96A331, 3, ENSP000002257264EBI-968267,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    IRAK1P516171, 3, ENSP000003589974EBI-968267,EBI-358664 I2D: score=4 STRING: ENSP00000358997
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-50623 I2D: score=3 STRING: ENSP00000262971
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9315633
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0002819regulation of adaptive immune response IDA17404045
    GO:0006355regulation of transcription, DNA-dependent ----

    IRF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRF7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for IRF7

    9 Novoseek inferred chemical compound relationships for IRF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 67.1 8 20483755 (3), 18930547 (1), 16186222 (1)
    ifn-alpha 64.9 6 16472772 (1), 18505922 (1), 15880822 (1), 9822609 (1) (see all 5)
    rantes 58.3 12 10893229 (2), 10799898 (2), 10938111 (2), 11390609 (2) (see all 7)
    poly(i-c) 48.9 1 18338949 (1)
    2',5'-oligoadenylate 34.2 1 17267482 (1)
    serine 23.5 11 15743772 (4), 18606014 (1), 18983772 (1), 9822609 (1) (see all 6)
    12-o-tetradecanoylphorbol 13-acetate 18.1 4 11877397 (2), 11585813 (1)
    oligonucleotide 11.7 2 15308637 (1), 19035457 (1)
    alanine 0 1 15743772 (1)

    Search CenterWatch for drugs/clinical trials and news about IRF7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for IRF7 gene (4 alternative transcripts): 
    NM_001572.3  NM_004029.2  NM_004031.2  NM_004030.1  

    Unigene Cluster for IRF7:

    Interferon regulatory factor 7
    Hs.166120  [show with all ESTs]
    Unigene Representative Sequence: NM_004031
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525445(uc009ycb.3) ENST00000348655 ENST00000397574(uc001lqh.3)
    ENST00000533182(uc010qwh.2) ENST00000528413 ENST00000469048 ENST00000531912
    ENST00000330243 ENST00000532326 ENST00000525750 ENST00000532788 ENST00000527160
    ENST00000532096 ENST00000533190 ENST00000397570(uc001lqi.3) ENST00000397566(uc010qwf.2 uc001lqf.3 uc010qwg.2 uc001lqg.3)
    ENST00000397562
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF076494.1 AK303752.1 BC136555.1 BC144242.1 U53830.1 U53831.1 U53832.1 U73036.1 

    13 DOTS entries:

    DT.446225  DT.95373071  DT.99972782  DT.120695272  DT.120695318  DT.100792534  DT.100792533  DT.100792526 
    DT.95373070  DT.100792535  DT.120695319  DT.75160532  DT.95373063 

    24/264 AceView cDNA sequences (see all 264):

    CA307999 CA777969 NM_004029 CA309914 CD370601 AU106561 AA768089 AW294499 
    BQ058226 BM714068 NM_004030 BM849172 BM918595 AI864192 CA420912 AI651770 
    AI968310 BI911719 U53832 BM713888 AI337210 NM_001572 BI489882 BM993013 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IRF7 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                        -                                                         
    SP2:                                                        -     -                                                   
    SP3:                                                  -     -                                                         
    SP4:                                                        -                                                         
    SP5:                                                  -     -     -                                                   


    ECgene alternative splicing isoforms for IRF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRF7 expression in normal human tissues (normalized intensities)      IRF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAAGTGCA
    IRF7 Expression
    About this image


    IRF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 5 entries
             colon ; peripheral nerve/ganglion   
             colonic mucosal (ibs)   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See IRF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRF7

    SOURCE GeneReport for Unigene cluster: Hs.166120

    UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Tissue specificity: Expressed predominantly in spleen, thymus and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IRF7 (see all 8): 
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for IRF7 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Irf71 , 5 interferon regulatory factor 71, 5 72.86(n)1
    69.69(a)1
      7 (86.57 cM)5
    541231  NM_016850.31  NP_058546.11 
     1412627065 
    chicken
    (Gallus gallus)
    Aves IRF-36
    interferon regulatory factor 3
    32(a)
    1 ↔ 1
    5(15206202-15209669)
    lizard
    (Anolis carolinensis)
    Reptilia IRF76
    Uncharacterized protein
    28(a)
    1 ↔ 1
    1(74409264-74435798)
    zebrafish
    (Danio rerio)
    Actinopterygii irf76
    interferon regulatory factor 7
    28(a)
    1 ↔ 1
    25(26412229-26416395)


    ENSEMBL Gene Tree for IRF7 (if available)
    TreeFam Gene Tree for IRF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRF7 gene
    IRF82  IRF22  IRF52  IRF32  IRF42  IRF92  IRF12  IRF62  
    3 SIMAP similar genes for IRF7 using alignment to 7 protein entries:     IRF7_HUMAN (see all proteins):
    IRF9    IRF8    IRF3

    IRF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/288 SNPs in IRF7 are shown (see all 288)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs799150701,2
    F--428943(+) CGGGGG/ACAGGA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs1865773131,2
    --428948(+) ACAGGA/CTGTGA 3 -- int10--------
    rs618778531,2
    --428973(+) CGGGGG/ACAGGA 3 -- int11Minor allele frequency- A:0.50NA 2
    rs1838471911,2
    --429002(+) GGGGAC/TAAGCC 3 -- int10--------
    rs1891969441,2
    --429004(+) GGACAA/GGCCGT 3 -- int10--------
    rs1809639841,2
    --549506(+) TAAATC/GTCTAG 3 -- ds50010--------
    rs79435461,2
    C,F--549509(-) CACCTA/GGAGAT 3 -- ds50018Minor allele frequency- G:0.42WA NA 250
    rs1130960531,2
    F--549528(+) CCAACC/AGCTGC 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1132991901,2
    C,F--549537(+) GCTGTG/ATACCT 3 -- ds50013Minor allele frequency- A:0.04WA CSA 122
    rs10553821,2
    C,F,A--549543(+) TACCTT/CTGGCT 3 -- ds500110Minor allele frequency- C:0.48WA NA CSA 252

    HapMap Linkage Disequilibrium report for IRF7 (612553 - 615999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for IRF7 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    nsv896545CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv935n71CNV Loss21882294
    nsv896560CNV Loss21882294
    nsv467635CNV Loss19166990
    dgv916n71CNV Loss21882294
    nsv896569CNV Loss21882294
    dgv922n71CNV Loss21882294
    dgv920n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): IRF7
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IRF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605047    OMIM disorders: --

    20/29 diseases for IRF7 (see all 29):    About MalaCards
    stomatitis    central nervous system lymphoma    cutaneous lupus erythematosus    newcastle disease
    vaccinia    dengue hemorrhagic fever    rabies    herpes simplex
    hemorrhagic fever    measles    kaposi's sarcoma    hepatitis c
    lupus erythematosus    systemic lupus erythematosus    liver cirrhosis    influenza
    periodontitis    psoriasis    astrocytoma    sarcoma

    1 disease from the University of Copenhagen DISEASES database for IRF7:
    Kaposi's sarcoma

    IRF7 for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for IRF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 71.4 29 16472772 (4), 10893229 (2), 15308637 (2), 17404045 (2) (see all 18)
    vesicular stomatitis 46.1 1 19515829 (1)
    necrosis 32.8 8 11877397 (2), 18710948 (2), 15695821 (1), 11711629 (1) (see all 5)
    tumors 25.6 8 11877397 (2), 18710948 (2), 17942938 (1), 15695821 (1) (see all 5)
    hepatitis c chronic 15.2 2 18397234 (2)
    autoimmune diseases 10.3 1 18227218 (1)
    lymphoma 1.01 6 15542650 (4), 15492278 (1), 17393359 (1)
    cancer 0.793 4 19439102 (1), 19802007 (1), 16846591 (1)
    herpes simplex 0 1 17215277 (1)

    Genetic Association Database (GAD): IRF7
    Human Genome Epidemiology (HuGE) Navigator: IRF7 (12 documents)

    Export disorders for IRF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRF7 gene, integrated from 9 sources (see all 270):
    (articles sorted by number of sources associating them with IRF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. (PubMed id 12374802)1, 2, 9 Caillaud A....Marie I. (2002)
    2. IRF-7: new role in the regulation of genes involved in adaptive immunity. (PubMed id 17404045)1, 2, 9 Sgarbanti M....Battistini A. (2007)
    3. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. (PubMed id 11073981)1, 2, 9 Marie I.J.... Levy D.E. (2000)
    4. Association of interferon regulatory factor-7 gene polymorphism with liver cirrhosis in chronic hepatitis C patients. (PubMed id 18397234)1, 4, 9 Sermasathanasawadi R....Omata M. (2008)
    5. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. (PubMed id 9786932)1, 2, 9 Au W.-C.... Pitha P.M. (1998)
    6. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PubMed id 15361868)1, 2, 9 Kawai T....Akira S. (2004)
    7. Genetic variation at the IRF7/PHRF1 locus is associat ed with autoantibody profile and serum interferon-alpha activity in lupus patie nts. (PubMed id 20112359)1, 4, 9 Salloum R....Niewold T.B. (2010)
    8. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (2004)
    9. Epstein-Barr virus LF2: an antagonist to type I interferon. (PubMed id 18987133)1, 2, 9 Wu L.... Jung J.U. (2009)
    10. Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus. (PubMed id 18539711)1, 4, 9 Akahoshi M....Shirakawa T. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3665 HGNC: 6122 AceView: IRF7 Ensembl:ENSG00000185507 euGenes: HUgn3665
    ECgene: IRF7 Kegg: 3665 H-InvDB: IRF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for IRF7 gene:
    Search GeneIP for patents involving IRF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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