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Aliases for IRF5 Gene

Aliases for IRF5 Gene

  • Interferon Regulatory Factor 5 2 3
  • SLEB10 3 6
  • IBD14 6
  • IRF-5 4

External Ids for IRF5 Gene

Summaries for IRF5 Gene

Entrez Gene Summary for IRF5 Gene

  • This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]

GeneCards Summary for IRF5 Gene

IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include systemic lupus erythematosus 10 and inflammatory bowel disease 14. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and regulatory region DNA binding. An important paralog of this gene is IRF3.

UniProtKB/Swiss-Prot for IRF5 Gene

  • Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.

Gene Wiki entry for IRF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRF5 Gene

Genomics for IRF5 Gene

Genomic Location for IRF5 Gene

Start:
128,937,612 bp from pter
End:
128,950,035 bp from pter
Size:
12,424 bases
Orientation:
Plus strand

Genomic View for IRF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for IRF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRF5 Gene

Regulatory Elements for IRF5 Gene

Transcription factor binding sites by QIAGEN in the IRF5 gene promoter:

Proteins for IRF5 Gene

  • Protein details for IRF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13568-IRF5_HUMAN
    Recommended name:
    Interferon regulatory factor 5
    Protein Accession:
    Q13568
    Secondary Accessions:
    • A4D1J8
    • A8DUA8
    • A8DUA9
    • E7EQ16
    • E7EW54
    • Q1A7B4
    • Q64GA9
    • Q64GB1
    • Q64GB2
    • Q6RCM8
    • Q9BQF0

    Protein attributes for IRF5 Gene

    Size:
    498 amino acids
    Molecular mass:
    56044 Da
    Quaternary structure:
    • Homodimer, when phosphorylated.

    Three dimensional structures from OCA and Proteopedia for IRF5 Gene

    Alternative splice isoforms for IRF5 Gene

neXtProt entry for IRF5 Gene

Proteomics data for IRF5 Gene at MOPED

Post-translational modifications for IRF5 Gene

  • Lys-63-linked polyubiquitination by TRAF6 is required for activation.
  • Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys411 and Lys412

No data available for DME Specific Peptides for IRF5 Gene

Domains for IRF5 Gene

UniProtKB/Swiss-Prot:

IRF5_HUMAN
Domain:
  • Contains 1 IRF tryptophan pentad repeat DNA-binding domain.:
    • Q13568
Family:
  • Belongs to the IRF family.:
    • Q13568
genes like me logo Genes that share domains with IRF5: view

No data available for Gene Families for IRF5 Gene

Function for IRF5 Gene

Molecular function for IRF5 Gene

GENATLAS Biochemistry: interferon regulatory factor 5,56kDa
UniProtKB/Swiss-Prot Function: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.

Gene Ontology (GO) - Molecular Function for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000975 regulatory region DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 20237317
genes like me logo Genes that share ontologies with IRF5: view
genes like me logo Genes that share phenotypes with IRF5: view

Animal Models for IRF5 Gene

MGI Knock Outs for IRF5:

miRNA for IRF5 Gene

miRTarBase miRNAs that target IRF5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for IRF5 Gene

Localization for IRF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRF5 Gene

Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IRF5 Gene COMPARTMENTS Subcellular localization image for IRF5 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 3
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22412986
GO:0005737 cytoplasm IDA 22412986
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with IRF5: view

Pathways for IRF5 Gene

genes like me logo Genes that share pathways with IRF5: view

Gene Ontology (GO) - Biological Process for IRF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032494 response to peptidoglycan IDA 22412986
GO:0032495 response to muramyl dipeptide IDA 22412986
genes like me logo Genes that share ontologies with IRF5: view

Compounds for IRF5 Gene

(2) Novoseek inferred chemical compound relationships for IRF5 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 1.4 3
vegf 0 1
genes like me logo Genes that share compounds with IRF5: view

Transcripts for IRF5 Gene

Unigene Clusters for IRF5 Gene

Interferon regulatory factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IRF5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - -

Relevant External Links for IRF5 Gene

GeneLoc Exon Structure for
IRF5
ECgene alternative splicing isoforms for
IRF5

Expression for IRF5 Gene

mRNA expression in normal human tissues for IRF5 Gene

mRNA differential expression in normal tissues according to GTEx for IRF5 Gene

This gene is overexpressed in Whole Blood (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for IRF5 Gene

SOURCE GeneReport for Unigene cluster for IRF5 Gene Hs.521181

genes like me logo Genes that share expressions with IRF5: view

Orthologs for IRF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IRF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRF5 36
  • 99.74 (n)
  • 99.81 (a)
IRF5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRF5 36
  • 86.91 (n)
  • 86.84 (a)
IRF5 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRF5 36
  • 90.71 (n)
  • 91.78 (a)
IRF5 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irf5 36
  • 85.22 (n)
  • 87.5 (a)
Irf5 16
Irf5 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRF5 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRF5 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Irf5 36
  • 86.02 (n)
  • 88.51 (a)
chicken
(Gallus gallus)
Aves IRF5 36
  • 65.05 (n)
  • 60.22 (a)
IRF5 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 24 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii irf5 37
  • 52 (a)
OneToOne
Species with no ortholog for IRF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRF5 Gene

ENSEMBL:
Gene Tree for IRF5 (if available)
TreeFam:
Gene Tree for IRF5 (if available)

Paralogs for IRF5 Gene

Paralogs for IRF5 Gene

Pseudogenes.org Pseudogenes for IRF5 Gene

genes like me logo Genes that share paralogs with IRF5: view

Variants for IRF5 Gene

Sequence variations from dbSNP and Humsavar for IRF5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs752637 -- 128,939,366(-) CTTTC(A/G)GCTTC upstream-variant-2KB, intron-variant
rs1318650 -- 128,942,542(+) ctgcc(A/T)cctgg intron-variant
rs1812183 -- 128,942,586(+) tagct(A/G)ggatt intron-variant
rs1874327 -- 128,945,322(-) tggag(A/T)ccagc intron-variant
rs1874328 -- 128,945,050(-) AGCTG(C/T)TGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for IRF5 Gene

Variant ID Type Subtype PubMed ID
esv2735137 CNV Deletion 23290073
esv2670312 CNV Deletion 23128226
nsv831125 CNV Loss 17160897
esv22837 CNV Gain 19812545
nsv889192 CNV Loss 21882294

Relevant External Links for IRF5 Gene

HapMap Linkage Disequilibrium report
IRF5
Human Gene Mutation Database (HGMD)
IRF5

Disorders for IRF5 Gene

(2) OMIM Diseases for IRF5 Gene (607218)

UniProtKB/Swiss-Prot

IRF5_HUMAN
  • Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:17881657}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269 PubMed:15657875}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17599733}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for IRF5 Gene

(5) Novoseek inferred disease relationships for IRF5 Gene

Disease -log(P) Hits PubMed IDs
lupus erythematosus systemic 73.5 23
rheumatoid arthritis 50.5 12
autoimmune diseases 48.7 5
virus infection 15.4 3
tumors 0 3

Relevant External Links for IRF5

Genetic Association Database (GAD)
IRF5
Human Genome Epidemiology (HuGE) Navigator
IRF5
genes like me logo Genes that share disorders with IRF5: view

Publications for IRF5 Gene

  1. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PMID: 15657875) Sigurdsson S. … Syvaenen A.-C. (Am. J. Hum. Genet. 2005) 3 4 23 49
  2. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. (PMID: 16642019) Graham R.R. … Alarcon-Riquelme M.E. (Nat. Genet. 2006) 3 4 23 49
  3. Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. (PMID: 17599733) Sigurdsson S. … Ronnblom L. (Arthritis Rheum. 2007) 3 4 23 49
  4. An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. (PMID: 17881657) Dideberg V. … Syvaenen A.-C. (Hum. Mol. Genet. 2007) 3 4 23 49
  5. Association of an IRF5 gene functional polymorphism with SjAPgren's syndrome. (PMID: 18050197) Miceli-Richard C. … Mariette X. (Arthritis Rheum. 2007) 3 23 49

Products for IRF5 Gene

Sources for IRF5 Gene

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