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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

IRF7 Gene

protein-coding   GIFtS: 62
GCID: GC11M000602

interferon regulatory factor 7
 Explore 27 diseases affiliated with
IRF7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for IRF7    

Aliases
for IRF7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Interferon Regulatory Factor 71 2
IRF-72 3
IRF-7H2
IRF7A2
Interferon Regulatory Factor-7H2

External Ids:    HGNC: 61221   Entrez Gene: 36652   Ensembl: ENSG000001855077   OMIM: 6050475   UniProtKB: Q929853   

Export aliases for IRF7 gene to outside databases

Previous GC identifers: GC11P001127 GC11P001065 GC11P000583 GC11M000427


Summaries
for IRF7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for IRF7:
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family.
IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including
interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7
transcript variants have been identified, although the functional consequences of these have not yet been established.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role
in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha
and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their
promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their
induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway.
Required during both the early and late phases of the IFN gene induction but is more critical for the late than for
the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection,
double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases.
This induces a conformational change, leading to its dimerization and nuclear localization where along with other
coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating
adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to
the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can
activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary
macrophages

Gene Wiki entry for IRF7


Genomic Views
for IRF7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the IRF7 gene promoter:
         p300   STAT3   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): IRF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for IRF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5

IRF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
IRF7 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M000602:  view genomic region     (about GC identifiers)

Start:
 612,553 bp from pter      End:
 615,999 bp from pter
Size:
 3,447 bases      Orientation:
 minus strand

Proteins
for IRF7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985 (See protein sequence)
Recommended Name: Interferon regulatory factor 7  
Size: 503 amino acids; 54278 Da
Subunit: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2.
Interacts with rotavirus A NSP1; this interaction leads to the proteasome-dependent degradation of IRF7. Interacts
with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6
Subcellular location: Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the
nucleus
1 PDB 3D structure from and Proteopedia for IRF7:
2O61 (3D)    
Secondary accessions: B9EGL3 O00331 O00332 O00333 O75924 Q9UE79
Alternative splicing: 4 isoforms:  Q92985-1   Q92985-2   Q92985-3   Q92985-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for IRF7: NX_Q92985

Post-translational modifications:

  • Acetylation inhibits its DNA-binding ability and activity1
  • In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and
    • subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway,
    phosphorylated by IRAK11
  • TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity)1
  • Sumoylated by TRIM28, which inhibits its transactivation activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92985

    • IRF7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001563.2  NP_004020.1  NP_004022.2  

    ENSEMBL proteins: 
     ENSP00000434009   ENSP00000331803   ENSP00000380704   ENSP00000433903   ENSP00000434607  
     ENSP00000329411   ENSP00000436696   ENSP00000432403   ENSP00000434524   ENSP00000380700  
     ENSP00000380697   ENSP00000380693  
    Reactome Protein details: Q92985
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: IRF7
    OriGene Protein Over-expression Lysate (see all 3): IRF7
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    Novus Biologicals IRF7 Proteins
    Novus Biologicals IRF7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for IRF7

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9786932
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm TAS9786932
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ----


    IRF7 for ontologies           About GeneDecksing



    IRF7 Antibody Products: 
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    ThermoFisher Antibodies for IRF7

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    Uscn ELISAs and CLIAs for IRF7

    Protein Domains /
    Families
    for IRF7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IRF7 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR001346 Interferon_reg_fact_DNA-bd_dom
     IPR008984 SMAD_FHA_domain
     IPR019817 Interferon_reg_fac_CS
     IPR017855 SMAD_dom-like

    Graphical View of Domain Structure for InterPro Entry Q92985

    ProtoNet protein and cluster: Q92985

    1 Blocks protein family: IPB001346 Interferon regulatory factor

    UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Similarity: Belongs to the IRF family
    Similarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain


    Function
    for IRF7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Function: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role
    in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha
    and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their
    promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their
    induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway.
    Required during both the early and late phases of the IFN gene induction but is more critical for the late than for
    the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection,
    double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases.
    This induces a conformational change, leading to its dimerization and nuclear localization where along with other
    coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating
    adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to
    the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can
    activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary
    macrophages
    Enzyme regulation: In the absence of viral infection, maintained as a monomer in an autoinhibited state and
    phosphorylation disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities
    and its nuclear localization where it can activate type I IFN and ISG genes
    Induction: By type I interferon (IFN) and viruses

         Genatlas biochemistry entry for IRF7:
    interferon regulatory factor 7,with three alternatively spliced isoforms,predominantly expressed in spleen,thymus and
    peripheral blood leukocytes regulator (? activator,? repressor) of IFNA,IFN-stimulated genes and Epstein-Barr virus

    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF7 (see all 7)
    OriGene shRNA RFP: IRF7
    OriGene siRNA: IRF7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for IRF7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF7 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): IRF7 (NM_004029)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF7 

    Cell Line
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    Search LifeMap BioReagents cell lines for IRF7

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF7

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000975regulatory region DNA binding ----
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IDA17404045
    GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IDA17404045
    GO:0003677DNA binding IMP12374802
    GO:0003700sequence-specific DNA binding transcription factor activity ----


    IRF7 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for IRF7:
     Decreased nuclei size in G2M  Synthetic lethal with imatinib 

    Animal Models:
         Mouse knock-out Irf7tm1Ttg for IRF7
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Irf7):
     homeostasis/metabolism  immune system 

    IRF7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for IRF7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1TRAF6 Mediated Induction of proinflammatory cytokines
    8/9 pathways (see all 9)
    		Toll Like Receptor 7/8 (TLR7/8) Cascade0.83
    		Toll Like Receptor 3 (TLR3) Cascade0.72
    		MyD88 dependent cascade initiated on endosome0.83
    		Activated TLR4 signalling0.63
    		Toll Like Receptor 9 (TLR9) Cascade0.81
    		Toll Like Receptor 4 (TLR4) Cascade0.61
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    		Toll-Like Receptors Cascades0.53
    2Toll-like receptor signaling pathway
    		Toll-like receptor signaling pathway1.00
    		Toll-Like receptor Signaling Pathways0.51
    		Toll-like receptor signaling pathway0.97
    3Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    5Expression of IFN-induced genes
    		Expression of IFN-induced genes1.00
    		Interferon alpha/beta signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 R&D Systems Pathway for IRF7
        Toll-Like receptor Signaling Pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for IRF7
        Toll-Like Receptors Pathway

    1 Cell Signaling Technology (CST) Pathway for IRF7
        NF-kappaB Signaling

    4 BioSystems Pathways for IRF7 
        Senescence and Autophagy
    Apoptosis
    Toll-like receptor signaling pathway
    Regulation of nuclear SMAD2/3 signaling

    5/22        Reactome Pathways for IRF7 (see all 22)
        Interferon alpha/beta signaling
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Expression of IFN-induced genes
    TRAF6 mediated IRF7 activation


    5/6         Kegg Pathways  (Kegg details for IRF7) (see all 6):
        Toll-like receptor signaling pathway
    RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway
    Hepatitis C
    Measles


    IRF7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/118 Interacting proteins for IRF7 (Q929851, 2, 3 ENSP000003294114) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD22, 3, ENSP000003299674MINT-5208589 MINT-5208568 I2D: score=2 STRING: ENSP00000329967
    CCDC47Q96A331, 3, ENSP000002257264EBI-2339383,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    IRAK1P516171, 3, ENSP000003589974EBI-2339383,EBI-358664 I2D: score=4 STRING: ENSP00000358997
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-50623 I2D: score=3 STRING: ENSP00000262971
    AIPO001701, 3, ENSP000002791464EBI-2339383,EBI-704197 I2D: score=1 STRING: ENSP00000279146
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS9315633
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0002819regulation of adaptive immune response IDA17404045
    GO:0006366transcription from RNA polymerase II promoter TAS9315633
    GO:0006468protein phosphorylation IDA12374802


    IRF7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for IRF7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    IRF7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for IRF7
    9 Novoseek chemical compound relationships for IRF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polyinosinic-polycytidylic acid 67.1 8 20483755 (3), 18930547 (1), 16186222 (1)
    ifn-alpha 64.9 6 16472772 (1), 18505922 (1), 15880822 (1), 9822609 (1) (see all 5)
    rantes 58.3 12 10893229 (2), 10799898 (2), 10938111 (2), 11390609 (2) (see all 7)
    poly(i-c) 48.9 1 18338949 (1)
    2',5'-oligoadenylate 34.2 1 17267482 (1)
    serine 23.5 11 15743772 (4), 18606014 (1), 18983772 (1), 9822609 (1) (see all 6)
    12-o-tetradecanoylphorbol 13-acetate 18.1 4 11877397 (2), 11585813 (1)
    oligonucleotide 11.7 2 15308637 (1), 19035457 (1)
    alanine 0 1 15743772 (1)

    Search CenterWatch for drugs/clinical trials and news about IRF7 

    Transcripts
    for IRF7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for IRF7 gene (4 alternative transcripts): 
    NM_001572.3  NM_004029.2  NM_004031.2  NM_004030.1  

    Unigene Cluster for IRF7:

    Interferon regulatory factor 7
    Hs.166120  [show with all ESTs]
    Unigene Representative Sequence: NM_004031
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525445(uc009ycb.3) ENST00000348655 ENST00000397574(uc001lqh.3)
    ENST00000533182(uc010qwh.2) ENST00000528413 ENST00000469048 ENST00000531912
    ENST00000330243 ENST00000532326 ENST00000534109 ENST00000525750 ENST00000532788
    ENST00000527160 ENST00000532096 ENST00000533190 ENST00000397570(uc001lqi.3)
    ENST00000397566(uc010qwf.2 uc001lqf.3 uc010qwg.2 uc001lqg.3)
    ENST00000397562

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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF7 (see all 7)
    OriGene shRNA RFP: IRF7
    OriGene siRNA: IRF7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF7
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): IRF7 (NM_004029)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF7 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF7

    Additional cDNA sequence: 

    AF076494.1 AK303752.1 BC136555.1 BC144242.1 U53830.1 U53831.1 U53832.1 U73036.1 

    13 DOTS entries:

    DT.446225  DT.95373071  DT.99972782  DT.120695272  DT.120695318  DT.100792534  DT.100792533  DT.100792526 
    DT.95373070  DT.100792535  DT.120695319  DT.75160532  DT.95373063 

    24/264 AceView cDNA sequences (see all 264):

    AI052199 BI489882 U53830 CA777969 BI769297 BM918423 AI651770 AI864192 
    BM714068 AI968310 AW593499 BQ058226 BM849172 CA307999 CA309914 BQ065289 
    AA768089 CD370601 NM_004029 U53831 BI911719 BM993013 CA420912 BM713888 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for IRF7 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c · 12d
    SP1:                                                        -                                                         
    SP2:                                                        -     -                                                   
    SP3:                                                  -     -                                                         
    SP4:                                                        -                                                         
    SP5:                                                  -     -     -                                                   


    ECgene alternative splicing isoforms for IRF7

    Expression
    for IRF7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    IRF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAAGTGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See IRF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for IRF7

    SOURCE GeneReport for Unigene cluster: Hs.166120

    UniProtKB/Swiss-Prot: IRF7_HUMAN, Q92985
    Tissue specificity: Expressed predominantly in spleen, thymus and peripheral blood leukocytes

        SABiosciences Expression via Pathway-Focused PCR Arrays including IRF7 (see all 8): 
              Antiviral Response in human mouse rat
              Interferons & Receptors in human mouse rat
              Inflammatory Response & Autoimmunity 384HT in human mouse rat
              Antibacterial Response in human mouse rat
              Innate & Adaptive Immune Responses in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for IRF7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for IRF7 gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves IRF76
    		 interferon regulatory factor 7
    		 36(a)
    		 1 ↔ 1
    		 5(16950112-16954483)
    lizard
    (Anolis carolinensis)    		 Reptilia IRF76
    		 --
    		 31(a)
    		 1 ↔ 1
    		 1(74411882-74435783)
    zebrafish
    (Danio rerio)    		 Actinopterygii irf76
    		 interferon regulatory factor 7
    		 29(a)
    		 1 ↔ 1
    		 25(26412229-26416395)


    ENSEMBL Gene Tree for IRF7 (if available)
    TreeFam Gene Tree for IRF7 (if available) 

    Paralogs
    for IRF7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for IRF7 gene
    IRF82  IRF22  IRF52  IRF32  IRF42  IRF92  IRF12  IRF62  
    5 SIMAP similar genes for IRF7 using alignment to 6 protein entries:     IRF7_HUMAN (see all proteins):
    IRF9    IRF3    IRF8    IRF6    IRF5

    IRF7 for paralogs           About GeneDecksing



    Genomic Variants
    for IRF7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 NCBI SNPs in IRF7 are shown (see all 156)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1130960531,2
    		--427472(+) CCAACC/AGCTGC 3 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1132991901,2
    		C,F,--427481(+) GCTGTG/ATACCT 3 -- ds50013Minor allele frequency- A:0.04WA CSA 122
    rs355299691,2
    		C--429308(+) GAGCCC/TTGGGC 5 R G int1 mis10--------
    rs118285451,2
    		C,H,--429944(+) GCTCTC/GCACCT 3 -- int11Minor allele frequency- G:0.17NA 6
    rs22772701,2
    		C,--431132(+) GGGTCA/GCGGAG 3 -- us2k1 int10--------
    rs577036751,2
    		C,--431186(+) GGGGTC/ACCCAG 3 -- int1 us2k11Minor allele frequency- A:0.50WA 2
    rs734003071,2
    		C,F,--432275(+) ATCTCC/TGGTGC 3 -- us2k16Minor allele frequency- T:0.10WA CSA NA 246
    rs356005721,2
    		C,F,--432496(+) ATGGGA/GCCCCC 3 -- us2k16Minor allele frequency- G:0.47NA WA CSA 245
    rs344493801,2
    		C,F,--432503(+) CCCCAT/GGGACC 3 -- us2k17Minor allele frequency- G:0.47NA WA CSA 246
    rs1120063291,2
    		C,F,--432510(+) GACCCG/ACGCGC 3 -- us2k16Minor allele frequency- A:0.46NA CSA WA 244

    HapMap Linkage Disequilibrium report for IRF7 (612553 - 615999 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for IRF7
         4 CNVs: 3831 29884 29882 29883
    Human Gene Mutation Database (HGMD): IRF7

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for IRF7

    Disorders / Diseases
    for IRF7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    IRF7 for disorders           About GeneDecksing

    OMIM gene information: 605047    OMIM disorders: --

    20/27 diseases for IRF7 (see all 27):    About MalaCards
    central nervous system lymphoma    dengue hemorrhagic fever    hemorrhagic fever    herpes simplex
    lupus erythematosus    cutaneous lupus erythematosus    systemic lupus erythematosus    newcastle disease
    hepatitis c    stomatitis    kaposi's sarcoma    liver cirrhosis
    rabies    measles    vaccinia    sarcoma
    hepatocellular carcinoma    periodontitis    ovarian cancer    hepatitis

    9 Novoseek disease relationships for IRF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 71.4 29 16472772 (4), 10893229 (2), 15308637 (2), 17404045 (2) (see all 18)
    vesicular stomatitis 46.1 1 19515829 (1)
    necrosis 32.8 8 11877397 (2), 18710948 (2), 15695821 (1), 11711629 (1) (see all 5)
    tumors 25.6 8 11877397 (2), 18710948 (2), 17942938 (1), 15695821 (1) (see all 5)
    hepatitis c chronic 15.2 2 18397234 (2)
    autoimmune diseases 10.3 1 18227218 (1)
    lymphoma 1.01 6 15542650 (4), 15492278 (1), 17393359 (1)
    cancer 0.793 4 19439102 (1), 19802007 (1), 16846591 (1)
    herpes simplex 0 1 17215277 (1)

    Human Genome Epidemiology (HuGE) Navigator: IRF7 (12 documents)

    Export disorders for IRF7 gene to outside databases

    Publications
    for IRF7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for IRF7 gene, integrated from 9 sources (see all 263):
    (articles sorted by number of sources associating them with IRF7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. (PubMed id 12374802)1, 2, 9 Caillaud A....Marie I. (2002)
    2. IRF-7: new role in the regulation of genes involved in adaptive immunity. (PubMed id 17404045)1, 2, 9 Sgarbanti M....Battistini A. (2007)
    3. Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain. (PubMed id 11073981)1, 2, 9 Marie I.J.... Levy D.E. (2000)
    4. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. (PubMed id 9786932)1, 2, 9 Au W.-C.... Pitha P.M. (1998)
    5. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PubMed id 15361868)1, 2, 9 Kawai T....Akira S. (2004)
    6. Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. (PubMed id 14739303)1, 2, 9 Han K.J.... Shu H.-B. (2004)
    7. Epstein-Barr virus LF2: an antagonist to type I interferon. (PubMed id 18987133)1, 2, 9 Wu L.... Jung J.U. (2009)
    8. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. (PubMed id 14517278)1, 2, 9 Fitzgerald K.A.... Golenbock D.T. (2003)
    9. Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. (PubMed id 21940674)1, 2 Liang Q.... Zhu F. (2011)
    10. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. (PubMed id 16979567)1, 2 Honda K.... Taniguchi T. (2006)

    External Searches for IRF7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing IRF7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3665 HGNC: 6122 AceView: IRF7 Ensembl:ENSG00000185507 euGenes: HUgn3665
    ECgene: IRF7 Kegg: 3665 H-InvDB: IRF7

    Other Databases showing IRF7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing IRF7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for IRF7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for IRF7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for IRF7 gene:
    Search GeneIP for patents involving IRF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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