External Ids for IRF5 Gene
Previous GeneCards Identifiers for IRF5 Gene
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]
GeneCards Summary for IRF5 Gene
IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include diffuse cutaneous systemic sclerosis and inflammatory bowel disease 14. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and regulatory region DNA binding. An important paralog of this gene is IRF3.
UniProtKB/Swiss-Prot for IRF5 Gene
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling.