IRF5 Gene
protein-coding GIFtS: 63
GCID: GC07P128577
|
|
interferon regulatory factor 5
| |
Aliases
for IRF5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Interferon Regulatory Factor 51 2 | | IRF-52 3 | | SLEB102 5 | | IBD145 |
Export aliases for IRF5 gene to outside databasesPrevious GC identifers: GC07P127056 GC07P128118 GC07P128131 GC07P128171 GC07P128365 GC07P122939 |
Summaries
for IRF5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for IRF5:
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors withdiverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation,apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminalDNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms havebeen found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.(provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: IRF5_HUMAN, Q13568Function: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines uponvirus infection. Activated by TLR7 or TLR8 signaling
Gene Wiki entry for IRF5
|
Genomic Views
for IRF5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the IRF5 gene promoter:
p53 AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for IRF5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q32 Ensembl cytogenetic band: 7q32.1 HGNC cytogenetic band: 7q32IRF5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P128577: view genomic region
(about GC identifiers)
Start:
|
128,577,666 bp from pter |
End:
|
128,590,089 bp from pter |
Size:
|
12,424 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 127,961,737-127,973,832 |
|
Proteins
for IRF5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: IRF5_HUMAN, Q13568 (See
protein sequence)Recommended Name: Interferon regulatory factor 5 Size: 498 amino acids; 56044 Da
Subunit: Homodimer, when phosphorylated
Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm
1 PDB 3D structure from  and Proteopedia  for IRF5:3DSH (3D)
Secondary accessions: A4D1J8 A8DUA8 A8DUA9 E7EQ16 E7EW54 Q64GA9 Q64GB1 Q64GB2 Q6RCM8 Q9BQF0Alternative splicing: 5 isoforms: Q13568-1 Q13568-2 Q13568-3 Q13568-4 Q13568-5 Explore the universe of human proteins at neXtProt for IRF5: NX_Q13568
Post-translational modifications:
Phosphorylation of serine and threonine residues in a C-terminal autoinhibitory region, stimulates dimerization,transport into the nucleus, assembly with the coactivator CBP/p300 and initiation of transcription1
'Lys-63'-linked polyubiquitination by TRAF6 is required for activation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q13568
IRF5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001092097.2 NP_001092099.1 NP_001092100.1 NP_001229381.1 NP_116032.1
ENSEMBL proteins: ENSP00000418037 ENSP00000349770 ENSP00000419950 ENSP00000417770 ENSP00000419056 ENSP00000385352 ENSP00000420274 ENSP00000417454 ENSP00000419149 ENSP00000418534 ENSP00000249375 Reactome Protein details: Q13568
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
IRF5 for ontologies About GeneDecksing
IRF5 Antibody Products:
Assay Products for IRF5: |
Protein
Domains /
Families
for IRF5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
IRF5 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q13568ProtoNet protein and cluster: Q13568 1 Blocks protein family: IPB001346 Interferon regulatory factor
UniProtKB/Swiss-Prot: IRF5_HUMAN, Q13568Similarity: Belongs to the IRF familySimilarity: Contains 1 IRF tryptophan pentad repeat DNA-binding domain |
Function
for IRF5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: IRF5_HUMAN, Q13568Function: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines uponvirus infection. Activated by TLR7 or TLR8 signaling Genatlas biochemistry entry for IRF5:interferon regulatory factor 5,56kDa
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF5 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF5 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): IRF5 (NM_032643) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF5 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000975 | regulatory region DNA binding |
IEA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
IRF5 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Irf5tm1Ttg for IRF5
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Irf5):
IRF5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for IRF5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytokine Signaling in Immune system | | | 2 | Expression of IFN-induced genes | | | 3 | Interferon gamma signaling | | | 4 | Toll-like receptor signaling pathway | | | 5 | Lymphocyte Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for IRF5
4  BioSystems Pathways for IRF5
5/7 
Reactome Pathways for IRF5 (see all 7)
1 
Kegg Pathway (Kegg details for IRF5):
IRF5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for IRF5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/100 Interacting proteins for IRF5 (Q135681, 3 ENSP000003497704) via UniProtKB, MINT, STRING, and/or I2D (see all 100)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0009615 | response to virus |
-- | -- | | GO:0019221 | cytokine-mediated signaling pathway |
TAS | -- | | GO:0032494 | response to peptidoglycan |
IDA | -- | | GO:0032495 | response to muramyl dipeptide |
IDA | -- |
IRF5 for ontologies About GeneDecksing
|
Drugs & Compounds
for IRF5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
IRF5 for compounds About GeneDecksing
 Browse Tocris compounds for IRF5
2 Novoseek chemical compound relationships for IRF5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
1.4 |
3 |
15657875 (1), 20453440 (1), 19758313 (1) |
| vegf |
0 |
1 |
15492278 (1) |
Search CenterWatch for drugs/clinical trials and news about IRF5
|
Transcripts
for IRF5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for IRF5 gene (5 alternative transcripts): NM_001098627.2 NM_001098629.1 NM_001098630.1 NM_001242452.1 NM_032643.3 Unigene Cluster for IRF5: Interferon regulatory factor 5 Hs.521181 [show with all ESTs]Unigene Representative Sequence: NM_00109862913 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489702 ENST00000488569(uc011kot.1) ENST00000357234(uc010lls.1 uc010llw.1)
ENST00000477535 ENST00000479582 ENST00000464557 ENST00000461416(uc010llr.1 uc011kou.1 uc010llv.1)
ENST00000402030(uc003voh.3 uc003vog.3 uc010llt.3 uc003voj.4)
ENST00000473787 ENST00000467002 ENST00000473745(uc010llu.1 uc003vok.2)
ENST00000465603 ENST00000249375(uc003voi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF5 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF5 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): IRF5 (NM_032643) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for IRF5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF5 |
Additional cDNA sequence: AK293654.1 AK297083.1 AL713733.1 AY504946.1 AY504947.1 AY693665.1 AY693666.1 AY693667.1 AY693668.1 AY693669.1 BC004139.2 BC004201.2 DQ277633.1 DQ995491.1 EU258895.1 EU258896.1 EU258897.1 EU258898.1 U51127.1 13 DOTS entries: DT.413457 DT.92422943 DT.100742186 DT.121064067 DT.102840289 DT.121064069 DT.99931478 DT.95083057 DT.100023208 DT.121064074 DT.95181648 DT.121064061 DT.99948387 24/96 AceView cDNA sequences (see all 96): BC004201 AY504946 AW073783 NM_002200 AY504947 BF223643 BC004139 AL713733 CA774847 BU950357 NM_032643 AI341354 AY693665 AW438874 AI861864 AI769697 CA946780 BF939972 CR610038 CD672903 AI356449 AI985567 AY693666 AI086403
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for IRF5 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for IRF5
|
Expression
for IRF5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| IRF5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCCTGATTT
About this image
See IRF5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for IRF5
SOURCE GeneReport for Unigene cluster: Hs.521181
SABiosciences Expression via Pathway-Focused PCR Arrays including IRF5 (see all 7):
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat IRF5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF5 |
Orthologs
for IRF5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for IRF5 gene from 2/14 species (see all 14) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
IRF51 |
interferon regulatory factor 5 |
66.81(n)
61.81(a) |
|
430409 NM_001031587.1 NP_001026758.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
irf56 |
interferon regulatory factor 5 |
49(a) |
1 ↔ 1 |
4(12670131-12679345) |
ENSEMBL Gene Tree for IRF5 (if available)
TreeFam Gene Tree for IRF5 (if available) |
Paralogs
for IRF5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for IRF5 gene
- IRF82 IRF22 IRF32 IRF42 IRF92 IRF12 IRF62 IRF72
18/19 SIMAP similar genes for IRF5 using alignment to 14 protein entries: IRF5_HUMAN (see all proteins)
(see all similar genes):COQ5 MST132 PFKFB3 TUBA1C FLJ00047 KIAA0101
NELFA SUMO1 IRF6 IRF8 SEC14L3 IRF4
IRF2 IRF9 IRF1 HBP1 IRF3 AAMDC
IRF5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for IRF5
PGOHUM00000249745
|
Genomic Variants
for IRF5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for IRF5 (128577666 - 128590089 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for IRF5
2 CNVs: 70039 4559
Human Gene Mutation Database (HGMD): IRF5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF5 |
|
Disorders
/ Diseases
for IRF5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
IRF5 for disorders About GeneDecksing
OMIM gene information: 607218
OMIM disorders: 612245 612251
UniProtKB/Swiss-Prot: IRF5_HUMAN, Q13568
Genetic variations in IRF5 are associated with susceptibility to inflammatory bowel disease type 14 (IBD14)[MIM:612245]. IBD14 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It issubdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of thegastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowelinflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianalfistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosallayers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin,eyes, or joints Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10 (SLEB10)[MIM:612251]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorderof connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought torepresent a failure of the regulatory mechanisms of the autoimmune system Genetic variations in IRF5 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is asystemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects thejoints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespreadfibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bonystructures
20/33  diseases for IRF5 (see all 33): About MalaCardssystemic lupus erythematosus lupus erythematosus inflammatory bowel disease 14 dengue hemorrhagic fever
interleukin receptor hemorrhagic fever inflammatory bowel disease wegener's granulomatosis
systemic lupus erythematosus, association with primary biliary cirrhosis rheumatoid arthritis systemic scleroderma
lupus nephritis antiphospholipid syndrome ulcerative colitis kaposi's sarcoma
myocardial infarction nephritis bronchiolitis behcet's disease
2 diseases from the University of Copenhagen DISEASES database for IRF5:Systemic lupus erythematosus Systemic scleroderma 5 Novoseek disease relationships for IRF5 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lupus erythematosus systemic |
73.5 |
24 |
18843782 (2), 19043711 (2), 20112383 (2), 18063667 (2) (see all 19) |
| rheumatoid arthritis |
50.5 |
15 |
17133578 (2), 18408250 (2), 19228650 (2), 17599733 (2) (see all 8) |
| autoimmune diseases |
48.7 |
6 |
18050197 (1), 18063667 (1), 18408250 (1), 18824541 (1) (see all 5) |
| virus infection |
15.4 |
3 |
15308637 (2), 15556946 (1) |
| tumors |
0 |
3 |
18332133 (1), 15695821 (1), 20237317 (1) |
Genetic Association Database (GAD): IRF5
Human Genome Epidemiology (HuGE) Navigator: IRF5 (94 documents)
Export disorders for IRF5 gene to outside databases
|
Publications
for IRF5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for IRF5 gene, integrated from 9 sources (see all 156):
(articles sorted by number of sources associating them with IRF5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus. (PubMed id 15657875)1, 2, 4, 9 Sigurdsson S....Syvanen A.C. (2005)
- Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. (PubMed id 18824541)1, 2, 9 Balkhi M.Y....Pitha P.M. (2008)
- A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization. (PubMed id 15556946)1, 2, 9 Lin R....Hiscott J. (2005)
- The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling. (PubMed id 15695821)1, 2, 9 Schoenemeyer A.... Golenbock D.T. (2005)
- Two discrete promoters regulate the alternatively spliced human interferon regulatory factor-5 isoforms. Multiple isoforms with distinct cell type-specific expression, localization, regulation, and function. (PubMed id 15805103)1, 2, 9 Mancl M.E.... Barnes B.J. (2005)
- Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. (PubMed id 17599733)1, 2, 9 Sigurdsson S.... Ronnblom L. (2007)
- An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. (PubMed id 17881657)1, 2, 9 Dideberg V.... Syvaenen A.-C. (2007)
- A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus. (PubMed id 16642019)1, 2, 9 Graham R.R....Alarcon-Riquelme M.E. (2006)
- Activation of interferon regulatory factor 5 by site specific phosphorylation. (PubMed id 22412986)1, 2 Chang Foreman H.C.... Reich N.C. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for IRF5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing IRF5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing IRF5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing IRF5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for IRF5 gene:
Search GeneIP for patents involving IRF5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for IRF5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for IRF5 | | OriGene shRNA RFP for IRF5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for IRF5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for IRF5 | | | OriGene Protein Over-expression Lysate for IRF5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for IRF5 | | OriGene 3'-UTR Clone for IRF5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for IRF5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for IRF5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for IRF5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for IRF5 | | OriGene Custom Protein Services for IRF5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat IRF5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing IRF5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat IRF5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat IRF5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat IRF5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat IRF5 |
| |
 |  |  |  | |
| | Antibodies & Assays for IRF5 |
| | | | Search Tocris compounds for IRF5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | IRF5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for IRF5 |
|  |  |  | | | | ThermoFisher Antibodies for IRF5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat IRF5 |
|
|
|
|
